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https://www.readbyqxmd.com/read/28648642/hpi-amf-inhibition-halts-the-development-of-the-aggressive-phenotype-of-breast-cancer-stem-cells
#1
Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Alvaro Marín-Hernández, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
Cancer stem cells are responsible for tumor recurrence and metastasis. A new highly reproducible procedure for human breast cancer MCF-7 stem cells (BCSC) isolation and selection was developed by using a combination of hypoxia/hypoglycemia plus taxol and adriamycin for 24h. The BCSC enriched fraction (i) expressed (2-15 times) the typical stemness protein markers CD44+, ALDH1A3 and Oct 3/4; (ii) increased its clonogenicity index (20-times), invasiveness profile (>70%), migration capacity (100%) and ability to form mammospheres, compared to its non-metastatic MCF-7 counterpart...
June 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28633735/angiolymphoid-hyperplasia-with-eosinophilia-of-the-nail-unit
#2
P Halteh, C Magro, S R Lipner
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a distinctive lymphocyte rich vasoformative proliferation comprising epithelioid-appearing endothelial cells with partially canalized capillary vessels in a lymphohistiocytic and eosinophil rich environment. ALHE presents clinically as single or multiple pink-brown dome-shaped papules or nodules, most commonly on the ear and peri-auricular area, followed by the face, and scalp. ALHE involving the subungual unit is rare with only 5 previously reported cases and all involved the underlying bone...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28603878/the-reactivity-of-nhc-alane-adducts-towards-n-heterocyclic-carbenes-and-cyclic-alkyl-amino-carbenes-ring-expansion-ring-opening-and-al-h-bond-activation
#3
Udo Radius, Heidi Schneider, Andreas Hock, Rüdiger Bertermann
The synthesis of the mono NHC alane adducts of the type (NHC)·AlH3 (NHC = Me2Im 1, Me2ImMe 2, iPr2Im 3 and 3-d3, iPr2ImMe 4, Dipp2Im 10) and (NHC)·AliBu2H (NHC = iPr2Im 11, Dipp2Im 12) as well as their reactivity towards different types of carbenes is presented. While the mono NHC adducts remain stable at elevated temperatures, ring expansion reaction occurs when (iPr2Im)·AlH3 3 is reacted with a second equivalent of the carbene iPr2Im to give (iPr2Im)·AlH(RER-iPr2ImH2) 6. In 6, {(iPr2Im}AlH} is inserted into the NHC ring...
June 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28599265/house-dust-endotoxin-and-peripheral-leukocyte-counts-results-from-two-large-epidemiologic-studies
#4
(no author information available yet)
BACKGROUND: The peripheral leukocyte count is a biomarker of inflammation and is associated with human all-cause mortality. Although causes of acute leukocytosis are well-described, chronic environmental determinants of leukocyte number are less well understood. OBJECTIVES: We investigated the relationship between house dust endotoxin concentration and peripheral leukocyte counts in human subjects. METHODS: The endotoxin-leukocyte relationship was evaluated by linear regression in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 () and the Agricultural Lung Health Study (ALHS; )...
May 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28589368/reassessing-risk-models-for-atypical-hyperplasia-age-may-not-matter
#5
REVIEW
Emanuele Mazzola, Suzanne B Coopey, Molly Griffin, Fernanda Polubriaginof, Julliette M Buckley, Giovanni Parmigiani, Judy E Garber, Barbara L Smith, Michele A Gadd, Michelle C Specht, Anthony Guidi, Kevin S Hughes
PURPOSE: The aim of this study was to investigate the influence of age at diagnosis of atypical hyperplasia ("atypia", ductal [ADH], lobular [ALH], or severe ADH) on the risk of developing subsequent invasive breast cancer or ductal carcinoma in situ (DCIS). METHODS: Using standard survival analysis methods, we retrospectively analyzed 1353 women not treated with chemoprevention among a cohort of 2370 women diagnosed with atypical hyperplasia to determine the risk relationship between age at diagnosis and subsequent breast cancer...
