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https://www.readbyqxmd.com/read/28426271/factors-associated-with-the-efficacy-of-trigger-point-injection-in-advanced-cancer-patients
#1
Hideaki Hasuo, Kenji Kanbara, Tetsuya Abe, Hiroko Sakuma, Mikihiko Fukunaga
BACKGROUND: Few studies have reported the efficacy of trigger point injection (TPI) to myofascial trigger points (MTrPs) in advanced cancer patients. Factors that are associated with TPI efficacy have not yet been elucidated. OBJECTIVE: The study was aimed at evaluating factors that are associated with TPI efficacy to MTrPs in advanced cancer patients. DESIGN: Factors that are associated with TPI efficacy were retrospectively identified based on a comparison between clinically relevant responders and nonresponders by using multivariate regression analysis...
April 20, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28409901/comparison-of-markers-predicting-litter-size-in-different-pig-breeds
#2
W-S Kwon, M S Rahman, D-Y Ryu, A Khatun, M-G Pang
To overcome the limitations of conventional analysis of male fertility in animals and humans, proteomic studies have been performed to develop fertility-related biomarkers for prognosis and diagnosis of male fertility. However, the studies were focused on specific species or breeds. Therefore, a study is required to validate whether fertility-related markers would apply to other breeds in pigs. In this study, previously developed fertility-related biomarkers from Landrace were validated to use for prognosis of male fertility in commercially available breeds...
May 2017: Andrology
https://www.readbyqxmd.com/read/28400289/mathematical-modelling-of-liquid-transport-in-swelling-pharmaceutical-immediate-release-tablets
#3
Daniel Markl, Samy Yassin, D Ian Wilson, Daniel J Goodwin, Andrew Anderson, J Axel Zeitler
Oral dosage forms are an integral part of modern health care and account for the majority of drug delivery systems. Traditionally the analysis of the dissolution behaviour of a dosage form is used as the key parameter to assess the performance of a drug product. However, understanding the mechanisms of disintegration is of critical importance to improve the quality of drug delivery systems. The disintegration performance is primarily impacted by the hydration and subsequent swelling of the powder compact. Here we compare liquid ingress and swelling data obtained using terahertz pulsed imaging (TPI) to a set of mathematical models...
April 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28362140/occurrence-of-giardia-in-swedish-red-foxes-vulpes-vulpes
#4
John J Debenham, Hanne Landuyt, Karin Troell, Kristoffer Tysnes, Lucy J Robertson
Giardia duodenalis is an intestinal protozoan capable of causing gastrointestinal disease in a range of vertebrate hosts. It is transmitted via the fecal-oral route. Understanding the epidemiology of G. duodenalis in animals is important, both for public health and for the health of the animals it infects. We investigated the occurrence of G. duodenalis in wild Swedish red foxes ( Vulpes vulpes ), with the aim of providing preliminary information on how this abundant predator might be involved in the transmission and epidemiology of G...
March 31, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28341520/in-silico-prediction-of-the-effects-of-mutations-in-the-human-triose-phosphate-isomerase-gene-towards-a-predictive-framework-for-tpi-deficiency
#5
Conor Oliver, David J Timson
Triose phosphate isomerase (TPI) deficiency is a rare, but highly debilitating, inherited metabolic disease. Almost all patients suffer severe neurological effects and the most severely affected are unlikely to live beyond early childhood. Here, we describe an in silico study into well-characterised variants which are associated with the disease alongside an investigation into 79 currently uncharacterised TPI variants which are known to occur in the human population. The majority of the disease-associated mutations affected amino acid residues close to the dimer interface or the active site...
March 21, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28340959/molecular-detection-of-clostridium-difficile-on-inert-surfaces-from-a-costa-rican-hospital-during-and-after-an-outbreak
#6
Luisa Morales, César Rodríguez, María Del Mar Gamboa-Coronado
BACKGROUND: Hospital transmission of Clostridium difficile is fostered by contamination of surfaces and medical equipment with spores highly resistant to disinfectants and regular cleaning procedures. Despite the outbreaks and fatalities that C difficile causes, its epidemiology has not been studied in hospitals from middle- and low-income countries. To tackle this knowledge gap, the detection frequency of C difficile DNA on inert surfaces of a major Costa Rican hospital during and after an outbreak was compared...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/28324945/a-comparative-study-of-pseudorandom-sequences-used-in-a-c-vep-based-bci-for-online-wheelchair-control
#7
Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady
In this study, a c-VEP based BCI system was developed to run on three distinctive pseudorandom sequences, namely the m-code, the Gold-code, and the Barker-code. The Visual Evoked Potentials (VEPs) were provoked using these codes. In the online session, subjects controlled a LEGO(®) Mindstorms(®) robot around a fixed track. Choosing the optimal code proved a significant increase in accuracy (p<;0.00001) over the average performance. No single code proved significantly more accurate than the others (p=0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28316423/comparison-and-evaluation-of-four-methods-for-extracting-dna-from-giardia-duodenalis-cysts-for-pcr-targeting-the-tpi-gene
#8
Akram Sepahvand, Nader Pestehchian, Hossein Ali Yousefi, Reza Pahlavan Gharehbaba
Giardia duodenalis is an intestinal flagellated protozoan and the common cause of gastrointestinal diseases in human. This parasite can be seen in two different forms in its life cycle including as cyst and trophozoite. Due to presence of resistant cyst wall, DNA extraction inhibitors along with artifact in stool specimens, this study was performed aiming to evaluate four methods for DNA extraction from G. duodenalis cysts. Seventy G. duodenalis positive stool specimens that were confirmed by light microscope were included in this study...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28285223/transcriptome-based-analysis-on-carbon-metabolism-of-haematococcus-pluvialis-mutant-under-15-co2
#9
Ke Li, Jun Cheng, Hongxiang Lu, Weijuan Yang, Junhu Zhou, Kefa Cen
To elucidate the mechanism underlying the enhanced growth rate in the Haematococcus pluvialis mutated with (60)Co-γ rays and domesticated with 15% CO2, transcriptome sequencing was conducted to clarify the carbon metabolic pathways of mutant cells. The CO2 fixation rate of mutant cells increased to 2.57gL(-1)d(-1) under 15% CO2 due to the enhanced photosynthesis, carbon fixation, glycolysis pathways. The upregulation of PetH, ATPF0A and PetJ related to photosynthetic electron transport, ATP synthase and NADPH generation promoted the photosynthesis...
