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https://www.readbyqxmd.com/read/28070894/a-phase-1-open-label-randomized-crossover-study-evaluating-the-bioavailability-of-tas-102-trifluridine-tipiracil-tablets-relative-to-an-oral-solution-containing-equivalent-amounts-of-trifluridine-and-tipiracil
#1
Carlos R Becerra, Kenichiro Yoshida, Hirokazu Mizuguchi, Manish Patel, Daniel Von Hoff
TAS-102 (trifluridine/tipiracil) is composed of an antineoplastic thymidine-based nucleoside analogue trifluridine (FTD), and a thymidine phosphorylase inhibitor, tipiracil (TPI), at a molar ratio of 1:0.5 (weight ratio, 1:0.471). A phase 1 study evaluated relative bioavailability of TAS-102 tablets compared with an oral solution containing equivalent amounts of FTD and TPI. In an open-label, 2-sequence, 3-period, crossover bioavailability study (part 1), patients 18 years or older with advanced solid tumors were randomized to receive TAS-102 tablets (60 mg; 3 × 20-mg tablets) on day 1 and TAS-102 oral solution (60 mg) on days 8 and 15, or the opposite sequence...
January 9, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28069205/study-of-a-laboratory-scaled-new-method-for-the-accelerated-continuous-ageing-of-wine-spirits-by-applying-ultrasound-energy
#2
M J Delgado-González, M M Sánchez-Guillén, M V García-Moreno, M C Rodríguez-Dodero, C García-Barroso, D A Guillén-Sánchez
During the ageing of brandies, many physicochemical processes take place involving the distilled spirit and the wood of the casks. Because of these reactions, the polyphenolic content of brandies and their content of organic acids increase with the ageing. These reactions are slow, and the ageing of high-quality brandies takes several years. In this paper, the development of a system that uses the circulation of the wine distillate through encapsulated American oak chips and the application of ultrasound energy with the aim of producing aged wine spirits has been carried out, and the influences of the operation variables over the characteristics of the produced drink have been measured...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28049541/the-presence-of-giardia-intestinalis-in-donkeys-equus-asinus-in-china
#3
Xiao-Xuan Zhang, Fu-Kai Zhang, Fa-Cai Li, Jun-Ling Hou, Wen-Bin Zheng, Shuai-Zhi Du, Quan Zhao, Xing-Quan Zhu
BACKGROUND: Giardia intestinalis is one of the most important zoonotic enteric parasites. As no information regarding prevalence and genotype of G. intestinalis in donkeys (Equus asinus) in China is available, 181 faecal samples from 48 donkeys from Jilin Province, from 104 from Shandong Province and from 29 from Liaoning Province were examined between May and December 2015. FINDINGS: Twenty-eight (15.47%) out of 181 donkey samples were tested G. intestinalis-positive by nested amplification of the triosephosphate isomerase (tpi) gene...
January 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28017653/measurement-of-the-inter-tablet-coating-uniformity-of-a-pharmaceutical-pan-coating-process-with-combined-terahertz-and-optical-coherence-tomography-in-line-sensing
#4
Hungyen Lin, Yue Dong, Daniel Markl, Bryan M Williams, Yalin Zheng, Yaochun Shen, J Axel Zeitler
We present in-line coating thickness measurements acquired simultaneously using two independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT). Both techniques are sufficiently fast to resolve the coating thickness of individual pharmaceutical tablets in-situ during the film coating operation and both techniques are direct structural imaging techniques that do not require multivariate calibration. The TPI sensor is suitable to measure coatings greater than 50 μm and can penetrate through thick coatings even in the presence of pigments over a wide range of excipients...
December 22, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28004318/analysis-of-3d-prints-by-x-ray-computed-microtomography-and%C3%A2-terahertz-pulsed-imaging
#5
Daniel Markl, J Axel Zeitler, Cecilie Rasch, Maria Høtoft Michaelsen, Anette Müllertz, Jukka Rantanen, Thomas Rades, Johan Bøtker
PURPOSE: A 3D printer was used to realise compartmental dosage forms containing multiple active pharmaceutical ingredient (API) formulations. This work demonstrates the microstructural characterisation of 3D printed solid dosage forms using X-ray computed microtomography (XμCT) and terahertz pulsed imaging (TPI). METHODS: Printing was performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA). The structures were examined by XμCT and TPI. Liquid self-nanoemulsifying drug delivery system (SNEDDS) formulations containing saquinavir and halofantrine were incorporated into the 3D printed compartmentalised structures and in vitro drug release determined...
