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https://www.readbyqxmd.com/read/29156716/using-droplet-digital-pcr-to-analyze-mycn-and-alk-copy-number-in-plasma-from-patients-with-neuroblastoma
#1
Marco Lodrini, Annika Sprüssel, Kathy Astrahantseff, Daniela Tiburtius, Robert Konschak, Holger N Lode, Matthias Fischer, Ulrich Keilholz, Angelika Eggert, Hedwig E Deubzer
The invasive nature of surgical biopsies deters sequential application, and single biopsies often fail to reflect tumor dynamics, intratumor heterogeneity and drug sensitivities likely to change during tumor evolution and treatment. Implementing molecular characterization of cell-free neuroblastoma-derived DNA isolated from blood plasma could improve disease assessment for treatment selection and monitoring of patients with high-risk neuroblastoma. We established droplet digital PCR (ddPCR) protocols for MYCN and ALK copy number status in plasma from neuroblastoma patients...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156285/modelling-spatial-and-temporal-variations-of-annual-suspended-sediment-yields-from-small-agricultural-catchments
#2
A Rymszewicz, M Bruen, J J O'Sullivan, J N Turner, D M Lawler, J R Harrington, E Conroy, M Kelly-Quinn
Estimates of sediment yield are important for ecological and geomorphological assessment of fluvial systems and for assessment of soil erosion within a catchment. Many regulatory frameworks, such as the Convention for the Protection of the Marine Environment of the North-East Atlantic, derived from the Oslo and Paris Commissions (OSPAR) require reporting of annual sediment fluxes. While they may be measured in large rivers, sediment flux is rarely measured in smaller rivers. Measurements of sediment transport at a national scale can be also challenging and therefore, sediment yield models are often utilised by water resource managers for the predictions of sediment yields in the ungauged catchments...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156248/the-symbolic-violence-of-outbreak-a-mixed-methods-quasi-experimental-impact-evaluation-of-social-protection-on-ebola-survivor-wellbeing
#3
Eugene T Richardson, J Daniel Kelly, Osman Sesay, Michael D Drasher, Ishaan K Desai, Raphael Frankfurter, Paul E Farmer, Mohamed Bailor Barrie
Despite over 28,000 reported cases of Ebola virus disease (EVD) in the 2013-16 outbreak in West Africa, we are only beginning to trace the complex biosocial processes that have promoted its spread. Important questions remain, including the effects on survivors of clinical sequelae, loss of family and livelihood, and other psychological and social trauma. Another poorly understood question is what effect social protection and job creation programs have had on survivors' wellbeing. Several clinical and social protection programs have been developed to respond to the needs of EVD survivors; however, little in the way of impact evaluation has taken place...
November 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29156151/limited-evidence-of-fungicide-driven-triazole-resistant-i-aspergillus-fumigatus-i-in-hamilton-canada
#4
Eta Ashu, Ga Young Kim, Patrick Roy-Gayos, Kelly Dong, Adrian Forsythe, Victoria Giglio, Gregory Korfanty, Deborah Yamamura, Jianping Xu
Aspergillus fumigatus is a ubiquitous opportunistic fungal pathogen that can cause aspergillosis in humans. Over the last decade there have been increasing global reports of treatment failure due to triazole resistance. An emerging hypothesis states that agricultural triazole fungicide use causes clinical triazole-resistance. Here we test this hypothesis in Hamilton, Ontario, Canada by examining a total of 195 agricultural, urban and clinical isolates using 9 highly polymorphic microsatellite markers. For each isolate, the in vitro susceptibilities to itraconazole and voriconazole, two triazole drugs commonly used in the management of patients, were also determined...