February 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28284996/first-survey-of-cryptosporidium-giardia-and-enterocytozoon-in-diarrhoeic-children-from-wuhan-china
#10
Tao Wang, Yingying Fan, Anson V Koehler, Guangxu Ma, Tao Li, Min Hu, Robin B Gasser
Intestinal protozoan pathogens cause significant diarrhoeal diseases in children. However, to date, there has been limited genetic study of the intestinal pathogens Cryptosporidium, Giardia and Enterocytozoon in humans in China, with the exception of research in a small number of cities/provinces. In the present study, PCR-based tools were used to detect and characterise these protistan parasites from 500 children with a history of diarrhoea in Wuhan and environs, Hubei province, China. Genomic DNAs from faecal samples were screened for the particular protists by PCR utilising regions in the small subunit (SSU) of the nuclear ribosomal RNA, the 60kDa glycoprotein (gp60), the internal transcribed spacer of nuclear ribosomal DNA (ITS) and/or the triose phosphate isomerase (tpi) genes as markers...
March 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28270802/molecular-epidemiology-of-giardia-blastocystis-and-cryptosporidium-among-indigenous-children-from-the-colombian-amazon-basin
#11
Angie Sánchez, Marina Munoz, Natalia Gómez, Juan Tabares, Laura Segura, Ángela Salazar, Cristian Restrepo, Miguel Ruíz, Patricia Reyes, Yuchen Qian, Lihua Xiao, Myriam C López, Juan D Ramírez
The incidence and prevalence of intestinal parasites in children is most likely due to lack of natural or acquired resistance and differences in behavior and habits closely related to environmental and socioeconomic determinants. The most important protozoa that parasitize humans are Giardia, Entamoeba, Blastocystis, and Cryptosporidium. These parasites present wide intraspecific genetic diversity and subsequently classified into assemblages and subtypes. The Amazon basin is the largest in the world and is the fifth freshwater reserve on the planet...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28259766/multispectral-uv-imaging-for-determination-of-the-tablet-coating-thickness
#12
Anna Novikova, Jens M Carstensen, J Axel Zeitler, Thomas Rades, Claudia S Leopold
The applicability of off-line multispectral ultraviolet (UV) imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, two of which contained UV active tablet cores...
March 1, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28239292/assessing-the-efficacy-of-pef-treatments-for-improving-polyphenol-extraction-during-red-wine-vinifications
#13
Guillermo Saldaña, Guillermo Cebrián, María Abenoza, Cristina Sánchez-Gimeno, Ignacio Álvarez, Javier Raso
The influence of the electric field intensity and pulse width on the improvement of total polyphenol index (TPI) and colour intensity (CI) during extraction in an ethanolic solution (30%) and during fermentation-maceration has been investigated in different grape varieties: Grenache from two harvesting times, Syrah and Tempranillo. The aim of this study was to develop a procedure to establish the PEF treatment conditions that cause enough permeabilization in the skin cells of different grape varieties to obtain a significant improvement in the vinification process in terms of increment on the polyphenol content or reduction of maceration time...
