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https://www.readbyqxmd.com/read/28544062/clinical-outcomes-of-stereotactic-body-radiotherapy-for-elderly-patients-with-hepatocellular-carcinoma
#1
Yuji Teraoka, Tomoki Kimura, Hiroshi Aikata, Kana Daijo, Mitsutaka Osawa, Fumi Honda, Yuki Nakamura, Kei Morio, Reona Morio, Masahiro Hatooka, Tomoki Kobayashi, Takashi Nakahara, Eisuke Murakami, Yuko Nagaoki, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Yasushi Nagata, Kazuaki Chayama
BACKGROUND/AIM: To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of hepatocellular carcinoma (HCC) in elderly patients. METHODS: From 2008 to 2015, 117 patients with HCC (≦3 nodules, ≦30 mm in diameter, Child-Pugh score ≦7, no vascular or extracellular metastasis) were treated with SBRT at our hospital. We evaluated overall survival (OS), disease-free survival (DFS), local control, and adverse events. Patients were stratified according to age 75 years and older (elderly group, n = 54) and age younger than 75 years (young group, n = 63)...
May 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28542078/a-population-level-investigation-of-cancer-clinical-trials-participation-in-a-uk-region
#2
Conan B Donnelly, Amy C Wotherspoon, Melanie Morris, Richard H Wilson, Jingwen J Chen, Victoria Cairnduff, Eileen Morgan, Amy Devlin, Anna T Gavin
The aim of this study was to document cancer trial participation since establishment of the Northern Ireland Cancer Trials Network and investigate population and disease factors associated with trial participation. An independent cohort of over 51 000 cancer patients from the Northern Ireland Cancer Registry covering the same population (2007-2012) was linked to a database of 1316 interventional cancer trial participants in a UK region. The primary outcome measure was participation in an intervention clinical trial...
May 24, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28537491/could-radiotherapy-be-omitted-in-elderly-patients-receiving-breast-conserving-surgery
#3
Marco Krengli, Carla Pisani
No abstract text is available yet for this article.
May 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28527010/glioblastoma-multiforme-gbm-in-the-elderly-initial-treatment-strategy-and-overall-survival
#4
Scott M Glaser, Michael J Dohopolski, Goundappa K Balasubramani, John C Flickinger, Sushil Beriwal
The EORTC trial which solidified the role of external beam radiotherapy (EBRT) plus temozolomide (TMZ) in the management of GBM excluded patients over age 70. Randomized studies of elderly patients showed that hypofractionated EBRT (HFRT) alone or TMZ alone was at least equivalent to conventionally fractionated EBRT (CFRT) alone. We sought to investigate the practice patterns and survival in elderly patients with GBM. We identified patients age 65-90 in the National Cancer Data Base (NCDB) with histologically confirmed GBM from 1998 to 2012 and known chemotherapy and radiotherapy status...
May 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28490931/treatment-and-outcomes-for-glioblastoma-in-elderly-compared-with-non-elderly-patients-a-population-based-study
#5
E R Morgan, A Norman, K Laing, M D Seal
PURPOSE: Elderly patients make up a large percentage of the individuals newly diagnosed with glioblastoma (gbm), but they face particular challenges in tolerating standard therapy, and compared with younger patients, they experience significantly shorter survival. We set out to compare clinical characteristics, treatment patterns, and outcomes in a non-elderly group (<65 years) and an elderly group (≥65 years) of patients diagnosed with gbm. METHODS: This retrospective population-based study used a province-wide cancer registry to identify patients with a new diagnosis of gbm within a 6-year period (2006-2012)...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28485335/radical-chemo-irradiation-using-intensity-modulated-radiotherapy-for-locally-advanced-head-and-neck-cancer-in-elderly-patients-experience-from-a-tertiary-care-center-in-south-india
#6
J R Chalissery, P C Sudheeran, K M Varghese, K Venkatesan
OBJECTIVE: To assess the feasibility, tolerance and response of radical chemo irradiation using Intensity modulated Radiotherapy [IMRT] in elderly patients [age >65] with locally advanced head and neck cancer. MATERIAL AND METHODS: Patients aged 65 and above [range 65 to 84years] registered in oncology outpatient unit in our institution between December 2011 to 2014, with stage III and IV head and neck cancer were treated with radical dose of radiotherapy using IMRT and concurrent chemotherapy with cisplatin 40mg/sq...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28454549/does-age-really-matter-radiotherapy-in-elderly-patients-with-glioblastoma-the-munich-experience
#7
Christoph Straube, Hagen Scherb, Jens Gempt, Stefanie Bette, Claus Zimmer, Friederike Schmidt-Graf, Jürgen Schlegel, Bernhard Meyer, Stephanie E Combs
BACKGROUND: Glioblastoma is usually diagnosed around the age of 60-70 years. Patients older than 65 years are frequently described as "elderly". Several trials with monotherapy have established treatment regimens that offer therapies with reduced side effects but reduced efficacy. We analysed the outcome of elderly glioblastoma patients treated at our facility. METHODS: We performed a retrospective analysis of 62 consecutive patients older than 65 years treated for a primary glioblastoma at our facility from 2009 to 2015...
