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https://www.readbyqxmd.com/read/28346992/longitudinal-assessment-of-hydropeaking-impacts-on-various-scales-for-an-improved-process-understanding-and-the-design-of-mitigation-measures
#1
C Hauer, P Holzapfel, P Leitner, W Graf
Hydropeaking is one of the main pressures on the aquatic ecology in alpine rivers. Beside studies on abiotic process and biotic response on the local scale there is a lack in process understanding on the reach scale. Especially longitudinal changes of hydropeaking impacts based on retention processes have not been studied yet. Thus, based on unsteady one-dimensional and two-dimensional depth averaged modelling it was targeted to investigate possible changes in vertical ramping velocity for the discussion of possible mitigation measures at the local scale...
January 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28253234/engineering-a-humanized-bone-organ-model-in-mice-to-study-bone-metastases
#2
Laure C Martine, Boris M Holzapfel, Jacqui A McGovern, Ferdinand Wagner, Verena M Quent, Parisa Hesami, Felix M Wunner, Cedryck Vaquette, Elena M De-Juan-Pardo, Toby D Brown, Bianca Nowlan, Dan Jing Wu, Cosmo Orlando Hutmacher, Davide Moi, Tatiana Oussenko, Elia Piccinini, Peter W Zandstra, Roberta Mazzieri, Jean-Pierre Lévesque, Paul D Dalton, Anna V Taubenberger, Dietmar W Hutmacher
Current in vivo models for investigating human primary bone tumors and cancer metastasis to the bone rely on the injection of human cancer cells into the mouse skeleton. This approach does not mimic species-specific mechanisms occurring in human diseases and may preclude successful clinical translation. We have developed a protocol to engineer humanized bone within immunodeficient hosts, which can be adapted to study the interactions between human cancer cells and a humanized bone microenvironment in vivo. A researcher trained in the principles of tissue engineering will be able to execute the protocol and yield study results within 4-6 months...
April 2017: Nature Protocols
https://www.readbyqxmd.com/read/28220831/the-distribution-of-the-apparent-diffusion-coefficient-as-an-indicator-of-the-response-to-chemotherapeutics-in-ovarian-tumour-xenografts
#3
Monique C Tourell, Ali Shokoohmand, Marietta Landgraf, Nina P Holzapfel, Patrina S P Poh, Daniela Loessner, Konstantin I Momot
Diffusion-weighted magnetic resonance imaging (DW-MRI) was used to evaluate the effects of single-agent and combination treatment regimens in a spheroid-based animal model of ovarian cancer. Ovarian tumour xenografts grown in non-obese diabetic/severe-combined-immunodeficiency (NOD/SCID) mice were treated with carboplatin or paclitaxel, or combination carboplatin/paclitaxel chemotherapy regimens. After 4 weeks of treatment, tumours were extracted and underwent DW-MRI, mechanical testing, immunohistochemical and gene expression analyses...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28187257/optical-fluorescence-detected-from-x-ray-irradiated-liquid-water
#4
Andreas Hans, Christian Ozga, Robert Seidel, Philipp Schmidt, Timo Ueltzhöffer, Xaver Holzapfel, Philip Wenzel, Philipp Reiß, Marvin N Pohl, Isaak Unger, Emad F Aziz, Arno Ehresmann, Petr Slavíček, Bernd Winter, André Knie
Despite its importance, the structure and dynamics of liquid water are still poorly understood in many apsects. Here, we report on the observation of optical fluorescence upon soft X-ray irradiation of liquid water. Detection of spectrally resolved fluorescence was achieved by a combination of the liquid microjet technique and fluorescence spectroscopy. We observe a genuine liquid-phase fluorescence manifested by a broad emission band in the 170-340 nm (4-7 eV) photon wavelength range. In addition, another narrower emission near 300 nm can be assigned to the fluorescence of OH (A state) in the gas phase, the emitting species being formed by Auger electrons escaping from liquid water...
March 1, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28168418/-acetabular-revision-arthroplasty-current-concepts-and-new-developments
#5
EDITORIAL
B M Holzapfel, M Rudert
No abstract text is available yet for this article.
February 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28144717/-individualized-unicondylar-knee-replacement-use-of-patient-specific-implants-and-instruments
#6
J Arnholdt, B M Holzapfel, L Sefrin, M Rudert, J Beckmann, A F Steinert
OBJECTIVE: Unicompartmental knee replacement in patients with osteoarthritis (OA) of the medial compartment. Individualized instruments and implants with a planning protocol for optimal fit. The individualized instruments and implants (ConforMIS Inc.; Burlington, MA, USA) are manufactured based on a computed tomography scan of the affected lower extremity and are provided together with a planning protocol (iView®) of the surgery. INDICATIONS: Unicompartmental OA of the knee (Kellgren & Lawrence stage IV) or Morbus Ahlbäck after unsuccessful conservative or joint preserving surgery...
