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https://www.readbyqxmd.com/read/28095420/molecular-mechanism-of-disease-associated-mutations-in-the-pre-m1-helix-of-nmda-receptors-and-potential-rescue-pharmacology
#1
Kevin K Ogden, Wenjuan Chen, Sharon A Swanger, Miranda J McDaniel, Linlin Z Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J Kosobucki, Anthony J Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E Cohen, Elias Aizenman, Stephen F Traynelis, Hongjie Yuan
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits show the strongest signal for being depleted of missense variants. We find that this includes the GluN2 pre-M1 helix and linker between the agonist-binding domain (ABD) and first transmembrane domain (M1). We then evaluate the functional changes of multiple missense mutations in the NMDAR pre-M1 helix found in children with epilepsy and developmental delay...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28093750/what-is-a-jungian-analyst-dreaming-when-myth-comes-to-mind-thirdness-as-an-aspect-of-the-anima-media-natura
#2
August J Cwik
Listening analytically is not listening just to what is said but listening to what is just below the surface waiting to be said. This paper looks at Jung's insight into a 'third thing' being created intra-psychically and within the analytic encounter. Ogden's concept of an 'analytic third' is used to describe the clinical aspects of this thirdness. This paper explores: how the state of thirdness is created and accessed through use of reverie and associative dreaming; how the material emerging from it is used in a from or about manner; and the eventual fate of the third in a successful analysis by a reexamination of plates four and ten of the Rosarium...
February 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28091803/a-study-of-hyperelastic-models-for-predicting-the-mechanical-behavior-of-extensor-apparatus
#3
Nahid Elyasi, Kimia Karimi Taheri, Keivan Narooei, Ali Karimi Taheri
In this research, the nonlinear elastic behavior of human extensor apparatus was investigated. To this goal, firstly the best material parameters of hyperelastic strain energy density functions consisting of the Mooney-Rivlin, Ogden, invariants, and general exponential models were derived for the simple tension experimental data. Due to the significance of stress response in other deformation modes of nonlinear models, the calculated parameters were used to study the pure shear and balance biaxial tension behavior of the extensor apparatus...
January 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28076965/predictors-of-burnout-and-health-status-in-samaritans-listening-volunteers
#4
Adeline Roche, Jane Ogden
Samaritan listening volunteers provide emotional support to people in distress or suicidal. Samaritans' has high volunteer turnover, which may be due to burnout. This study evaluated the role of demographic and psychosocial factors in predicting Samaritans listening volunteers' burnout and health status. Samaritans' listening volunteers (n = 216) from seven branches across UK completed an online survey to assess their levels of burnout (emotional exhaustion, depersonalisation, personal accomplishment), subjective health status, coping, empathy and social support...
January 11, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28063639/characterization-of-the-polarity-of-subcritical-water
#5
Zahra M Alghoul, Phillip B Ogden, John G Dorsey
The polarity of subcritical water was studied solvatochromically with betaine dye (33) across a temperature range of 30°C-180°C and a pressure range of 13.8bar (200psi) to 124bar (1800psi). It was observed that temperature has a greater effect than pressure on the polarity of subcritical water. In addition, subcritical water was compared with traditional hydro-organic mobile phases and the polarity of subcritical water was found to be comparable to a range of 30%-50% methanol/water and a range of 20%-30% acetonitrile/water mobile phases...
December 28, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28052859/ashp-guidelines-on-preventing-diversion-of-controlled-substances
#6
Philip W Brummond, David F Chen, William W Churchill, John S Clark, Kevin R Dillon, Doina Dumitru, Lynn Eschenbacher, Toni Fera, Christopher R Fortier, Kristine K Gullickson, Kristen Jurakovich, Stan Kent, Jennifer Keonavong, Christine Marchese, Tricia Meyer, Lee B Murdaugh, Richard K Ogden, Brian C O'Neal, Steve Rough, Rafael Saenz, Jacob S Smith
No abstract text is available yet for this article.
January 4, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28052481/quinoline-derived-two-photon-sensitive-quadrupolar-probes
#7
Christine Tran, Nawel Berqouch, Hamid Dhimane, Guillaume Clermont, Mireille Blanchard-Desce, David Ogden, Peter I Dalko
Quadrupolar probes derived from 8-dimethylamino-quinoline (8-DMAQ) having a pegylated fluorene core were prepared and studied under "one-photon" (λ=365 nm) and "two-photon" (TP) (λ=730 nm) irradiation conditions. Compound 1 a was identified as the most efficient probe by UV activation that showed sequential release of acetic acid as a model. Although the probe showed high two-photon absorption it stayed inert under femtosecond irradiation conditions. Fast and selective photolysis was observed, however, by using picosecond irradiation conditions with a remarkably high TP uncaging cross-section (δu =2...
