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Anton Suvorov, Nicholas O Jensen, Camilla R Sharkey, M Stanley Fujimoto, Paul Bodily, Haley M Cahill Wightman, T Heath Ogden, Mark J Clement, Seth M Bybee
Gene duplication plays a central role in adaptation to novel environments by providing new genetic material for functional divergence and evolution of biological complexity. Several evolutionary models have been proposed for gene duplication to explain how new gene copies are preserved by natural selection but these models have rarely been tested using empirical data. Opsin proteins, when combined with a chromophore, form a photopigment that is responsible for the absorption of light, the first step in the phototransduction cascade...
October 18, 2016: Molecular Ecology
Christine DeLorenzo, Jean-Dominique Gallezot, John Gardus, Jie Yang, Beata Planeta, Nabeel Nabulsi, R Todd Ogden, David C Labaree, Yiyun H Huang, J John Mann, Fabrizio Gasparini, Xin Lin, Jonathan A Javitch, Ramin V Parsey, Richard E Carson, Irina Esterlis
Positron emission tomography tracers [(11)C]ABP688 and [(18)F]FPEB target the metabotropic glutamate receptor subtype 5 providing quantification of the brain glutamatergic system in vivo. Previous [(11)C]ABP688 positron emission tomography human test-retest studies indicate that, when performed on the same day, significant binding increases are observed; however, little deviation is reported when scans are >7 days apart. Due to the small cohorts examined previously (eight and five males, respectively), we aimed to replicate the same-day test-retest studies in a larger cohort including both males and females...
October 14, 2016: Journal of Cerebral Blood Flow and Metabolism
Matthew J Murray, Hannah M Ogden, Carlos Toro, Qingnan Liu, Amy S Mullin
We report state-resolved collision dynamics for CO molecules prepared in an optical centrifuge and measured with high resolution transient IR absorption spectroscopy.Time-resolved polarization-sensitive measurements of excited CO molecules in the J=29 rotational state reveal that oriented angular momentum of CO rotors is relaxed by impulsive collisions.Translational energy gains for molecules in the initial plane of rotation are 3-fold larger than for randomized angular momentum orientations, indicating the presence of anisotropic kinetic energy...
October 6, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Lesley Evans Ogden
No abstract text is available yet for this article.
September 30, 2016: Science
Katherine M Flegal, Cynthia L Ogden
No abstract text is available yet for this article.
September 27, 2016: JAMA: the Journal of the American Medical Association
Max J Dörfel, Han Fang, Jonathan Crain, Michael Klingener, Jake Weiser, Gholson J Lyon
Naa10 is a N(α) -terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the α-amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40-50% of the human proteome is acetylated by Naa10, rendering this an enzyme with one of the most broad substrate ranges known. Recently, we reported an X-linked disorder of infancy, Ogden syndrome, in two families harboring a c.109 T > C (p.Ser37Pro) variant in NAA10. In the present study we performed in-depth characterization of a yeast model of Ogden syndrome...
September 26, 2016: Yeast
Adam Lustig, Michael Ogden, Robert W Brenner, Jerry Penso, Kimberly D Westrich, Robert W Dubois
BACKGROUND: In 2013, it was reported that about 1 of every 3 U.S. adults has hypertension. Of these 70 million individuals, approximately 50% have their blood pressure under control. Achieving hypertension control, especially in at-risk populations, requires a multipronged approach that includes lifestyle modifications and pharmacological treatment. As provider groups, hospital systems, and integrated delivery networks optimize their care processes to promote population health activities in support of the accountable care organization (ACO) model of care, managing hypertension and other chronic diseases will be essential to their success...
October 2016: Journal of Managed Care & Specialty Pharmacy
Cristina Ruscitto, Jane Ogden
OBJECTIVE: Jet lag is common place amongst long-haul cabin crew. Timed food has been shown to reset the circadian rhythm in rodents. Implementation intentions have been used to change eating behaviour. Mealtimes could therefore be used as a countermeasure to reduce jet lag and improve alertness in long-haul cabin crew through forming an implementation intention to improve the regularity of meals on days off. DESIGN: Sixty long-haul crew took part in a randomised controlled trial, with two conditions: forming an implementation intention to eat regular meals on days off vs...
