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https://www.readbyqxmd.com/read/29321423/constrictive-pericarditis-as-a-long-term-undetermined-etiology-of-ascites-and-edema
#1
Takahiro Kamio, Eiji Hiraoka, Kotaro Obunai, Hiroyuki Watanabe
Constrictive pericarditis (CP) is defined as impedance to diastolic filling caused by a fibrotic pericardium. The diagnosis of CP is a clinical challenge and requires a high index of clinical suspicion. The signs and symptoms of CP include fatigue, edema, ascites, and liver dysfunction. These can be mistakenly diagnosed as primary liver disease. We present the case of a 69-year-old woman with a 7-year history of leg edema and a 2-year history of ascites who was initially diagnosed with cryptogenic liver cirrhosis and was finally diagnosed with CP...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29247726/cryptogenic-vs-nash-cirrhosis-the-rose-exists-well-before-its-name
#2
EDITORIAL
Stephen Caldwell, Giulio Marchesini
No abstract text is available yet for this article.
December 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29240010/well-preserved-renal-function-in-children-with-untreated-chronic-liver-disease
#3
Ulla B Berg, Antal Németh
OBJECTIVES: Based on studies with hepatorenal syndrome, it is widely regarded that renal function is impacted in chronic liver disease. Therefore we investigated renal function in our children with chronic liver disease. METHODS: In a retrospective study of 277 children with chronic liver disease, renal function was investigated as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), measured as clearance of inulin and para-amino hippuric acid or clearance of iohexol...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29234937/-lysosomal-acid-lipase-deficiency-lal-d-diagnostic-and-therapeutic-options-in-an-underdiagnosed-disease
#4
REVIEW
S Synoracki, S Kathemann, K W Schmid, H Jastrow, H A Baba
BACKGROUND AND CLINICAL SETTING: Lysosomal acid lipase deficiency is an autosomal recessive storage disease caused by mutations in the LIPA gene. The accumulation of cholesteryl esters and triglycerides in hepatocytes lead to hepatomegaly with progressive fibrosis and liver cirrhosis. Characteristically, patients have a hepatomegaly combined with high serum levels of cholesterol, LDL-cholesterol and in some cases triglyceride, whereas HDL-cholesterol is decreased. Histologically, hepatocytes show a microvesicular steatosis with typically ballooned Kupffer cells...
December 12, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29234193/results-of-portosystemic-shunt-embolization-in-selected-patients-with-cirrhosis-and-recurrent-hepatic-encephalopathy
#5
Narendra S Choudhary, Sanjay Saran Baijal, Sanjiv Saigal, Amit Agarwal, Neeraj Saraf, Rohit Khandelwal, Vaibhav Jain, Anubhav Harish Khandelwal, Abhay Kapoor, Deepak Jain, Smurti R Misra, Rajesh Puri, Randhir Sud, Arvinder S Soin
Background: Large portosystemic shunts (PSSs) may lead to recurrent encephalopathy in patients with cirrhosis and embolization of these shunts may improve encephalopathy. Material and methods: Five patients underwent balloon-occluded retrograde transvenous obliteration (BRTO) or plug-assisted retrograde transvenous obliteration (PARTO) of a large PSS at our center in last 2 years for recurrent hepatic encephalopathy (HE) at a tertiary care center at north India...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29226098/occult-hcv-infection-oci-diagnosis-in-cirrhotic-and-non-cirrhotic-na%C3%A3-ve-patients-by-intra-pbmc-nested-viral-rna-pcr
#6
Mohamed Darwish Ahmed Abd Alla, Saleh Ahmed Elibiary, George Y Wu, Mostafa Kamel El-Awady
Background and Aims: Occult HCV infections (OCIs) include IgG antibody seronegative cryptogenic (COCIs), as well as seropositive secondary naïve (SNOCIs) and experienced (SEOCIs) cases. We used peripheral-blood-mononuclear-cell (PBMC)-PCR to evaluate COCIs and SNOCIs prevalence, serum HCV spontaneous disappearance (SCSD) in naïve cirrhotics and non-cirrhotics, intra-PBMC HCV-RNA strands in relation to cirrhosis density in naïve non-viremia cases, and HCV-RNA seroconversion after 1 year of solitary naïve intra-PBMC infection...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29215462/liver-transplantation-in-cryptogenic-cirrhosis-outcome-comparisons-between-nash-alcoholic-and-aih-cirrhosis
#7
Paul Joseph Thuluvath, Steven Hanish, Yulia Savva
BACKGROUND: The outcomes of liver transplantation (LT) in patients with cryptogenic cirrhosis (CC) have not been adequately examined except for small case series. We believe that patients currently listed as CC have truly cryptogenic liver disease and may have different post-LT outcomes compared to nonalcoholic steatohepatitis (NASH). METHODS: We compared the post-LT outcomes of adults with CC (n=3241) and compared them with cirrhosis from NASH (n=4089), alcohol (AC, n=7837) and autoimmune hepatitis (AIH, n=1435) using the UNOS database from 2002-16...
