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https://www.readbyqxmd.com/read/29240463/assessing-the-validity-of-a-multidisciplinary-mini-clinical-evaluation-exercise
#1
Susan Humphrey-Murto, Mylène Côté, Debra Pugh, Timothy J Wood
Construct: The purpose of this study was to provide validity evidence for the mini-clinical evaluation exercise (mini-CEX) as an assessment tool for clinical skills in the workplace. BACKGROUND: Previous research has demonstrated validity evidence for the mini-CEX, but most studies were carried out in internal medicine or single disciplines, therefore limiting generalizability of the findings. If the mini-CEX is to be used in multidisciplinary contexts, then validity evidence should be gathered in similar settings...
December 14, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29238824/effect-of-perioperative-gabapentin-on-postoperative-pain-resolution-and-opioid-cessation-in-a-mixed-surgical-cohort-a-randomized-clinical-trial
#2
Jennifer Hah, Sean C Mackey, Peter Schmidt, Rebecca McCue, Keith Humphreys, Jodie Trafton, Bradley Efron, Debra Clay, Yasamin Sharifzadeh, Gabriela Ruchelli, Stuart Goodman, James Huddleston, William J Maloney, Frederick M Dirbas, Joseph Shrager, John Costouros, Catherine Curtin, Ian Carroll
Importance: Guidelines recommend using gabapentin to decrease postoperative pain and opioid use, but significant variation exists in clinical practice. Objective: To determine the effect of perioperative gabapentin on remote postoperative time to pain resolution and opioid cessation. Design, Setting, and Participants: A randomized, double-blind, placebo-controlled trial of perioperative gabapentin was conducted at a single-center, tertiary referral teaching hospital...
December 13, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29238759/neuropsychological-evidence-for-the-temporal-dynamics-of-category-specific-naming
#3
Sven Panis, Katrien Torfs, Celine R Gillebert, Johan Wagemans, Glyn W Humphreys
Multiple accounts have been proposed to explain category-specific recognition impairments. Some suggest that category-specific deficits may be caused by a deficit in recurrent processing between the levels of a hierarchically organized visual object recognition system. Here, we tested predictions of interactive processing theories on the emergence of category-selective naming deficits in neurologically intact observers and in patient GA, a single case showing a category-specific impairment for natural objects after a herpes simplex encephalitis infection...
2017: Visual Cognition
https://www.readbyqxmd.com/read/29237512/vancomycin-resistant-enterococci-vre-in-the-intensive-care-unit-in-a-nonoutbreak-setting-identification-of-potential-reservoirs-and-epidemiological-associations-between-patient-and-environmental-vre
#4
Hélène McDermott, Mairead Skally, James O'Rourke, Hilary Humphreys, Deirdre Fitzgerald-Hughes
OBJECTIVE Among nosocomial bloodstream infections caused by enterococcal species, Ireland has the highest proportion caused by vancomycin-resistant enterococci (VRE) in Europe at 45.8%. The contribution of the near-patient environment to VRE transmission outside of outbreaks was investigated. DESIGN A prospective observational study was conducted during 7 sampling periods. METHODS Recovery of VRE isolates by swabbing the near-patient environment and patients in the intensive care unit (ICU) was conducted to identify reservoirs, clinical and molecular epidemiological associations, and the success of active surveillance cultures (ASCs)...
December 14, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29236748/the-diagnostic-use-of-choroidal-thickness-analysis-and-its-correlation-with-visual-field-indices-in-glaucoma-using-spectral-domain-optical-coherence-tomography
#5
Zhongjing Lin, Shouyue Huang, Ping Huang, Lei Guo, Xi Shen, Yisheng Zhong
PURPOSE: To evaluate the quantitative characteristics of choroidal thickness in primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) and in normal eyes using spectral-domain optical coherence tomography (SD-OCT). To evaluate the diagnostic ability of choroidal thickness in glaucoma and to determine the correlation between choroidal thickness and visual field parameters in glaucoma. METHODS: A total of 116 subjects including 40 POAG, 30 NTG and 46 healthy subjects were enrolled in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29232439/body-mass-index-and-breast-cancer-survival-a-mendelian-randomization-analysis
#6
