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https://www.readbyqxmd.com/read/28346314/radiographic-review-of-helical-blade-vs-lag-screw-fixation-for-cephalomedullary-nailing-of-low-energy-pertrochanteric-femur-fractures-there-is-a-difference-in-cutout
#1
Lorraine C Stern, John T Gorczyca, Stephen Kates, John Ketz, Gillian Soles, Catherine A Humphrey
OBJECTIVES: To compare the rate of cutout of helical blades and lag screws in low energy peritrochanteric femur fractures treated with a cephalomedullary nail. DESIGN: Retrospective review. SETTING: Academic medical center. PATIENTS: Overall, this study included 362 patients with an average age of 83 years old, a majority of whom were female, and had sustained a low energy peritrochanteric femur fracture treated with a cephalomedullary nail...
March 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28345568/prognosis-of-different-glaucomas-seen-at-a-tertiary-center-a-10-year-overview
#2
Ramanjit Sihota, Neha Midha, Harathy Selvan, Talvir Sidhu, Deepa R Swamy, Ajay Sharma, Amisha Gupta, Viney Gupta, Tanuj Dada, Sunil Chaudhary
AIM: This study aims to determine treatment patterns, long-term intraocular pressure (IOP) and perimetric control in different glaucomas seen at a tertiary eye center. SETTINGS AND DESIGN: Hospital-based, cross-sectional chart review of patients routinely following up at an outpatient glaucoma service. METHODS: Patients with a follow-up of at least 10 years were evaluated. Their mean IOP, visual field (VF) status, and medications/surgery required at final assessment were noted...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28341765/quantifying-the-hepatotoxic-risk-of-alcohol-consumption-in-patients-with-rheumatoid-arthritis-taking-methotrexate
#3
Jenny H Humphreys, Alexander Warner, Ruth Costello, Mark Lunt, Suzanne M M Verstappen, William G Dixon
BACKGROUND: Patients with rheumatoid arthritis (RA) who take methotrexate (MTX) are advised to limit their alcohol intake due to potential combined hepatotoxicity. However, data are limited to support this. The aim of this study was to quantify the risk of developing abnormal liver blood tests at different levels of alcohol consumption, using routinely collected data from primary care. METHODS: Patients with RA in the Clinical Practice Research Datalink starting MTX between 1987 and 2016 were included...
March 23, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28339543/climatic-factors-and-prevalence-of-campylobacter-in-commercial-broiler-flocks-in-thailand
#4
S Prachantasena, P Charununtakorn, S Muangnoicharoen, L Hankla, N Techawal, P Chaveerach, P Tuitemwong, N Chokesajjawatee, N Williams, T Humphrey, T Luangtongkum
Campylobacter are bacteria associated with human foodborne disease worldwide. Poultry and poultry products are generally considered as a main source of these organisms. Compared to temperate zones, baseline information on Campylobacter in tropical regions is limited. Thus, the objectives of the present study were 1) to determine the prevalence of Campylobacter in Thai broiler flocks and 2) to investigate the association between climatic factors (i.e., rainfall, ambient temperature, and relative humidity) and Campylobacter colonization status of broiler flocks in Thailand...
