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https://www.readbyqxmd.com/read/28089128/management-of-paget-s-disease-of-the-calcaneum
#1
Joel Humphrey, Anum Pervez, Roland Walker, Ali Abbasian, Sam Singh
The calcaneum is not the most common site for Paget's disease of bone, with only a few reports of monostotic involvement. We present 2 cases of Paget's disease of bone affecting the calcaneus, present an overview of the published data, and describe our management of these interesting cases.
January 6, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28087527/floc-formation-reduces-the-ph-stress-experienced-by-microorganisms-living-in-alkaline-environments
#2
C J Charles, S P Rout, K A Patel, S Akbar, A P Laws, B R Jackson, S A Boxall, P N Humphreys
: The survival of microorganisms within a cementitious geological disposal facility for radioactive wastes is heavily dependent on their ability to survive the calcium dominated, hyper-alkaline conditions resulting from the dissolution of the cementitious materials. The present study shows that the formation of flocs, composed of a complex mixture of extracellular polymeric substances (EPS), provides protection against alkaline pH values up to pH 13.0. The flocs were dominated by Alishewanella and Dietzia sp, producing a mannose rich carbohydrate fraction incorporating extracellular DNA, resulting in Ca(2+) sequestration...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28086864/direct-detection-of-falciparum-and-non-falciparum-malaria-dna-from-a-drop-of-blood-with-high-sensitivity-by-the-dried-lamp-system
#3
Kyoko Hayashida, Kiichi Kajino, Humphrey Simukoko, Martin Simuunza, Joseph Ndebe, Amos Chota, Boniface Namangala, Chihiro Sugimoto
BACKGROUND: Because of the low sensitivity of conventional rapid diagnostic tests (RDTs) for malaria infections, the actual prevalence of the diseases, especially those caused by non-Plasmodium falciparum (non-Pf) species, in asymptomatic populations remain less defined in countries lacking in well-equipped facilities for accurate diagnoses. Our direct blood dry LAMP system (CZC-LAMP) was applied to the diagnosis of malaria as simple, rapid and highly sensitive method as an alternative for conventional RDTs in malaria endemic areas where laboratory resources are limited...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28086822/assessment-of-quality-of-care-among-in-patients-with-postpartum-haemorrhage-and-severe-pre-eclampsia-at-st-francis-hospital-nsambya-a-criteria-based-audit
#4
Alfred Lumala, Peter Sekweyama, Andrew Abaasa, Humphrey Lwanga, Romano Byaruhanga
BACKGROUND: The maternal mortality ratio of Uganda is still high and the leading causes of maternal mortality are postpartum haemorrhage (PPH), severe pre-eclampsia and eclampsia. Criteria-based audit (CBA) is a way of improving quality of care that has not been commonly used in low income countries. This study aimed at finding out the quality of care provided to patients with these conditions and to find out if the implementation of recommendations from the audit cycle resulted in improvement in quality of care...
January 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28079654/retinal-oximetry-in-subjects-with-glaucomatous-hemifield-asymmetry
#5
Zhu Li Yap, Charles Ong, Yi Fang Lee, Andrew Tsai, Clarissa Cheng, Monisha E Nongpiur, Shamira A Perera
PURPOSE: Although some studies suggest a strong link between retinal vessel oxygenation and damage to the retinal nerve fiber layer (RNFL) seen in glaucoma, it has yet to be conclusively proven. This study compares intraocular retinal oximetry in glaucomatous eyes displaying asymmetrically affected hemifields across different subgroups of glaucoma, namely primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG). METHODS: In this prospective cross-sectional study, 99 patients (PACG, n=28; POAG, n=37; NTG, n=34) underwent retinal oxygenation and vessel caliber measurements using the Oxymap T1 Retinal Oximeter, Cirrus optical coherence tomography, and Humphrey visual field testing...
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28078698/addiction-debates-challenging-ideas-challenging-ourselves
#6
EDITORIAL
Joanne Neale, Keith Humphreys
No abstract text is available yet for this article.
February 2017: Addiction
https://www.readbyqxmd.com/read/28075567/facile-syntheses-of-ba2-b4o7-oh-2-and-na-b5o7-oh-2-h2o-borate-salts-exhibiting-nonlinear-optical-activity-in-the-ultraviolet
#7
Chao Wu, Longhua Li, Junling Song, Gang Yang, Mark G Humphrey, Chi Zhang
Two novel noncentrosymmetric metal borates, Ba2[B4O7(OH)2] (1) and Na[B5O7(OH)2](H2O) (2), have been obtained by hydrothermal and surfactant-thermal means. Compound 1 consists of novel one-dimensional borate chains formed by B3O9 and B3O8 rings, assembled into a three-dimensional (3D) framework by Ba(2+) cations. The structure of 2 exhibits double-helical chains constructed from B5O10 primary building units, which are interconnected via Na(+) cations and H-bonding interactions to generate a 3D framework. Second-harmonic-generation (SHG) measurements show that 1 shows a phase-matching powder SHG response of ∼2...
