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https://www.readbyqxmd.com/read/29216832/a-long-surviving-patient-with-advanced-esophageal-basaloid-squamous-cell-carcinoma-treated-only-with-radiotherapy-case-report-and-literature-review
#1
Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Homma Taku, Moritaka Ohhara, Toshirou Takimoto, Yoshiaki Tanaka
BACKGROUND: Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare malignant disease. Advanced EBSCC (AEBSCC) has a poorer prognosis than the more common esophageal squamous cell carcinoma, but no treatment policy has yet been established. This is the first reported case with AEBSCC treated only with radiotherapy. Thus, our long-surviving patient merits consideration. We therefore reviewed cases with the same stage of AEBSCC for further investigation. CASE PRESENTATION: An 85-year-old man with a chief complaint of difficulty swallowing foods was diagnosed with AEBSCC, cT3N1M0, stage III, by thorough examination...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29212499/radiotherapy-plus-temozolomide-in-elderly-patients-with-glioblastoma-a-real-life-report
#2
J Biau, E Chautard, E De Schlichting, G Dupic, B Pereira, A Fogli, M Müller-Barthélémy, P Dalloz, T Khalil, A F Dillies, X Durando, C Godfraind, P Verrelle
BACKGROUND: The optimization of the management for elderly glioblastoma patients is crucial given the demographics of aging in many countries. We report the outcomes for a "real-life" patient cohort (i.e. unselected) comprising consecutive glioblastoma patients aged 70 years or more, treated with different radiotherapy +/- temozolomide regimens. METHODS: From 2003 to 2016, 104 patients ≥ 70 years of age, consecutively treated by radiotherapy for glioblastoma, were included in this study...
December 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29209874/utilization-of-hypofractionated-radiotherapy-in-treatment-of-glioblastoma-multiforme-in-elderly-patients-not-receiving-adjuvant-chemoradiotherapy-a-national-cancer-database-analysis
#3
Brian Bingham, Chirayu G Patel, Eric T Shinohara, Albert Attia
To assess the utilization and outcomes of adjuvant monotherapy with hypofractionated radiation (RT) among elderly patients not receiving traditional adjuvant chemoradiotherapy (cRT) for glioblastoma multiforme (GBM). A retrospective analysis using the National Cancer Data Base with GBM patients aged 65 years or older treated between 2005 and 2012 was conducted. Patients who underwent hypofractionated RT (40 Gy), conventional RT (60 Gy), chemotherapy, or best supportive care alone were included. Statistical methods included logistic regression for utilization and Cox regression for survival analysis...
December 5, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29207720/locally-aggressive-primary-intraosseous-paraganglioma-of-sacrum
#4
Parampalli Srinivas Srilatha, Lakshmi Rao
Primary Intraosseous Paraganglioma (PGL) of sacrum is highly uncommon. Few of the spinal PGL reported were mostly intradural mass. Paraganglionic tissue is usually not present in the bone. So far, only seven cases of primary intraosseous sacral PGL have been reported in the literature. There are no dependable prognostic histological features to differentiate benign from malignant PGL. The only unequivocal criterion for malignancy is metastasis to an organ where paraganglionic tissue is normally not present...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29184679/outcomes-of-adjuvant-radiotherapy-and-lymph-node-resection-in-elderly-patients-with-pancreatic-cancer-treated-with-surgery-and-chemotherapy
#5
Jessica Frakes, Eric A Mellon, Gregory M Springett, Pamela Hodul, Mokenge P Malafa, William J Fulp, Xiuhua Zhao, Sarah E Hoffe, Ravi Shridhar, Kenneth L Meredith
Background: We sought to determine the effects of post-operative radiation therapy (PORT) and lymph node resection (LNR) on survival in patients ≥70 years with pancreatic cancer treated with surgery and chemotherapy. Methods: An analysis of patients ≥70 years with surgically resected pancreatic cancer who received chemotherapy from the SEER database between 2004-2008 was performed to determine association of PORT and LNR on survival. Results: We identified 961 patients who met inclusion criteria...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29159793/curative-radiation-therapy-for-very-elderly-bladder-cancer-patients-with-localized-disease
#6
M Bonet, T Bonfill, M Nuñez, L De Verdonces, E Mur, E Gallardo, L Fernandez-Morales, A Aguilar, J Prats, M Arenas
PURPOSE: To report the outcomes of a cohort of very elderly muscle-invasive bladder cancer (MIBC) patients treated with contemporary 3D-conformal radiation therapy (3D-CRT) with or without concurrent chemotherapy, after transurethral resection of bladder tumor (TURBT). METHODS: From February 2010 to January 2014, a total of 41 patients older than 75 years, with T2-3 N0-1 high-grade MIBC, a Karnofsky index (KI) of at least 90% and/or a Barthel scale score of at least 95, were treated with TURBT followed by radiotherapy (RT) with or without chemotherapy, and were prospectively followed-up...
