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https://www.readbyqxmd.com/read/28723747/injury-of-optic-radiation-and-visual-field-defect-in-a-patient-with-aneurysmal-subarachnoid-hemorrhage-a-case-report
#1
Sung Ho Jang, Jeong Pyo Seo
RATIONALE: Little is known about optic radiation (OR) injury following aneurysmal subarachnoid hemorrhage (SAH). In the current study, we report on a patient who showed a visual field defect and injury of the OR following aneurysmal SAH, using diffusion tensor tractography (DTT). PATIENT CONCERNS: At 4 weeks from onset, when a 62-year old female started rehabilitation, she complained of a visual field defect. Peripheral field defects were detected on both eyes using the Humphrey visual field test...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720171/pacbio-assembly-of-a-plasmodium-knowlesi-genome-sequence-with-hi-c-correction-and-manual-annotation-of-the-sicavar-gene-family
#2
S A Lapp, J A Geraldo, J-T Chien, F Ay, S B Pakala, G Batugedara, J Humphrey, J D DeBARRY, K G Le Roch, M R Galinski, J C Kissinger
Plasmodium knowlesi has risen in importance as a zoonotic parasite that has been causing regular episodes of malaria throughout South East Asia. The P. knowlesi genome sequence generated in 2008 highlighted and confirmed many similarities and differences in Plasmodium species, including a global view of several multigene families, such as the large SICAvar multigene family encoding the variant antigens known as the schizont-infected cell agglutination proteins. However, repetitive DNA sequences are the bane of any genome project, and this and other Plasmodium genome projects have not been immune to the gaps, rearrangements and other pitfalls created by these genomic features...
July 19, 2017: Parasitology
https://www.readbyqxmd.com/read/28719685/screening-pelvic-examinations
#3
Amir Qaseem, Linda Humphrey, Mary Ann Forciea
No abstract text is available yet for this article.
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28718060/innate-immune-responses-and-osteoarthritis
#4
REVIEW
Evangelia Kalaitzoglou, Timothy M Griffin, Mary Beth Humphrey
PURPOSE OF THE REVIEW: Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory responses that contribute to OA progression and are the focus of this review. RECENT FINDINGS: Recent studies have identified risk factors for OA progression including increased innate immune responses secondary to aging-associated myeloid skewing, obesity-related myeloid activation, and synovial tissue hyperplasia with activated macrophage infiltration...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28716315/understanding-the-economic-impact-of-neurogenic-lower-urinary-tract-dysfunction
#5
REVIEW
Isaac D Palma-Zamora, Humphrey O Atiemo
Neurogenic bladder is a chronic and disabling condition associated with multiple comorbidities and a widespread economic impact. Literature on cost of care and resource utilization is sparse and heterogeneous. Nonstandardized approaches, impact perspectives, and types of costs are used to describe the economic implications of neurogenic bladder. The financial toll is difficult to ascertain due to indirect and intangible costs exacerbated by the underlying disability. Health resource utilization based on clinical manifestations of neurogenic bladder may serve as an alternative measure...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28716057/the-peripheral-and-central-humphrey-visual-field-morphological-changes-during-aging
#6
Paul Rutkowski, Christian Albrecht May
BACKGROUND: To define age-related changes in the visual field by comparing 'standard' central and unique peripheral visual field measurements in healthy volunteers. METHODS: In a single center, retrospective, Cross-sectional, observational study, 20 volunteers with no retinal diseases or risk factors, ranging in age between 30 and 94 years (four age groups: 30's, 50's, 70's, 90's) were measured in one eye (preferentially the right one) using a Humphrey visual field 24-2 and 60-4...
July 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28712384/the-epidemiology-of-invasive-pneumococcal-disease-in-older-adults-in-the-post-pcv-era-has-there-been-a-herd-effect
#7
M Corcoran, I Vickers, J Mereckiene, S Murchan, S Cotter, M Fitzgerald, M McElligott, M Cafferkey, D O'Flanagan, R Cunney, H Humphreys
The 7 and 13-valent pneumococcal conjugate vaccines (PCVs) have reduced the incidence of invasive pneumococcal disease (IPD) in children in many countries. The objective of this work was to assess the impact of PCVs and potential herd-protection in older adults in Ireland. IPD notification and typing data from adults ⩾65 years of age from July 2007 to June 2016 was assessed using national surveillance data. There was a 94% reduction in PCV7 serotypes from 2007-2008 to 2015-2016, incidence rate ratio (IRR 0·05, P < 0·0001)...
