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https://www.readbyqxmd.com/read/29774170/liquid-biopsy-of-vitreous-reveals-an-abundant-vesicle-population-consistent-with-the-size-and-morphology-of-exosomes
#1
Yuanjun Zhao, Sarah R Weber, Joshua Lease, Mariano Russo, Christopher A Siedlecki, Li-Chong Xu, Han Chen, Weiwei Wang, Michael Ford, Rafael Simó, Jeffrey M Sundstrom
Purpose: To investigate the molecular components of the vitreous in order to better understand retinal physiology and disease. Methods: Vitreous was acquired from patients undergoing vitrectomy for macular hole and/or epiretinal membrane, postmortem donors, and C57BL/6J mice. Unbiased proteomic analysis was performed via electrospray ionization tandem mass spectrometry (MS/MS). Gene ontology analysis was performed and results were confirmed with transmission electron microscopy, atomic force microscopy, and nanoparticle tracking analysis (NTA)...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29772043/foveal-avascular-zone-area-analysis-in-macular-hole-before-and-after-surgery-using-optical-coherence-tomography-angiography
#2
Ferdiriva Hamzah, Ari Shinojima, Hiroyuki Nakashizuka, Akiyo Kawamorita, Hiroyuki Shimada
BACKGROUND AND OBJECTIVE: To analyze the foveal avascular zone (FAZ) area in superficial and deep retinal layers in patients with macular hole (MH) before and after surgery. PATIENTS AND METHODS: The authors studied 14 patients with unilateral MH. They examined a 3 mm × 3 mm area at the fovea before and 6 months after surgery using spectral-domain optical coherence tomography angiography. RESULTS: In eyes affected by MH, the mean preoperative superficial FAZ (0...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29760571/multiple-extrafoveal-macular-holes-following-internal-limiting-membrane-peeling
#3
Nazimul Hussain, Sandip Mitra
Objective: Internal limiting membrane (ILM) peeling has been the standard of treatment for macular holes. Besides, causing retinal nerve fiber layer surface abnormality, postoperative extrafoveal multiple retinal holes is a rare phenomenon following ILM peeling. We report an unusual complication of eight extrafoveal macular holes occurring following ILM peeling. Case presentation: A 60-year-old male presented with complaints of decreased and distorted vision in the right eye...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29758035/changes-in-macular-pigment-optical-density-after-membrane-peeling
#4
Mario R Romano, Gilda Cennamo, Piergiacomo Grassi, Federica Sparnelli, Davide Allegrini, Giovanni Cennamo
INTRODUCTION: To highlight the differences in macular pigment optical density (MPOD) between eyes with vitreoretinal interface syndrome and healthy control eyes, to assess the changes in MPOD in eyes treated with macular peeling, to investigate the relationships between MPOD changes and measures of retinal sensitivity such as best corrected visual acuity (BCVA) and microperimetry. METHODS: In this cross-sectional comparative study, 30 eyes affected by idiopathic epiretinal membrane (iERM, 15eyes) or full-thickness macular hole (FTMH, 15eyes) were compared with 60 eyes from 30 healthy age-matched patients...
2018: PloS One
https://www.readbyqxmd.com/read/29757814/macular-hole-formation-followed-by-spontaneous-closure-after-pneumatic-retinopexy-in-a-patient-with-diabetic-macular-edema
#5
Michael N Cohen, Caroline R Baumal
PURPOSE: To report early formation and spontaneous closure of a full-thickness macular hole that developed after successful pneumatic retinopexy in a patient who had been undergoing treatment for diabetic macular edema. METHODS: Case report of a 68-year-old man with bilateral nonproliferative diabetic retinopathy who was currently undergoing anti-vascular endothelial growth factor treatment for bilateral diabetic macular edema. RESULTS: On presentation, visual acuity was 20/200 in the left eye, and examination revealed a bullous, macula-off retinal detachment with a single horseshoe tear at 12 o'clock in the left eye...
May 10, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29755825/bilateral-asymmetric-rhegmatogenous-retinal-detachment-in-a-patient-with-stickler-syndrome
#6
Caner Öztürk, Almila Sarıgül Sezenöz, Gürsel Yılmaz, İmren Akkoyun
Here we present the long-term anatomical and visual outcomes of bilateral asymmetric rhegmatogenous retinal detachment repair in a patient with Stickler syndrome. A 17-year-old girl presented with decreased visual acuity in both eyes for more than one year. Her best-corrected visual acuity (BCVA) was 0.1 in the right eye and 0.05 in the left eye. Slit-lamp anterior segment examination revealed subcapsular cataract in both eyes. Fundus examination showed bilateral rhegmatogenous retinal detachment, chronic retinal detachment accompanied by multiple retinal holes, tears and membranous fibrillary vitreous in the peripheral retina...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29752946/effect-of-free-amino-acids-on-bovine-retinal-pericytes
#7
S Vidhya, R Ramya, K Coral, K N Sulochana, S R Bharathidevi
AIM: This study was conducted to estimate the aminoacid levels in the vitreous of patients with proliferative diabetic retinopathy, and to correlate it with the adiponectin levels. Secondly to test if these amino acids can alter or induce adiponectin levels and its related factors in retinal cells like pericyte as an in vitro model. METHODS: All human studies were done as per declaration of Helsinki with institutional approval and after obtaining consent from participating individuals...
