keyword
https://read.qxmd.com/read/38536879/comprehensive-mutagenesis-maps-the-effect-of-all-single-codon-mutations-in-the-aav2-rep-gene-on-aav-production
#1
JOURNAL ARTICLE
Nina K Jain, Pierce J Ogden, George M Church
Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult. The AAV Rep proteins, which are essential for genome replication and packaging, represent a promising engineering target for improvement of rAAV production but remain underexplored. To gain a comprehensive understanding of the Rep proteins and their mutational landscape, we assayed the effects of all 39,297 possible single-codon mutations to the AAV2 rep gene on AAV2 production...
March 27, 2024: ELife
https://read.qxmd.com/read/38523483/an-estimation-of-the-biomechanical-properties-of-the-continent-and-incontinent-woman-bladder-via-inverse-finite-element-analysis
#2
JOURNAL ARTICLE
Maria Elisabete Teixeira da Silva, Fábio André Teixeira Pinheiro, Nuno Miguel Ferreira, Fernanda Sofia Quintela da Silva Brandão, Pedro Alexandre Lopes de Sousa Martins, Marco Paulo Lages Parente, Maria Teresa da Quinta E Costa Mascarenhas Saraiva, António Augusto Fernandes, Renato Manuel Natal Jorge
Stress urinary incontinence often results from pelvic support structures' weakening or damage. This dysfunction is related to direct injury of the pelvic organ's muscular, ligamentous or connective tissue structures due to aging, vaginal delivery or increase of the intra-abdominal pressure, for example, defecation or due to obesity. Mechanical changes alter the soft tissues' microstructural composition and therefore may affect their biomechanical properties. This study focuses on adapting an inverse finite element analysis to estimate the in vivo bladder's biomechanical properties of two groups of women (continent group (G1) and incontinent group (G2))...
March 25, 2024: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://read.qxmd.com/read/38514445/comparison-of-clinical-efficacy-between-arthroscopic-and-open-surgery-for-ogden-type-1-2-peroneal-tendon-dislocation
#3
JOURNAL ARTICLE
Zhenyu Wang, Guo Zheng, Fangcheng Yang, Yuanqiang Li, Yang Liu, Xinyu Xie, Xu Tao
OBJECTIVE: While the incidence of peroneal tendon dislocation (PTD) is relatively low, it is frequently underdiagnosed in clinical practice, and the misdiagnosis or improper treatment of this condition may lead to a decline in patients' quality of life. Currently, the surgical treatment options for PTD mainly include open and arthroscopic surgery. However, in order to evaluate the advantages and disadvantages of these two surgical approaches, further comparative research is needed. Therefore, the aim of this study is to investigate the early clinical outcomes of arthroscopic and open surgery in the treatment of Ogden type 1-2 PTD...
March 21, 2024: Orthopaedic Surgery
https://read.qxmd.com/read/38509528/knowledge-protective-behaviours-and-perception-of-lyme-disease-in-an-area-of-emerging-risk-results-from-a-cross-sectional-survey-of-adults-in-ottawa-ontario
#4
JOURNAL ARTICLE
James J Logan, Michael Sawada, Anders Knudby, Tim Ramsay, Justine I Blanford, Nicholas H Ogden, Manisha A Kulkarni
BACKGROUND: The number of Lyme disease risk areas in Canada is growing. In regions with emerging tick populations, it is important to emphasize peridomestic risk and the importance of protective behaviours in local public health communication. This study aims to identify characteristics associated with high levels of Lyme disease knowledge and adoption of protective behaviours among residents in the Ottawa, Ontario region. METHODS: A geographically stratified web survey was conducted in November 2020 (n = 2018) to determine knowledge, attitudes, and practices regarding Lyme disease among adult residents...
