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https://www.readbyqxmd.com/read/27913418/a-novel-rhamnose-rich-hetero-exopolysaccharide-isolated-from-lactobacillus-paracasei-dg-activates-thp-1-human-monocytic-cells
#1
Silvia Balzaretti, Valentina Taverniti, Simone Guglielmetti, Walter Fiore, Mario Minuzzo, Hansel N Ngo, Judith B Ngere, Sohaib Sadiq, Paul N Humphreys, Andrew P Laws
: Lactobacillus paracasei DG is a bacterial strain with recognized probiotic properties and is used in commercial probiotic products. However, the mechanisms underlying its probiotic properties are mainly unknown. In this study, we tested the hypothesis that the capability of strain DG to interact with the host is, at least partly, associated with its ability to synthesize a surface-associated exopolysaccharide (EPS). Comparative genomics revealed the presence of putative EPS gene clusters in DG genome; accordingly, EPS was isolated from the surface of the bacterium...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27913141/acute-lung-injury-and-persistent-small-airway-disease-in-a-rabbit-model-of-chlorine-inhalation
#2
Sadiatu Musah, Connie F Schlueter, David M Humphrey, Karen S Powell, Andrew M Roberts, Gary W Hoyle
Chlorine is a pulmonary toxicant to which humans can be exposed through accidents or intentional releases. Acute effects of chlorine inhalation in humans and animal models have been well characterized, but less is known about persistent effects of acute, high-level chlorine exposures. In particular, animal models that reproduce the long-term effects suggested to occur in humans are lacking. Here, we report the development of a rabbit model in which both acute and persistent effects of chlorine inhalation can be assessed...
November 29, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27909403/cortical-sensorimotor-processing-of-painful-pressure-in-patients-with-chronic-lower-back-pain-an-optical-neuroimaging-study-using-fnirs
#3
Andrea Vrana, Michael L Meier, Sabina Hotz-Boendermaker, Barry K Humphreys, Felix Scholkmann
In this study we investigated sensorimotor processing of painful pressure stimulation on the lower back of patients with chronic lower back pain (CLBP) by using functional near-infrared spectroscopy (fNIRS) to measure changes in cerebral hemodynamics and oxygenation. The main objectives were whether patients with CLBP show different relative changes in oxy- and deoxyhemoglobin ([O2Hb] and [HHb]) in the supplementary motor area (SMA) and primary somatosensory cortex (S1) compared to healthy controls (HC). Twelve patients with CLBP (32 ± 6...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27908999/draft-genome-sequence-of-a-multiresistant-bovine-isolate-of-staphylococcus-lentus-from-tanzania
#4
Jeremiah Seni, Stephen E Mshana, Felician Msigwa, Mecky Matee, Humphrey Mazigo, Julian Parkhill, Mark A Holmes, Gavin K Paterson
We report here the draft genome sequence of a Staphylococcus lentus isolate, 050AP, collected in Tanzania from a swab of healthy bovine perineum. The draft genome sequence contained 2.72 Mbp and 2,750 coding sequences with a G+C content of 31.7%.
December 1, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27906045/smoking-is-associated-with-the-concurrent-presence-of-multiple-autoantibodies-in-rheumatoid-arthritis-rather-than-with-anti-citrullinated-protein-antibodies-per-se-a-multicenter-cohort-study
#5
Tineke J van Wesemael, Sofia Ajeganova, Jennifer Humphreys, Chikashi Terao, Ammar Muhammad, Deborah P M Symmons, Alex J MacGregor, Ingiäld Hafström, Leendert A Trouw, Annette H M van der Helm-van Mil, Tom W J Huizinga, Tsuneyo Mimori, René E M Toes, Fumihiko Matsuda, Björn Svensson, Suzanne M M Verstappen, Diane van der Woude
BACKGROUND: The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA). In RA, however, autoantibodies such as ACPA, rheumatoid factor (RF), and anti-carbamylated protein antibodies (anti-CarP) often occur together, and it is thus unclear whether smoking is specifically associated with some autoantibodies rather than others. We therefore investigated whether smoking is only associated with ACPA or with the presence of multiple RA-related autoantibodies...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27906042/what-is-the-impact-of-biologic-therapies-on-common-co-morbidities-in-patients-with-rheumatoid-arthritis
#6
REVIEW
Jenny Humphreys, Kimme Hyrich, Deborah Symmons
Biologic therapies have revolutionised disease control in patients with rheumatoid arthritis (RA). Theoretically, they have the potential to influence co-morbid disease associated with RA through better control of systemic inflammation. Conversely, co-morbidity may occur as an adverse effect of the drugs. The latest evidence from observational data shows an increased risk of infection in the first 6 months of treatment with tumour necrosis factor inhibitor (TNFi) therapies and potentially other biologic therapies...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27905341/heidenhain-variant-of-creutzfeldt-jakob-disease-in-a-patient-who-had-bovine-bioprosthetic-valve-implantation
#7
Jehard Hashoul, Waleed Saliba, Irina Bloch, Haneen Jabaly-Habib
