keyword
MENU ▼
Read by QxMD icon Read
search

post antibiotic era

keyword
https://www.readbyqxmd.com/read/29619347/enhanced-recovery-after-surgery-eras-protocol-enables-safe-same-day-discharge-after-alloplastic-breast-reconstruction
#1
Danielle O Dumestre, Jennifer Redwood, Carmen E Webb, Claire Temple-Oberle
Background: To compare enhanced recovery after surgery (ERAS) with traditional recovery after surgery (TRAS) for patients undergoing alloplastic breast reconstruction. Methods: A retrospective chart review of 2 patient groups (ERAS and TRAS) undergoing alloplastic breast reconstruction was performed. Data were collected from 2012 to 2013 (TRAS) and from 2013 to 2016 (ERAS). The ERAS protocol included day surgery, multimodal analgesia, and preoperative anti-emetic...
November 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29569607/the-oral-microbiota-a-mechanistic-role-for-systemic-diseases
#2
G Jia, A Zhi, P F H Lai, G Wang, Y Xia, Z Xiong, H Zhang, N Che, L Ai
Human oral microbiota is the ecological community of commensal, symbiotic, and pathogenic microorganisms found in the oral cavity. Oral microbiota generally exists in the form of a biofilm and plays a crucial role in maintaining oral homeostasis, protecting the oral cavity and preventing disease development. Human oral microbiota has recently become a new focus research for promoting the progress of disease diagnosis, assisting disease treatment, and developing personalised medicines. In this review, the scientific evidence supporting the association that endogenous and exogenous factors (diet, smoking, drinking, socioeconomic status, antibiotics use and pregnancy) modulate oral microbiota...
March 23, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29568446/-de-novo-identification-of-lipid-ii-binding-lipopeptides-with-antibacterial-activity-against-vancomycin-resistant-bacteria
#3
Peter 't Hart, Thomas M Wood, Kamaleddin Haj Mohammad Ebrahim Tehrani, Roel M van Harten, Małgorzata Śleszyńska, Inmaculada Rentero Rebollo, Antoni P A Hendrickx, Rob J L Willems, Eefjan Breukink, Nathaniel I Martin
Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides. Specifically, a library of phage displayed bicyclic peptides was screened against a biomolecular target based on the bacterial cell wall precursor lipid II. In doing so we identified unique lipid II binding peptides that upon lipidation were found to be active against a range of Gram-positive bacteria including clinically relevant strains of vancomycin resistant bacteria...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29564363/acute-epiglottitis-in-the-immunocompromised-host-case-report-and-review-of-the-literature
#4
REVIEW
Cheng Chen, Mukil Natarajan, David Bianchi, Georg Aue, John H Powers
We present a case of acute epiglottitis in a 16-year-old with severe aplastic anemia. He was admitted with a history suggestive of a severe upper airway infection and an absolute neutrophil count of 0 per cubic millimeter. Despite his immunocompromised state, he presented with the classical signs and symptoms of epiglottitis. We review here the presentation and comorbidities of immunocompromised patients with epiglottitis. In addition, the appropriate choice of empirical antibiotic therapy is important for the management of epiglottitis in immunocompromised patients, especially in the post- Haemophilus influenza type B vaccination era...
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29535298/analysis-of-global-prevalence-of-antibiotic-resistance-in-acinetobacter-baumannii-infections-disclosed-a-faster-increase-in-oecd-countries
#5
Ruiqiang Xie, Xiaohua Douglas Zhang, Qi Zhao, Bo Peng, Jun Zheng
Acinetobacter baumannii is one of the most challenging nosocomial pathogens due to the emergence and widespread of antibiotic resistance. We aimed to provide the first analysis of global prevalence of antibiotic resistance in A. baumannii infections, by synthesizing data and knowledge through a systematic review. We searched studies reporting antibiotic resistance in A. baumannii infections using the Medline, Embase, Web of Science, and Cochrane databases from January 2000 to December 2016. Studies were eligible if they investigated and reported antibiotic resistance in A...
