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https://www.readbyqxmd.com/read/28216387/corrigendum-to-long-term-results-of-a-concomitant-boost-radiotherapy-technique-for-elderly-patients-with-muscle-%C3%A4-nvasive-bladder-cancer-j-geriatr-oncol6-4-july-2015-316-323
#1
Emine Canyilmaz, Adnan Yoney, Lasif Serdar, Gonca Hanedan Uslu, Ozlem Aynaci, Emel Haciislamoglu, Melek Nur Yavuz
No abstract text is available yet for this article.
February 16, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28205042/screening-relevant-age-threshold-of-70%C3%A2-years-and-older-is-a-stronger-determinant-for-the-choice-of-adjuvant-treatment-in-breast-cancer-patients-than-tumor-biology
#2
E C Inwald, O Ortmann, M Koller, F Zeman, F Hofstädter, M Evert, G Brockhoff, M Klinkhammer-Schalke
PURPOSE: The 70-year threshold determines whether patients are eligible or not for the breast cancer screening program in Germany. It is not known whether this age threshold also influences the choice of adjuvant treatment and ultimate outcome. METHODS: 3463 patients were analyzed from the clinical cancer registry Regensburg (Germany) with primary, non-metastatic invasive breast cancer diagnosed between 2000 and 2012. The distribution of tumor biological subtypes was evaluated in breast cancer patients both in those eligible for screening (ESG, 50-69 years) and those not eligible for screening (NESG, ≥70 years)...
February 15, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28191295/small-cell-carcinoma-of-the-prostate-in-an-elderly-patient-a-case-report-and-review-of-the-literature
#3
Dale Alan Whitaker, Daniel H Miller, Niveditha Jagadesh, Gerald W Strong, Lauren Hintenlang, William B Schenk, Gregory A Broderick, Katherine S Tzou, Steven J Buskirk
Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. To date our current knowledge base is largely limited to case reports and retrospective case reviews. The mainstay of treatment for this particular histology most often involves a multimodality approach utilizing chemotherapy in conjunction with radiation therapy, androgen deprivation therapy, or prostatectomy...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/28179337/mono-and-bi-weekly-hypofractionated-radiation-therapy-for-the-treatment-of-epithelial-skin-cancer-in-very-elderly-patients
#4
Maurizio Valeriani, Luca Nicosia, Linda Agolli, Chiara Reverberi, Emanuela Galvagno, Vitaliana DE Sanctis, Giuseppe Minniti, Marta Carlesimo, Mattia F Osti
BACKGROUND/AIM: Epithelial skin cancer frequently occurs in the elderly population, sometimes in an advanced stage, when intensive treatments are needed. Radiotherapy can achieve high response rates. We evaluated efficacy and tolerability of hypofractionated radiotherapy in a population of very elderly patients with locally advanced epithelial skin cancer. PATIENTS AND METHODS: Two different hypofractionated schedules were administered (21 patients): 6 Gy in 10 bi-weekly fractions (13 lesions) and 5 Gy in 12 bi-weekly fractions (13 lesions)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178025/the-short-term-impact-of-colorectal-cancer-treatment-on-physical-activity-functional-status-and-quality-of-life-a-systematic-review
#5
C J Cabilan, Sonia Hines
BACKGROUND: Physical activity, functional status and quality of life (QoL) are important determinants of the quality of life (QoL) after colorectal cancer (CRC) treatment; however, little is known on how the treatment impacts these outcomes. Having this understanding could help clinicians develop and implement strategies that would enhance or maintain the QoL of CRC patients. OBJECTIVES: To identify the impact of curative CRC treatment (surgery with or without radiotherapy and/or chemotherapy) on physical activity, functional status and QoL within one year of treatment or diagnosis...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28170130/cyclical-hypofractionated-radiotherapy-also-known-as-quad-shot-alone-using-intensity-modulated-radiotherapy-for-squamous-cell-carcinoma-of-the-parotid-gland-in-an-85-year-old-patient-with-multiple-comorbidities
#6
Whoon Jong Kil, Kevin Camphausen
BACKGROUND: Palliative radiotherapy (RT) is not commonly offered to patients with head and neck cancer because of the belief that toxicity from the RT would not provide great palliative benefits. The purpose of this study was for us to report the advantages of cyclical hypofractionated RT (QUAD Shot) using intensity-modulated RT (IMRT) for an elderly comorbid patient with head and neck cancer. METHODS: An 85-year-old multiple comorbid man with squamous cell carcinoma in the left parotid gland with left facial pain received the IMRT-QUAD Shot (14 Gy/4 fractions, twice-daily treatment with 6 hours interval, on 2 consecutive days) to lesions, which were repeated every 4 weeks 3 times...
