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https://www.readbyqxmd.com/read/28991412/virtual-screening-approach-of-bacterial-peptide-deformylase-inhibitors-results-in-new-antibiotics
#1
Amina Merzoug, Abdelouahab Chikhi, Abderrahmane Bensegueni, Hanane Boucherit, Sezer Okay
The increasing resistance of bacteria to antibacterial therapy poses an enormous health problem, it renders the development of new antibacterial agents with novel mechanism of action an urgent need. Peptide deformylase, a metalloenzyme which catalytically removes N-formyl group from N-terminal methionine of newly synthesized polypeptides, is an important target in antibacterial drug discovery. In this study, we report the structure-based virtual screening of ZINC database in order to discover potential hits as bacterial peptide deformylase enzyme inhibitors with more affinity as compared to GSK1322322, previously known inhibitor...
October 9, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28982382/correction-to-functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#2
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine
No abstract text is available yet for this article.
October 5, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28948902/survey-of-owner-subcutaneous-fluid-practices-in-cats-with-chronic-kidney-disease
#3
Crystal M Cooley, Jessica M Quimby, Sarah Ma Caney, Liberty G Sieberg
Objectives The purpose of this study was to survey owners regarding their practices and experiences with the administration of subcutaneous (SC) fluids at home to cats with chronic kidney disease (CKD) to gain insight that might help more owners be successful with the procedure. Methods A web-based survey was advertised online. Owners of 468 cats with CKD participated, 399 of whom administered SC fluids. Results Fifty-nine percent of the cats were domestic shorthairs, with >85% of the cats being 10 years of age or older...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28928358/a-new-method-in-laparoscopic-sleeve-gastrectomy-reverse-trendelenburg-with-right-lateral-tilt-position-prior-to-trocar-entry
#4
Okay Koç, İbrahim Tayfun Şahiner, Feza Ekiz
BACKGROUND The primary aim of this study was to evaluate the effectiveness of patient positioning prior to trocar entry in laparoscopic sleeve gastrectomy. MATERIAL AND METHODS The records of 300 patients that had a laparoscopic sleeve gastrectomy surgery at Aydin State Hospital from January 2015 until January 2017 were analyzed retrospectively. First, 140 patients who had been placed in the surgical position after the entry of trocars (PAET) were included as the first group, and 160 patients who had been placed in the surgical position before entry of trocars (PBET) were included as the second group...
September 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28923359/difficult-choices-in-stage-i-uterine-leiomyosarcoma-it-s-okay-to-stand-there
#5
EDITORIAL
Martee L Hensley
No abstract text is available yet for this article.
October 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28870248/functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#6
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine
BACKGROUND: While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. METHODS: Patients treated for oral cancer at three institutions (University of Alberta Hospital, Mount Sinai Beth Israel Medical Center, and Turku University Hospital) were administered patient-reported outcomes assessing speech [Speech Handicap Index (SHI)], swallowing [(M...
September 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28852018/ape1-guides-dna-repair-pathway-choice-that-is-associated-with-drug-tolerance-in-glioblastoma
#7
Thomas Ströbel, Sibylle Madlener, Serkan Tuna, Sarah Vose, Tonny Lagerweij, Thomas Wurdinger, Klemens Vierlinger, Adelheid Wöhrer, Brendan D Price, Bruce Demple, Okay Saydam, Nurten Saydam
Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key factor in base-excision repair of DNA. High expression or aberrant subcellular distribution of Ape1 has been detected in many cancer types, correlated with drug response, tumor prognosis, or patient survival. Here we present evidence that Ape1 facilitates BRCA1-mediated homologous recombination repair (HR), while counteracting error-prone non-homologous end joining of DNA double-strand breaks. Furthermore, Ape1, coordinated with checkpoint kinase Chk2, regulates drug response of glioblastoma cells...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822880/children-s-developing-metaethical-judgments
#8
Marco F H Schmidt, Ivan Gonzalez-Cabrera, Michael Tomasello
Human adults incline toward moral objectivism but may approach things more relativistically if different cultures are involved. In this study, 4-, 6-, and 9-year-old children (N=136) witnessed two parties who disagreed about moral matters: a normative judge (e.g., judging that it is wrong to do X) and an antinormative judge (e.g., judging that it is okay to do X). We assessed children's metaethical judgment, that is, whether they judged that only one party (objectivism) or both parties (relativism) could be right...
August 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28792331/-remember-that-change-is-okay
#9
(no author information available yet)
Drew McDonald qualified as a children's nurse in 2005 from Robert Gordon University in Aberdeen. After working in neonatal care and on a medical ward at Royal Aberdeen Children's Hospital he moved to the emergency department, where he has worked for the past ten years. In May, he won the child health award at the 2017 RCNi Nurse Awards for developing a tool for identifying sepsis in children.
