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ceftriaxone group A

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https://www.readbyqxmd.com/read/28919603/current-trends-of-using-antimicrobials-at-obstetrics-and-gynaecology-department-in-a-tertiary-care-hospital
#1
M M Islam, S K Saha, S Saha, U A Wahid, R R Gomes, K S Ahmed, A N Naushad, S E Suchi, C Saha, D Mondal
This cross-sectional descriptive study was done to analyse the current trends of using antimicrobials in various surgical procedures at Obstetrics and Gynaecology department in Mymensingh Medical College Hospital, Mymensingh from July 2014 to June 2015. Among 300 postoperative obstetrics and gynaecological surgery cases, samples were selected as non-random purposive selection method where pattern of using antimicrobials were analysed by SPSS method 20.1 versions. The incidence of antimicrobial resistance is on continued rise with a threat to return to the pre-antibiotic era...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28906422/increased-risk-of-acute-kidney-injury-in-critically-ill-children-treated-with-vancomycin-and-piperacillin-tazobactam
#2
Maya R Holsen, Calvin J Meaney, Amanda B Hassinger, Nicholas M Fusco
OBJECTIVES: Compare the rates of acute kidney injury in critically ill children treated with vancomycin and piperacillin-tazobactam versus vancomycin and ceftriaxone. DESIGN: Retrospective cohort study. SETTING: A large tertiary care children's hospital in an urban setting. PATIENTS: Children greater than or equal to 2 months old admitted to the PICU who received greater than or equal to 48 consecutive hours of vancomycin and piperacillin-tazobactam or vancomycin and ceftriaxone...
September 12, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28899468/-pathogen-distribution-and-bacterial-resistance-in-children-with-severe-community-acquired-pneumonia
#3
Yun-Yun Lu, Rong Luo, Zhou Fu
OBJECTIVE: To investigate the distribution of pathogens and bacterial resistance in children with severe community-acquired pneumonia (CAP). METHODS: A total of 522 children with severe CAP who were hospitalized in 2016 were enrolled as study subjects. According to their age, they were divided into infant group (402 infants aged 28 days to 1 year), young children group (73 children aged 1 to 3 years), preschool children group (35 children aged 3 to 6 years), and school-aged children group (12 children aged ≥6 years)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28844213/effects-of-rhubarb-rheum-ribes-l-syrup-on-dysenteric-diarrhea-in-children-a-randomized-double-blind-placebo-controlled-trial
#4
Ali Khiveh, Mohammad Hashem Hashempur, Mehrdad Shakiba, Mohammad Hassan Lotfi, Afsaneh Shakeri, SeidKazem Kazemeini, Zohre Mousavi, Marzie Jabbari, Mohammad Kamalinejad, Majid Emtiazy
BACKGROUND: Rheum ribes L. is a plant native to China, Iran, Turkey, India, and a few other countries. Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional medicine. An increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children, and underlines a need for safe, efficient and valid options. OBJECTIVE: The purpose of this study is to evaluate the efficacy of R...
September 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28831325/prescription-of-antibiotics-to-treat-gonorrhoea-in-general-practice-in-flanders-2009-2013-a-registry-based-retrospective-cohort-study
#5
Christoph Schweikardt, Geert Goderis, Steven Elli, Yves Coppieters
BACKGROUND: General practitioners (GPs) as a group have been identified as playing an important role in gonorrhoea management in Flanders. Belgian guidelines recommended ceftriaxone or alternatively spectinomycin from 2008 onwards and azithromycin combination therapy since 2012. OBJECTIVES: This study investigates to which extent contemporary gonorrhoea treatment guidelines were followed. METHODS: A retrospective cohort study (2009-2013) of antibiotic prescriptions for gonorrhoea cases registered in the Flemish Intego general practice database was carried out...
