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https://www.readbyqxmd.com/read/28218755/changes-in-the-incidence-patterns-and-outcomes-of-graft-failure-following-hematopoietic-stem-cell-transplantation-for-hurler-syndrome
#1
S H Lum, W P Miller, S Jones, K Poulton, W Ogden, H Lee, A Logan, D Bonney, T C Lund, P J Orchard, R F Wynn
Hematopoietic stem cell transplantation (HSCT) is the standard of care in children with Hurler syndrome (HS) as it is the only therapy that can arrest disease progression. We examined the incidence, patterns and outcomes of graft failure in all HS children undergoing first HSCT at the Royal Manchester Children's Hospital or the University of Minnesota Children's Hospital from 1983 to 2016. Implementation of busulfan pharmacokinetic monitoring started in 2004 in both institutions. Two hundred and forty HS children were included in this analysis (historical era (pre-2004), n=131; current era (post 2004), n=109)...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218233/multi-institutional-study-of-nuclear-kifc1-as-a-biomarker-of-poor-prognosis-in-african-american-women-with-triple-negative-breast-cancer
#2
Angela Ogden, Chakravarthy Garlapati, Xiaoxian Bill Li, Ravi Chakra Turaga, Gabriela Oprea-Ilies, Nikita Wright, Shristi Bhattarai, Karuna Mittal, Ceyda Sönmez Wetherilt, Uma Krishnamurti, Michelle D Reid, Mildred Jones, Meenakshi Gupta, Remus Osan, Sonal Pattni, Ansa Riaz, Sergey Klimov, Arundhati Rao, Guilherme Cantuaria, Padmashree C G Rida, Ritu Aneja
Nuclear KIFC1 (nKIFC1) predicts worse outcomes in breast cancer, but its prognostic value within racially distinct triple-negative breast cancer (TNBC) patients is unknown. Thus, nKIFC1 expression was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarrays (TMAs) pooled from four hospitals. nKIFC1 correlated significantly with Ki67 in White TNBCs but not in AA TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. High nKIFC1 weighted index (WI) was associated with significantly worse overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (Hazard Ratios [HRs] = 3...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28213608/trends-in-anthropometric-measures-among-us-children-6-to-23-months-1976-2014
#3
Lara J Akinbami, Brian K Kit, Margaret D Carroll, Tala H I Fakhouri, Cynthia L Ogden
BACKGROUND AND OBJECTIVES: The surveillance of children's growth reflects a population's nutritional status and risk for adverse outcomes. This study aimed to describe trends in length-for-age, weight-for-age, weight-for-length, and early childhood weight gain among US children aged 6 to 23 months. METHODS: We analyzed NHANES data from 1976-1980, 1988-1994, 1999-2002, 2003-2006, 2007-2010, and 2011-2014. We estimated z scores < -2 (low) and ≥+2 (high) in comparison with World Health Organization growth standards for each indicator...
February 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/28182723/antibody-responses-to-borrelia-burgdorferi-detected-by-western-blot-vary-geographically-in-canada
#4
Nicholas H Ogden, Julie Arsenault, Todd F Hatchette, Samir Mechai, L Robbin Lindsay
Lyme disease is emerging in eastern and central Canada, and most cases are diagnosed using the two-tier serological test (Enzyme Immuno Assay [EIA] followed by Western blot [WB]). Simplification of this algorithm would be advantageous unless it impacts test performance. In this study, accuracy of individual proteins of the IgG WB algorithm in predicting the overall test result in samples from Canadians was assessed. Because Borrelia burgdorferi strains vary geographically in Canada, geographic variations in serological responses were also explored...
2017: PloS One
https://www.readbyqxmd.com/read/28157545/a-comparison-of-structural-connectivity-in-anxious-depression-versus-non-anxious-depression
#5
Lauren Delaparte, Fang-Cheng Yeh, Phil Adams, Ashley Malchow, Madhukar H Trivedi, Maria A Oquendo, Thilo Deckersbach, Todd Ogden, Diego A Pizzagalli, Maurizio Fava, Crystal Cooper, Melvin McInnis, Benji T Kurian, Myrna M Weissman, Patrick J McGrath, Daniel N Klein, Ramin V Parsey, Christine DeLorenzo
BACKGROUND: Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals...
