Tiemo S Gerber, Dirk A Ridder, Benjamin Goeppert, Alexander Brobeil, Philipp Stenzel, Stefanie Zimmer, Jörg Jäkel, Marie Oliver Metzig, Roxana Schwab, Steve Z Martin, András Kiss, Frank Bergmann, Peter Schirmacher, Peter R Galle, Hauke Lang, Wilfried Roth, Beate K Straub
Distinguishing primary liver cancer (PLC), namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), from liver metastases is of crucial clinical importance. Histopathology remains the gold standard, but differential diagnosis may be challenging. While absent in most epithelial, the expression of the adherens junction glycoprotein N-cadherin is commonly restricted to neural and mesenchymal cells, or carcinoma cells that undergo the phenomenon of epithelial-to-mesenchymal transition (EMT)...
January 11, 2024: International Journal of Cancer. Journal International du Cancer