December 21, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27999583/structural-basis-for-redox-regulation-of-cytoplasmic-and-chloroplastic-triosephosphate-isomerases-from-arabidopsis-thaliana
#6
Laura M López-Castillo, Pedro Jiménez-Sandoval, Noe Baruch-Torres, Carlos H Trasviña-Arenas, Corina Díaz-Quezada, Samuel Lara-González, Robert Winkler, Luis G Brieba
In plants triosephosphate isomerase (TPI) interconverts glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the Calvin-Benson cycle. The nuclear genome of land plants encodes two tpi genes, one gene product is located in the cytoplasm and the other is imported into the chloroplast. Herein we report the crystal structures of the TPIs from the vascular plant Arabidopsis thaliana (AtTPIs) and address their enzymatic modulation by redox agents. Cytoplasmic TPI (cTPI) and chloroplast TPI (pdTPI) share more than 60% amino acid identity and assemble as (β-α)8 dimers with high structural homology...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27934806/molecular-appraisal-of-intestinal-parasitic-infection-in-transplant-recipients
#7
Pooja Yadav, Shehla Khalil, Bijay Ranjan Mirdha
BACKGROUND & OBJECTIVES: Diarrhoea is the main clinical manifestation caused by intestinal parasitic infections in patients, with special reference to transplant recipients who require careful consideration to reduce morbidity and mortality. Further, molecular characterization of some important parasites is necessary to delineate the different modes of transmission to consider appropriate management strategies. We undertook this study to investigate the intestinal parasitic infections in transplant recipients with or without diarrhoea, and the genotypes of the isolated parasites were also determined...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27885466/molecular-epidemiology-and-multilocus-sequence-analysis-of-potentially-zoonotic-giardia-spp-from-humans-and-dogs-in-jamaica
#8
Mellesia F Lee, Paul Cadogan, Sarah Eytle, Sonia Copeland, Julia Walochnik, John F Lindo
Giardia spp. are the causative agents of intestinal infections in a wide variety of mammals including humans and companion animals. Dogs may be reservoirs of zoonotic Giardia spp.; however, the potential for transmission between dogs and humans in Jamaica has not been studied. Conventional PCR was used to screen 285 human and 225 dog stool samples for Giardia targeting the SSU rDNA gene followed by multilocus sequencing of the triosephosphate isomerase (tpi), glutamate dehydrogenase (gdh), and β-giardin (bg) genes...
January 2017: Parasitology Research
https://www.readbyqxmd.com/read/27885465/multilocus-sequence-analysis-of-giardia-spp-isolated-from-patients-with-diarrhea-in-austria
#9
Mellesia F Lee, Herbert Auer, John F Lindo, Julia Walochnik
Giardia duodenalis is a protozoan parasite causing intestinal infections in a wide range of mammals. Two distinct assemblages, A and B, infect humans predominantly; however, both are believed to be generally zoonotic. Giardia strains associated with infections in Austria have not been investigated at the molecular level. In this study, 65 human stool samples microscopically positive for Giardia spp. were subjected to DNA isolation and nested PCR targeting fragments of the glutamate dehydrogenase (gdh), triose phosphate isomerase (tpi), and beta-gardin (bg) genes...
