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https://www.readbyqxmd.com/read/27905419/drug-response-consistency-in-ccle-and-cgp
#1
Mehdi Bouhaddou, Matthew S DiStefano, Eric A Riesel, Emilce Carrasco, Hadassa Y Holzapfel, DeAnalisa C Jones, Gregory R Smith, Alan D Stern, Sulaiman S Somani, T Victoria Thompson, Marc R Birtwistle
No abstract text is available yet for this article.
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27903785/microstructure-and-mechanics-of-healthy-and-aneurysmatic-abdominal-aortas-experimental-analysis-and-modelling
#2
Justyna A Niestrawska, Christian Viertler, Peter Regitnig, Tina U Cohnert, Gerhard Sommer, Gerhard A Holzapfel
Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled by a ground matrix and embedded families of collagen fibres. Changes in the structural components of aortic walls such as the ground matrix and the embedded families of collagen fibres have been shown to play a significant role in the pathogenesis of aortic degeneration. Hence, there is a need to develop a deeper understanding of the microstructure and the related mechanics of aortic walls. In this study, tissue samples from 17 human abdominal aortas (AA) and from 11 abdominal aortic aneurysms (AAA) are systematically analysed and compared with respect to their structural and mechanical differences...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27868162/the-choice-of-a-constitutive-formulation-for-modeling-limb-flexion-induced-deformations-and-stresses-in-the-human-femoropopliteal-arteries-of-different-ages
#3
Anastasia Desyatova, Jason MacTaggart, William Poulson, Paul Deegan, Carol Lomneth, Anjali Sandip, Alexey Kamenskiy
Open and endovascular treatments for peripheral arterial disease are notorious for high failure rates. Severe mechanical deformations experienced by the femoropopliteal artery (FPA) during limb flexion and interactions between the artery and repair materials play important roles and may contribute to poor clinical outcomes. Computational modeling can help optimize FPA repair, but these simulations heavily depend on the choice of constitutive model describing the arterial behavior. In this study finite element model of the FPA in the standing (straight) and gardening (acutely bent) postures was built using computed tomography data, longitudinal pre-stretch and biaxially determined mechanical properties...
November 21, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#4
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
November 17, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27855665/evaluation-of-a-new-imaging-tool-for-use-with-major-trauma-cases-in-the-emergency-department
#5
Moritz Crönlein, Konstantin Holzapfel, Marc Beirer, Lukas Postl, Karl-Georg Kanz, Dominik Pförringer, Stefan Huber-Wagner, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: The aim of this study was to evaluate potential benefits of a new diagnostic software prototype (Trauma Viewer, TV) automatically reformatting computed tomography (CT) data on diagnostic speed and quality, compared to CT-image data evaluation using a conventional CT console. METHODS: Multiple trauma CT data sets were analysed by one expert radiology and one expert traumatology fellow independently twice, once using the TV and once using the secondary conventional CT console placed in the CT control room...
November 17, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27829159/dixdc1-phosphorylation-and-control-of-dendritic-morphology-are-impaired-by-rare-genetic-variants
#6
Vickie Kwan, Durga Praveen Meka, Sean H White, Claudia L Hung, Nicholas T Holzapfel, Susan Walker, Nadeem Murtaza, Brianna K Unda, Birgit Schwanke, Ryan K C Yuen, Kendra Habing, Chloe Milsom, Kristin J Hope, Ray Truant, Stephen W Scherer, Froylan Calderon de Anda, Karun K Singh
The development of neural connectivity is essential for brain function, and disruption of this process is associated with autism spectrum disorders (ASDs). DIX domain containing 1 (DIXDC1) has previously been implicated in neurodevelopmental disorders, but its role in postnatal brain function remains unknown. Using a knockout mouse model, we determined that DIXDC1 is a regulator of excitatory neuron dendrite development and synapse function in the cortex. We discovered that MARK1, previously linked to ASDs, phosphorylates DIXDC1 to regulate dendrite and spine development through modulation of the cytoskeletal network in an isoform-specific manner...
November 8, 2016: Cell Reports
https://www.readbyqxmd.com/read/27821601/photoaging-smartphone-app-promoting-poster-campaign-to-reduce-smoking-prevalence-in-secondary-schools-the-smokerface-randomized-trial-design-and-baseline-characteristics
#7
Titus J Brinker, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Fabian N Fries, Hannah Spielmann, Nancy Rigotti, Werner Seeger, Felix Herth, David A Groneberg, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Anil Batra, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas, Ute Mons, Michael Kreuter
INTRODUCTION: Smoking is the largest cause of preventable death globally. Most smokers smoke their first cigarette in early adolescence. We took advantage of the widespread availability of mobile phones and adolescents' interest in appearance to develop a free photoaging app which is promoted via a poster campaign in secondary schools. This study aims to evaluate its effectiveness regarding smoking prevalence and students' attitudes towards smoking. METHODS AND ANALYSIS: A randomised controlled trial is conducted with 9851 students of both genders with an average age of 12 years in grades 6 and 7 of 126 secondary schools in Germany...