August 9, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28766440/more-than-a-golden-hello
#10
Janstarkers
Golden hellos for nurses are okay, but won't improve retention of staff. As soon as new recruits learn how short-staffed wards are and how few trained nurses are on shifts, they won't stay long anyway.
August 2, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28743438/fruit-and-vegetable-preferences-and-identification-by-kindergarteners-through-2nd-graders-with-or-without-the-us-department-of-agriculture-fresh-fruit-and-vegetable-program
#11
Natalie Masis, Susan L Johnson, Jennifer McCaffrey, Karen Chapman-Novakofski
OBJECTIVE: The US Department of Agriculture Fresh Fruit and Vegetable Program (FFVP) allows schools to increase fruit and vegetable (FV) exposure by distributing FV as snacks. The objective of this study was to compare kindergarten through second (K-2nd)-graders who were exposed or not to FFVP for preferences and identification. DESIGN, SETTING, PARTICIPANTS: The FV Preference Survey for K-2nd-graders contained 12 fruits and 12 vegetables, a 3-Likert scale (liked it, okay, don't like it), and an I don't know option...
October 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28697120/association-of-parasite-load-levels-in-amniotic-fluid-with-clinical-outcome-in-congenital-toxoplasmosis
#12
Lidia Yamamoto, Lília S Targa, Laura M Sumita, Paulo T Shimokawa, Jonatas C Rodrigues, Kelly A Kanunfre, Thelma S Okay
OBJECTIVE: To correlate neonatal and infant clinical outcome with parasite load in amniotic fluid (AF). METHODS: We conducted a retrospective cohort study of 122 children whose mothers had toxoplasmosis during pregnancy. The children were monitored from birth to 12 months old. Stored AF samples were obtained at maternal diagnosis and tested by quantitative polymerase chain reaction. Gestational age at maternal infection, quantitative polymerase chain reaction results, neonatal anti-Toxoplasma gondii immunoglobulin (Ig) M, and clinical outcome at 12 months were correlated...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28660805/contrast-induced-acute-kidney-injury-is-associated-with-long-term-adverse-events-in-patients-with-acute-coronary-syndrome
#13
Isil Uzunhasan, Ahmet Yildiz, Sukru Arslan, Okay Abaci, Cuneyt Kocas, Betul Balaban Kocas, Gokhan Cetinkal, Yalcin Dalgic, Osman Sukru Karaca, Sait Mesut Dogan
Contrast-induced acute kidney injury (CI-AKI) is associated with increased mortality, morbidity, and prolonged hospitalization. Patients with acute coronary syndrome (ACS) have a 3-fold higher risk of developing CI-AKI. The aim of our study was to evaluate the predictors of CI-AKI and long-term prognosis in patients with ACS who developed CI-AKI (1083 patients were enrolled). Contrast-induced acute kidney injury was defined as an increase of ≥0.5 mg/dL and/or an increase of ≥25% of pre-percutaneous coronary intervention (PCI) to post-PCI serum creatinine levels within 48 to 72 hours after the procedure...
August 2017: Angiology
https://www.readbyqxmd.com/read/28660514/monitoring-of-organic-pollutants-in-marine-environment-by-semipermeable-membrane-devices-and-mussels-accumulation-and-biochemical-responses
#14
Oya S Okay, Burak Karacık, Abbas Güngördü, Atilla Yılmaz, Nazmi C Koyunbaba, Sevil D Yakan, Bernhard Henkelmann, Karl-Werner Schramm, Murat Ozmen
This study involves the monitoring of organic pollutants using transplanted mussels (Mytilus galloprovincialis) as bioindicator organisms and semipermeable membrane devices (SPMDs) as passive samplers. Mussels and SPMDs were deployed to marinas, shipyards and shipbreaking yards on the coastal area of Turkey and retrieved after 60 days. Polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls (PCB) and organochlorine pesticide (OCP) compounds were analysed with high-resolution GC-MS. Total PAH concentrations in SPMDs and mussels ranged from 200 to 4740 ng g sampler(-1) and from 7...
June 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28648467/differentiating-could-from-should-developmental-changes-in-modal-cognition
#15
Andrew Shtulman, Jonathan Phillips
Young children have difficulty in distinguishing events that violate physical laws (impossible events) from those that violate mere physical regularities (improbable events). They judge both as "impossible." Young children also have difficulty in distinguishing events that violate moral laws (immoral events) from events that violate mere social regularities (unconventional events). They judge both as "wrong." In this set of studies, we explored the possibility that both difficulties arise from a more general deficit in modal cognition, or the way in which children represent and reason about possibilities...