February 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28144716/bicompartmental-individualized-knee-replacement-use-of-patient-specific-implants-and-instruments-iduo%C3%A2
#7
A F Steinert, J Beckmann, B M Holzapfel, M Rudert, J Arnholdt
OBJECTIVE: Bicompartmental knee replacement in patients with combined osteoarthritis (OA) of the medial or lateral and patellofemoral compartment. Patient-specific instruments and implants (ConforMIS iDuo™) with a planning protocol for optimal implant fit. INDICATIONS: Bicompartmental OA of the knee (Kellgren & Lawrence stage IV) affecting both the medial or lateral and patellofemoral compartment after unsuccessful conservative or joint-preserving surgery. CONTRAINDICATIONS: Tricompartmental OA, knee ligament instabilities, knee deformities >15° (varus, valgus, extension deficit)...
February 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28115257/higher-order-structures-in-purine-and-pyrimidine-metabolism
#8
REVIEW
Iva Chitrakar, Deborah M Kim-Holzapfel, Weijie Zhou, Jarrod B French
The recent discovery of several forms of higher order protein structures in cells has shifted the paradigm of how we think about protein organization and metabolic regulation. These dynamic and controllable protein assemblies, which are composed of dozens or hundreds of copies of an enzyme or related enzymes, have emerged as important players in myriad cellular processes. We are only beginning to appreciate the breadth of function of these types of macromolecular assemblies. These higher order structures, which can be assembled in response to varied cellular stimuli including changing metabolite concentrations or signaling cascades, give the cell the capacity to modulate levels of biomolecules both temporally and spatially...
March 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28092776/periosteum-tissue-engineering-in-an-orthotopic-in%C3%A2-vivo-platform
#9
J G Baldwin, F Wagner, L C Martine, B M Holzapfel, C Theodoropoulos, O Bas, F M Savi, C Werner, E M De-Juan-Pardo, D W Hutmacher
The periosteum plays a critical role in bone homeostasis and regeneration. It contains a vascular component that provides vital blood supply to the cortical bone and an osteogenic niche that acts as a source of bone-forming cells. Periosteal grafts have shown promise in the regeneration of critical size defects, however their limited availability restricts their widespread clinical application. Only a small number of tissue-engineered periosteum constructs (TEPCs) have been reported in the literature. A current challenge in the development of appropriate TEPCs is a lack of pre-clinical models in which they can reliably be evaluated...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28079117/high-field-transport-properties-of-a-p-doped-bafe2as2-film-on-technical-substrate
#10
Kazumasa Iida, Hikaru Sato, Chiara Tarantini, Jens Hänisch, Jan Jaroszynski, Hidenori Hiramatsu, Bernhard Holzapfel, Hideo Hosono
High temperature (high-Tc) superconductors like cuprates have superior critical current properties in magnetic fields over other superconductors. However, superconducting wires for high-field-magnet applications are still dominated by low-Tc Nb3Sn due probably to cost and processing issues. The recent discovery of a second class of high-Tc materials, Fe-based superconductors, may provide another option for high-field-magnet wires. In particular, AEFe2As2 (AE: Alkali earth elements, AE-122) is one of the best candidates for high-field-magnet applications because of its high upper critical field, Hc2, moderate Hc2 anisotropy, and intermediate Tc...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078371/acetabular-defect-classification-in-times-of-3d-imaging-and-patient-specific-treatment-protocols
#11
K Horas, J Arnholdt, A F Steinert, M Hoberg, M Rudert, B M Holzapfel
Parallel to the rising number of revision hip procedures, an increasing number of complex periprosthetic osseous defects can be expected. Stable long-term fixation of the revision implant remains the ultimate goal of the surgical protocol. Within this context, an elaborate preoperative planning process including anticipation of the periacetabular defect form and size and analysis of the remaining supporting osseous elements are essential. However, detection and evaluation of periacetabular bone defects using an unsystematic analysis of plain anteroposterior radiographs of the pelvis is in many cases difficult...
February 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28012061/-treatment-of-acetabular-bone-defects-in-revision-hip-arthroplasty-using-the-revisio-system
#12
M Hoberg, B M Holzapfel, A F Steinert, F Kratzer, M Walcher, M Rudert
BACKGROUND: Many different systems for the management of primary and secondary acetabular defects are available, each with its inherent advantages and disadvantages. The Revisio-System is a press-fit oval mono-block implant that makes a defect-oriented reconstruction and restoration of the center of rotation possible. MATERIAL AND METHODS: In this study, we retrospectively reviewed the outcome of 92 consecutive patients treated with this oval press-fit cup due to periacetabular bone loss...