January 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28048440/su-g-iep2-12-the-effect-of-iterative-reconstruction-and-ct-tube-voltage-on-hounsfield-unit-values-of-iodinated-contrast
#8
K Ogden, K Greene-Donnelly, D Vallabhaneni, E Scalzetti
PURPOSE: To investigate the effects of changing iterative reconstruction strength and tube voltage on Hounsfield Unit (HU) values of varying concentrations of Iodinated contrast medium in a phantom. METHOD: Iodinated contrast (Omnipaque 300, GE Healthcare, Princeton NJ) was diluted with distilled water to concentrations of 0.6, 0.9, 1.8, 3.6, 7.2, and 10.8 mg/mL of Iodine. The solutions were scanned in a patient equivalent water phantom on two MDCT scanners: VCT 64 slice (GE Medical Systems, Waukesha, WI) and an Aquilion One 320 slice scanner (Toshiba America Medical Systems, Tustin CA)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048162/su-f-r-08-can-normalization-of-brain-mri-texture-features-reduce-scanner-dependent-effects-in-unsupervised-machine-learning
#9
K Ogden, T Bradford, L Cussen, R O'Dwyer
PURPOSE: To reduce differences in features calculated from MRI brain scans acquired at different field strengths with or without Gadolinium contrast. METHODS: Brain scans were processed for 111 epilepsy patients to extract hippocampus and thalamus features. Scans were acquired on 1.5 T scanners with Gadolinium contrast (group A), 1.5T scanners without Gd (group B), and 3.0 T scanners without Gd (group C). A total of 72 features were extracted. Features were extracted from original scans and from scans where the image pixel values were rescaled to the mean of the hippocampi and thalami values...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012233/angiomatoid-fibrous-histiocytoma-a-case-of-local-recurrence-and-metastases-to-loco-regional-lymph-nodes-that-responded-to-chemotherapy
#10
Sally Ogden, Srikrishna Harave, Jo McPartland, Bernadette Brennan, Lee Jeys, Paul Losty, Barry Pizer
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour with intermediate malignant potential. We report the case of a patient with local recurrence of AFH in two locations and lymph node metastases 18 months after primary surgical excision. The patient was treated with six cycles of ifosfamide and doxorubicin chemotherapy and a further three courses of ifosfamide monotherapy. Reassessment imaging showed a good response to chemotherapy with reduction in size of the two tumours of local recurrence and the lymph node metastases...
December 24, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28007279/recovery-of-a-missile-embolus-from-the-right-ventricle
#11
Clement D Marshall, Michael R Ma, Julia Park, Clifford C Sheckter, Rustin A Massoudi, Cathleen M Ligman, Ronald M Jou, William D Ogden
Missile embolism is a clinical entity in which a projectile object enters a blood vessel and is carried to a distant part of the body. We present a case of the discovery of an iliac vein to right ventricle missile embolus in a young man, with successful extraction through a right atriotomy. We provide a historical overview of the literature concerning missile embolism, and we argue that whereas acute embolized projectiles should be removed in almost all cases, it may be reasonable to simply observe an asymptomatic chronic missile embolus...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28002488/the-accuracy-of-diagnostic-tests-for-lyme-disease-in-humans-a-systematic-review-and-meta-analysis-of-north-american-research
#12
Lisa A Waddell, Judy Greig, Mariola Mascarenhas, Shannon Harding, Robbin Lindsay, Nicholas Ogden
There has been an increasing incidence of Lyme disease (LD) in Canada and the United States corresponding to the expanding range of the Ixodes tick vector and Lyme disease agent (Borrelia burgdorferi sensu stricto). There are many diagnostic tests for LD available in North America, all of which have some performance issues, and physicians are concerned about the appropriate use and interpretation of these tests. The objective of this systematic review is to summarize the North American evidence on the accuracy of diagnostic tests and test regimes at various stages of LD...
2016: PloS One
https://www.readbyqxmd.com/read/27992097/looking-for-answers-to-bariatric-surgery-for-losing-weight-using-resting-state-functional-mri
#13
Bin Zhang
No abstract text is available yet for this article.
December 19, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27989920/mechanical-characterization-of-human-brain-tissue
#14
S Budday, G Sommer, C Birkl, C Langkammer, J Haybaeck, J Kohnert, M Bauer, F Paulsen, P Steinmann, E Kuhl, G A Holzapfel
: Mechanics are increasingly recognized to play an important role in modulating brain form and function. Computational simulations are a powerful tool to predict the mechanical behavior of the human brain in health and disease. The success of these simulations depends critically on the underlying constitutive model and on the reliable identification of its material parameters. Thus, there is an urgent need to thoroughly characterize the mechanical behavior of brain tissue and to identify mathematical models that capture the tissue response under arbitrary loading conditions...
