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https://www.readbyqxmd.com/read/29150472/are-food-and-drink-retailers-within-nhs-venues-adhering-to-nice-quality-standard-94-guidance-on-childhood-obesity-a-cross-sectional-study-of-two-large-secondary-care-nhs-hospitals-in-england
#1
Alice James, Laura Birch, Peter Fletcher, Sally Pearson, Catherine Boyce, Andy R Ness, Julian P Hamilton-Shield, Fiona E Lithander
OBJECTIVE: To assess whether the food and drink retail outlets in two major National Health Service (NHS) district general hospitals in England adhere to quality statements 1-3 of the UK National Institute for Health and Care Excellence (NICE) quality standard 94. DESIGN: Cross-sectional, descriptive study to assess the food and drink options available in vending machines, restaurants, cafes and shops in two secondary care hospitals. MAIN OUTCOME MEASURES: Adherence to quality statement 1 whereby the food and drink items available in the vending machines were classified as either healthy or less healthy using the Nutrient Profiling Model (NPM)...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149118/perceived-self-efficacy-a-concept-analysis-for-symptom-management-in-patients-with-cancer%C3%A2
#2
Lynn L White, Marlene Z Cohen, Ann M Berger, Kevin A Kupzyk, Barbara A Swore-Fletcher, Philip J Bierman
BACKGROUND: Perceived self-efficacy (PSE) for symptom management plays a key role in outcomes for patients with cancer, such as quality of life, functional status, symptom distress, and healthcare use. Definition of the concept is necessary for use in research and to guide the development of interventions to facilitate PSE for symptom management in patients with cancer.
. OBJECTIVES: This analysis will describe the concept of PSE for symptom management in patients with cancer...
December 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29141912/wh2-and-proline-rich-domains-of-wasp-family-proteins-collaborate-to-accelerate-actin-filament-elongation
#3
Peter Bieling, Scott D Hansen, Orkun Akin, Tai-De Li, Carl C Hayden, Daniel A Fletcher, R Dyche Mullins
WASP-family proteins are known to promote assembly of branched actin networks by stimulating the filament-nucleating activity of the Arp2/3 complex. Here, we show that WASP-family proteins also function as polymerases that accelerate elongation of uncapped actin filaments. When clustered on a surface, WASP-family proteins can drive branched actin networks to grow much faster than they could by direct incorporation of soluble monomers. This polymerase activity arises from the coordinated action of two regulatory sequences: (i) a WASP homology 2 (WH2) domain that binds actin, and (ii) a proline-rich sequence that binds profilin-actin complexes...
November 15, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29141508/anti-m%C3%A3-llerian-hormone-amh-may-stall-ovarian-cortex-function-through-modulation-of-hormone-receptors-other-than-the-amh-receptor
#4
Laura Detti, Nicole M Fletcher, Ghassan M Saed, Irene Peregrin-Alvarez, Rebecca A Uhlmann
OBJECTIVE: To test whether recombinant anti-Müllerian hormone (AMH) can inhibit ovarian cortex function by modulating the expression of other hormone receptors. MATERIALS AND METHODS: Pilot experimental study with ovarian cortex obtained from 5 patients. Immediately after explant, the ovarian cortex specimens were divided into 5 equal fragments. One fragment was flash-frozen (uncultured) and 4 were incubated for 48 hours at 37°C in a pH-adjusted gamete buffer medium with increasing AMH concentrations of 0, 5, 25, and 50 ng/mL...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29136181/dating-and-relationship-violence-among-16-19-year-olds-in-england-and-wales-a-cross-sectional-study-of-victimization
#5
Honor Young, Catherine Turney, James White, Chris Bonell, Ruth Lewis, Adam Fletcher
Background: Dating and relationship violence (DRV) is under-researched in the UK, especially among Further Education (FE) students. This study examines the association between DRV victimization and socio-demographic characteristics, sexual identity and dating and relationship behaviours among 16-19 year olds FE students. Methods: Cross-sectional self-report data were collected from 1751 students aged 16-19 at six FE settings in England and Wales. Factor analysis examined the structure of DRV victimization by gender...
November 10, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29135938/effects-of-a-lutein-and-zeaxanthin-intervention-on-cognitive-function-a-randomized-double-masked-placebo-controlled-trial-of-younger-healthy-adults
#6
Lisa M Renzi-Hammond, Emily R Bovier, Laura M Fletcher, L Stephen Miller, Catherine M Mewborn, Cutter A Lindbergh, Jeffrey H Baxter, Billy R Hammond
Background: Past studies have suggested that higher lutein (L) and zeaxanthin (Z) levels in serum and in the central nervous system (as quantified by measuring macular pigment optical density, MPOD) are related to improved cognitive function in older adults. Very few studies have addressed the issue of xanthophylls and cognitive function in younger adults, and no controlled trials have been conducted to date to determine whether or not supplementation with L + Z can change cognitive function in this population...
