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https://www.readbyqxmd.com/read/29470573/factors-associated-with-health-related-quality-of-life-in-medically-and-surgically-treated-patients-with-glaucoma
#1
Cheryl L Khanna, David A Leske, Jonathan M Holmes
Importance: Health-related quality of life (HRQOL) is often reduced with glaucoma, but associated factors are poorly understood. Objective: To determine factors associated with reduced HRQOL in medically and surgically treated patients with glaucoma. Design, Setting, and Participants: Prospective cohort study at a tertiary referral glaucoma practice, with 160 consecutive, prospectively enrolled medically or surgically treated adult patients with glaucoma...
February 22, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29469197/physiologically-based-pharmacokinetic-modeling-of-a-cyp2c19-substrate-bms-823778-utilizing-pharmacogenetic-data
#2
Jiachang Gong, Lisa Iacono, Ramaswamy A Iyer, W Griffith Humphreys, Ming Zheng
AIMS: Previous studies demonstrated direct correlation between CYP2C19 genotype and BMS-823778 clearance in healthy volunteers. The objective of the present study was to develop a PBPK model for BMS-823778 and utilize the model to predict PK and DDI in virtual populations with multiple polymorphic genes. METHODS: The PBPK model was built and verified utilizing existing clinical data. The verified model was simulated to predict PK of BMS-823778 and significance of DDI with a strong CYP3A4 inhibitor in subjects with various CYP2C19 and UGT1A4 genotypes...
February 22, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29468760/it-is-premature-to-expand-access-to-medicinal-cannabis-in-hopes-of-solving-the-us-opioid-crisis
#3
EDITORIAL
Wayne Hall, Robert West, John Marsden, Keith Humphreys, Jo Neale, Nancy Petry
No abstract text is available yet for this article.
February 22, 2018: Addiction
https://www.readbyqxmd.com/read/29466163/our-other-prescription-drug-problem
#4
Anna Lembke, Jennifer Papac, Keith Humphreys
No abstract text is available yet for this article.
February 22, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29464923/effect-of-acute-hypoxemia-on-cerebral-blood-flow-velocity-control-during-lower-body-negative-pressure
#5
Noud van Helmond, Blair D Johnson, Walter W Holbein, Humphrey G Petersen-Jones, Ronée E Harvey, Sushant M Ranadive, Jill N Barnes, Timothy B Curry, Victor A Convertino, Michael J Joyner
The ability to maintain adequate cerebral blood flow and oxygenation determines tolerance to central hypovolemia. We tested the hypothesis that acute hypoxemia during simulated blood loss in humans would cause impairments in cerebral blood flow control. Ten healthy subjects (32 ± 6 years, BMI 27 ± 2 kg·m-2 ) were exposed to stepwise lower body negative pressure (LBNP, 5 min at 0, -15, -30, and -45 mmHg) during both normoxia and hypoxia (Fi O2 = 0.12-0.15 O2 titrated to an SaO2 of ~85%). Physiological responses during both protocols were expressed as absolute changes from baseline, one subject was excluded from analysis due to presyncope during the first stage of LBNP during hypoxia...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29464066/near-infrared-fluorescence-imaging-of-egfr-expression-in-vivo-using-irdye800cw-nimotuzumab
#6
Wendy Bernhard, Ayman El-Sayed, Kris Barreto, Carolina Gonzalez, Wayne Hill, Angel Casaco Parada, Humphrey Fonge, C Ronald Geyer
Nimotuzumab is a humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody that is approved in many countries for the treatment of EGFR-positive cancers. Near infrared (NIR) fluorescent dye-labeled antibodies represent an attractive class of image-guided surgical probes because of their high specificity, tumor uptake, and low dissociation from tumor cells that express the antigen. In this study, we developed a NIR fluorescent dye-labeled nimotuzumab immunoconjugate, IRDye800CW-nimotuzumab, and evaluated in vitro binding with EGFR-positive cells, in vivo tumor uptake by NIR fluorescent imaging, and ex vivo biodistribution...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463961/comparison-of-chiropractic-treatment-outcomes-depending-on-the-language-region-in-switzerland-a-prospective-outcomes-study
#7
David A Guillén, Cynthia K Peterson, B Kim Humphreys
Objectives: Switzerland has optimal conditions for research of language-based cultural influences on low back pain (LBP). The aim of this study was to compare LBP treatment outcomes after chiropractic care between patients from the German- and French-speaking regions of Switzerland. Methods: Baseline Numeric Rating Scale for pain (NRS), demographic, and Oswestry Disability Index (ODI) data were collected from patients presenting to 51 Swiss-German and 12 Swiss-French chiropractors...