March 20, 2024: BMC Public Health
https://read.qxmd.com/read/38496069/tobacco-free-nicotine-pouches-and-their-potential-contribution-to-tobacco-harm-reduction-a-scoping-review
#5
REVIEW
Erika Grandolfo, Henry Ogden, Ian M Fearon, Layla Malt, Matthew Stevenson, Sarah Weaver, Thomas Nahde
Tobacco harm reduction (THR) refers to strategies designed to reduce the health risks associated with tobacco smoking but may involve continued use of nicotine and/or tobacco. Next-generation products (NGPs) are a THR alternative as they do not burn tobacco or produce smoke and deliver nicotine and have fewer and substantially lower levels of harmful chemicals compared to cigarettes. Tobacco‑free nicotine pouches (TFNPs) are an emerging category of nicotine‑containing oral products that do not combust or contain tobacco leaf...
February 2024: Curēus
https://read.qxmd.com/read/38476094/functional-support-vector-machine
#6
JOURNAL ARTICLE
Shanghong Xie, R Todd Ogden
Linear and generalized linear scalar-on-function modeling have been commonly used to understand the relationship between a scalar response variable (e.g. continuous, binary outcomes) and functional predictors. Such techniques are sensitive to model misspecification when the relationship between the response variable and the functional predictors is complex. On the other hand, support vector machines (SVMs) are among the most robust prediction models but do not take account of the high correlations between repeated measurements and cannot be used for irregular data...
March 13, 2024: Biostatistics
https://read.qxmd.com/read/38440772/quantifying-the-economic-gains-associated-with-covid-19-vaccination-in-the-canadian-population-a-cost-benefit-analysis
#7
JOURNAL ARTICLE
Ashleigh R Tuite, Victoria Ng, Raphael Ximenes, Alan Diener, Ellen Rafferty, Nicholas H Ogden, Matthew Tunis
BACKGROUND: Vaccination has been a key part of Canada's coronavirus disease 2019 (COVID-19) pandemic response. Although the clinical benefits of vaccination are clear, an understanding of the population-level benefits of vaccination relative to the programmatic costs is of value. The objective of this article is to quantify the economic impact of COVID-19 vaccination in the Canadian population between December 2020 and March 2022. METHODS: We conducted a model-based cost-benefit analysis of Canada's COVID-19 vaccination program...
June 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38425666/immunoglobulin-replacement-therapies-in-inborn-errors-of-immunity-a-review
#8
REVIEW
Archan Sil, Suprit Basu, Vibhu Joshi, Rakesh Kumar Pilania, Sangeetha Siniah, Deepti Suri, Amit Rawat, Surjit Singh
Immunoglobulins (Ig) were used as a therapeutic modality for the first time in a patient with X-linked agammaglobulinemia in 1952 by Colonel Ogden Bruton, decades before the molecular mechanisms causing the disease were unraveled. In many autoimmune and inflammatory illnesses, human immunoglobulin has been employed as a significant immunomodulatory and immunosuppressive drug. In patients with inborn errors of immunity (IEI), immunoglobulin remains a cornerstone of management. IEIs are notable causes of recurrent infections and autoimmunity due to inheritable single-gene defects in genes encoding for different components of the immune system...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38422775/subject-specific-material-properties-of-the-heel-pad-an-inverse-finite-element-analysis
#9
JOURNAL ARTICLE
Vara Isvilanonda, Ellen Y Li, Evan D Williams, Peter R Cavanagh, David R Haynor, Baocheng Chu, William R Ledoux
Individuals with diabetes are at a higher risk of developing foot ulcers. To better understand internal soft tissue loading and potential treatment options, subject-specific finite element (FE) foot models have been used. However, existing models typically lack subject-specific soft tissue material properties and only utilize subject-specific anatomy. Therefore, this study determined subject-specific hindfoot soft tissue material properties from one non-diabetic and one diabetic subject using inverse FE analysis...
February 22, 2024: Journal of Biomechanics
https://read.qxmd.com/read/38415858/dr-terry-l-maple
#10
JOURNAL ARTICLE
Jacqueline Ogden
No abstract text is available yet for this article.