October 14, 2016: Psychology & Health
Cécile Aenishaenslin, Catherine Bouchard, Jules K Koffi, Yann Pelcat, Nicholas H Ogden
Lyme disease (LD) is emerging in Canada. A key preventive strategy is promoting the adoption by the general public of personal preventive behaviors regarding tick bites. The aim of this study was to measure the changes in public awareness toward ticks and LD before and after the launch of a national communication campaign in Canada using data from two surveys conducted in March and December 2014. The results show a significant increase in awareness of LD after compared to before the campaign, but also suggest that the importance of this increase is not equal amongst Canadian regions...
October 2016: Ticks and Tick-borne Diseases
Denny Meyer, Jo-Anne Abbott, Imogen Rehm, Sunil Bhar, Azy Barak, Gary Deng, Klaire Wallace, Edward Ogden, Britt Klein
BACKGROUND: Suicidal patients often visit healthcare professionals in their last month before suicide, but medical practitioners are unlikely to raise the issue of suicide with patients because of time constraints and uncertainty regarding an appropriate approach. INTRODUCTION: A brief tool called the e-PASS Suicidal Ideation Detector (eSID) was developed for medical practitioners to help detect the presence of suicidal ideation (SI) in their clients. If SI is detected, the system alerts medical practitioners to address this issue with a client...
September 23, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Salima Gasmi, Nicholas H Ogden, Patrick A Leighton, L Robbin Lindsay, Karine Thivierge
Ixodes scapularis, the main vector of Borrelia burgdorferi, the spirochetal agent of Lyme disease, is expanding its range in southern Canada and bringing risk to the public from Lyme disease. The aims of this study were to (i) describe how risk of Lyme disease in Quebec, Canada, has changed from 2008 to 2014 by analysis of the number of tick submissions, the geographic scope of ticks submitted and the prevalence of B. burgdorferi in ticks removed from people and submitted through the Quebec passive tick surveillance program and (ii) explore whether exposure to ticks is influenced by age and sex...
October 2016: Ticks and Tick-borne Diseases
Letizia Palumbo, Ruth Ogden, Alexis D J Makin, Marco Bertamini
Repetitive prestimulation, in the form of click trains, is known to alter a wide range of cognitive and perceptual judgments. To date, no research has explored whether click trains also influence subjective preferences. This is plausible because preference is related to perceptual fluency and clicks may increase fluency, or, because preference is related to arousal and clicks may increase arousal. In Experiment 1, participants heard a click train, white noise, or silence through headphones and then saw an abstract symmetrical pattern on the screen for 0...
October 2015: I-Perception
Margaret A Ogden, Kristina W Rosbe, Jolie L Chang
PURPOSE OF REVIEW: Chronic sialadenitis can affect patients of all age ranges and typically presents as recurrent or chronic painful swelling of the salivary glands. In children, the most common cause of sialadenitis is juvenile recurrent parotitis. Salivary stones, or sialolithiasis, are a much less common cause. Historically, for patients with chronic sialadenitis who failed conservative management, salivary gland removal was the standard treatment option. Recently, however, sialendoscopy has emerged as an effective gland-preserving procedure for sialadenitis evaluation and treatment in adults and children...
September 15, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
Riley Edward Perszyk, John O DiRaddo, Katie L Strong, Chian-Ming Low, Kevin K Ogden, Alpa Khatri, Geoffrey A Vargish, Kenneth A Pelkey, Ludovic Tricoire, Dennis C Liotta, Yoland Smith, Chris J McBain, Stephen F Traynelis
NMDA receptors (NMDARs) are ionotropic glutamatergic receptors that have been implicated in learning, development, and neuropathological conditions. They are typically composed of GluN1 and GluN2A-D subunits. Whereas a great deal is known about the role of GluN2A- and GluN2B-containing NMDARs, much less is known about GluN2D-containing NMDARs. Here we explore the subunit composition of synaptic NMDARs on hippocampal interneurons. GluN2D mRNA was detected by single-cell PCR and in situ hybridization in diverse interneuron subtypes in the CA1 region of the hippocampus...
September 13, 2016: Molecular Pharmacology
Camilo Mejia, Josh Lewis, Clinton Jordan, Juan Mejia, Connor Ogden, Troy Monson, Duane Winden, Marc Watson, Paul R Reynolds, Juan A Arroyo
Cigarette smoke is known to be a risk for the development of intrauterine growth restriction (IUGR). Our objective was to assess the effects of secondhand smoke (SHS) during pregnancy and to what extent it regulates the activation of mTOR family members and murine trophoblast invasion. Mice were treated to SHS for 4 days. Placental and fetal weights were recorded at the time of necropsy. Immunohistochemistry was used to determine the level of placental trophoblast invasion. Western blots were utilized to assess the activation of caspase 3, XIAP, mTOR, p70 and 4EBP1 in treated and control placental lysates...
