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https://www.readbyqxmd.com/read/29446443/association-of-killer-cell-immunoglobulin-like-receptors-with-spontaneous-clearance-of-hepatitis-c-virus-in-the-chinese-population
#1
Zhengang Shan, Jieting Huang, Qiao Liao, Ke Huang, Min Wang, Ru Xu, Xi Tang, Weiyun Zhang, Kenrad Nelson, Yongshui Fu, Chengyao Li, Xia Rong
BACKGROUND: Natural killer (NK) cells are critical components in innate immune response to viral infection. Killer cell immunoglobulin-like receptors (KIRs) are involved in regulating the balance of activation or inhibitory function of NK cells. However, the association of KIRs with the spontaneous clearance of hepatitis C virus (HCV) remains unclear in the Chinese population. STUDY DESIGN AND METHODS: A total of 407 HCV-seropositive voluntary blood donors were recruited, including 203 with spontaneous viral clearance and 204 with chronic infection...
February 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29429413/a-case-of-a-patient-infected-with-a-hepatitis-c-virus-genotype-3a-multidrug-resistant-variant-in-pakistan
#2
Asad Zia, Muhammad Ali, Hafsa Aziz, Muhammad Zia, Zabta Khan Shinwari, Abida Raza
BACKGROUND: Approximately 10 million people in Pakistan are infected with the hepatitis C virus (HCV). Most patients develop chronic hepatitis, with rare cases of spontaneous clearance. However, little is known about multidrug resistant viral variants in Pakistan. FINDINGS: This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in 2003. After an initial diagnosis of viral infection, the patient remained treatment naïve for 5 years...
February 11, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29380700/role-of-interleukin-28b-polymorphisms-in-response-to-interferon-based-therapy-for-hepatitis-c-virus-clearance
#3
Manu Asthana, Sushil Kumar Sahu, Amit Kumar, Suchitra Mohanty, Sudipta Chakrabarti, Piyanki Das, Nabanita Roy Chattopadhya, Koustav Chatterjee, Shivaram Prasad Singh, Shanmugam Rajasubramaniam, Tathagata Choudhuri
Interleukin-28B (IL28B) locus on a human chromosomal region 19q13 is responsible for immune protection against viruses. IL28B in hepatitis C virus (HCV) infection determines the fate of infection towards causing spontaneous clearance or chronic liver infection. Choice of treatment in chronic hepatitis C infection includes use of direct acting antivirals, pegylated-interferon (PEG-IFN) or ribavirin (RBV) therapy. Interferon free regimens are also suggested to be useful in drug resistant patients. Genome-wide association studies (GWAS), comprehensive meta-analysis and independent case-control studies in different ethnic populations have demonstrated association between certain Il-28B polymorphisms and its effect on the response to PEG-IFN-RBV therapy in HCV patients...
January 28, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29369421/genetic-variation-in-il28b-ifnl3-and-response-to-interferon-alpha-treatment-in-myeloproliferative-neoplasms
#4
Marie Lindgren, Jan Samuelsson, Lars Nilsson, Håvar Knutsen, Waleed Ghanima, Johan Westin, Peter L Johansson, Björn Andréasson
OBJECTIVE: In myeloproliferative neoplasms (MPN) interferon-alpha (IFN-α) is an effective treatment with disease-modifying properties but currently with no clear predictors of treatment outcome. Recent genome-wide association studies in chronic hepatitis C, have found a strong influence of genetic polymorphism near the IL28B (IFNL3) gene on response to IFN-α treatment. In this study we sought to evaluate the prognostic impact of IL28B rs12979860, rs8099917 and rs12980275 on IFN-α treatment response in myeloproliferative neoplasms...