June 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28511526/angiolymphoid-hyperplasia-with-eosinophilia-involving-the-occipital-artery-case-report-and-review-of-literature
#6
Laia Fite-Trepat, Miriam Martos-Fernandez, Margarita Alberola-Ferranti, Alba De Pablo-Garcia-Cuenca, Coro Bescosatin
Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is an atypical vascular tumour occurring primarily in the head and neck area, which must be distinguished from Kimura's disease. The lesions can appear as single or multiple grouped intradermal papules or subcutaneous nodules. We report a rare case of ALHE in a 57-year-old female with a large lesion of three nodules involving the right occipital artery which had a long term evolution and we treated it by surgical excision. The definitive histopathological diagnosis was ALHE...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510589/establishment-of-a-combination-scoring-method-for-diagnosis-of-ocular-adnexal-lymphoproliferative-disease
#7
Xiao-Li Qu, Yan Hei, Li Kang, Xin-Ji Yang, Yi Wang, Xiao-Zhong Lu, Li-Hua Xiao, Guang Yang
Lymphoproliferative diseases (LPDs) of the ocular adnexa encompass the majority of orbital diseases and include reactive follicular hyperplasia (RFH), atypical lymphoid hyperplasia (ALH), and mucosa-associated lymphoid tissue lymphoma (MALToma). Lymphoid follicles (LFs) are usually observed during the histological examination of LPDs. Currently, because there is a lack of specific clinical signs and diagnostic immunohistochemical biomarkers, it is difficult for pathologists to distinguish MALToma from ocular RFH and ALH, which makes the clinical management of these conditions difficult...
2017: PloS One
https://www.readbyqxmd.com/read/28428286/a-genetic-analysis-of-the-caenorhabditis-elegans-detoxification-response
#8
Tetsunari Fukushige, Harold E Smith, Johji Miwa, Michael W Krause, John A Hanover
Oxidative damage contributes to human diseases of aging including diabetes, cancer, and cardiovascular disorders. Reactive oxygen species resulting from xenobiotic and endogenous metabolites are sensed by a poorly understood process, triggering a cascade of regulatory factors and leading to the activation of the transcription factor Nrf2 (SKN-1 in Caenorhabditis elegans). Nrf2/SKN-1 activation promotes the induction of the Phase II detoxification system that serves to limit oxidative stress. We have extended a previous C...
April 19, 2017: Genetics
https://www.readbyqxmd.com/read/28416376/seminal-plasma-removal-by-density-gradient-centrifugation-is-superior-for-goat-sperm-preservation-compared-with-classical-sperm-washing
#9
J Santiago-Moreno, M C Esteso, C Castaño, A Toledano-Díaz, J A Delgadillo, A López-Sebastián
Seminal plasma removal is routine in goat sperm cryopreservation protocols. The classical washing procedure designed to accomplish this usually leaves the pellet resulting from use of this procedure contaminated with dead sperm, debris, and cells other than sperm. This contamination negatively affects viability of sperm after cryopreservation. The present research was conducted to compare the effect on chilled and frozen-thawed goat sperm of the classical washing method to that of a selective washing method involving density gradient centrifugation (DGC)...
April 9, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28280973/determinants-of-curvature-constant-w-of-the-power-duration-relationship-under-normoxia-and-hypoxia-the-effect-of-pre-exercise-alkalosis
#10
Sanjoy K Deb, Lewis A Gough, S Andy Sparks, Lars R McNaughton
PURPOSE: This study investigated the effect of induced alkalosis on the curvature constant (W') of the power-duration relationship under normoxic and hypoxic conditions. METHODS: Eleven trained cyclists (mean ± SD) Age: 32 ± 7.2 years; body mass (bm): 77.0 ± 9.2 kg; VO2peak: 59.2 ± 6.8 ml·kg(-1)·min(-1) completed seven laboratory visits which involved the determination of individual time to peak alkalosis following sodium bicarbonate (NaHCO3) ingestion, an environment specific ramp test (e...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28280835/ring-opening-of-cyclic-ethers-by-aluminum-hydridotriphenylborate
#11
Debabrata Mukherjee, Hassan Osseili, Khai-Nghi Truong, Thomas P Spaniol, Jun Okuda
Molecular aluminum hydride [(L)AlH2] (L = Me3TACD) reacted with 2 equiv. of BPh3 in THF or THP to give the cationic alkoxides [(L)Al(OR)][HBPh3] (R = nBu, nPent) by facile ring-opening of the cyclic ethers. The Cα-O bond cleavage which involves the isolable intermediate [(L)AlH][HBPh3] is a result of hydride transfer to Cα from [HBPh3](-).