February 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28009216/constraints-on-ultrahigh-energy-cosmic-ray-sources-from-a-search-for-neutrinos-above-10%C3%A2-pev-with-icecube
#13
M G Aartsen, K Abraham, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, M Archinger, C Argüelles, J Auffenberg, S Axani, X Bai, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, M Bissok, E Blaufuss, S Blot, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Braun, L Brayeur, H-P Bretz, A Burgman, T Carver, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, R Cross, M Day, J P A M de André, C De Clercq, E Del Pino Rosendo, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, P Eller, S Euler, P A Evenson, S Fahey, A R Fazely, J Feintzeig, J Felde, K Filimonov, C Finley, S Flis, C-C Fösig, A Franckowiak, E Friedman, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, K Ghorbani, W Giang, L Gladstone, M Glagla, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, D Grant, Z Griffith, C Haack, A Haj Ismail, A Hallgren, F Halzen, E Hansen, B Hansmann, T Hansmann, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, K Holzapfel, K Hoshina, F Huang, M Huber, K Hultqvist, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, M Jurkovic, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, J Kemp, A Kheirandish, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, R Konietz, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, C Krüger, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, M Labare, J L Lanfranchi, M J Larson, F Lauber, D Lennarz, M Lesiak-Bzdak, M Leuermann, J Leuner, L Lu, J Lünemann, J Madsen, G Maggi, K B M Mahn, S Mancina, M Mandelartz, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, A Meli, T Menne, G Merino, T Meures, S Miarecki, L Mohrmann, T Montaruli, M Moulai, R Nahnhauer, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, Ö Penek, J A Pepper, C Pérez de Los Heros, D Pieloth, E Pinat, P B Price, G T Przybylski, M Quinnan, C Raab, L Rädel, M Rameez, K Rawlins, R Reimann, B Relethford, M Relich, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, L Sabbatini, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, K Satalecka, M Schimp, P Schlunder, T Schmidt, S Schoenen, S Schöneberg, L Schumacher, D Seckel, S Seunarine, D Soldin, M Song, G M Spiczak, C Spiering, M Stahlberg, T Stanev, A Stasik, A Steuer, T Stezelberger, R G Stokstad, A Stößl, R Ström, N L Strotjohann, G W Sullivan, M Sutherland, H Taavola, I Taboada, J Tatar, F Tenholt, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, A Turcati, E Unger, M Usner, J Vandenbroucke, N van Eijndhoven, S Vanheule, M van Rossem, J van Santen, J Veenkamp, M Vehring, M Voge, M Vraeghe, C Walck, A Wallace, M Wallraff, N Wandkowsky, Ch Weaver, M J Weiss, C Wendt, S Westerhoff, B J Whelan, S Wickmann, K Wiebe, C H Wiebusch, L Wille, D R Williams, L Wills, M Wolf, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, M Zoll
We report constraints on the sources of ultrahigh-energy cosmic rays (UHECRs) above 10^{9}  GeV, based on an analysis of seven years of IceCube data. This analysis efficiently selects very high- energy neutrino-induced events which have deposited energies from 5×10^{5}  GeV to above 10^{11}  GeV. Two neutrino-induced events with an estimated deposited energy of (2.6±0.3)×10^{6}  GeV, the highest neutrino energy observed so far, and (7.7±2.0)×10^{5}  GeV were detected. The atmospheric background-only hypothesis of detecting these events is rejected at 3...
December 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27989920/mechanical-characterization-of-human-brain-tissue
#14
S Budday, G Sommer, C Birkl, C Langkammer, J Haybaeck, J Kohnert, M Bauer, F Paulsen, P Steinmann, E Kuhl, G A Holzapfel
Mechanics are increasingly recognized to play an important role in modulating brain form and function. Computational simulations are a powerful tool to predict the mechanical behavior of the human brain in health and disease. The success of these simulations depends critically on the underlying constitutive model and on the reliable identification of its material parameters. Thus, there is an urgent need to thoroughly characterize the mechanical behavior of brain tissue and to identify mathematical models that capture the tissue response under arbitrary loading conditions...