January 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28073365/neurophthalmological-conditions-mimicking-glaucomatous-optic-neuropathy-analysis-of-the-most-common-causes-of-misdiagnosis
#8
Diego Torres Dias, Michele Ushida, Roberto Battistella, Syril Dorairaj, Tiago Santos Prata
BACKGROUND: To analyze the most common neurophthalmological conditions that may mimic glaucomatous optic neuropathy and to determine which most often lead to misdiagnosis when evaluated by a glaucoma specialist. METHODS: We reviewed the charts of consecutive patients with optic neuropathies caused by neurophthalmological conditions screened in a single Eye Clinic within a period of 24 months. Within these enrolled patients, we selected the eyes whose fundoscopic appearance could resemble glaucoma based in pre-defined criteria (vertical cup-to-disc ratio ≥0...
January 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28073167/large-extents-of-intensive-land-use-limit-community-reorganization-during-climate-warming
#9
Tom H Oliver, Simon Gillings, James W Pearce-Higgins, Tom Brereton, Humphrey Q P Crick, Simon J Duffield, Michael D Morecroft, David B Roy
Climate change is increasingly altering the composition of ecological communities, in combination with other environmental pressures such as high-intensity land use. Pressures are expected to interact in their effects, but the extent to which intensive human land use constrains community responses to climate change is currently unclear. A generic indicator of climate change impact, the community temperature index (CTI), has previously been used to suggest that both bird and butterflies are successfully 'tracking' climate change...
January 10, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28068154/adapting-a-computer-delivered-brief-alcohol-intervention-for-veterans-with-hepatitis-c
#10
Michael A Cucciare, Andrea L Jamison, Ann S Combs, Gauri Joshi, Ramsey C Cheung, Catherine Rongey, Joe Huggins, Keith Humphreys
OBJECTIVE: This study adapted an existing computer-delivered brief alcohol intervention (cBAI) for use in Veterans with the hepatitis C virus (HCV) and examined its acceptability and feasibility in this patient population. METHODS: A four-stage model consisting of initial pilot testing, qualitative interviews with key stakeholders, development of a beta version of the cBAI, and usability testing was used to achieve the study objectives. RESULTS: In-depth interviews gathered feedback for modifying the cBAI, including adding HCV-related content such as the health effects of alcohol on liver functioning, immune system functioning, and management of HCV, a preference for concepts to be displayed through "newer looking" graphics, and limiting the use of text to convey key concepts...
January 9, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28068117/the-neural-representation-of-the-gender-of-faces-in-the-primate-visual-system-a-computer-modeling-study
#11
Thomas Minot, Hannah L Dury, Akihiro Eguchi, Glyn W Humphreys, Simon M Stringer
We use an established neural network model of the primate visual system to show how neurons might learn to encode the gender of faces. The model consists of a hierarchy of 4 competitive neuronal layers with associatively modifiable feedforward synaptic connections between successive layers. During training, the network was presented with many realistic images of male and female faces, during which the synaptic connections are modified using biologically plausible local associative learning rules. After training, we found that different subsets of output neurons have learned to respond exclusively to either male or female faces...
January 9, 2017: Psychological Review
https://www.readbyqxmd.com/read/28068060/structural-and-functional-basis-of-c-methylation-of-coumarin-scaffolds-by-novo
#12
Joanna C Sadler, Chun-Wa Chung, Julie E Mosley, Glenn A Burley, Luke D Humphreys
C-methylation of aromatic small molecules by C-methyltransferases (C-MTs) is an important biological trans-formation that involves C-C bond formation using S-adenosyl-L-methionine (SAM) as the methyl donor. Here, two advanc-es in the mechanistic understanding of C-methylation of the 8-position of coumarin substrates catalyzed by the C-MT No-vO from Streptomyces Spheroides are described. First, a crystal structure of NovO reveals the Arg116-Asn117 and His120-Arg121 motifs are essential for coumarin substrate binding...
January 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28057055/functional-characterization-of-plasmodium-berghei-psop25-during-ookinete-development-and-as-a-malaria-transmission-blocking-vaccine-candidate
#13
Wenqi Zheng, Fei Liu, Yiwen He, Qingyang Liu, Gregory B Humphreys, Takafumi Tsuboi, Qi Fan, Enjie Luo, Yaming Cao, Liwang Cui
BACKGROUND: Plasmodium ookinete surface proteins as post-fertilization target antigens are potential malaria transmission-blocking vaccine (TBV) candidates. Putative secreted ookinete protein 25 (PSOP25) is a highly conserved ookinete surface protein, and has been shown to be a promising novel TBV target. Here, we further investigated the TBV activities of the full-length recombinant PSOP25 (rPSOP25) protein in Plasmodium berghei, and characterized the potential functions of PSOP25 during the P...
