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https://www.readbyqxmd.com/read/28325915/prognostic-value-of-ca20-a-score-based-on-centrosome-amplification-associated-genes-in-breast-tumors
#1
Angela Ogden, Padmashree C G Rida, Ritu Aneja
Centrosome amplification (CA) is a hallmark of cancer, observable in ≥75% of breast tumors. CA drives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness. Thus, assessment of CA may offer insights into the prognosis of breast cancer and identify patients who might benefit from centrosome declustering agents. However, it remains unclear whether CA is correlated with clinical outcomes after adjusting for confounding factors. To gain insights, we developed a signature, "CA20", comprising centrosome structural genes and genes whose dysregulation is implicated in inducing CA...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323694/assessment-of-paraspinal-muscle-cross-sectional-area-after-lumbar-decompression-minimally-invasive-versus-open-approaches
#2
Lacey E Bresnahan, Justin S Smith, Alfred T Ogden, Steven Quinn, George R Cybulski, Narina Simonian, Raghu N Natarajan, Richard D Fessler, Richard G Fessler
STUDY DESIGN: A retrospective, blinded analysis of imaging studies. SUMMARY OF BACKGROUND DATA: To evaluate changes in paraspinal muscle cross-sectional area (CSA) after surgical treatment for lumbar stenosis and to compare these changes between minimally invasive and standard open approaches. The open approach to lumbar stenosis is effective, but it involves retraction and resection of muscle from the spinous process, which can result in ischemia and denervation of paraspinal musculature and may lead to muscle atrophy and pain...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28300489/a-postgraduation-follow-up-of-social-work-students-trained-in-sbirt-rates-of-usage-and-perceptions-of-effectiveness
#3
Evan Senreich, Lydia P Ogden, Joy Pastan Greenberg
Screening, brief intervention, and referral to treatment (SBIRT) is an evidence-based modality that can help social workers work with substance-using clients as part of an integrated health care approach. This study reports the findings of a post-graduation one-year follow-up survey of 193 master's and bachelor's social work students trained in SBIRT in practice courses at a Northeast urban college. Forty-three percent of the trainees who were practicing social work after graduation were using SBIRT. A content analysis of participants' comments found that the vast majority found SBIRT to be a valuable practice modality, with barriers to utilization of SBIRT identified...
March 16, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28284370/frequency-and-associated-clinical-features-of-functional-tricuspid-regurgitation-in-patients-with-chronic-atrial%C3%A2-fibrillation
#4
Susan X Zhao, Nima Soltanzad, Aravind Swaminathan, W David Ogden, Nelson B Schiller
Significant functional tricuspid regurgitation (TR) can develop in some but not all patients with chronic atrial fibrillation (AF). This study sought to identify factors likely to be involved in determining the severity of TR in patients with chronic AF. In this retrospective cohort study of adult patients referred for transthoracic echocardiography for evaluation of AF between 2004 and 2015, we identified 170 patients with chronic AF in the absence of structural or known coronary heart disease. Patients were classified into nonsevere (89 patients) versus severe TR (81 patients) groups based on a comprehensive assessment of color Doppler, spectral Doppler, and morphologic parameters of the tricuspid valve and right side of the heart...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28272828/dreaming-the-analytic-session-a-clinical-essay
#5
Thomas H Ogden
This is a clinical paper in which the author describes analytic work in which he dreams the analytic session with three of his patients. He begins with a brief discussion of aspects of analytic theory that make up a good deal of the context for his clinical work. Central among these concepts are (1) the idea that the role of the analyst is to help the patient dream his previously "undreamt" and "interrupted" dreams; and (2) dreaming the analytic session involves engaging in the experience of dreaming the session with the patient and, at the same time, unconsciously (and at times consciously) understanding the dream...
