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https://www.readbyqxmd.com/read/28817342/hypoglycemia-risk-related-to-double-dose-is-markedly-reduced-with-basal-insulin-peglispro-versus-insulin-glargine-in-patients-with-type-2-diabetes-mellitus-in-a-randomized-trial-imagine-8
#1
Cynthia Harris, Thomas Forst, Tim Heise, Leona Plum-Mörschel, Elaine Watkins, Qianyi Zhang, Ludi Fan, Parag Garhyan, Niels Porksen
BACKGROUND: Basal insulin peglispro (BIL) has a peripheral-to-hepatic distribution of action that resembles endogenous insulin and a prolonged duration of action with a flat pharmacokinetic/pharmacodynamic profile at steady state, characteristics that tend to reduce hypoglycemia risk compared to insulin glargine (GL). The primary objective was to demonstrate that clinically significant hypoglycemia (blood glucose ≤54 mg/dL [3.0 mmol/L] or symptoms of severe hypoglycemia) occurred less frequently within 84 h after a double dose (DD) of BIL than a DD of GL...
August 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28815714/william-hazlitt-obsessive-love-and-liber-amoris
#2
Harry Trosman
William Hazlitt, a distinguished literary figure of the early nineteenth century and a forerunner of psychoanalytic insights, had a keen awareness of the impact of the imagination on assessing works of art. At forty-two, he became hopelessly involved in an obsessive love affair with a nineteen-year-old woman and could not extricate himself from the relationship. The affair followed the death of his father, a powerful influence on his life. Factors in his obsessive love included finding an object of idealization subject to his imaginative creation and narcissistically reexperiencing himself about to begin a new life...
July 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28815502/flping-genes-on-and-off-in-drosophila
#3
Bonnie M Weasner, Jinjin Zhu, Justin P Kumar
The fruit fly, Drosophila melanogaster, has been a favorite experimental system of developmental biologists for more than a century. One of the most attractive features of this model system is the clarity by which one can analyze mutant phenotypes. Most genes are found in single copies, and loss-of-function mutants often have obvious phenotypes that can be analyzed during development and in adulthood. As with all metazoans, a significant fraction of Drosophila genes are used during both embryonic and postembryonic development, and null mutants often die during embryogenesis thereby precluding the analysis of postembryonic tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28812849/global-health-in-the-anthropocene-moving-beyond-resilience-and-capitalism-comment-on-health-promotion-in-an-age-of-normative-equity-and-rampant-inequality
#4
Remco van de Pas
There has been much reflection on the need for a new understanding of global health and the urgency of a paradigm shift to address global health issues. A crucial question is whether this is still possible in current modes of global governance based on capitalist values. Four reflections are provided. (1) Ecological -centered values must become central in any future global health framework. (2) The objectives of 'sustainability' and 'economic growth' present a profound contradiction. (3) The resilience discourse maintains a gridlock in the functioning of the global health system...
December 24, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28811142/anatomical-analysis-of-human-ligamentum-flavum-in-the-cervical-spine-special-consideration-to-the-attachments-coverage-and-lateral-extent
#5
Mohammad Suhrab Rahmani, Hidetomi Terai, Javid Akhgar, Akinobu Suzuki, Hiromitsu Toyoda, Masatoshi Hoshino, Koji Tamai, Sayed Abdullah Ahmadi, Kazunori Hayashi, Shinji Takahashi, Hiroaki Nakamura
BACKGROUND: Posterior decompression surgeries of cervical spine such as laminoplasty and laminoforaminotomy are well established and increasing in aging population. The anatomical knowledge of cervical ligamentum flavum (LF) is critical to perform posterior spinal surgeries, however, few studies have evaluated it, especially the relation of LF and neural foramen. METHODS: The whole spine was removed en bloc from 15 formalin-embalmed human cadavers and then divided into two segments along the pedicle bases...
August 12, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28810328/-clinical-features-of-11-cases-of-primary-bone-lymphoma
#6
Y J Li, Y F Li, J W Du, L H Dong, X Gao, G P Li, X D Wei, Y P Song
Objective: To analyze the clinical features, treatment and outcomes of primary lymphoma of bone (PLB) . Methods: The clinical data of 11 PLB patients were retrospectively analyzed. Results: 11 patients were enrolled in our study including 7 females and 4 males. The median age of the patients was 45 years old. The main histologic type was diffuse large B cell lymphoma and anaplastic large cell lymphoma. Of the 11 PLB cases, 3 cases were at stage ⅠE, 2 at stage ⅡE, 6 at stage ⅣE respectively. 6 cases were treated with chemotherapy and radiotherapy, 2 cases with total joint arthroplasty and chemotherapy, and 3 cases chemotherapy alone respectively...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28810273/-nursing-internship-internal-medicine-evaluation-and-influences-on-the-attitude-towards-the-specialization
#7
Janine Wirkner, Sylvia Stracke, Anja Lange, Thomas Dabers, Harry Merk, Richard Kasch
Background German medical students have to perform a nursery internship of three month duration. While this internship is widely discussed, there is a lack of student evaluation data. Objectives Here, for the first time, student evaluation of a nursery internship in internal medicine (IM) is investigated. Moreover, the question was raised, whether the early experience during this internship may influence students' attitude towards the specialty. Methods In a nation-wide online-survey, 767 German medical students (mean age 22...
