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ceftriaxone group A

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https://www.readbyqxmd.com/read/28499284/emergence-and-spread-of-neisseria-gonorrhoeae-isolates-with-decreased-susceptibility-to-extended-spectrum-cephalosporins-in-argentina-2009-to-2013
#1
Ricardo Gianecini, Maria de Las Mercedes Romero, Claudia Oviedo, Martin Vacchino, Patricia Galarza
BACKGROUND: The emergence of Neisseria gonorrhoeae strains with decreased susceptibility to cephalosporins represents a major concern globally. The aim of this study was to examine the phenotypic and molecular characteristics of N. gonorrhoeae isolates with decreased susceptibility to ceftriaxone and cefixime in Argentina. METHODS: A total of 1987 isolates were collected during 2009 and 2013. The susceptibility to penicillin G, tetracycline, ciprofloxacin, cefixime, ceftriaxone, and azithromycin was determined using the agar dilution method...
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28480269/globicatella-sanguinis-osteomyelitis-and-bacteremia-review-of-an-emerging-human-pathogen-with-an-expanding-spectrum-of-disease
#2
Andy O Miller, Seanne P Buckwalter, Michael W Henry, Fann Wu, Katherine F Maloney, Bisrat K Abraham, Barry J Hartman, Barry D Brause, Susan Whittier, Thomas J Walsh, Audrey N Schuetz
BACKGROUND: Globicatella sanguinis is an uncommon pathogen that may be misdiagnosed as viridans group streptococci. We review the literature of Globicatella and report 2 clinical cases in which catalase-negative Gram-positive cocci resembling viridans group streptococci with elevated minimum inhibitory concentrations (MICs) to ceftriaxone were inconsistently identified phenotypically, with further molecular characterization and ultimate identification of G sanguinis. METHODS: Two clinical strains (from 2 obese women; 1 with a prosthetic hip infection and the other with bacteremia) were analyzed with standard identification methods, followed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry, 16S recombinant ribonucleic acid (rRNA), and sodA polymerase chain reaction (PCR)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28475731/evaluation-of-daptomycin-combinations-with-cephalosporins-or-gentamicin-against-streptococcus-mitis-group-strains-in-an-in-vitro-model-of-simulated-endocardial-vegetations-sevs
#3
Juwon Yim, Jordan R Smith, Nivedita B Singh, Seth Rice, Kyle Stamper, Cristina Garcia de la Maria, Arnold S Bayer, Nagendra N Mishra, José M Miró, Truc T Tran, Cesar A Arias, Paul Sullam, Michael J Rybak
Objectives: Among viridans group streptococcal infective endocarditis (IE), the Streptococcus mitis group is the most common aetiological organism. Treatment of IE caused by the S. mitis group is challenging due to the high frequency of β-lactam resistance, drug allergy and intolerability of mainstay antimicrobial agents such as vancomycin or gentamicin. Daptomycin has been suggested as an alternative therapeutic option in these scenarios based on its excellent susceptibility profile against S...
May 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28453565/risk-factors-and-outcome-of-shigella-encephalopathy-in-bangladeshi-children
#4
Farzana Afroze, Tahmeed Ahmed, Monira Sarmin, Abu Smsb Shahid, K M Shahunja, Lubaba Shahrin, Mohammod Jobayer Chisti
BACKGROUND: Although, Shigella encephalopathy, a serious extra-intestinal complication of shigellosis, significantly increases the risks of death, data are very limited on predicting factors particularly related to electrolyte profiles in children below five years of age with Shigella encephalopathy. Our objective was to determine the clinical as well as laboratory predicting factors and outcome of children with Shigella encephalopathy. METHODOLOGY/PRINCIPAL FINDINGS: In this unmatched case-control design, children aged 2-59 months having a positive stool culture for Shigella and who had their serum electrolytes been done from July 2012 to June 2015 were studied...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28430086/genotypic-relatedness-and-antimicrobial-resistance-of-salmonella-heidelberg-isolated-from-chickens-and-turkeys-in-the-midwestern-united-states
#5
Muhammad Nisar, Issmat I Kassem, Gireesh Rajashekara, Sagar M Goyal, Dale Lauer, Shauna Voss, Kakambi V Nagaraja
Salmonella is one of the most common causes of foodborne illnesses in humans in the United States, and domestic poultry is considered an important source of this pathogen. Salmonella enterica subsp. enterica serovar Heidelberg is the fourth most commonly reported Salmonella from retail meats and food animals in the United States. We assessed the genotypes and antimicrobial resistance phenotypes of Salmonella Heidelberg isolated from various chicken and turkey hatcheries and breeder farms in the Midwest. The genotypes of 33 S...