November 20, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29158796/radiotherapy-alone-or-concurrent-chemoradiation-for-esophageal-squamous-cell-carcinoma-in-elderly-patients
#7
Lina Zhao, Yongchun Zhou, Haitao Pan, Yutian Yin, Guangjin Chai, Yunfeng Mu, Feng Xiao, Steven H Lin, Mei Shi
Purpose: The reported data of elderly ESCC are rather limited and there is a lack of information to guide treatment decisions for elderly patients with esophageal cancer. This study aims to identify the efficacy and factors for optimal treatment approaches for elderly esophageal squamous cell carcinoma (ESCC) treated with radiotherapy (RT) alone or concurrent chemoradiation (CCRT). Methods: This study included 184 I-III elderly ESCC patients aged ≥70 years treated by oral single agent CCRT (sCCRT) or double agents CCRT (dCCRT) or RT alone at a single institution in China...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29155480/intensity-modulated-radiotherapy-for-elderly-patients-with-nasopharyngeal-carcinoma
#8
Caineng Cao, Qiaoying Hu, Xiaozhong Chen
BACKGROUND: The purpose of this study was to evaluate the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for elderly patients with nasopharyngeal carcinoma (NPC). METHODS: Fifty-two patients treated with IMRT were eligible for study inclusion. Comorbidity was rated using the Adult Comorbidity Evaluation-27 (ACE-27) system. RESULTS: Twenty-six patients (50.0%) had an ACE-27 score of 1; and 6 (11.5%) had an ACE-27 score of 2...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29152068/age-associated-and-therapy-induced-alterations-in-the-cellular-microenvironment-of-experimental-gliomas
#9
Hannah Schneider, Birthe Lohmann, Hans-Georg Wirsching, Kathy Hasenbach, Elisabeth J Rushing, Karl Frei, Martin Pruschy, Ghazaleh Tabatabai, Michael Weller
The poor prognosis associated with advanced age in patients with glioblastoma remains poorly understood. Glioblastoma in the elderly has been particularly associated with vascular endothelial growth factor (VEGF)-dependent angiogenesis, and early uncontrolled studies suggested that the anti-angiogenic agent bevacizumab (BEV), an antibody to VEGF, might be preferentially active in this patient population. Accordingly, we explored host age-dependent differences in survival and benefit from radiotherapy (RT) or BEV in syngeneic mouse glioma models...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137320/a-phase-ii-study-of-s-1-with-concurrent-radiotherapy-in-elderly-patients-with-esophageal-cancer
#10
Yongling Ji, Xianghui Du, Ye Tian, Liming Sheng, Lei Cheng, Ying Chen, Guoqing Qiu, Xia Zhou, Wuan Bao, Danhong Zhang, Ming Chen
Background: Concurrent chemoradiotherapy (CCRT) using conventional platinum-based doublets are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. We previously reported a phase I trial of CCRT using S-1, an oral 5-fluorouracil derivative, which yielded well safe and active outcomes. Methods: Patients with histologically confirmed esophageal cancer, who were age of 70 years or older with performance status (PS) score of 0-2 or age of 66 to 69 with PS score of 2, were eligible for this Phase II trial...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132118/primary-malignant-melanoma-of-the-female-urethra-report-of-a-rare-neoplasm-of-the-urinary-tract
