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https://www.readbyqxmd.com/read/29229594/interim-results-of-brentuximab-vedotin-in-combination-with-nivolumab-in-patients-with-relapsed-or-refractory-hodgkin-lymphoma
#1
Alex F Herrera, Alison J Moskowitz, Nancy L Bartlett, Julie M Vose, Radhakrishnan Ramchandren, Tatyana A Feldman, Ann S LaCasce, Stephen M Ansell, Craig H Moskowitz, Keenan Fenton, Carol Anne Ogden, David Taft, Qu Zhang, Kazunobu Kato, Mary Campbell, Ranjana H Advani
In this phase 1/2 study, brentuximab vedotin (BV) and nivolumab (Nivo) administered in combination were evaluated as initial salvage therapy in patients with relapsed or refractory (R/R) classical Hodgkin lymphoma (HL) (ClinicalTrials.gov #NCT02572167). Patients received up to 4 cycles of combination treatment, with BV administered on Day 1 and Nivo on Day 8 of the first cycle. For Cycles 2-4, BV and Nivo were both administered on Day 1. Following study treatment, responses were evaluated by investigators per the 2014 Lugano classification, and patients could proceed to autologous stem cell transplantation (ASCT)...
December 11, 2017: Blood
https://www.readbyqxmd.com/read/29224869/effects-of-straw-processing-and-pen-overstocking-on-the-growth-performance-and-sorting-characteristics-of-diets-offered-to-replacement-holstein-dairy-heifers
#2
W K Coblentz, M S Akins, N M Esser, R K Ogden, S L Gelsinger
Our objectives were to evaluate the effects of pen-stocking density and straw processing on the growth performance, feed-bunk sorting behaviors, and hygiene of Holstein dairy heifers. Two corn silage-alfalfa haylage diets diluted with wheat straw were offered; diet composition was identical, except that one diet contained short (well-processed) straw (SS; 46.0% neutral detergent fiber, 12.9% crude protein, 60.7% total digestible nutrients, TDN), and the other long (poorly processed) straw (LS; 46.5% neutral detergent fiber, 12...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29220821/predictive-capabilities-of-various-constitutive-models-for-arterial-tissue
#3
Florian Schroeder, Stanislav Polzer, Martin Slažanský, Vojtěch Man, Pavel Skácel
INTRODUCTION: Aim of this study is to validate some constitutive models by assessing their capabilities in describing and predicting uniaxial and biaxial behavior of porcine aortic tissue. METHODS: 14 samples from porcine aortas were used to perform 2 uniaxial and 5 biaxial tensile tests. Transversal strains were furthermore stored for uniaxial data. The experimental data were fitted by four constitutive models: Holzapfel-Gasser-Ogden model (HGO), model based on generalized structure tensor (GST), Four-Fiber-Family model (FFF) and Microfiber model...
November 22, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29203457/non-invasive-estimation-of-11c-pbr28-binding-potential
#4
Martin Schain, Francesca Zanderigo, R Todd Ogden, William C Kreisl
[11C]PBR28 is a PET radioligand used to estimate densities of the 18 kDa translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood samples are required for full quantification. Here, we evaluate a methodology for full quantification of [11C]PBR28 PET data that does not require either a reference region or blood samples. Simultaneous estimation (SIME) uses time-activity curves from several brain regions to estimate binding potential (BPND), a theoretically more sensitive outcome measure than total distribution volume...
December 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/29199498/gpgpu-based-explicit-finite-element-computations-for-applications-in-biomechanics-the-performance-of-material-models-element-technologies-and-hardware-generations
#5
V Strbac, D M Pierce, J Vander Sloten, N Famaey
Finite element (FE) simulations are increasingly valuable in assessing and improving the performance of biomedical devices and procedures. Due to high computational demands such simulations may become difficult or even infeasible, especially when considering nearly incompressible and anisotropic material models prevalent in analyses of soft tissues. Implementations of GPGPU-based explicit FEs predominantly cover isotropic materials, e.g. the neo-Hookean model. To elucidate the computational expense of anisotropic materials, we implement the Gasser-Ogden-Holzapfel dispersed, fiber-reinforced model and compare solution times against the neo-Hookean model...
December 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29197751/dacron-graft-as-replacement-to-dissected-aorta-a-three-dimensional-fluid-structure-interaction-analysis
#6
R Jayendiran, B M Nour, A Ruimi
Aortic dissection (AD) is a serious medical condition characterized by a tear in the intima, the inner layer of the aortic walls. In such occurrence, blood is being diverted to the media (middle) layer and may result in patient death if not quickly attended. In the case where the diseased portion of the aorta needs to be replaced, one common surgical technique is to use a graft made of Dacron, a synthetic fabric. We investigate the response of a composite human aortic segment-Dacron graft structure subjected to blood flow using the three-dimensional fluid-structure-interaction (FSI) capability in Abaqus...
