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https://www.readbyqxmd.com/read/29155559/crafting-of-neuroprotective-octapeptide-from-taxol-binding-pocket-of-%C3%AE-tubulin
#1
Prasenjit Mondal, Gaurav Das, Juhee Khan, Krishnangsu Pradhan, Surajit Ghosh
Microtubules play crucial role in maintaining the shape and function of neurons. During progression of Alzheimer's disease (AD), severe destabilization of microtubule occurs, which leads to the permanent disruption of signal transduction process and memory loss. Thus, microtubule stabilization is one of the key requirements for the treatment of AD. Taxol, a microtubule stabilizing anti-cancer drug has been considered as potential anti-AD drug but never tested in AD patients, likely because of its' toxic nature and poor brain exposure...
November 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29132832/the-proposed-concordance-statistic-for-benefit-provided-a-useful-metric-when-modeling-heterogeneous-treatment-effects
#2
David van Klaveren, Ewout W Steyerberg, Patrick W Serruys, David M Kent
OBJECTIVES: Clinical prediction models that support treatment decisions are usually evaluated for their ability to predict the risk of an outcome rather than treatment benefit - the difference between outcome risk with versus without therapy. We aimed to define performance metrics for a model's ability to predict treatment benefit. STUDY DESIGN AND SETTING: We analyzed data of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial, and of 3 recombinant tissue plasminogen activator trials...
November 10, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29125200/refreshing-rubbers-as-customized-photothermal-conversion-materials-through-post-darkening-modeling-production
#3
Ruiting Li, Zhen Wang, Peng Han, Yonglin He, Xiaohong Zhang, Yapei Wang
Organic conjugated polymers with low energy bandgap are rising as a particular class of NIR photothermal conversion materials. Yet these polymers routinely possess high phase transition temperature due to the rigid skeleton and strong intermolecular interaction. Rarely conjugated polymers can be thermally processed at low temperature, especially below 100°C. This work formulates a concept of post-darkening modeling production (p-DMP) by which the thermoplastic non-conjugated trans-polyisoprene (TPI) is refreshed into a photo-thermal conversion material with high light use efficiency...
November 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29119052/synergistic-anticancer-activity-of-a-novel-oral-chemotherapeutic-agent-containing-trifluridine-and-tipiracil-in-combination-with-anti-pd-1-blockade-in-microsatellite-stable-type-murine-colorectal-cancer-cells
#4
Norihiko Suzuki, Hiroshi Tsukihara, Fumio Nakagawa, Takashi Kobunai, Teiji Takechi
Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo. It is used to treat patients with unresectable advanced or recurrent colorectal cancer that is refractory to standard therapies. We investigated the anticancer activity of FTD/TPI combined with anti-mouse programed cell death 1 (PD-1) monoclonal antibody (mAb) against CMT-93 cells, which are microsatellite stable (MSS)-type murine colorectal cancer cells...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29102082/design-and-synthesis-of-p-carborane-containing-sulfamates-as-multitarget-anti-breast-cancer-agents
#5
Asako Kaise, Kiminori Ohta, Chinami Shirata, Yasuyuki Endo
The development of multitarget anticancer agents is of high interest to medicinal chemists in terms of overcoming drug resistance and preventing cancer-cell migration. Based on the structure of the potent carborane-containing estrogen BE120, non-steroidal multitarget anti-breast cancer agent candidates 1a-1j were designed and synthesized. Compound 1f shows potent STS-inhibitory activity (IC50 = 1.8 μM), cell-growth-inhibitory (CGI) activity against 39 human cancer cell lines (MG-MID = 2.8 μM), and tubulin-polymerization-inhibitory (TPI) activity...
