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https://www.readbyqxmd.com/read/29678595/trimodalities-for-bladder-cancer-in-elderly-transurethral-resection-hypofractionated-radiotherapy-and-gemcitabine
#1
H A H Mohamed, M A Salem, M S Elnaggar, A Gabr, A M Abdelrheem
PURPOSE: A prospective phase II study carried out to evaluate hypofractionated radiotherapy with concurrent gemcitabine for bladder preservation in the elderly patient with bladder cancer. PATIENTS AND METHODS: Thirty-one patients were enrolled, age ≥65years, diagnosed with transitional cell carcinoma of the urinary bladder, after a maximum safe transurethral resection of a bladder tumour. They received 52.5Gy in 20 fractions using 3D conformal radiotherapy with concurrent 100mg/m2 gemcitabine weekly as a radiosensitizer...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#2
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29660813/impact-of-psychiatric-illness-on-decreased-survival-in-elderly-patients-with-bladder-cancer-in-the-united-states
#3
Usama Jazzar, Shan Yong, Zachary Klaassen, Jinhai Huo, Byron D Hughes, Edgar Esparza, Hemalkumar B Mehta, Simon P Kim, Douglas S Tyler, Stephen J Freedland, Ashish M Kamat, Dwight V Wolf, Stephen B Williams
BACKGROUND: Treatments for muscle-invasive bladder cancer are multimodal, complex, and often carry significant risks of physical and psychological morbidity. The objectives of this study were to define the incidence and types of psychiatric illnesses diagnosed after treatment and to determine their impact on survival outcomes. METHODS: In total, 3709 patients who were diagnosed with clinical stage T2 through T4a bladder cancer from January 1, 2002, to December 31, 2011, from the Surveillance, Epidemiology, and End Results-Medicare were analyzed...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29648580/bevacizumab-plus-hypofractionated-radiotherapy-versus-radiotherapy-alone-in-elderly-patients-with-glioblastoma-the-randomized-open-label-phase-ii-arte-trial
#4
H-G Wirsching, G Tabatabai, U Roelcke, A F Hottinger, F Jörger, A Schmid, L Plasswilm, D Schrimpf, C Mancao, D Capper, K Conen, T Hundsberger, F Caparrotti, R von Moos, C Riklin, J Felsberg, P Roth, D T W Jones, S Pfister, E J Rushing, L Abrey, G Reifenberger, L Held, A von Deimling, A Ochsenbein, M Weller
Background: The addition of bevacizumab to temozolomide-based chemoradiotherapy (TMZ/RT→TMZ) did not prolong overall survival (OS) in patients with newly diagnosed glioblastoma in phase III trials. Elderly and frail patients are underrepresented in clinical trials, but early reports suggested preferential benefit in this population. Patients and Methods: ARTE was a 2:1 randomized, multi-center, open-label, non-comparative phase II trial of hypofractionated RT (40 Gy in 15 fractions) with bevacizumab (10 mg/kg x 14 days) (arm A, N = 50) or without bevacizumab (arm B, N = 25) in patients with newly diagnosed glioblastoma aged ≥65 years...
April 10, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29619003/the-clinical-significance-of-o-6-methylguanine-dna-methyltransferase-promoter-methylation-status-in-adult-patients-with-glioblastoma-a-meta-analysis
#5
Yu-Hang Zhao, Ze-Fen Wang, Chang-Jun Cao, Hong Weng, Cheng-Shi Xu, Kai Li, Jie-Li Li, Jing Lan, Xian-Tao Zeng, Zhi-Qiang Li
Background and objective: Promoter status of O6 -methylguanine-DNA methyltransferase ( MGMT ) has been widely established as a clinically relevant factor in glioblastoma (GBM) patients. However, in addition to varied therapy schedule, the prognosis of GBM patients is also affected by variations of age, race, primary or recurrent tumor. This study comprehensively investigated the association between MGMT promoter status and prognosis in overall GBM patients and in different GBM subtype including new diagnosed patients, recurrent patients and elderly patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29608256/aging-related-prognosis-analysis-of-definitive-radiotherapy-for-very-elderly-esophageal-cancer
#6
Yong-Chun Zhou, Li-Li Chen, Hong-Bo Xu, Qian Sun, Qi Zhang, Han-Fei Cai, Hao Jiang
Because of the exclusion for the patients more than 75 years (very elderly patients) in many clinical trials of esophageal cancer (EC), there is no consensus on prognosis and treatment for this population. We aim to evaluate the outcomes and aging-related prognostic factors of definitive radiotherapy (RT) for very elderly EC patients. We retrospectively analyzed 149 very elderly EC patients consecutively treated between January 2015 and June 2016 by definitive intensity-modulated radiotherapy (IMRT) with or without chemotherapy...