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disorder characterized by rapidly progressing dementia, general neurologic deterioration, and death. When the leading symptoms are visual disturbances, it is termed as the Heidenhain variant of CJD (HvCJD). CJD was reported following prion-contaminated pericardium transplants but never after bovine bioprosthetic cardiac valve. In this case report, we describe HvCJD in a patient who had a bovine bioprosthetic cardiac valve implant. An 82-year-old-woman was referred to neuro-ophthalmology clinic for unexplained visual loss that started 1 month previously...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27905331/prevalent-practice-patterns-in-glaucoma-poll-of-indian-ophthalmologists-at-a-national-conference
#8
Nikhil Shreeram Choudhari, Vanita Pathak-Ray, Sushmita Kaushik, Prateep Vyas, Ronnie George
PURPOSE: The aim of this study is to explore and compare the prevailing practice patterns in the diagnosis and management of glaucoma among subspecialists and general ophthalmologists in India. MATERIALS AND METHODS: This is an interactive audience response system (ARS) based poll of ophthalmologists attending the annual conference of the Glaucoma Society of India in 2013. RESULTS: The information was obtained from 379 ophthalmologists (146 glaucoma specialists, 54 nonglaucoma subspecialists, and 179 general ophthalmologists)...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27905330/screening-for-chloroquine-maculopathy-in-populations-with-uncertain-reliability-in-outcomes-of-automatic-visual-field-testing
#9
Paradee Kunavisarut, Pimploy Chavengsaksongkram, Aniki Rothova, Kessara Pathanapitoon
PURPOSE: The purpose of this study was to compare screening methods for the early detection of maculopathy in patients treated with chloroquine (CQ) or hydroxychloroquine (HCQ) and to identify the risk factors for the development of toxic maculopathy. METHODS: We performed a prospective study of all 217 patients taking CQ and/or HCQ and seen in our center between July 2011 and December 2013. All subjects underwent a complete ocular examination, as well as spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and 10-2 Humphrey visual field (10-2 HVF)...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27902894/the-first-detection-of-ornithobacterium-rhinotracheale-in-new-zealand
#10
H J Ha, N Christensen, S Humphrey, T Haydon, G Bernardi, T Rawdon
Ornithobacterium rhinotracheale (ORT) has been considered exotic to New Zealand and thus, any samples from poultry suspected of ORT infection are submitted as part of an exotic disease investigation managed by Ministry for Primary Industries (MPI) and subjected to standardized test protocols carried out in the physical containment level 3+ laboratory at MPI's Animal Health Laboratory (AHL). All previous exotic disease investigations concerning ORT produced negative results by bacterial culture and conventional PCR...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27898724/risk-factors-for-motor-vehicle-collisions-in-patients-with-primary-open-angle-glaucoma-a-multicenter-prospective-cohort-study
#11
Kenya Yuki, Sachiko Awano-Tanabe, Takeshi Ono, Daisuke Shiba, Hiroshi Murata, Ryo Asaoka, Kazuo Tsubota
PURPOSE: To identify the incidence rate of motor vehicle collisions (MVCs) in patients with no ocular pathology other than primary open-angle glaucoma (POAG) and determine the putative risk factors for MVCs in this group of patients. METHODS: We designed a prospective cohort study across three centers utilizing a consecutive sampling method to identify all patients with POAG between the ages of 40 and 80 years old. Patients with glaucoma were consecutively screened for eligibility...
2016: PloS One
https://www.readbyqxmd.com/read/27894094/met-expression-and-copy-number-status-in-clear-cell-renal-cell-carcinoma-prognostic-value-and-potential-predictive-marker
#12
Stephan Macher-Goeppinger, Martina Keith, Volker Endris, Roland Penzel, Katrin E Tagscherer, Sascha Pahernik, Markus Hohenfellner, Humphrey Gardner, Carsten Grüllich, Peter Schirmacher, Wilfried Roth
Multiple targeted therapy for advanced clear-cell renal cell carcinoma (RCC) has substantially improved patient outcome, but complete remission is uncommon and many tumors eventually develop resistance. Mechanistic, preclinical, and early clinical data highlight c-Met / hepatocyte growth factor receptor as a promising target for RCC therapeutic agents.We have examined MET expression, frequency of MET gene copy gains and MET gene mutation in a large, hospital-based series of renal cell carcinomas with long-term follow-up information...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893769/assessing-visual-fields-in-patients-with-retinitis-pigmentosa-using-a-novel-microperimeter-with-eye-tracking-the-mp-3
#13
Nozomi Igarashi, Masato Matsuura, Yohei Hashimoto, Kazunori Hirasawa, Hiroshi Murata, Tatsuya Inoue, Obata Ryo, Makoto Aihara, Ryo Asaoka
PURPOSE: The purpose of the current study is to investigate the test-retest reproducibility of visual fields (VFs) measured with the MP-3 microperimeter, in patients with retinitis pigmentosa (RP). METHOD: VFs were twice measured with the MP-3 and also the Humphrey Field Analyzer, using the 10-2 test grid pattern in both perimeters, in 30 eyes (15 right and 15 left eyes) of 18 RP patients (11 males and 7 females). Test-retest reproducibility was assessed using the mean absolute deviation (MAD) measure at all 68 points in the test grid...
