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Zhao-Yang Lu, Rui-Lin Li, Hong-Sheng Zhou, Jing-Juan Huang, Zhi-Xiao Su, Jia Qi, Lan Zhang, Yue Li, Yi-Qin Shi, Chang-Ning Hao, Jun-Li Duan
Therapeutic ultrasound (TUS) has been demonstrated to improve endothelial nitric oxide synthase (eNOS) activity, which played a crucial role in the regulation of angiogenesis. Diabetes Mellitus (DM) impairs eNOS activity. We tested the hypothesis that DM may retard unilateral hindlimb ischemia-induced angiogenesis by inhibiting eNOS in high-fat diet (HFD)/streptozocin (STZ) induced diabetic mice, and that TUS may reverse DM-related impairment of angiogenesis. C57BL/6 mice were allocated to four groups: (A) mice were fed standard diet (control); (B) mice were fed standard diet and treated with TUS (control+TUS); (C) type-2 DM mice were induced by HFD/STZ (diabetic); and (D) type-2 DM mice and treated with TUS (dabetic+TUS)...
2016: American Journal of Translational Research
Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Sumra Nazir, Hongjie Wang, Shrey Kohli, Satish Ranjan, Peter R Mertens, Peter P Nawroth, Berend Isermann
While a plethora of studies support a therapeutic benefit of Nrf2 activation and ROS inhibition in diabetic nephropathy (dNP), the Nrf2 activator bardoxolone failed in clinical studies in type 2 diabetic patients due to cardiovascular side effects. Hence, alternative approaches to target Nrf2 are required. Intriguingly, the tetracycline antibiotic minocycline, which has been in clinical use for decades, has been shown to convey anti-inflammatory effects in diabetic patients and nephroprotection in rodent models of dNP...
October 10, 2016: Scientific Reports
Juliane Wolter, Lorenz Schild, Fabian Bock, Andrea Hellwig, Ihsan Gadi, Moh D Mohanad Al-Dabet, Satish Ranjan, Raik Rönicke, Peter P Nawroth, Karl-Uwe Petersen, Christian Mawrin, Khurrum Shahzad, Berend Isermann
BACKGROUND: Studies with human samples and in rodents established a function of coagulation proteases in neuro-inflammatory demyelinating diseases, e.g. in multiple sclerosis (MS) and experimental autoimmune encephalitis (EAE). Surprisingly, approaches to increase aPC plasma levels as well as antibody mediated inhibition of PC/aPC ameliorated EAE in mice. Hence, the role of aPC generation in demyelinating diseases and potential mechanisms involved remain controversial. Furthermore, it is not known whether loss of aPC has pathological consequences at baseline, e...
September 3, 2016: Journal of Thrombosis and Haemostasis: JTH
Shrey Kohli, Satish Ranjan, Juliane Hoffmann, Muhammed Kashif, Evelyn A Daniel, Moh'd Mohanad Al-Dabet, Fabian Bock, Sumra Nazir, Hanna Huebner, Peter R Mertens, Klaus-Dieter Fischer, Ana C Zenclussen, Stefan Offermanns, Anat Aharon, Benjamin Brenner, Khurrum Shahzad, Matthias Ruebner, Berend Isermann
Preeclampsia (PE) is a placenta-induced inflammatory disease associated with maternal and fetal morbidity and mortality. The mechanisms underlying PE remain enigmatic and delivery of the placenta is the only known remedy. PE is associated with coagulation and platelet-activation and increased extracellular vesicles (EV) formation. However, thrombotic occlusion of the placental vascular bed is rarely observed and the mechanistic relevance of EV and platelet-activation remains unknown. Here we show that EV induce a thrombo-inflammatory response specifically in the placenta...
September 2, 2016: Blood
Michelle Woods, Giuliana Murfet
No abstract text is available yet for this article.
April 2016: Australian Nursing & Midwifery Journal
Meidong Yao, Yanhui Wu, Qingxiao Fang, Lulu Sun, Tingting Li, Hong Qiao
AIMS/INTRODUCTION: To investigate the association between two SNPs (rs3774261 and rs822393)in the ADIPOQ gene and type 2 diabetes mellitus in Han Chinese from northeast China. MATERIALS AND METHODS: This study comprised 993 type 2 diabetes mellitus subjects and 966 unrelated controls from northeastern China. Two SNPs were sequenced using SNPscan.The distribution of genotype frequencies of the two SNPs in ADIPOQ between cases and controls,and in subgroups stratified based on body mass index (BMI),were compared using logistic regression analysis...