January 24, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28127388/how-to-implement-illness-management-and-recovery-imr-in-mental-health-service-settings-evaluation-of-the-implementation-strategy
#6
Karina Myhren Egeland, Torleif Ruud, Terje Ogden, Rickard Färdig, Jonas Christoffer Lindstrøm, Kristin Sverdvik Heiervang
BACKGROUND: The purpose of this study was to evaluate the implementation strategy used in the first-phase of implementation of the Illness Management and Recovery (IMR) programme, an intervention for adults with severe mental illnesses, in nine mental health service settings in Norway. METHODS: A total of 9 clinical leaders, 31 clinicians, and 44 consumers at 9 service settings participated in the implementation of IMR. Implementation was conducted by an external team of researchers and an experienced trainer...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28125649/investigation-of-a-medieval-pilgrim-burial-excavated-from-the-leprosarium-of-st-mary-magdalen-winchester-uk
#7
Simon Roffey, Katie Tucker, Kori Filipek-Ogden, Janet Montgomery, Jamie Cameron, Tamsin O'Connell, Jane Evans, Phil Marter, G Michael Taylor
We have examined the remains of a Pilgrim burial from St Mary Magdalen, Winchester. The individual was a young adult male, aged around 18-25 years at the time of death. Radiocarbon dating showed the remains dated to the late 11th-early 12th centuries, a time when pilgrimages were at their height in Europe. Several lines of evidence in connection with the burial suggested this was an individual of some means and prestige. Although buried within the leprosarium cemetery, the skeleton showed only minimal skeletal evidence for leprosy, which was confined to the bones of the feet and legs...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28122631/risk-of-travel-related-cases-of-zika-virus-infection-is-predicted-by-transmission-intensity-in-outbreak-affected-countries
#8
Nicholas H Ogden, Aamir Fazil, David Safronetz, Michael A Drebot, Justine Wallace, Erin E Rees, Kristina Decock, Victoria Ng
BACKGROUND: Zika virus (ZIKV) infection is emerging globally, currently causing outbreaks in the Caribbean, and Central and South America, and putting travellers to affected countries at risk. Model-based estimates for the basic reproduction number (R 0 ) of ZIKV in affected Caribbean and Central and South American countries, obtained from 2015 to 2016 human case surveillance data, were compared by logistic regression and Receiver-Operating Characteristic (ROC), with the prevalence of ZIKV-positive test results in Canadians who travelled to them...
January 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28122201/in%C3%A2-vivo-measurement-of-pde10a-enzyme-occupancy-by-positron-emission-tomography-pet-following-single-oral-dose-administration-of-pf-02545920-in-healthy-male-subjects
#9
Marielle Delnomdedieu, Anton Forsberg, Adam Ogden, Patrik Fazio, Ching-Ray Yu, Per Stenkrona, Sridhar Duvvuri, William David, Nabil Al-Tawil, Ottavio V Vitolo, Nahid Amini, Sangram Nag, Christer Halldin, Andrea Varrone
Phosphodiesterase 10A (PDE10A) is an enzyme highly enriched in the striatal medium spiny neurons. It is involved in the regulation of cytoplasmic levels of cAMP and cGMP and signaling within the basal ganglia. This study with PDE10A radioligand [(18)F]MNI-659 was designed to measure the enzyme occupancy of PF-02545920 in 8 healthy male volunteers (48 ± 4 years) after a single oral dose (10 mg or 20 mg) and to evaluate safety and tolerability. Arterial blood sampling was performed to obtain a metabolite-corrected plasma input function for the quantification of [(18)F]MNI-659 binding to PDE10A...
