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Non-small cell Lung cancer mediastinal staging

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https://www.readbyqxmd.com/read/27912764/sbrt-for-centrally-localized-nsclc-what-is-too-central
#1
J Roesch, C Panje, F Sterzing, F Mantel, U Nestle, N Andratschke, M Guckenberger
PURPOSE: Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of peripheral lung tumors. However, the discussion on SBRT for centrally located tumors is controversial. This study evaluated current clinical practice regarding SBRT of centrally located lung tumors, to identify common fractionation schedules and commonly accepted contraindications for SBRT...
December 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27884195/lymph-node-ratio-as-a-prognostic-factor-in-patients-with-pathological-n2-non-small-cell-lung-cancer
#2
Masaya Tamura, Isao Matsumoto, Daisuke Saito, Shuhei Yoshida, Munehisa Takata, Hirofumi Takemura
BACKGROUND: The aim of this study was to investigate whether the lymph node ratio (LNR) was associated with the prognosis of patients, who underwent surgery for pathological N2 non-small cell lung cancer (NSCLC). METHODS: A total of 182 patients were diagnosed with pathological N2 disease and underwent complete resection surgeries with systematic lymphadenectomies. We counted the number of positives and removed lymph nodes to calculate a ratio between them (LNR)...
November 25, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27870565/concurrent-chemotherapy-and-radiation-therapy-for-inoperable-locally-advanced-non-small-cell-lung-cancer
#3
Kenneth E Rosenzweig, Jorge E Gomez
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27866516/-gsi-quantitative-parameters-preoperative-diagnosis-of-metastasis-lymph-nodes-in-lung-cancer
#4
Fengfeng Yang, Jie Dong, Xiaolong Yan, Xiuting Wang, Xiaojiao Fu, Tong Zhang
BACKGROUND: Mediastinal involvement in lung cancer is an important prognostic factor affecting survival, and accurate staging of the mediastinum lymph node correctly identifies patients who can benefit the most from surgery. The aim of this study is to investigate the value of dual-energy spectral computed tomography (DEsCT) imaging in differentiating metastatic from non-metastatic lymph nodes in lung cancer. METHODS: Forty-eight patients with non-small cell lung cancer (NSCLC) underwent arterial (AP) and portal venous (PP) phase contrast-enhanced DEsCT imaging followed by surgical treatment...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27826571/lymph-node-dissection-after-pulmonary-resection-for-lung-cancer-a-mini-review
#5
REVIEW
Stylianos Korasidis, Cecilia Menna, Claudio Andreetti, Giulio Maurizi, Antonio D'Andrilli, Anna Maria Ciccone, Francesco Cassiano, Erino Angelo Rendina, Mohsen Ibrahim
An accurate staging of a malignant disease is imperative in order to plan pre- and post-operative therapy, define prognosis and compare studies. According to the European Society of Thoracic Surgeons (ESTS) guidelines a systematic lymph node (LN) dissection is recommended in all cases of pulmonary resection for non-small cell lung cancer (NSCLC). The current lung cancer staging system considers the lymphatic stations involved but not the number of LNs. Up to date, published scientific studies on hilar and mediastinal lymphadenectomy mainly have been regarded the type of LN dissection procedure after pulmonary resection (selected LN biopsy, LN sampling, systematic nodal dissection, lobe specific nodal dissection and extended LN dissection) focusing particularly on the comparison between mediastinal LN dissection (MLND) and mediastinal LN sampling (MLNS)...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27794400/pre-and-postoperative-care-for-stage-i-iii-nsclc-which-quality-of-care-indicators-are-evidence-based
#6
REVIEW
Rachel C Numan, Martijn Ten Berge, Jacobus A Burgers, Houke M Klomp, Johanna W van Sandick, Paul Baas, Michel W Wouters
Identification of evidenced-based Quality of Care (QoC) indicators for lung cancer care is essential to quality improvement. The aim of this review was to identify evidence-based quality indicators for the pre- and postoperative care of stage I-III Non Small Cell Lung Cancer (NSCLC) provided by the lung physician. To obtain these indicators, a search in PubMed, Embase and the Cochrane library database was performed. English literature published between 1980 and 2012 was included and search terms regarding 'lung neoplasms', 'quality of care', 'pathology', 'diagnostic methods', 'preoperative and postoperative treatment' were used...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27788387/postoperative-radiotherapy-for-lung-cancer-is-it-worth-the-controversy
#7
REVIEW
Charlotte Billiet, Stéphanie Peeters, Herbert Decaluwé, Johan Vansteenkiste, Jeroen Mebis, Dirk De Ruysscher
INTRODUCTION: The role of postoperative radiation therapy (PORT) in patients with completely resected non-small cell lung cancer (NSCLC) with pathologically involved mediastinal lymph nodes (N2) remains unclear. Despite a reduction of local recurrence (LR), its effect on overall survival (OS) remains unproven. Therefore we conducted a review of the current literature. METHODS: To investigate the benefit and safety of modern PORT, we identified published phase III trials for PORT...
