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https://www.readbyqxmd.com/read/28029021/bile-acid-nuclear-receptor-farnesoid-x-receptor-therapeutic-target-for-nonalcoholic-fatty-liver-disease
#1
REVIEW
Sun Gi Kim, Byung Kwon Kim, Kyumin Kim, Sungsoon Fang
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver disorder in advanced countries. NAFLD is a spectrum of pathology involving hepatic steatosis with/without inflammation and nonalcoholic steatohepatitis with accumulation of hepatocyte damage and hepatic fibrosis. Recent studies have revealed that NAFLD results in the progression of cryptogenic cirrhosis that leads to hepatocarcinoma and cardiovascular diseases such as heart failure...
December 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28006764/telomere-dysfunction-in-nonalcoholic-fatty-liver-disease-and-cryptogenic-cirrhosis
#2
Ido Laish, Batya Mannasse-Green, Ruth Hadary, Tal Biron-Shental, Fred M Konikoff, Aliza Amiel, Yona Kitay-Cohen
Nonalcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis (CC) are considered preneoplastic conditions that might progress to hepatocellular carcinoma. We evaluated parameters of telomere dysfunction in these patient groups to study the correlation between telomere length and the progression of NAFLD. We analyzed peripheral lymphocytes from 22 patients with NAFLD, 20 patients with CC, and 20 healthy, age-matched controls. Telomere length was analyzed using quantitative fluorescence in situ hybridization, and cellular senescence was evaluated by the percentage of cells with senescence-associated heterochromatin foci...
December 23, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27959847/-pulmonary-embolism-after-endoscopic-injection-with-n-butyl-2-cyanoacrylate-for-gastric-varices
#3
Gabriela Robaina, Ricardo Albertini, Martín Carranza, Pablo Herrena Najum
Gastric varices occur in one-third of patients with portal hypertension. Bleeding from gastric varices remains a significant cause of death. Currently the first-line of treatment for gastric varices is endoscopic obliteration with N-butyl-2-cyanoacrylate. Though relatively safe, this option has several well-known complications. We report the case of a 61-year-old male patient with cryptogenic cirrhosis, who presented with fever, tachycardia and hypoxemia after endoscopic obliteration with N-butyl-2-cyanoacrylate...
2016: Medicina
https://www.readbyqxmd.com/read/27922486/the-post-transplant-course-of-patients-undergoing-liver-transplantation-for-nonalcoholic-steatohepatitis-versus-cryptogenic-cirrhosis-a-retrospective-case-control-study
#4
Lukas W Unger, Merima Herac, Katharina Staufer, Andreas Salat, Gerd Silberhumer, Michael Hofmann, Michael Trauner, Susanne Rasoul-Rockenschaub, Thomas Soliman, Thomas Reiberger, Gabriela A Berlakovich
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) can be considered the hepatic manifestation of the metabolic syndrome with nonalcoholic steatohepatitis (NASH) as its progressive form. With increasing prevalence of the metabolic syndrome, NASH cirrhosis is becoming a leading cause for liver transplantation. Some cases of orthotopic liver transplantation (OLT) due to cryptogenic cirrhosis (CC) might show typical features of NASH cirrhosis. Therefore, our aim was to assess recurrence of liver fibrosis in patients transplanted for NASH versus CC after OLT...
December 2, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27872411/osteoporosis-in-pediatric-liver-transplantation
#5
Walid Faraj, Ghina El Nounou, Abdallah Abou Al Naaj, Nancy Nakhoul, Ali Haydar, Mohammad Khalife
Liver transplantation provides an important, often life-saving treatment for end-stage liver disease. Osteoporosis post-liver transplantation has been described in adults; however, this has not been described in the pediatric population to date. We present a case of a 13-year-old female patient who underwent an orthotopic liver transplant for cryptogenic liver cirrhosis. Her immunosuppressants were tacrolimus and prednisone. Four months posttransplant, she started complaining of bilateral lower limb pain and limping while walking, progressing to a point where she was almost immobile...