March 14, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29523862/antimicrobial-photodynamic-therapy-enhanced-by-the-peptide-aurein-1-2
#6
Laura Marise de Freitas, Esteban Nicolás Lorenzón, Norival Alves Santos-Filho, Lucas Henrique de Paula Zago, Marciana Pierina Uliana, Kleber Thiago de Oliveira, Eduardo Maffud Cilli, Carla Raquel Fontana
In the past few years, the World Health Organization has been warning that the post-antibiotic era is an increasingly real threat. The rising and disseminated resistance to antibiotics made mandatory the search for new drugs and/or alternative therapies that are able to eliminate resistant microorganisms and impair the development of new forms of resistance. In this context, antimicrobial photodynamic therapy (aPDT) and helical cationic antimicrobial peptides (AMP) are highlighted for the treatment of localized infections...
March 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29487774/invasive-streptococcus-pneumoniae-infection-causing-cardioembolic-stroke-a-clinical-proximity-to-austrian-syndrome
#7
Nilesh H Pawar, Oliver J Nickalls, Keng Leong Tan, Vui K Ho, Shin Yi Ng, Jiashen Loh
Streptococcus pneumoniae (S. pneumoniae) is a significant human bacterial pathogen and the major cause of pneumonia. In the post-antibiotic era, S. pneumoniae endocarditis is rare but carries a high risk of central nervous system (CNS) involvement. We present a case of invasive S. pneumoniae infection, which led to a cardioembolic stroke in a young man from septic emboli. Diagnosing a disseminated S. pneumoniae infection at an early stage is crucial and may improve patient outcomes.
December 18, 2017: Curēus
https://www.readbyqxmd.com/read/29454983/old-and-new-glycopeptide-antibiotics-from-product-to-gene-and-back-in-the-post-genomic-era
#8
REVIEW
Giorgia Letizia Marcone, Elisa Binda, Francesca Berini, Flavia Marinelli
Glycopeptide antibiotics are drugs of last resort for treating severe infections caused by multi-drug resistant Gram-positive pathogens. First-generation glycopeptides (vancomycin and teicoplanin) are produced by soil-dwelling actinomycetes. Second-generation glycopeptides (dalbavancin, oritavancin, and telavancin) are semi-synthetic derivatives of the progenitor natural products. Herein, we cover past and present biotechnological approaches for searching for and producing old and new glycopeptide antibiotics...
March 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29438542/discovery-and-development-of-new-antibacterial-drugs-learning-from-experience
#9
Nicole Jackson, Lloyd Czaplewski, Laura J V Piddock
Antibiotic (antibacterial) resistance is a serious global problem and the need for new treatments is urgent. The current antibiotic discovery model is not delivering new agents at a rate that is sufficient to combat present levels of antibiotic resistance. This has led to fears of the arrival of a 'post-antibiotic era'. Scientific difficulties, an unfavourable regulatory climate, multiple company mergers and the low financial returns associated with antibiotic drug development have led to the withdrawal of many pharmaceutical companies from the field...
February 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29431421/synthetic-immunobiotics-a-future-success-story-in-small-molecule-based-immunotherapy
#10
Mary J Sabulski Feigman, Marcos M Pires
Drug resistance to our current stock of antibiotics is projected to increase to levels that threaten our ability to reduce and eliminate bacterial infections, which is now considered one of the primary health care crises of the 21st century. Traditional antibiotic agents (e.g., penicillin) paved the way for massive advances in human health, but we need novel strategies to maintain the upper hand in the battle against pathogenic bacteria. Nontraditional strategies, such as targeted immunotherapies, could prove fruitful in complementing our antibiotic arsenal...
