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Esther Alhelí Hernández-Tobías, Luisa Torres-Sánchez, Gino Noris, Carla Santana, María Reyna Samano, José Arellano-Galindo, María de la Luz Arenas-Sordo, Daniel Brooks, Ana Lilia Rodríguez-Ventura, Marco Antonio Meraz-Ríos, Rocío Gómez
OBJECTIVE: We studied multi-loci variants to identify the contribution of six candidate genes (ADIPOQ, CDH13, LYPLAL1, MC4R, PPARG and PGC1A) in the development of obesity and overweight. DESIGN: We genotyped 404 chromosomes with eleven SNPs in Mexican female adolescents, who were subdivided into two groups (obesity-overweight and normal-weight) using the World Health Organization parameters. Genomic (800 chromosomes) and ancestral (208 chromosomes) controls were included to reduce the population bias...
October 20, 2016: Ethnicity & Disease
C Fives, C J O'Neill, R Murphy, M A Corrigan, M J O'Sullivan, L Feeley, M W Bennett, F O'Connell, T J Browne
BACKGROUND: The diagnosis and management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) remains controversial. Current management options after a core needle biopsy (CNB) with lobular neoplasia (LN) incorporating both ALH and LCIS include excision biopsy or careful clinical and radiologic follow up. METHODS: A retrospective analysis of the surgical database at Cork University Hospital was performed to identify all core needle biopsies from January 1st 2010 to 31st December 2013 with a diagnosis of FA who subsequently underwent surgical excision biopsy...
October 3, 2016: Breast: Official Journal of the European Society of Mastology
Melissa Murray
Percutaneous imaging-guided core needle biopsy (CNB) is a less invasive and less expensive alternative to surgical biopsy for the evaluation of breast lesions. After a CNB the radiologist determine if there is concordance between the pathology, imaging, and clinical findings. Patient management after CNB diagnosis of high-risk breast lesion varies. Surgical excision is warranted for lesions yielding a CNB diagnosis of ADH; however controversy exists regarding the need for surgical excision after CNB diagnosis of radial scar, papillary lesion, atypical lobular hyperplasia (ALH), or lobular carcinoma in situ (LCIS)...
September 27, 2016: Clinical Obstetrics and Gynecology
A Ntemka, G Tsousis, C Brozos, E Kiossis, C M Boscos, I A Tsakmakidis
The objective of this study was to investigate the quality of frozen-thawed semen from different bull breeds. Commercial frozen-thawed bull semen samples (26 per breed, 130 totally) of five breeds (Holstein [Η], Brown Swiss [BS], Limousin [L], Belgian Blue [BB], Blonde d' Aquitaine [BA]) were used. After thawing, each semen sample was subjected to thermal resistance test (TR) for 0.5 and 1 hr at 38°C and hypo-osmotic swelling test (HOST) for 1 hr at 150 mOsm at 37°C. Additionally, all samples were evaluated at times 0 hr (thawing), 0...
September 25, 2016: Reproduction in Domestic Animals, Zuchthygiene
Pilar Santolaria, Carles Soler, Pilar Recreo, Teresa Carretero, Araceli Bono, José M Berné, Jesús L Yániz
This study was designed to analyze the sperm kinematic and morphometric subpopulations in the different fractions of the ejaculate in normozoospermic men. Ejaculates from eight normozoospermic men were collected by masturbation in three fractions after 3-5 days of sexual abstinence. Analyses of sperm motility by computer-assisted sperm analysis (CASA-Mot), and of sperm morphometry by computer-assisted sperm morphometry analysis (CASA-Morph) using fluorescence were performed. Clustering and discriminant procedures were performed to identify sperm subpopulations in the kinematic and morphometric data obtained...
September 13, 2016: Asian Journal of Andrology
Erif Maha Nugraha Setyawan, Min Jung Kim, Hyun Ju Oh, Geon A Kim, Young Kwang Jo, Seok Hee Lee, Yoo Bin Choi, Byeong Chun Lee
The objective of this study was to determine the ability of spermine to act as an antioxidant in scavenging reactive oxygen species (ROS), maintaining sperm function and decreasing cryocapacitation after cryopreservation. Although motility did not increase with spermine treatment, values for membrane integrity were significantly increased (P < 0.05). Higher percentages of linearity and straightness with a lower amplitude of lateral head displacement (ALH) indicated that spermine inhibits hyperactivation...
October 28, 2016: Biochemical and Biophysical Research Communications
Vineet Kumar Jakhar, Milan Kr Barman, Sharanappa Nembenna
The well-defined aluminum monohydride compound [{(2,4,6-Me3-C6H2)NC(Me)}2(Me)(H)]AlH·(NMe2Et) (1) catalyzes hydroboration of a wide range of aldehydes and ketones under mild reaction conditions. Moreover, compound 1 displayed chemoselective hydroboration of aldehydes over ketones at rt.