January 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28112566/costs-of-providing-infusion-therapy-for-patients-with-inflammatory-bowel-disease-in-a-hospital-based-infusion-center-setting
#10
Anita Afzali, Kristine Ogden, Michael L Friedman, Jingdong Chao, Anthony Wang
Aims Inflammatory bowel disease (IBD) (e.g., ulcerative colitis [UC] and Crohn's disease [CD]) severely impacts patient quality of life. Moderate to severe disease is often treated with biologics requiring infusion therapy, adding incremental costs beyond drug costs. This study evaluates US hospital-based infusion services costs for treatment of UC or CD patients receiving infliximab or vedolizumab therapy. Materials and methods A model was developed, estimating annual costs of providing monitored infusions using activity-based costing framework approach...
January 23, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28095420/molecular-mechanism-of-disease-associated-mutations-in-the-pre-m1-helix-of-nmda-receptors-and-potential-rescue-pharmacology
#11
Kevin K Ogden, Wenjuan Chen, Sharon A Swanger, Miranda J McDaniel, Linlin Z Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J Kosobucki, Anthony J Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E Cohen, Elias Aizenman, Stephen F Traynelis, Hongjie Yuan
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits show the strongest signal for being depleted of missense variants. We find that this includes the GluN2 pre-M1 helix and linker between the agonist-binding domain (ABD) and first transmembrane domain (M1). We then evaluate the functional changes of multiple missense mutations in the NMDAR pre-M1 helix found in children with epilepsy and developmental delay...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28093750/what-is-a-jungian-analyst-dreaming-when-myth-comes-to-mind-thirdness-as-an-aspect-of-the-anima-media-natura
#12
August J Cwik
Listening analytically is not listening just to what is said but listening to what is just below the surface waiting to be said. This paper looks at Jung's insight into a 'third thing' being created intra-psychically and within the analytic encounter. Ogden's concept of an 'analytic third' is used to describe the clinical aspects of this thirdness. This paper explores: how the state of thirdness is created and accessed through use of reverie and associative dreaming; how the material emerging from it is used in a from or about manner; and the eventual fate of the third in a successful analysis by a reexamination of plates four and ten of the Rosarium...
February 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28091803/a-study-of-hyperelastic-models-for-predicting-the-mechanical-behavior-of-extensor-apparatus
#13
Nahid Elyasi, Kimia Karimi Taheri, Keivan Narooei, Ali Karimi Taheri
In this research, the nonlinear elastic behavior of human extensor apparatus was investigated. To this goal, firstly the best material parameters of hyperelastic strain energy density functions consisting of the Mooney-Rivlin, Ogden, invariants, and general exponential models were derived for the simple tension experimental data. Due to the significance of stress response in other deformation modes of nonlinear models, the calculated parameters were used to study the pure shear and balance biaxial tension behavior of the extensor apparatus...
January 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28076965/predictors-of-burnout-and-health-status-in-samaritans-listening-volunteers
#14
Adeline Roche, Jane Ogden
Samaritan listening volunteers provide emotional support to people in distress or suicidal. Samaritans' has high volunteer turnover, which may be due to burnout. This study evaluated the role of demographic and psychosocial factors in predicting Samaritans listening volunteers' burnout and health status. Samaritans' listening volunteers (n = 216) from seven branches across UK completed an online survey to assess their levels of burnout (emotional exhaustion, depersonalisation, personal accomplishment), subjective health status, coping, empathy and social support...
January 11, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28063639/characterization-of-the-polarity-of-subcritical-water
#15
Zahra M Alghoul, Phillip B Ogden, John G Dorsey
The polarity of subcritical water was studied solvatochromically with betaine dye (33) across a temperature range of 30°C-180°C and a pressure range of 13.8bar (200psi) to 124bar (1800psi). It was observed that temperature has a greater effect than pressure on the polarity of subcritical water. In addition, subcritical water was compared with traditional hydro-organic mobile phases and the polarity of subcritical water was found to be comparable to a range of 30%-50% methanol/water and a range of 20%-30% acetonitrile/water mobile phases...
