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https://www.readbyqxmd.com/read/28822475/an-observational-study-on-recurrences-of-low-back-pain-during-the-first-12-months-after-chiropractic-treatment
#1
Christina Knecht, Barry Kim Humphreys, Brigitte Wirth
OBJECTIVES: The purpose of this study was to investigate recurrence rate and prognostic factors in a large population of patients with low back pain (LBP) up to 1 year after chiropractic care using standardized definitions. METHODS: In Switzerland, 722 patients with LBP (375 male; mean age = 44.5 ± 13.8 years) completed the Numeric Rating Scale for pain (NRS) and the Oswestry Disability Index (ODI) before treatment and 1, 3, 6, and 12 months later (ODI up to 3 months)...
July 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28819030/estimates-of-burden-and-consequences-of-infants-born-small-for-gestational-age-in-low-and-middle-income-countries-with-intergrowth-21-st-standard-analysis-of-cherg%C3%A2-datasets
#2
Anne Cc Lee, Naoko Kozuki, Simon Cousens, Gretchen A Stevens, Hannah Blencowe, Mariangela F Silveira, Ayesha Sania, Heather E Rosen, Christentze Schmiegelow, Linda S Adair, Abdullah H Baqui, Fernando C Barros, Zulfiqar A Bhutta, Laura E Caulfield, Parul Christian, Siân E Clarke, Wafaie Fawzi, Rogelio Gonzalez, Jean Humphrey, Lieven Huybregts, Simon Kariuki, Patrick Kolsteren, John Lusingu, Dharma Manandhar, Aroonsri Mongkolchati, Luke C Mullany, Richard Ndyomugyenyi, Jyh Kae Nien, Dominique Roberfroid, Naomi Saville, Dianne J Terlouw, James M Tielsch, Cesar G Victora, Sithembiso C Velaphi, Deborah Watson-Jones, Barbara A Willey, Majid Ezzati, Joy E Lawn, Robert E Black, Joanne Katz
Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21(st) birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestational age, birth weight, and neonatal follow-up. Small for gestational age was defined as infants weighing less than the 10th centile birth weight for gestational age and sex with the multiethnic, INTERGROWTH-21(st) birth weight standard...
August 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28818950/elimination-of-the-male-reproductive-tract-in-the-female-embryo-is-promoted-by-coup-tfii-in-mice
#3
Fei Zhao, Heather L Franco, Karina F Rodriguez, Paula R Brown, Ming-Jer Tsai, Sophia Y Tsai, Humphrey H-C Yao
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action...
August 18, 2017: Science
https://www.readbyqxmd.com/read/28818527/prostate-specific-antigen-testing-after-radical-prostatectomy-can-we-stop-at-20-years
#4
Wesley W Ludwig, Zhaoyong Feng, Bruce J Trock, Elizabeth Humphreys, Patrick C Walsh
PURPOSE: To examine the clinical features and outcomes associated with delayed biochemical recurrence after radical prostatectomy, specifically amongst men with over 20 years of follow-up. MATERIALS AND METHODS: 16,720 men underwent radical prostatectomy and 2,699 experienced biochemical recurrence. We determined predictors of delayed biochemical recurrence as well as metastasis-free survival and cancer specific survival rates for recurrence at various time points after radical prostatectomy...
August 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28815015/exploring-the-definition-of-%C3%A2-acute%C3%A2-neck-pain-a-prospective-cohort-observational-study-comparing-the-outcomes-of-chiropractic-patients-with-0-2%C3%A2-weeks-2-4%C3%A2-weeks-and-4-12%C3%A2-weeks-of-symptoms
#5
Luana Nyirö, Cynthia K Peterson, B Kim Humphreys
BACKGROUND: Neck pain is a common complaint in chiropractic patients. Amongst other baseline variables, numerous studies identify duration of symptoms as a strong predictor of outcome in neck pain patients. The usual time frame used for 'acute' onset of pain is between 0 and 4 weeks. However, the appropriateness of this time frame has been challenged for chiropractic low back pain patients. Therefore, the purpose of this study was to compare outcomes in neck pain patients with 0-2 vs 2-4 and 4-12 weeks of symptoms undergoing chiropractic treatment...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28814511/targeting-phospholipase-d4-attenuates-kidney-fibrosis
#6
Priyanka Trivedi, Ramya K Kumar, Ashwin Iyer, Sarah Boswell, Casimiro Gerarduzzi, Vivekkumar P Dadhania, Zach Herbert, Nikita Joshi, James P Luyendyk, Benjamin D Humphreys, Vishal S Vaidya
Phospholipase D4 (PLD4), a single-pass transmembrane glycoprotein, is among the most highly upregulated genes in murine kidneys subjected to chronic progressive fibrosis, but the function of PLD4 in this process is unknown. Here, we found PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine and human kidneys after fibrosis. Genetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial cells, protected mice from the development of fibrosis. Mechanistically, global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the upregulation of the TGF-β signaling pathway and α1-antitrypsin protein (a serine protease inhibitor) expression and downregulation of neutrophil elastase (NE) expression induced by obstructive injury...