May 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28420242/high-prevalence-of-ndm-metallo-%C3%AE-lactamase-among-esbl-producing-escherichia-coli-%C3%A4-solates
#6
Yeliz Çetinkol, Cemal Sandalli, Mustafa Kerem Çalgin, Arzu Altunçekiç Yildirim, Esma Akyildiz, Esin Karaman, Ayşegül Çopur Çiçek
Resistance to β-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of β-lactamase genes and antibiotic resistance rates of 140 extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates obtained from urinary tract infection in Ordu Province, Turkey. Isolates were identified by classic methods and by automated system. ESBL production was confirmed by double disk synergy test and antimicrobial susceptibility was investigated by disk diffusion method...
April 19, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28409118/isolated-streptococcus-intermedius-pulmonary-nodules
#7
Stephen Catalya, Bushra Komal, Sunil Tulpule, Nazar Raoof, Shuvendu Sen
Streptococcus intermedius, a member of the Streptococcal anginosus group of alpha-hemolytic streptococci, remains a notable infectious agent causing necrotizing pneumonia and abscesses. We report a case of a young male with pulmonary nodules found to have Streptococcus intermedius and no other underlying hepatic or dental history who was treated with ceftriaxone and avoided surgical intervention. A review of the literature reveals cases that are typically treated with a combined surgical and medical approach...
2017: IDCases
https://www.readbyqxmd.com/read/28376315/safety-and-efficacy-of-a-novel-drug-elores-ceftriaxone-sulbactam-disodium-edetate-in-the-management-of-multi-drug-resistant-bacterial-infections-in-tertiary-care-centers-a-post-marketing-surveillance-study
#8
Manu Chaudhary, Mohd Amin Mir, Shiekh Gazalla Ayub
OBJECTIVE: In India, elores (CSE-1034: ceftriaxone+sulbactam+disodium edetate) was approved as a broad spectrum antibiotic in year 2011 and is used for management of ESBL/MBL infections in tertiary care centers. The objective of this study was to investigate the efficacy of this drug in patients with ESBL/MBL infections and identify the incidence of adverse events in real clinical settings. METHODS: This PMS study was conducted at 17 centers across India and included 2500 patients of all age groups suffering from various bacterial infections and treated with CSE-1034...
April 1, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28373186/in-vitro-activity-of-pexiganan-and-10-comparator-antimicrobials-against-234-isolates-including-93-pasteurella-spp-and-50-anaerobic-bacteria-recovered-from-animal-bite-wounds
#9
Ellie J C Goldstein, Diane M Citron, Kerin L Tyrrell, Eliza S Leoncio
Animal bite wounds affect more than 5 million Americans resulting in 300,000 Emergency Department visits, 10,000 hospitalizations and untold number of physician office visits annually. Various forms of topical therapy are empirically self-employed by many patients prior to seeking medical attention. Pexiganan, a 22-amino acid synthetic cationic analogue of peptide magainin II, acts by selectively damaging bacterial cell membranes. We determined the MICs for pexiganan and other antimicrobial agents often used for treatment of bite wounds...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28348155/molecular-%C3%AE-lactamase-characterization-of-aerobic-gram-negative-pathogens-recovered-from-patients-enrolled-in-the-ceftazidime-avibactam-phase-3-trials-for-complicated-intra-abdominal-infections-efficacies-analyzed-against-susceptible-and-resistant-subsets
#10
Rodrigo E Mendes, Mariana Castanheira, Leah N Woosley, Gregory G Stone, Patricia A Bradford, Robert K Flamm
The correlation of clinical efficacy of ceftazidime-avibactam (plus metronidazole) and meropenem was evaluated in subjects infected with Gram-negative isolates having characterized β-lactam resistance mechanisms from the complicated intra-abdominal infection (cIAI) phase 3 clinical trials. Enterobacteriaceae displaying ceftriaxone and/or ceftazidime MIC values of ≥2 μg/ml and Pseudomonas aeruginosa with ceftazidime MIC values of ≥16 μg/ml were characterized for extended-spectrum β-lactamase (ESBL) content...