Qi Guo, Stephen Burgess, Constance Turman, Manjeet K Bolla, Qin Wang, Michael Lush, Jean Abraham, Kristiina Aittomäki, Irene L Andrulis, Carmel Apicella, Volker Arndt, Myrto Barrdahl, Javier Benitez, Christine D Berg, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Judith S Brand, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Carlos Caldas, Daniele Campa, Federico Canzian, Jenny Chang-Claude, Stephen J Chanock, Suet-Feung Chin, Fergus J Couch, Angela Cox, Simon S Cross, Cezary Cybulski, Kamila Czene, Hatef Darabi, Peter Devilee, W Ryan Diver, Alison M Dunning, Helena M Earl, Diana M Eccles, Arif B Ekici, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Henrik Flyger, Susan M Gapstur, Mia M Gaudet, Graham G Giles, Gord Glendon, Mervi Grip, Jacek Gronwald, Lothar Haeberle, Christopher A Haiman, Per Hall, Ute Hamann, Susan Hankinson, Jaana M Hartikainen, Alexander Hein, Louise Hiller, Frans B Hogervorst, Bernd Holleczek, Maartje J Hooning, Robert N Hoover, Keith Humphreys, David J Hunter, Anika Hüsing, Anna Jakubowska, Arja Jukkola-Vuorinen, Rudolf Kaaks, Maria Kabisch, Vesa Kataja, Julia A Knight, Linetta B Koppert, Veli-Matti Kosma, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Sara Lindström, Jolanta Lissowska, Jan Lubinski, Mitchell J Machiela, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Federik Marme, John W M Martens, Catriona McLean, Primitiva Menéndez, Roger L Milne, Anna Marie Mulligan, Taru A Muranen, Heli Nevanlinna, Patrick Neven, Sune F Nielsen, Børge G Nordestgaard, Janet E Olson, Jose I A Perez, Paolo Peterlongo, Kelly-Anne Phillips, Christopher J Poole, Katri Pylkäs, Paolo Radice, Nazneen Rahman, Thomas Rüdiger, Anja Rudolph, Elinor J Sawyer, Fredrick Schumacher, Petra Seibold, Caroline Seynaeve, Mitul Shah, Ann Smeets, Melissa C Southey, Rob A E M Tollenaar, Ian Tomlinson, Helen Tsimiklis, Hans-Ulrich Ulmer, Celine Vachon, Ans M W van den Ouweland, Laura J Van't Veer, Hans Wildiers, Walter Willett, Robert Winqvist, M Pilar Zamora, Georgia Chenevix-Trench, Thilo Dörk, Douglas F Easton, Montserrat García-Closas, Peter Kraft, John L Hopper, Wei Zheng, Marjanka K Schmidt, Paul D P Pharoah
Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry...
December 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29230115/interval-colorectal-cancers-at-ochsner-medical-center-where-do-we-stand
#7
Felicia Humphrey, Mariella Gastañaduy, James Smith, Charles B Whitlow
Background: An interval colorectal cancer is a cancer diagnosed prior to the recommended follow-up time from a previously negative colonoscopy. These cancers are thought to arise from a rapidly growing cancer, missed cancer, or incompletely resected adenomas. Our study aimed to identify interval cancers diagnosed during a 4-year period and to identify any potential risk factors associated with these cancers. Secondly, we compared our interval colorectal cancer rate with other published rates...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229983/annotation-free-quantification-of-rna-splicing-using-leafcutter
#8
Yang I Li, David A Knowles, Jack Humphrey, Alvaro N Barbeira, Scott P Dickinson, Hae Kyung Im, Jonathan K Pritchard
The excision of introns from pre-mRNA is an essential step in mRNA processing. We developed LeafCutter to study sample and population variation in intron splicing. LeafCutter identifies variable splicing events from short-read RNA-seq data and finds events of high complexity. Our approach obviates the need for transcript annotations and circumvents the challenges in estimating relative isoform or exon usage in complex splicing events. LeafCutter can be used both to detect differential splicing between sample groups and to map splicing quantitative trait loci (sQTLs)...
December 11, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29226191/time-to-drug-resistant-tuberculosis-treatment-in-a-prospective-south-african-cohort
#9
Brittney J van de Water, Janet Prvu Bettger, Susan Silva, Janice Humphreys, Coleen K Cunningham, Jason E Farley
This study examined time to treatment initiation by age among a prospective cohort with drug-resistant tuberculosis (DR-TB). Participants aged 13 years or older nested within a cluster-randomized trial in 2 South African provinces were evaluated. Outcomes were treatment initiation within 5 days of DR-TB diagnosis (National Tuberculosis Program guidelines) and days from diagnosis to treatment. A total of 521 participants met inclusion criteria. Eighty-two patients (16%) met national guidelines; median time to treatment was 11 days (range = 0-180)...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29219907/the-implementation-of-a-structured-nursing-leadership-development-program-for-succession-planning-in-a-health-system
#10
Priscilla Ramseur, Mary Ann Fuchs, Pamela Edwards, Janice Humphreys
Preparing future nursing leaders to be successful is important because many current leaders will retire in large numbers in the future. A structured nursing leadership development program utilizing the Essentials of Nurse Manager Orientation online program provided future nursing leaders with content aligned with nursing leadership competencies. Paired with assigned mentors and monthly leadership sessions, the participants increased their perception of leadership competence.
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29219618/global-health-watch-5-an-alternative-world-health-report
#11
Humphrey Hodgson
No abstract text is available yet for this article.