#11
Namita Bhutani, Pradeep Kajal, Devendra Pawar
INTRODUCTION: Melanoma is a malignant tumor that can affect any area of the anatomical economy. Its occurance in the female urethra is extremely rare. We report a case of primary malignant urethral melanoma developed in an elderly female patient. PRESENTATION OF CASE: A 70 years old female presented with dysuria, poor stream, gross haematuria, intermittent blood spots, and a painful mass. On physical examination, there were no suspicious lesions on the skin. On external genital examination, a lesion at the level of the urethral meatus was observed...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29124650/correction-to-which-elderly-newly-diagnosed-glioblastoma-patients-can-benefit-from-radiotherapy-and-temozolomide-a-perno-prospective-study
#12
Enrico Franceschi, Roberta Depenni, Alexandro Paccapelo, Mario Ermani, Marina Faedi, Carmelo Sturiale, Maria Michiara, Franco Servadei, Giacomo Pavesi, Benedetta Urbini, Anna Pisanello, Girolamo Crisi, Michele A Cavallo, Claudio Dazzi, Claudia Biasini, Federica Bertolini, Claudia Mucciarini, Giuseppe Pasini, Agostino Baruzzi, Alba A Brandes
The members of the PERNO Study Group were not individually captured in the metadata of the original publication. They are included in the metadata of this publication.
November 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29118232/healthcare-utilization-and-costs-during-the-initial-phase-of-care-among-elderly-women-with-breast-cancer
#13
Ami Vyas, S Suresh Madhavan, Usha Sambamoorthi, Xiaoyun Lucy Pan, Michael Regier, Hannah Hazard, Sita Kalidindi
Background: Understanding the patterns of healthcare utilization and costs during the initial phase of care (12 months after breast cancer [BC] diagnosis) in older women (aged ≥65 years) is crucial in the allocation of Medicare resources. The objective of this study was to determine healthcare utilization and costs during the initial phase of care in older, female, Medicare fee-for-service beneficiaries diagnosed with BC, and to determine the factors associated with higher costs. Methods: A retrospective observational study using the SEER-Medicare linked database was conducted in 69,307 women aged ≥66 years diagnosed with primary incident BC in 2003-2009 to determine healthcare utilization, average costs, and costs for specific services during the initial phase of care...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29113729/intensified-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectal-cancer-in-elderly-patients-toxicity-disease-control-and-survival-outcomes
#14
Francesca De Felice, Karen Llange, Filippo Rubini, Nadia Bulzonetti, Rossella Caiazzo, Daniela Musio, Vincenzo Tombolini
INTRODUCTION: We report the treatment compliance, toxicity rates, and long-term clinical outcomes of elderly patients who received intensified neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). PATIENTS AND METHODS: We identified a retrospective cohort of patients aged ≥ 70 years with LARC who received intensified neoadjuvant CRT, followed by surgery and adjuvant chemotherapy, from 2007 to 2014. Intensified neoadjuvant CRT consisted of radiotherapy (total dose, 50...