October 6, 2016: Poultry Science
https://www.readbyqxmd.com/read/28333894/m-s-smart-system-contrast-sensitivity-measurements-compared-with-standard-visual-function-measurements-in-primary-open-angle-glaucoma-patients
#5
Jessica L Liu, J Jason McAnany, Jacob T Wilensky, Ahmad A Aref, Thasarat S Vajaranant
PURPOSE: To evaluate the nature and extent of letter contrast sensitivity (CS) deficits in glaucoma patients using a commercially available computer-based system (M&S Smart System II) and to compare the letter CS measurements to standard clinical measures of visual function. METHODS: Ninety-four subjects with primary open-angle glaucoma participated. Each subject underwent visual acuity, letter CS, and standard automated perimetry testing (Humphrey SITA 24-2). All subjects had a best-corrected visual acuity (BCVA) of 0...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28332677/tuneable-reversible-redox-of-cobalt-iii-carbazole-complexes
#6
Michael S Bennington, Humphrey L C Feltham, Zoë J Buxton, Nicholas G White, Sally Brooker
Four tridentate carbazole-based ligands, HL((t)Bu/H) {3,6-di(tert-butyl)-1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole}, HL((t)Bu/(t)Bu) {3,6-di(tert-butyl)-1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, HL(H/H) {1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole} and HL(H/(t)Bu) {1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, were prepared and complexed with cobalt(ii) tetrafluoroborate. In situ air oxidation resulted in cobalt(iii) complexes 1-4 with the general formula [Co(III)(L)2]BF4·xH2O (1: L = L((t)Bu/H), x = 2; 2: L = L((t)Bu/(t)Bu), x = 1; 3: L = L(H/H), x = 0...
March 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28332622/b-lymphocytes-play-a-limited-role-in-clearance-of-campylobacter-jejuni-from-the-chicken-intestinal-tract
#7
Lizeth Lacharme-Lora, Gemma Chaloner, Rachel Gilroy, Suzanne Humphrey, Kirsty Gibbs, Sue Jopson, Elli Wright, William Reid, Julian Ketley, Tom Humphrey, Nicola Williams, Steven Rushton, Paul Wigley
Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis with contaminated poultry meat its main source. Control of C. jejuni is a priority for the poultry industry but no vaccines are available and their development hampered by poor understanding of the immunobiology of C. jejuni infection. Here we show the functional role of B lymphocytes in response to C. jejuni in the chicken through depletion of the B lymphocyte population (bursectomy) followed by challenge. B lymphocyte depletion has little effect on bacterial numbers in the ceca, the main site of colonisation, where C...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332080/erratum-to-impaired-social-decision-making-mediates-the-association-between-adhd-and-social-problems
#8
Kathryn L Humphreys, Chardeé A Galán, Nim Tottenham, Steve S Lee
No abstract text is available yet for this article.
March 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28329805/cognitive-function-in-low-income-and-low-literacy-settings-validation-of-the-tablet-based-oxford-cognitive-screen-in-the-health-and-aging-in-africa-a-longitudinal-study-of-an-indepth-community-in-south-africa-haalsi
#9
Glyn W Humphreys, Mihaela D Duta, Livia Montana, Nele Demeyere, Cathal McCrory, Julia Rohr, Kathleen Kahn, Stephen Tollman, Lisa Berkman
Objectives: 1. Assess validity of the Oxford Cognitive Screen (OCS-Plus), a domain-specific cognitive assessment designed for low-literacy settings, especially in low- and middle-income countries (LMIC); 2. Advance theoretical contributions in cognitive neuroscience in domain-specific cognitive function and cognitive reserve, especially related to dementia. Method: In a cross-sectional study of a sample of 1,402 men and women aged 40-79 in the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI), we administered OCS-Plus along with health and sociodemographic assessments...
October 21, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28327271/novel-anti-staphylococcal-and-anti-biofilm-properties-of-two-anti-malarial-compounds-mmv665953-1-3-chloro-4-fluorophenyl-3-3-4-dichlorophenyl-urea-and-mmv665807-5-chloro-2-hydroxy-n-3-trifluoromethyl-phenyl-benzamide
#10
Marta Zapotoczna, Nabila Boksmati, Sinead Donohue, Baizurina Bahtiar, Ahmad Boland, Hamzah Al Somali, Alysia Cox, Hilary Humphreys, James P O'Gara, Marian Brennan, Eoghan O'Neill
PURPOSE: The treatment of device-related infections is challenging and current anti-microbial compounds have poor anti-biofilm activity. We aimed to identify and characterize novel compounds effective in the eradication of Staphylococcus aureus biofilms. METHODOLOGY: Two novel compounds, MMV665953 {1-(3-chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea} and MMV665807{5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide}, effective in killing S. aureus biofilms, were identified by screening of the open access 'malaria box' chemical library...