August 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28809822/assessment-and-communication-for-people-with-disorders-of-consciousness
#8
Rupert Ortner, Brendan Z Allison, Gerald Pichler, Alexander Heilinger, Nikolaus Sabathiel, Christoph Guger
In this experiment, we demonstrate a suite of hybrid Brain-Computer Interface (BCI)-based paradigms that are designed for two applications: assessing the level of consciousness of people unable to provide motor response and, in a second stage, establishing a communication channel for these people that enables them to answer questions with either 'yes' or 'no'. The suite of paradigms is designed to test basic responses in the first step and to continue to more comprehensive tasks if the first tests are successful...
August 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28808983/ability-and-sex-differences-in-spatial-thinking-what-does-the-mental-rotation-test-really-measure
#9
Mary Hegarty
Spatial ability tests are often interpreted as measuring facility with imagined spatial transformations of objects. But some spatial ability tests can be solved by analytic strategies as well as imagery transformation strategies. In the present study, participants gave verbal protocols while completing items on the Vandenberg and Kuse (Perceptual & Motor Skills, 4, 599-604, 1978) mental rotation test, and/or reported the strategies they had used on the test. Most participants used both imagery transformation and analytic strategies (i...
August 14, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28808819/separating-the-idea-from-the-action-a-sloreta-study
#10
Martin Rakusa, Pierpaolo Busan, Piero Paolo Battaglini, Janez Zidar
Simple imaginary movements activate similar cortical and subcortical areas to actual movements, chiefly in the sensory-motor network. However, only a few studies also examined the imagery of more skilful movements such as reaching. Ten volunteers performed reaching movements or imagined the same movements. EEG was simultaneously recorded and analysed with sLORETA, which compared the preparation for actual and imagined reaching with respect to their baseline and between tasks. Major differences between them were found at three time intervals after target presentation, always in favour of the actual reaching condition...
August 14, 2017: Brain Topography
https://www.readbyqxmd.com/read/28808583/successful-spinal-cord-stimulation-for-neuropathic-below-level-spinal-cord-injury-pain-following-complete-paraplegia-a-case-report
#11
Tim A Reck, Gunther Landmann
INTRODUCTION: Neuropathic pain is common in patients with spinal cord injury (SCI) and often difficult to treat. We report a case where epidural spinal cord stimulation (SCS) below the level of injury has been successfully applied in a patient with a complete spinal cord lesion. CASE PRESENTATION: A 53-year-old female presented with neuropathic below-level SCI pain of both lower legs and feet due to complete SCI below T5. Time and pain duration since injury was 2 years...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28807441/whole-body-dose-and-energy-measurements-in-radiotherapy-by-a-combination-of-lif-mg-cu-p-and-lif-mg-ti
#12
Pascal Hauri, Uwe Schneider
PURPOSE: Long-term survivors of cancer who were treated with radiotherapy are at risk of a radiation-induced tumor. Hence, it is important to model the out-of-field dose resulting from a cancer treatment. These models have to be verified with measurements, due to the small size, the high sensitivity to ionizing radiation and the tissue-equivalent composition, LiF thermoluminescence dosimeters (TLD) are well-suited for out-of-field dose measurements. However, the photon energy variation of the stray dose leads to systematic dose errors caused by the variation in response with radiation energy of the TLDs...
August 11, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28804650/the-2d%C3%A2-%C3%A2-4d-digit-ratio-as-a-biomarker-for-autism-spectrum-disorder
#13
M Mackus, D de Kruijff, L S Otten, A D Kraneveld, J Garssen, J C Verster
It has been suggested that the second (2D, index finger) to fourth (4D, ring finger) digit ratio, 2D : 4D, may be a biomarker for the risk of developing autism. The aim of the current study was to determine the usefulness of the 2D : 4D digit ratio as biomarker for autistic traits. N = 401 healthy young volunteers participated in the study. For both hands, digit lengths were measured using digital Vernier calipers. In addition to demographics, the Autism Spectrum Quotient (AQ) questionnaire was completed, comprised of five subscales, assessing "social insights and behavior," "attention switching," "communication," "imagination," and "attention to detail...
2017: Autism Research and Treatment
https://www.readbyqxmd.com/read/28803804/effect-of-esthetic-coating-on-surface-roughness-of-orthodontic-archwires
#14
Seyed Mohammad Mousavi, Milad Shamohammadi, Zahra Rastegaar, Masoumeh Skini, Vahid Rakhshan
BACKGROUND AND AIM: Esthetic wires are commonly used in orthodontic treatments. Surface roughness is an important factor in the friction and bacterial adhesion in these wires. Surface roughness of esthetic wires has not been assessed, except in a few recent (mostly qualitative esthetics) studies. The aim of this study was to quantitatively compare the surface roughness of 4 coated esthetic wires with that of a conventional orthodontic wire. MATERIALS AND METHODS: In this in vitro trial, 25 coated and uncoated orthodontic archwires were studied, including: NiTi Memory wire (American Orthodontics, USA) as a control group; Orthocosmetic Elastinol (Ortho Organizers, USA); Perfect (Hubit, Korea); Imagination (Gestenco, Sweden); EverWhite (American Orthodontics, USA)...