December 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27822261/the-cause-and-effect-relationship-between-type-2-diabetes-mellitus-and-clinically-overt-cryptogenic-cirrhosis-a-matter-that-must-be-seriously-revised
#6
Abbas Tavakolian Arjmand, Nasrin Razavianzadeh
No abstract text is available yet for this article.
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27818588/update-on-occult-hepatitis-b-virus-infection
#7
REVIEW
Manoochehr Makvandi
The event of mutations in the surface antigen gene of hepatitis B virus (HBV) results in undetectable hepatitis B surface antigen with positive/negative anti-hepatitis B core (anti-HBc) antibody status in serum and this phenomenon is named occult hepatitis B infection (OBI). The presence of anti-HBc antibody in serum is an important key for OBI tracking, although about 20% of OBI cases are negative for anti-HBc antibody. The diagnosis of OBI is mainly based on polymerase chain reaction (PCR) and real-time PCR assays...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27805526/histologic-changes-in-bone-marrow-biopsies-from-liver-transplant-patients
#8
Pelin Börcek, Binnaz Handan Özdemir, Çiğdem Sercan, Eda Yılmaz Akçay, Sema Karakuş, Mehmet Haberal
OBJECTIVES: Liver transplant may complicated by various hematologic conditions, resulting in indication for bone marrow biopsy. Immunosuppressive therapies, specific infections, and secondary neoplasms affect bone marrow. In the present study, we evaluated the histologic spectrum of bone marrow findings in liver allograft recipients. MATERIALS AND METHODS: Of 338 patients who received liver transplants and were followed at the Başkent University, Faculty of Medicine, 44 patients underwent bone marrow biopsy...
2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27621523/ayurvedic-management-of-cirrhotic-ascites
#9
G Aswathy, Prasanth Dharmarajan, Ananth Ram Sharma, V K Sasikumar, M R Vasudevan Nampoothiri
Cirrhosis is the final stage of most of the chronic liver diseases and is most invariably complicated by portal hypertension resulting in ascites. A case of chronic liver disease with portal hypertension (cryptogenic cirrhosis), managed at Amrita School of Ayurveda is discussed in this paper. The clinical picture was that of an uncomplicated cirrhotic ascites. Snehapāna (therapeutic oral administration of lipids) followed by virecana (purgation) was done after an initial course of nityavirecana (daily purgation)...
April 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/27555800/idiopathic-noncirrhotic-portal-hypertension-current-perspectives
#10
REVIEW
Oliviero Riggio, Stefania Gioia, Ilaria Pentassuglio, Valeria Nicoletti, Michele Valente, Giulia d'Amati
The term idiopathic noncirrhotic portal hypertension (INCPH) has been recently proposed to replace terms, such as hepatoportal sclerosis, idiopathic portal hypertension, incomplete septal cirrhosis, and nodular regenerative hyperplasia, used to describe patients with a hepatic presinusoidal cause of portal hypertension of unknown etiology, characterized by features of portal hypertension (esophageal varices, nonmalignant ascites, porto-venous collaterals), splenomegaly, patent portal, and hepatic veins and no clinical and histological signs of cirrhosis...
2016: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/27555069/osteoporosis-in-pediatric-liver-transplantation
#11
Walid Faraj, Ghina El Nounou, Abdallah Abou Al Naaj, Nancy Nakhoul, Ali Haydar, Mohammad Khalife
Liver transplantation provides an important, often life-saving treatment for end-stage liver disease. Osteoporosis post-liver transplantation has been described in adults; however, this has not been described in the pediatric population to date. We present a case of a 13-year-old female patient who underwent an orthotopic liver transplant for cryptogenic liver cirrhosis. Her immunosuppressants were tacrolimus and prednisone. Four months posttransplant, she started complaining of bilateral lower limb pain and limping while walking, progressing to a point where she was almost immobile...