November 20, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29156016/pectus-excavatum-repair-after-sternotomy-the-chest-wall-international-group-experience-with-substernal-nuss-bars
#5
Dawn E Jaroszewski, Paul J Gustin, Frank-Martin Haecker, Hans Pilegaard, Hyung Joo Park, Shao-Tao Tang, Shuai Li, Li Yang, Sadashige Uemura, Jose Ribas Milanez De Campos, Robert Obermeyer, Frazier W Frantz, Michele Torre, Lisa McMahon, Andre Hebra, Chih-Chun Chu, J Duncan Phillips, David M Notrica, Antonio Messineo, Robert Kelly, Mustafa Yüksel
OBJECTIVES: Patients with pectus excavatum (PE) after prior sternotomy for cardiac surgery present unique challenges for repair of PE. Open repairs have been recommended because of concerns about sternal adhesions and cardiac injury. We report a multi-institutional experience with repair utilizing substernal Nuss bars in this patient population. METHODS: Surgeons from the Chest Wall International Group were queried for experience and retrospective data on PE repair using sub-sternal Nuss bars in patients with a history of median sternotomy for cardiac surgery (November 2000 to August 2015)...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155751/dissection-and-immunofluorescent-staining-of-mushroom-body-and-photoreceptor-neurons-in-adult-drosophila-melanogaster-brains
#6
Seth M Kelly, Alexandra Elchert, Michael Kahl
Nervous system development involves a sequential series of events that are coordinated by several signaling pathways and regulatory networks. Many of the proteins involved in these pathways are evolutionarily conserved between mammals and other eukaryotes, such as the fruit fly Drosophila melanogaster, suggesting that similar organizing principles exist during the development of these organisms. Importantly, Drosophila has been used extensively to identify cellular and molecular mechanisms regulating processes that are required in mammals including neurogenesis, differentiation, axonal guidance, and synaptogenesis...
November 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155210/transition-from-androgenic-to-neurosteroidal-action-of-5%C3%AE-androstane-3%C3%AE-17%C3%AE-diol-through-the-type-a-%C3%AE-aminobutyric-acid-receptor-in-prostate-cancer-progression
#7
Ding Xia, Doan V Lai, Weijuan Wu, Zachary D Webb, Qing Yang, Lichao Zhao, Zhongxin Yu, Jessica E Thorpe, Bryan C Disch, Michael A Ihnat, Muralidharan Jayaraman, Danny N Dhanasekaran, Kelly L Stratton, Michael S Cookson, Kar-Ming Fung, Hsueh-Kung Lin
Androgen ablation is the standard of care prescribed to patients with advanced or metastatic prostate cancer (PCa) to slow down disease progression. Unfortunately, a majority of PCa patients under androgen ablation progress to castration-resistant prostate cancer (CRPC). Several mechanisms including alternative intra-prostatic androgen production and androgen-independent androgen receptor (AR) activation have been proposed for CRPC progression. Aldo-keto reductase family 1 member C3 (AKR1C3), a multi-functional steroid metabolizing enzyme, is specifically expressed in the cytoplasm of PCa cells; and positive immunoreactivity of the type A γ-aminobutyric acid receptor (GABAAR), an ionotropic receptor and ligand-gated ion channel, is detected on the membrane of PCa cells...
November 15, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29155145/differential-effects-of-the-nrf2-activators-tbhq-and-cddo-im-on-the-early-events-of-t-cell-activation
#8
Joseph W Zagorski, Alexandra E Turley, Robert A Freeborn, Kelly R VanDenBerg, Heather E Dover, Brian R Kardell, Karen T Liby, Cheryl E Rockwell
We previously demonstrated that activation of the transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) promotes CD4+ Th2 differentiation. In the current study, we assessed the role of Nrf2 in early events following T cell activation. The Nrf2 activators, tBHQ (tert-butylhydroquinone) and CDDO-Im (the imidazolide derivative of the triterpenoid CDDO), were used in conjunction with splenocytes derived from wild-type and Nrf2-null mice to distinguish between Nrf2-specific and off-target effects...
November 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29154970/patient-engagement-using-new-technology-to-improve-adherence-to-positive-airway-pressure-therapy-a-retrospective-analysis
#9
Atul Malhotra, Maureen E Crocker, Leslee Willes, Colleen Kelly, Sue Lynch, Adam V Benjafield
BACKGROUND: Sleep apnea has major neurocognitive and cardiovascular and metabolic risks. Treatment of sleep apnea is sub-optimal because of variable adherence to existing therapies. METHODS: This trial compared PAP adherence among patients who were provided active patient engagement (APE) technology versus those who received usual care monitoring (UCM). The primary outcome was defined by the U.S. Medicare definition of adherence. PARTICIPANTS: Adherence data from two cloud-based databases (AirView™ and myAir™) were analyzed for patients with sleep apnea...
