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https://www.readbyqxmd.com/read/29786947/does-general-experience-affect-self-assessment
#1
Parisa Rezaiefar, Kelly Forse, Joseph K Burns, Sharon Johnston, Elizabeth Muggah, Claire Kendall, Douglas Archibald
BACKGROUND: The assessment of clinical competence is critical in medical education. Understanding the effect of general experience on a physician's self-assessment would help design more effective curricula and evaluations of procedural skills in postgraduate training and continuing professional development (CPD). In this observational study, we assessed the effect of general experience on the correlation between confidence and competence amongst experienced clinicians (ECs) and postgraduate trainees (PGTs) when learning an office-based procedure in pessary care...
May 22, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29786898/adults-with-comorbid-posttraumatic-stress-disorder-alcohol-use-disorder-and-opioid-use-disorder-the-effectiveness-of-modified-prolonged-exposure
#2
Kelly R Peck, Julie A Schumacher, Paul R Stasiewicz, Scott F Coffey
Opioid use disorders (OUDs) are a growing problem in the United States. When OUDs co-occur with problematic drinking and posttraumatic stress disorder (PTSD), negative drug-related mental and physical health outcomes may be exacerbated. Thus, it is important to establish whether PTSD treatments with established efficacy for dually diagnosed individuals also demonstrate efficacy in individuals who engage in problematic drinking and concurrent opioid misuse. Adults who met DSM-IV-TR criteria for PTSD and alcohol dependence were recruited from a substance use treatment facility and were randomly assigned to receive either modified prolonged exposure (mPE) therapy for PTSD or a non-trauma-focused comparison treatment...
May 22, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29785789/american-college-of-cardiology-2018
#3
Ann M Carracher, Payal H Marathe, Kelly L Close
Ann M. Carracher, Payal H. Marathe, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Carracher, Marathe, and Close review the latest developments relevant to researchers and clinicians.
May 21, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29785628/gut-associated-bacteria-of-helicoverpa-zea-indirectly-trigger-plant-defenses-in-maize
#4
Jie Wang, Mingyu Yang, Yuanyuan Song, Flor E Acevedo, Kelli Hoover, Rensen Zeng, Gary W Felton
Insect-associated microbes can contribute to the physiological and ecological functions of insects. Despite a few examples in beetles and piercing-sucking insects, the varied mechanisms of how insect-associated bacteria mediate plant-insect interactions are still not fully understood. The polyphagous herbivore Helicoverpa zea is a major agricultural pest that harbors certain microbes in their digestive systems. Enterobacter ludwigii is one of the gut-associated bacteria identified from field-collected caterpillars, and it has been shown to indirectly induce defenses in the dicot plant tomato by triggering the biosynthesis of salivary elicitors, but there are no clear mechanisms to show how gut microbes alter these salivary cues and how a different host plant responds to these inducible elicitors...
May 22, 2018: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29785062/outcomes-of-hypoxic-respiratory-failure-at-birth-associated-with-previable-rupture-of-membranes
#5
Michelle Baczynski, Shannon Ginty, Dany Weisz, Patrick J McNamara, Edmond Kelly, Prakesh S Shah, Amish Jain
OBJECTIVE: To characterize clinical outcomes of infants born after previable rupture of membranes (pROM, < 23 weeks gestation and latency period ≥ 2 weeks) in relation to refractory hypoxic respiratory failure (rHRF). STUDY DESIGN: pROM neonates categorized as rHRF (FiO2  > 0.6 for ≥ 2 h) and treated (high frequency ventilation + inhaled nitric oxide) were compared with no rHRF group. Primary outcome was survival until discharge. Factors associated with rHRF and mortality were identified...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29784616/seizures-antiepileptic-drugs-and-ckd
#6
REVIEW
Victoria Títoff, Heather N Moury, Igor B Títoff, Kevin M Kelly
There are 2 major categories of patients with seizures and chronic kidney disease (CKD): patients who develop acute symptomatic seizures in the setting of CKD and patients with epilepsy who at some point develop CKD. The incidence of uremic seizures with kidney failure is ∼10%. These seizures are often nonconvulsive and may mimic uremic encephalopathy. Recognition and management of such situations may be challenging for treating physicians who are non-neurologists. Furthermore, practitioners caring for patients with seizures with or without an established diagnosis of epilepsy in the setting of CKD frequently encounter challenges in the selection, loading, titration, and maintenance of antiepileptic drugs (AEDs) due to potentially altered pharmacokinetics of the AEDs...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29784220/expressed-emotion-and-family-burden-in-relatives-of-patients-in-first-episode-psychosis
#7
Ana Carolina G Zanetti, Tais Milena Pantaleão de Souza, Larissa de Souza Tressoldi, João Mazzoncini de Azevedo-Marques, Gabriel Elias Corrêa-Oliveira, Amanda Heloisa Santana da Silva, Isabela Dos Santos Martin, Kelly Graziani Giacchero Vedana, Lucilene Cardoso, Sueli Aparecida Frari Galera, Edilaine Cristina da Silva Gherardi-Donato
No abstract text is available yet for this article.
