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Silodosin

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https://www.readbyqxmd.com/read/29778706/validated-stability-indicating-spectrophotometric-methods-for-the-determination-of-silodosin-in-the-presence-of-its-degradation-products
#1
Shereen A Boltia, Mohammed Abdelkawy, Taghreed A Mohammed, Nahla N Mostafa
Five simple, rapid, accurate, and precise spectrophotometric methods are developed for the determination of Silodosin (SLD) in the presence of its acid induced and oxidative induced degradation products. Method A is based on dual wavelength (DW) method; two wavelengths are selected at which the absorbance of the oxidative induced degradation product is the same, so wavelengths 352 and 377 nm are used to determine SLD in the presence of its oxidative induced degradation product. Method B depends on induced dual wavelength theory (IDW), which is based on selecting two wavelengths on the zero-order spectrum of SLD where the difference in absorbance between them for the spectrum of acid induced degradation products is not equal to zero so through multiplying by the equality factor, the absorption difference is made to be zero for the acid induced degradation product while it is still significant for SLD...
April 24, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29733797/comparison-of-safety-and-efficacy-of-silodosin-solifenacin-tadalafil-and-their-combinations-in-the-treatment-of-double-j-stent-related-lower-urinary-system-symptoms-a-prospective-randomized-trial
#2
Rohit Bhattar, Vinay Tomar, Sher Singh Yadav, Devendra Singh Dhakad
OBJECTIVE: To evaluate the efficacy and safety of silodosin, solifenacin, tadalafil and their combinations in reducing double J (DJ) stent-related symptoms (SRS). MATERIAL AND METHODS: A total of 335 patients who underwent DJ stenting and develop SRS at 1st week were randomized into eight groups. Ureteral stent symptom questionnaire (USSQ) and Quality of life (QOL) scores were noted in each group: Group A-Silodosin (8 mg OD)+ Solifenacin (10 mg OD)+ Tadalafil (5 mg OD), B - Silodosin 8 mg OD, C - Solifenacin 10 mg OD, D- Tadalafil 5 mg OD, E- Silodosin (8 mg OD) + Solifenacin (10 mg OD), F- Silodosin (8 mg 0D)+ Tadalafil (5 mg OD), G- Solifenacin (10 mg OD)+ Tadalafil (5 mg OD) and H-placebo...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29697376/efficacy-of-silodosin-urorec%C3%A2-in-the-treatment-of-benign-prostatic-hyperplasia-the-maximum-decrease-of-bladder-outlet-obstruction-index
#3
A Khamzin, R Frolov
One of the main causes of lower urinary tract symptoms in men over the age of 40 years old is benign prostatic hyperplasia (BPH), which according to the research is detected in 26.2% of men of this age group. The purpose of this study was to evaluate the efficacy of the use of silodosin (Urorec®) at dosage 8 mg once a day for relief of obstructive symptoms of BPH in men over 40 years old. From September 2016 till December 2017 144 men (residents of Almaty, the Republic of Kazakhstan) aged from 56 to 81 years old (63...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29680480/the-receipt-of-industry-payments-is-associated-with-prescribing-promoted-alpha-blockers-and-overactive-bladder-medications
#4
Parth K Modi, Ye Wang, Peter S Kirk, James M Dupree, Eric A Singer, Steven L Chang
OBJECTIVE: To determine the impact of physicians' financial relationships with the pharmaceutical industry on prescribing marketed alpha-blockers and overactive bladder medications. We also aim to examine if the number or total value of transactions is influential. MATERIALS AND METHODS: We linked the Open Payments Program database of industry payments to prescribers with Medicare Part D prescription data. We used binomial logistic regression to identify the association between receipt of industry payment and prescribing of marketed alpha-blockers (silodosin) and overactive bladder (OAB) medications (fesoterodine, solifenacin, and mirabegron)...
April 19, 2018: Urology
https://www.readbyqxmd.com/read/29617082/evaluation-of-apoptosis-indexes-in-currently-used-oral-alpha-blockers-in-prostate-a-pilot-study
#5
Mehmet Demir, Yigit Akin, Kubra Asena Kapakin Terim, Mehmet Gulum, Evren Buyukfirat, Halil Ciftci, Ercan Yeni
OBJECTIVES: Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker's apoptosis indexes together with their clinical effects. MATERIALS AND METHODS: Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015...
March 18, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29613909/new-alpha-blockers-to-treat-male-lower-urinary-tract-symptoms
#6
Eu Chang Hwang, Shreyas Gandhi, Jae H Jung
PURPOSE OF REVIEW: To date it is unclear whether the selectivity of new alpha-blockers to alpha-adrenergic receptor subtypes translates into more clinical benefits and less adverse effects in clinical practice. We performed a systematic review of the two new Abs silodosin and naftopidil. With the availability of numerous alpha-blockers to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia, the findings of this review will be highly relevant to the field of urology...