August 16, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28813259/alternatives-for-abandoned-children-insights-from-the-bucharest-early-intervention-project
#7
REVIEW
Charles H Zeanah, Kathryn L Humphreys, Nathan A Fox, Charles A Nelson
The Bucharest Early Intervention Project is the first and only randomized controlled trial of foster care as an alternative to institutional care for orphaned and abandoned children. Across various domains of brain and behavioral development we demonstrated that children in families developed more favorably than children in institutions, that foster care remediates some but not all compromises associated with institutional placement and that earlier placement in foster care leads to more developmental gains in some but not all domains...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28810919/patterns-of-resident-health-workforce-turnover-and-retention-in-remote-communities-of-the-northern-territory-of-australia-2013-2015
#8
Deborah J Russell, Yuejen Zhao, Steven Guthridge, Mark Ramjan, Michael P Jones, John S Humphreys, John Wakerman
BACKGROUND: The geographical maldistribution of the health workforce is a persisting global issue linked to inequitable access to health services and poorer health outcomes for rural and remote populations. In the Northern Territory (NT), anecdotal reports suggest that the primary care workforce in remote Aboriginal communities is characterised by high turnover, low stability and high use of temporary staffing; however, there is a lack of reliable information to guide workforce policy improvements...
August 15, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28807035/artemisinin-combination-therapy-mass-drug-administration-in-a-setting-of-low-malaria-endemicity-programmatic-coverage-and-adherence-during-an-observational-study-in-zanzibar
#9
Abdullah S Ali, Narjis G Thawer, Bakar Khatib, Haji H Amier, Joseph Shija, Mwinyi Msellem, Abdul-Wahid Al-Mafazy, Issa A Garimo, Humphrey Mkali, Mahdi M Ramsan, Jessica M Kafuko, Lynn A Paxton, Richard Reithinger, Jeremiah M Ngondi
BACKGROUND: Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest administration unit) that had been identified as hotspots through Zanzibar's malaria case notification surveillance system. METHODS: Mass drug administration was done in four shehias selected on the basis of: being an established malaria hot spot; having had mass screening and treatment (MSaT) 2-6 weeks previously; and exceeding the epidemic alert threshold of 5 cases within a week even after MSaT...
August 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28806437/association-between-enactment-of-a-stand-your-ground-self-defense-law-and-unlawful-homicides-in-florida
#10
David K Humphreys, Antonio Gasparrini, Douglas J Wiebe
No abstract text is available yet for this article.
August 14, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28800648/fundus-autofluorescence-findings-in-eyes-with-birdshot-chorioretinitis
#11
Christian Böni, Jennifer E Thorne, Richard F Spaide, Trucian A Ostheimer, David Sarraf, Ralph D Levinson, Debra A Goldstein, Lana M Rifkin, Albert T Vitale, Glenn J Jaffe, Gary N Holland
Purpose: The purpose of this study was to describe fundus autofluorescence (FAF) findings in eyes with birdshot chorioretinitis (BSCR) and to compare findings to demographic, medical, and clinical characteristics. Methods: In this multicenter, prospective, cross-sectional study, 172 eyes (86 patients) with BSCR were investigated. Participants underwent a standardized evaluation including collection of demographic data, ophthalmic and treatment history, and ophthalmologic examination...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28797227/changes-in-macular-sensitivity-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#12
Alp Atik, Yijun Hu, Honghua Yu, Chun Yang, Bin Cai, Yijing Tao, Dongli Li, Yan Chen, Li Lu, Guodong Li, Ling Yuan
BACKGROUND: To evaluate the macular sensitivity changes after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). METHODS: Eighteen patients (26 eyes) with chronic CSCR were recruited in the same hospital between April 2011 and December 2012. All patients were treated with one session of half-dose PDT after complete ophthalmic examination. Macular sensitivity examination was performed at baseline and 1, 3 and 6 months post-treatment...