May 9, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29748866/two-cases-of-repeating-recurrences-and-spontaneous-closures-of-macular-holes-in-vitrectomized-eyes
#8
Takamasa Mori, Seiji Kitamura, Hirokazu Sakaguchi, Kohji Nishida, Masahito Ohji
BACKGROUND: Three eyes of 2 cases had repeating recurrences and spontaneous closures of macular holes (MHs) after vitrectomy. CASES: A 66-year-old man had rhegmatogenous retinal detachment (RRD) in his left eye and underwent vitrectomy with successful retinal reattachment. A full-thickness MH developed 1 year after the vitrectomy and spontaneously closed 1 month later. Opening and spontaneous closure of the MH recurred an additional 4 times over 7 years. An 80-year-old man had suffered intraocular lens (IOL) dislocation and underwent vitrectomy in his left eye...
May 10, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746407/swept-source-optical-coherence-tomography-angiography-reveals-internal-limiting-membrane-peeling-alters-deep-retinal-vasculature
#9
Zofia Michalewska, Jerzy Nawrocki
PURPOSE: To describe morphology of retinal and choroidal vessels in swept-source optical coherence tomography angiography before and after vitrectomy with the temporal inverted internal limiting membrane (ILM) flap technique for full-thickness macular holes. METHODS: Prospective, observational study of 36 eyes of 33 patients with full-thickness macular holes swept-source optical coherence tomography angiography was performed in patients before and 1 month after vitrectomy...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29746406/hemi-temporal-internal-limiting-membrane-peeling-is-as-effective-and-safe-as-conventional-full-peeling-for-macular-hole-surgery
#10
Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi
PURPOSE: To investigate the efficacy of hemi-temporal internal limiting membrane (ILM) peeling for idiopathic macular hole. METHODS: The medical records of patients with macular holes who had undergone vitrectomy with ILM peeling were studied. Forty-two eyes with macular hole were divided into 2 groups based on surgical procedure (hemi-temporal ILM peeling [hemi group]: 15 eyes; 360° ILM peeling [360° group]: 27 eyes). The closure rates and distances between the optic disc and the intersection of two retinal vessels most closely located nasally or temporally to the macular hole were compared...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29744761/microstructural-retinal-regeneration-after-internal-limiting-membrane-flap-surgery-for-repair-of-large-macular-holes-a-1-year-follow-up-study
#11
Max Vieregge, Christophe Valmaggia, Hendrik P N Scholl, Josef Guber
PURPOSE: To evaluate long-term change in functional and structural outcomes after successful repair of large macular holes (MH) with internal limiting membrane (ILM) flap techniques. METHODS: Eleven consecutive patients were reviewed over a 1-year time period after the successful repair of large MH with ILM flap techniques. SD-optical coherence tomography (SD-OCT) images were taken to assess the anatomical outcome after surgery, while the best-corrected visual acuity (BCVA) was tested using Snellen charts to evaluate the functional outcome...
May 9, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29713817/23g-pars-plana-vitrectomy-for-vitreal-floaters-prospective-assessment-of-subjective-self-reported-visual-impairment-and-surgery-related-risks-during-the-course-of-treatment
#12
Ursula Hahn, Frank Krummenauer, Klaus Ludwig
PURPOSE: Quantifying the subjective impairment due to floaters based on an indication-specific questionnaire and setting its change between prior to and 3/12 months after elective vitrectomy in relation to surgical risks. METHODS: Single-arm longitudinal observational multicenter study. Sixty-four floater patients underwent 23G pars plana vitrectomy; simultaneous phacoemulsification was excluded. An overall self-rated impairment index (SRI) and sub-indices SRI were calculated on the basis of a modified Visual Quality of Life questionnaire (VQoL), which addresses general vision, glare, near-sight problems and mobility of floaters...