May 1, 2016: Journal of Diabetes Investigation
Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Shrey Kohli, Sumra Nazir, Sanchita Ghosh, Satish Ranjan, Hongjie Wang, Thati Madhusudhan, Peter P Nawroth, Berend Isermann
Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and CIX (inhibiting caspase-3, -6, -7, -8, and -10). Notably, despite reduction in glomerular cell death and caspase-3 activity by both inhibitors, only M-920 ameliorated dNP. Nephroprotection by M-920 was associated with reduced renal caspase-1 and inflammasome activity...
August 2016: Journal of the American Society of Nephrology: JASN
Allison Tsai
No abstract text is available yet for this article.
September 2015: Diabetes Forecast
Dabet Rynga, Malini Shariff, Monorama Deb
BACKGROUND: Acinetobacter has gained importance as a multi-drug resistant and hence a difficult to treat pathogen. This study was done to characterize our isolates with respect to drug resistance and presence of beta-lactamases which is a major mechanism of resistance and to type using RAPD and MLST so that comparison of our clones can be made with the existing international clones. METHODS: 100 isolates recovered from clinical samples from two hospitals in Delhi were tested for their susceptibility against major groups of antimicrobials...
2015: Annals of Clinical Microbiology and Antimicrobials
M M Iversen, G Nefs, G S Tell, B Espehaug, K Midthjell, M Graue, F Pouwer
BACKGROUND: Depression and anxiety have been found to be predictors of poor health outcomes in diabetes, but mechanisms are still unclear. AIMS: To examine whether symptoms of anxiety and depression were associated with timing of initiating insulin therapy. METHODS: A cohort study of insulin-naive particpants with type 2 dabetes completed the Hospital Anxiey and Depression Scale, HADS-A (n = 731) and/or the HADS-D (n = 768) in the communy-based Nord-Trøndelag Health Study (1995-1997)...
October 2015: Journal of Psychosomatic Research
Wei Dong, Hongjie Wang, Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Satish Ranjan, Juliane Wolter, Shrey Kohli, Juliane Hoffmann, Vishnu Mukund Dhople, Cheng Zhu, Jonathan A Lindquist, Charles T Esmon, Elisabeth Gröne, Herman-Josef Gröne, Thati Madhusudhan, Peter R Mertens, Dirk Schlüter, Berend Isermann
Ischemia-reperfusion injury (IRI) is the leading cause of ARF. A pathophysiologic role of the coagulation system in renal IRI has been established, but the functional relevance of thrombomodulin (TM)-dependent activated protein C (aPC) generation and the intracellular targets of aPC remain undefined. Here, we investigated the role of TM-dependent aPC generation and therapeutic aPC application in a murine renal IRI model and in an in vitro hypoxia and reoxygenation (HR) model using proximal tubular cells. In renal IRI, endogenous aPC levels were reduced...
November 2015: Journal of the American Society of Nephrology: JASN
S F Haghighi, Z Salehi, M R Sabouri, N Abbasi
Dabetic retinopatny Is the most common microvascular complication of diabetes and a leading cause of blindness in industrialized countries. Oxidative stress plays an important role in the development of microangiopathic complications in diabetes. Manganese superoxide dismutase (MnSOD) is a key mitochondrial antioxidant enzyme in the cellular defense against agents that induce oxidative stress. The aim of the present study was to assess whether the MnSODA16V (C47T) polymorphism is associated with Diabetic retinopathy in northern Iran...
January 2015: Molekuliarnaia Biologiia
Khurrum Shahzad, Fabian Bock, Wei Dong, Hongjie Wang, Stefan Kopf, Shrey Kohli, Moh'd Mohanad Al-Dabet, Satish Ranjan, Juliane Wolter, Christian Wacker, Ronald Biemann, Stoyan Stoyanov, Klaus Reymann, Peter Söderkvist, Olaf Groß, Vedat Schwenger, Sascha Pahernik, Peter P Nawroth, Herman-Josef Gröne, Thati Madhusudhan, Berend Isermann
Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic nephropathy with inflammasome activation has recently been shown, but the pathophysiological relevance of this finding remains unknown. Within glomeruli, inflammasome activation was detected in endothelial cells and podocytes in diabetic humans and mice and in glucose-stressed glomerular endothelial cells and podocytes in vitro...