March 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28215454/sperm-quality-and-oxidative-status-as-affected-by-homogenization-of-liquid-stored-boar-semen-diluted-in-short-and-long-term-extenders
#12
Mariana B Menegat, Ana Paula G Mellagi, Rafael C Bortolin, Tila A Menezes, Amanda R Vargas, Mari Lourdes Bernardi, Ivo Wentz, Daniel P Gelain, José Cláudio F Moreira, Fernando P Bortolozzo
Homogenization of diluted boar semen during storage has for a long time been regarded as beneficial. Recent studies indicated an adverse effect of homogenization on sperm quality for yet unknown reasons. This study aimed to verify the effect of homogenization on sperm parameters and to elucidate the impact of oxidative stress. Twenty-one normospermic ejaculates (21 boars) were diluted with Androstar(®) Plus (AND) and Beltsville Thawing Solution (BTS). Semen doses were submitted to no-homogenization (NoHom) or twice-a-day manual homogenization (2xHom) during storage at 17°C for 168h...
April 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28040460/kimura-s-disease-in-a-50-year-old-tunisian-man
#13
M Drouillard, M Steve, T Ranoarivony, J-B Souraud
INTRODUCTION: Kimura's disease is an uncommon disease of unknown aetiology affecting men in their thirties from Southeast Asia. The authors report a case of Kimura's disease in a 50-year-old Tunisian man that was diagnosed after surgery. CASE REPORT: This patient had two 2-cm diameter chronic nodular lesions over the right mandible with no local inflammation and no other clinical findings of systemic disease. Histopathological examination showed germinal centre hyperplasia, eosinophilic micro-abscesses and hyperplasia of postcapillary venules, suggestive of Kimura's disease, which was confirmed by the laboratory work-up: elevated total IgE (519g/L), and eosinophilia (580/mm(3))...
December 28, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28035701/three-unusual-histopathological-presentations-of-angiolymphoid-hyperplasia-with-eosinophilia
#14
Angel Fernandez-Flores, David S Cassarino
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a poorly understood benign vasculoproliferative disorder. Histopathologically, the lesions are composed of a dermal or subcutaneous proliferation of blood vessels of varying sizes with plump and bland endothelial cells, which often show vacuolization and protrusion of the cytoplasm into the lumen. The vascular proliferation is admixed with a diffuse inflammatory infiltrate composed of lymphocytes, eosinophils and mast cells. Lymphoid follicles with germinal centers can sometimes be seen...
March 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28012719/cysteamine-supplementation-revealed-detrimental-effect-on-cryosurvival-of-buffalo-sperm-based-on-computer-assisted-semen-analysis-and-oxidative-parameters
#15
Dheer Singh Swami, Pradeep Kumar, R K Malik, Monika Saini, Dharmendra Kumar, M H Jan
The aim of this study was to investigate the effect of addition of cysteamine to the semen extender on post-thaw semen quality. A total of 30 ejaculates were collected from six bulls. Each ejaculate was divided into five equal parts and diluted to final concentration of 80 million sperms/mL using Optixcell(®)(IMV, France) semen extender supplemented with different concentrations of cysteamine (0, 0.75, 1.25, 2.5 and 5mM) and cryopreserved. In the frozen-thawed samples, the VAP, VSL, VCL ALH and sperm motility of control samples was greater (P<0...