August 22, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27520584/aneuploidy-and-asynchronous-replication-in-non-alcholic-fatty-liver-disease-and-cryptogenic-cirrhosis
#12
Ido Laish, Batya Mannasse-Green, Ruth Hadary, Fred M Konikoff, Aliza Amiel, Yona Kitay-Cohen
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis (CC), which is largely a late sequela of NAFLD, are considered pre-neoplastic conditions that might progress to hepatocellular carcinoma. Aneuploidy, telomere aggregates and synchronization of replication were evaluated as markers of genetic instability in these patients. METHODOLOGY: Peripheral blood lymphocytes from 22 patients with NAFLD, 20 patients with CC and 20 age-matched healthy controls were analyzed...
November 15, 2016: Gene
https://www.readbyqxmd.com/read/27516529/chronic-hepatitis-e-an-emerging-disease-in-an-immunocompromised-host
#13
Amitabh Singh, Rachna Seth, Anand Gupta, Shalimar, Baibaswata Nayak, Subrat Kumar Acharya, Prasenjit Das
Chronic hepatitis E virus (HEV) infection is increasingly being reported in immunosuppressed individuals with HIV, patients with haematological malignancy and transplant recipients. The diagnosis of cirrhosis and liver failure post chronic HEV is controversial due to lack of standard diagnostic criteria. The treatment benefits of ribavirin in chronic HEV of genotype 1 are not well reported. We report a case of chronic HEV infection of genotype 1 leading to chronic liver disease in a child cured of acute leukaemia...
August 10, 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/27493866/sarcopenic-obesity-and-myosteatosis-are-associated-with-higher-mortality-in-patients-with-cirrhosis
#14
Aldo J Montano-Loza, Paul Angulo, Judith Meza-Junco, Carla M M Prado, Michael B Sawyer, Crystal Beaumont, Nina Esfandiari, Mang Ma, Vickie E Baracos
BACKGROUND AND AIMS: Obesity is frequently associated with cirrhosis, and cirrhotic patients may develop simultaneous loss of skeletal muscle and gain of adipose tissue, culminating in the condition of sarcopenic obesity. Additionally, muscle depletion is characterized by both a reduction in muscle size and increased proportion of muscular fat, termed myosteatosis. In this study, we aimed to establish the frequency and clinical significance of sarcopenia, sarcopenic obesity and myosteatosis in cirrhotic patients...
May 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27486010/nafld-and-liver-transplantation-current-burden-and-expected-challenges
#15
REVIEW
Raluca Pais, A Sidney Barritt, Yvon Calmus, Olivier Scatton, Thomas Runge, Pascal Lebray, Thierry Poynard, Vlad Ratziu, Filomena Conti
Because of global epidemics of obesity and type 2 diabetes, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing both in Europe and the United States, becoming one of the most frequent causes of chronic liver disease and predictably, one of the leading causes of liver transplantation both for end-stage liver disease and hepatocellular carcinoma. For most transplant teams around the world this will raise many challenges in terms of pre- and post-transplant management. Here we review the multifaceted impact of NAFLD on liver transplantation and will discuss: (1) NAFLD as a frequent cause of cryptogenic cirrhosis, end-stage chronic liver disease, and hepatocellular carcinoma; (2) prevalence of NAFLD as an indication for liver transplantation both in Europe and the United States; (3) the impact of NAFLD on the donor pool; (4) the access of NAFLD patients to liver transplantation and their management on the waiting list in regard to metabolic, renal and vascular comorbidities; (5) the prevalence and consequences of post-transplant metabolic syndrome, recurrent and de novo NAFLD; (6) the alternative management and therapeutic options to improve the long-term outcomes with particular emphasis on the correction and control of metabolic comorbidities...