November 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27789080/evaluation-of-hydropeaking-impacts-on-the-food-web-in-alpine-streams-based-on-modelling-of-fish-and-macroinvertebrate-habitats
#8
P Holzapfel, P Leitner, H Habersack, W Graf, C Hauer
Hydropeaking as a result of peak-load electricity production has been identified as one of the most significant pressures in alpine streams. Scouring of macroinvertebrates leads to downstream transport of aquatic organisms (catastrophic drift). Additionally, invertebrates are affected by periodic drying of wetted area during the dewatering of gravel bars and exposed areas along the banks. Even though fish are physiologically better adapted to switch to suitable habitats, artificial flow fluctuations may be followed by lethal stranding and quick alteration in habitat quantity and quality...
October 24, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27782196/intrinsic-and-extrinsic-pinning-in-ndfeas-o-f-vortex-trapping-and-lock-in-by-the-layered-structure
#9
C Tarantini, K Iida, J Hänisch, F Kurth, J Jaroszynski, N Sumiya, M Chihara, T Hatano, H Ikuta, S Schmidt, P Seidel, B Holzapfel, D C Larbalestier
Fe-based superconductors (FBS) present a large variety of compounds whose properties are affected to different extents by their crystal structures. Amongst them, the REFeAs(O,F) (RE1111, RE being a rare-earth element) is the family with the highest critical temperature Tc but also with a large anisotropy and Josephson vortices as demonstrated in the flux-flow regime in Sm1111 (Tc ∼ 55 K). Here we focus on the pinning properties of the lower-Tc Nd1111 in the flux-creep regime. We demonstrate that for H//c critical current density Jc at high temperatures is dominated by point-defect pinning centres, whereas at low temperatures surface pinning by planar defects parallel to the c-axis and vortex shearing prevail...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27755715/spreaders-igniters-and-burning-shrubs-plant-flammability-explains-novel-fire-dynamics-in-grass-invaded-deserts
#10
Andres Fuentes-Ramirez, Joseph W Veldman, Claus Holzapfel, Kirk A Moloney
Novel fire regimes are an important cause and consequence of global environmental change that involve interactions among biotic, climatic, and human components of ecosystems. Plant flammability is key to these interactions, yet few studies directly measure flammability or consider how multiple species with different flammabilities interact to produce novel fire regimes. Deserts of the southwestern United States are an ideal system for exploring how novel fire regimes can emerge when fire-promoting species invade ecosystems comprised of species that did not evolve with fire...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27748959/study-of-ethanol-induced-golgi-disorganization-reveals-the-potential-mechanism-of-alcohol-impaired-n-glycosylation
#11
Carol A Casey, Ganapati Bhat, Melissa S Holzapfel, Armen Petrosyan
BACKGROUND: It is known that ethanol (EtOH) and its metabolites have a negative effect on protein glycosylation. The fragmentation of the Golgi apparatus induced by alteration of the structure of largest Golgi matrix protein, giantin, is the major consequence of damaging effects of EtOH-metabolism on the Golgi; however, the link between this and abnormal glycosylation remains unknown. Because previously we have shown that Golgi morphology dictates glycosylation, we examined the effect EtOH administration has on function of Golgi residential enzymes involved in N-glycosylation...
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27682646/prophylactic-total-gastrectomy-in-the-management-of-hereditary-tumor-syndromes
#12
Dimitrios Pantelis, Robert Hüneburg, Ronja Adam, Stefanie Holzapfel, Heidrun Gevensleben, Jacob Nattermann, Christian P Strassburg, Stefan Aretz, Jörg C Kalff
PURPOSE: Germline mutations in several genes confer a relevant lifetime risk of gastric cancer. In this context, an increasing involvement of a surgeon can be seen, mainly with the question of performing a prophylactic operation. METHODS: Patients with hereditary tumor syndromes predisposing for gastric cancer who received care leading to prophylactic total gastrectomy in our Center for Hereditary Tumor Syndromes were analyzed. For each patient, the multidisciplinary decision-making process, the perioperative course, and the histopathologic findings were assessed...
September 28, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27633101/development-of-putative-probiotics-as-feed-additives-validation-in-a-porcine-specific-gastrointestinal-tract-model
#13
Soyoung Yeo, Suro Lee, Hyunjoon Park, Heuynkil Shin, Wilhelm Holzapfel, Chul Sung Huh
Enforced restrictions on the use of antibiotics as growth promoters (AGPs) in animal production have prompted investigations into alternative feed additives in recent decades. Probiotics are currently the main feed additive used in livestock. However, the selection of probiotic candidates relies on human-based methods and little is known about the verification criteria for host-specific selection. We investigated the probiotic potential of Lactobacillus salivarius strains isolated from fed pig feces for their use as porcine feed additives...
