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https://www.readbyqxmd.com/read/29671475/integrated-social-behavioral-and-ecological-risk-maps-to-prioritize-local-public-health-responses-to-lyme-disease
#1
Catherine Bouchard, Cécile Aenishaenslin, Erin E Rees, Jules K Koffi, Yann Pelcat, Marion Ripoche, François Milord, L Robbin Lindsay, Nicholas H Ogden, Patrick A Leighton
BACKGROUND: The risk of contracting Lyme disease (LD) can vary spatially because of spatial heterogeneity in risk factors such as social-behavior and exposure to ecological risk factors. Integrating these risk factors to inform decision-making should therefore increase the effectiveness of mitigation interventions. OBJECTIVES: The objective of this study was to develop an integrated social-behavioral and ecological risk-mapping approach to identify priority areas for LD interventions...
April 18, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29665061/contracting-for-care-the-construction-of-the-farrier-role-in-supporting-horse-owners-to-prevent-laminitis
#2
J Lynden, J Ogden, T Hollands
BACKGROUND: Emerging research highlights how, due to demographic changes in horse owner populations in Western societies, complex owner-horse relationships are leading to inappropriate horse care, including over-nutrition, which in turn can lead to laminitis. Farriers, due to their regular visits, may be in a position to support owners in dealing with this problem. OBJECTIVES: This study explored whether UK farriers have a role in working with horse owners to support horse welfare and prevent laminitis...
April 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29662346/dc-dynamic-pull-in-instability-of-a-dielectric-elastomer-balloon-an-energy-based-approach
#3
Atul Kumar Sharma, Nitesh Arora, M M Joglekar
This paper reports an energy-based method for the dynamic pull-in instability analysis of a spherical dielectric elastomer (DE) balloon subjected to a quasi-statically applied inflation pressure and a Heaviside step voltage across the balloon wall. The proposed technique relies on establishing the energy balance at the point of maximum stretch in an oscillation cycle, followed by the imposition of an instability condition for extracting the threshold parameters. The material models of the Ogden family are employed for describing the hyperelasticity of the balloon...
March 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29662167/sequencing-of-prostate-cancers-identifies-new-cancer-genes-routes-of-progression-and-drug-targets
#4
David C Wedge, Gunes Gundem, Thomas Mitchell, Dan J Woodcock, Inigo Martincorena, Mohammed Ghori, Jorge Zamora, Adam Butler, Hayley Whitaker, Zsofia Kote-Jarai, Ludmil B Alexandrov, Peter Van Loo, Charlie E Massie, Stefan Dentro, Anne Y Warren, Clare Verrill, Dan M Berney, Nening Dennis, Sue Merson, Steve Hawkins, William Howat, Yong-Jie Lu, Adam Lambert, Jonathan Kay, Barbara Kremeyer, Katalin Karaszi, Hayley Luxton, Niedzica Camacho, Luke Marsden, Sandra Edwards, Lucy Matthews, Valeria Bo, Daniel Leongamornlert, Stuart McLaren, Anthony Ng, Yongwei Yu, Hongwei Zhang, Tokhir Dadaev, Sarah Thomas, Douglas F Easton, Mahbubl Ahmed, Elizabeth Bancroft, Cyril Fisher, Naomi Livni, David Nicol, Simon Tavaré, Pelvender Gill, Christopher Greenman, Vincent Khoo, Nicholas Van As, Pardeep Kumar, Christopher Ogden, Declan Cahill, Alan Thompson, Erik Mayer, Edward Rowe, Tim Dudderidge, Vincent Gnanapragasam, Nimish C Shah, Keiran Raine, David Jones, Andrew Menzies, Lucy Stebbings, Jon Teague, Steven Hazell, Cathy Corbishley, Johann de Bono, Gerhardt Attard, William Isaacs, Tapio Visakorpi, Michael Fraser, Paul C Boutros, Robert G Bristow, Paul Workman, Chris Sander, Freddie C Hamdy, Andrew Futreal, Ultan McDermott, Bissan Al-Lazikani, Andrew G Lynch, G Steven Bova, Christopher S Foster, Daniel S Brewer, David E Neal, Colin S Cooper, Rosalind A Eeles
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutations. Through the temporal dissection of aberrations, we identified driver mutations specifically associated with steps in the progression of prostate cancer, establishing, for example, loss of CHD1 and BRCA2 as early events in cancer development of ETS fusion-negative cancers...
