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https://www.readbyqxmd.com/read/29350902/hierarchically-self-assembled-supramolecular-host-guest-delivery-system-for-delivery-of-chemotherapeutics-to-drug-resistant-cancer-tumours
#1
Hongwei Cheng, Xiaoshan Fan, Xiaoyuan Wang, Enyi Ye, Xian Jun Loh, Zibiao Li, Yun-Long Wu
In this report, a new star-like copolymer -CD-g-(PNIPAAm-b-POEGA)x consisting of a -CD core, grafted with temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer tumours. The first step of the self-assembly process involves the encapsulation of chemotherapeutics through host-guest inclusion complexation between the -cyclodextrin cavity and the anti-cancer drug...
January 19, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29350498/glioma-targeted-delivery-of-a-theranostic-liposome-integrated-with-quantum-dots-superparamagnetic-iron-oxide-and-cilengitide-for-dual-imaging-guiding-cancer-surgery
#2
He-Lin Xu, Jing-Jing Yang, De-Li ZhuGe, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Meng-Qi Tong, Bi-Xin Shen, Jian Xiao, Ying-Zheng Zhao
Herein, a theranostic liposome (QSC-Lip) integrated with superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is constructed to target glioma under magnetic targeting (MT) for guiding surgical resection of glioma. Transmission electron microscopy and X-ray photoelectron spectroscopy confirm the complete coencapsulation of SPIONs and QDs in liposome. Besides, CGT is also effectively encapsulated into the liposome with an encapsulation efficiency of ∼88...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29349448/a-study-on-platinum-iv-species-containing-an-estrogen-receptor-modulator-to-reverse-tamoxifen-resistance-of-breast-cancer
#3
Weiwei Hu, Jian Zhao, Wuyang Hua, Shaohua Gou
Several dual-action Tam-Pt(iv) complexes derived from tamoxifen (Tam) and platinum(ii) drugs were designed and synthesized for targeting estrogen receptors (ERs) and DNA. These novel compounds not only exhibited potent cytotoxicity against breast cancer cells, but also reversed the tamoxifen resistance of TamR-MCF-7 cancer cells. Computational docking assays together with cellular uptake data demonstrated that the ER ligand portion of these conjugates plays a targeting role in ER-positive tumor cells and promotes the uptake of platinum via an estrogen receptor-mediated pathway...
January 19, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29348670/intradermal-delivery-of-stat3-sirna-to-treat-melanoma-via-dissolving-microneedles
#4
Jingtong Pan, Wenyi Ruan, Mengyao Qin, Yueming Long, Tao Wan, Kaiyue Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong Xu
Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article, we first fabricated safe and novel dissolving microneedles (MNs) for topical application of STAT3 siRNA to enhance the skin penetration of siRNA and used polyethylenimine (PEI, 25 kDa) as carrier to improve cellular uptake of siRNA. The results showed that MNs can effectively penetrate skin and rapidly dissolve in the skin...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348551/designable-and-dynamic-single-walled-stiff-nanotubes-assembled-from-sequence-defined-peptoids
#5
Haibao Jin, Yan-Huai Ding, Mingming Wang, Yang Song, Zhihao Liao, Christina J Newcomb, Xuepeng Wu, Xian-Qiong Tang, Zheng Li, Yuehe Lin, Feng Yan, Tengyue Jian, Peng Mu, Chun-Long Chen
Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique "rolling-up and closure of nanosheet" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29348534/anti-cancer-activities-of-allyl-isothiocyanate-and-its-conjugated-silicon-quantum-dots
#6
Peng Liu, Mehrnaz Behray, Qi Wang, Wei Wang, Zhigang Zhou, Yimin Chao, Yongping Bao