April 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29605057/first-nations-people-s-perspectives-on-barriers-and-supports-for-enhancing-hpv-vaccination-foundations-for-sustainable-community-driven-strategies
#7
R I Henderson, M Shea-Budgell, C Healy, A Letendre, L Bill, B Healy, R A Bednarczyk, K Mrklas, C Barnabe, J Guichon, N Bedingfield, S MacDonald, A Colquhoun, S Glaze, T Nash, C Bell, J Kellner, R Richardson, T Dixon, J Starlight, G Runner, G Nelson
OBJECTIVE: In Canada, Indigenous people have higher human papillomavirus (HPV) infection rates, lower screening rates for cervical cancer, and higher rates of invasive cancer, leading to worse cervical cancer-related outcomes than observed in non-Indigenous Canadian women. Lingering harms from European colonization drive these health inequities and create public health challenges. Policy guidance is needed to optimize HPV vaccination rates and, thereby, decrease the burden of HPV-related illness, including high-morbidity surgical procedures and chemo-radiotherapy...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29594874/oligometastatic-cancer-in-elderly-patients-the-blitzkrieg-radiotherapy-approach-sbrt-in-oligometastatic-elderly-patients
#8
Andrea Lancia, Gianluca Ingrosso, Alessandra Carosi, Marta Bottero, Alessandro Cancelli, Irene Turturici, Elisabetta Ponti, Riccardo Santoni
AIMS: To retrospectively evaluate the outcome of stereotactic body radiation therapy (SBRT) in the treatment of elderly patients affected by isolated body metastasis from different primitive tumors. METHODS: 70 patients with isolated body metastasis were treated. Median age at diagnosis was 75 years (IQR 69-80). The most common SBRT fractionation scheme was 5 × 7 Gy (total dose 35 Gy). The primary endpoints were Local Control (LC) and Toxicity. Secondary endpoints were Overall Survival (OS) and Disease-Specific Survival (DSS)...
March 29, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29588624/stereotactic-body-radiation-therapy-sbrt-in-the-management-of-non-small-cell-lung-cancer-clinical-impact-and-patient-perspectives
#9
REVIEW
Elysia K Donovan, Anand Swaminath
Stereotactic body radiation therapy (SBRT) has emerged as a new technology in radiotherapy delivery, allowing for potentially curative treatment in many patients previously felt not to be candidates for radical surgical resection of stage I non-small-cell lung cancer (NSCLC). Several studies have demonstrated very high local control rates using SBRT, and more recent data have suggested overall survival may approach that of surgery in operable patients. However, SBRT is not without unique toxicities, and the balance of toxicity, and effect on patient-reported quality of life need to be considered with respect to oncologic outcomes...