October 16, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29080768/multilocus-genotyping-of-giardia-duodenalis-in-tibetan-sheep-and-yaks-in-qinghai-china
#6
Yue Jin, Jilan Fei, Jinzhong Cai, Xiaolan Wang, Na Li, Yaqiong Guo, Yaoyu Feng, Lihua Xiao
Giardia duodenalis is a common gastrointestinal protozoon in mammals. Although many studies have been reported on the distribution of G. duodenalis genotypes in sheep and cattle raised under intensive farming, few studies are available on the distribution of G. duodenalis in Tibetan sheep and yaks, which are raised free ranging in a continental plateau climate. In this study, 495 fecal specimens from Tibetan sheep and 605 from yaks were collected from eight counties in Qinghai, China and analyzed for G. duodenalis by PCR targeting the β-giardin (bg), glutamate dehydrogenase (gdh), and triosephosphate isomerase (tpi) genes...
November 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29058256/simultaneous-detection-and-characterization-of-toxigenic-clostridium-difficile-directly-from-clinical-stool-specimens
#7
Hanjiang Lai, Chen Huang, Jian Cai, Julian Ye, Jun She, Yi Zheng, Liqian Wang, Yelin Wei, Weijia Fang, Xianjun Wang, Yi-Wei Tang, Yun Luo, Dazhi Jin
We employed a multiplex polymerase chain reaction (PCR) coupled with capillary electrophoresis (mPCR-CE) targeting six Clostridium difficile genes, including tpi, tcdA, tcdB, cdtA, cdtB, and a deletion in tcdC for simultaneous detection and characterization of toxigenic C. difficile directly from fecal specimens. The mPCR-CE had a limit of detection of 10 colony-forming units per reaction with no cross-reactions with other related bacterial genes. Clinical validation was performed on 354 consecutively collected stool specimens from patients with suspected C...
October 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29056701/prevalence-of-selected-zoonotic-and-vector-borne-agents-in-dogs-and-cats-on-the-pine-ridge-reservation
#8
A Valeria Scorza, Michael R Lappin
The prevalence of intestinal parasites and vector-borne agents of dogs and cats in the Pine Ridge Reservation, South Dakota were determined. Fecal samples (84 dogs, 9 cats) were examined by centrifugal floatation and by immunofluorescence assay (FA) for Giardia and Cryptosporidium. PCR was performed on Giardia [beta-giardin (bg), triose phosphate isomerase (tpi), glutamate dehydrogenase genes (gdh)] and Cryptosporidium [heat shock protein-70 gene (hsp)] FA positive samples. Cat sera (n = 32) were tested for antibodies against Bartonella spp...
September 4, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29056685/prevalence-and-multilocus-genotyping-analysis-of-cryptosporidium-and-giardia-isolates-from-dogs-in-chiang-mai-thailand
#9
Sahatchai Tangtrongsup, A Valeria Scorza, John S Reif, Lora R Ballweber, Michael R Lappin, Mo D Salman
The occurrence and zoonotic potential of Cryptosporidium spp. and Giardia duodenalis isolated from dogs in Chiang Mai, Thailand were determined. Fecal samples were collected from 109 dogs between July and August 2008. Cryptosporidium spp. infection was determined by immunofluorescent assay (IFA), PCR assays that amplify Cryptosporidium heat-shock protein 70 kDa (hsp70), and two PCR assays that amplify a small subunit-ribosomal RNA (SSU-rRNA). Giardiaduodenalis infection was identified using zinc sulfate centrifugal flotation, IFA, and four PCR assays that amplify the Giardia glutamate dehydrogenase (gdh), beta-giardin (bg), and generic and dog-specific assays of triosephosphate isomerase (tpi) genes...
May 10, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29056403/a-non-destructive-method-for-quality-control-of-the-pellet-distribution-within-a-mups-tablet-by-terahertz-pulsed-imaging
#10
Anna Novikova, Daniel Markl, J Axel Zeitler, Thomas Rades, Claudia S Leopold
Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform...