March 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320712/efficacy-of-telavancin-alone-and-in-combination-with-ampicillin-in-a-rat-model-of-enterococcus-faecalis-endocarditis
#11
Truc T Tran, Vincent H Tam, Barbara E Murray, Cesar A Arias, Kavindra V Singh
We first assessed telavancin (TLV) pharmacokinetics after a single subcutaneous dose of 35 mg/kg. The pharmacokinetic data were used to predict a TLV dose that simulates human exposure and the efficacy of TLV was then evaluated using TLV 21 mg/kg Q 12 h against Enterococcus faecalis OG1RF (TLV MIC of 0.06 μg/ml) in a rat endocarditis model with an indwelling catheter. Therapy was given for 3 days with TLV, daptomycin (DAP) or ampicillin (AMP) monotherapy and with combinations of TLV plus AMP, AMP plus gentamicin (GEN), and AMP plus ceftriaxone (CRO); rats were sacrificed 24 h after the last dose...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320396/occurrence-of-bla-dha-1-mediated-cephalosporin-resistance-in-escherichia-coli-and-their-transcriptional-response-against-cephalosporin-stress-a-report-from-india
#12
Birson Ingti, Deepjyoti Paul, Anand Prakash Maurya, Debajyoti Bora, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
BACKGROUND: Treatment alternatives for DHA-1 harboring strains are challenging as it confers resistance to broad spectrum cephalosporins and may further limit treatment option when expressed at higher levels. Therefore, this study was designed to know the prevalence of DHA genes and analyse the transcription level of DHA-1 against different β-lactam stress. METHODS: Screening of AmpC β-lactamase phenotypically by modified three dimensional extract method followed by Antimicrobial Susceptibility and MIC determination...
March 21, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28303826/prevalence-of-pneumococcal-serotypes-in-adults-%C3%A2-50-years-of-age
#13
Chand Wattal, Neeraj Goel, S P Byotra
CONTEXT: Currently, majority of studies on antibiotic resistance and serotype prevalence in Streptococcus pneumoniae are in paediatric population and there is limited epidemiologic data pertaining to elderly Indian population. AIMS: This study was undertaken to assess antibiotic resistance pattern and the coverage of the polysaccharide vaccine 23 (PPV23) in the elderly population. SETTINGS AND DESIGN: This was a prospective 2-year pneumococcal surveillance study in patients with community-acquired pneumococcal infections of ≥50 years' age group on fifty isolates of S...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28263245/the-treatment-of-possible-severe-infection-in-infants-an-open-randomized-safety-trial-of-parenteral-benzylpenicillin-and-gentamicin-versus-ceftriaxone-in-infants-60-days-of-age-in-malawi
#14
Elizabeth M Molyneux, Queen Dube, Francis Banda, Msandeni Chiume, Isaac Singini, Macpherson Mallewa, Edward C Schwalbe, Robert S Heyderman
BACKGROUND: The World Health Organization recommends benzylpenicillin and gentamicin as antimicrobial treatment of infants with sepsis in low income settings (LICs), and ceftriaxone or cefotaxime as an alternative. In a meta-analysis from 13 LICs, Staphylococcus aureus, Klebsiella spp. and E.coli accounted for 55% of infants with sepsis. In a review of bacterial meningitis, resistance to third generation cephalosporins was >50% of all isolates, and 44% of Gram-negative isolates were gentamicin resistant...
February 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28251670/retrospective-audit-of-antimicrobial-prescribing-practices-for-acute-exacerbations-of-chronic-obstructive-pulmonary-diseases-in-a-large-regional-hospital
#15
D J Brownridge, S T R Zaidi
WHAT IS KNOWN AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality, and frequent exacerbations are associated with an increased risk of death, deterioration in lung function and reduced quality of life. Current Australian guidelines developed by the Lung Foundation of Australia (the COPD-X Plan) recommends the use of a short course of corticosteroids and oral antibiotics (amoxycillin or doxycycline) as part of the treatment of an AECOPD; however, it was noted that clinical practice at the study hospital had deviated from these guidelines...