2018: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29581964/age-is-not-a-limiting-factor-in-interventional-radiotherapy-brachytherapy-for-patients-with-localized-cancer
#10
REVIEW
Valentina Lancellotta, György Kovács, Luca Tagliaferri, Elisabetta Perrucci, Giuseppe Colloca, Vincenzo Valentini, Cynthia Aristei
This review examines the role of interventional radiotherapy (IRT otherwise known as brachytherapy) in cancer treatment for elderly patients. Despite their advanced age and associated comorbidities, elderly patients should receive definitive cancer therapies, including surgery and radiotherapy (RT). In fact, RT becomes first-line option for patients who are not eligible for surgery (due to comorbidities, anticoagulant drugs, and risk of disfigurement) or those who refuse it. It emerged from this review of the literature as effective, simple, safe, and comfortable and was associated with good local control, low toxicity rates, and excellent cosmesis and provided a cost benefit...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29575839/-clinicopathological-features-of-second-primary-lung-cancer-and-pulmonary-metastasisin-patients-with-breast-cancer
#11
K W He, W Wei, Z Y Liu, X Song, P Y Zhuo, Q H Ma, Z Y Yu
Objective: To compare the clinicopathological characteristics of second primary lung cancer following breast cancer and lung metastases from breast cancer, and then to analyze the risk factors in breast cancer patients with second primary lung tumor. Methods: Clinical data of 55 breast cancer patients with second primary lung tumor and 205 breast cancer patients with solitary pulmonary metastasis in Shandong Cancer Hospital from January 2006 to January 2017 were retrospectively analyzed. The risk factors of primary lung cancer following breast cancer were analyzed using logistic regression model...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29572782/a-phase-i-ii-trial-of-pemetrexed-plus-radiotherapy-in-elderly-patients-with-locally-advanced-non-small-cell-lung-cancer
#12
Akihiro Tamiya, Masahiro Morimoto, Shoichi Fukuda, Yoko Naoki, Tatsuya Ibe, Kyoichi Okishio, Hideto Goto, Akihiro Yoshii, Toshiyuki Kita, Naoyuki Nogami, Yuka Fujita, Shinji Atagi
Background Radiotherapy (RT) is an effective treatment for elderly patients with locally advanced non-small-cell lung cancer (NSCLC); however, no clinical trials have investigated combination RT with pemetrexed (PEM) in chemotherapy-naive patients ≥71 years old. We conducted a phase I/II study to evaluate the appropriate PEM dose, efficacy, and safety of PEM plus RT in elderly patients. Methods Patients ≥71 years with performance status (PS) scores of 0-2 who had pathologically confirmed stage IIIA/IIIB NSCLC received PEM (500 mg/m2 on day 1 of a 28-day cycle, 4 courses) and RT (a single 2 Gy daily fraction on 5 consecutive days weekly from day 1; 60 Gy total)...
March 23, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29566922/nonsurgical-treatment-of-nonmelanoma-skin-cancer-in-the-mature-patient
#13
Romana Čeović, Mikela Petković, Zrinka Bukvić Mokos, Krešimir Kostović
Nonmelanoma skin cancer (NMSC) is the most common cancer, with the median age at NMSC diagnosis is 71 years. Treatment options for NMSC include surgical therapy, which is usually the first-choice treatment, and nonsurgical modalities. Therapeutic modalities depend on tumor localization, histologic type, and biologic behavior, as well as patient comorbidities, age, and life expectancy. Nonsurgical treatments include cryotherapy, local therapies (imiquimod, 5-fluorouracil, ingenol mebutate, and diclofenac), photodynamic therapy, radiotherapy, and hedgehog inhibitors...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29552309/thymoma-size-significantly-affects-the-survival-metastasis-and-effectiveness-of-adjuvant-therapies-a-population-based-study
#14
Dongliang Bian, Feng Zhou, Weiguang Yang, Kaixuan Zhang, Linsong Chen, Gening Jiang, Peng Zhang, Chunyan Wu, Ke Fei, Lei Zhang
Background: Thymoma, though a rare tumor disease, is the most common tumor of the anterior mediastinum. However, tumor size, as a critical factor, has been underestimated. Results: Age, advanced tumor stage, and preoperative radiotherapy were poor prognostic factors of overall survival (OS) and disease specific survival (DSS) ( P < 0.05 for all). Besides, tumor size was significantly related to survival. The larger tumor size indicated the less OS and DSS ( P < 0...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29545961/primary-peritoneal-angiosarcoma-metastatic-to-liver-and-bone-without-history-of-radiation-therapy
#15
Way Chiang, Zofia Tynski
Angiosarcoma is a rare vascular soft tissue tumor of endothelial origin most commonly seen in the elderly as a primary cutaneous head and neck malignancy. Furthermore, a peritoneal angiosarcoma is an exceedingly rare entity. This is the second case of primary peritoneal angiosarcoma reported in literature that is not associated with prior radiotherapy. Herein, we describe a case of primary peritoneal angiosarcoma metastatic to both the liver and bone in a male patient with metachronous renal cell carcinoma and parathyroid adenoma...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29530585/omission-of-adjuvant-radiotherapy-in-the-elderly-breast-cancer-patient-missed-opportunity
#16
Alex C Herskovic, Xian Wu, Paul J Christos, Himanshu Nagar
PURPOSE: We used the National Cancer Data Base to analyze practice patterns of adjuvant breast radiotherapy (RT) in elderly patients to see if a difference in overall survival (OS) could be detected. Additionally, we investigated factors that affected OS in these patients. PATIENTS AND METHODS: Women aged ≥ 65 years with hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative pathologic T1-T2N0M0 invasive breast cancer measuring up to 3 cm who were treated with breast conservation and adjuvant endocrine therapy without adjuvant chemotherapy were identified and stratified by use of adjuvant RT...