April 16, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29626273/hyperelastic-mechanical-properties-of-ex-vivo-normal-and-intrauterine-growth-restricted-placenta
#5
Shier Nee Saw, Jess Yi Ru Low, May Han Huang Ong, Yu Wei Poh, Citra Nurfarah Zaini Mattar, Arijit Biswas, Choon Hwai Yap
Intrauterine Growth Restriction (IUGR) is a serious and prevalent pregnancy complication that is due to placental insufficiency and IUGR babies suffer significantly higher risks of mortality and morbidity. Current detection rate for IUGR is generally poor and thus an alternative diagnostic tool is needed to improve the IUGR detection. Elastography, a non-invasive method that measures the tissue stiffness, has been proposed as one such technique. However, to date, we have limited information on the mechanical properties of IUGR placenta...
April 6, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29584627/multi-scale-clustering-of-lyme-disease-risk-at-the-expanding-leading-edge-of-the-range-of-ixodes-scapularis-in-canada
#6
Marion Ripoche, Leslie Robbin Lindsay, Antoinette Ludwig, Nicholas H Ogden, Karine Thivierge, Patrick A Leighton
Since its detection in Canada in the early 1990s, Ixodes scapularis , the primary tick vector of Lyme disease in eastern North America, has continued to expand northward. Estimates of the tick's broad-scale distribution are useful for tracking the extent of the Lyme disease risk zone; however, tick distribution may vary widely within this zone. Here, we investigated I. scapularis nymph distribution at three spatial scales across the Lyme disease emergence zone in southern Quebec, Canada. We collected ticks and compared the nymph densities among different woodlands and different plots and transects within the same woodland...
March 27, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29580793/comparison-of-in-vivo-vs-ex-situ-obtained-material-properties-of-sheep-common-carotid-artery
#7
Marija Smoljkić, Peter Verbrugghe, Matilda Larsson, Erik Widman, Heleen Fehervary, Jan D'hooge, Jos Vander Sloten, Nele Famaey
Patient-specific biomechanical modelling can improve preoperative surgical planning. This requires patient-specific geometry as well as patient-specific material properties as input. The latter are, however, still quite challenging to estimate in vivo. This study focuses on the estimation of the mechanical properties of the arterial wall. Firstly, in vivo pressure, diameter and thickness of the arterial wall were acquired for sheep common carotid arteries. Next, the animals were sacrificed and the tissue was stored for mechanical testing...
March 23, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29580260/systematic-techniques-to-enhance-retention-in-randomised-controlled-trials-the-steer-study-protocol
#8
Katie Gillies, Peter Bower, Jim Elliott, Graeme MacLennan, Rumana S N Newlands, Margaret Ogden, Shaun P Treweek, Mary Wells, Miles D Witham, Bridget Young, Jill J Francis
BACKGROUND: Non-retention of participants seriously affects the credibility of clinical trial results and significantly reduces the potential of a trial to influence clinical practice. Non-retention can be defined as instances where participants leave the study prematurely. Examples include withdrawal of consent and loss to follow-up and thus outcome data cannot be obtained. The majority of existing interventions targeting retention fail to describe any theoretical basis for the observed improvement, or lack of improvement...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29570750/trends-in-obesity-and-severe-obesity-prevalence-in-us-youth-and-adults-by-sex-and-age-2007-2008-to-2015-2016
#9
Craig M Hales, Cheryl D Fryar, Margaret D Carroll, David S Freedman, Cynthia L Ogden
No abstract text is available yet for this article.
March 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29565748/high-resolution-ecological-niche-modeling-of-ixodes-scapularis-ticks-based-on-passive-surveillance-data-at-the-northern-frontier-of-lyme-disease-emergence-in-north-america
#10
Jean-Paul R Soucy, Andreea M Slatculescu, Christine Nyiraneza, Nicholas H Ogden, Patrick A Leighton, Jeremy T Kerr, Manisha A Kulkarni
BACKGROUND: Lyme disease (LD) is a bacterial infection transmitted by the black-legged tick (Ixodes scapularis) in eastern North America. It is an emerging disease in Canada due to the expanding range of its tick vector. Environmental risk maps for LD, based on the distribution of the black-legged tick, have focused on coarse determinants such as climate. However, climatic factors vary little within individual health units, the level at which local public health decision-making takes place...