December 2017: Journal of Chiropractic Humanities
https://www.readbyqxmd.com/read/29455047/prospective-cohort-study-of-neoadjuvant-therapy-toxicity-in-the-treatment-of-oesophageal-adenocarcinoma
#8
David Bunting, Richard Berrisford, Tim Wheatley, Lee Humphreys, Arun Ariyarathenam, Grant Sanders
BACKGROUND: Early studies investigating the benefits of neoadjuvant therapy in oesophageal cancer showed conflicting results, taking many years before a survival advantage was demonstrated in randomised trials. Gains are modest, limited by progressive disease and toxicity. This study aimed to investigate the relationship between neoadjuvant therapy-associated toxicity and clinical outcomes including survival in patients with potentially curable oesophageal adenocarcinoma. MATERIALS AND METHODS: A cohort of 286 patients undergoing neoadjuvant therapy followed by surgical resection at a single institution was identified from a prospective database...
February 15, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29451998/predicting-the-integrated-visual-field-with-wide-scan-optical-coherence-tomography-in-glaucoma-patients
#9
Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa
PURPOSE: This study aimed to calculate a predicted integrated visual field (IVF) based on predicted monocular visual fields (MVFs) derived, with a new method, from wide-scan optical coherence tomography (OCT) data. MATERIALS AND METHODS: Visual field testing used the central (6 × 4) 24 points of the Humphrey Field Analyzer 24-2 program. OCT scans of a corresponding retinal area, centered on the fovea, were divided into a 6 × 4 grid. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCIPL), and mRNFL + GCIPL (GCC) was measured in each grid area...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29450914/graphene-and-carbon-nanotube-nanohybrids-covalently-functionalized-by-porphyrins-and-phthalocyanines-for-optoelectronic-properties
#10
REVIEW
Aijian Wang, Jun Ye, Mark G Humphrey, Chi Zhang
In recent years, there has been a rapid growth in studies of the optoelectronic properties of graphene, carbon nanotubes (CNTs), and their derivatives. The chemical functionalization of graphene and CNTs is a key requirement for the development of this field, but it remains a significant challenge. The focus here is on recent advances in constructing nanohybrids of graphene or CNTs covalently linked to porphyrins or phthalocyanines, as well as their application in nonlinear optics. Following a summary of the syntheses of nanohybrids constructed from graphene or CNTs and porphyrins or phthalocyanines, explicit intraconjugate electronic interactions between photoexcited porphyrins/phthalocyanines and graphene/CNTs are introduced classified by energy transfer, electron transfer, and charge transfer, and their optoelectronic applications are also highlighted...