January 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28272508/amplified-centrosomes-and-mitotic-index-display-poor-concordance-between-patient-tumors-and-cultured-cancer-cells
#6
Karuna Mittal, Da Hoon Choi, Angela Ogden, Shashi Donthamsetty, Brian D Melton, Meenakshi V Gupta, Vaishali Pannu, Guilherme Cantuaria, Sooryanarayana Varambally, Michelle D Reid, Kristin Jonsdottir, Emiel A M Janssen, Mohammad A Aleskandarany, Ian O Ellis, Emad A Rakha, Padmashree C G Rida, Ritu Aneja
Centrosome aberrations (CA) and abnormal mitoses are considered beacons of malignancy. Cancer cell doubling times in patient tumors are longer than in cultures, but differences in CA between tumors and cultured cells are uncharacterized. We compare mitoses and CA in patient tumors, xenografts, and tumor cell lines. We find that mitoses are rare in patient tumors compared with xenografts and cell lines. Contrastingly, CA is more extensive in patient tumors and xenografts (~35-50% cells) than cell lines (~5-15%), although CA declines in patient-derived tumor cells over time...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28263410/mixture-markov-regression-model-with-application-to-mosquito-surveillance-data-analysis
#7
Xin Gao, Yurong R Cao, Nicholas Ogden, Louise Aubin, Huaiping P Zhu
A mixture Markov regression model is proposed to analyze heterogeneous time series data. Mixture quasi-likelihood is formulated to model time series with mixture components and exogenous variables. The parameters are estimated by quasi-likelihood estimating equations. A modified EM algorithm is developed for the mixture time series model. The model and proposed algorithm are tested on simulated data and applied to mosquito surveillance data in Peel Region, Canada.
March 6, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28258640/realistic-kinetic-loading-of-the-jaw-system-during-single-chewing-cycles-a-finite-element-study
#8
S E Martinez Choy, J Lenz, K Schweizerhof, M Schmitter, H J Schindler
Although knowledge of short-range kinetic interactions between antagonistic teeth during mastication is of essential importance for ensuring interference-free fixed dental reconstructions, little information is available. In this study, the forces on and displacements of the teeth during kinetic molar biting simulating the power stroke of a chewing cycle were investigated by use of a finite-element model that included all the essential components of the human masticatory system, including an elastic food bolus...
March 4, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28245098/bmi-z-scores-are-a-poor-indicator-of-adiposity-among-2-to-19-year-olds-with-very-high-bmis-nhanes-1999-2000-to-2013-2014
#9
David S Freedman, Nancy F Butte, Elsie M Taveras, Elizabeth A Lundeen, Heidi M Blanck, Alyson B Goodman, Cynthia L Ogden
OBJECTIVE: Although the Centers for Disease Control and Prevention (CDC) growth charts are widely used, BMI-for-age z-Scores (BMIz) are known to be uninformative above the 97th percentile. This study compared the relations of BMIz and other BMI metrics (%BMIp95 , percent of 95th percentile, and ΔBMIp95 , BMI minus 95th percentile) to circumferences, skinfolds, and fat mass. We were particularly interested in the differences among children with severe obesity (%BMIp95  ≥ 120). METHODS: Data was used from 30,003 2- to 19-year-olds who were examined from 1999-2000 through 2013-2014 in the National Health and Nutrition Examination Survey (NHANES)...