March 23, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28326356/effect-of-four-monthly-doses-of-a-human-monoclonal-anti-fgf23-antibody-krn23-on-quality-of-life-in-x-linked-hypophosphatemia
#11
Mary D Ruppe, Xiaoping Zhang, Erik A Imel, Thomas J Weber, Mark A Klausner, Takahiro Ito, Maria Vergeire, Jeffrey S Humphrey, Francis H Glorieux, Anthony A Portale, Karl Insogna, Munro Peacock, Thomas O Carpenter
X-linked hypophosphatemia (XLH) is characterized by lower extremity deformities that lead to bone and/or joint pain that result from decreased renal tubular reabsorption leading to hypophosphatemia caused by elevated levels of fibroblast growth factor 23 (FGF23). OBJECTIVE: Validate the use of SF-36v2 Health Survey (SF-36v2) and the Western Ontario and McMaster Osteoarthritis Index (WOMAC) to measure previously unstudied health-related quality of life (HRQoL) in XLH patients and determine the change in HRQoL before and after treatment with KRN23, a human monoclonal anti-FGF23 antibody...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28325865/venetoclax-and-obinutuzumab-in-chronic-lymphocytic-leukemia
#12
Kirsten Fischer, Othman Al-Sawaf, Anna-Maria Fink, Mark Dixon, Jasmin Bahlo, Simon Warburton, Thomas J Kipps, Robert Weinkove, Sue Robinson, Till Seiler, Stephen Opat, Carolyn Owen, Javier López, Kathryn Humphrey, Rod Humerickhouse, Eugen Tausch, Lukas Frenzel, Barbara Eichhorst, Clemens-M Wendtner, Stephan Stilgenbauer, Anton W Langerak, Jacque J M van Dongen, Sebastian Boettcher, Matthias Ritgen, Valentin Goede, Mehrdad Mobasher, Michael Hallek
No abstract text is available yet for this article.
March 21, 2017: Blood
https://www.readbyqxmd.com/read/28325389/the-role-of-imaging-in-the-management-of-patients-with-nonmelanoma-skin-cancer-when-is-imaging-necessary
#13
REVIEW
Tatyana R Humphreys, Komal Shah, Ashley Wysong, Frank Lexa, Deborah MacFarlane
When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available.
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28325388/the-role-of-imaging-in-the-management-of-patients-with-nonmelanoma-skin-cancer-diagnostic-modalities-and-applications
#14
REVIEW
Deborah MacFarlane, Komal Shah, Ashley Wysong, Ximena Wortsman, Tatyana R Humphreys
While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer.
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28325105/geomapping-of-traumatic-spinal-cord-injury-in-canada-and-factors-related-to-triage-pattern
#15
Christiana L Cheng, Vanessa K Noonan, Jayson Shurgold, Jason Chen, Carly S Rivers, Hamid Khaleghi Hamedani, Suzanne Humphreys, Christopher Bailey, Najmedden Attabib, Jean-Marc Mac-Thiong, Michael Goytan, Jérôme Paquet, Richard Fox, Henry Ahn, Brian K Kwon, Daryl R Fourney
Current research indicates that more than half of patients with traumatic spinal cord injury (tSCI) experience delays in transfer and receive surgery more than 24 hours post-injury. The objectives of this study were to determine the geographic distribution of tSCI in Canada relative to specialized treatment facilities, to assess clinical and logistical factors at play for indirect admissions to those facilities, and to explore differences in current time to admission and simulated scenarios in an attempt to assess the potential impact of changes to triage protocols...