October 27, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27981608/contrasting-results-from-molecular-and-pedigree-based-population-diversity-measures-in-captive-zebra-highlight-challenges-facing-genetic-management-of-zoo-populations
#15
Hideyuki Ito, Rob Ogden, Tanya Langenhorst, Miho Inoue-Murayama
Zoo conservation breeding programs manage the retention of population genetic diversity through analysis of pedigree records. The range of demographic and genetic indices determined through pedigree analysis programs allows the conservation of diversity to be monitored relative to the particular founder population for a species. Such approaches are based on a number of well-documented founder assumptions, however without knowledge of actual molecular genetic diversity there is a risk that pedigree-based measures will be misinterpreted and population genetic diversity misunderstood...
December 15, 2016: Zoo Biology
https://www.readbyqxmd.com/read/27956224/impact-of-a-park-based-afterschool-program-replicated-over-five-years-on-modifiable-cardiovascular-disease-risk-factors
#16
Sarah E Messiah, Denise Vidot, Eric Hansen, Jack Kardys, M Sunil Matthew, Maria Nardi, Kristopher L Arheart
Major challenges to the current childhood obesity epidemic include availability of prevention and/or treatment programs that are affordable and acc5essible. We evaluated the change in several modifiable, obesity-related cardiovascular disease risk factors after participation in Fit2Play™, a structured afterschool program housed in a large urban county parks system. Children ages 6-14 who participated in Fit2Play™ in one of 34 parks for one school year during a five-year period (2010-2015) had height, weight, 4-site skinfold thicknesses, systolic/diastolic blood pressure (SBP/DBP), fitness tests, and a health/wellness behavior/knowledge test collected at the beginning and end of the school year...
December 10, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27951752/the-differential-recruitment-of-short-term-memory-and-executive-functions-during-time-number-and-length-perception-an-individual-differences-approach
#17
Ruth S Ogden, Michael Samuels, Fiona Simmons, John Wearden, Catharine Montgomery
Developmental, behavioural and neurological similarities in the processing of different magnitudes (time, number, space) support the existence of a common magnitude processing system (e.g. ATOM; Bueti & Walsh, 2009; Walsh, 2003). It is however unclear whether the recruitment of wider cognitive resources (STM and executive function) during magnitude processing is similar across magnitude domains or domain specific. The current study used an individual differences approach to examine the relationship between STM, executive function and magnitude processing...
December 13, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27935519/the-role-of-obesity-in-the-relation-between-total-water-intake-and-urine-osmolality-in-us-adults-2009-2012
#18
Asher Y Rosinger, Hannah G Lawman, Lara J Akinbami, Cynthia L Ogden
BACKGROUND: Adequate water intake is critical to physiologic and cognitive functioning. Although water requirements increase with body size, it remains unclear whether weight status modifies the relation between water intake and hydration status. OBJECTIVE: We examined how the association between water intake and urine osmolality, which is a hydration biomarker, varied by weight status. DESIGN: NHANES cross-sectional data (2009-2012) were analyzed in 9601 nonpregnant adults aged ≥20 y who did not have kidney failure...
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27930271/there-is-inadequate-evidence-to-support-the-division-of-the-genus-borrelia
#19
Gabriele Margos, Durdica Marosevic, Sally Cutler, Marketa Derdakova, Maria Diuk-Wasser, Stefan Emler, Durland Fish, Jeremy Gray, Klaus-Peter Hunfeld, Benoit Jaulhac, Olaf Kahl, Sergey Kovalev, Peter Kraiczy, Robert S Lane, Reto Lienhard, Per-Eric Lindgren, Nicholas Ogden, Katharina Ornstein, Tobias Rupprecht, Ira Schwartz, Andreas Sing, Reinhard K Straubinger, Franc Strle, Maarten Voordouw, Annapaola Rizzoli, Brian Stevenson, Volker Fingerle
No abstract text is available yet for this article.
December 8, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27928010/structural-insights-into-reovirus-%C3%AF-1-interactions-with-two-neutralizing-antibodies
#20
Melanie H Dietrich, Kristen M Ogden, Sarah P Katen, Kerstin Reiss, Danica M Sutherland, Robert H Carnahan, Matthew Goff, Tracy Cooper, Terence S Dermody, Thilo Stehle
: Reovirus attachment protein σ1 engages glycan receptors and junctional adhesion molecule-A (JAM-A) and is thought to undergo a conformational change during the proteolytic disassembly of virions to infectious subvirion particles (ISVPs) that accompanies cell entry. The σ1 protein is also the primary target of neutralizing antibodies. Here we present a structural and functional characterization of two neutralizing antibodies that target σ1 of serotypes 1 (T1) and 3 (T3) reoviruses...
December 7, 2016: Journal of Virology
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