October 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29024819/a-modular-metabolic-engineering-approach-for-the-production-of-1-2-propanediol-from-glycerol-by-saccharomyces-cerevisiae
#11
Zia-Ul Islam, Mathias Klein, Maximilian R Aßkamp, Anders S R Ødum, Elke Nevoigt
Compared to sugars, a major advantage of using glycerol as a feedstock for industrial bioprocesses is the fact that this molecule is more reduced than sugars. A compound whose biotechnological production might greatly profit from the substrate's higher reducing power is 1,2-propanediol (1,2-PDO). Here we present a novel metabolic engineering approach to produce 1,2-PDO from glycerol in S. cerevisiae. Apart from implementing the heterologous methylglyoxal (MG) pathway for 1,2-PDO formation from dihydroxyacetone phosphate (DHAP) and expressing a heterologous glycerol facilitator, the employed genetic modifications included the replacement of the native FAD-dependent glycerol catabolic pathway by the 'DHA pathway' for delivery of cytosolic NADH and the reduction of triosephosphate isomerase (TPI) activity for increased precursor (DHAP) supply...
October 9, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29020609/overview-of-pat-process-analysers-applicable-in-monitoring-of-film-coating-unit-operations-for-manufacturing-of-solid-oral-dosage-forms
#12
REVIEW
Klemen Korasa, Franc Vrečer
Over the last two decades, regulatory agencies have demanded better understanding of pharmaceutical products and processes by implementing new technological approaches, such as process analytical technology (PAT). Process analysers present a key PAT tool, which enables effective process monitoring, and thus improved process control of medicinal product manufacturing. Process analysers applicable in pharmaceutical coating unit operations are comprehensibly described in the present article. The review is focused on monitoring of solid oral dosage forms during film coating in two most commonly used coating systems, i...
October 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28992563/potential-role-of-polymorphisms-in-the-transporter-genes-ent1-and-mate1-oct2-in-predicting-tas-102-efficacy-and-toxicity-in-patients-with-refractory-metastatic-colorectal-cancer
#13
Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Wu Zhang, Dongyun Yang, Vincenzo Dadduzio, Lisa Salvatore, Beatrice Borelli, Filippo Pietrantonio, Yan Ning, Satoshi Okazaki, Martin D Berger, Yuji Miyamoto, Roel Gopez, Afsaneh Barzi, Toshiharu Yamaguchi, Fotios Loupakis, Heinz-Josef Lenz
BACKGROUND: Trifluridine (FTD) is an active cytotoxic component of the metastatic colorectal cancer (mCRC) drug TAS-102, and thymidine phosphorylase inhibitor (TPI) inhibits the rapid degradation of FTD. We tested whether single nucleotide polymorphisms (SNPs) in genes involved in FTD metabolism and TPI excretion could predict outcome in patients with mCRC treated with TAS-102. PATIENTS AND METHODS: We investigated three different cohorts: a training cohort (n = 52) and a testing cohort (n = 129) both receiving TAS-102 and a control cohort (n = 52) receiving regorafenib...
October 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28987079/effectiveness-of-biofield-therapy-for-patients-diagnosed-with-fibromyalgia
#14
Fernando Sarmento, Hideaki Tanaka, Eduarda Cordeiro, Kiyoshi Suzuki
Context • Fibromyalgia (FM) is a disorder with an unknown etiology; symptoms include physical and psychological stress, widespread chronic pain, insomnia, and depression. Mind-body medicine and aerobic exercise have shown positive effects for symptom control. Several studies have reported positive effects for biofield therapy for FM, but when other studies have compared the treatment with a sham control, they have not found those beneficial effects. Objective • The study intended to examine the effects of a biofield therapy called Okada purifying therapy on patients' FM symptoms...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28986721/does-trade-matter-for-carbon-emissions-in-oecd-countries-evidence-from-a-new-trade-openness-measure
#15
Giray Gozgor
This paper analyzes the impacts of the per capita income, the per capita energy consumption, and the trade openness on the level of per capita carbon emissions in the panel dataset of 35 Organization for Economic Cooperation and Development (OECD) countries over the period 1960-2013. Along with the nominal trade openness, the paper uses a different trade openness measure, so called as the "trade potential index" (TPI). To the best of our knowledge, this is the first paper that uses the TPI in the empirical environmental Kuznets curve (EKC) hypothesis literature...