May 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29508437/inhibitory-effects-of-silodosin-on-the-bladder-mechanosensitive-afferent-activities-and-their-relation-with-bladder-myogenic-contractions-in-male-rats-with-bladder-outlet-obstruction
#7
Naoki Aizawa, Daiji Watanabe, Hiroshi Fukuhara, Tetsuya Fujimura, Haruki Kume, Yukio Homma, Yasuhiko Igawa
AIMS: We investigated the effects of silodosin, an α1A-adrenoceptor (AR) antagonist, on bladder function, especially on non-voiding contractions (NVCs), in a male rat model of bladder outlet obstruction (BOO) by evaluating cystometry (CMG) findings and bladder mechanosensitive single-unit afferent activities (SAAs), related with microcontractions, which may be similar with NVCs and to be of myogenic origin, in the rat model. METHODS: BOO was created by partial ligation of the posterior urethra...
March 6, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29502524/silodosin-8-mg-improves-benign-prostatic-obstruction-in-caucasian-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-enlargement-results-from-an-explorative-clinical-study
#8
Ferdinando Fusco, Massimiliano Creta, Nicola Longo, Francesco Persico, Marco Franco, Vincenzo Mirone
BACKGROUND: To preliminary investigate the effects of silodosin 8 mg once daily on obstruction urodynamic parameters and subjective symptoms in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement. METHODS: We performed a single-center, open-label, single-arm, post-marketing interventional clinical trial. Inclusion criteria were: Caucasian subjects aged ≥50 years waiting to undergo surgery for lower urinary tract symptoms suggestive of benign prostatic enlargement, international prostate symptom total score ≥ 13, international prostate symptom-quality of life score ≥ 3, prostate volume ≥ 30 ml, maximum urine flow rate ≤ 15 mL/s, bladder outlet obstruction index > 40...
March 5, 2018: BMC Urology
https://www.readbyqxmd.com/read/29475468/corrigendum-to-computed-tomography-findings-predicting-the-success-of-silodosin-for-medical-expulsive-therapy-of-ureteral-stones-kaohsiung-j-med-sci-33-6-2017-290-294
#9
Serdar Celik, Firat Akdeniz, Muge Afsar Yildirim, Ozan Bozkurt, Merve Gursoy Bulut, Mehmet Levent Hacihasanoglu, Omer Demir
No abstract text is available yet for this article.
March 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29394114/efficacy-of-newer-medications-for-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-a-systematic-review
#10
Roderick MacDonald, Michelle Brasure, Philipp Dahm, Carin M Olson, Victoria A Nelson, Howard A Fink, Michael C Risk, Bruce Rwabasonga, Timothy J Wilt
We conducted a systematic review to evaluate the efficacy and adverse effects of newer drugs used to treat lower urinary tract symptoms (LUTS). The drugs were either Food and Drug Administration (FDA) approved for benign prostatic hyperplasia (BPH) or not FDA approved for BPH but have been evaluated for treatment of BPH since 2008. We searched bibliographic databases through September 2017. We included randomized controlled trials (RCTs) lasting one month or longer published in English. Outcomes of interest were LUTS assessed by validated measures...
February 2, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29351556/testosterone-induced-benign-prostatic-hyperplasia-rat-and-dog-as-facile-models-to-assess-drugs-targeting-lower-urinary-tract-symptoms
#11
Jing Li, Yanxin Tian, Shimeng Guo, Haifeng Gu, Qianting Yuan, Xin Xie
Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, α1-adrenergic receptor (α1-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH...
2018: PloS One
https://www.readbyqxmd.com/read/29348991/medical-expulsive-therapy-for-distal-ureteral-stones-tamsulosin-versus-silodosin-in-the-turkish-population
#12
Ersan Arda, Basri Cakiroglu, Ilkan Yuksel, Esra Akdeniz, Gizem Cetin
Introduction Our aim was to contribute a study that includes a higher patient population to the limited number of studies comparing tamsulosin and silodosin in the treatment of distal ureteral stones. Material and methods Patients who presented with renal colic to the urology emergency clinic and were diagnosed with ureteral stones and followed-up with conservative treatment between January 2010 and January 2016 were retrospectively screened. According to the inclusion-exclusion criteria, the patients were divided into three groups...
November 15, 2017: Curēus
https://www.readbyqxmd.com/read/29236515/novel-lc-ms-ms-method-for-the-quantification-of-silodosin-and-its-metabolites-in-human-plasma
#13
Priyanka A Shah, Pranav S Shrivastav
No abstract text is available yet for this article.