February 28, 2024: Zoo Biology
https://read.qxmd.com/read/38392322/evaluation-of-the-impact-of-population-management-on-the-genetic-parameters-of-selected-spiral-horned-antelopes
#11
JOURNAL ARTICLE
Ema Cetkovská, Karolína Brandlová, Rob Ogden, Barbora Černá Bolfíková
The rapid loss of biodiversity and the associated reduction and fragmentation of habitats means that ex situ populations have become an important part of species conservation. These populations, which are often established from a small number of founders, require careful management to avoid the negative effects of genetic drift and inbreeding. Although the inclusion of molecular data is recommended, their availability for captive breeding management remains limited. The aim of this study was to evaluate the relationship between the levels of genetic diversity in six spiral-horned antelope taxa bred under human care and their respective management strategies, conservation status, demography, and geographic origin, using 10 nuclear DNA microsatellite loci and mitochondrial control region DNA sequences...
February 7, 2024: Biology
https://read.qxmd.com/read/38391630/computational-study-of-abdominal-aortic-aneurysm-walls-accounting-for-patient-specific-non-uniform-intraluminal-thrombus-thickness-and-distinct-material-models-a-pre-and-post-rupture-case
#12
JOURNAL ARTICLE
Platon Sarantides, Anastasios Raptis, Dimitrios Mathioulakis, Konstantinos Moulakakis, John Kakisis, Christos Manopoulos
An intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms, playing a crucial role in their growth and rupture. Although most computational studies do not include the ILT, in the present study, this is taken into account, laying out the whole simulation procedure, namely, from computed tomography scans to medical image segmentation, geometry reconstruction, mesh generation, biomaterial modeling, finite element analysis, and post-processing, all carried out in open software. By processing the tomography scans of a patient's aneurysm before and after rupture, digital twins are reconstructed assuming a uniform aortic wall thickness...
January 31, 2024: Bioengineering
https://read.qxmd.com/read/38374660/-never-give-up-the-creator-has-good-things-in-store-for-you-risk-factors-protective-factors-and-evidence-of-resilience-for-canadian-indigenous-women-abused-by-intimate-partners
#13
JOURNAL ARTICLE
Cindy L Ogden, Leslie M Tutty
Canadian Indigenous women often experience severe partner violence and child abuse, but few studies holistically examine risk and protective factors and evidence of resilience that affect their well-being. This mixed-methods secondary analysis explored the experiences of 40 Canadian Indigenous abused women. Risk factors included intimate partner violence (IPV), childhood abuse, poverty, colonization, and disability. Protective factors included formal and informal support, community support, spirituality, and childhood residence...
February 19, 2024: Violence Against Women
https://read.qxmd.com/read/38371981/an-ogden-hyperelastic-3d-micromechanical-model-to-depict-poynting-effect-in-brain-white-matter
#14
JOURNAL ARTICLE
Mohit Agarwal, Assimina A Pelegri
Shear and torsional load on soft solids such as brain white matter purportedly exhibits the Poynting Effect. It is a typical nonlinear phenomenon associated with soft materials whereby they tend to elongate (positive Poynting effect) or contract (negative Poynting effect) in a direction perpendicular to the shearing or twisting plane. In this research, a novel 3D micromechanical Finite Element Model (FEM) has been formulated to describe the Poynting effect in bi-phasic modeled brain white matter (BWM) representative volume element (RVE) with axons tracts embedded in surrounding extracellular matrix (ECM) for simulating brain matter's response to pure and simple shear...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38352572/ophthalmic-manifestations-of-naa10-related-and-naa15-related-neurodevelopmental-syndrome-analysis-of-cortical-visual-impairment-and-refractive-errors
#15
Rahi Patel, Agnes Y Park, Elaine Marchi, Andrea L Gropman, Matthew T Whitehead, Gholson J Lyon
NAA10 -related and NAA15 -related neurodevelopmental syndrome, otherwise known as Ogden Syndrome, is known to present with varying degrees of intellectual disability, hypotonia, congenital cardiac abnormalities, seizures, and delayed speech and motor development. However, the ophthalmic manifestations of NAA10 and NAA15 mutations are not yet fully characterized or understood. This study analyzed the prevalence of six ophthalmic conditions (cortical visual impairment, myopia, hyperopia, strabismus, nystagmus, and astigmatism) in 67 patients with pathogenic mutations in the NAA10 cohort (54 inherited, 10 de novo; 65 missense, 2 frameshift) and 19 patients with pathogenic mutations in the NAA15 cohort (18 de novo; 8 frameshift, 4 missense, 4 nonsense, and 1 splice site)...