February 20, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29524319/efficacy-of-hypofractionated-radiotherapy-in-patients-with-non-melanoma-skin-cancer-results-of-a-systematic-review
#17
REVIEW
Dakshika A Gunaratne, Michael J Veness
Radiation oncologists are increasingly tasked with the management of elderly patients with non-melanoma skin cancer, unsuitable for surgical intervention due to inoperable lesions and/or poor performance status. In this cohort, hypofractionated radiotherapy, delivered either daily, alternative daily or once weekly is highly effective. A systematic literature search was conducted of PUBMED, MEDLINE and EMBASE databases using the algorithm ('radiotherapy' OR 'radiation therapy' OR 'brachytherapy') AND ('hypofraction' OR 'hypofractionated' OR 'hypofractionation') AND ('skin neoplasms' OR 'carcinoma' OR 'malignancy') AND ('skin' OR 'epidermis' OR 'epidermal' OR 'cutaneous')...
March 9, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29505670/clinical-and-economic-burden-associated-with-stage-iii-to-iv-triple-negative-breast-cancer-a-seer-medicare-historical-cohort-study-in-elderly-women-in-the-united-states
#18
Kendra L Schwartz, Michael S Simon, Lauren C Bylsma, Julie J Ruterbusch, Jennifer L Beebe-Dimmer, Neil M Schultz, Scott C Flanders, Arie Barlev, Jon P Fryzek, Ruben G W Quek
BACKGROUND: The current study was performed to describe patient characteristics, treatment patterns, survival, health care resource use (HRU), and costs among older women in the United States with advanced (American Joint Committee on Cancer stage III/IV) triple-negative breast cancer (TNBC) in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. METHODS: Women who were aged ≥66 years at the time of diagnosis and diagnosed with advanced TNBC between January 1, 2007, and January 1, 2011, in the SEER-Medicare database and who were followed for survival through December 31, 2013, were eligible...
March 5, 2018: Cancer
https://www.readbyqxmd.com/read/29494653/prevalence-and-risk-of-skeletal-complications-and-use-of-radiation-therapy-in-elderly-women-diagnosed-with-metastatic-breast-cancer
#19
Arif Hussain, Candice Yong, Katherine H R Tkaczuk, Yi Qian, Jorge Arellano, C Daniel Mullins, Eberechukwu Onukwugha
OBJECTIVE: Real-world data regarding patient factors associated with the occurrence of spinal cord compression (SCC) or pathological fracture (PF), or need for bone surgery (BS), or use of radiation therapy (RAD) (i.e. skeletal complications and radiation therapy; SCRT) are limited for women with metastatic breast cancer (BCa). Given the substantial clinical and economic burden of these events in advanced BCa, we conducted the present study to understand the prevalence and identify the risk factors associated with these events among elderly women presenting with de novo metastatic BCa...
2018: PloS One
https://www.readbyqxmd.com/read/29485367/orbital-malignant-meningioma-a-unique-presentation-of-a-rare-entity
#20
Dane H Slentz, Sunil Bellur, M Reza Taheri, M Isabel Almira-Suarez, Jonathan H Sherman, Tamer N Mansour
An elderly female with progressive proptosis was found to have an aggressive retrobulbar solid orbital mass. The mass was distinct from the optic nerve sheath and intracranial meninges, and produced concave erosion of the sphenoid wing. Operative findings demonstrated an orbital mass adherent to the dura of the superior orbital fissure. The mass did not demonstrate meningeal violation, infiltrate the superior orbital fissure, or display intracranial spread. The dura remained intact after gross total resection...
February 27, 2018: Orbit
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