November 25, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27877179/genome-wide-identification-of-micrornas-and-their-targets-in-the-leaves-and-fruits-of-eucommia-ulmoides-using-high-throughput-sequencing
#10
Lin Wang, Hongyan Du, Ta-Na Wuyun
MicroRNAs (miRNAs), a group of endogenous small non-coding RNAs, play important roles in plant growth, development, and stress response processes. Eucommia ulmoides Oliver (hardy rubber tree) is one of the few woody plants capable of producing trans-1, 4-polyisoprene (TPI), also known as Eu-rubber, which has been utilized as an industrial raw material and is extensively cultivated in China. However, the mechanism of TPI biosynthesis has not been identified in E. ulmoides. To characterize small RNAs and their targets with potential biological roles involved in the TPI biosynthesis in E...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27876969/molecular-detection-of-giardiasis-among-children-at-cairo-university-pediatrics-hospitals
#11
Marwa A Ghieth, Magd A Kotb, Enas Y Abu-Sarea, Ayman A El-Badry
Giardiasis is a prevailing intestinal disease in children. This study aimed to determine molecular prevalence of Giardia intestinalis in children attending Cairo University Pediatrics Hospitals, using copro-PCR assays, conventional methods and to evaluate diagnostic effectiveness of used tests. 229 fecal samples were collected from children suffering from gastrointestinal symptoms and examined for Giardia by microscopy, Immuno-chromatographic test (ICT), copro-DNA using two PCR assays targeting tpi [nested-PCR (nPCR)] and 18S [conventional-PCR (cPCR)] genes...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27852150/frequency-diagnostic-performance-of-coproantigen-detection-and-genotyping-of-the-giardia-among-patients-referred-to-a-multi-level-teaching-hospital-in-northern-india
#12
Ujjala Ghoshal, Ratnakar Shukla, Priyannk Pant, Uday C Ghoshal
Giardiasis, a common gastrointestinal parasitic infection in tropics, is diagnosed on stool microscopy (gold standard); however, its sensitivity is low due to intermittent fecal shedding. Coproantigen detection (ELISA) is useful but requires further evaluation. We aimed to study: (a) detection of Giardia by stool microscopy and/or coproantigen, (b) diagnostic performance of fecal antigen detection and microscopy, and c) genotypic characterization of G. lamblia using PCR specific for triose phosphate isomerase (tpi) gene...
October 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27846985/array-of-biosensors-for-discrimination-of-grapes-according-to-grape-variety-vintage-and-ripeness
#13
C Medina-Plaza, J A de Saja, J A Fernández-Escudero, E Barajas, G Medrano, M L Rodriguez-Mendez
A bioelectronic tongue based on nanostructured biosensors specific for the simultaneous detection of sugars and phenols has been developed. The array combined oxidases and dehydrogenases immobilized on a lipidic layer prepared using the Langmuir-Blodgett technique where Glucose oxidase, d-Fructose dehydrogenase, Tyrosinase or Laccase were imbibed. A phthalocyanine was co-immobilized in the sensing layer and used as electron mediator. The array thus formed has been used to analyze grapes and provides global information about the samples while providing specific information about their phenolic and their sugar content...
December 1, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27843774/long-term-clinical-outcome-of-peripheral-nerve-stimulation-for-chronic-headache-and-complication-prevention
#14
Linqiu Zhou, Avi Ashkenazi, Joseph W Smith, Na Jen, Timothy R Deer, Chen Zhou
BACKGROUND: Subcutaneous peripheral nerve stimulation (PNS) has emerged as a useful tool in the treatment of intractable headaches. However, complications such as skin erosion, infection and lead migration have adversely affected clinical outcome, and occasionally led to treatment cessation. OBJECTIVES: Here we report the results of peripheral nerve stimulator implantation performed on 24 patients with various chronic headaches at our center over a period of 9 years...
August 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27832466/cost-effectiveness-analysis-of-the-temporary-percutaneous-ileostomy-for-faecal-diversion-after-colorectal-resection-in-elderly
#15
W Bugiantella, F Rondelli, L Mariani, A Polistena, A Sanguinetti, N Avenia, E Mariani
BACKGROUND: Conventional loop ileostomy (CLI) is a suitable procedure for transitory faecal diversion after colorectal anastomosis, but it causes relevant morbidities (dehydration, discomfort, peristomal infections) and requires a second operation to be closed. We already described an alternative technique of temporary percutaneous ileostomy (TPI), which can be removed without surgery. AIMS: We analyse the outcomes and the costs of the TPI in protecting low colorectal anastomosis in elderly, compared to the CLI...