March 22, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29558889/naa10-dysfunction-with-normal-nata-complex-activity-in-a-girl-with-non-syndromic-id-and-a-de-novo-naa10-p-v111g-variant-a-case-report
#11
Nina McTiernan, Svein Isungset Støve, Ingvild Aukrust, Marita Torrisen Mårli, Line M Myklebust, Gunnar Houge, Thomas Arnesen
BACKGROUND: The NAA10-NAA15 (NatA) protein complex is an N-terminal acetyltransferase responsible for acetylating ~ 40% of eukaryotic proteins. In recent years, NAA10 variants have been found in patients with an X-linked developmental disorder called Ogden syndrome in its most severe form and, in other familial or de novo cases, with variable degrees of syndromic intellectual disability (ID) affecting both sexes. CASE PRESENTATION: Here we report and functionally characterize a novel and de novo NAA10 (NM_003491...
March 20, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29550938/in-vivo-relationship-between-serotonin-1a-receptor-binding-and-gray-matter-volume-in-the-healthy-brain-and-in-major-depressive-disorder
#12
Francesca Zanderigo, Spiro Pantazatos, Harry Rubin-Falcone, R Todd Ogden, Binod Thapa Chhetry, Gregory Sullivan, Maria Oquendo, Jeffrey M Miller, J John Mann
Serotonin 1A (5-HT1A ) receptors mediate serotonin trophic role in brain neurogenesis. Gray matter volume (GMV) loss and 5-HT1A receptor binding alterations have been identified in major depressive disorder (MDD). Here we investigated the relationship between 5-HT1A receptor binding and GMV in 40 healthy controls (HCs) and, for the first time, 47 antidepressant-free MDD patients using Voxel-Based Morphometry and [11 C]WAY100635 Positron Emission Tomography. Values of GMV and 5-HT1A binding (expressed as BPF , one of the types of binding potentials that refer to displaceable or specific binding that can be quantified in vivo with PET) were obtained in 13 regions of interest, including raphe, and at the voxel level...
March 17, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29522180/passive-tick-surveillance-provides-an-accurate-early-signal-of-emerging-lyme-disease-risk-and-human-cases-in-southern-canada
#13
Marion Ripoche, Salima Gasmi, Ariane Adam-Poupart, Jules K Koffi, L Robbin Lindsay, Antoinette Ludwig, François Milord, Nicholas H Ogden, Karine Thivierge, Patrick A Leighton
Lyme disease is an emerging public health threat in Canada. In this context, rapid detection of new risk areas is essential for timely application of prevention and control measures. In Canada, information on Lyme disease risk is collected through three surveillance activities: active tick surveillance, passive tick surveillance, and reported human cases. However, each method has shortcomings that limit its ability to rapidly and reliably identify new risk areas. We investigated the relationships between risk signals provided by human cases, passive and active tick surveillance to assess the performance of tick surveillance for early detection of emerging risk areas...
March 7, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29510743/review-of-ecology-and-prevention-of-lyme-borreliosis-edited-by-marieta-a-h-braks-sipke-e-van-wieren-willem-takken-and-hein-sprong
#14
Nicholas H Ogden
Marieta AH Braks, Sipke E van Wieren, Willem Takken and Hein Sprong, EditorsEcology and prevention of Lyme borreliosis. In: Ecology and control of vector-borne diseases Volume 4Wageningen: Wageningen Academic Publishers; 2016.462 pages, ISBN 1875-0699.
March 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29496460/performance-and-precision-of-double-digestion-rad-ddrad-genotyping-in-large-multiplexed-datasets-of-marine-fish-species
#15
F Maroso, J E J Hillen, B G Pardo, K Gkagkavouzis, I Coscia, M Hermida, R Franch, B Hellemans, J Van Houdt, B Simionati, J B Taggart, E E Nielsen, G Maes, S A Ciavaglia, L M I Webster, F A M Volckaert, P Martinez, L Bargelloni, R Ogden
The development of Genotyping-By-Sequencing (GBS) technologies enables cost-effective analysis of large numbers of Single Nucleotide Polymorphisms (SNPs), especially in "non-model" species. Nevertheless, as such technologies enter a mature phase, biases and errors inherent to GBS are becoming evident. Here, we evaluated the performance of double digest Restriction enzyme Associated DNA (ddRAD) sequencing in SNP genotyping studies including high number of samples. Datasets of sequence data were generated from three marine teleost species (>5500 samples, >2...
