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https://www.readbyqxmd.com/read/29622992/the-degree-of-hair-graying-as-an-independent-risk-marker-for-coronary-artery-disease-a-ct-coronary-angiography-study
#1
Amr Abdel Aziz ElFaramawy, Irini Samuel Hanna, Reham Mohamed Darweesh, Ahmed Shehata Ismail, Hossam Ibrahim Kandil
Background: Cardiovascular disease is a leading cause of death worldwide. Aging is an unavoidable coronary risk factor and is associated with dermatological signs that could be a marker for increased coronary risk. We tested the hypothesis that hair graying as a visible marker of aging is associated with risk of coronary artery disease (CAD) independent of chronological age. Methods: This cross-sectional study included 545 males who underwent a computed tomography coronary angiography (CTCA) for suspicious of CAD, patients were divided into subgroups according to the percentage of gray/white hairs (Hair Whitening Score, HWS: 1-5) and to the absence or presence of CAD...
March 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29560293/a-myth-still-needs-to-be-clarified-a-case-report-of-the-frank-s-sign
#2
Aung Naing Lin, Kyawzaw Lin, Htoo Kyaw, Joseph Abboud
Despite advancements in diagnostic tools, physical signs such as xanthelasmata, arcus corneae, facial wrinkles, and gray hair are useful indicators of underlying diseases. The presence of bilateral diagonal earlobe creases (DELCs), also known as Frank's sign, correlates with a myriad of cardiovascular diseases such as coronary artery disease, cerebrovascular disease, and peripheral vascular disease. The use of Frank's sign as a bedside predictor of underlying coronary artery disease is controversial among clinicians...
January 17, 2018: Curēus
https://www.readbyqxmd.com/read/29488689/morphological-changes-of-hair-melanosomes-by-aging
#3
Takashi Itou
Various changes appear in hair by aging and graying is the most remarkable one. Changes in melanocytes have been well studied as the cause, however, little is known about the change of melanosomes which have a role of carrying melanin pigments into hair shafts. Using pigmented hairs of Japanese females from their age of 4 to 75, I isolated melanosomes and observed them. As a result, I found a significant change in the morphology of hair melanosomes with age. They were ellipsoidal on the whole and there was no age dependence in the major axis, while the minor axis significantly increased and its frequency distribution broadened with age...
February 28, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29442220/methylquercetins-stimulate-melanin-biosynthesis-in-a-three-dimensional-skin-model
#4
Kosei Yamauchi, Tohru Mitsunaga
In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF). In contrast, 3MQ increased the activity of melanogenic enzymes without the involvement of MITF, which suggests that 3MQ inhibits the degradation of melanogenic enzymes. In the present study, we investigated the effects of 3MQ and 34'7TMQ on melanogenesis in normal human melanocytes and using a commercial three-dimensional (3D) skin model system...
February 13, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29430877/detection-of-prohibited-substances-in-equine-hair-by-ultra-high-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry-application-to-doping-control-samples
#5
B Gray, M Viljanto, E Menzies, L Vanhaecke
The detection of drugs in human hair samples has been performed by laboratories around the world for many years and the matrix is popular in disciplines such as workplace drug testing. To date, however, hair has not become a routinely utilised matrix in sports drug detection. The analysis of hair samples offers a number of potential advantages to doping control laboratories, not least of which are the greatly extended detection window and the ease of sample collection and storage. This paper describes the development, validation and utilisation of a sensitive ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS) method for the detection of 50 compounds...
February 12, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29405374/separating-fast-and-slow-exchange-transfer-and-magnetization-transfer-using-off-resonance-variable-delay-multiple-pulse-vdmp-mri
#6
Lin Chen, Xiang Xu, Haifeng Zeng, Kannie W Y Chan, Nirbhay Yadav, Shuhui Cai, Kathryn J Schunke, Nauder Faraday, Peter C M van Zijl, Jiadi Xu
PURPOSE: To develop a method that can separate and quantify the fast (>1 kHz) and slow exchange transfer and magnetization transfer components in Z-spectra. METHODS: Z-spectra were recorded as a function of mixing time using a train of selective pulses providing variable-delay multipulse build-up curves. Fast and slow transfer components in the Z-spectra were separated and quantified on a voxel-by-voxel basis by fitting the mixing time-dependent CEST signal using a 3-pool model...