2017: Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28827252/safety-of-ceftriaxone-in-paediatrics-a-systematic-review-protocol
#6
Linan Zeng, Imti Choonara, Lingli Zhang, Song Xue, Zhe Chen, Miaomiao He
INTRODUCTION: Ceftriaxone is widely used in children in the treatment of sepsis. However, concerns have been raised about the safety of ceftriaxone, especially in young children. The aim of this review is to systematically evaluate the safety of ceftriaxone in children of all age groups. METHODS AND ANALYSIS: MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, International Pharmaceutical Abstracts and adverse drug reaction (ADR) monitoring systems will be systematically searched for randomised controlled trials (RCTs), cohort studies, case-control studies, cross-sectional studies, case series and case reports evaluating the safety of ceftriaxone in children...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28826758/%C3%AE-lactamase-inhibitor-clavulanic-acid-attenuates-ethanol-intake-and-increases-glial-glutamate-transporters-expression-in-alcohol-preferring-rats
#7
Alqassem Y Hakami, Youssef Sari
Studies from our laboratory showed that upregulation of glutamate transporter 1 (GLT-1) and cystine-glutamate exchanger (xCT) expression with ceftriaxone, β-lactam antibiotic, in the brain was associated with attenuation of ethanol consumption. In this study, we tested clavulanic acid, which is another β-lactam compound with negligible antimicrobial activity, on ethanol consumption and expression of GLT-1, xCT and glutamate aspartate transporter (GLAST) in male alcohol-preferring (P) rats. Clavulanic acid has the central β-lactam pharmacophore that is critical for the upregulation of GLT-1 and xCT expression...
September 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28818575/beta-lactam-resistance-among-haemophilus-influenzae-isolates-in-poland
#8
Marlena Kiedrowska, Alicja Kuch, Dorota Żabicka, Izabela Waśko, Patrycja Ronkiewicz, Katarzyna Wasiak, Katarzyna Bojarska, Waleria Hryniewicz, Anna Skoczyńska
OBJECTIVES: Haemophilus influenzae is a human-specific Gram-negative coccobacillus responsible for a significant number of respiratory tract infections and severe invasive infections such as meningitis and sepsis. The purpose of the study was to characterize the mechanisms of β-lactam resistance among Polish H. influenzae isolates and to evaluate the methods applied. METHODS: The study was conducted on 117 Polish H. influenzae isolates collected in 2012. Minimal inhibitory concentrations (MICs) were assessed by the broth microdilution method...
August 14, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28813477/colonization-prevalence-and-antibiotic-susceptibility-of-group-b-streptococcus-in-pregnant-women-over-a-6-year-period-in-dongguan-china
#9
Wenjing Ji, Lihua Zhang, Zhusheng Guo, Shujin Xie, Weiqing Yang, Junjian Chen, Jiamin Wang, Zhiqin Cheng, Xin Wang, Xuehai Zhu, Jianwen Wang, Haiqing Wang, Juan Huang, Ning Liang, David J McIver
This study investigated the prevalence of recto-vaginal Group B Streptococcus (GBS) colonization, serotype distribution, and antimicrobial susceptibility patterns among pregnant women in Dongguan, China. Recto-vaginal swabs were collected from pregnant women at gestational age 35-37 weeks between January 1st 2009 and December 31st 2014. Isolates were serotyped by latex-agglutination and were tested against seven antimicrobials by disk diffusion. Of 7,726 pregnant women who completed GBS testing, 636 (8.2%) were GBS carriers...
2017: PloS One
https://www.readbyqxmd.com/read/28807914/amplification-of-antimicrobial-resistance-in-gut-flora-of-patients-treated-with-ceftriaxone
#10
J Meletiadis, A Turlej-Rogacka, A Lerner, A Adler, E Taconelli, J W Mouton
Although antibacterial therapy has an impact on human intestinal flora and emergence of resistant bacteria, its role on amplification of antimicrobial resistance and the quantitative exposure-effect relationship is not clear. An observational prospective study was conducted to determine whether and how ceftriaxone exposure is related to amplification of resistance in non- ICU patients.Serial stool samples from 122 ESBL(+) hospitalized patients were analyzed with quantitative real-time PCR to quantify the resistant gene blaCTX-M Drug exposure was calculated for each patient using a population pharmacokinetic model...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28804111/an-adult-case-of-group-a-streptococcus-meningitis-associated-with-steroid-responsive-meningoencephalitis
#11
Koji Shimozono, Yoshiko Hayashi, Tokuji Nishinaka, Sayaka Kobayashi
A previously healthy 80-year-old woman presented to our service in a comatose state. On examination the patient had fever and neck stiffness. Laboratory investigation showed polymorphonuclear pleocytosis in cerebro-spinal fluid (CSF). These findings prompted us to a diagnosis of bacterial or viral meningitis and combination therapy consisting of ceftriaxone, vancomycin and acyclovir was started immediately. Two days later, culture of blood yielded Streptococcus pyogenes (group A streptococcus; GAS). The antibiotic therapy was converted to intravenous ampicillin for 14 days...