February 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28169196/patterns-of-care-of-cervical-cancer-in-the-elderly-a-qualitative-literature-review
#7
Venkatesulu Bhanu Prasad, Supriya Mallick, G K Rath
INTRODUCTION: Cancer of the uterine cervix is the fourth most common cancer worldwide among women. However, there is limited data about elderly cervical cancer patients and gross underrepresentation of elderly patients in clinical trials. Hence, the optimal therapy of such patients is not well formulated. METHODOLOGY: We conducted this systematic review of evidence to assess patterns of care in elderly patients with cervical cancer. RESULTS: A total of 17,338 publications are reported in PubMed until July, 2016 pertaining to cervical cancer...
February 3, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28168322/radical-hypo-fractionated-radiotherapy-with-volumetric-modulated-arc-therapy-in-lung-cancer-a-retrospective-study-of-elderly-patients-with-stage%C3%A2-iii-disease
#8
D Franceschini, F De Rose, L Cozzi, P Navarria, E Clerici, C Franzese, T Comito, A Tozzi, C Iftode, G D'Agostino, M Sorsetti
BACKGROUND: This study aimed to analyse the feasibility and acute toxicity of radical hypo-fractionated radiotherapy (RT) for elderly patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: We conducted a retrospective evaluation of treatment with volumetric modulated arc therapy (VMAT) of elderly patients affected by stage III inoperable NSCLC. The dose prescription was 56 Gy in 20 fractions, 55 Gy in 22 fractions, or 50 Gy in 20 fractions...
February 6, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28161553/lower-incidence-of-esophagitis-in-the-elderly-undergoing-definitive-radiation-therapy-for-lung-cancer
#9
Payal D Soni, Philip S Boonstra, Matthew J Schipper, Latifa Bazzi, Robert T Dess, Martha M Matuszak, Feng-Ming Kong, James A Hayman, Randall K Ten Haken, Theodore S Lawrence, Gregory P Kalemkerian, Shruti Jolly
INTRODUCTION: Most patients with lung cancer are elderly and poorly represented in randomized clinical trials. They are often undertreated because of concerns about their ability to tolerate aggressive treatment. We tested the hypothesis that elderly patients undergoing definitive lung radiation might tolerate treatment differently than younger patients. METHODS: A total of 125 patients who underwent definitive lung radiotherapy were identified from a prospective institutional database (University of Michigan cohort)...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28138221/immunotherapy-for-the-treatment-of-colorectal-tumors-focus-on-approved-and-in-clinical-trial-monoclonal-antibodies
#10
REVIEW
Alex Françoso, Patricia Ucelli Simioni
Colorectal cancer is considered a disease of the elderly population. Since the number of geriatric patients continues to rise, monoclonal antibody therapy is the most promising therapy in the recent research. Presently, the monoclonal antibodies most frequently used in the treatment of colorectal tumors are bevacizumab, cetuximab, panitumumab, and ramucirumab. Bevacizumab is a monoclonal antibody that acts on VEGF. Cetuximab and panitumumab act on EGFR. Ramucirumab binds directly to the ligand-binding pocket of VEGFR-2 to block the binding of VEGF-A, VEGF-C, and VEGF-D...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28133817/postoperative-mortality-following-multi-modality-therapy-for-pancreatic-cancer-analysis-of-the-seer-medicare-data
#11
Preethy Nayar, Aastha Chandak, Niodita Gupta, Fang Yu, Fang Qiu, Apar Kishor Ganti, Chandrakanth Are
BACKGROUND AND OBJECTIVES: The objective of this study was to examine post-operative mortality for elderly pancreatic cancer patients treated with multi-modality therapy. METHODS: Surveillance Epidemiology and End Results (SEER) Medicare linked data were used to examine differences in mortality between patients who underwent pancreatectomy alone and those who had early (within 12 weeks) and late (after 12 weeks) adjuvant therapy (chemotherapy and/or radiotherapy)...