December 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27785064/the-influence-of-the-metastasis-pattern-of-mediastinal-lymph-nodes-on-the-postoperative-radiotherapy-s-efficacy-for-the-iiia-pn2-non-small-cell-lung-cancer-a-retrospective-analysis-of-220-patients
#8
Baozhong Zhang, Lujun Zhao, Zhiyong Yuan, Qingsong Pang, Ping Wang
OBJECTIVE: The use of postoperative radiotherapy (PORT) remains controversial for Stage IIIA-N2 non-small-cell lung cancer (NSCLC) patients, a possible reason is that IIIA-pN2 NSCLC diseases are a heterogeneous group with different clinicopathologic features. The aim of this research was to prove whether the mediastinal lymph nodes' (LNs) skipping status could indicate the necessity of the PORT for the pN2 NSCLC patients. METHODS: The skip metastasis was defined as pN0N2 (no N1 LN involved), and nonskip metastasis was pN1N2 (one or more N1 LNs involved)...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27773666/added-value-of-combined-endobronchial-and-oesophageal-endosonography-for-mediastinal-nodal-staging-in-lung-cancer-a-systematic-review-and-meta-analysis
#9
Daniël A Korevaar, Laurence M Crombag, Jérémie F Cohen, René Spijker, Patrick M Bossuyt, Jouke T Annema
BACKGROUND: Guidelines recommend endosonography with fine-needle aspiration for mediastinal nodal staging in non-small-cell lung cancer, but most do not specify whether this should be through endobronchial endoscopy (EBUS), oesophageal endoscopy (EUS), or both. We assessed the added value and diagnostic accuracy of the combined use of EBUS and EUS. METHODS: For this systematic review and random effects meta-analysis, we searched MEDLINE, Embase, BIOSIS Previews, and Web of Science, without language restrictions, for studies published between Jan 1, 2000, and Feb 25, 2016...
October 20, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27765813/limited-resection-for-early-stage-non-small-cell-lung-cancer-as-function-preserving-radical-surgery-a-review
#10
Keiju Aokage, Junji Yoshida, Tomoyuki Hishida, Masahiro Tsuboi, Hisashi Saji, Morihito Okada, Kenji Suzuki, Syunichi Watanabe, Hisao Asamura
Since 'radical lobectomy' was reported by Cahan in 1960, the standard surgical care for lung cancer has been lobectomy, in which units of the lobe are excised with their specific regional hilar and mediastinal lymphatics. However, pulmonary function-preserving limited resection for lung cancer has gradually become more prevalent in the late 20th century. In 1995, Ginsberg et al. conducted a randomized controlled trial in which limited resection (segmentectomy and wide-wedge resection) and lobectomy for stage I lung cancer were compared and reported that limited resection should not be applied to healthy patients with clinical stage IA lung cancer...
October 20, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27746997/efficacy-of-lymph-node-dissection-during-robotic-assisted-lobectomy-for-non-small-cell-lung-cancer-retrospective-review-of-159-consecutive-cases
#11
Frank O Velez-Cubian, Kathryn L Rodriguez, Matthew R Thau, Carla C Moodie, Joseph R Garrett, Jacques P Fontaine, Eric M Toloza
BACKGROUND: We investigated whether robotic-assisted surgery improves mediastinal lymph node dissection (MLND). METHODS: We analyzed patients (pts) who underwent robotic-assisted video-assisted thoracoscopic surgery (R-VATS) lobectomy for non-small cell lung cancer (NSCLC) over 36 months. Perioperative outcomes, tumor histology, numbers, locations, and status of all lymph nodes (LNs), and TNM (tumor, nodal, and metastasis) stage changes were analyzed. RESULTS: One hundred fifty-nine pts had mean tumor size 3...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27716240/salvage-surgery-for-local-failures-after-stereotactic-ablative-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#12
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27710975/a-multicenter-feasibility-study-of-ebus-tbna-for-potentially-operable-non-small-cell-lung-cancer-the-jmto-lc07-02-study-umin000001280
#13
Fumihiro Tanaka, Seiki Hasegawa, Nobuyuki Kondo, Ryo Miyahara, Hiroshi Date, Shinji Atagi, Masaaki Kawahara, Takeharu Yamanaka, Toshiaki Manabe, Hiromi Wada