December 5, 2017: Transplantation
https://www.readbyqxmd.com/read/29198691/successful-liver-transplantation-from-a-donor-with-a-continuous-flow-left-ventricular-assist-device-for-9-months
#8
K Munawar, N Rajagopalan, A Grigorian, D Dennis, M Guglin
Organ donor criteria continue to be extended in an attempt to meet growing demands. Patients with continuous-flow left ventricular assist devices are one group of potential donors being considered. One concern with this group is the effect of continuous flow for a prolonged duration, as opposed to normal pulsatile flow, on end-organ function. We report the 1st case of a liver transplantation from a donor who had a continuous-flow left ventricular assist device for 9 months. The recipient was a 69-year-old woman with a history of cryptogenic cirrhosis and hepatocellular carcinoma...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29185228/deceased-donor-liver-transplant-experience-from-a-public-sector-hospital-in-india
#9
Viniyendra Pamecha, Deeplaxmi Purushottam Borle, Senthil Kumar, Kishore Gurumoorthy Subramanya Bharathy, Piyush Kumar Sinha, Shridhar Vasantrao Sasturkar, Vibuti Sharma, Chandra Kant Pandey, Shiv Kumar Sarin
BACKGROUND: Deceased donor liver transplant (DDLT) is an uncommon procedure in India. We present our experience of DDLT from a public sector teaching hospital. METHODS: A retrospective analysis of all DDLT was performed from April 2012 till September 2016. Demographics, intraoperative, donor factors, morbidity, and outcome were analyzed. RESULTS: During the study period, 305 liver transplants were performed, of which 36 were DDLT (adult 32, pediatric 4; 35 grafts; 1 split)...
November 29, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29162389/is-cryptogenic-cirrhosis-different-from-nash-cirrhosis
#10
Paul J Thuluvath, Sergey Kantsevoy, Avesh J Thuluvath, Yulia Savva
BACKGROUND & AIMS: We hypothesized that patients currently diagnosed as CC have truly 'cryptogenic' liver disease, and unlikely to have evolved from NASH. METHODS: To investigate this, we compared the clinical characteristics of adults with CC (n=7,999) with NASH (n=11,302), alcohol (AC, n=21,714) and autoimmune hepatitis (AIH, n=3,447) using the UNOS database from 2002-16. We performed an age, gender and year of listing matched comparison of CC and NASH (n= 7,201 in each group), and also stratified by the presence of obesity or diabetes mellitus (DM)...
November 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29093978/should-serum-protein-electrophoresis-be-a-surrogate-for-liver-biopsy-in-some-cases-of-alpha1-antitrypsin-deficiency
#11
Newton Key Hokama, Marcelo Padovani de Toledo Moraes, Paula de Oliveira Montandon Hokama, Fernando Gomes Romeiro
Most patients with alpha1 antitrypsin deficiency do not receive this diagnosis until developing severe complications, in particular when respiratory symptoms are absent. This is a reason for making alpha1 antitrypsin deficiency a possible diagnosis among patients with cryptogenic cirrhosis or other conditions of liver disease without a clear etiology. In this report, a case of cryptogenic cirrhosis is presented, showing the role of serum protein electrophoresis in the diagnosis, which was made before liver biopsy...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29089708/recurrent-hepatocellular-carcinoma-in-the-right-adrenal-gland-11%C3%A2-years-after-liver-transplantation-for-hepatocellular-carcinoma-a-case-report-and-literature-review
#12
REVIEW
Ismail Cem Sormaz, Gülçin Yegen, Filiz Akyuz, Fatih Tunca, Yasemin Giles Şenyürek
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, and extrahepatic metastases are typically found during disease progression. The incidence of adrenal metastasis (AM) from HCC in autopsy series ranges from 4.6 to 12.5%, and it is the second most common site of metastasis after the lungs. To date, there have been few reports of patients who underwent adrenalectomy for isolated AM from HCC after liver transplantation (LT). A woman aged 55 years was referred to our clinic for the evaluation of a right adrenal mass that was detected by abdominal ultrasonography at another center...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29055934/cryptogenic-cirrhosis-and-sitosterolemia-a-treatable-disease-if-identified-but-fatal-if-missed
#13
Fateh Bazerbachi, Erin E Conboy, Taofic Mounajjed, Kymberly D Watt, Dusica Babovic-Vuksanovic, Shailendra B Patel, Patrick S Kamath
Sitosterolemia is an autosomal recessive metabolic disease caused by mutations in ABCG5 or ABCG8 genes which encode for the (ATP)-binding cassette (ABC) transporters that are responsible for the trafficking of xenosterols. Liver involvement is not a recognized manifestation of this disease, and cirrhosis has been reported only once in the medical literature. We describe a fatal case of a 21-year old South Asian male who presented with decompensated cirrhosis, and biochemical abnormalities consistent with sitosterolemia...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29050462/a-growing-hepatic-mass-in-a-cryptogenic-cirrhosis-patient
#14
Ji Soo Song, Hee Chul Yu, Woo Sung Moon
No abstract text is available yet for this article.