September 9, 2016: Cell and Tissue Research
Ashley Ralston, Patti Ogden, Michael H Kohrman, David M Frim
Vagus nerve stimulators (VNSs) are currently an accepted treatment for intractable epilepsy not amenable to ablative surgery. Battery death and lead damage are the main reasons for reoperation in patients with VNSs. In general, any damage to the lead requires revision surgery to remove the helical electrodes from the vagus nerve and replace the electrode array and wire. The electrodes are typically scarred and difficult to remove from the vagus nerve without injury. The authors describe 6 patients with VNSs who presented with low lead impedance on diagnostic testing, leading to the intraoperative finding of lead insulation disruption, or who were found incidentally at the time of implantable pulse generator battery replacement to have a tear in the outer insulation of the electrode wire...
September 9, 2016: Journal of Neurosurgery. Pediatrics
Hannah G Lawman, Cheryl D Fryar, Qiuping Gu, Cynthia L Ogden
OBJECTIVE: Previous research has not investigated the role of prescription medication in sleep-obesity associations despite the fact that 56% of U.S. adults take at least one prescription medication. METHODS: Data from n = 16,622 adults in the National Health and Nutrition Examination Survey (2007-2012) were used to examine how the association between obesity and self-reported sleep duration varied by total number of prescription medications used in the past 30 days and by select classes of prescription medications including anxiolytics/sedatives/hypnotics, antidepressants, sleep aids, anticonvulsants, thyroid agents, and metabolic agents...
October 2016: Obesity
Feiran Zhang, Christy Hammack, Sarah C Ogden, Yichen Cheng, Emily M Lee, Zhexing Wen, Xuyu Qian, Ha Nam Nguyen, Yujing Li, Bing Yao, Miao Xu, Tianlei Xu, Li Chen, Zhiqin Wang, Hao Feng, Wei-Kai Huang, Ki-Jun Yoon, Chao Shan, Luoxiu Huang, Zhaohui Qin, Kimberly M Christian, Pei-Yong Shi, Mingjiang Xu, Menghang Xia, Wei Zheng, Hao Wu, Hongjun Song, Hengli Tang, Guo-Li Ming, Peng Jin
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed to Asian ZIKV(C), African ZIKV(M), and dengue virus (DENV). In contrast to the robust global transcriptome changes induced by DENV, ZIKV has a more selective and larger impact on expression of genes involved in DNA replication and repair. While overall expression profiles are similar, ZIKV(C), but not ZIKV(M), induces upregulation of viral response genes and TP53...
October 14, 2016: Nucleic Acids Research
Miao Xu, Emily M Lee, Zhexing Wen, Yichen Cheng, Wei-Kai Huang, Xuyu Qian, Julia Tcw, Jennifer Kouznetsova, Sarah C Ogden, Christy Hammack, Fadi Jacob, Ha Nam Nguyen, Misha Itkin, Catherine Hanna, Paul Shinn, Chase Allen, Samuel G Michael, Anton Simeonov, Wenwei Huang, Kimberly M Christian, Alison Goate, Kristen J Brennand, Ruili Huang, Menghang Xia, Guo-Li Ming, Wei Zheng, Hongjun Song, Hengli Tang
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug candidates and pharmacologically active compounds; we identified compounds that either inhibit ZIKV infection or suppress infection-induced caspase-3 activity in different neural cells. A pan-caspase inhibitor, emricasan, inhibited ZIKV-induced increases in caspase-3 activity and protected human cortical neural progenitors in both monolayer and three-dimensional organoid cultures...
October 2016: Nature Medicine
Zachary E Brewer, William David Ogden, James I Fann, Thomas A Burdon, Ahmad Y Sheikh
Several modern learning frameworks (eg, cognitive apprenticeship, anchored instruction, and situated cognition) posit the utility of nontraditional methods for effective experiential learning. Thus, development of novel educational tools emphasizing the cognitive framework of operative sequences may be of benefit to surgical trainees. We propose the development and global deployment of an effective, mobile cognitive cardiac surgical simulator. In methods, 16 preclinical medical students were assessed. Overall, 4 separate surgical modules (sternotomy, cannulation, decannulation, and sternal closure) were created utilizing the Touch Surgery (London, UK) platform...
2016: Seminars in Thoracic and Cardiovascular Surgery
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