April 28, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28449472/definitive-concurrent-chemoradiotherapy-with-s-1-and-cisplatin-in-elderly-esophageal-squamous-cell-carcinoma-patients
#8
Hongqing Wang, Gang Li, Lifang Chen, Yuxia Duan, Chunpeng Zou, Chunhong Hu
BACKGROUND: To evaluate the feasibility and efficiency of definitive concurrent chemoradiotherapy (dCRT) with S-1 and cisplatin for elderly esophageal squamous cell carcinoma (ESCC) patients. METHODS: Fifty-six elderly patients were included from January 2012 to December 2014. Patients received S-1 (tegafur/gimeracil/oteracil) and cisplatin at doses of 70 mg/m(2)/day for two weeks and 75 mg/m(2) on day 1, respectively, every 3 weeks. Radiotherapy was delivered at a dose of 180-200 cGy per day to a total dose of 54 Gy...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28447170/surgery-or-stereotactic-body-radiotherapy-for-elderly-stage-i-lung-cancer-a-propensity-score-matching-analysis
#9
Takuro Miyazaki, Takuya Yamazaki, Daisuke Nakamura, Shuntaro Sato, Naoya Yamasaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Ryotaro Kamohara, Go Hatachi, Takeshi Nagayasu
PURPOSE: The aim of this study was to compare the outcomes of surgery and stereotactic body radiotherapy (SBRT) for elderly clinical stage I non-small cell lung cancer (NSCLC) patients. METHODS: Patients ≥80 years of age with clinical stage I NSCLC between August 2008 and December 2014 were treated either surgery or SBRT. Propensity score matching was performed to reduce bias in various clinicopathological factors. RESULTS: Surgery was performed in 57 cases and SBRT in 41 cases...
April 26, 2017: Surgery Today
https://www.readbyqxmd.com/read/28441373/cost-effectiveness-analysis-of-interventions-to-reduce-risk-of-aspiration-in-elderly-cancer-survivors-residing-in-skilled-nursing-facilities
#10
S Mantravadi
BACKGROUND: Aspiration can occur in patients of any age group, but it can be prevented. The primary population at risk is made up of survivors of cancer because of their increased risk of mucositis, mucosal atrophy, and dysphagia associated with chemotherapy, radiotherapy, and the disease process itself. The rate of incidence of aspiration cannot be quantified, because minor cases of aspiration often go unreported. Sequelae ensuing from aspirations can include pneumonia, end-stage kidney disease, dialysis, and death...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28440040/hypofractionated-short-course-radiotherapy-in-elderly-patients-with-glioblastoma-multiforme-an-analysis-of-the-national-cancer-database
#11
Kimberley S Mak, Ankit Agarwal, Muhammad M Qureshi, Minh Tam Truong
For elderly patients with glioblastoma multiforme (GBM), randomized trials have shown similar survival with hypofractionated short-course radiotherapy (SCRT) compared to conventionally fractionated long-course radiotherapy (LCRT). We evaluated the adoption of SCRT along with associated factors and survival in a national patient registry. Using the National Cancer Data Base (NCDB), we identified patients aged ≥70 years with GBM, diagnosed between 1998 and 2011, who received SCRT (34-42 Gy in 2.5-3.4 Gy fractions), or LCRT (58-63 Gy in 1...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28439842/controversies-in-the-multimodality-management-of-locally-advanced-rectal-cancer
#12
REVIEW
Robert Díaz Beveridge, Dilara Akhoundova, Gema Bruixola, Jorge Aparicio
Neoadjuvant radiotherapy previous to radical surgery, both as short-course radiotherapy and as long-course radiotherapy combined with 5-FU-based chemotherapy (LCRCT), is routinely used in the management of locally advanced rectal cancer, with consistent benefits in the reduction in the local relapse risk. Unfortunately, survival benefits have been elusive to demonstrate with this approach, especially in the setting of radical surgery in the form of total mesorectal excision (TME). Concerns about over-treating early-stage patients and about the possible long-term side effects have also cast more doubts in a blanket approach of treating all patients with neoadjuvant radiotherapy, especially with LCRCT...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28435647/helical-tomotherapy%C3%A2-is-a-safe-and-feasible-technique-for-total-scalp-irradiation