February 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28133288/-a-case-of-pure-squamous-cell-carcinoma-of-the-breast-in-an-elderly-woman-diagnosed-by-cytology
#12
Yasufumi Sato, Junichi Inatome, Masatsugu Okishiro, Yasuo Oneda, Tomo Ishida, Yoshihiro Morimoto, Ryuichi Kuwahara, Hiroki Kusama, Atsushi Naito, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Atsushi Takeno, Chiyomi Egawa, Yutaka Takeda, Takeshi Kato, Shigeyuki Tamura, Yuichi Takatsuka, Takayoshi Goto, Teruaki Nagano, Shinichi Nakatsuka
A n 85-year-old woman presented with a mass in the left breast. A3 7mm lobulated mass including enhancement of a cyst of 37mm was detected by sonography. An axillary lymph node had increased to 16 mm. Atypical cells dyed by light green and orange G were identified by fine needle aspiration and cytology. She was diagnosed with left breast cancer(cT2N1M0, Stage II B), histologically suspected to be squamous cell carcinoma. She underwent a left-breast-conserving surgery and axillary lymph node dissection. On pathology, a cyst of 34×30mm was noted...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132575/dermatologic-radiotherapy-in-the-treatment-of-extensive-basal-cell-carcinomas-a-retrospective-study
#13
R Piccinno, S Benardon, F M Gaiani, M Rozza, M Caccialanza
BACKGROUND: The increase of the number of new cases for year of basal cell carcinoma (BCC) has brought also an increase of BCC difficult to treat (extensive, locally advanced and high risk forms). OBJECTIVE: To evaluate retrospectively the results obtained with dermatologic radiotherapy (RT) for better defining the indications respect to new emerging treatments. METHODS: A series of extensive 115 BCC treated with RT from 1977 to 2014 were selected for the study, since endowed with histological diagnosis on the amount of 181 extensive BCC...
January 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28129526/addition-of-androgens-improves-survival-in-elderly-patients-with-acute-myeloid-leukemia-a-goelams-study
#14
Arnaud Pigneux, Marie C Béné, Philippe Guardiola, Christian Recher, Jean-Francois Hamel, Mathieu Sauvezie, Jean-Luc Harousseau, Olivier Tournilhac, Francis Witz, Christian Berthou, Martine Escoffre-Barbe, Denis Guyotat, Nathalie Fegueux, Chantal Himberlin, Mathilde Hunault, Martine Delain, Bruno Lioure, Eric Jourdan, Frederic Bauduer, Francois Dreyfus, Jean-Yves Cahn, Jean-Jacques Sotto, Norbert Ifrah
Purpose Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes. Androgens, used in the treatment of aplastic anemia, have been reported to block proliferation of and initiate differentiation in AML cells. We report the results of a multicenter, phase III, randomized open-label trial exploring the benefit of adding androgens to maintenance therapy in patients 60 years of age or older. Patients and Methods A total of 330 patients with AML de novo or secondary to chemotherapy or radiotherapy were enrolled in the study...
February 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28126268/-colorectal-cancer-in-the-elderly-surgical-treatment-chemotherapy-and-contribution-from-geriatrics
#15
Pilar Sáez-López, Elena Filipovich Vegas, Javier Martinez Peromingo, Sonia Jimenez Mola
Age is the biggest risk factor for colorectal cancer, with 70% of the cases in patients over 70 years old. For this reason, a review is presented on the surgical treatment and chemotherapy of cancer of colon and rectum in the elderly. A search was performed in PubMed, including words such as elderly, surgery, colorectal cancer, chemotherapy, radiotherapy, and oncogeriatrics, and review articles and originals on treatment of colorectal cancer in the elderly were selected. A narrative form was developed from the latest evidence with the results obtained on the treatment of this pathology...