December 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27353983/paediatric-living-donor-liver-transplantation-asingle-centre-experience-from-pakistan
#16
Abu Bakar Hafeez Bhatti, Faisal Saud Dar, Syeda Shaheera Hashmi, Haseeb Zia, Munir Iqbal Malik, Najmul Hassan Shah
OBJECTIVE: To determine the outcomes of paediatric living donor liver transplantation (LDLT) recipients from Pakistan in terms of 90-day morbidity and mortality. STUDY DESIGN: Cohort study. PLACE AND DURATION OF STUDY: Shifa International Hospital, Islamabad, Pakistan, between April 2012 and April 2015. METHODOLOGY: All patients in paediatric age group (≤ 17 years) who underwent LDLT with a minimum follow-up of 3 months, were included...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27225798/prevalence-severity-and-impact-on-quality-of-life-of-restless-leg-syndrome-in-patients-with-liver-cirrhosis-in-india
#17
Amit Goel, Shankar Lal Jat, Avani Sasi, Vimal Kumar Paliwal, Rakesh Aggarwal
BACKGROUND AND AIM: Restless leg syndrome (RLS) has recently been shown to be increased in patients with liver cirrhosis (LC). We prospectively studied the prevalence and severity of RLS, and the effect of its presence on the quality of life (QoL) in Indian patients with LC. METHODS: Adult patients with stable LC (n = 121; 98 male; median age 47 [range 18-68] years; Child-Pugh class A/B/C 59/39/23), were prospectively enrolled along with a group of healthy, adult controls (n = 121; 84 male; median age 42 [19-70] years)...
May 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27219619/lysosomal-acid-lipase-activity-is-reduced-both-in-cryptogenic-cirrhosis-and-in-cirrhosis-of-known-etiology
#18
Umberto Vespasiani-Gentilucci, Paolo Gallo, Fiorella Piemonte, Elisabetta Riva, Aldostefano Porcari, Ferruccio Vorini, Giulia Tozzi, Livia Piccioni, Giovanni Galati, Antonio De Vincentis, Simone Carotti, Sergio Morini, Jessica D'Amico, Silvia Angeletti, Claudio Pedone, Antonio Picardi
Liver cirrhosis is characterized by a severe acquired reduction of LAL-activity, the precise causes and consequences of which need to be further addressed. DBS-determined lysosomal enzyme activities seem to be affected by white blood cell and platelet counts, and the specificity of these tests can be reduced when applied to determined populations, such as cirrhotics.
2016: PloS One
https://www.readbyqxmd.com/read/27194893/acute-on-chronic-liver-failure-aclf-in-coastal-eastern-india-a-single-center-experience
#19
Girish Kumar Pati, Ayaskanta Singh, Bijay Misra, Debasis Misra, Haribhakti Seba Das, Chittaranjan Panda, Shivaram Prasad Singh
BACKGROUND AND OBJECTIVES: Acute-On-Chronic liver failure (ACLF) is an emerging entity. The present study was undertaken to analyze the clinical profile and natural course of ACLF patients. PATIENTS AND METHODS: ACLF was defined as per Asia Pacific Association for the Study of Liver consensus criteria 2009. Patients fulfilling these criteria with some deviations were included and prospectively evaluated for clinical profile, etiologies of acute decompensation (AD) and underlying chronic liver disease, and short-term natural course [3 months]...
March 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27142096/recurrence-of-graft-steatosis-after-liver-transplantation-for-cryptogenic-cirrhosis-in-recently-commenced-liver-transplant-program
#20
Rohan C Siriwardana, Madunil Anuk Niriella, Anuradha Supun Dassanayake, Chandika Anuradha Habarakada Liyanage, Bhagya Gunetilleke, Hithanadura Janaka de Silva
Non-alcoholic fatty liver disease (NAFLD) seems to recur in at least one third of patients transplanted for non-alcoholic steatohepatitis (NASH)-related cirrhosis. While, NASH recurrence does not seem to affect overall graft and patient survival up to 10 years, cardiovascular and infection-related morbidity and mortality seem to be increased in these patients. This report looks at the graft histology in patients who were transplanted for NASH-related cirrhosis after short-term follow up. We report a high prevalence of recurrent NAFLD in liver grafts post-transplant among five patients...
May 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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