September 16, 2016: Organic Letters
Lauren Q Chang Sen, Wendie A Berg, Regina J Hooley, Gloria J Carter, Mohamed M Desouki, Jules H Sumkin
OBJECTIVE: The purpose of this article is to determine the upgrade rate to ductal carcinoma in situ (DCIS) or invasive carcinoma at excision at the same site after percutaneous breast biopsy findings of atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS) using current imaging and strict pathologic criteria. MATERIALS AND METHODS: From January 2006 through September 2013, 32,960 breast core biopsies were performed; 1084 (3.3%) core biopsies found ALH or classic LCIS...
November 2016: AJR. American Journal of Roentgenology
Se Eun Kim, Tae Hyun Kim, Shin Ae Park, Won Tae Kim, Young Woo Park, Jae Sang Ahn, Manbok Jeong, Min-Young Kim, Kangmoon Seo
Matrix metalloproteinases (MMPs) are the main proteinase associated with periodontal tissue destruction and remodeling. Therefore, inhibition of the host-derived MMPs is accounted to play a key role in the prevention and reduction of the periodontitis progression. Horse chestnut (Aesculus hippocastanum L.) extracts had been used as a remedy for inflammatory disease, traditionally. This study was performed to assess the clinical effect of ALH-L1005 on the periodontitis as MMPs inhibitor. ALH-L1005 was obtained from horse chestnut leaf and the MMPs inhibitory activities were estimated...
August 10, 2016: Journal of Veterinary Science
Joaquín Cordero-Martínez, Charmina Aguirre-Alvarado, Jessica Gabriela Guzmán-Soriano, Cinthia Erika Sánchez-Arroyo, Juan Carlos Flores-Alonso, Lorena Rodríguez-Páez
UNLABELLED: The present study evaluates the possible antifertility effect of aqueous crude extract (OBACE) of Echeveria gibbiflora, a plant that belongs to the crassulaceae family, used in traditional Mexican medicine as a vaginal post coital rinse to prevent pregnancy and shown to have an immobilization/agglutination effect on sperm of different mammal species. We evaluated the effect of OBACE on functional parameters of mouse sperm, such as viability, capacitation, and acrosome reaction...
October 2016: Systems Biology in Reproductive Medicine
G P Nicolson, Alh McGrath, R A Webster, J Li, S Kaye, R Malik, N J Beijerink
OBJECTIVE: The purpose of this study was to determine through measurement of cardiac biomarkers whether there was cardiac involvement in dogs infested with Ixodes holocyclus. METHODS: Dogs with tick paralysis and no-mild (group 1; n = 44) or moderate-severe respiratory compromise (group 2; n = 36) and a control group of dogs (n = 31) were enrolled. Plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP), serum cardiac troponin I (cTnI) and serum creatinine concentrations were determined...
August 2016: Australian Veterinary Journal
Christina L Duncan, Paul T Enlow, Margo M Szabo, Eric Tolchin, Robert W Kelly, Lourdes Castanon, Ariel M Aballay
OBJECTIVE: Research suggests that active Leptospermum honey (ALH) improves outcomes in patients with partial-thickness burns by enhancing healing and reepithelialization rates, as well as by protecting against antibiotic-resistant microorganisms. This study assessed the effectiveness of ALH gel on healing time, bacterial growth, patient satisfaction, and cost of treatment. DESIGN: Single-arm, prospective case series. SETTING AND PATIENTS: Seven patients (aged 7-64 years) with partial-thickness facial burns were recruited from a northeastern US burn center...
August 2016: Advances in Skin & Wound Care
Barbara Susnik, Deborah Day, Ellen Abeln, Tara Bowman, Janet Krueger, Karen K Swenson, Michaela L Tsai, Margit L Bretzke, Tamera J Lillemoe
BACKGROUND: Management recommendations for lobular neoplasia (LN) including lobular carcinoma-in-situ (LCIS) and atypical lobular hyperplasia (ALH) diagnosed in core biopsies (CB) are controversial. Our aim was to prospectively identify a subset of patients who do not require subsequent surgical excision (SE). PATIENTS AND METHODS: All patients diagnosed with LN on CB were enrolled and referred for SE. Cases with coexistent ductal carcinoma-in-situ or invasive carcinoma were excluded...
June 14, 2016: Clinical Breast Cancer
E Lopez-Urueña, L Anel-López, S Borragan, C Ortega Ferrusola, P Manrique, P de Paz, L Anel, M Alvarez
Sedimentation of spermatozoa occurs during long-term liquid storage and this may produce deleterious changes. Our aim was to apply gelatine supplementation during long-term pre-freezing storage of bear sperm, applying final dilution and 6% glycerol at room temperature and cool in straws. We tested four models of sperm storage using a 1:1 dilution in TTF-ULE-Bear extender (TesT-fructose-egg yolk-glycerol 6%): (i) second 1:1 dilution at room temperature (RT), cooling at 5°C in a tube and final dilution (100 × 10(6)  sperm ml(-1) ) (Standard); (ii) final dilution at RT and cooling in a tube (FD-Tube); (iii) final dilution at RT and cooling in 0...