November 15, 2017: Chest
https://www.readbyqxmd.com/read/29154962/a-novel-type-2-diabetes-mouse-model-of-combined-diabetic-kidney-disease-and-atherosclerosis
#10
Karin E Bornfeldt, Farah Kramer, Anna Batorsky, Jinkuk Choi, Kelly L Hudkins, Peter Tontonoz, Charles E Alpers, Jenny E Kanter
Diabetic kidney disease and atherosclerotic disease are major causes of morbidity and mortality associated with type 2 diabetes (T2D), and diabetic kidney disease is a major cardiovascular risk factor. The BTBR mouse strain with leptin-deficiency (Lep(ob)) has emerged as one of the best models of human diabetic kidney disease. However, no T2D mouse model of combined diabetic kidney disease and atherosclerosis exists. Our goal was to generate such a model. To this end, the LDL receptor was targeted for degradation via IDOL (inducible degrader of the LDL receptor) overexpression, using a liver-targeted adeno-associated virus (AAV-DJ/8) in BTBR wild-type (WT) and BTBR Lep(ob) (OB) mice...
November 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29154933/opioid-prescription-and-patient-use-following-gynecologic-procedures-a-survey-of-patients-and-providers
#11
Kendall C Griffith, Nisse V Clark, Andrea L Zuckerman, Tanaz R Ferzandi, Kelly N Wright
STUDY OBJECTIVE: To describe opioid distribution and patient use following gynecologic procedures. DESIGN: This is a survey study of physicians and patients composed of two parts: 1) a physician survey on opioid prescribing practices following gynecologic procedures, and 2) a patient survey on opioid consumption following hysterectomy. DESIGN CLASSIFICATION: III SETTING: An urban academic tertiary care hospital. SUBJECTS: 96 gynecologists in the Boston-area...
November 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29154842/delay-in-an-eating-disorder-diagnosis-the-reason-was-a-shox
#12
Amy B Middleman, Sara Reed, Kelly A Curran
BACKGROUND: Patients' underlying medical conditions may impact the presentation and progression of an eating disorder. CASE: We describe a patient with an undiagnosed, rare, genetic skeletal dysplasia with effects on body mass index that likely led to body image distortion and delayed the diagnosis of an eating disorder. SUMMARY: It is critical to assess disordered eating fully in the context of each patient's clinical status.
November 14, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29154779/letrozole-pre-treatment-prior-to-medical-termination-of-pregnancy-a-systematic-review
#13
Christopher M Nash, Lauren Philp, Prakesh Shah, Kellie E Murphy
OBJECTIVE(S): The purpose of this systematic review was to evaluate the efficacy of pretreatment with letrozole prior to either a first or second trimester medical termination of pregnancy. STUDY DESIGN: We searched letrozole, femara, aromatase inhibitors, abortifacient agents, termination of pregnancy, and labour induction in MEDLINE, EMBASE, Cochrane Database, Google Scholar, and PubMed from inception of each database until September 2015 with no language limitation...
November 14, 2017: Contraception
https://www.readbyqxmd.com/read/29154404/diabetes-news
#14
Ann M Carracher, Payal H Marathe, Kelly L Close
The 20th annual Diabetes Canada Professional Conference took place in November 2017 in Edmonton, Alberta, Canada, featuring Dr Daniel Drucker on 30 years of incretin biology research and Dr David Matthews on implications of the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS) trial,(1) among other sessions.
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29154261/electrical-impedance-of-the-torso-is-associated-with-the-pressure-pain-threshold-on-myofascial-trigger-points-in-patients-with-chronic-neck-pain-a-cross-sectional-study
#15
Almir Vieira Dibai-Filho, Marília Artese Barros, Alessandra Kelly de Oliveira, Rinaldo Roberto de Jesus Guirro
BACKGROUND: Myofascial trigger points are dysfunctional structures present in skeletal muscles and are related to sensory, motor, and autonomic changes. Despite scientific advances in recent decades in the measurement of musculoskeletal pain, evaluation of this clinical phenomenon is supported with instruments that, although valid and reliable, have a considerable degree of subjectivity. OBJECTIVE: To correlate electrical impedance of the upper limbs and torso with pain intensity, functional capacity, catastrophizing, pressure pain threshold, and skin temperature on myofascial trigger points in the upper trapezius muscle of patients with neck pain...