February 28, 2017: Obesity
https://www.readbyqxmd.com/read/28218755/changes-in-the-incidence-patterns-and-outcomes-of-graft-failure-following-hematopoietic-stem-cell-transplantation-for-hurler-syndrome
#10
S H Lum, W P Miller, S Jones, K Poulton, W Ogden, H Lee, A Logan, D Bonney, T C Lund, P J Orchard, R F Wynn
Hematopoietic stem cell transplantation (HSCT) is the standard of care in children with Hurler syndrome (HS) as it is the only therapy that can arrest disease progression. We examined the incidence, patterns and outcomes of graft failure in all HS children undergoing first HSCT at the Royal Manchester Children's Hospital or the University of Minnesota Children's Hospital from 1983 to 2016. Implementation of busulfan pharmacokinetic monitoring started in 2004 in both institutions. Two hundred and forty HS children were included in this analysis (historical era (pre-2004), n=131; current era (post 2004), n=109)...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218233/multi-institutional-study-of-nuclear-kifc1-as-a-biomarker-of-poor-prognosis-in-african-american-women-with-triple-negative-breast-cancer
#11
Angela Ogden, Chakravarthy Garlapati, Xiaoxian Bill Li, Ravi Chakra Turaga, Gabriela Oprea-Ilies, Nikita Wright, Shristi Bhattarai, Karuna Mittal, Ceyda Sönmez Wetherilt, Uma Krishnamurti, Michelle D Reid, Mildred Jones, Meenakshi Gupta, Remus Osan, Sonal Pattni, Ansa Riaz, Sergey Klimov, Arundhati Rao, Guilherme Cantuaria, Padmashree C G Rida, Ritu Aneja
Nuclear KIFC1 (nKIFC1) predicts worse outcomes in breast cancer, but its prognostic value within racially distinct triple-negative breast cancer (TNBC) patients is unknown. Thus, nKIFC1 expression was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarrays (TMAs) pooled from four hospitals. nKIFC1 correlated significantly with Ki67 in White TNBCs but not in AA TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. High nKIFC1 weighted index (WI) was associated with significantly worse overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (Hazard Ratios [HRs] = 3...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28213608/trends-in-anthropometric-measures-among-us-children-6-to-23-months-1976-2014
#12
Lara J Akinbami, Brian K Kit, Margaret D Carroll, Tala H I Fakhouri, Cynthia L Ogden
BACKGROUND AND OBJECTIVES: The surveillance of children's growth reflects a population's nutritional status and risk for adverse outcomes. This study aimed to describe trends in length-for-age, weight-for-age, weight-for-length, and early childhood weight gain among US children aged 6 to 23 months. METHODS: We analyzed NHANES data from 1976-1980, 1988-1994, 1999-2002, 2003-2006, 2007-2010, and 2011-2014. We estimated z scores < -2 (low) and ≥+2 (high) in comparison with World Health Organization growth standards for each indicator...
February 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/28182723/antibody-responses-to-borrelia-burgdorferi-detected-by-western-blot-vary-geographically-in-canada
#13
Nicholas H Ogden, Julie Arsenault, Todd F Hatchette, Samir Mechai, L Robbin Lindsay
Lyme disease is emerging in eastern and central Canada, and most cases are diagnosed using the two-tier serological test (Enzyme Immuno Assay [EIA] followed by Western blot [WB]). Simplification of this algorithm would be advantageous unless it impacts test performance. In this study, accuracy of individual proteins of the IgG WB algorithm in predicting the overall test result in samples from Canadians was assessed. Because Borrelia burgdorferi strains vary geographically in Canada, geographic variations in serological responses were also explored...
2017: PloS One
https://www.readbyqxmd.com/read/28157545/a-comparison-of-structural-connectivity-in-anxious-depression-versus-non-anxious-depression
#14
Lauren Delaparte, Fang-Cheng Yeh, Phil Adams, Ashley Malchow, Madhukar H Trivedi, Maria A Oquendo, Thilo Deckersbach, Todd Ogden, Diego A Pizzagalli, Maurizio Fava, Crystal Cooper, Melvin McInnis, Benji T Kurian, Myrna M Weissman, Patrick J McGrath, Daniel N Klein, Ramin V Parsey, Christine DeLorenzo
BACKGROUND: Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (FA) and density of selected white matter tracts and amygdala volume between anxious depressed and non-anxious depressed individuals...