August 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28712379/mental-health-difficulties-and-academic-attainment-evidence-for-gender-specific-developmental-cascades-in-middle-childhood
#8
Margarita Panayiotou, Neil Humphrey
We present a developmental cascade model of the longitudinal relationships between internalizing symptoms, externalizing problems, and academic performance in middle childhood, utilizing a large sample (N = 1,771) from the United Kingdom in a 3-year, cross-lag design. Three hypotheses were tested: adjustment erosion, academic incompetence, and (cumulative) shared risk. In addition, we sought to examine whether developmental cascade pathways varied across gender, while also statistically exploring indirect, mediation pathways...
July 17, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28712026/posterior-cruciate-ligament-is-twisted-and-flat-structure-new-prospective-on-anatomical-morphology
#9
Tomohiro Kato, Robert Śmigielski, Yunshen Ge, Urszula Zdanowicz, Bogdan Ciszek, Mitsuo Ochi
PURPOSE: This cadaveric study aimed to elucidate PCL morphology by observing the anatomical relationship with other structures and the fibre layers of the PCL in cross section for remnant preserving PCL reconstruction. METHODS: Seventeen fresh-frozen cadaveric knees were studied, using the clock-face method to analyse the anatomical relationship between the PCL and Humphrey's ligament. The width and thickness of the PCL, Humphrey's and Wrisberg's ligaments were measured...
July 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28707893/dislocations-in-algan-core-structure-atom-segregation-and-optical-properties
#10
Fabien C-P Massabuau, Sneha L Rhode, Matthew K Horton, Thomas J O'Hanlon, Andras Kovacs, Marcin S Zielinski, Menno J Kappers, Rafal E Dunin-Borkowski, Colin J Humphreys, Rachel A Oliver
We conducted a comprehensive investigation of dislocations in Al0.46Ga0.54N. Using aberration-corrected scanning transmission electron microscopy and energy dispersive X-ray spectroscopy, the atomic structure and atom distribution at the dislocation core have been examined. We report that the core configuration of dislocations in AlGaN is consistent with that of other materials in the III-Nitride system. However we observed that the dissociation of mixed-type dislocations is impeded by alloying GaN with AlN, which is confirmed by our experimental observation of Ga and Al atom segregation in the tensile and compressive parts of the dislocations, respectively...
July 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28697611/comparison-of-cow-side-diagnostic-tests-for-subclinical-mastitis-of-dairy-cows-in-musanze-district-rwanda
#11
Blaise Iraguha, Humphrey Hamudikuwanda, Borden Mushonga, Erick Kandiwa, Jean P Mpatswenumugabo
Four subclinical mastitis diagnostic tests (the UdderCheck® test [a lactate dehydrogenasebased test], the California Mastitis Test [CMT], the Draminski® test [a conductivity-based test] and the PortaSCC® test [a portable somatic cell count-based test]) were compared in a study comprising crossbreed dairy cows (n = 30) during September and October 2015. Sensitivity and specificity of the CMT, Draminski® and UdderCheck® tests were compared with the PortaSCC® as reference. The CMT, Draminski® and UdderCheck® test results were compared with the results of the PortaSCC® test using kappa statistics...
June 21, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28697496/spatially-resolved-spectral-sensitivities-as-a-potential-read-out-parameter-in-clinical-gene-therapeutic-trials
#12
Birgit Lorenz, Erika Wegscheider, Christian Hamel, Markus N Preising, Knut Stieger
PURPOSE: Spatially resolved functional assessment of rods and cones under photopic and scotopic conditions is desirable to evaluate the treatment outcome of gene therapeutic applications in inherited retinal disorders, such as early- onset severe retinal dystrophy (EOSRD) or achromatopsia. METHODS: A sample of 3 healthy subjects, 6 patients with RPE65 deficiency (aged 11-45 years), and 3 patients with cone dysfunction disorders underwent spectral sensitivity testing (SST) under conditions of dark and light adaptation using a Humphrey Field Analyzer modified perimeter...
July 12, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28692760/current-trends-in-admissions-and-outcomes-of-cardiac-diseases-in-ghana
#13
Lambert T Appiah, Fred S Sarfo, Charles Agyemang, Humphrey O Tweneboah, Nana Akua B A Appiah, George Bedu-Addo, Ohene Opare-Sem
Cardiovascular diseases (CVDs) pose a major burden in Africa, but data on temporal trends in disease burden are lacking. We assessed trends in CVD admissions and outcomes in central Ghana using a retrospective analysis of data from January 2004 to December 2015 among patients admitted to the medical wards of a tertiary medical center in Kumasi, Ghana. Rates of admissions and mortality were expressed as CVD admissions and deaths divided by the total number of medical admissions and deaths, respectively. Case fatality rates per specific cardiac disease diagnosis were also computed...