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29045023/more-advanced-disease-and-worse-survival-in-cryptogenic-compared-to-viral-hepatocellular-carcinoma
#15
Tomi W Jun, Ming-Lun Yeh, Ju Dong Yang, Vincent L Chen, Pauline Nguyen, Nasra H Giama, Chung-Feng Huang, Ann W Hsing, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Lewis R Roberts, Ming-Lung Yu, Mindie H Nguyen
BACKGROUND & AIMS: Although hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major risk factors for hepatocellular carcinoma (HCC), non-viral causes of HCC, particularly non-alcoholic fatty liver disease, are becoming increasingly prevalent. The aim of this study was to compare the clinical characteristics and survival of cryptogenic and viral HCC. METHODS: We conducted a retrospective cohort study involving 3,878 consecutive HCC patients seen at two tertiary centers in the United States and one in Taiwan from 2004-2014...
October 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28987478/clinical-impact-of-intrapulmonary-vascular-dilatation-in-liver-transplant-candidates
#16
Hilary M DuBrock, Michael J Krowka, Kimberly A Forde, Karen Krok, Mamta Patel, Tiffany Sharkoski, Michael Sprys, Grace Lin, Jae K Oh, Carl D Mottram, Paul D Scanlon, Michael B Fallon, Steven M Kawut
BACKGROUND: Intrapulmonary vascular dilatations (IPVD) are frequently detected in patients with liver disease by the delayed appearance of microbubbles on contrast-enhanced echocardiography. IPVD with an elevated alveolar-arterial (A-a) gradient define hepatopulmonary syndrome, however the importance of IPVD in the absence of abnormal gas exchange is unknown. We aimed to determine the clinical impact of IPVD in patients with liver disease. METHODS: We performed a cross-sectional study within the Pulmonary Vascular Complications of Liver Disease (PVCLD2) Study, a multicenter prospective cohort study of patients being evaluated for liver transplantation...
October 5, 2017: Chest
https://www.readbyqxmd.com/read/28925475/percutaneous-implant-of-denver-peritoneo-venous-shunt-for-treatment-of-refractory-ascites-a-single-center-retrospective-study
#17
M Piccirillo, L Rinaldi, M Leongito, A Amore, A Crispo, V Granata, P Aprea, F Izzo
OBJECTIVE: Refractory ascites is defined as a lack of response to high doses of diuretics or the development of diuretic related side effects, which compel the patient to discontinue the diuretic treatment. Current therapeutic strategies include repeated large-volume paracentesis and transjugular intrahepatic portosystemic shunts (TIPS). Peritoneovenous shunt (Denver shunt) should be considered for patients with refractory ascites who are not candidates for paracentesis or TIPS. This study presents our case series in the implant of Denver peritoneovenous shunt...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28923654/case-report-of-extensive-isolated-spontaneous-celiac-trunk-dissection-after-liver-transplantation
#18
K Iwaki, S Yagi, T Iida, E Ogawa, Y Masano, T Tajima, S Okumura, G Yamamoto, N Kamo, K Taura, T Kaido, S Uemoto
Arterial dissection is a rare complication after liver transplantation (LT). We report a case of extensive isolated spontaneous celiac trunk dissection (ISCTD) up to the proper hepatic artery, left gastric artery, and splenic artery after living donor liver transplantation. A 48-year-old woman with cryptogenic liver cirrhosis underwent living donor liver transplantation. Intraoperative and postoperative Doppler ultrasound revealed sufficient flow in the hepatic artery, portal vein, and hepatic vein. On postoperative day (POD) 10, Doppler ultrasound showed reduction of hepatic arterial flow...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923628/role-of-coronary-angiography-in-pre-liver-transplantation-cardiac-evaluation-experience-from-an-asian-transplant-institution
#19
N Q Pang, W C A Kow, J H Law, L T T Pan, B L K Lim, C C R Wong, K Y S Chang, I S Ganpathi, K Madhavan
BACKGROUND: Liver transplant (LT) patients with significant coronary artery disease (CAD) have poorer outcomes. Pre-LT coronary angiography (CA) is associated with significant complications in cirrhotic patients. METHODS: This study aimed to identify predictors of abnormal CA in pre-LT cardiac assessment and to develop a predictive model to reduce unnecessary CA. From January 2006 to June 2013, 122 patients underwent CA based on the current institutional protocol...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28906453/vitamin-d-supplementation-and-non-alcoholic-fatty-liver-disease-present-and-future
#20
REVIEW
Ilaria Barchetta, Flavia Agata Cimini, Maria Gisella Cavallo
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic disease throughout the Western world and is recognized as the main cause of cryptogenic cirrhosis; however, the identification of an effective therapy for NAFLD is still a major challenge. Vitamin D deficiency is a wide-spread condition which reaches epidemic proportions in industrialized countries, mainly in relation to current lifestyle and limited dietary sources. Epidemiological studies point towards an association between hypovitaminosis D and the presence of NAFLD and steatohepatitis (NASH), independently of confounders such as obesity and insulin resistance...
September 14, 2017: Nutrients
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