February 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28052859/ashp-guidelines-on-preventing-diversion-of-controlled-substances
#16
Philip W Brummond, David F Chen, William W Churchill, John S Clark, Kevin R Dillon, Doina Dumitru, Lynn Eschenbacher, Toni Fera, Christopher R Fortier, Kristine K Gullickson, Kristen Jurakovich, Stan Kent, Jennifer Keonavong, Christine Marchese, Tricia Meyer, Lee B Murdaugh, Richard K Ogden, Brian C O'Neal, Steve Rough, Rafael Saenz, Jacob S Smith
No abstract text is available yet for this article.
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28052481/quinoline-derived-two-photon-sensitive-quadrupolar-probes
#17
Christine Tran, Nawel Berqouch, Hamid Dhimane, Guillaume Clermont, Mireille Blanchard-Desce, David Ogden, Peter I Dalko
Quadrupolar probes derived from 8-dimethylamino-quinoline (8-DMAQ) having a pegylated fluorene core were prepared and studied under "one-photon" (λ=365 nm) and "two-photon" (TP) (λ=730 nm) irradiation conditions. Compound 1 a was identified as the most efficient probe by UV activation that showed sequential release of acetic acid as a model. Although the probe showed high two-photon absorption it stayed inert under femtosecond irradiation conditions. Fast and selective photolysis was observed, however, by using picosecond irradiation conditions with a remarkably high TP uncaging cross-section (δu =2...
January 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28048440/su-g-iep2-12-the-effect-of-iterative-reconstruction-and-ct-tube-voltage-on-hounsfield-unit-values-of-iodinated-contrast
#18
K Ogden, K Greene-Donnelly, D Vallabhaneni, E Scalzetti
PURPOSE: To investigate the effects of changing iterative reconstruction strength and tube voltage on Hounsfield Unit (HU) values of varying concentrations of Iodinated contrast medium in a phantom. METHOD: Iodinated contrast (Omnipaque 300, GE Healthcare, Princeton NJ) was diluted with distilled water to concentrations of 0.6, 0.9, 1.8, 3.6, 7.2, and 10.8 mg/mL of Iodine. The solutions were scanned in a patient equivalent water phantom on two MDCT scanners: VCT 64 slice (GE Medical Systems, Waukesha, WI) and an Aquilion One 320 slice scanner (Toshiba America Medical Systems, Tustin CA)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048162/su-f-r-08-can-normalization-of-brain-mri-texture-features-reduce-scanner-dependent-effects-in-unsupervised-machine-learning
#19
K Ogden, T Bradford, L Cussen, R O'Dwyer
PURPOSE: To reduce differences in features calculated from MRI brain scans acquired at different field strengths with or without Gadolinium contrast. METHODS: Brain scans were processed for 111 epilepsy patients to extract hippocampus and thalamus features. Scans were acquired on 1.5 T scanners with Gadolinium contrast (group A), 1.5T scanners without Gd (group B), and 3.0 T scanners without Gd (group C). A total of 72 features were extracted. Features were extracted from original scans and from scans where the image pixel values were rescaled to the mean of the hippocampi and thalami values...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012233/angiomatoid-fibrous-histiocytoma-a-case-of-local-recurrence-and-metastases-to-loco-regional-lymph-nodes-that-responded-to-chemotherapy
#20
Sally Ogden, Srikrishna Harave, Jo McPartland, Bernadette Brennan, Lee Jeys, Paul Losty, Barry Pizer
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour with intermediate malignant potential. We report the case of a patient with local recurrence of AFH in two locations and lymph node metastases 18 months after primary surgical excision. The patient was treated with six cycles of ifosfamide and doxorubicin chemotherapy and a further three courses of ifosfamide monotherapy. Reassessment imaging showed a good response to chemotherapy with reduction in size of the two tumours of local recurrence and the lymph node metastases...
December 24, 2016: Pediatric Blood & Cancer
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