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure for the pathological evaluation of the mediastinal nodal (N2) status of lung cancer; however, its feasibility in potentially operable patients with suspicion of minimal N2 disease remains unestablished. PATIENTS AND METHODS: A prospective multicenter study was conducted to assess the feasibility of EBUS-TBNA in this setting. Patients with clinical stage IIIA-N2 non-small cell lung cancer (NSCLC) and mediastinal nodal enlargement on computed tomography (CT) were eligible; patients were ineligible when CT revealed bulky (> 3 cm in the long-axis diameter) N2 or multiple (≥ 3) station N2...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27677242/neoadjuvant-chemoradiotherapy-vesus-chemotherapy-alone-followed-by-surgery-for-resectable-stage-iii-non-small-cell-lung-cancer-a-meta-analysis
#14
Shan Xian Guo, Yan Jian, Ying Lan Chen, Yun Cai, Qing Yuan Zhang, Fang Fang Tou
Neoadjuvant Chemotherapy has been used for the stage III of non-small cell lung cancer (NSCLC) and has shown good clinical effects. However, the survival benefits of radiation therapy added in induction regimens remains controversial. We therefore conducted a meta-analysis of the published clinical trials to quantitatively evaluate the benefit of preoperative chemoradiotherapy. After searching the database of Pubmed, CNKI, EMBASE, ESMO, The Cochrane Library databases, The American Society of Clinical Oncology and Clinical Trials...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27675547/indications-for-invasive-mediastinal-staging-in-patients-with-early-non-small-cell-lung-cancer-staged-with-positron-emission-tomography-computed-tomography
#15
S Gao, A W Kim, F C Detterbeck, D Boffa, J Puchalski, R H Decker
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674777/timing-of-surgery-after-neoadjuvant-chemoradiation-in-clinical-stage-iiia-non-small-cell-lung-cancer-with-mediastinal-nodal-involvement
#16
S Gao, C D Corso, E H Wang, J Blasberg, D Boffa, F C Detterbeck, A W Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674729/mediastinal-lymph-node-volume-is-associated-with-locoregional-recurrence-and-overall-survival-in-stage-iiia-iiib-non-small-cell-lung-cancer
#17
V Agrawal, T P Coroller, Y Hou, S Lee, J Romano, E H Baldini, A B Chen, D E Kozono, S J Swanson, J Wee, H Aerts, R H Mak
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27665362/upstaging-and-survival-after-robotic-assisted-thoracoscopic-lobectomy-for-non-small-cell-lung-cancer
#18
Kavian Toosi, Frank O Velez-Cubian, Jessica Glover, Emily P Ng, Carla C Moodie, Joseph R Garrett, Jacques P Fontaine, Eric M Toloza
BACKGROUND: Mediastinal involvement in resected non-small-cell lung cancer mandates adjuvant therapy and affects survival. This study investigated lymph node dissection efficacy, lymph node metastasis detection, and survival after robotic-assisted lobectomy for non-small-cell lung cancer. METHODS: We retrospectively analyzed patients who underwent robotic-assisted lobectomy for non-small-cell lung cancer. Survival was assessed through chart reviews, Social Security Death Registry, and national obituary searches...
September 21, 2016: Surgery
https://www.readbyqxmd.com/read/27637288/endosonography-versus-mediastinoscopy-in-mediastinal-staging-of-lung-cancer-systematic-review-and-meta-analysis
#19
Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh Nath Aggarwal, Digambar Behera, Ritesh Agarwal
Whether endosonography can replace mediastinoscopy as the initial procedure for mediastinal staging of non-small cell lung cancer remains controversial. Herein, we perform a systematic review of randomized controlled trials and observational studies (both procedures performed in same subjects) comparing the two procedures. Nine studies (960 subjects) were identified. The pooled risk-difference of the sensitivity of endosonography versus mediastinoscopy in observational studies and randomized controlled trials was 0...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27623273/clinical-predictors-of-persistent-mediastinal-nodal-disease-after-induction-therapy-for-stage-iiia-n2-non-small-cell-lung-cancer
#20
Mohamed K Kamel, Mohamed Rahouma, Galal Ghaly, Abu Nasar, Jeffrey L Port, Brendon M Stiles, Andrew B Nguyen, Nasser K Altorki, Paul C Lee
BACKGROUND: Patients with persistent N2 disease after induction have poor survival. Many of these patients may have had mediastinoscopy before induction therapy, making reassessment of the mediastinum by repeat mediastinoscopy hazardous and inaccurate. The sensitivity and specificity of endobronchial ultrasonography and nodal fine-needle aspiration in this setting is unclear. In this study, we sought to identify the clinical predictors of persistent N2 disease after induction therapy, which may help in selecting the patients most likely to benefit from surgical resection...
September 9, 2016: Annals of Thoracic Surgery
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