October 2016: Reproduction in Domestic Animals, Zuchthygiene
Amy C Degnim, William D Dupont, Derek C Radisky, Robert A Vierkant, Ryan D Frank, Marlene H Frost, Stacey J Winham, Melinda E Sanders, Jeffrey R Smith, David L Page, Tanya L Hoskin, Celine M Vachon, Karthik Ghosh, Tina J Hieken, Lori A Denison, Jodi M Carter, Lynn C Hartmann, Daniel W Visscher
BACKGROUND: Women with atypical hyperplasia (AH) on breast biopsy have a substantially increased risk of breast cancer (BC). Here the BC risk for the extent and subtype of AH is reported for 2 separate cohorts. METHODS: All samples containing AH were included from 2 cohorts of women with benign breast disease (Mayo Clinic and Nashville). Histology review quantified the number of foci of atypical ductal hyperplasia (ADH) and atypical lobular hyperplasia (ALH). The BC risk was stratified for the number of AH foci within AH subtypes...
October 2016: Cancer
Israel Salazar-Báez, Jessica E Salazar-Campos, Alhely López-Arias, Verónica Villavicencio-Valencia, Jaime Coronel-Martínez, Myrna Candelaria-Hernández, Delia Pérez-Montiel, Carlos Pérez-Plasencia, Aurora Elizabeth Rojas-García, David Cantú de León
Vulvar cancer accounts for approximately 4% of gynecological malignancies. At the Instituto Nacional de Cancerologia in Mexico it occupies the fourth place. The purpose of this study is to assess the management of squamous carcinoma of the vulva with initial surgical treatment. It is a descriptive retrospective, observational study, from January 1, 2002 to December 31, 2012. Twenty-seven patients, clinical stages I, II, or III, initial surgical management, with at least one year of follow-up were included. In 51...
May 2016: Gaceta Médica de México
Jorge I Castañeda-Sánchez, Diana Alhelí Domínguez-Martínez, Nataly Olivar-Espinosa, Blanca Estela García-Pérez, María Alba Loroño-Pino, Julieta Luna-Herrera, Ma Isabel Salazar
BACKGROUND/AIMS: The innate immune response is remarkably important for controlling infections. Information about the participation of antimicrobial peptides (AMPs) in response to dengue virus (DENV) is scarce. The aim of this study was to examine the AMP response to DENV-2 in human THP-1 cells and neutrophils. METHODS: Protein and mRNA levels of two AMPs - hBD-1 and cathelicidin LL-37 - were assessed in DENV-infected macrophage-like THP-1 cells using qRT-PCR and indirect immunofluorescence...
2016: Intervirology
Peter M Schmidt, Michael Abdo, Rebecca E Butcher, Min-Yin Yap, Pierre D Scotney, Melanie L Ramunno, Genevieve Martin-Roussety, Catherine Owczarek, Matthew P Hardy, Chao-Guang Chen, Louis J Fabri
Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion US$ in 2013. The selection of lead candidate molecules involves the generation of large repertoires of antibodies from which to choose a final therapeutic candidate. Improvements in the ability to rapidly produce and purify many antibodies in sufficient quantities reduces the lead time for selection which ultimately impacts on the speed with which an antibody may transition through the research stage and into product development...
July 15, 2016: Journal of Chromatography. A
Steffen Styra, Michael Radius, Eric Moos, Angela Bihlmeier, Frank Breher
The synthesis and characterisation of two aluminium diphosphamethanide complexes, [Al(tBu)2 {κ(2) P,P'-Mes*PCHPMes*}] (3) and [Al(C6 F5 )2 {κ(2) P,P'-Mes*PCHPMes*}] (4), and the silylated analogue, Mes*PCHP(SiMe3 )Mes* (5), are reported. The aluminium complexes feature four-membered PCPAl core structures consisting of diphosphaallyl ligands. The silylated phosphine 5 was found to be a valuable precursor for the synthesis of 4 as it cleanly reacts with the diaryl aluminium chloride [(C6 F5 )2 AlCl]2 . The aluminium complex 3 reacts with molecular dihydrogen at room temperature under formation of the acyclic σ(2) λ(3) ,σ(3) λ(3) -diphosphine Mes*PCHP(H)Mes* and the corresponding dialkyl aluminium hydride [tBu2 AlH]3 ...
July 4, 2016: Chemistry: a European Journal
Pushpa Rani Guvvala, Selvaraju Sellappan, Ravindra Janivara Parameswaraiah
The arsenic (As) is a multi system effector including reproduction. The present study examined the association of graded doses of As(V) on testicular microenvironment and sperm function in mice. Thirty-six adult male mice were randomly assigned to six groups (n = 6). Group A served as control without test chemical. The groups B, C, D, E, and F were administered graded doses of 10, 25, 50, 100, and 200 ppm As(V), respectively, through drinking water for 40 days. A dose-dependant significant (P < 0...
September 2016: Environmental Science and Pollution Research International
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