February 27, 2018: Marine Genomics
https://www.readbyqxmd.com/read/29495796/importance-of-rotational-adiabaticity-in-collisions-of-co-2-super-rotors-with-ar-and-he
#16
Matthew J Murray, Hannah M Ogden, Amy S Mullin
The collision dynamics of optically centrifuged CO2 with Ar and He are reported here. The optical centrifuge produces an ensemble of CO2 molecules in high rotational states (with J ∼ 220) with oriented angular momentum. Polarization-dependent high-resolution transient IR absorption spectroscopy was used to measure the relaxation dynamics in the presence of Ar or He by probing the CO2 J = 76 and 100 states with Erot =2306 and 3979 cm-1 , respectively. The data show that He relaxes the CO2 super rotors more quickly than Ar...
February 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29486007/a-field-based-indicator-for-determining-the-likelihood-of-ixodes-scapularis-establishment-at-sites-in-ontario-canada
#17
Katie M Clow, Nicholas H Ogden, L Robbin Lindsay, Curtis B Russell, Pascal Michel, David L Pearl, Claire M Jardine
The emergence of the vector Ixodes scapularis in Ontario, Canada poses a significant public health risk. Both passive and active surveillance approaches have been employed by public health professionals (i.e., government employees) to monitor for the range expansion of this tick. Field surveillance using drag sampling for questing ticks is a recognized and effective method to identify reproducing tick populations. The degree of effort (i.e., number of visits per site) can enhance the sensitivity and specificity of surveillance, but increased effort conflicts with the cost to public health for field surveillance...
2018: PloS One
https://www.readbyqxmd.com/read/29479659/in-vivo-estimation-of-passive-biomechanical-properties-of-human-myocardium
#18
Arnab Palit, Sunil K Bhudia, Theodoros N Arvanitis, Glen A Turley, Mark A Williams
Identification of in vivo passive biomechanical properties of healthy human myocardium from regular clinical data is essential for subject-specific modelling of left ventricle (LV). In this work, myocardium was defined by Holzapfel-Ogden constitutive law. Therefore, the objectives of the study were (a) to estimate the ranges of the constitutive parameters for healthy human myocardium using non-invasive routine clinical data, and (b) to investigate the effect of geometry, LV end-diastolic pressure (EDP) and fibre orientations on estimated values...
February 26, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29468037/single-nucleotide-polymorphism-discovery-and-panel-characterization-in-the-african-forest-elephant
#19
Stéphanie Bourgeois, Helen Senn, Jenny Kaden, John B Taggart, Rob Ogden, Kathryn J Jeffery, Nils Bunnefeld, Katharine Abernethy, Ross McEwing
The continuing decline in forest elephant ( Loxodonta cyclotis ) numbers due to poaching and habitat reduction is driving the search for new tools to inform management and conservation. For dense rainforest species, basic ecological data on populations and threats can be challenging and expensive to collect, impeding conservation action in the field. As such, genetic monitoring is being increasingly implemented to complement or replace more burdensome field techniques. Single-nucleotide polymorphisms (SNPs) are particularly cost-effective and informative markers that can be used for a range of practical applications, including population census, assessment of human impact on social and genetic structure, and investigation of the illegal wildlife trade...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29455039/comparison-of-different-constitutive-models-to-characterize-the-viscoelastic-properties-of-human-abdominal-adipose-tissue-a-pilot-study
#20
Jose L Calvo-Gallego, Jaime Domínguez, Tomás Gómez Cía, Gorka Gómez Ciriza, Javier Martínez-Reina
Knowing the mechanical properties of human adipose tissue is key to simulate surgeries such as liposuction, mammoplasty and many plastic surgeries in which the subcutaneous fat is present. One of the most important surgeries, for its incidence, is the breast reconstruction surgery that follows a mastectomy. In this case, achieving a deformed shape similar to the healthy breast is crucial. The reconstruction is most commonly made using autologous tissue, taken from the patient's abdomen. The amount of autologous tissue and its mechanical properties have a strong influence on the shape of the reconstructed breast...
February 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
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