February 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29450401/non-parametric-tests-in-detecting-glaucoma-progression
#11
Anca Pantalon, Crenguța Feraru
Automated perimetry still represents the gold standard in long term glaucoma monitoring. On a daily practice basis, glaucoma progression analysis could be difficult due to the long time needed to detect, confirm, and quantify the progression rate. Moreover, "trend" and "event" analysis require a good theoretical basis to perform and interpret. Aim of study was to present an alternative method to conventional Glaucoma Progression Analysis (Humphrey Visual Field Analyzer, Carl Zeiss® Inc...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29448909/a-preliminary-investigation-into-a-range-of-implicit-and-explicit-offense-supportive-cognitions-in-perpetrators-of-physical-intimate-partner-violence
#12
Chrisa D Pornari, Louise Dixon, Glyn W Humphreys
The current study assessed a wide range of offense supportive cognitions in relation to the perpetration of physical intimate partner violence (IPV). This research used both implicit and explicit measures in a U.K. sample of 19 male IPV perpetrators recruited from a community-based IPV intervention program and 20 men from the community with no history of IPV. The study also explored the ability of the implicit measures to differentiate between the two groups. The cognitions assessed included gender-role stereotype, attitudes condoning violence against a partner, attitudes condoning violence in general, hostile attitudes toward women, sense of entitlement in the relationship and over the intimate partner (control and dominance), and general sense of entitlement...
February 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29448009/openstreetmap-data-for-alcohol-research-reliability-assessment-and-quality-indicators
#13
Jonathan Bright, Stefano De Sabbata, Sumin Lee, Bharath Ganesh, David K Humphreys
There is a growing interest in using OpenStreetMap [OSM] data in health research. We evaluate the usefulness of OSM data for researching the spatial availability of alcohol, a field which has been hampered by data access difficulties. We find OSM data is about 50% complete, which appears adequate for replicating findings from other studies using alcohol licensing data. Further, we show how OSM quality metrics can be used to select areas with more complete alcohol data. The ease of access and use may create opportunities for analysts and researchers seeking to understand broad patterns of alcohol availability...
February 12, 2018: Health & Place
https://www.readbyqxmd.com/read/29442245/retrobulbar-and-intraocular-blood-flow-in-anterior-ischaemic-optic-neuropathy-are-linked-to-the-functional-impairment
#14
David Kuerten, Matthias Fuest, Marion Bienert, Niklas Plange
PURPOSE: Evaluation of ocular haemodynamics in patients with acute non-arteritic anterior ischaemic optic neuropathy (NAION) by colour Doppler imaging and fluorescein angiography and correlation of blood flow parameters to visual field loss and visual acuity. METHODS: Blood flow velocities (peak systolic velocity (PSV), end-diastolic velocity (EDV)) of the ophthalmic artery (OA), central retinal artery (CRA) and nasal and temporal posterior ciliary arteries (PCAs) were measured via colour Doppler imaging...
February 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29440866/long-term-progression-of-visual-field-defects-and-related-factors-in-medically-treated-normal-tension-glaucoma
#15
Keiji Yoshikawa, Kazunori Santo, Hiroko Hizaki, Masayo Hashimoto
Purpose: To analyze factors related to long-term progression of visual field defects (VFD) in patients with normal tension glaucoma (NTG) under medical therapy. Patients and methods: Clinical data from 622 eyes of 311 primary open-angle glaucoma and NTG patients were collected from April 2006 to March 2016. Of these patients, those with normal intraocular pressure (IOP); glaucomatous VFD judged by Anderson's criteria; corrected visual acuity ≥0.7; receiving more than 6 years medical therapy; having undergone ≥10 visual field tests performed at 6-month intervals using a Humphrey field analyzer (Swedish Interactive Threshold Algorithms standard, C 24-2 program); and having reliability coefficients of visual field testing <33% and mean deviation (MD) more than -20 decibels in the initial visual field test were included in data analysis...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29439358/improvement-in-activities-of-daily-living-after-visual-training-in-patients-with-homonymous-visual-field-defects-using-goal-attainment-scaling
#16
Joris A Elshout, Douwe P Bergsma, Jacqueline Sibbel, Annette Baars-Elsinga, Paula Lubbers, Freekje Van Asten, Johanna Visser-Meily, Albert V Van Den Berg
BACKGROUND: Stroke is the most common cause of homonymous visual field defects (HVFDs). Yet, there is no standard protocol for composing a rehabilitation program. OBJECTIVE: In this study we assess ADL gain of visual training for vision restoration in HVFD patients by means of Goal Attainment Scaling. METHODS: Thirty-five patients trained two predefined regions of the visual field successively at home. In each region we compared the effects of both training rounds, one of which was thus 'directed' and the other 'undirected'...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29438452/early-life-predictors-of-future-multi-morbidity-results-from-the-hertfordshire-cohort
#17
Jenny Humphreys, Karen Jameson, Cyrus Cooper, Elaine Dennison
Background: multi-morbidity is an increasing challenge in western medicine and has the potential to impact patients' quality of life, treatment options and compliance with medications. The aim of this study was to identify the early-life predictors of long-term multi-morbidity in an historical cohort, the Hertfordshire Cohort Study (HCS). Methods: perinatal and infant health records were kept on all children born in Hertfordshire between 1931 and 1939. Participants who were still alive in 1998 were recruited to the HCS and data collected on major chronic diseases...