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784216/physical-and-mechanical-restraint-in-psychiatric-units-perceptions-and-experiences-of-nursing-staff
#8
Kelly Graziani Giacchero Vedana, Danielle Maria da Silva, Carla Aparecida Arena Ventura, Bianca Cristina Ciccone Giacon, Ana Carolina Guidorizzi Zanetti, Adriana Inocenti Miasso, Tatiana Longo Borges
BACKGROUND: Physical restraint in psychiatric units is a common practice but extremely controversial and poorly evaluated by methodologically appropriate investigations. The cultural issues and professionals' perceptions and attitudes are substantial contributors to the frequency of restraint that tend to be elevated. Aim In this qualitative study, we aimed to understand the experiences and perceptions of nursing staff regarding physical restraint in psychiatric units. METHOD: Through theoretical sampling, 29 nurses from two Brazilian psychiatric units participated in the study...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784050/exploring-hiv-risks-testing-and-prevention-among-sub-saharan-african-community-members-in-australia
#9
Amy B Mullens, Jennifer Kelly, Joseph Debattista, Tania M Phillips, Zhihong Gu, Fungisai Siggins
BACKGROUND: Significant health disparities persist regarding new and late Human Immunodeficiency Virus (HIV) diagnoses among sub-Saharan African (SSA) communities in Australia. Personal/cultural beliefs and practices influence HIV (risk, prevention, testing) within Australia and during visits to home countries. METHOD: A community forum was conducted involving 23 male and female adult African community workers, members and leaders, and health workers; facilitated by cultural workers and an experienced clinician/researcher...
May 21, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29783865/flow-cytometry-based-epitope-binning-using-competitive-binding-profiles-for-the-characterization-of-monoclonal-antibodies-against-cellular-and-soluble-protein-targets
#10
Brian M Chan, Anita Badh, Kelly A Berry, Stephanie A Grauer, Chadwick T King
A key step in the therapeutic antibody drug discovery process is early identification of diverse candidate molecules. Information comparing antibody binding epitopes can be used to classify antibodies within a large panel, guiding rational lead molecule selection. We describe a novel epitope binning method utilizing high-throughput flow cytometry (HTFC) that leverages cellular barcoding or spectrally distinct beads to multiplex samples to characterize antibodies raised against cell membrane receptor or soluble protein targets...
May 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29783680/-copaifera-of-the-neotropics-a-review-of-the-phytochemistry-and-pharmacology
#11
REVIEW
Rafaela da Trindade, Joyce Kelly da Silva, William N Setzer
The oleoresin of Copaifera trees has been widely used as a traditional medicine in Neotropical regions for thousands of years and remains a popular treatment for a variety of ailments. The copaiba resins are generally composed of a volatile oil made up largely of sesquiterpene hydrocarbons, such as β-caryophyllene, α-copaene, β-elemene, α-humulene, and germacrene D. In addition, the oleoresin is also made up of several biologically active diterpene acids, including copalic acid, kaurenoic acid, alepterolic acid, and polyalthic acid...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29783200/blood-lead-and-cadmium-levels-in-preschool-children-and-associated-risk-factors-in-s%C3%A3-o-paulo-brazil
#12
Kelly Polido Kaneshiro Olympio, Júlia Prestes da Rocha Silva, Agnes Soares da Silva, Vanessa Cristina de Oliveira Souza, Marília Afonso Rabelo Buzalaf, Fernando Barbosa, Maria Regina Alves Cardoso
In Brazil, there are scarce data on lead (Pb) and cadmium (Cd) contamination, especially for more vulnerable populations such as preschool children. In this paper, we answer two questions: (1) What are the exposure levels of lead and cadmium in preschool children, in Sao Paulo, Brazil? and (2) What are the risk factors associated with this exposure? This cross-sectional study included 50 day care centers (DCCs), totaling 2463 children aged 1-4 years. Venous blood samples were analyzed by ICP-MS. Questionnaires were administered to the parents...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29782865/session-3-discussion-the-microstructure-of-eating
#13
Cordelia Running, Bryony James, James Hollis, Kelly Higgins
The Microstructure of Eating.