November 26, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29182546/luminescent-lanthanoid-calixarene-complexes-and-materials
#7
REVIEW
Massimiliano Massi, Mark I Ogden
This review aims to provide an overview of recent examples of lanthanoid-calixarene complexes incorporated into light-emitting materials. Background information on the antenna effect and early work on lanthanoid complexes on calixarenes is provided to set the context. Classes of materials discussed include polymers, nanoparticles, and metal clusters.
November 28, 2017: Materials
https://www.readbyqxmd.com/read/29179778/determining-requirements-for-patient-centred-care-a-participatory-concept-mapping-study
#8
Kathryn Ogden, Jennifer Barr, David Greenfield
BACKGROUND: Recognition of a need for patient-centred care is not new, however making patient-centred care a reality remains a challenge to organisations. We need empirical studies to extend current understandings, create new representations of the complexity of patient-centred care, and guide collective action toward patient-centred health care. To achieve these ends, the research aim was to empirically determine what organisational actions are required for patient-centred care to be achieved...
November 28, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29156355/biomechanical-evaluation-of-a-personalized-external-aortic-root-support-applied-in-the-ross-procedure
#9
Julie Vastmans, Heleen Fehervary, Peter Verbrugghe, Tom Verbelen, Emma Vanderveken, Jos Vander Sloten, Tom Treasure, Filip Rega, Nele Famaey
A commonly heard concern in the Ross procedure, where a diseased aortic valve is replaced by the patient's own pulmonary valve, is the possibility of pulmonary autograft dilatation. We performed a biomechanical investigation of the use of a personalized external aortic root support or exostent as a possibility for supporting the autograft. In ten sheep a short length of pulmonary artery was interposed in the descending aorta, serving as a simplified version of the Ross procedure. In seven of these cases, the autograft was supported by an external mesh or so-called exostent...
November 11, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29155689/prevalence-of-obesity-among-adults-and-youth-united-states-2015-2016
#10
Craig M Hales, Margaret D Carroll, Cheryl D Fryar, Cynthia L Ogden
Key findings Data from the National Health and Nutrition Examination Survey ● In 2015-2016, the prevalence of obesity was 39.8% in adults and 18.5% in youth. ● The prevalence of obesity was higher among middle-aged adults (42.8%) than among younger adults (35.7%). ● The prevalence of obesity was higher among youth aged 6-11 years (18.4%) and adolescents aged 12-19 years (20.6%) compared with children aged 2-5 years (13.9%). ● The overall prevalence of obesity was higher among non-Hispanic black and Hispanic adults than among non-Hispanic white and non-Hispanic Asian adults...
October 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/29152032/latent-class-modeling-using-matrix-covariates-with-application-to-identifying-early-placebo-responders-based-on-eeg-signals
#11
Bei Jiang, Eva Petkova, Thaddeus Tarpey, R Todd Ogden
Latent class models are widely used to identify unobserved subgroups (i.e., latent classes) based upon one or more manifest variables. The probability of belonging to each subgroup is typically modeled as a function of a set of measured covariates. In this paper, we extend existing latent class models to incorporate matrix covariates. This research is motivated by a randomized placebo-controlled depression clinical trial. One study goal is to identify a subgroup of subjects who experience symptoms improvement early on during antidepressant treatment, which is considered to be an indication of a placebo rather than a true pharmacological response...
September 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29138329/correction-for-avey-et-al-discovery-of-a-coregulatory-interaction-between-kaposi-s-sarcoma-associated-herpesvirus-orf45-and-the-viral-protein-kinase-orf36
#12
Denis Avey, Sarah Tepper, Benjamin Pifer, Amritpal Bahga, Hunter Williams, Joseph Gillen, Wenwei Li, Sarah Ogden, Fanxiu Zhu
No abstract text is available yet for this article.
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29133578/orlistat-induced-oxalate-nephropathy-an-under-recognised-cause-of-chronic-kidney-disease
#13
Laurence Richard Solomon, Andrew Christopher Nixon, Leanne Ogden, Beena Nair
Two patients developed kidney failure due to oxalate deposition in the kidney while taking orlistat. Cessation of orlistat was followed by partial recovery of kidney function. The mechanism by which orlistat causes hyperoxaluria and the management of orlistat-induced oxalate nephropathy is reviewed. We suggest that all patients taking orlistat are at risk of this condition, which may develop insidiously and is easily overlooked. Monitoring of kidney function of patients taking orlistat is warranted.
November 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29130113/long-term-results-of-closed-reduction-for-developmental-dislocation-of-the-hip-in-children-of-walking-age-under-eighteen-months-old
#14
Soo Min Cha, Hyun Dae Shin, Byung Kon Shin
BACKGROUND: Developmental dysplasia of the hip (DDH) diagnosed in older postnatal children can be effectively treated by closed reduction (CR) alone. However, no prospective or comparative trial to explore the differential effectiveness of CR between non-walking and walking postnatal children has yet been reported. This study investigated the clinical and radiologic outcomes of CR in the age range of interest (12-18 months old) via a prospective trial and compared these results with those of a younger age group who also underwent CR...