April 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29706600/retrospective-cohort-study-exploring-whether-an-association-exists-between-spatial-distribution-of-cystoid-spaces-in-cystoid-macular-oedema-secondary-to-retinitis-pigmentosa-and-response-to-treatment-with-carbonic-anhydrase-inhibitors
#13
Stacey A Strong, Nashila Hirji, Ana Quartilho, Angelos Kalitzeos, Michel Michaelides
BACKGROUND: Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29702978/optic-neuropathy-causing-vertical-unilateral-hemianopsia-after-pars-plana-vitrectomy-for-a-macular-hole-a-case-report
#14
Hirohiko Kawashima, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
INTRODUCTION: Recent progress in medical technology has resulted in improved surgical outcomes of pars plana vitrectomy (PPV); with microincision systems, the incidence of procedure-related complications during surgery has been reduced. However, unpredictable visual field defects after PPV remain an unresolved issue. A few reports have shown that damage to the retinal neurofibers owing to dry-up during air/fluid exchange or retinal neurotoxicity of the dye used to visualize the internal limiting membrane (ILM), as well as unintentional removal of retinal neurofibers during ILM peeling, are responsible for such visual field disorders...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29676326/macular-hole-associated-retinal-detachment-in-best-vitelliform-dystrophy-series-of-two-cases-and-literature-review
#15
Ruchir Tewari, Vinod Kumar, Raghav Ravani, Devashish Dubey, Parijat Chandra, Atul Kumar
Two eyes of 2 patients with macular hole-associated retinal detachment in clinically diagnosed vitelliruptive stage of Best vitelliform dystrophy were surgically managed by 25-gauge sutureless pars plana vitrectomy, internal limiting membrane (ILM) peeling with inverted ILM flap, and short-acting (SF6 ) gas tamponade. The patients were assessed with respect to best-corrected visual acuity, color fundus photographs, shortwave fundus autofluorescence, and swept source optical coherence tomography. Surgical intervention led to Type 1 closure of macular hole, resolution of retinal detachment, and improvement in vision in both patients...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676315/vitreoretinal-surgery-on-the-fellow-eye-a-retrospective-analysis-of-18-years-of-surgical-data-from-a-tertiary-center-in-england
#16
Mark A P Fajgenbaum, Roger S Wong, David A H Laidlaw, Tom H Williamson
Purpose: To determine the long-term incidence of fellow-eye surgical involvement in patients who have undergone first-eye vitreoretinal (VR) surgery for a variety of indications. This was a single-institution retrospective, consecutive series. Methods: Eighteen years of electronic surgical data were reviewed at our institution. All patients having surgery for the following indications were included: rhegmatogenous retinal detachment (RRD), macular hole (MH), epiretinal membrane (ERM), proliferative diabetic retinopathy (PDR), vitritis, and dropped nucleus...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29643791/autologous-transplantation-of-the-internal-limiting-membrane-for-refractory-macular-hole-following-ruptured-retinal-arterial-macroaneurysm-a-case-report
#17
Yumi Iwakawa, Hisanori Imai, Hiromi Kaji, Yuki Mori, Chihiro Ono, Keiko Otsuka, Akiko Miki, Mariko Oishi
Purpose: To report a case of macular hole (MH) secondary to a retinal arterial macroaneurysm (RAMA) which was successfully treated with an autologous transplantation of internal limiting membrane (ILM). Case Report: An 87-year-old female presented with a sudden decrease in central vision in the right eye. A fundus examination revealed a RAMA in the superonasal macular region, a subretinal hemorrhage (SRH), involving the macula, and a sub-ILM hemorrhage. A pars plana vitrectomy (PPV) was performed...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29629640/full-thickness-macular-hole-without-necrosis-in-a-case-of-viral-retinitis
#18
Sangeeta Roy, Brijesh Takkar, Priyanka Khandelwal, Rohan Chawla
No abstract text is available yet for this article.
January 1, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29623721/evaluation-of-ocular-perforation-during-retrobulbar-block-using-high-resolution-spectral-domain-optical-coherence-tomography-and-optical-coherence-tomography-angiography
#19
Stanislao Rizzo, Ruggero Tartaro, Lucia Finocchio, Andrea Giorni, Daniela Bacherini, Alfonso Savastano
INTRODUCTION: This article reports a case of ocular perforation during a retrobulbar block in a patient who underwent scleral buckle for retinal detachment. METHODS: Sterile air was immediately injected into the vitreous cavity to restore intraocular pressure and the scleral buckle operation was quickly finished. One week later, a laser retinopexy was performed on the two retinal holes that were outside the foveal area. After 6 months, spectral domain-optical coherence tomography and optical coherence tomography angiography were performed on the perforated wall centered on the exit hole area...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29623462/long-term-follow-up-of-lamellar-macular-holes-and-pseudoholes-over-at-least-5-years
#20
K Purtskhvanidze, L Balken, T Hamann, L Wöster, C von der Burchard, J Roider, Felix Treumer
PURPOSE: To assess morphological and functional changes of lamellar macular holes and pseudoholes with or without vitrectomy and membrane peeling with at least 5 years follow-up. METHODS: Retrospective study of 73 eyes with lamellar macular hole (LH, n = 28), macular pseudohole (PH, n = 31), and pseudohole with cleaved edges (cleavedPH, n = 14). Forty-six eyes were merely observed without vitreoretinal intervention (observation group), and 27 eyes underwent vitrectomy with membrane peeling (vitrectomy group)...
April 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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