February 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/27936312/synthesis-characterization-and-computational-analysis-of-the-dialanate-dianion-h3-al-alh3-2-a-valence-isoelectronic-analogue-of-ethane
#16
Simon J Bonyhady, Nicole Holzmann, Gernot Frenking, Andreas Stasch, Cameron Jones
The first example of a well-defined binary, low-oxidation-state aluminum hydride species that is stable at ambient temperature, namely the dianion in [{((Dep) Nacnac)Mg}2 (μ-H)]2 [H3 Al-AlH3 ] ((Dep) Nacnac=[(DepNCMe)2 CH](-) , Dep=2,6-diethylphenyl), has been prepared via a magnesium(I) reduction of the alanate complex, ((Dep) Nacnac)Mg(μ-H)3 AlH(NEt3 ). An X-ray crystallographic analysis has shown the compound to be a contact ion complex, which computational studies have revealed to be the source of the stability of the aluminum(II) dianion...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27895910/proteomic-identification-of-cryostress-in-epididymal-spermatozoa
#17
Sung Jae Yoon, Md Saidur Rahman, Woo Sung Kwon, Do Yeal Ryu, Yoo Jin Park, Myung Geol Pang
BACKGROUND: Cryopreservation of epididymal spermatozoa is important in cases in which it is not possible to collect semen using normal methods, as the sudden death of an animal or a catastrophic injury. However, the freezing and thawing processes cause stress to spermatozoa, including cold shock, osmotic damage, and ice crystal formation, thereby reducing sperm quality. We assessed the motility (%), motion kinematics, capacitation status, and viability of spermatozoa using computer-assisted sperm analysis and Hoechst 33258/chlortetracycline fluorescence staining...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27887759/implementing-an-open-access-casa-software-for-the-assessment-of-stallion-sperm-motility-relationship-with-other-sperm-quality-parameters
#18
Elisa Giaretta, Mauro Munerato, Marc Yeste, Giovanna Galeati, Marcella Spinaci, Carlo Tamanini, Gaetano Mari, Diego Bucci
Setting an open-access computer assisted sperm analysis (CASA) may benefit the evaluation of motility in mammalian sperm, especially when economic constraints do not allow the use of a commercial system. There have been successful attempts to develop such a device in Zebra fish sperm and the system has been used in very few studies on mammalian spermatozoa. Against this background, the present study aimed at developing an open-access CASA system for mammalian sperm using the horse as a model and based upon the Image J software previously established for Zebra fish sperm...
January 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/27832842/flat-epithelial-atypia-on-core-needle-biopsy-must-we-surgically-excise
#19
A A Acott, A T Mancino
Breast flat epithelial atypia (FEA) often coexists with more aggressive pathology and excision is currently recommended when diagnosed by core needle biopsy (CNB). Recent studies suggest isolated FEA has a low association with carcinoma and may warrant close surveillance. A radiology database containing 2189 breast CNB was reviewed for isolated FEA or FEA in combination with atypical pathology. 79 patients had FEA. There were 48/79 with isolated FEA and 31/79 concomitant FEA with ADH, ALH, or LCIS. 46 subsequent excisional biopsies of isolated FEA resulted: benign 38/46, ADH 5/46, LCIS 2/46, DCIS 1/46...
December 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27773974/pparg-lyplal1-multi-allelic-combination-associated-with-obesity-and-overweight-in-mexican-adolescent-females
#20
Esther Alhelí Hernández-Tobías, Luisa Torres-Sánchez, Gino Noris, Carla Santana, María Reyna Samano, José Arellano-Galindo, María de la Luz Arenas-Sordo, Daniel Brooks, Ana Lilia Rodríguez-Ventura, Marco Antonio Meraz-Ríos, Rocío Gómez
OBJECTIVE: We studied multi-loci variants to identify the contribution of six candidate genes (ADIPOQ, CDH13, LYPLAL1, MC4R, PPARG and PGC1A) in the development of obesity and overweight. DESIGN: We genotyped 404 chromosomes with eleven SNPs in Mexican female adolescents, who were subdivided into two groups (obesity-overweight and normal-weight) using the World Health Organization parameters. Genomic (800 chromosomes) and ancestral (208 chromosomes) controls were included to reduce the population bias...
October 20, 2016: Ethnicity & Disease
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