November 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29133598/half-lives-of-pfos-pfhxs-and-pfoa-after-end-of-exposure-to-contaminated-drinking-water
#7
Ying Li, Tony Fletcher, Daniel Mucs, Kristin Scott, Christian H Lindh, Pia Tallving, Kristina Jakobsson
BACKGROUND: Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013. OBJECTIVE: To determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives...
November 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29131659/stress-outcomes-of-four-types-of-perceived-interruptions
#8
Keaton A Fletcher, Sean M Potter, Britany N Telford
Objective We sought to define and measure four types of perceived interruptions and to examine their relationships with stress outcomes. Background Interruptions have been defined and measured in a variety of inconsistent ways. No study has simultaneously examined the subjective experience of all types of interruptions. Method First, we provide a synthesized definition and model of interruptions that aligns interruptions along two qualities: origin and degree of multitasking. Second, we create and validate a self-report measure of these four types of perceived interruptions within two samples (working undergraduate students and working engineers)...
November 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29130161/detection-of-2-alkyl-4-quinolones-using-biosensors
#9
Matthew P Fletcher, Stephen P Diggle, Miguel Cámara, Paul Williams
2-Alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-hydroxyquinoline (HHQ) are quorum-sensing signal molecules. Here we describe two methods for AQ detection and quantification that employ thin-layer chromatography (TLC) and microtiter plate assays in combination with a lux-based Pseudomonas aeruginosa AQ biosensor strain. For TLC detection, organic solvent extracts of bacterial cells or spent culture supernatants are chromatographed on TLC plates, which are then dried and overlaid with the AQ biosensor...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29126359/what-do-parents-of-children-with-autism-expect-from-participation-in-research-a-community-survey-about-early-autism-studies
#10
Sue Fletcher-Watson, Kenneth Larsen, Erica Salomone
Engagement with stakeholders is an essential part of the research process. This is particularly the case for early autism research with infant cohorts and their families, where a range of ethical issues are pertinent. Here, we report on a large survey of parents who have a child on the autism spectrum (n = 1040) which specifically probed attitudes to early autism research. The large majority of parents showed positive attitudes overall, and these were associated with greater access to services, higher service quality ratings and higher rates of intellectual disability among their children...
November 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29126296/reply-to-steptoe-et-al
#11
Soushieta Jagadesh, Tom E Fletcher, Stephen Sevalie, Ralf Weigel, Janet T Scott
No abstract text is available yet for this article.
November 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29123563/the-lives-and-works-of-john-cheyne-1777-1836-and-william-stokes-1804-1878
#12
Alexander Fletcher, Dominic Moor
Cheyne-Stokes respiration - an abnormal pattern of breathing, oscillating between hyperventilation and apnoea - was first described in the 19th century by Dr John Cheyne and Dr William Stokes. Although primarily known for this condition, both men contributed a lot more to the understanding and practice of medicine than this eponym.
November 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29121301/tissue-doppler-assessment-of-diastolic-function-and-relationship-with-mortality-in-critically-ill-septic-patients-a-systematic-review-and-meta-analysis
#13
F Sanfilippo, C Corredor, A Arcadipane, G Landesberg, A Vieillard-Baron, M Cecconi, N Fletcher
Background: Myocardial dysfunction may contribute to circulatory failure in sepsis. There is growing evidence of an association between left ventricular diastolic dysfunction (LVDD) and mortality in septic patients. Utilizing echocardiography, we know that tissue Doppler imaging (TDI) variables e' and E/e' are reliable predictors of LVDD and are useful measurements to estimate left ventricular (LV) filling pressures. Methods: We conducted a systematic review and meta-analysis to investigate the association of e' and E/e' with mortality of patients with severe sepsis or septic shock...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29118233/hairy-cell-leukemia-version-2-2018-nccn-clinical-practice-guidelines-in-oncology
#14
William G Wierda, John C Byrd, Jeremy S Abramson, Seema Bhat, Greg Bociek, Danielle Brander, Jennifer Brown, Asher Chanan-Khan, Steve E Coutre, Randall S Davis, Christopher D Fletcher, Brian Hill, Brad S Kahl, Manali Kamdar, Lawrence D Kaplan, Nadia Khan, Thomas J Kipps, Jeffrey Lancet, Shuo Ma, Sami Malek, Claudio Mosse, Mazyar Shadman, Tanya Siddiqi, Deborah Stephens, Nina Wagner, Andrew D Zelenetz, Mary A Dwyer, Hema Sundar
Hairy cell leukemia (HCL) is a rare type of indolent B-cell leukemia, characterized by symptoms of fatigue and weakness, organomegaly, pancytopenia, and recurrent opportunistic infections. Classic HCL should be considered a distinct clinical entity separate from HCLvariant (HCLv), which is associated with a more aggressive disease course and may not respond to standard HCL therapies. Somatic hypermutation in the IGHV gene is present in most patients with HCL. The BRAF V600E mutation has been reported in most patients with classic HCL but not in those with other B-cell leukemias or lymphomas...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29118113/measurement-of-micro-scale-soil-deformation-around-roots-using-four-dimensional-synchrotron-tomography-and-image-correlation