November 10, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29154148/the-relationship-between-executive-functions-and-emotion-regulation-in-females-attending-therapeutic-community-treatment-for-substance-use-disorder
#16
Ely M Marceau, Peter J Kelly, Nadia Solowij
BACKGROUND: Difficulties in emotion regulation influence the development of substance use disorder (SUD), its severity, course, treatment outcomes, and relapse. Impaired executive functions (EFs) are common in SUD populations and may relate to emotion dysregulation. The current study tested whether performance on three basic EF tasks ('working memory', 'inhibition', and 'task-switching') and/or inventory-based assessment of EF were related to difficulties in emotion regulation in females attending residential SUD therapeutic community treatment...
November 12, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29154144/multi-platform-omics-analysis-of-human-ebola-virus-disease-pathogenesis
#17
Amie J Eisfeld, Peter J Halfmann, Jason P Wendler, Jennifer E Kyle, Kristin E Burnum-Johnson, Zuleyma Peralta, Tadashi Maemura, Kevin B Walters, Tokiko Watanabe, Satoshi Fukuyama, Makoto Yamashita, Jon M Jacobs, Young-Mo Kim, Cameron P Casey, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Marina A Gritsenko, Matthew E Monroe, Karl K Weitz, Anil K Shukla, Mingyuan Tian, Gabriele Neumann, Jennifer L Reed, Harm van Bakel, Thomas O Metz, Richard D Smith, Katrina M Waters, Alhaji N'jai, Foday Sahr, Yoshihiro Kawaoka
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD pathophysiology, we performed multi-platform 'omics analysis of peripheral blood mononuclear cells and plasma from EVD patients. Our results indicate that EVD molecular signatures overlap with those of sepsis, imply that pancreatic enzymes contribute to tissue damage in fatal EVD, and suggest that Ebola virus infection may induce aberrant neutrophils whose activity could explain hallmarks of fatal EVD...
November 15, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29154064/living-with-chronic-pain-evaluating-patient-experiences-with-a-medical-group-visit-focused-on-mindfulness-and-non-pharmacological-strategies
#18
Anna Sophia Lestoquoy, Lance D Laird, Suzanne Mitchell, Katherine Gergen-Barnett, N Lily Negash, Kelly McCue, Racquel Enad, Paula Gardiner
OBJECTIVES: Little is known about the acceptance of non-pharmacological group strategies delivered to low income racially diverse patients with chronic pain and depression. This paper examines how the Integrative Medical Group Visit (IMGV) addresses many of the deficits identified with usual care. DESIGN AND SETTING: Six IMGVs cohorts were held at a safety net hospital and two federally funded community health centres. Data was gathered through focus groups. Transcripts were analysed using both a priori codes and inductive coding...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29154017/patient-attitudes-and-experiences-that-predict-medication-discontinuation-in-the-veterans-health-administration
#19
Amy Linsky, Steven R Simon, Kelly Stolzmann, Mark Meterko
OBJECTIVES: Polypharmacy is associated with adverse medication effects. One potential solution is deprescribing, which is the intentional, proactive, rational discontinuation of a medication that is no longer indicated or for which the potential harms outweigh the potential benefits. We identified patient characteristics, attitudes, and health care experiences associated with medication discontinuation. DESIGN, SETTING, AND PARTICIPANTS: We conducted a national mail survey, with the use of the Patient Perceptions of Discontinuation (PPoD) instrument, of 1600 veterans receiving primary care at Veterans Affairs (VA) medical centers and prescribed 5 or more concurrent medications...
November 16, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29153940/tumor-derived-cytokines-impair-myogenesis-and-alter-the-skeletal-muscle-immune-microenvironment
#20
Kelly A Hogan, Dong Seong Cho, Paige C Arneson, Adrienne Samani, Patrick Palines, Yanan Yang, Jason D Doles
Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an incomplete understanding of the role of tumor-derived factors in muscle wasting and sparse knowledge of how these factors impact in vivo muscle regeneration. Here, we identify several cytokines/chemokines that negatively impact in vitro myogenic differentiation...
November 16, 2017: Cytokine
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