October 16, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29109863/pattern-of-gynaecological-malignancies-in-south-western-region-of-pakistan-an-overview-of-12-years
#15
Hina Manzoor, Hamida Naheed, Khushnaseeb Ahmad, Shehla Iftikhar, Muhammad Asif, Jamila Shuja, Neelam Sultan, Irfan Ali, Syed Inayatullah, Yasir Hayat Khan
Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%)...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29108382/clinicopathologic-features-and-prognostic-factors-for-patients-with-colorectal-cancer-who-are-75-years-and-older
#16
Mingfang Zhao, Hans Liu, Yanqing Tang, Xin Meng, Jun Yu, Qi Wang, Qiao Zhou, Sean X Leng, Haiyan Zhang
Colorectal cancer (CRC) is common and can be considered as a disease of older adults. About one half of the cases were diagnosed in patients over 70 years of age. Decision-making about treatment for these older patients can be complicated by age-related physiological changes, impaired functional status, limited social support, and comorbidities. Many trials excluded patients using an upper limit of 75 years of age. Little is known about prognostic factors in patients who are over this age limit. In this study, we conducted an analysis in the Surveillance, Epidemiology and End Results (SEER) database to identify specific clinicopathologic features and prognostic factors for these vulnerable cancer patients (N= 293,616)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103743/elderly-patients-affected-by-head-and-neck-squamous-cell-carcinoma-unfit-for-standard-curative-treatment-is-de-intensified-hypofractionated-radiotherapy-a-feasible-strategy
#17
Pierluigi Bonomo, Isacco Desideri, Mauro Loi, Monica Lo Russo, Emanuela Olmetto, Virginia Maragna, Giulio Francolini, Camilla Delli Paoli, Roberta Grassi, Donato Pezzulla, Daniela Greto, Icro Meattini, Lorenzo Livi
OBJECTIVES: The aim of our work was to report on the clinical outcome of a moderately hyprofractionated radiotherapy regimen in elderly patients affected by head and neck squamous cell carcinoma (HNSCC). MATERIAL AND METHODS: HNSCC aged ≥65 deemed unsuitable for curatively-intended concurrent chemo-radiotherapy or high-dose radiotherapy by clinical judgement were further evaluated with the Geriatric 8 (G8) questionnaire and Charlson comorbidity index (CCI). In case of a G8 score ≤14, a de-intensified radiation schedule of 40 Gy delivered in 16 fractions was prescribed...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29102167/population-based-results-of-chemoradiotherapy-for-limited-stage-small-cell-lung-cancer-in-the-netherlands
#18
R Damhuis, J Widder, S Senan
AIMS: Treatment guidelines for limited stage small cell lung cancer (LS-SCLC) favour early concurrent chemoradiotherapy (CRT). Little is known about contemporary, real-world treatment patterns and outcome. We evaluated population-based practice patterns of CRT and corresponding survival in the Netherlands, focusing on the impact of the 2011 national guidelines recommending use of twice-daily (BID) radiotherapy, and treatment outcomes in elderly patients. MATERIALS AND METHODS: Data for 1635 patients with LS-SCLC treated with CRT from 2010 to 2014 were retrieved from the Netherlands Cancer Registry...
October 25, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29081442/glioblastoma-treatment-in-the-elderly
#19
Masaki Okada, Keisuke Miyake, Takashi Tamiya
Although current treatment advances prolong patient survival, treatment for glioblastoma (GBM) in the elderly has become an emerging issue. The definition of "elderly" differs across articles; GBM predominantly occurs at an age ≥65 years, and the prognosis worsens with increasing age. Regarding molecular markers, isocitrate dehydrogenase (IDH) mutations are less common in the elderly with GBM. Meanwhile, O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation has been identified in approximately half of patients with GBM...
October 30, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29080109/optimal-therapies-for-newly-diagnosed-elderly-patients-with-glioblastoma
#20
REVIEW
Sarah Ironside, Sunit Das, Arjun Sahgal, Claire Moroney, Todd Mainprize, James R Perry
Newly diagnosed elderly patients (age > 65-70 years) with glioblastoma should be treated with a patient-centred approach by a multi-disciplinary team. Chronological age alone should not be considered as a contraindication to treatment with maximal safe surgical resection. A 3-week course of adjuvant radiation and chemotherapy is appropriate in selected elderly patients with favourable Karnofsky performance status (KPS) who cannot tolerate a longer 6-week course of fractionated radiotherapy. The presence or absence of 0(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation can be used to guide clinical decision-making as both prognostic and predictive biomarkers...
October 27, 2017: Current Treatment Options in Oncology
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