#13
Francesco Cuccia, Vanessa Figlia, Antonella Palmeri, Francesco Verderame, Antonio Lo Casto, Mariella Mannino, Giuseppe Ferrera
Angiosarcoma of the scalp is a rare aggressive tumor that affects elderly patients. Chemoradiation is the treatment of choice for multicentric and extensive disease. The shape of the scalp represents a dosimetric challenge in terms of achieving a homogeneous concave dose distribution with coverage of the entire target volume and an acceptable organs-at-risk sparing. We report a case of an 81-year-old man with a multifocal angiosarcoma of the scalp treated with Helical TomoTherapy® (Accuray Inc., Sunnyvale, CA, USA) intensity modulated radiotherapy...
March 24, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28432587/rituximab-methotrexate-procarbazine-vincristine-and-intensified-cytarabine-consolidation-for-primary-central-nervous-system-lymphoma-pcnsl-in-the-elderly-a-loc-network-study
#14
Caroline Houillier, Hervé Ghesquières, Cécile Chabrot, Carole Soussain, Guido Ahle, Sylvain Choquet, Emmanuelle Nicolas-Virelizier, Jacques-Olivier Bay, Jacques Vargaftig, Claude Gaultier, Valérie Touitou, Nadine Martin-Duverneuil, Nathalie Cassoux, Magali Le Garff-Tavernier, Myrto Costopoulos, Pierre Faurie, Khê Hoang-Xuan
Primary CNS lymphoma (PCNSL) is chemosensitive to high-dose methotrexate-based chemotherapy. However, responses in the elderly are short-lasting and outcome is poor. Given that radiotherapy and intensive chemotherapy expose elderly to severe toxicities, alternative consolidation approaches need to be evaluated. In this multicenter study, we retrospectively analyzed consecutive patients with newly-diagnosed PCNSL, aged >60, treated with a (R)-MPV-AAA regimen. The regimen consisted of three 28-day cycles of methotrexate (3...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28415814/concurrent-chemo-radiotherapy-with-s-1-as-an-alternative-therapy-for-elderly-chinese-patients-with-non-metastatic-esophageal-squamous-cancer-evidence-based-on-a-systematic-review-and-meta-analysis
#15
REVIEW
Guo-Min Song, Xu Tian, Xiao-Ling Liu, Hui Chen, Jian-Guo Zhou, Wei Bian, Wei-Qing Chen
OBJECTIVE: This systematic review and meta-analysis aims to systematically assess the effects of concurrent chemo-radiotherapy (CRT) compared with radiotherapy (RT) alone for elderly Chinese patients with non-metastatic esophageal squamous cancer. METHODS: We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), China Biomedical Literature Database (CBM), and China National Knowledge Infrastructure (CNKI) databases. We retrieved randomized controlled trials on concurrent CRT with Gimeraciland Oteracil Porassium (S-1) compared with RT alone for aged Chinese patients with non-metastatic esophageal squamous cancer performed until August 2016...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28391871/tamoxifen-with-radiotherapy-compared-with-tamoxifen-alone-in-elderly-women-with-early-stage-breast-cancer-treated-with-breast-conserving-surgery-a-systematic-review-and-meta-analysis
#16
REVIEW
Tyler R Chesney, Jennifer Xin Yin, Nikoo Rajaee, Andrea C Tricco, Anthony W Fyles, Sergio A Acuna, Adena S Scheer
BACKGROUND: Our aim was to assess the effect of adjuvant radiotherapy on recurrence and survival for elderly women (≥70) with early-stage hormone receptor-positive breast cancer treated with breast conserving surgery (BCS) and Tamoxifen. MATERIALS AND METHODS: MEDLINE, EMBASE, and Evidence-Based Medicine Reviews were systematically searched through August 12, 2016 for randomized controlled trials (RCTs) comparing radiotherapy to no radiotherapy and presenting outcomes for women ≥70years...