November 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29122737/the-effect-of-the-move-more-pack-on-the-physical-activity-of-cancer-survivors-protocol-for-a-randomized-waiting-list-control-trial-with-process-evaluation
#15
Justin Webb, Chris Fife-Schaw, Jane Ogden, Jo Foster
BACKGROUND: Physical activity can improve many common side effects of cancer treatment as well as improve physical function and quality of life (QOL). In addition, physical activity can improve survival rate and reduce cancer recurrence. Despite these benefits, only 23% of cancer survivors in England are active to recommended levels. Cancer survivors are interested in lifestyle behavior change. Home-based interventions offer a promising means for changing physical activity behavior. Prediagnosis levels of physical activity and self-efficacy have been reported to be predictors of physical activity behavior change...
November 9, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29111955/assessment-of-integration-of-disability-content-into-social-work-education
#16
Lydia Ogden, Carolyn McAllister, Susan Neely-Barnes
Three hundred members of the Council on Social Work Education (CSWE) responded to a survey regarding the inclusion of disability content in social work courses and supports needed to increase disability content. Although respondents generally agreed that disability content is important in social work education, its inclusion is inconsistent, with most frequent inclusion in courses on diversity and least frequent inclusion in courses on research. Respondents identified barriers to increasing disability content, including lack of resources for teaching, lack of relevant faculty expertise, and an over-crowded curriculum...
November 7, 2017: Journal of Social Work in Disability & Rehabilitation
https://www.readbyqxmd.com/read/29096122/effect-of-cryopreservation-at-80%C3%A2-c-on-visco-hyperelastic-properties-of-skeletal-muscle-tissue
#17
Naïm Jalal, Mustapha Zidi
This paper investigated the effect of cryopreservation at -80°C on mechanical visco-hyperelastic properties of skeletal muscle. For that, both tensile and compression relaxation tests were performed on porcine tissues samples in fibre and cross-fibre directions. Material parameters were identified by using first order Ogden's strain energy function coupled with second order Maxwell's model. The results revealed that the cryopreservation conditions at -80°C with conservative and cryoprotectant solution significantly affected the mechanical properties of the skeletal muscle...
October 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29093264/secreted-pla2-group-x-orchestrates-innate-and-adaptive-immune-responses-to-inhaled-allergen
#18
James D Nolin, Ying Lai, Herbert Luke Ogden, Anne M Manicone, Ryan C Murphy, Dowon An, Charles W Frevert, Farideh Ghomashchi, Gajendra S Naika, Michael H Gelb, Gail M Gauvreau, Adrian M Piliponsky, William A Altemeier, Teal S Hallstrand
Phospholipase A2 (PLA2) enzymes regulate the formation of eicosanoids and lysophospholipids that contribute to allergic airway inflammation. Secreted PLA2 group X (sPLA2-X) was recently found to be increased in the airways of asthmatics and is highly expressed in airway epithelial cells and macrophages. In the current study, we show that allergen exposure increases sPLA2-X in humans and in mice, and that global deletion of Pla2g10 results in a marked reduction in airway hyperresponsiveness (AHR), eosinophil and T cell trafficking to the airways, airway occlusion, generation of type-2 cytokines by antigen-stimulated leukocytes, and antigen-specific immunoglobulins...
November 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/29074579/phragmoplast-microtubule-dynamics-a-game-of-zones
#19
REVIEW
Andrei Smertenko, Seanna L Hewitt, Caitlin N Jacques, Rafal Kacprzyk, Yan Liu, Matthew J Marcec, Lindani Moyo, Aaron Ogden, Hui Min Oung, Sharol Schmidt, Erika A Serrano-Romero
Plant morphogenesis relies on the accurate positioning of the partition (cell plate) between dividing cells during cytokinesis. The cell plate is synthetized by a specialized structure called the phragmoplast, which consists of microtubules, actin filaments, membrane compartments and associated proteins. The phragmoplast forms between daughter nuclei during the transition from anaphase to telophase. As cells are commonly larger than the originally formed phragmoplast, the construction of the cell plate requires phragmoplast expansion...
October 26, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29074365/-snack-versus-meal-the-impact-of-label-and-place-on-food-intake
#20
Jane Ogden, Chloe Wood, Elise Payne, Hollie Fouracre, Frances Lammyman
Eating behaviour is influenced by both cognitions and triggers in the environment. The potential difference between a 'snack' and a 'meal' illustrates these factors and the way in which they interact, particularly in terms of the label used to describe food and the way it is presented. To date no research has specifically explored the independent and combined impact of label and presentation on eating behaviour. Using a preload/taste test design this experimental study evaluated the impact of label ('snack' vs...
January 1, 2018: Appetite
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