December 13, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29201512/safety-and-efficacy-of-silodosin-and-tadalafil-in-ease-of-negotiation-of-large-ureteroscope-in-the-management-of-ureteral-stone-a-prosective-randomized-trial
#14
Rohit Bhattar, Vipin Jain, Vinay Tomar, Sher Singh Yadav
Objective: To evaluate the safety and efficacy of silodosin and tadalafil in ease of negotiation of large size ureteroscope (8/9.8 Fr) in the management of ureteral stone. Material and methods: Between June 2015 and May 2016, 86 patients presented with ureteral stone of size 6-15 mm were on consent randomly assigned to 1 of 3 outpatient treatment arms: silodosin (Group A), tadalafil (Group B), and placebo (Group C). After two weeks of therapy 67 patients underwent ureteroscopy, and ureteral orifice configuration, ureteroscopic negotiation, ureteral dilatation, operating time, procedural complication and drug related side effects were noted in each group...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29164564/role-of-silodosin-in-patients-with-luts-bpe-non-responding-to-medical-treatment-with-tamsulosin-a-prospective-open-label-pilot-study
#15
S Masciovecchio, A B Di Pasquale, G Ranieri, G Romano, L Di Clemente
OBJECTIVE: Lower urinary tract symptoms (LUTS) are frequently experienced in association with benign prostatic enlargement (BPE). Current guidelines state that alpha-blockers should be considered the first-line therapy of LUTS associated with BPE in most patients. However, in clinical practice treatment efficacy differs among individuals and, therefore, intra-class switch from one alpha-blocker to another, is frequently applied. In particular, switching to silodosin in clinical practice appears an intriguing therapeutic strategy due to the peculiar pharmacological properties of this molecule...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29161773/silodosin-for-the-treatment-of-lower-urinary-tract-symptoms-in-men-with-benign-prostatic-hyperplasia
#16
REVIEW
Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, Philipp Dahm
BACKGROUND: A variety of alpha-blockers are used for treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Silodosin is a novel, more selective alpha-blocker, which is specific to the lower urinary tract and may have fewer side effects than other alpha-blockers. OBJECTIVES: To assess the effects of silodosin for the treatment of LUTS in men with BPH. SEARCH METHODS: We performed a comprehensive search using multiple databases (Cochrane Library, MEDLINE, EMBASE, Scopus, Google Scholar, and Web of Science), trials registries, other sources of grey literature, and conference proceedings with no restrictions on the language of publication or publication status up until 13 June 2017...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29151116/do-alpha-1-antagonist-medications-affect-the-success-of-semi-rigid-ureteroscopy-a-prospective-randomised-single-blind-multicentric-study
#17
Mustafa Aydın, Muhammet Fatih Kılınç, Abdulmecit Yavuz, Göksel Bayar
The objective of this study is to assess the efficacy of adjunctive silodosin therapy in improving the success rate of semi-rigid ureteroscopy for removing ureteral stones. Prospective randomised controlled clinical trial performed between July 2016 and September 2016. All the patients underwent ureteroscopic holmium lithotripsy with a YAG laser. The patients were randomised into one of three groups: those who did not use an alpha-1 blocker (AB) (Group 1, n = 50), those who used an AB for one day (Group 2, n = 50), and those who used an AB for three days (Group 3, n = 47)...
November 18, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29144913/re-silodosin-versus-naftopidil-in-the-treatment-of-premature-ejaculation-a%C3%A2-prospective-multicenter-trial
#18
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29139242/-the-effiectiveness-of-extracorporeal-shock-wave-lithotripsy-in-treating-proxima-ureteral-stones
#19
M I Kogan, I I Belousov, A M Yassine
Extracorporeal shock wave lithotripsy (ESWL) has proven efficacy in the treatment of proximal ureteral stones. The research to date has not been able to establish real time to spontaneous stone clearance after ESWL and the appropriateness and effectiveness of -blockers in stimulating residual stone clearance after ESWL. AIM: To conduct a comprehensive assessment of the effectiveness of ESWL in treating proximal ureteral stones and determine the appropriateness of using -blockers to stimulate residual stone clearance...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29123161/clinically-meaningful-improvements-in-luts-bph-severity-in-men-treated-with-silodosin-plus-hexanic-extract-of-serenoa-repens-or-silodosin-alone
#20
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Walter Cazzaniga, Filippo Pederzoli, Donatella Moretti, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
To assess the rate and predictors of clinically meaningful improvements (CMI) in patients with lower urinary tract symptoms (LUTS) treated with either silodosin (SIL) alone or with a combination of SIL+ serenoa repens (Ser) hexanic lipidosterolic extract for ≥12 months. Data from 186 patients were collected. Patients completed the International Prostatic Symptoms Score (IPSS) at baseline and at follow-up assessment. Descriptive statistics and logistic regression models tested rates and predictors of CMI. Two CMI were assessed: 1) >3 points improvement in total IPSS from baseline to end (CMI#1); 2) >25% IPSS improvement from baseline to end (CMI#2)...
November 9, 2017: Scientific Reports
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