February 9, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29433472/factors-associated-with-developing-a-fear-of-falling-in-subjects-with-primary-open-angle-glaucoma
#18
Sayaka Adachi, Kenya Yuki, Sachiko Awano-Tanabe, Takeshi Ono, Daisuke Shiba, Hiroshi Murata, Ryo Asaoka, Kazuo Tsubota
BACKGROUND: To investigate the relationship between clinical risk factors, including visual field (VF) defects and visual acuity, and a fear of falling, among patients with primary open-angle glaucoma (POAG). METHODS: All participants answered the following question at a baseline ophthalmic examination: Are you afraid of falling? The same question was then answered every 12 months for 3 years. A binocular integrated visual field was calculated by merging a patient's monocular Humphrey field analyzer VFs, using the 'best sensitivity' method...
February 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29431029/oversized-biodegradable-arterial-grafts-promote-enhanced-neointimal-tissue-formation
#19
Cameron A Best, Takuma Fukunishi, Joseph Drews, Ramak Khosravi, Kan Hor, Nathan Mahler, Tai Yi, Jay D Humphrey, Jed Johnson, Christopher K Breuer, Narutoshi Hibino
Most tissue-engineered arterial grafts are complicated by aneurysmal dilation secondary to insufficient neotissue formation after scaffold degradation. The optimal graft would form an organized multi-layered structure with a robust extracellular matrix that could withstand arterial pressure. The purpose of the current study was to determine how oversizing a biodegradable arterial scaffold affects long-term neotissue formation. Size-matched (1.0 mm, n=11) and oversized (1.6 mm, n=9) electrospun polycaprolactone/chitosan scaffolds were implanted as abdominal aortic interposition grafts in Lewis rats...
February 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29428947/a-combination-of-the-aerosolized-ppar-%C3%AE-agonist-pioglitazone-and-a-synthetic-surfactant-protein-b-peptide-mimic-prevents-hyperoxia-induced-neonatal-lung-injury-in-rats
#20
Reiko Sakurai, Cindy Lee, Humphrey Shen, Alan J Waring, Frans J Walther, Virender K Rehan
BACKGROUND: Despite improvements in perinatal care, bronchopulmonary dysplasia (BPD) in extremely premature infants has not decreased. Postnatal surfactant therapy provides symptomatic relief from respiratory distress syndrome, but does not translate into a reduction in BPD. Therefore, the search for effective interventions to prevent BPD continues. OBJECTIVES: Since PPAR-γ agonists have been demonstrated to promote neonatal lung maturation and injury repair, we hypothesized that a formulation of a PPAR-γ agonist, pioglitazone (PGZ) and a synthetic lung surfactant (a surfactant protein B peptide mimic, B-YL) combined would stimulate lung maturation and block hyperoxia-induced neonatal lung injury more effectively than either modality alone...
February 9, 2018: Neonatology
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