December 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27596018/flowers-regulate-the-growth-and-vascular-development-of-the-inflorescence-rachis-in-vitis-vinifera-l
#14
Aude M Gourieroux, Margaret E McCully, Bruno P Holzapfel, Geoffrey R Scollary, Suzy Y Rogiers
The rachis, the structural framework of the grapevine (Vitis vinifera L.) inflorescence (and subsequent bunch), consists of a main axis and one or more orders of lateral branches with the flower-bearing pedicels at their fine tips. The rachis is crucial both for support, and transport from the shoot. Earlier suggestions that the flowers per se affect normal rachis development are investigated further in this study. Different percentages (0, 25, 50, 75 or 100) of flowers were removed manually one week before anthesis on field-grown vines...
August 28, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27586416/pleiotropic-roles-of-the-matricellular-protein-sparc-in-tendon-maturation-and-ageing
#15
Renate Gehwolf, Andrea Wagner, Christine Lehner, Amy D Bradshaw, Cornelia Scharler, Justyna A Niestrawska, Gerhard A Holzapfel, Hans-Christian Bauer, Herbert Tempfer, Andreas Traweger
Acute and chronic tendinopathies remain clinically challenging and tendons are predisposed to degeneration or injury with age. Despite the high prevalence of tendon disease in the elderly, our current understanding of the mechanisms underlying the age-dependent deterioration of tendon function remains very limited. Here, we show that Secreted protein acidic and rich in cysteine (Sparc) expression significantly decreases in healthy-aged mouse Achilles tendons. Loss of Sparc results in tendon collagen fibrillogenesis defects and Sparc-/- tendons are less able to withstand force in comparison with their respective wild type counterparts...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27566370/tissue-engineering-and-regenerative-medicine-in-musculoskeletal-oncology
#16
Boris Michael Holzapfel, Ferdinand Wagner, Laure Christine Martine, Stephan Reppenhagen, Maximilian Rudert, Michael Schuetz, Jim Denham, Jan-Thorsten Schantz, Dietmar Werner Hutmacher
Currently used surgical techniques to reconstruct tissue defects after resection of musculoskeletal tumours are associated with high complication rates. This drives a strong demand for innovative therapeutic concepts that are able to improve the clinical outcomes of patients suffering from bone and soft tissue tumours. Tissue engineering and regenerative medicine (TE&RM) provides a technology platform based on biochemical, molecular, cellular and biomaterials modules to selectively direct tissue healing processes for improved defect regeneration...
September 2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/27563950/searches-for-sterile-neutrinos-with-the-icecube-detector
#17
M G Aartsen, K Abraham, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, M Archinger, C Argüelles, T C Arlen, J Auffenberg, S Axani, X Bai, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, E Blaufuss, S Blot, D J Boersma, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Braun, L Brayeur, H-P Bretz, A Burgman, J Casey, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, A H Cruz Silva, J Daughhetee, J C Davis, M Day, J P A M de André, C De Clercq, E Del Pino Rosendo, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, S Euler, P A Evenson, S Fahey, A R Fazely, J Feintzeig, J Felde, K Filimonov, C Finley, S Flis, C-C Fösig, T Fuchs, T K Gaisser, R Gaior, J Gallagher, L Gerhardt, K Ghorbani, W Giang, L Gladstone, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, D Góra, D Grant, Z Griffith, A Haj Ismail, A Hallgren, F Halzen, E Hansen, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, K Holzapfel, A Homeier, K Hoshina, F Huang, M Huber, W Huelsnitz, K Hultqvist, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, M Jurkovic, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, A Kheirandish, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, C Krüger, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, M Labare, J L Lanfranchi, M J Larson, D Lennarz, M Lesiak-Bzdak, M Leuermann, L Lu, J Lünemann, J Madsen, G Maggi, K B M Mahn, S Mancina, M Mandelartz, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, A Meli, T Menne, G Merino, T Meures, S Miarecki, E Middell, L Mohrmann, T Montaruli, M Moulai, R Nahnhauer, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A Omairat, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, J A Pepper, C Pérez de Los Heros, C Pfendner, D Pieloth, E Pinat, J Posselt, P B Price, G T Przybylski, M Quinnan, C Raab, M Rameez, K Rawlins, M Relich, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, L Sabbatini, J Salvado, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, K Satalecka, P Schlunder, T Schmidt, S Schöneberg, A Schönwald, D Seckel, S Seunarine, D Soldin, M Song, G M Spiczak, C Spiering, M Stamatikos, T Stanev, A Stasik, A Steuer, T Stezelberger, R G Stokstad, A Stößl, R Ström, N L Strotjohann, G W Sullivan, M Sutherland, H Taavola, I Taboada, J Tatar, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, A Turcati, E Unger, M Usner, S Vallecorsa, J Vandenbroucke, N van Eijndhoven, S Vanheule, M van Rossem, J van Santen, J Veenkamp, M Voge, M Vraeghe, C Walck, A Wallace, N Wandkowsky, Ch Weaver, C Wendt, S Westerhoff, B J Whelan, K Wiebe, L Wille, D R Williams, L Wills, H Wissing, M Wolf, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, M Zoll
The IceCube neutrino telescope at the South Pole has measured the atmospheric muon neutrino spectrum as a function of zenith angle and energy in the approximate 320 GeV to 20 TeV range, to search for the oscillation signatures of light sterile neutrinos. No evidence for anomalous ν_{μ} or ν[over ¯]_{μ} disappearance is observed in either of two independently developed analyses, each using one year of atmospheric neutrino data. New exclusion limits are placed on the parameter space of the 3+1 model, in which muon antineutrinos experience a strong Mikheyev-Smirnov-Wolfenstein-resonant oscillation...