Allyl isothiocyanate (AITC), a dietary phytochemical in some cruciferous vegetables, exhibits promising anticancer activities in many cancer models. However, previous data showed AITC to have a biphasic effect on cell viability, DNA damage and migration in human hepatoma HepG2 cells. Moreover, in a 3D co-culture of HUVEC with pericytes, it inhibited tube formation at high doses but promoted this at low doses, which confirmed its biphasic effect on angiogenesis. siRNA knockdown of Nrf2 and glutathione inhibition abolished the stimulation effect of AITC on cell migration and DNA damage...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348413/synthesis-of-luminescent-carbon-dots-with-ultrahigh-quantum-yield-and-inherent-folate-receptor-positive-cancer-cell-targetability
#7
Haifang Liu, Zhaohui Li, Yuanqiang Sun, Xin Geng, Yalei Hu, Hongmin Meng, Jia Ge, Lingbo Qu
Carbon dots (CDs) have a wide range of applications in chemical, physical and biomedical research fields. We are particularly interested in the use of CDs as fluorescence nanomaterials for targeted tumor cell imaging. One of the important aspects of success is to enhance the fluorescence quantum yields (QY) of CDs as well as increase their targetability to tumor cells. However, most of the reported CDs are limited by relative low QY. In the current study, for the first time, one-step synthesis of highly luminescent CDs by using folic acid (FA) as single precursor was obtained in natural water through hydrothermal method...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347846/poly-butylene-adipate-co-butylene-terephthalate-nanoparticles-prepared-by-electrospraying-technique-for-docetaxel-delivery-in-ovarian-cancer-induced-mice
#8
Jaleh Varshosaz, Erfaneh Ghassami, Abdollah Noorbakhsh, Ali Jahanian-Najafabadi, Mohsen Minaiyan, Ramezan Behzadi
OBJECTIVES: Ovarian cancer is still a major cause of morbidity and mortality. Docetaxel (DTX) is one of the most notable cytotoxic agents for treatment of ovarian cancer. However, its side-effects proposed considerable problems to the patients. SIGNIFICANCE: Polymeric nanoparticles (NPs) of poly (butylene adipate-co-butylene terephthalate) (Ecoflex®), a biodegradable and biocompatible polymer, were prepared for the first time by the upgradeable electrospraying technique...
January 18, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29346774/mannose-receptor-1-restricts-hiv-particle-release-from-infected-macrophages
#9
Sayaka Sukegawa, Eri Miyagi, Fadila Bouamr, Helena Farkašová, Klaus Strebel
Human mannose receptor 1 (hMRC1) is expressed on the surface of most tissue macrophages, dendritic cells, and select lymphatic or liver endothelial cells. HMRC1 contributes to the binding of HIV-1 to monocyte-derived macrophages (MDMs) and is involved in the endocytic uptake of HIV-1 into these cells. Here, we identify hMRC1 as an antiviral factor that inhibits virus release through a bone marrow stromal antigen 2 (BST-2)-like mechanism. Virions produced in the presence of hMRC1 accumulated in clusters at the cell surface but were fully infectious...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346731/direct-polymerization-of-the-arsenic-drug-penao-to-obtain-nanoparticles-with-high-thiol-reactivity-and-anti-cancer-efficiency
#10
Janina-Miriam Noy, Hongxu Lu, Philip Hogg, Jia-Lin Yang, Martina H Stenzel
PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid), which is a mitochondria inhibitor that reacts with adenine nucleotide translocator (ANT), is currently being trialed in patients with solid tumors. To increase the stability of the drug, the formation of nanoparticles has been proposed. Herein, the direct synthesis of polymeric micelles based on the anti-cancer drug PENAO is presented. PENAO is readily available for amidation reaction to form PENAO MA (4-(N-(S-penicillaminylacetyl) amino) phenylarsonous acid methacrylamide) which undergoes RAFT (reversible addition fragmentation chin transfer) polymerization with poly(polyethylene glycol methyl ether methacrylate) (PEGMA) as comonomer and poly(methylmethacrylate) (pMMA) as chain transfer agent, resulting in p(MMA)-b-p(PEG-co-PENAO) block copolymers with 3-15 wt...