March 22, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28324791/spatio-temporal-neighborhood-impacts-on-internalizing-and-externalizing-behaviors-in-u-s-elementary-school-children-effect-modification-by-child-and-family-socio-demographics
#16
Jamie L Humphrey, Elisabeth D Root
Increasing evidence from experimental and non-experimental research has shown that children residing in disadvantaged neighborhoods exhibit greater levels of internalizing and externalizing behaviors, above and beyond individual characteristics, and family or school contexts. Using the ECLS-K, a nationally representative, longitudinal survey of U.S. school children, this study examined direct neighborhood effects on internalizing (N = 14,870; N = 10,610) and externalizing (N = 14,960; N = 10,730) behaviors at the beginning and end of elementary school...
March 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28322902/negative-multi-parametric-mri-of-the-prostate-predicts-absence-of-clinically-significant-prostate-cancer-on-12-core-template-prostate-biopsy
#17
Amanda J Lu, Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, James Rosoff, Michael Spektor, Angelique Levi, Peter A Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
OBJECTIVE: To determine the negative predictive value of multiparametric-MRI (mpMRI), we evaluated the frequency of prostate cancer detection by 12-core template mapping biopsy in men whose mpMRI showed no suspicious regions. METHODS: 670 patients underwent mpMRI followed by transrectal ultrasound-(TRUS) guided systematic prostate biopsy from December 2012 to June 2016. Of this cohort, 100 patients had a negative mpMRI. mpMRI imaging sequences included T2-weighted, diffusion-weighted imaging, and dynamic contrast enhancement sequences...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28321797/self-relevance-effects-and-label-choice-strong-variations-in-label-matching-performance-due-to-non-self-relevant-factors
#18
Gregory L Wade, Timothy J Vickery
Merely associating one's self with a stimulus may be enough to enhance performance in a label-matching paradigm (Sui, He, & Humphreys, 2012), implying prioritized processing of self-relevant stimuli. For instance, labeling a square as SELF and a circle as OTHER yields speeded performance when verifying square-SELF compared with circle-OTHER label matches. The precise causes of such effects are unclear. We propose that prioritized processing of label-matches can occur for reasons other than self-relevance. Here, we employ the label-matching paradigm to show similar benefits for non-self-relevant labels (SNAKE, FROG, and GREG) over a frequently employed, non-self-relevant control label (OTHER)...
March 20, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28321277/clinical-outcomes-among-febrile-children-aged-2-to-59-months-with-negative-malaria-rapid-diagnostic-test-results-in-mchinji-district-malawi
#19
Dyson Mwandama, Chawanangwa Mwale, Andrew Bauleni, Themba Phiri, Joseph Chisaka, Humphreys Nsona, Don P Mathanga
BACKGROUND: Malawi malaria treatment guidelines recommend a definitive diagnosis, using a malaria rapid diagnostic test (mRDT), for all patients with fever or history of fever. Improving the management and outcomes of febrile children with negative mRDT results should be a priority. METHODS: Through a prospective cohort study designed to investigate clinical outcomes of children treated at the community level, we followed, for 7 days, children aged 2 to 59 months, who had negative mRDT results and were treated with antipyretic medication...
December 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28321251/analgesic-effects-of-preincision-ketamine-on-postspinal-caesarean-delivery-in-uganda-s-tertiary-hospital-a-randomized-clinical-trial
#20
Richard Mwase, Tonny Stone Luggya, John Mark Kasumba, Humphrey Wanzira, Andrew Kintu, Joesph V B Tindimwebwa, Daniel Obua
Background. Good postoperative analgesic management improves maternal satisfaction and care of the neonate. Postoperative pain management is a challenge in Mulago Hospital, yet ketamine is accessible and has proven benefit. We determined ketamine's postoperative analgesic effects. Materials and Methods. We did an RCT among consenting parturients that were randomized to receive either intravenous ketamine (0.25 mg/kg) or placebo after spinal anesthetic. Pain was assessed every 30 mins up to 24 hours postoperatively using the numerical rating scale...
2017: Anesthesiology Research and Practice
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