November 10, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27828417/two-stage-optical-recording-photoinduced-birefringence-and-surface-mediated-bits-storage-in-bisazo-containing-copolymers-towards-ultrahigh-data-memory
#16
Yanlei Hu, Dong Wu, Jiawen Li, Wenhao Huang, Jiaru Chu
Ultrahigh density data storage is in high demand in the current age of big data and thus motivates many innovative storage technologies. Femtosecond laser induced multi-dimensional optical data storage is an appealing method to fulfill the demand of ultrahigh storage capacity. Here we report a femtosecond laser induced two-stage optical storage in bisazobenzene copolymer films by manipulating the recording energies. Different mechanisms can be selected for specified memory use: two-photon isomerization (TPI) and laser induced surface deformation...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27760188/genotyping-and-descriptive-proteomics-of-a-potential-zoonotic-canine-strain-of-giardia-duodenalis-infective-to-mice
#17
Camila Henriques Coelho, Adriana Oliveira Costa, Ana Carolina Carvalho Silva, Maíra Mazzoni Pucci, Angela Vieira Serufo, Haendel Goncalves Nogueira Oliveira Busatti, Maurício Durigan, Jonas Perales, Alex Chapeaurouge, Daniel Almeida da Silva E Silva, Maria Aparecida Gomes, Juliano Simões Toledo, Steven M Singer, Rosiane A Silva-Pereira, Ana Paula Fernandes
The zoonotic potential of giardiasis, as proposed by WHO since the late 70's, has been largely confirmed in this century. The genetic assemblages A and B of Giardia duodenalis are frequently isolated from human and canine hosts. Most of the assemblage A strains are not infective to adult mice, which can limit the range of studies regarding to biology of G. duodenalis, including virulence factors and the interaction with host immune system. This study aimed to determine the infectivity in mice of an assemblage A Giardia duodenalis strain (BHFC1) isolated from a dog and to classify the strain in sub-assemblages (AI, AII, AIII) through the phylogenetic analysis of beta-giardin (bg), triose phosphate isomerase (tpi) and glutamate dehydrogenase (gdh) genes...
2016: PloS One
https://www.readbyqxmd.com/read/27737706/prevalence-and-multilocus-genotyping-of-giardia-duodenalis-in-dairy-calves-in-xinjiang-northwestern-china
#18
Meng Qi, Haiyan Wang, Bo Jing, Rongjun Wang, Fuchun Jian, Changshen Ning, Longxian Zhang
BACKGROUND: Giardia duodenalis is an important protozoan parasite. It is an established zoonotic pathogen and dairy calves have been implicated as one of the most important sources of human infection. This study was conducted to assess the prevalence and multilocus genotyping of G. duodenalis in dairy calves in the Xinjiang Uyghur Autonomous Region, northwestern China. FINDINGS: A total of 514 fresh fecal samples were randomly collected from dairy calves in 15 farms in Xinjiang, 13...
October 13, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27721038/saw-marks-in-bones-a-study-of-170-experimental-false-start-lesions
#19
Luísa Nogueira, Gérald Quatrehomme, Christophe Rallon, Pascal Adalian, Véronique Alunni
This experimental study examined false starts because these are seldom discussed in the forensic literature and usually concern animal bones rather than human bones. We created 170 experimental false starts (50 on pig femurs and 120 on human femurs) using five different saws (4 with an alternating set of teeth, and one with a wavy set). Teeth per inch (TPI) ranged from 7 to 24. Saws were classified as either rip saws or universal saws. The bone lesions were studied using stereomicroscopy. This study focused on three features that are easily observed with a stereomicroscope: the minimum width of the kerf, the profile of the lesions (concave or convex), and the shape of the edges (narrow-wide pattern, necking in the middle, or straight pattern)...
November 2016: Forensic Science International
https://www.readbyqxmd.com/read/27706146/characterisation-of-reproduction-associated-genes-and-peptides-in-the-pest-land-snail-theba-pisana
#20
Michael J Stewart, Tianfang Wang, Bradley I Harding, U Bose, Russell C Wyeth, Kenneth B Storey, Scott F Cummins
Increased understanding of the molecular components involved in reproduction may assist in understanding the evolutionary adaptations used by animals, including hermaphrodites, to produce offspring and retain a continuation of their lineage. In this study, we focus on the Mediterranean snail, Theba pisana, a hermaphroditic land snail that has become a highly invasive pest species within agricultural areas throughout the world. Our analysis of T. pisana CNS tissue has revealed gene transcripts encoding molluscan reproduction-associated proteins including APGWamide, gonadotropin-releasing hormone (GnRH) and an egg-laying hormone (ELH)...
2016: PloS One
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