January 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29346397/dose-enhancement-effects-of-gold-nanoparticles-specifically-targeting-rna-in-breast-cancer-cells
#11
Georg Hildenbrand, Philipp Metzler, Götz Pilarczyk, Vladimir Bobu, Wilhelm Kriz, Hiltraud Hosser, Jens Fleckenstein, Matthias Krufczik, Felix Bestvater, Frederik Wenz, Michael Hausmann
Localization microscopy has shown to be capable of systematic investigations on the arrangement and counting of cellular uptake of gold nanoparticles (GNP) with nanometer resolution. In this article, we show that the application of specially modified RNA targeting gold nanoparticles ("SmartFlares") can result in ring like shaped GNP arrangements around the cell nucleus. Transmission electron microscopy revealed GNP accumulation in vicinity to the intracellular membrane structures including them of the endoplasmatic reticulum...
2018: PloS One
https://www.readbyqxmd.com/read/29345909/a-metabolomics-study-reveals-enhanced-inhibition-and-metabolic-dysregulation-in-e-coli-induced-by-lactobacillus-acidophilus-fermented-black-tea-extract
#12
Kundi Yang, Mattew Duley, Jiangjiang Zhu
This study examined the ability of Lactobacillus acidophilus (LA) to ferment black tea extract (BTE), and the enhancement of Escherichia coli cellular uptake of phenolic compounds when this bacteria was incubated with fermented BTE. The inhibitory effects of BTE to E. coli bacteria, with and w/o fermentation, were compared. Several intracellular phenolic compounds, as well as metabolic profiles of E. coli with and w/o treatments, were also determined using a HPLC-MS/MS-based approach. Our results showed that out of three concentrations from the non-fermented BTE treatment, only the extract from the 25 mg/ml tea leaves solution could inhibit E...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29345051/mir-595-suppresses-the-cellular-uptake-and-cytotoxic-effects-of-methotrexate-by-targeting-slc19a1-in-cem-c1-cells
#13
Shu-Mei Wang, Lu-Lu Sun, Wan-Shui Wu, Dan Yan
The human solute carrier family 19 member 1 (SLC19A1) is the gene coding for reduced folate carrier 1 (RFC1). In our previous work, we showed that the miR-595-related polymorphism, rs1051296 G>T, which was located in the 3'-untranslated region (3'-UTR) of SLC19A1, was associated with high methotrexate (MTX) plasma concentrations in pediatric acute lymphoblastic leukaemia (ALL) patients. The present study aimed to investigate the role of miR-595 in the regulation of SLC19A1 expression and its effects on the cellular uptake and cytotoxicity of MTX in ALL CEM/C1 cells...
January 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29344592/ph-responsible-fluorescent-carbon-nanoparticles-for-tumor-selective-theranostics-via-ph-turn-on-off-fluorescence-and-photothermal-effect-in-vivo-and-in-vitro
#14
Eun Bi Kang, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Insik In, Ji Hoon Jeong, Sung Young Park
We developed nanoparticles comprising a photothermal dye (IR825)-loaded carbonized zwitterionic polymer [FNP-I] as "switch-on" pH-responsive fluorescence probes to sense intracellular cancer cells and for near-infrared (NIR) controllable photothermal therapy (PTT) in vivo and in vitro. The fluorescent "off" of FNP-I was activated after reaching the cancer cell environment, where the zwitterionic compartment of FNP lost its hydrophobicity to induce PTT-mediated heat release of IR825 under NIR irradiation in the tumor...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29341915/influence-of-ligands-property-and-particle-size-of-gold-nanoparticles-on-the-protein-adsorption-and-corresponding-targeting-ability
#15
Wei Xiao, Jingyuan Xiong, Shuang Zhang, Yang Xiong, Huajin Zhang, Huile Gao
Nanoparticulated vesicles were widely used for carriers of drugs and imaging probes. To improve the targeting delivery efficiency of these vesicles, ligands were often functionalized onto their surfaces. However, the interaction between vesicles and plasma proteins may cover the ligands and hinder the targeting delivery. It is important to address the potential influence of ligands modification on plasma protein adsorption and the following targeting delivery. In this study, two common used ligands were chosen as the model: transferrin and RGD peptide...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341617/enhancing-docetaxel-delivery-to-multidrug-resistant-cancer-cells-with-albumin-coated-nanocrystals
#16
Sheryhan F Gad, Joonyoung Park, Ji Eun Park, Gihan N Fetih, Sozan S Tous, Wooin Lee, Yoon Yeo
Intravenous delivery of poorly water-soluble anticancer drugs such as docetaxel (DTX) is challenging due to the low bioavailability and the toxicity related to solubilizing excipients. Colloidal nanoparticles are used as alternative carriers, but low drug loading capacity and circulation instability limit their clinical translation. To address these challenges, DTX nanocrystals (NCs) were prepared using Pluronic F127 as an intermediate stabilizer and albumin as a functional surface modifier, which were previously found to be effective in producing small and stable NCs...