January 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28630369/alpk3-gene-mutation-in-a-patient-with-congenital-cardiomyopathy-and-dysmorphic-features
#16
Ahmet Okay Çağlayan, Rabia Gonul Sezer, Hande Kaymakçalan, Ege Ulgen, Taner Yavuz, Jacob F Baranoski, Abdulkadir Bozaykut, Akdes Serin Harmanci, Yalim Yalcin, Mark W Youngblood, Katsuhito Yasuno, Kaya Bilgüvar, Murat Gunel
Primary cardiomyopathy is one of the most common inherited cardiac diseases and harbors significant phenotypic and genetic heterogeneity. Because of this, genetic testing has become standard in treatment of this disease group. Indeed, in recent years, next-generation DNA sequencing has found broad applications in medicine, both as a routine diagnostic tool for genetic disorders and as a high-throughput discovery tool for identifying novel disease-causing genes. We describe a male infant with primary dilated cardiomyopathy who was diagnosed using intrauterine echocardiography and found to progress to hypertrophic cardiomyopathy after birth...
September 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28599999/-tell-me-exactly-what-s-happened-when-linguistic-choices-affect-the-efficiency-of-emergency-calls-for-cardiac-arrest
#17
Marine Riou, Stephen Ball, Teresa A Williams, Austin Whiteside, Kay L O'Halloran, Janet Bray, Gavin D Perkins, Karen Smith, Peter Cameron, Daniel M Fatovich, Madoka Inoue, Paul Bailey, Deon Brink, Judith Finn
BACKGROUND: Clear and efficient communication between emergency caller and call-taker is crucial to timely ambulance dispatch. We aimed to explore the impact of linguistic variation in the delivery of the prompt "okay, tell me exactly what happened" on the way callers describe the emergency in the Medical Priority Dispatch System(®). METHODS: We analysed 188 emergency calls for cases of paramedic-confirmed out-of-hospital cardiac arrest. We investigated the linguistic features of the prompt "okay, tell me exactly what happened" in relation to the format (report vs...
August 2017: Resuscitation
https://www.readbyqxmd.com/read/28598542/overexpression-of-minichromosome-maintenance-protein-10-in-medulloblastoma-and-its-clinical-implications
#18
Daniel Senfter, Erdogan Pekcan Erkan, Erdener Özer, Gerhard Jungwirth, Sibylle Madlener, Marcel Kool, Thomas Ströbel, Nurten Saydam, Okay Saydam
BACKGROUND: Overexpression of minichromosome maintenance (MCM) proteins 2, 3, and 7 is associated with migration and invasion in medulloblastoma (MB). However, expression profiling of all prereplication complex (pre-RC) has not been addressed in MBs. PROCEDURE: We performed mRNA expression profiling of a large set of pre-RC elements in cell lines and tumor tissues of MB. RNAi technology was employed for functional studies in MB cell lines. RESULTS: Our data showed that most of the pre-RC components are significantly overexpressed in MB...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28582331/short-segment-spinal-instrumentation-in-early-onset-scoliosis-patients-treated-with-magnetically-controlled-growing-rods-surgical-technique-and-mid-short-term-outcomes
#19
Ahmed Majid Heydar, Serdar Şirazi, Erhan Okay, Murat Bezer
STUDY DESIGN: Prospective, a single institution, non-randomized study. OBJECTIVE: To evaluate the safety and effectivity of short-segment instrumentation in early onset scoliosis (EOS) patients treated by magnetic controlled growing rods (MCGR). SUMMERY OF BACKGROUND DATA: Despite the common use of conventional growing rods and the recent popularity of MCGR in the treatment of progressive EOS, distal instrumented vertebra and number of the spanned levels are not standardized...
June 2, 2017: Spine
https://www.readbyqxmd.com/read/28574116/the-influence-of-acetabular-morphology-on-prediction-of-proximal-femur-fractures-types-in-an-elderly-population
#20
Abbas Tokyay, Melih Güven, Mehmet E Encan, Erhan Okay, Ozgur Akbaba
INTRODUCTION: The role of proximal femur morphology to the development of certain proximal femur fracture types both femoral neck and trochanteric fractures has been observed. However, the relavance of acetabular morphology to the development of proximal femur fractures is not extensively questioned. Therefore the aim of the study was to determine whether there is a correlation between acetabular morphology and pathogenesis of 2 different hip fracture types after low energy trauma. METHODS: This retrospective study includes 60 cases (41 women, 19 men) with a proximal femoral fracture after a low energy trauma between July 2012 and December 2014...
September 19, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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