April 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28389722/undertreatment-trend-in-elderly-lung-cancer-patients-in-brazil
#17
Guilherme Jorge Costa, Maria Júlia Gonçalves de Mello, Carlos Gil Ferreira, Luiz Claudio Santos Thuler
PURPOSE: Elderly patients with lung cancer tend to be undertreated in comparison to younger patients. The objective of this study is to compare treatment modalities offered to lung cancer patients from 70 years of age or more with patients under 70. METHODS: For this study, an analytical cross-sectional epidemiological study conducted with data from the Brazilian hospital-based cancer registries between the years 2000 and 2011. In addition, odds ratios (OR) were calculated, with a 95% confidence intervals (95% CI), in conjunction with the construction of a logistic regression model...
April 7, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28378194/management-of-gbm-a-problem-of-local-recurrence
#18
REVIEW
John P Kirkpatrick, Nadia N Laack, Helen A Shih, Vinai Gondi
Forty years ago, adjuvant treatment of patients with GBM using fractionated radiotherapy following surgery was shown to substantially improve survival compared to surgery alone. However, even with the addition of temozolomide to radiotherapy, overall survival is quite limited and local failure remains a fundamental problem, despite multiple attempts to increase dose to the tumor target. This review presents the historical background and clinical rationale leading to the current standard of care consisting of 60 Gy total dose in 2 Gy fractions to the MRI-defined targets in younger, high performance status patients and more hypofractionated regimens in elderly and/or debilitated patients...
April 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28366575/timed-get-up-and-go-test-and-geriatric-8-scores-and-the-association-with-chemo-radiation-therapy-noncompliance-and-acute-toxicity-in%C3%A2-elderly-cancer-patients
#19
Judith G Middelburg, Mirjam E Mast, Maaike de Kroon, Jan J Jobsen, Tom Rozema, Huub Maas, Elizabet A Baartman, Debby Geijsen, Annija H van der Leest, Desirée J van den Bongard, Judith van Loon, Tom Budiharto, Jan Willem Coebergh, Mieke J Aarts, Henk Struikmans
PURPOSE: To investigate whether the Geriatric 8 (G8) and the Timed Get Up and Go Test (TGUGT) and clinical and demographic patient characteristics were associated with acute toxicity of radiation therapy and noncompliance in elderly cancer patients being irradiated with curative intent. METHODS AND MATERIALS: Patients were eligible if aged ≥65 years and diagnosed with breast, non-small cell lung, prostate, head and neck, rectal, or esophageal cancer, and were referred for curative radiation therapy...
January 29, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28360434/locally-advanced-breast-cancer-in-elderly-patients
#20
Jana Hornova, Zbynek Bortlicek, Petra Majkova, Jitka Abrahamova, Drahomira Kordikova, Zuzana Donatova, Martin Kupec, Ludmila Boublikova, Josef Dvorak, Radek Zapletal, Tomas Buchler
BACKGROUND: Although locally advanced breast cancer (LABC) is more common in the elderly population, there is little data on the clinical characteristics and survival of these patients. The aim of the present study was to compare different factors affecting survival in elderly patients with LABC. METHODS: Retrospective analysis was carried out on a cohort of 80 patients aged 70 to 96 years, diagnosed with LABC defined as T3 N1, T4 N0, any N2 or N3, and M0. The prognostic impact of selected clinical parameters including age, comorbidities, tumour grade, HER2 status, tumour stage, local therapies, and systemic treatments was studied...
March 30, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
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