February 5, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29316174/protective-effect-of-conditioner-agents-on-hair-treated-with-oxidative-hair-dye
#7
Robson M da Gama, Simone A França-Stefoni, Tânia C Sá-Dias, Valcinir Bedin, André R Baby, Maria Valéria R Velasco
BACKGROUND: Hair coloring is broadly used by women and men either to change their natural hair color or to delay the onset of gray hair. Oxidative dyes may damage the hair, as chemical and physical processes are required to convert the fiber structure and, consequently, alterations in its mechanical and surface properties. OBJECTIVES: The aim of this study was to evaluate the protective effect of silanetriol (and) Panthenol, PEG-12 dimethicone, and hydrolyzed silk (and) hydrolyzed milk protein (and) lactose as conditioner agents on hair treated with oxidative hair dye by protein loss, combability, and breaking strength...
January 7, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29189417/brief-report-adherence-biomarker-measurements-in-older-and-younger-hiv-infected-adults-receiving-tenofovir-based-therapy
#8
Sharon M Seifert, Jose R Castillo-Mancilla, Kristine Erlandson, Mary Morrow, Monica Gandhi, Karen Kuncze, Howard Horng, Jia-Hua Zheng, Lane R Bushman, Jennifer J Kiser, Samantha MaWhinney, Peter L Anderson
BACKGROUND: Concentrations of tenofovir (TFV) in hair and tenofovir diphosphate (TFV-DP) in dried blood spots (DBSs) as measures of cumulative exposure have been primarily studied in younger, HIV-uninfected individuals taking preexposure HIV prophylaxis. Data on these measures among older HIV-infected individuals are limited. METHODS: We evaluated longitudinal TFV and TFV-DP concentrations in hair and DBS, respectively, from HIV-infected adults. Multivariable model variables included age group (18-35 and 60 years and older), creatinine clearance (CrCl), hematocrit (TFV-DP), and gray hair color (TFV)...
March 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29142740/combined-empirical-mode-decomposition-and-texture-features-for-skin-lesion-classification-using-quadratic-support-vector-machine
#9
Maram A Wahba, Amira S Ashour, Sameh A Napoleon, Mustafa M Abd Elnaby, Yanhui Guo
Purpose: Basal cell carcinoma is one of the most common malignant skin lesions. Automated lesion identification and classification using image processing techniques is highly required to reduce the diagnosis errors. Methods: In this study, a novel technique is applied to classify skin lesion images into two classes, namely the malignant Basal cell carcinoma and the benign nevus. A hybrid combination of bi-dimensional empirical mode decomposition and gray-level difference method features is proposed after hair removal...
December 2017: Health Information Science and Systems
https://www.readbyqxmd.com/read/29112905/determinants-of-hair-cortisol-concentration-in-children-a-systematic-review
#10
REVIEW
N A Gray, A Dhana, L Van Der Vyver, J Van Wyk, N P Khumalo, D J Stein
BACKGROUND: Several factors are known contribute to hair cortisol concentration (HCC) in adults. However, there is less research on determinants of HCC in children and adolescents. HCC is a valuable tool for medical research pertaining to the hypothalamic-pituitary-adrenal (HPA) axis. This review aims to assess the extent to which established determinants of HCC in adults have been consistently reported in children (birth - 18 years) and to identify determinants of HCC specific to this age group...