January 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28056568/in-vitro-metabolite-formation-in-human-hepatocytes-and-cardiomyocytes-and-metabolism-and-tissue-distribution-in-monkeys-of-the-2-c-methylguanosine-prodrug-bms-986094
#14
Wenying Li, Kevin J Trouba, Li Ma, Jae Kwagh, Christopher Storck, Yongxin Zhu, Oliver Flint, William G Humphreys, Jian Wang, Ang Liu, Bonnie Wang, Michael J Graziano, Marc H Davies, Thomas P Sanderson
BMS-986094, a 2'-C-methylguanosine prodrug for the treatment of chronic hepatitis C virus infection, was withdrawn from phase 2 clinical trials because of unexpected cardiac and renal toxicities. To better understand these toxicities, the in vitro metabolism of BMS-986094 in human hepatocytes (HHs) and human cardiomyocytes (HCMs) and the measurement of BMS-986094 and selected metabolites in monkey plasma and tissues were assessed. BMS-986094 was extensively metabolized by HHs and HCMs, resulting in more efficient formation and accumulation of the active triphosphorylated metabolite, INX-09114, and less efficient efflux of metabolites in HCMs...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28056057/flat-anterior-chamber-after-trabeculectomy-in-secondary-angle-closure-glaucoma-with-best1-gene-mutation-case-series
#15
Yimin Zhong, Xinxing Guo, Hui Xiao, Jingyi Luo, Chengguo Zuo, Xiaobo Huang, Jingjing Huang, Lan Mi, Qingjiong Zhang, Xing Liu
PURPOSE: Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive bestrophinopathy (ARB). METHODS: In this retrospective case series study, 8 secondary ACG patients with ARB and their 4 recruited family members underwent a thorough ophthalmic examination including best-corrected visual acuity, Goldmann applanation tonometry, gonioscopy, and fundus examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28055075/oral-pharmacologic-treatment-of-type-2-diabetes-mellitus-a-clinical-practice-guideline-update-from-the-american-college-of-physicians
#16
Amir Qaseem, Michael J Barry, Linda L Humphrey, Mary Ann Forciea
Description: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on oral pharmacologic treatment of type 2 diabetes in adults. This guideline serves as an update to the 2012 ACP guideline on the same topic. This guideline is endorsed by the American Academy of Family Physicians. Methods: This guideline is based on a systematic review of randomized, controlled trials and observational studies published through December 2015 on the comparative effectiveness of oral medications for type 2 diabetes...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28052787/cold-plasma-technology-and-reducing-surface-bacterial-counts-a-pilot-study
#17
Tânia Claro, Roisin Fay, Conor Murphy, Niall O'Connor, Stephen Daniels, Hilary Humphreys
No abstract text is available yet for this article.
January 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28050324/prevalence-of-split-nerve-fiber-layer-bundles-in-healthy-people-imaged-with-spectral-domain-optical-coherence-tomography
#18
Sirel Gür Güngör, Ahmet Akman, Almila Sarıgül Sezenöz, Gülşah Tanrıaşıkı
OBJECTIVES: The presence of retinal nerve fiber layer (RNFL) split bundles was recently described in normal eyes scanned using scanning laser polarimetry and by histologic studies. Split bundles may resemble RNFL loss in healthy eyes. The aim of our study was to determine the prevalence of nerve fiber layer split bundles in healthy people. MATERIALS AND METHODS: We imaged 718 eyes of 359 healthy persons with the spectral domain optical coherence tomography in this cross-sectional study...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28049348/invasive-mrsa-infections-in-neurosurgical-patients-a-decade-of-progress
#19
Mairéad Skally, Caoimhe Finn, David O'Brien, Fidelma Fitzpatrick, Karen Burns, Elaine McFadden, Margaret Fitzpatrick, Edmond Smyth, Hilary Humphreys
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of bloodstream infection (BSI), which is declining in many countries, including Ireland. However, it also causes other invasive infections, such as meningitis in neurosurgical patients. It is unclear whether the decline in MRSA BSI is reflected in other invasive infections and in specialist units. AIM: To investigate trends in the incidence of MRSA invasive infection in a national neurosurgical centre over a 10-year period...
January 3, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28043843/outcomes-of-holep-in-the-retreatment-setting
#20
Tracy Marien, Mustafa Kadihasanoglu, Teerayut Tangpaitoon, Nadya York, Andrew T Blackburne, Haidar Abdul-Muhsin, Michael S Borofsky, Amy E Krambeck, Mitchell R Humphreys, James E Lingeman, Nicole L Miller
INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) can also be applied in the retreatment setting when other BPH therapies fail. We sought to compare outcomes of men undergoing HoLEP in the primary versus retreatment setting (pHoLEP versus rHoLEP). MATERIALS AND METHODS: A retrospective review of 2,242 patients undergoing HoLEP at four academic hospitals between 2003 and 2015 was performed. Patient demographic, operative and perioperative outcomes between rHoLEP and pHoLEP were compared...
December 30, 2016: Journal of Urology
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