Enrique Garcia-Gaona, Alhelí García-Gregorio, Camila García-Jiménez, Mildred Alejandra López-Olaiz, Paola Mendoza-Ramírez, Daniel Fernandez-Guzman, Rolando Alberto Pillado-Sánchez, Axel David Soto-Pacheco, Laura Yareni-Zuñiga, María Guadalupe Sánchez-Parada, Ana Elizabeth González-Santiago, Luis Miguel Román-Pintos, Rolando Castañeda-Arellano, Luis Daniel Hernández-Ortega, Arieh Roldán Mercado-Sesma, Felipe de Jesús Orozco-Luna, Carlos Villa-Angulo, Rafael Villa-Angulo, Raúl C Baptista-Rosas
Type 2 diabetes (T2D) is a chronic systemic disease with a complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted a secondary analysis of complete mtDNA sequences from 1261 T2D patients and 1105 control individuals. Our findings revealed significant associations between certain single-nucleotide polymorphisms (SNPs) and T2D. Notably, the variants m.1438A>G (rs2001030) (controls: 32 [27.6%], T2D: 84 [72.4%]; OR: 2...
October 30, 2023: Current Issues in Molecular Biology