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28689167/the-interpretation-of-results-of-10-2-visual-fields-should-consider-individual-variability-in-the-position-of-the-optic-disc-and-temporal-raphe
#14
Fumi Tanabe, Chota Matsumoto, Allison M McKendrick, Sachiko Okuyama, Shigeki Hashimoto, Yoshikazu Shimomura
AIMS: To clarify the anatomical relation between the optic disc and temporal raphe and to examine how these are related to test points in the 10-2 visual field test pattern. SUBJECTS AND METHODS: For 22 eyes of volunteers with normal vision (+0.75 D spherical equivalent 7.88 D), a volume scan was used to obtain en-face images from a plane fitted to the inner limiting membrane using optical coherence tomography (OCT). The clearest en-face retinal nerve fibre (RNF) image was chosen for each subject and superimposed on fundus photographs using blood vessels for alignment...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689044/voyaging-into-the-third-dimension-a-perspective-on-virtual-methods-and-their-application-to-studies-of-juvenile-sex-estimation-and-the-ontogeny-of-sexual-dimorphism
#15
REVIEW
L A B Wilson, L T Humphrey
In contrast to the well-established and highly accurate morphological methods available for sexing adult skeletons, juvenile sex estimation is widely recognised as a difficult task that faces a series of challenges. The acquisition of 3D data, and construction of 3D models from volume or surface scans, has become increasingly common in forensic sciences, and these data offer considerable opportunity for the development and refinement of methods in sex estimation. The suitability and potential of virtual methods for juvenile sex estimation are evaluated with the aims of identifying (1) the benefits and challenges associated with virtual data and quantitative analysis of 3D models, and (2) pathways that may lead to practical improvements for sexing juveniles...
June 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28684101/acquired-unilateral-scotoma
#16
Amir H Marvasti, Kevin C Chen, Henry A Ferreyra, Julie Falardeau
A 54-year-old white man presented with a "blind spot" temporally in his left eye. Best-corrected visual acuity in the affected eye was 20/20 and Humphrey visual field revealed an enlarged blind spot. Funduscopic examination revealed subtle peripapillary pigmentary changes corresponding to a well-demarcated peripapillary region of hyper- and hypoautofluorescence on fundus autofluorescence (FAF). Outer retinal degenerative changes were detected on spectral domain optical coherence tomography (SD-OCT). A diagnosis of Acute zonal occult outer retinopathy (AZOOR) was made based on clinical history and imaging studies...
July 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28681433/prevalence-of-positive-direct-antiglobulin-test-and-clinical-outcomes-in-surinamese-newborns-from-d-negative-women
#17
Rens Zonneveld, Margriet Lamers, Henk Schonewille, Anneke Brand, Humphrey H H Kanhai, Wilco C W R Zijlmans
BACKGROUND: In low-resource countries, screening for D antibodies to detect pregnancies at risk for hemolytic disease of the newborn is not routine practice. Retrospective data showed that 5.5% of Surinamese newborns of D-negative women had a positive direct antiglobulin test (DAT), indicating the presence of maternal antibodies against fetal antigens. Here, the frequency and clinical relevance of DAT positivity is evaluated. STUDY DESIGN AND METHODS: Between April 2015 and June 2016, an observational, multicenter cohort study was undertaken among Surinamese newborns born to D-negative women...
July 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28678098/the-use-of-the-delphi-and-other-consensus-group-methods-in-medical-education-research-a-review
#18
Susan Humphrey-Murto, Lara Varpio, Timothy J Wood, Carol Gonsalves, Lee-Anne Ufholz, Kelly Mascioli, Carol Wang, Thomas Foth
PURPOSE: Consensus group methods, such as the Delphi method and nominal group technique (NGT), are used to synthesize expert opinions when evidence is lacking. Despite their extensive use, these methods are inconsistently applied. Their use in medical education research has not been well studied. The authors set out to describe the use of consensus methods in medical education research and to assess the reporting quality of these methods and results. METHOD: Using scoping review methods, the authors searched the Medline, Embase, PsycInfo, PubMed, Scopus, and ERIC databases for 2009-2016...
July 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28676164/defect-of-the-eyelids
#19
REVIEW
Guanning Nina Lu, Ron W Pelton, Clinton D Humphrey, John David Kriet
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects.
August 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28676160/flap-basics-ii-advancement-flaps
#20
REVIEW
Matthew Shew, John David Kriet, Clinton D Humphrey
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries...
August 2017: Facial Plastic Surgery Clinics of North America
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