January 24, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28127388/how-to-implement-illness-management-and-recovery-imr-in-mental-health-service-settings-evaluation-of-the-implementation-strategy
#15
Karina Myhren Egeland, Torleif Ruud, Terje Ogden, Rickard Färdig, Jonas Christoffer Lindstrøm, Kristin Sverdvik Heiervang
BACKGROUND: The purpose of this study was to evaluate the implementation strategy used in the first-phase of implementation of the Illness Management and Recovery (IMR) programme, an intervention for adults with severe mental illnesses, in nine mental health service settings in Norway. METHODS: A total of 9 clinical leaders, 31 clinicians, and 44 consumers at 9 service settings participated in the implementation of IMR. Implementation was conducted by an external team of researchers and an experienced trainer...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28125649/investigation-of-a-medieval-pilgrim-burial-excavated-from-the-leprosarium-of-st-mary-magdalen-winchester-uk
#16
Simon Roffey, Katie Tucker, Kori Filipek-Ogden, Janet Montgomery, Jamie Cameron, Tamsin O'Connell, Jane Evans, Phil Marter, G Michael Taylor
We have examined the remains of a Pilgrim burial from St Mary Magdalen, Winchester. The individual was a young adult male, aged around 18-25 years at the time of death. Radiocarbon dating showed the remains dated to the late 11th-early 12th centuries, a time when pilgrimages were at their height in Europe. Several lines of evidence in connection with the burial suggested this was an individual of some means and prestige. Although buried within the leprosarium cemetery, the skeleton showed only minimal skeletal evidence for leprosy, which was confined to the bones of the feet and legs...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28122631/risk-of-travel-related-cases-of-zika-virus-infection-is-predicted-by-transmission-intensity-in-outbreak-affected-countries
#17
Nicholas H Ogden, Aamir Fazil, David Safronetz, Michael A Drebot, Justine Wallace, Erin E Rees, Kristina Decock, Victoria Ng
BACKGROUND: Zika virus (ZIKV) infection is emerging globally, currently causing outbreaks in the Caribbean, and Central and South America, and putting travellers to affected countries at risk. Model-based estimates for the basic reproduction number (R 0 ) of ZIKV in affected Caribbean and Central and South American countries, obtained from 2015 to 2016 human case surveillance data, were compared by logistic regression and Receiver-Operating Characteristic (ROC), with the prevalence of ZIKV-positive test results in Canadians who travelled to them...
January 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28122201/in%C3%A2-vivo-measurement-of-pde10a-enzyme-occupancy-by-positron-emission-tomography-pet-following-single-oral-dose-administration-of-pf-02545920-in-healthy-male-subjects
#18
Marielle Delnomdedieu, Anton Forsberg, Adam Ogden, Patrik Fazio, Ching-Ray Yu, Per Stenkrona, Sridhar Duvvuri, William David, Nabil Al-Tawil, Ottavio V Vitolo, Nahid Amini, Sangram Nag, Christer Halldin, Andrea Varrone
Phosphodiesterase 10A (PDE10A) is an enzyme highly enriched in the striatal medium spiny neurons. It is involved in the regulation of cytoplasmic levels of cAMP and cGMP and signaling within the basal ganglia. This study with PDE10A radioligand [(18)F]MNI-659 was designed to measure the enzyme occupancy of PF-02545920 in 8 healthy male volunteers (48 ± 4 years) after a single oral dose (10 mg or 20 mg) and to evaluate safety and tolerability. Arterial blood sampling was performed to obtain a metabolite-corrected plasma input function for the quantification of [(18)F]MNI-659 binding to PDE10A...
January 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28112566/costs-of-providing-infusion-therapy-for-patients-with-inflammatory-bowel-disease-in-a-hospital-based-infusion-center-setting
#19
Anita Afzali, Kristine Ogden, Michael L Friedman, Jingdong Chao, Anthony Wang
AIMS: Inflammatory bowel disease (IBD) (e.g. ulcerative colitis [UC] and Crohn's disease [CD]) severely impacts patient quality-of-life. Moderate-to-severe disease is often treated with biologics requiring infusion therapy, adding incremental costs beyond drug costs. This study evaluates US hospital-based infusion services costs for treatment of UC or CD patients receiving infliximab or vedolizumab therapy. MATERIALS AND METHODS: A model was developed, estimating annual costs of providing monitored infusions using an activity-based costing framework approach...
April 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28095420/molecular-mechanism-of-disease-associated-mutations-in-the-pre-m1-helix-of-nmda-receptors-and-potential-rescue-pharmacology
#20
Kevin K Ogden, Wenjuan Chen, Sharon A Swanger, Miranda J McDaniel, Linlin Z Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J Kosobucki, Anthony J Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E Cohen, Elias Aizenman, Stephen F Traynelis, Hongjie Yuan
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits show the strongest signal for being depleted of missense variants. We find that this includes the GluN2 pre-M1 helix and linker between the agonist-binding domain (ABD) and first transmembrane domain (M1). We then evaluate the functional changes of multiple missense mutations in the NMDAR pre-M1 helix found in children with epilepsy and developmental delay...
January 2017: PLoS Genetics
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