#15
S D Keyes, L Cooper, S Duncan, N Koebernick, D M McKay Fletcher, C P Scotson, A van Veelen, I Sinclair, T Roose
This study applied time lapse (four-dimensional) synchrotron X-ray computed tomography to observe micro-scale interactions between plant roots and soil. Functionally contrasting maize root tips were repeatedly imaged during ingress into soil columns of varying water content and compaction. This yielded sequences of three-dimensional densiometric data, representing time-resolved geometric soil and root configurations at the micronmetre scale. These data were used as inputs for two full-field kinematic quantification methods, which enabled the analysis of three-dimensional soil deformation around elongating roots...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29117314/assessment-of-fluorodeoxyglucose-f18-labeled-positron-emission-tomography-for-diagnosis-of-high-risk-lung-nodules
#16
Amelia W Maiga, Stephen A Deppen, Sarah Fletcher Mercaldo, Jeffrey D Blume, Chandler Montgomery, Laszlo T Vaszar, Christina Williamson, James M Isbell, Otis B Rickman, Rhonda Pinkerman, Eric S Lambright, Jonathan C Nesbitt, Eric L Grogan
Importance: Clinicians rely heavily on fluorodeoxyglucose F18-labeled positron emission tomography (FDG-PET) imaging to evaluate lung nodules suspicious for cancer. We evaluated the performance of FDG-PET for the diagnosis of malignancy in differing populations with varying cancer prevalence. Objective: To determine the performance of FDG-PET/computed tomography (CT) in diagnosing lung malignancy across different populations with varying cancer prevalence. Design, Setting, and Participants: Multicenter retrospective cohort study at 6 academic medical centers and 1 Veterans Affairs facility that comprised a total of 1188 patients with known or suspected lung cancer from 7 different cohorts from 2005 to 2015...
November 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29117051/analysis-of-patient-follow-up-at-a-level-i-trauma-center-in-ohio
#17
Brian Fletcher, Tami Meyers, Michelle Guilliams, Teresa Poliseno, Josh Burton, Michael Lieber, Ed Buggie, M Shay OʼMara
Trauma patients report being unprepared for hospital discharge. The purpose of this study was to identify follow-up compliance rates at our trauma clinic and identify factors associated with trauma patients' adherence to follow-up appointment. We recruited patients 15 years and older who were discharged from the trauma service between December 2014 and August 2015. Demographic information and injury-related variables were obtained from the trauma registry for patients who attended their follow-up and those who did not attend...
November 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29116890/a-test-and-not-treat-strategy-for-onchocerciasis-in-loa-loa-endemic-areas
#18
Joseph Kamgno, Sébastien D Pion, Cédric B Chesnais, Matthew H Bakalar, Michael V D'Ambrosio, Charles D Mackenzie, Hugues C Nana-Djeunga, Raceline Gounoue-Kamkumo, Guy-Roger Njitchouang, Philippe Nwane, Jules B Tchatchueng-Mbouga, Samuel Wanji, Wilma A Stolk, Daniel A Fletcher, Amy D Klion, Thomas B Nutman, Michel Boussinesq
Background Implementation of an ivermectin-based community treatment strategy for the elimination of onchocerciasis or lymphatic filariasis has been delayed in Central Africa because of the occurrence of serious adverse events, including death, in persons with high levels of circulating Loa loa microfilariae. The LoaScope, a field-friendly diagnostic tool to quantify L. loa microfilariae in peripheral blood, enables rapid, point-of-care identification of persons at risk for serious adverse events. Methods A test-and-not-treat strategy was used in the approach to ivermectin treatment in the Okola health district in Cameroon, where the distribution of ivermectin was halted in 1999 after the occurrence of fatal events related to L...
November 8, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29116739/gold-nanocluster-mediated-cellular-death-under-electromagnetic-radiation
#19
Anna Cifuentes-Rius, Angela Ivask, Shreya Das, Nuria Penya Auladell, Laura Fabregas, Nicholas L Fletcher, Zachary H Houston, Kristofer James Thurecht, Nicolas H Voelcker
Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy due to their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to 1 GHz electromagnetic field (microwave radiation, µW), cell viability significantly decreases thus demonstrating that Au NCs exhibit specific µW dependent cytotoxicity, likely resulting from localized heating...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29110526/mental-health-screening-of-fathers-attending-early-parenting-services-in-australia
#20
Richard Fletcher, Eileen Dowse, Jennifer St George, Tara Payling
Paternal perinatal depression and anxiety is a common, though under-recognized mental health condition experienced by men during their transition to fatherhood. An opportunity to screen for paternal mental health issues occurs when parents present for assistance with the care of their baby at early parenting services (EPSs). There are 10 EPSs located across Australia that provide specialist, multidisciplinary interventions to support parents experiencing complex parenting difficulties. Using structured telephone interviews, this qualitative study explored the views of 18 professional staff from nine EPSs regarding screening, referral processes and acceptability of screening fathers for mental health issues...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
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