Atsushi Saito, Haruka Murata, Kazuhei Niitani, Junpei Nagasaki, Atsuki Otoda, Yusuke Chujo, Junko Yanagida, Naoya Nishitani, Satoshi Deyama, Katsuyuki Kaneda
Various stressors potentiate the rewarding effects of cocaine and contribute to cocaine cravings. However, it remains unclear whether psychosocial stress enhances the rewarding effects of cocaine. Accordingly, this study employed a cocaine-conditioned place preference (CPP) paradigm combined with social defeat (SD) exposure to investigate the effects of acute SD stress on cocaine reward in male mice. We found that SD stress immediately before the posttest significantly increased cocaine CPP, and systemic blockade of α1 adrenoceptors, but not β adrenoceptors, suppressed this increase...
October 13, 2023: Neuropharmacology