December 8, 2017: Medicine, Conflict, and Survival
https://www.readbyqxmd.com/read/29219547/dark-matter-detection-using-helium-evaporation-and-field-ionization
#12
Humphrey J Maris, George M Seidel, Derek Stein
We describe a method for dark matter detection based on the evaporation of helium atoms from a cold surface and their subsequent detection using field ionization. When a dark matter particle scatters off a nucleus of the target material, elementary excitations (phonons or rotons) are produced. Excitations which have an energy greater than the binding energy of helium to the surface can result in the evaporation of helium atoms. We propose to detect these atoms by ionizing them in a strong electric field. Because the binding energy of helium to surfaces can be below 1 meV, this detection scheme opens up new possibilities for the detection of dark matter particles in a mass range down to 1  MeV/c^{2}...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29215806/development-of-an-lcd-based-visual-field-system
#13
Jin Ho Joo, Jihyoung Lee, Heecheon You, Jaheon Kang
BACKGROUND: The present study investigated the diagnostic effectiveness of an LCD-based visual field testing system (LVF) in comparison with the standard automated perimetry Humphrey Field Analyzer II-750i (HFA). METHODS: A randomized controlled crossover study was conducted with 202 normal and 128 glaucomatous eyes using both LVF and HFA. The visual field testing systems were compared in terms of mean deviation (MD), pattern standard deviation (PSD), and area under the receiver operating characteristics curve (AUC) of MD and PSD differentiating the normal and glaucomatous eyes...
January 15, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29214042/maternal-weight-in-the-postpartum-results-from-the-delta-healthy-sprouts-trial
#14
Lisa M Tussing-Humphreys, Jessica L Thomson, Nefertiti OjiNjideka Hemphill, Melissa H Goodman, Alicia S Landry
Background: Excessive postnatal weight retention may pose a threat to a woman's health and future pregnancies. Women in the Lower Mississippi Delta (LMD) region of Mississippi suffer from among the highest rates of obesity in the U.S. and are more likely to gain an excessive amount of weight during pregnancy. The aim of this study was to determine if LMD women who received a lifestyle enhanced maternal, infant, and early childhood home visiting (MIECHV) curriculum had more favorable weight outcomes through 12-months postpartum compared to women who received a standard MIECHV curriculum...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29213127/multivalent-fc%C3%AE-receptor-engagement-by-a-hexameric-fc-fusion-protein-triggers-fc%C3%AE-receptor-internalisation-and-modulation-of-fc%C3%AE-receptor-functions
#15
O S Qureshi, T F Rowley, F Junker, S J Peters, S Crilly, J Compson, A Eddleston, H Björkelund, K Greenslade, M Parkinson, N L Davies, R Griffin, T L Pither, K Cain, L Christodoulou, L Staelens, E Ward, J Tibbitts, A Kiessling, B Smith, F R Brennan, M Malmqvist, F Fallah-Arani, D P Humphreys
Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammatory conditions. We have generated a hexameric-Fc fusion protein (hexameric-Fc) and tested the consequences of multi-valent Fcγ-receptor engagement in in vitro and in vivo systems. In vitro engagement of hexameric-Fc with FcγRs showed complex binding interactions that altered with receptor density and triggered the internalisation and degradation of Fcγ-receptors...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29213066/crispr-cas9-mediated-mutation-of-mouse-il-1%C3%AE-nuclear-localisation-sequence-abolishes-expression
#16
Michael J D Daniels, Antony D Adamson, Neil Humphreys, David Brough
Inflammation is a host defense process against infection. Inflammatory mediators include cytokines of the interleukin-1 family, such as IL-1α and IL-1β. Unlike IL-1β, IL-1α carries an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nucleus. The importance of IL-1α nuclear localisation is poorly understood. Here, we used CRISPR/Cas9 to make inactivating mutations to the NLS on the Il1a gene. A colony of NLS mutant mice was successfully generated with precise knock-in mutations to incapacitate NLS function...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212766/bright-spots-physical-activity-investments-that-work-active-everyday-sheffield-s-physical-activity-service-for-all-people-living-with-and-beyond-cancer
#17
Liam Humphreys, Helen Crank, Gabbi Frith, Helen Speake, Lindsey J Reece
No abstract text is available yet for this article.
December 6, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29210141/extending-addiction-s-conflict-of-interest-policy-to-cover-the-emerging-cannabis-industry
#18
EDITORIAL
Keith Humphreys, Shane Darke, John Marsden, Robert West
No abstract text is available yet for this article.
December 5, 2017: Addiction
https://www.readbyqxmd.com/read/29204845/six-month-emergency-department-use-among-older-adults-following-jail-incarceration
#19
Jessi Humphreys, Cyrus Ahalt, Irena Stijacic-Cenzer, Eric Widera, Brie Williams
Although the number of older adults who are arrested and subject to incarceration in jail is rising dramatically, little is known about their emergency department (ED) use or the factors associated with that use. This lack of knowledge impairs the ability to design evidence-based approaches to care that would meet the needs of this population. This 6-month longitudinal study aimed to determine the frequency of 6-month ED use among 101 adults aged 55 or older enrolled while in jail and to identify factors associated with that use...
December 4, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29197998/multisensory-enhancement-elicited-by-unconscious-visual-stimuli
#20
Ayla Barutchu, Charles Spence, Glyn W Humphreys
The merging of information from different senses (i.e., multisensory integration) can facilitate information processing. Processing enhancements have been observed with signals that are irrelevant to the task at hand, and with cues that are non-predictive. Such findings are consistent with the notion that multiple sensory signals are sometimes integrated automatically. Multisensory enhancement has even been reported with stimuli that have been presented subliminally, though only with meaningful multisensory relations that have already been learned...
December 2, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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