February 2017: Innovative Food Science & Emerging Technologies
https://www.readbyqxmd.com/read/28226793/a-comparative-study-of-pseudorandom-sequences-used-in-a-c-vep-based-bci-for-online-wheelchair-control
#14
Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady, Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady, Jonas Isaksen, Sadasivan Puthusserypady, Ali Mohebbi
In this study, a c-VEP based BCI system was developed to run on three distinctive pseudorandom sequences, namely the m-code, the Gold-code, and the Barker-code. The Visual Evoked Potentials (VEPs) were provoked using these codes. In the online session, subjects controlled a LEGO(®) Mindstorms(®) robot around a fixed track. Choosing the optimal code proved a significant increase in accuracy (p<;0.00001) over the average performance. No single code proved significantly more accurate than the others (p=0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224194/mycoepoxydiene-suppresses-hela-cell-growth-by-inhibiting-glycolysis-and-the-pentose-phosphate-pathway
#15
Kehua Jin, Li Li, Xihuan Sun, Qingyan Xu, Siyang Song, Yuemao Shen, Xianming Deng
Upregulation of glycolysis and the pentose phosphate pathway (PPP) is a major characteristic of the metabolic reprogramming of cancer and provides cancer cells with energy and vital metabolites to support their rapid proliferation. Targeting glycolysis and the PPP has emerged as a promising antitumor therapeutic strategy. Marine natural products are attractive sources for anticancer therapeutics, as evidenced by the antitumor drug Yondelis. Mycoepoxydiene (MED) is a natural product isolated from a marine fungus that has shown promising inhibitory efficacy against HeLa cells in vitro...
February 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28222134/gis-based-landform-classification-of-bronze-age-archaeological-sites-on-crete-island
#16
Athanasios V Argyriou, Richard M Teeuw, Apostolos Sarris
Various physical attributes of the Earth's surface are factors that influence local topography and indirectly influence human behaviour in terms of habitation locations. The determination of geomorphological setting plays an important role in archaeological landscape research. Several landform types can be distinguished by characteristic geomorphic attributes that portray the landscape surrounding a settlement and influence its ability to sustain a population. Geomorphometric landform information, derived from digital elevation models (DEMs), such as the ASTER Global DEM, can provide useful insights into the processes shaping landscapes...
2017: PloS One
https://www.readbyqxmd.com/read/28187310/proteomic-analysis-of-liver-tissue-from-rainbow-trout-oncorhynchus-mykiss-under-high-rearing-density-after-administration-of-dietary-vitamin-e-and-selenium-nanoparticles
#17
Mahdi Naderi, Saeed Keyvanshokooh, Amir Parviz Salati, Alireza Ghaedi
The aim of the present study was to investigate the effects of dietary vitamin E (vit E) and selenium nanoparticles (nanoSe) on liver proteome profile of rainbow trout under high density condition. To correlate the proteome modifications with physiological aspects, growth, serum metabolites (cortisol, glucose, lactate, ALT, AST, and ALP), and liver antioxidant-related parameters (SOD, GPx, CAT, and MDA) were also examined. A total of 1275 fish (average weight of 42.6±2.3g) were stocked into 12 tanks at a density of 80kgm(-3)...
February 4, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28164522/detection-of-clostridium-difficile-in-fecal-specimens-a-comparative-evaluation-of-nucleic-acid-amplification-test-and-toxigenic-culture
#18
Shima Lotfian, Masoumeh Douraghi, Amir Aliramezani, Sedighe Ghourchian, Abdolfatah Sarrafnejad, Hojjat Zeraati
BACKGROUND: The available data regarding Clostridium difficile infections (CDIs) in developing countries are scarce. This may be related in part to the complexity of anaerobic bacterial culture and/or cytotoxicity assays of C. difficile. Here, we evaluated the diagnostic efficacy of PCR in comparison with toxigenic culture for direct detection of conserved genes as well as toxin genes of C. difficile in fecal specimens of patients with clinical symptoms of CDI. METHODS: Loose or soft feces from 171 patients suspected of having C...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28153698/insights-into-the-photo-induced-formation-of-reactive-intermediates-from-effluent-organic-matter-the-role-of-chemical-constituents
#19
Huaxi Zhou, Lushi Lian, Shuwen Yan, Weihua Song
In the present study, the formation of triplet states of organic matters ((3)OM(∗)) from effluent organic matter (EfOM) under simulated solar irradiation was investigated. EfOM was separated into hydrophobic (HPO), transphilic (TPI), and hydrophilic (HPI) components. The quantum yield coefficients (ƒTMP) of (3)OM(∗) were measured for each component and compared to those of reference natural organic matter (NOM). NaBH4 reduction was performed on the EfOM, and the effect of aromatic ketones moieties on triplet formation was also determined...
January 26, 2017: Water Research
https://www.readbyqxmd.com/read/28126554/triosephosphate-isomerase-tpi-facilitates-the-replication-of-wssv-in-exopalaemon-carinicauda
#20
Fei Liu, Shihao Li, Guangxing Liu, Fuhua Li
Triosephosphate isomerase (TPI) is a vital enzyme in the glycolytic pathway, which can catalyze the interconversion of glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP). DHAP is involved in lipid metabolism and phospholipid synthesis. In order to know the role of TPI in WSSV infection to prawn, we cloned the full length cDNA of triosephosphate isomerase gene (EcTPI) from Exopalaemon carinicauda, and its function during WSSV infection was analyzed. EcTPI transcripts were widely distributed in all tissues, but showed relatively higher expression levels in the gill and epidermis...
January 23, 2017: Developmental and Comparative Immunology
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