June 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28245091/syn-004-ribaxamase-an-oral-beta-lactamase-mitigates-antibiotic-mediated-dysbiosis-in-a-porcine-gut-microbiome-model
#16
Sheila Connelly, J Andrew Bristol, Steven Hubert, Poorani Subramanian, Nur A Hasan, Rita R Colwell, Michael Kaleko
AIM: To evaluate an antibiotic-inactivation strategy to protect the gut microbiome from antibiotic-mediated damage. METHODS AND RESULTS: SYN-004 (ribaxamase) is an orally-delivered beta-lactamase intended to degrade penicillins and cephalosporins within the gastrointestinal tract to protect the microbiome. Pigs (20 kg, n=10) were treated with ceftriaxone (IV, 50 mg kg(-1) , SID) for 7 days and a cohort (n=5) received ribaxamase (PO, 75 mg, QID) for 9 days beginning the day before antibiotic administration...
February 28, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28208889/management-of-pneumonia-and-blood-stream-infections-with-new-antibiotic-adjuvant-entity-ceftriaxone-sulbactam-disodium-edetate-a-novel-way-to-spare-carbapenems
#17
Mohammad Shameem, Mohammad Amin Mir
INTRODUCTION: Nosocomial infections have been considered as a major health problem causing incremental morbidity, mortality and costs of therapy. AIM: This retrospective study was initiated with aim to analyse the comparative efficacy of a novel Antibiotic Adjuvant Entity (AAE), a combination of ceftriaxone + sulbactam + disodium edetate and meropenem in combination with colistin, for the management of Multi Drug Resistant (MDR) nosocomial Gram-negative bacterial infections...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28191374/klebsiella-pneumoniae-liver-abscess-a-case-report-and-review-of-literature
#18
Faisal Kamal, George Williams, Hina Akbar, Muhammad Ali Khan, Dipen Kadaria
Klebsiella pneumoniae (K.pneumoniae) is a known cause of pyogenic liver abscess (PLA) in the absence of hepatobiliary disease. In settings of hepatic infection, it has also been known to cause disseminated infections including meningitis and endopthalmitis. Several groups of patients are particularly susceptible to infection, including patients with diabetes mellitus, those from Southeast Asia and those with the preexisting hepatobiliary disease. We present a case of K.pneumoniae PLA with bacteremia. A 39-year-old Vietnamese male with no previous medical history who presented with complaints of abdominal pain, nausea, vomiting, diarrhea and fever...
January 10, 2017: Curēus
https://www.readbyqxmd.com/read/28167960/addition-of-ceftriaxone-and-amikacin-to-a-ciprofloxacin-plus-metronidazole-regimen-for-preventing-infectious-complications-of-transrectal-ultrasound-guided-prostate-biopsy-a-randomized-controlled-trial
#19
Mohammad-Hossein Izadpanahi, Kia Nouri-Mahdavi, Seyed Mahmood Majidi, Mohammad-Hatef Khorrami, Farshid Alizadeh, Mehrdad Mohammadi-Sichani
Background. The objective of this study was to evaluate the efficacy of adding single doses of ceftriaxone and amikacin to a ciprofloxacin plus metronidazole regimen on the reduction of infectious complications following transrectal ultrasound-guided prostate biopsy (TRUS Bx). Materials and Methods. Four hundred and fifty patients who were candidates for TRUS Bx were divided into two groups of 225 each. The control group received ciprofloxacin 500 mg orally every 12 hours together with metronidazole 500 mg orally every 8 hours from the day prior to the procedure until the fifth postoperative day...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28137797/a-whole-genome-sequencing-approach-to-study-cefoxitin-resistant-salmonella-enterica-serovar-heidelberg-isolates-from-various-sources
#20
Romaine Edirmanasinghe, Rita Finley, E Jane Parmley, Brent P Avery, Carolee Carson, Sadjia Bekal, George Golding, Michael R Mulvey
This study characterized cefoxitin-resistant and -susceptible Salmonella enterica serovar Heidelberg strains from humans, abattoir poultry, and retail poultry to assess the molecular relationships of isolates from these sources in Québec in 2012. Isolates were collected as part of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). All isolates were subjected to antimicrobial susceptibility testing, PCR for CMY-2, pulsed-field gel electrophoresis (PFGE), and whole-genome sequencing (WGS)...
April 2017: Antimicrobial Agents and Chemotherapy
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