May 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29782846/abnormal-small-intestinal-epithelial-microvilli-in-patients-with-crohn-s-disease
#14
Kelli L VanDussen, Aleksandar Stojmirović, Katherine Li, Ta-Chiang Liu, Patrick K Kimes, Brian D Muegge, Katherine F Simpson, Matthew A Ciorba, Jacqueline G Perrigoue, Joshua R Friedman, Jennifer E Towne, Richard D Head, Thaddeus S Stappenbeck
BACKGROUND & AIMS: Crohn's disease (CD) presents as chronic and often progressive intestinal inflammation, but the contributing pathogenic mechanisms are unclear. We aimed to identify alterations in intestinal cells that could contribute to the chronic and progressive course of CD. METHODS: We took an unbiased, system-wide approach, performing sequence analysis of RNA extracted from formalin-fixed, paraffin-embedded ileal tissue sections from patients with CD (n=36) and without CD (controls, n=32)...
May 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29782438/a-qualitative-study-on-midwives-perceptions-of-physiologic-birth-in-singapore
#15
Cassandra Yuit Wah Wong, Shefaly Shorey, Kelly Liew, Hong-Gu He, Serena S L Koh
Midwives are advocates for parturients, and their actions and attitudes can influence a woman's experience during childbirth. Hence, it is valuable to examine midwives' perceptions of physiologic birth in an obstetric-led environment. A descriptive, qualitative study design was utilized. Semistructured face-to-face interviews were conducted with 10 registered midwives from the birthing suite of a public hospital in Singapore. Data were analyzed using thematic analysis. Three major themes were (1) perceptions of physiologic birth, (2) perceived facilitators of physiologic birth, and (3) perceived barriers to physiologic birth...
May 17, 2018: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29782374/how-systematic-compliance-practices-can-address-regulatory-and-risk-issues-in-healthcare
#16
Julie Hamilton, Kelly J Sauders
No abstract text is available yet for this article.
2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29782017/measuring-trans-plasma-membrane-electron-transport-by-c2c12-myotubes
#17
Shannon C Kelly, Amanda M Eccardt, Jonathan S Fisher
Trans-plasma membrane electron transport (tPMET) plays a role in protection of cells from intracellular reductive stress as well as protection from damage by extracellular oxidants. This process of transporting electrons from intracellular reductants to extracellular oxidants is not well defined. Here we present spectrophotometric assays by C2C12 myotubes to monitor tPMET utilizing the extracellular electron acceptors: water-soluble tetrazolium salt-1 (WST-1) and 2,6-dichlorophenolindophenol (DPIP or DCIP)...
May 4, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781988/automated-slide-scanning-and-segmentation-in-fluorescently-labeled-tissues-using-a-widefield-high-content-analysis-system
#18
Candice C Poon, Vincent Ebacher, Katherine Liu, Voon Wee Yong, John James Patrick Kelly
Automated slide scanning and segmentation of fluorescently-labeled tissues is the most efficient way to analyze whole slides or large tissue sections. Unfortunately, many researchers spend large amounts of time and resources developing and optimizing workflows that are only relevant to their own experiments. In this article, we describe a protocol that can be used by those with access to a widefield high-content analysis system (WHCAS) to image any slide-mounted tissue, with options for customization within pre-built modules found in the associated software...
May 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781924/changes-in-psychiatric-and-medical-conditions-and-health-care-utilization-following-a-diagnosis-of-sexual-assault-a-retrospective-cohort-study
#19
Kelly C Young-Wolff, Varada Sarovar, Daniella Klebaner, Felicia Chi, Brigid McCaw
INTRODUCTION: Sexual assault (SA) is alarmingly common and is associated with higher prevalence of psychiatric and medical conditions. However, many prior studies are limited to cross-sectional designs. Health care systems with electronic health records provide unique longitudinal data to examine whether SA is associated with changes in health and health care utilization. METHODS: The sample included 1350 Kaiser Permanente Northern California adult female patients with a SA diagnosis from 2009 to 2015 and 4050 adult female patients without a SA diagnosis, matched on age, medical facility, and continuous enrollment during the study period...
May 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29781889/using-a-clinician-administered-interview-to-examine-the-overlap-in-posttraumatic-stress-disorder-criteria-d-and-e
#20
C Laurel Franklin, Amanda M Raines, Jessica L Walton, Jessica L Chambliss, Kelly P Maieritsch
Although the diagnosis of posttraumatic stress disorder (PTSD) is often criticized for including symptoms that overlap with one another, only one study has explored the impact of symptom reporting. Using a clinician-rated interview for PTSD (N = 558), the current study examined overlap between PTSD criteria D1, D2, and D3 ("target D symptoms") and criterion E symptoms of similar content (i.e., E1 and E3). Furthermore, their impact on meeting criterion and disorder cutoffs was examined. Results revealed that target symptoms were endorsed in conjunction more than half the time...
May 17, 2018: Journal of Nervous and Mental Disease
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