January 23, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28115960/non-melanoma-skin-cancer-treated-with-high-dose-rate-brachytherapy-a-review-of-literature
#16
REVIEW
Durim Delishaj, Agata Rembielak, Bruno Manfredi, Stefano Ursino, Francesco Pasqualetti, Concetta Laliscia, Francesca Orlandi, Riccardo Morganti, Maria Grazia Fabrini, Fabiola Paiar
PURPOSE: The incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. There are different treatment options and surgical excision is the most frequent treatment due to its low rates of recurrence. Radiotherapy is an effective alternative of surgery, and brachytherapy (BT) might be a better therapeutic option due to high radiation dose concentration to the tumor with rapid dose fall-off resulting in normal tissues sparing. The aim of this review was to evaluate the local control, toxicity, and cosmetic outcomes in NMSC treated with high-dose-rate BT (HDR-BT)...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28104300/challenges-and-opportunities-in-primary-cns-lymphoma-a-systematic-review
#17
REVIEW
Mariana N Kerbauy, Fabio Y Moraes, Benjamin H Lok, Jennifer Ma, Lucila N Kerbauy, Daniel E Spratt, Fabio P S Santos, Guilherme F Perini, Alejandro Berlin, Caroline Chung, Nelson Hamerschlak, Joachim Yahalom
BACKGROUND: Historically, high-dose methotrexate (HD-MTX) plus consolidation chemotherapy and/or whole brain radiotherapy (WBRT) has been the gold standard on Primary Central Nervous System Lymphoma (PCNSL) management. We sought to examine and summarize the data, on clinical trial (CT) setting, investigating multi-modality treatment to PCNSL. METHODS: We performed a systematic review of electronic databases (Medline, EMBASE, Cochrane Database and clinicaltrials...
January 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28100948/malignant-proliferating-trichilemmal-tumour-of-the-scalp-with-intra-cranial-extension-and-lung-metastasis-a-case-report
#18
Lancelot Lobo, Amol Dilip Amonkar, V V S M Kumar Dontamsetty
Malignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. However at times, the tumour has an aggressive clinical course and a propensity for distant metastasis. We report a case of a 29-year-old male who presented with a scalp swelling...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28095342/orthognathic-surgery-during-breast-cancer-treatment-a-case-report
#19
Tsuyoshi Shimo, Norie Yoshioka, Masahiro Nakamura, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Masanori Masui, Mayumi Yao, Koji Kishimoto, Shoko Yoshida, Akiyoshi Nishiyama, Hiroshi Kamioka, Akira Sasaki
INTRODUCTION: In recent years, patients with orthognathic surgery in middle-aged and elderly people have come to be a more frequent occurrence. Breast cancer is the most frequently diagnosed cancer in woman worldwide, and its prevalence rate is steadily increasing. PRESENTATION OF CASE: We report a case of a 47-year-old Japanese woman in whom left-side breast cancer (Stage 1) was unexpectedly found just before orthognathic surgery in April 2012. Breast-conserving surgery was performed (estrogen receptor+, progesterone receptor+, HER2 -, surgical margin+, sentinel lymph node +) that May...
January 3, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28091898/the-outcomes-of-radiotherapy-and-factors-that-predict-overall-survival-in-elderly-patients-with-esophageal-squamous-cell-carcinoma
#20
H Yin, M E, H Zhang, C Wang
PURPOSE: The aim of this study was to evaluate radiotherapy in terms of both feasibility and efficacy for the treatment of 206 elderly patients (≥70 years) with unresectable ESCC and to investigate the factors that predict overall survival in those patients. METHODS: Totally, 206 elderly patients with esophageal cancer (≥70 years) treated with RT for ESCC in the Harbin Medical University Affiliated Tumor Hospital were retrospectively enrolled. Radiation treatment results and side effects were evaluated...
January 13, 2017: Clinical & Translational Oncology
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