January 2015: Kidney International
Tim S Poulsen, Maiken L M Espersen, Vibeke Kofoed, Tanja Dabetic, Estrid Høgdall, Eva Balslev
The purpose was to evaluate and compare 5 different HER2 genetic assays with different characteristics that could affect the performance to analyze the human epidermal growth factor 2 (HER2) gene copy number under low and high throughput conditions. The study included 108 tissue samples from breast cancer patients with HER2 immunohistochemistry (IHC) results scored as 0/1+, 2+, and 3+. HER2 genetic status was analysed using chromogenic in situ hybridization (CISH) and fluorescence in situ hybridization (FISH)...
2013: International Journal of Breast Cancer
G Mahendran, G Thamotharan, S Sengottuvelu, V Narmatha Bai
ETHNOPHARMACOLOGICALS RELEVANCE: Swertia corymbosa locally called as Shirattakuchi have a long history of use in Ayurveda herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. AIM OF THE STUDY: The present study aimed to investigate the effect of the methanolic extract of Swertia corymbosa (SC) in diabetic and to analyze its chemical composition by HPLC-ESI/MS that may correlate with their pharmacological activities...
February 12, 2014: Journal of Ethnopharmacology
Erika B Rangel
INTRODUCTION: Pancreas-kidney transplant is an effective treatment for patients with insulin-dependent dabetes and chronic renal failure. Reduction in technical failure loss and early acute rejection rates contributed to prolong pancreas graft survival. However, drug toxicity affects negatively both short- and long-term follow-ups. AREAS COVERED: This article reviews the existing literature and knowledge of the immunosuppressive drugs that are frequently used in pancreas transplant, including calcineurin inhibitors, sirolimus, corticosteroids, and mycophenolate...
December 2012: Expert Opinion on Drug Metabolism & Toxicology
Ch Amrouche, H Jamoussi Kamoun, N Trabelsi, S Blouza Chabchoub
BACKGROUND: LADA or type 1.5 diabetes is a slowly progressive form of autoimmune diabetes of adults. The aim of this study is to evaluate the frequency of autoimmmune markers and to identify patients with LADA among diabetics diagnosed initially as having type 2 diabetes. METHODS: Our study concerned 100 diabetics, aged between 31 and 77 years (age at onset > 30 years), with short term diabetes (duration < 6 years) and who required insulin therapy after 6 months from diagnosis of diabetes...
April 2008: La Tunisie Médicale
Srdan Popović, Dorde Nale, Marija Dabetić, Dragana Matanović, Vesna Dimitrijević-Srecković, Gordana Milić, Drasko Gostiljac, Svetlana Vujović, Nebojsa Antonijević, Tanja Nisić, Predrag Dordević
BACKGROUND/AIM: [corrected] During the first 10 years over 50% of diabetes patients develop erectile dysfunction (ED). It is more severe and resistant to therapy than in male patients with normal glucoregulation. The purpose of this pilot study was to estimate the tadalafil (Cialis) efficacy and safety in male patients with diabetes mellitus (DM), together with moderate to severe ED. METHODS: The study included 30 male patients with diagnozed type 1 or type 2 DM together with ED...
June 2007: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Ulla Helt Laursen, Kaarina Pihakaski-Maunsbach, Tae-Hwan Kwon, Erik Østergaard Jensen, Søren Nielsen, Arvid B Maunsbach
BACKGROUND/AIM: In a rat model, lithium treatment is associated with polyuria and severe downregulation of aquaporin-2 (AQP2) protein in the inner medulla (IM) or in the whole kidney. However, it is not known (1) to what extent this downregulation occurs at the mRNA level; (2) whether the main sodium transporter of the nephron, Na,K-ATPase, is regulated in parallel at the mRNA level, and (3) whether lithium treatment induces zonal or segmental differences in AQP2 and Na,K-ATPase mRNA levels...
2004: Nephron. Experimental Nephrology
L de Mingo, L Alonso Jimenez, H el Dabete, M J Cortes, R López de Miguel
The acute abdomen in childhood is in most cases caused by an acute appendicitis and rarely it is secondary to other diseases. It is for that reason, that we present two cases extremely rare of acute abdomen: the first one was an abdominal Actinomycosis secondary to acute appendicitis that looked like a tumor and the second that was an acute omentitis due to pinworms.
January 1993: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
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