February 2, 2024: medRxiv
https://read.qxmd.com/read/38349724/estimating-the-incidence-and-economic-cost-of-lyme-disease-cases-in-canada-in-the-21st-century-with-projected-climate-change
#16
JOURNAL ARTICLE
Nicholas H Ogden, Ariane Dumas, Philippe Gachon, Ellen Rafferty
BACKGROUND: Lyme disease (LD) is emerging in Canada owing to the range expansion of the tick vector Ixodes scapularis ( I. scapularis ). OBJECTIVES: Our objective was to estimate future LD incidence in Canada, and economic costs, for the 21st century with projected climate change. METHODS: Future regions of climatic suitability for I. scapularis were projected from temperature output of the North American Coordinated Regional Climate Downscaling Experiment regional climate model ensemble using greenhouse gas Representative Concentration Pathways (RCPs) 4...
February 2024: Environmental Health Perspectives
https://read.qxmd.com/read/38345812/reasons-for-nonparticipation-in-the-special-supplemental-nutrition-program-for-women-infants-and-children
#17
JOURNAL ARTICLE
Ana L Terry, Edwina Wambogo, Kelley S Scanlon, Cheryl D Fryar, Melissa Abelev, Amanda Reat, Cynthia L Ogden
No abstract text is available yet for this article.
February 12, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38343084/strategies-used-for-childhood-chronic-functional-constipation-the-success-evidence-synthesis
#18
Alex Todhunter-Brown, Lorna Booth, Pauline Campbell, Brenda Cheer, Julie Cowie, Andrew Elders, Suzanne Hagen, Karen Jankulak, Helen Mason, Clare Millington, Margaret Ogden, Charlotte Paterson, Davina Richardson, Debs Smith, Jonathan Sutcliffe, Katie Thomson, Claire Torrens, Doreen McClurg
BACKGROUND: Up to 30% of children have constipation at some stage in their life. Although often short-lived, in one-third of children it progresses to chronic functional constipation, potentially with overflow incontinence. Optimal management strategies remain unclear. OBJECTIVE: To determine the most effective interventions, and combinations and sequences of interventions, for childhood chronic functional constipation, and understand how they can best be implemented...
January 2024: Health Technology Assessment: HTA
https://read.qxmd.com/read/38335407/naa10-gene-related-ogden-syndrome-with-obstructive-hypertrophic-cardiomyopathy-a-rare-case-report
#19
JOURNAL ARTICLE
Feihong Li, Wenyang Wang, Yazhou Li, Xiwang Liu, Zhirui Zhu, Jian Tang, Yaoqin Hu
RATIONALE: Ogden syndrome is an exceptionally rare X-linked disease caused by mutations in the NAA10 gene. Reported cases of this syndrome are approximately 20 children and are associated with facial dysmorphism, growth delay, developmental disorders, congenital heart disease, and arrhythmia. PATIENT CONCERNS: We present the clinical profile of a 3-year-old girl with Ogden syndrome carrying a de novo NAA10 variant [NM_003491:c.247C>T, p.(Arg83Cys)]. During infancy, she exhibited features such as left ventricular hypertrophy, protruding eyeballs, and facial deformities...
February 9, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38331966/a-framework-for-more-equitable-diverse-and-inclusive-patient-and-public-involvement-for-palliative-care-research
#20
JOURNAL ARTICLE
Sarah Mitchell, Nicola Turner, Kate Fryer, Jude Beng, Margaret E Ogden, Melanie Watson, Clare Gardiner, Joanne Bayly, Katherine E Sleeman, Catherine J Evans
BACKGROUND: There are marked inequalities in palliative care provision. Research is needed to understand how such inequalities can be addressed, so that everyone living with advanced illness can receive the care they need, when they need it. Research into inequalities in palliative care should be guided by Patient and Public Involvement (PPI) that includes people from diverse backgrounds, who are less likely to receive specialist services. Multi-disciplinary research partnerships, bringing together primary care (the main providers of palliative care to diverse communities) and specialist palliative care, have the potential to work together in new ways to do research to address inequalities and improve palliative care in practice...
February 8, 2024: Research Involvement and Engagement
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