January 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29341369/structural-factors-affecting-binding-of-platinum-anticancer-agents-with-phospholipids-influence-of-charge-and-phosphate-clamp-formation
#17
Anil Kumar Gorle, Junyong Zhang, Qin Liu, Susan J Berners-Price, Nicholas P Farrell
We report a detailed NMR and DFT study of the interaction of polynuclear platinum anticancer agents (PPCs) with negatively charged phospholipids as a mechanism for their cellular uptake. The reactions of fully 15N-labelled [{trans-PtCl(NH3)2}2(-trans-Pt(NH3)2{NH2(CH2)6NH2}2)]4+ (15N-1, 1,0,1/t,t,t) and the dinuclear [{trans-PtCl(NH3)2}2{-H2N(CH2)6NH2}]2+ (15N-2, 1,1/t,t) with the sodium salt of 1,2-dihexanoyl-sn-glycero-3-phosphate (DHPA) were studied at 298 K, pH ~5.4, by [1H,15N] HSQC 2D NMR spectroscopy...
January 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29340604/transient-recruitment-of-m-ras-gtpase-to-phagocytic-cups-in-raw264-macrophages-during-fc%C3%AE-r-mediated-phagocytosis
#18
Youhei Egami, Nobukazu Araki
M-Ras, a member of the Ras superfamily, is known to be involved in diverse cellular processes. However, its involvement in FcγR-mediated phagocytosis remains unknown. We examined the spatiotemporal localization of M-Ras during the engulfment of IgG-opsonized erythrocytes (IgG-Es) in RAW264 macrophages. By the live-cell imaging of fluorescent protein-fused M-Ras, we found that M-Ras was localized to the membrane of phagocytic cups during the early stage of phagosome formation. Notably, ratiometric image analysis revealed that M-Ras was concentrated in the membrane of forming phagosomes...
January 11, 2018: Microscopy
https://www.readbyqxmd.com/read/29340218/synthesis-and-characterization-of-hybrid-core-shell-fe3o4-sio2-nanoparticles-for-biomedical-applications
#19
I V Zelepukin, V O Shipunova, A B Mirkasymov, P I Nikitin, M P Nikitin, S M Deyev
The creation of markers that provide both visual and quantitative information is of considerable importance for the mapping of tissue macrophages and other cells. We synthesized magnetic and magneto-fluorescent nanomarkers for the labeling of cells which can be detected with high sensitivity by the magnetic particle quantification (MPQ) technique. For stabilization under physiological conditions, the markers were coated with a dense silica shell. In this case, the size and zeta-potential of nanoparticles were controlled by a modified Stober reaction...
October 2017: Acta Naturae
https://www.readbyqxmd.com/read/29340056/temozolomide-encapsulated-and-folic-acid-decorated-chitosan-nanoparticles-for-lung-tumor-targeting-improving-therapeutic-efficacy-both-in-vitro-and-in-vivo
#20
Kaidi Li, Naixin Liang, Huaxia Yang, Hongsheng Liu, Shanqing Li
Folic acid-conjugated temozolomide (TMZ)-loaded chitosan nanoparticles (CS-TMZ-FLA-NP) were developed to target lung cancer in the anticipation that folic acid would increase the affinity of nanoparticles for cancer cells. CS-TMZ-FLA-NP showed the highest anti-proliferative effect on the lung cancer cells in comparison to free TMZ and CS-TMZ-NP (nanoparticles without folic acid). A cellular uptake assay was performed on two different cell lines, L132 and A549. Cellular uptake efficiencies of CS-TMZ-NP and CS-TMZ-FLA-NP were found to be concentration-dependent in both cell lines...
December 19, 2017: Oncotarget
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