August 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28796875/optical-coherence-tomography-analysis-based-prediction-of-humphrey-24-2-visual-field-thresholds-in-patients-with-glaucoma
#13
Zhihui Guo, Young H Kwon, Kyungmoo Lee, Kai Wang, Andreas Wahle, Wallace L M Alward, John H Fingert, Daniel I Bettis, Chris A Johnson, Mona K Garvin, Milan Sonka, Michael D Abràmoff
Purpose: A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Methods: Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL+IPL) layers were cosegmented and partitioned into 52 sectors matching HVF 24-2 test locations...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28793943/decontamination-of-hospital-surfaces-with-multijet-cold-plasma-a-method-to-enhance-infection-prevention-and-control
#14
Orla J Cahill, Tânia Claro, Attilio A Cafolla, Niall T Stevens, Stephen Daniels, Hilary Humphreys
OBJECTIVE To evaluate the efficacy of a multijet cold-plasma system and its efficacy in decontaminating 2 surfaces commonly found in hospitals DESIGN An in vitro study of common causes of healthcare-acquired infection METHODS Log10 9 cultures of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended spectrum β-lactamase-producing Escherichia coli, and Acinetobacter baumannii were applied to 5-cm2 sections of stainless steel and mattress. Human serum albumin (HSA) was used as a proxy marker for organic material, and atomic force microscopy (AFM) was used to study the impact on bacterial cell structure...
August 10, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28793225/multiscale-and-multiaxial-mechanics-of-vascular-smooth-muscle
#15
Sae-Ii Murtada, Jay D Humphrey, Gerhard A Holzapfel
Mathematical models can facilitate an integrative understanding of the complexity underlying biological structure and function, but they must be informed and validated by empirical data. Uniaxial contraction of an arterial ring is a well-used in vitro approach for studying characteristics of smooth muscle contractility even though this experimental arrangement does not mimic the in vivo vascular geometry or loading. In contrast, biaxial contraction of an inflated and axially extended excised vessel provides broader information, both passive and active, under more realistic conditions...
August 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28792876/nad-deficiency-congenital-malformations-and-niacin-supplementation
#16
Hongjun Shi, Annabelle Enriquez, Melissa Rapadas, Ella M M A Martin, Roni Wang, Julie Moreau, Chai K Lim, Justin O Szot, Eddie Ip, James N Hughes, Kotaro Sugimoto, David T Humphreys, Aideen M McInerney-Leo, Paul J Leo, Ghassan J Maghzal, Jake Halliday, Janine Smith, Alison Colley, Paul R Mark, Felicity Collins, David O Sillence, David S Winlaw, Joshua W K Ho, Gilles J Guillemin, Matthew A Brown, Kazu Kikuchi, Paul Q Thomas, Roland Stocker, Eleni Giannoulatou, Gavin Chapman, Emma L Duncan, Duncan B Sparrow, Sally L Dunwoodie
BACKGROUND: Congenital malformations can be manifested as combinations of phenotypes that co-occur more often than expected by chance. In many such cases, it has proved difficult to identify a genetic cause. We sought the genetic cause of cardiac, vertebral, and renal defects, among others, in unrelated patients. METHODS: We used genomic sequencing to identify potentially pathogenic gene variants in families in which a person had multiple congenital malformations...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28792397/avoiding-globalisation-of-the-prescription-opioid-epidemic
#17
Keith Humphreys
No abstract text is available yet for this article.
July 29, 2017: Lancet
https://www.readbyqxmd.com/read/28783043/nbeal2-is-required-for-neutrophil-and-nk-cell-function-and-pathogen-defense
#18
John M Sowerby, David C Thomas, Simon Clare, Marion Espéli, Jose A Guerrero, Kim Hoenderdos, Katherine Harcourt, Morgan Marsden, Juneid Abdul-Karim, Mathew Clement, Robin Antrobus, Yagnesh Umrania, Philippa R Barton, Shaun M Flint, Jatinder K Juss, Alison M Condliffe, Paul A Lyons, Ian R Humphreys, Edwin R Chilvers, Willem H Ouwehand, Gordon Dougan, Kenneth Gc Smith
Mutations in the human NBEAL2 gene cause gray platelet syndrome (GPS), a bleeding diathesis characterized by a lack of α granules in platelets. The functions of the NBEAL2 protein have not been explored outside platelet biology, but there are reports of increased frequency of infection and abnormal neutrophil morphology in patients with GPS. We therefore investigated the role of NBEAL2 in immunity by analyzing the phenotype of Nbeal2-deficient mice. We found profound abnormalities in the Nbeal2-deficient immune system, particularly in the function of neutrophils and NK cells...
August 7, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28777943/mesenchymal-stem-cells-in-fibrotic-disease
#19
REVIEW
Elie El Agha, Rafael Kramann, Rebekka K Schneider, Xiaokun Li, Werner Seeger, Benjamin D Humphreys, Saverio Bellusci
Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow...
August 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28770841/summer-books
#20
Sharon Weinberger, Louise Humphrey, Anne-Emanuelle Birn, Brad DeLong, Roger D Launius, Michael Mann, Robert P Crease, Marcus Munafò
No abstract text is available yet for this article.
August 2, 2017: Nature
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