January 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29050206/wnt-%C3%AE-catenin-signaling-promotes-aging-associated-hair-graying-in-mice
#11
Zhihui Zhang, Mingxing Lei, Haoran Xin, Chunyan Hu, Tian Yang, Yizhan Xing, Yuhong Li, Haiying Guo, Xiaohua Lian, Fang Deng
Canities is an obvious sign of aging in mouse and human, shown as hair graying. Melanocytes in the hair follicle show cyclic activity with hair cycling, which transitions from anagen, catagen to telogen. How the hairs turn gray during aging is not completely uncovered. Here, by using immunostaining and LacZ staining in Dct-LacZ mice, we show that β-catenin is expressed in melanocytes during hair cycling. RT-PCR, western blot and immunostaining show that β-catenin expression is significantly increased in both anagen and telogen skin of aged mice, when compared to the anagen and telogen skin of young mice, respectively...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29019940/effects-of-extremely-low-frequency-electromagnetic-fields-on-melanogenesis-through-p-erk-and-p-sapk-jnk-pathways-in-human-melanocytes
#12
Yu-Mi Kim, Sang-Eun Cho, Soo-Chan Kim, Hyun-Joon Jang, Young-Kwon Seo
This study evaluated frequency-dependent effects of extremely low frequency electromagnetic fields (ELF-EMFs) on melanogenesis by melanocytes in vitro. Melanocytes were exposed to 2 mT EMFs at 30-75 Hz for 3 days before melanogenesis was examined. Exposure to ELF-EMFs at 50 and 60 Hz induced melanogenic maturation without cell damage, without changing cell proliferation and mitochondrial activity. Melanin content and tyrosinase activity of cells exposed to 50 Hz were higher than in controls, and mRNA expression of tyrosinase-related protein-2 was elevated relative to controls at 50 Hz...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28973148/a-constitutive-bcl2-down-regulation-aggravates-the-phenotype-of-pkd1-mutant-induced-polycystic-kidney-disease
#13
Laurence Duplomb, Nathalie Droin, Olivier Bouchot, Christel Thauvin-Robinet, Ange-Line Bruel, Julien Thevenon, Patrick Callier, Guillaume Meurice, Noémie Pata-Merci, Romaric Loffroy, David Vandroux, Romain D A Costa, Virginie Carmignac, Eric Solary, Laurence Faivre
The main identified function of BCL2 protein is to prevent cell death by apoptosis. Mouse knock-out for Bcl2 demonstrates growth retardation, severe polycystic kidney disease (PKD), grey hair and lymphopenia, and die prematurely after birth. Here, we report a 40-year-old male referred to for abdominal and thoracic aortic dissection with associated aortic root aneurysm, PKD, lymphocytopenia with a history of T cell lymphoblastic lymphoma, white hair since the age of 20, and learning difficulties. PKD, which was also detected in the father and sister, was related to an inherited PKD1 mutation...
December 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28928092/idh2-deficiency-accelerates-renal-dysfunction-in-aged-mice
#14
Su Jeong Lee, Hanvit Cha, Seoyoon Lee, Hyunjin Kim, Hyeong Jun Ku, Sung Hwan Kim, Jung Hyun Park, Jin Hyup Lee, Kwon Moo Park, Jeen-Woo Park
The free radical or oxidative stress theory of aging postulates that senescence is due to an accumulation of cellular oxidative damage, caused largely by reactive oxygen species (ROS) that are produced as by-products of normal metabolic processes in mitochondria. The oxidative stress may arise as a result of either increased ROS production or decreased ability to detoxify ROS. The availability of the mitochondrial NADPH pool is critical for the maintenance of the mitochondrial antioxidant system. The major enzyme responsible for generating mitochondrial NADPH is mitochondrial NADP+ -dependent isocitrate dehydrogenase (IDH2)...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28884913/a-girl-with-gray-hair-and-pyogenic-infections
#15
Sara Palencia-Pérez, Fátima Tous-Romero, Ana María Delgado-Márquez
No abstract text is available yet for this article.