2016: PloS One
https://www.readbyqxmd.com/read/27893100/do-intense-perimetric-stimuli-saturate-the-healthy-visual-system
#14
Andrew J Anderson, Allison M McKendrick, Andrew Turpin
Purpose: A recent proposal for why glaucomatous perimetric sensitivities of approximately 15 to 19 dB or less are unreliable involves the idea that the neural response of normal retinal ganglion cells saturates for intense perimetric stimuli. A predicted consequence of this saturation is that the neural response for two different high intensity stimuli will be the same, leading to an inability to discriminate between them. We test that prediction. Methods: We used a two-interval forced-choice method of constant stimuli (7 steps, 40 presentations/step) to measure the ability of four healthy observers to discriminate between different intensity Size III perimetric stimuli at 0°, 9°, and 21° eccentricity...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27890924/cellular-plasticity-in-kidney-injury-and-repair
#15
REVIEW
Monica Chang-Panesso, Benjamin D Humphreys
Terminally differentiated cells can be reprogrammed to pluripotency or directly to another differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to in vitro manipulations but rather represents an important aspect of the regenerative response to injury in organs. Differentiated adult cells retain the capacity to dedifferentiate, adopting a progenitor-like phenotype after injury or, alternatively, to transdifferentiate, directly converting to a different mature cell type...
November 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27890098/ballistics-and-anatomical-modelling-a-review
#16
REVIEW
Caitlin Humphrey, Jaliya Kumaratilake
Ballistics is the study of a projectiles motion and can be broken down into four stages: internal, intermediate, external and terminal ballistics. The study of the effects a projectile has on a living tissue is referred to as wound ballistics and falls within terminal ballistics. To understand the effects a projectile has on living tissues the mechanisms of wounding need to be understood. These include the permanent and temporary cavities, energy, yawing, tumbling and fragmenting. Much ballistics research has been conducted including using cadavers, animal models and simulants such as ballistics ordnance gelatine...
November 2016: Legal Medicine
https://www.readbyqxmd.com/read/27888620/identification-of-different-alk-mutations-in-a-pair-of-neuroblastoma-cell-lines-established-at-diagnosis-and-relapse
#17
Lindi Chen, Angharad Humphreys, Lisa Turnbull, Angela Bellini, Gudrun Schleiermacher, Helen Salwen, Susan L Cohn, Nick Bown, Deborah A Tweddle
Anaplastic Lymphoma Kinase (ALK) is a transmembrane receptor kinase that belongs to the insulin receptor superfamily and has previously been shown to play a role in cell proliferation, migration and invasion in neuroblastoma. Activating ALK mutations are reported in both hereditary and sporadic neuroblastoma tumours, and several ALK inhibitors are currently under clinical evaluation as novel treatments for neuroblastoma. Overall, mutations at codons F1174, R1275 and F1245 together account for ~85% of reported ALK mutations in neuroblastoma...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27888090/rationale-and-design-of-mi-care-the-mile-square-colorectal-cancer-screening-awareness-and-referral-and-education-project
#18
Joanna Buscemi, Yazmin San Miguel, Lisa Tussing-Humphreys, Elizabeth A Watts, Marian L Fitzgibbon, Karriem Watson, Robert A Winn, Kameron L Matthews, Yamile Molina
Although colorectal cancer (CRC) is largely preventable through identification of pre-cancerous polyps through various screening modalities, morbidity and mortality rates remain a challenge, especially in African-American, Latino, low-income and uninsured/underinsured patients. Barriers to screening include cost, access to health care facilities, lack of recommendation to screen, and psychosocial factors such as embarrassment, fear of the test, anxiety about testing preparation and fear of a cancer diagnosis...
November 22, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27879525/management-of-patient-experience-with-atx-101-deoxycholic-acid-injection-for-reduction-of-submental-fat
#19
Shannon Humphrey
No abstract text is available yet for this article.
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27876305/new-prostate-cancer-grading-system-predicts-long-term-survival-following-surgery-for-gleason-score-8-10-prostate-cancer
#20
Won Sik Ham, Heather J Chalfin, Zhaoyong Feng, Bruce J Trock, Jonathan I Epstein, Carling Cheung, Elizabeth Humphreys, Alan W Partin, Misop Han
BACKGROUND: The newly proposed five-tiered prostate cancer grading system (PCGS) divides Gleason score (GS) 8-10 disease into GS 8 and GS 9-10 on the basis of biochemical recurrence (BCR) following radical prostatectomy (RP) as an outcome. However, BCR does not necessarily portend worse survival outcomes. OBJECTIVE: To assess the significance of distinguishing GS 8 versus 9-10 disease in terms of long-term survival outcomes for both the preoperative setting using biopsy (Bx) GS and the postoperative setting with RP GS...
November 19, 2016: European Urology
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