August 11, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28735053/activity-of-dalbavancin-tested-against-gram-positive-clinical-isolates-causing-skin-and-skin-structure-infections-in-paediatric-patients-from-us-hospitals-2014-2015
#12
Michael A Pfaller, Rodrigo E Mendes, Helio S Sader, Mariana Castanheira, Robert K Flamm
OBJECTIVES: This study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin-structure infections (SSSIs) in children. METHODS: A total of 770 Staphylococcus aureus, 167 β-haemolytic streptococci (BHS), 42 coagulase-negative staphylococci (CoNS), 25 Enterococcus faecalis and 13 viridans group streptococci (VGS) were collected from children (<18years old) in the USA (2014-2015). RESULTS: Dalbavancin had MIC50/90 values of 0...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28713083/regional-features-of-the-microbial-landscape-of-urine-and-comparative-evaluation-of-antimicrobial-therapy-in-children-with-cystitis
#13
Tetyana O Kryuchko, Vira P Kharshman, Inna M Nesina, Nataliia V Kuzmenko, Jaroslava M Oleksiienko
INTRODUCTION: Growing resistance of pathogens to antibiotics, including cross-resistance to other antimicrobial classes that are used in the treatment of recurrent infections of the lower urinary system in children demands constant control of issues of regional antibiotic resistance. In the present days, in the empirical treatment of such patients physicians still choose medications with preserved activity in relation to E. coli. The aim of our study was to investigate the regional features of microbial landscape of urine in children with cystitis and study the efficacy of 7-day administration of Furamag medicinal drug for the treatment of recurrent episodes of this disease in children...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28702149/postoperative-antibiotic-therapy-after-appendectomy-in-patients-with-non-perforated-appendicitis
#14
Seyed-Mohammadreza Sadraei-Moosavi, Novin Nikhbakhsh, Ali-Asghar Darzi
BACKGROUND: Appendectomy intra-abdominal is the most frequently performed emergency surgery. This study was conducted to determine the role of postoperative antibiotics in reducing surgical site infections (SSIs) and abscess formation after open appendectomy. METHODS: In the Department of Surgery, Shahid Beheshti Hospital, Babol, Iran, from October 2013 to October 2014 one hundred and fifty two patients, who underwent appendectomy for nonperforated appendicitis (NPA) and fulfilled the selection criteria, were randomized into two groups...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28687200/ceftriaxone-reduces-alcohol-intake-in-outbred-rats-while-upregulating-xct-in-the-nucleus-accumbens-core
#15
Bethany A Stennett, Jan C Frankowski, Joanna Peris, Lori A Knackstedt
Alcohol addiction is a chronic disease characterized by an inability to regulate drinking. A critical brain region involved in alcohol consumption is the nucleus accumbens (NA). Glutamate transmission in this region regulates alcohol consumption and relapse to alcohol-seeking. Across multiple alcohol-administration rodent models, basal extracellular glutamate levels are increased in the NA during early withdrawal. Glutamate transporter 1 (GLT-1) and system xC-, containing the subunit xCT, regulate NA glutamate levels...