August 12, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27476653/exome-sequencing-identifies-biallelic-msh3-germline-mutations-as-a-recessive-subtype-of-colorectal-adenomatous-polyposis
#18
Ronja Adam, Isabel Spier, Bixiao Zhao, Michael Kloth, Jonathan Marquez, Inga Hinrichsen, Jutta Kirfel, Aylar Tafazzoli, Sukanya Horpaopan, Siegfried Uhlhaas, Dietlinde Stienen, Nicolaus Friedrichs, Janine Altmüller, Andreas Laner, Stefanie Holzapfel, Sophia Peters, Katrin Kayser, Holger Thiele, Elke Holinski-Feder, Giancarlo Marra, Glen Kristiansen, Markus M Nöthen, Reinhard Büttner, Gabriela Möslein, Regina C Betz, Angela Brieger, Richard P Lifton, Stefan Aretz
In ∼30% of families affected by colorectal adenomatous polyposis, no germline mutations have been identified in the previously implicated genes APC, MUTYH, POLE, POLD1, and NTHL1, although a hereditary etiology is likely. To uncover further genes with high-penetrance causative mutations, we performed exome sequencing of leukocyte DNA from 102 unrelated individuals with unexplained adenomatous polyposis. We identified two unrelated individuals with differing compound-heterozygous loss-of-function (LoF) germline mutations in the mismatch-repair gene MSH3...
August 4, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27458430/produce-from-africa-s-gardens-potential-for-leafy-vegetable-and-fruit-fermentations
#19
REVIEW
Folarin A Oguntoyinbo, Vincenzina Fusco, Gyu-Sung Cho, Jan Kabisch, Horst Neve, Wilhelm Bockelmann, Melanie Huch, Lara Frommherz, Bernhard Trierweiler, Biserka Becker, Nabil Benomar, Antonio Gálvez, Hikmate Abriouel, Wilhelm H Holzapfel, Charles M A P Franz
A rich variety of indigenous fruits and vegetables grow in Africa, which contribute to the nutrition and health of Africa's populations. Fruits and vegetables have high moisture and are thus inherently prone to accelerated spoilage. Food fermentation still plays a major role in combating food spoilage and foodborne diseases that are prevalent in many of Africa's resource disadvantaged regions. Lactic acid fermentation is probably the oldest and best-accepted food processing method among the African people, and is largely a home-based process...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27455072/does-anticoagulant-medication-alter-fracture-healing-a-morphological-and-biomechanical-evaluation-of-the-possible-effects-of-rivaroxaban-and-enoxaparin-using-a-rat-closed-fracture-model
#20
Peter Michael Prodinger, Rainer Burgkart, Kilian Kreutzer, Franz Liska, Hakan Pilge, Andreas Schmitt, Martina Knödler, Boris Michael Holzapfel, Alexander Hapfelmeier, Thomas Tischer, Oliver Bissinger
Low molecular weight heparin (LMWH) is routinely used to prevent thromboembolism in orthopaedic surgery, especially in the treatment of fractures or after joint-replacement. Impairment of fracture-healing due to increased bone-desorption, delayed remodelling and lower calcification caused by direct osteoclast stimulation is a well-known side effect of unfractioned heparin. However, the effect of LMWH is unclear and controversial. Recent studies strongly suggest impairment of bone-healing in-vitro and in animal models, characterized by a significant decrease in volume and quality of new-formed callus...
2016: PloS One
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