February 16, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29416857/glp1-and-gip-are-involved-in-the-action-of-synbiotics-in-broiler-chickens
#11
Pawel Antoni Kolodziejski, Maciej Sassek, Daniela Chalupka, Natalia Leciejewska, Leszek Nogowski, Pawel Mackowiak, Damian Jozefiak, Katarzyna Stadnicka, Maria Siwek, Marek Bednarczyk, Tomasz Szwaczkowski, Ewa Pruszynska-Oszmalek
Background: In order to discover new strategies to replace antibiotics in the post-antibiotic era in meat-type chicken production, two new synbiotics were tested: (Lactobacillus salivarius IBB3154 plus galactooligosaccharide (Syn1) and Lactobacillus plantarum IBB3036 plus raffinose family oligosaccharides (Syn2). Methods: The synbiotics were administered via syringe, using a special automatic system, into the egg air chamber of Cobb 500 broiler chicks on the 12th day of egg incubation (2 mg of prebiotics + 105 cfu bacteria per egg)...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29370056/the-history-and-promising-future-of-phage-therapy-in-the-military-service
#12
Daniel Gelman, Arik Eisenkraft, Nina Chanishvili, Nachman Dean, Shunit Coppenhagem Glazer, Ronen Hazan
The continuous evolvement of bacterial resistance to most, if not all currently available antibiotics is a worldwide problem. These strains, frequently isolated from military-associated environments, have created an urgent need to develop supplementary anti-infective modalities. One of the leading directions is phage therapy, which includes the administration of bacteriophages, viruses that specifically target bacteria, as bio-therapies. Though neglected in the West until recent years, bacteriophages have been widely studied and clinically administered in the former Soviet Union and Eastern Europe for over a century, where they were found to be incredibly efficient at battling numerous infectious diseases...
January 24, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29295973/protein-inspired-antibiotics-active-against-vancomycin-and-daptomycin-resistant-bacteria
#13
Mark A T Blaskovich, Karl A Hansford, Yujing Gong, Mark S Butler, Craig Muldoon, Johnny X Huang, Soumya Ramu, Alberto B Silva, Mu Cheng, Angela M Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A Bradford, June C Lee, Tomislav Karoli, Ruby Pelingon, David J Edwards, Maite Amado, Alysha G Elliott, Wanida Phetsang, Noor Huda Daud, Johan E Deecke, Hanna E Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R Betley, Andrew P G Beevers, Richard A G Smith, Jason A Roberts, David L Paterson, Matthew A Cooper
The public health threat posed by a looming 'post-antibiotic' era necessitates new approaches to antibiotic discovery. Drug development has typically avoided exploitation of membrane-binding properties, in contrast to nature's control of biological pathways via modulation of membrane-associated proteins and membrane lipid composition. Here, we describe the rejuvenation of the glycopeptide antibiotic vancomycin via selective targeting of bacterial membranes. Peptide libraries based on positively charged electrostatic effector sequences are ligated to N-terminal lipophilic membrane-insertive elements and then conjugated to vancomycin...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29288004/targeted-antimicrobial-prophylaxis-for-transrectal-ultrasound-guided-prostate-biopsy-during-active-surveillance-effect-on-hospitalization
#14
Carling Cheung, Hiten D Patel, Patricia Landis, H Ballentine Carter, Misop Han
OBJECTIVES: We investigated the effect of targeted antibiotic prophylaxis using rectal swab cultures on hospitalization for infectious complications after transrectal ultrasound-guided prostate biopsy (TRUSP). MATERIALS AND METHODS: A cohort of men (1995-2016) with prostate cancer on active surveillance receiving annual TRUSP biopsies was surveyed to determine the incidence of hospitalization for suspected postbiopsy sepsis. We compared biopsy events (i.e., unique biopsies) in the era of empiric prophylaxis to those in the era of targeted prophylaxis based on culture...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29202142/antibiotic-overprescribing-still-a-major-concern
#15
David C Fiore, Lacy P Fettic, Stephanie D Wright, Bonnie R Ferrara
Despite universal agreement that antibiotic overprescribing is a problem, the practice continues to vex us. Antibiotic use--whether appropriate or not--has been linked to rising rates of antimicrobial resistance, disruption of the gut microbiome leading to Clostridium difficile infections, allergic reactions, and increased health care costs. And yet, physicians continue to overprescribe this class of medication. A 2016 Centers for Disease Control and Prevention report estimates that at least 30% of antibiotics prescribed in US outpatient settings are unnecessary...
