Christianah A Elusiyan, Ana Luiza Gonçalves Faria, Ane Emanuelle Queiroga Mendes, Iransé Oliveira Silva, José Luis Rodrigues Martins, Daniel Alves Rosa, Gustavo Rodrigues Pedrino, Elson Alves Costa, Mohamed Ali Ibrahim, Jordan K Zjawiony, James Oluwagbamigbe Fajemiroye
Tapinanthus globiferus is often referred to as an all-purpose herb for the treatment of stroke and epilepsy. The present study investigates the anticonvulsant effect of methanolic leaf extract, active fractions, and lupeol (isolate) of Tapinanthus globiferus in mice as well as the underlying mechanisms. Following phytochemical studies of T. globiferus , preliminary assays were performed to evaluate MLE-induced toxic effect and behavioral changes. The pentylenetetrazol (70 mg/kg, i. p.)-induced seizure was evaluated in mice that were pretreated orally with vehicle 10 mL/kg, MLE (4, 20, or 100 mg/kg), fractions (F1 to F6), lupeol 10 mg/kg or diazepam (3 mg/kg)...
November 2020: Planta Medica