August 10, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28802103/where-you-are-affects-what-you-can-easily-imagines-environmental-geometry-elicits-sensorimotor-interference-in-remote-perspective-taking
#15
Bernhard E Riecke, Timothy P McNamara
Imagined perspective switches are notoriously difficult, a fact often ascribed to sensorimotor interference between one's to-be-imagined versus actual orientation. Here, we demonstrate similar interference effects, even if participants know they are in a remote environment with unknown spatial relation to the learning environment. Participants learned 15 target objects irregularly arranged in an office from one orientation (0°, 120°, or 240°). Participants were blindfolded and disoriented before being wheeled to a test room of similar geometry (exp...
August 9, 2017: Cognition
https://www.readbyqxmd.com/read/28801245/episodic-future-thinking-and-future-based-decision-making-in-a-case-of-retrograde-amnesia
#16
Flavia De Luca, Francesca Benuzzi, Elena Bertossi, Davide Braghittoni, Giuseppe di Pellegrino, Elisa Ciaramelli
We investigated episodic future thinking (EFT) and future-based cognition and decision-making in patient SG, who developed a dense retrograde amnesia following hypoxia due to a cardiac arrest. Despite intact general cognitive and executive functioning, SG was unable to remember events from his entire lifetime. He had, however, relatively spared anterograde memory and general semantic knowledge. Voxel-based morphometry detected a reduction of gray matter in the thalamus, cerebellum and fusiform gyrus bilaterally, and, at a reduced threshold, in several regions of the autobiographical memory network, including the hippocampi...
August 9, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28797188/validation-of-psychometric-properties-and-development-of-response-criteria-for-the-psoriasis-symptoms-and-signs-diary-pssd-results-from-a-phase-iii-clinical-trial
#17
April Armstrong, Luis Puig, Richard Langley, Tsen Fang Tsai, Michael Song, Yasmine Wasfi, Jingzhi Jiang, Shu Li, Chenglong Han
PURPOSE: The Psoriasis Symptoms and Signs Diary (PSSD) is a patient-reported instrument that assesses severity of six psoriasis symptoms (itch, skin tightness, burning, stinging, and pain,) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding). MATERIALS AND METHODS: PSSD symptoms and signs summary scores (0-100) were derived based on individual item scores (0-10 [absent-worst imaginable]). Using Psoriasis Area and Severity Index [PASI], Investigator's Global Assessment [IGA] and Dermatology Life Quality Index [DLQI]) data from the NAVIGATE trial of patients with moderate-to-severe psoriasis, analyses were conducted to further validate the PSSD (7-day recall version) and establish criteria for clinically meaningful improvements (CMIs)...
August 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28797109/upper-limb-movements-can-be-decoded-from-the-time-domain-of-low-frequency-eeg
#18
Patrick Ofner, Andreas Schwarz, Joana Pereira, Gernot R Müller-Putz
How neural correlates of movements are represented in the human brain is of ongoing interest and has been researched with invasive and non-invasive methods. In this study, we analyzed the encoding of single upper limb movements in the time-domain of low-frequency electroencephalography (EEG) signals. Fifteen healthy subjects executed and imagined six different sustained upper limb movements. We classified these six movements and a rest class and obtained significant average classification accuracies of 55% (movement vs movement) and 87% (movement vs rest) for executed movements, and 27% and 73%, respectively, for imagined movements...
2017: PloS One
https://www.readbyqxmd.com/read/28796840/yes-research-matters
#19
Mari L Shinohara
My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In his case, the diagnosis started from a suggestion by his doctor to check whether he had a gastric infection with Helicobacter pylori, a bacterial species found in the digestive tract. In Japan, where he lives, a majority of gastric cancer patients (more than 99%) have been infected with H...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28795383/integrated-imaginative-distention-therapy-to-cope-with-fatigue-dimmi-si-study-the-first-randomized-controlled-trial-in-multiple-sclerosis
#20
Annalisa Sgoifo, Angelo Bignamini, Loredana La Mantia, Maria G Celani, Piero Parietti, Maria A Ceriani, Maria R Marazzi, Paola Proserpio, Lino Nobili, Alessandra Protti, Elio C Agostoni
INTRODUCTION: Fatigue is a frequent, disabling, and difficult to treat symptom in neurological disease and in other stress-related conditions; Integrated Imaginative Distention (IID) is a therapy combining muscular and imaginative relaxation, feasible also in disabled subjects; the DIMMI SI trial was planned to evaluate IID efficacy on fatigue. METHODS: The design was a parallel, randomised 1:1 (intervention:waiting list), controlled, open-label trial. Participants were persons with multiple sclerosis (pwMS), persons with insomnia (pwINS), and health professionals (HP) as conditions related to fatigue and stress...
August 9, 2017: Neurology and Therapy
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