October 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28982911/a-proposal-for-progression-free-survival-assessment-in-patients-with-early-progressive-cancer
#16
Takanori Tanase, Chikuma Hamada, Takayuki Yoshino, Atsushi Ohtsu
BACKGROUND/AIM: Progression-free survival (PFS), which is evaluated in oncology clinical trials, is determined based on tumor progression evaluated according to an assessment schedule. There is possibly a bias in median PFS and hazard ratio (HR) for PFS depending on the assessment schedule referring to randomized controlled trials (RCTs) in patients with metastatic colorectal cancer. MATERIALS AND METHODS: We re-analyzed the PFS in the FTD/TPI phase 2 trial by changing the assessment schedule...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28971042/extracorporeal-shock-wave-therapy-versus-trigger-point-injection-in-the-treatment-of-myofascial-pain-syndrome-in-the-quadratus-lumborum
#17
Jin Oh Hong, Joon Sang Park, Dae Geun Jeon, Wang Hyeon Yoon, Jung Hyun Park
OBJECTIVE: To compare the effectiveness of extracorporeal shock wave therapy (ESWT) and trigger point injection (TPI) for the treatment of myofascial pain syndrome in the quadratus lumborum. METHODS: In a retrospective study at our institute, 30 patients with myofascial pain syndrome in the quadratus lumborum were assigned to ESWT or TPI groups. We assessed ESWT and TPI treatment according to their affects on pain relief and disability improvement. The outcome measures for the pain assessment were a visual analogue scale score and pain pressure threshold...
August 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28941990/molecular-characterization-of-cryptosporidium-and-giardia-in-farmers-and-their-ruminant-livestock-from-the-coastal-savannah-zone-of-ghana
#18
Sylvia Afriyie Squire, Rongchang Yang, Ian Robertson, Irene Ayi, Una Ryan
Cryptosporidium and Giardia are major causes of diarrhoea in developing countries including Ghana, however, nothing is known about the species and subtypes of Cryptosporidium and Giardia in farmers and their ruminant livestock in this country. A total of 925 faecal samples from humans (n=95), cattle (n=328), sheep (n=217) and goats (n=285), were screened for Cryptosporidium and Giardia by quantitative PCR (qPCR) at the 18S rRNA and glutamate dehydrogenase (gdh) loci respectively. Cryptosporidium positives were typed by sequence analysis of 18S and 60kDa glycoprotein (gp60) loci amplicons...
September 21, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28923217/current-challenges-in-the-management-of-breast-cancer-brain-metastases
#19
REVIEW
Ciara C O'Sullivan, Nicole N Davarpanah, Jame Abraham, Susan E Bates
Approximately 50% of patients with advanced human epidermal growth factor 2 (HER2)-positive breast cancer and triple-negative breast cancer (TNBC) ultimately develop breast cancer brain metastases (BCBM), which are associated with significant morbidity and mortality. The advent of HER2-directed therapy resulted in greatly improved survival outcomes, but unfortunately at the price of an increased cumulative incidence of BCBM. We review challenges in the management of BCBM, and potential treatment strategies, including novel agents such as poly-adenosine diphosphate (ADP) ribose polymerase (PARP) inhibitors (olaparib, veliparib), cyclin-dependent kinase 4/6 (CDK4/6) inhibitors (palbociclib, abemaciclib), and taxane derivatives (eg, ANG1005 and TPI-287)...
April 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28910395/multilocus-genotyping-of-giardia-duodenalis-in-captive-non-human-primates-in-sichuan-and-guizhou-provinces-southwestern-china
#20
Zhijun Zhong, Yinan Tian, Wei Li, Xiangming Huang, Lei Deng, Suizhong Cao, Yi Geng, Hualin Fu, Liuhong Shen, Haifeng Liu, Guangneng Peng
Giardia duodenalis is a common human and animal pathogen. It has been increasingly reported in wild and captive non-human primates (NHPs) in recent years. However, multilocus genotyping information for G. duodenalis infecting NHPs in southwestern China is limited. In the present study, the prevalence and multilocus genotypes (MLGs) of G. duodenalis in captive NHPs in southwestern China were determined. We examined 207 fecal samples from NHPs in Sichuan and Guizhou provinces, and 16 specimens were positive for G...
2017: PloS One
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