December 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29202138/effects-and-time-kill-assessment-of-amoxicillin-used-in-combination-with-chloramphenicol-against-bacteria-of-clinical-importance
#16
Olufunmiso O Olajuyigbe, Roger M Coopoosamy, Anthony J Afolayan
With the emergence of multidrug-resistant organisms in an era when drug development faces challenges causing pharmaceutical companies to curtail or abandon research on anti-infective agents, the use of combined existing antimicrobial agents may be an alternative. This study evaluated the effects of combining amoxicillin and chloramphenicol, to which many bacteria have become resistant, in vitro against Gram positive and Gram negative bacteria by agar diffusion, checkerboard and time-kill assays. The test isolates were susceptible to amoxicillin with minimum inhibitory concentrations (MICs) ranging between 0...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29177092/genome-guided-identification-of-novel-head-to-tail-cyclized-antimicrobial-peptides-exemplified-by-the-discovery-of-pumilarin
#17
Auke J van Heel, Manuel Montalban-Lopez, Quentin Oliveau, Oscar P Kuipers
The need for novel antibiotics in an era where antimicrobial resistance is on the rise, and the number of new approved antimicrobial drugs reaching the market is declining, is evident. The underused potential of post-translationally modified peptides for clinical use makes this class of peptides interesting candidates. In this study, we made use of the vast amounts of available genomic data and screened all publicly available prokaryotic genomes (~3000) to identify 394 novel head-to-tail cyclized antimicrobial peptides...
October 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29165505/-evolutionary-interactions-as-a-possible-mechanism-of-drug-interactions-an-approach-to-the-control-of-antibiotic-resistant-bacteria
#18
Héctor Holguín, Pedro Amariles, William Ospina
In the 21st century, the world is facing a post-antibiotic era, in which the appearance of infections with a minor or no therapeutic alternative is common. In this context, it is essential to implement measures that optimize the available therapeutic tool, thus generating new strategies that strengthen the fight against growing bacterial resistance. The evolutionary interactions suggest that the development of sensitivity or resistance of a microorganism to an antimicrobial will have an inverse effect (collateral sensitivity) or similar (cross resistance) in a second antimicrobial that is involved in this system...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29158030/the-role-of-ayurveda-management-in-preventing-surgical-site-infections-instead-of-surgical-antibiotic-prophylaxis
#19
Subhash Yadav, Sanjay Jain, Jatinder Chaudhary, Rahul Bansal, Manoj Sharma
It is probably for the first time in the history of modern surgery that Benign Prostate Hyperplasia (BPH) surgery which belongs to 'clean contaminated' class and requires at least 3 doses of prophylactic antibiotic as per recommendations by American Urology Association, was done without the use of any as the patient had a history of severe intolerance to them. The case was an 83 year old male patient presenting with acute urinary retention. He was a known case of BPH being managed continuously on Ayurvedic therapy for many years...
October 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29126217/change-in-pneumococcus-serotypes-but-not-mortality-or-morbidity-in-pre-and-post-13-valent-polysaccharide-conjugate-vaccine-era-epidemiology-in-a-pediatric-intensive-care-unit-over-10-years
#20
Kam Lun Hon, King Hang Chan, Pak Long Ko, Michelle Ho Yan Cheung, Kathy Yin C Tsang, Lawrence C N Chan, Renee W Y Chan, Ting Fan Leung, Margaret Ip
Aim: Pneumococcus is a common commensal and an important pathogen among children for which immunization is available. Some serotypes occasionally cause severe pneumococcal disease with high mortality and morbidity. We reviewed all pneumococcal serotypes and mortality/morbidity in a pediatric intensive care unit (PICU) following universal pneumococcal conjugate vaccine (PCV) immunization. Methods: A 13-valent PCV was introduced in the universal immunization program in late 2011 in Hong Kong...
November 6, 2017: Journal of Tropical Pediatrics
keyword
keyword
105056
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"