October 27, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27979319/three-versus-six-cycles-of-adjuvant-platinum-based-chemotherapy-in-early-stage-clear-cell-ovarian-carcinoma-a-multi-institutional-cohort
#15
Emily N Prendergast, Marie Holzapfel, Jennifer J Mueller, Mario M Leitao, Camille C Gunderson, Kathleen N Moore, Britt K Erickson, Charles A Leath, Elena S Diaz Moore, Joshua G Cohen, Christine S Walsh
OBJECTIVES: To determine if 6 versus 3cycles of adjuvant platinum-based chemotherapy with or without taxane impacts survival in early stage ovarian clear cell carcinoma (OCCC). METHODS: We retrospectively identified all cases of stage I and II OCCC treated at 5 institutions from January 1994 through December 2011. Patients were divided into 2 groups: those who received 3 versus 6cycles of adjuvant chemotherapy. Our cohort consisted of 210 patients with stage IA-II disease, 116 of whom underwent full surgical staging...
December 12, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27943050/in-vitro-evaluation-of-beneficial-properties-of-bacteriocinogenic-lactobacillus-plantarum-st8sh
#16
Svetoslav Dimitrov Todorov, Wilhelm Holzapfel, Luis Augusto Nero
Lactobacillus plantarum ST8Sh, isolated from Bulgarian salami "shpek" and previously characterized as bacteriocin producer, was evaluated for its beneficial properties. Based on the PCR analysis, Lb. plantarum ST8Sh was shown to host a gene related to the production of adhesion proteins such as Mab, Mub, EF, and PrgB. Genetic and physiological tests suggest Lb. plantarum ST8Sh to represent a potential probiotic candidate, including survival in the presence of low levels of pH and high levels of ox bile, production of β-galactosidase, bile salt deconjugation, high level of hydrophobicity, functional auto- and co-aggregation properties, and adhesion to cell lines...
December 10, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27913369/adaptive-optimal-control-using-frequency-selective-information-of-the-system-uncertainty-with-application-to-unmanned-aircraft
#17
Arnab Maity, Leonhard Hocht, Christian Heise, Florian Holzapfel
A new efficient adaptive optimal control approach is presented in this paper based on the indirect model reference adaptive control (MRAC) architecture for improvement of adaptation and tracking performance of the uncertain system. The system accounts here for both matched and unmatched unknown uncertainties that can act as plant as well as input effectiveness failures or damages. For adaptation of the unknown parameters of these uncertainties, the frequency selective learning approach is used. Its idea is to compute a filtered expression of the system uncertainty using multiple filters based on online instantaneous information, which is used for augmentation of the update law...
November 28, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27905419/drug-response-consistency-in-ccle-and-cgp
#18
Mehdi Bouhaddou, Matthew S DiStefano, Eric A Riesel, Emilce Carrasco, Hadassa Y Holzapfel, DeAnalisa C Jones, Gregory R Smith, Alan D Stern, Sulaiman S Somani, T Victoria Thompson, Marc R Birtwistle
No abstract text is available yet for this article.
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27903785/microstructure-and-mechanics-of-healthy-and-aneurysmatic-abdominal-aortas-experimental-analysis-and-modelling
#19
Justyna A Niestrawska, Christian Viertler, Peter Regitnig, Tina U Cohnert, Gerhard Sommer, Gerhard A Holzapfel
Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled by a ground matrix and embedded families of collagen fibres. Changes in the structural components of aortic walls such as the ground matrix and the embedded families of collagen fibres have been shown to play a significant role in the pathogenesis of aortic degeneration. Hence, there is a need to develop a deeper understanding of the microstructure and the related mechanics of aortic walls. In this study, tissue samples from 17 human abdominal aortas (AA) and from 11 abdominal aortic aneurysms (AAA) are systematically analysed and compared with respect to their structural and mechanical differences...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27868162/the-choice-of-a-constitutive-formulation-for-modeling-limb-flexion-induced-deformations-and-stresses-in-the-human-femoropopliteal-arteries-of-different-ages
#20
Anastasia Desyatova, Jason MacTaggart, William Poulson, Paul Deegan, Carol Lomneth, Anjali Sandip, Alexey Kamenskiy
Open and endovascular treatments for peripheral arterial disease are notorious for high failure rates. Severe mechanical deformations experienced by the femoropopliteal artery (FPA) during limb flexion and interactions between the artery and repair materials play important roles and may contribute to poor clinical outcomes. Computational modeling can help optimize FPA repair, but these simulations heavily depend on the choice of constitutive model describing the arterial behavior. In this study finite element model of the FPA in the standing (straight) and gardening (acutely bent) postures was built using computed tomography data, longitudinal pre-stretch and biaxially determined mechanical properties...
November 21, 2016: Biomechanics and Modeling in Mechanobiology
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