August 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28658325/comparison-of-efficacy-of-treatments-for-early-syphilis-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials-and-observational-studies
#16
REVIEW
Hong-Ye Liu, Yan Han, Xiang-Sheng Chen, Li Bai, Shu-Ping Guo, Li Li, Peng Wu, Yue-Ping Yin
BACKGROUND: Parenteral penicillin is the first-line regimen for treating syphilis, but unsuitable for some patients due to penicillin allergy and lacking health resources. Unfortunately, the efficacy of penicillin alternatives remains poorly understood. This study aimed to assess the efficacy of ceftriaxone and doxycycline/tetracycline in treating early syphilis relative to that of penicillin, and thereby to determine which antibiotic is a better replacement for penicillin. METHOD: By searching literature from PubMed, Cochrane Central Register of Controlled Trials, Embase, the Web of Science, and ClinicalTrials...
2017: PloS One
https://www.readbyqxmd.com/read/28656335/gentamicin-submucosal-lavage-during-peroral-endoscopic-myotomy-poem-a-retrospective-analysis
#17
Julia Bayer, Zuzana Vackova, Hana Svecova, Petr Stirand, Julius Spicak, Jan Martinek
BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) is an evolving therapeutic modality for achalasia. According to the original Inoue's technique, a submucosal lavage with gentamicin has been practiced due to the fear of infection. This single-tertiary center study was intended to assess the clinical significance of the topical antibiotic lavage during POEM. METHODS: A retrospective analysis of prospectively collected data was conducted. The outcomes of patients who received the gentamicin lavage (group A) during POEM were compared to those who did not (group B)...
June 27, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28654543/extended-versus-narrow-spectrum-antibiotics-in-the-management-of-uncomplicated-appendicitis-in-children-a-propensity-matched-comparative-effectiveness-study
#18
Danielle B Cameron, Patrice Melvin, Dionne A Graham, Charity C Glass, Stephanie K Serres, Matthew P Kronman, Jacqueline M Saito, Shawn J Rangel
OBJECTIVE: The aim of this study was to compare the effectiveness of extended versus narrow spectrum antibiotics in preventing surgical site infections (SSIs) and hospital revisits in children with uncomplicated appendicitis. SUMMARY OF BACKGROUND DATA: There is a paucity of high-quality evidence in the pediatric literature comparing the effectiveness of extended versus narrow-spectrum antibiotics in the prevention of SSIs associated with uncomplicated appendicitis...
June 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28631864/ceftriaxone-reduces-l-dopa-induced-dyskinesia-severity-in-6-hydroxydopamine-parkinson-s-disease-model
#19
Tanya Chotibut, Samantha Meadows, Ella A Kasanga, Tamara McInnis, Mark A Cantu, Christopher Bishop, Michael F Salvatore
BACKGROUND: Increased extracellular glutamate may contribute to l-dopa induced dyskinesia, a debilitating side effect faced by Parkinson's disease patients 5 to 10 years after l-dopa treatment. Therapeutic strategies targeting postsynaptic glutamate receptors to mitigate dyskinesia may have limited success because of significant side effects. Increasing glutamate uptake may be another approach to attenuate excess glutamatergic neurotransmission to mitigate dyskinesia severity or prolong the time prior to onset...
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28624317/modulatory-effects-of-ampicillin-sulbactam-on-glial-glutamate-transporters-and-metabotropic-glutamate-receptor-1-as-well-as-reinstatement-to-cocaine-seeking-behavior
#20
Alaa M Hammad, Fawaz Alasmari, Yusuf S Althobaiti, Youssef Sari
Glutamatergic system has an important role in cocaine-seeking behavior. Studies have reported that chronic exposure to cocaine induces downregulation of glutamate transporter-1 (GLT-1) and cystine/glutamate exchanger (xCT) in the central reward brain regions. Ceftriaxone, a β-lactam antibiotic, restored GLT-1 expression and consequently reduced cue-induced reinstatement of cocaine-seeking behavior. In this study, we investigated the reinstatement to cocaine (20mg/kg, i.p.) seeking behavior using a conditioned place preference (CPP) paradigm in male alcohol-preferring (P) rats...
August 14, 2017: Behavioural Brain Research
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