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28761265/light-microscopy-and-polarized-microscopy-a-dermatological-tool-to-diagnose-gray-hair-syndromes
#16
P L Chandravathi, Hetal Deepak Karani, Sirisha Rani Siddaiahgari, Lokesh Lingappa
Gray hair syndromes are rare syndromes which have an autosomal recessive inheritance and are characterized by pigmentary dilution of skin and hair, defects in immunological function, and nervous system defects. They comprise three disorders namely Chediak-Higashi syndrome (CHS), Griscelli syndrome (GPS), and Elejalde syndrome. Clinically, it is difficult to distinguish these disorders as their clinical features may overlap. Hence, to make a correct diagnosis and differentiate between CHS and GPS light microscopic examination of skin and hair shafts as well as peripheral blood smear evaluations should be done...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28649248/a-combination-of-podophyllotoxin-and-rutin-alleviates-radiation-induced-pneumonitis-and-fibrosis-through-modulation-of-lung-inflammation-in-mice
#17
Savita Verma, Bhargab Kalita, Sania Bajaj, Hridayesh Prakash, Ajay Kumar Singh, Manju Lata Gupta
Pneumonitis and pulmonary fibrosis are predominant consequences of radiation exposure, whether planned or accidental. The present study, demonstrates radioprotective potential of a formulation, prepared by combining podophyllotoxin and rutin (G-003M), in mice exposed to 11 Gy thoracic gamma radiation (TGR). Treated mice were observed for survival and other symptomatic features. Formation of reactive oxygen species (ROS)/nitric oxide (NO) was measured in bronchoalveolar lavage cells. DNA damage and cell death were assessed in alveolar cells by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28649126/cis-stilbene-glucoside-in-polygonum-multiflorum-induces-immunological-idiosyncratic-hepatotoxicity-in-lps-treated-rats-by-suppressing-ppar-%C3%AE
#18
Ya-Kun Meng, Chun-Yu Li, Rui-Yu Li, Lan-Zhi He, He-Rong Cui, Ping Yin, Cong-En Zhang, Peng-Yan Li, Xiu-Xiu Sang, Ya Wang, Ming Niu, Ya-Ming Zhang, Yu-Ming Guo, Rong Sun, Jia-Bo Wang, Zhao-Fang Bai, Xiao-He Xiao
The root of Polygonum multiflorum Thunb (PM) has been used in China to treat a variety of diseases, such as constipation, early graying of the hair and hyperlipemia. Recent evidence shows that PM causes idiosyncratic drug-induced liver injury (IDILI) in humans. In this study, we investigated the molecular basis of PM-induced liver injury in a rat model of IDILI based on a non-hepatotoxic dose of LPS. SD rats were orally administered 3 potentially hepatotoxic compounds of PM: cis-stilbene glucoside (cis-SG, 50 mg/kg), trans-SG (50 mg/kg) or emodin (5 mg/kg), followed by injection of LPS (2...
October 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28598005/higher-concentrations-of-dithranol-appear-to-induce-hair-growth-even-in-severe-alopecia-areata
#19
M R Ngwanya, N A Gray, F Gumedze, A Ndyenga, N P Khumalo
Alopecia areata (AA) is the commonest autoimmune cause of non-scarring alopecia. Topical treatments including corticosteroids and irritants maybe beneficial. Studies report variable hair regrowth with dithranol (anthralin) but all used low concentrations (0.1-1.25%) and inconsistent measurements of AA severity. We report retrospective data (2005-2014) of 102 patients who had failed ultra-potent topical steroids and were referred to a specialist hair clinic for treatment with dithranol up to 3%. The severity of alopecia areata tool was used and participants graded as mild (<25%), moderate (>25 to 75%), and severe (>75%) hair loss...
July 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28593683/aging-in-hair-follicle-stem-cells-and-niche-microenvironment
#20
REVIEW
Jiang Ji, Bryan Siu-Yin Ho, Ge Qian, Xiao-Ming Xie, Paul Lorenz Bigliardi, Mei Bigliardi-Qi
Hair graying and hair loss are prominent and common characteristics of the elderly population. In some individuals these processes can significantly impact their quality of life, leading to depression, anxiety and other serious mental health problems. Accordingly, there has been much interest in understanding the complex physiological changes within the hair follicle in the aging individual. It is now known that hair follicles represent a prototypical stem cell niche, where both micro- and macroenvironmental influences are integrated alongside stem cell-stem cell and stem cell-stem niche interactions to determine hair growth or hair follicle senescence...
June 8, 2017: Journal of Dermatology
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