January 25, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29354660/the-effect-of-shorter-treatment-regimens-for-hepatitis-c-on-population-health-and-under-fixed-budgets
#5
Jake R Morgan, Arthur Y Kim, Susanna Naggie, Benjamin P Linas
Background: Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and cost-effectiveness of 8 vs 12 weeks of therapy in treatment-naïve, noncirrhotic, genotype 1 HCV-infected black and nonblack individuals and considered scenarios of IL28B and NS5A resistance testing to determine treatment duration in sensitivity analyses...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29340806/distribution-of-il28b-and-il10-polymorphisms-as-genetic-predictors-of-treatment-response-in-pakistani-hcv-genotype-3-patients
#6
Humaira Naeemi, Rabia Aslam, Syed Mohsin Raza, Muhammad Aiman Shahzad, Shagufta Naz, Sobia Manzoor, Saba Khaliq
There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pathogenesis and clearance of HCV, and sustained virologic response (SVR). An interleukin 28B (IL28B) gene polymorphism has been shown to modify treatment outcomes, but the effects of interleukin 10 (IL10) polymorphisms have not been previously assessed in the Pakistani population...
January 16, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29285382/il18-rs360719-a-g-il18r1-rs13015714-g-t-il18rap-rs917997-c-t-and-il28b-rs8099917-t-g-polymorphisms-and-risk-of-gastric-cardiac-adenocarcinoma
#7
Jun Yin, Changqing Dong, Weifeng Tang, Ruiping Liu, Suocheng Chen, Liang Zheng, Haiyong Gu
The present study was conducted to investigate the association between gastric cardiac adenocarcinoma (GCA) and four functional single-nucleotide polymorphisms (SNPs), including interleukin 18 (IL18) rs360719 A>G, IL18 receptor 1 (IL18R1) rs13015714 G>T, IL18 receptor accessory protein (IL18RAP) rs917997 C>T and interleukin 28B (IL28B) rs8099917 T>G variants. A hospital-based case-control study was performed to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29284412/ccl4-is-the-only-predictor-for-non-responder-in-gt-1-chc-patients-with-favorable-il28b-genotype-when-treated-with-pegifn-rbv
#8
Chia-Chen Lin, Shih-Huan Su, Wen-Juei Jeng, Chien-Hao Huang, Wei Teng, Wei-Ting Chen, Yi-Cheng Chen, Chun-Yen Lin, I-Shyan Sheen
BACKGROUND: Chemokines/cytokines play important roles in the pathogenesis of chronic hepatitis C (CHC). However, their clinical characteristics and implications in treatment responses to pegylated interferon plus ribavirin treatment (PegIFN/RBV) have not been fully illustrated yet. In this study, we intended to investigate the possible predictability of serum chemokines/cytokines on the treatment response in Taiwanese of CHC, genotype-1 (GT-1). METHODS: 60 Patients with GT-1 CHC infection who had been treated with PegIFN/RBV were enrolled, including 27 (45%) with sustained virological response (SVR), 11 (18%) with relapse after 48 weeks of treatment and 22 (37%) non-response (NR)...
December 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29279441/data-mining-machine-learning-algorithms-using-il28b-genotype-and-biochemical-markers-best-predicted-advanced-liver-fibrosis-in-chronic-hcv
#9
Hend Ibrahim Shousha, Abubakr Hussein Awad, Dalia Abdelhamid Omran, Mayada Mohamed Elnegouly, Mahasen Mabrouk
  IL28 single nucleotide polymorphism (rs12979860) is an aetiology-independent predictor of hepatitis C virus (HCV) related hepatic fibrosis. Data mining is a method of predictive analysis which can explore tremendous volumes of information found in health records to discover hidden patterns and relationships. The study aims to evaluate and compare the prediction accuracy of APRI, FIB-4 versus data mining for prediction of HCV related advanced fibrosis. This retrospective study included 427 patients with chronic HCV...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29278743/expression-and-purification-of-biologically-active-bovine-interferon-%C3%AE-3-il28b-in-pichia-pastoris
#10
S Barathiraja, P A V Gangadhara, V Umapathi, H J Dechamma, G R Reddy
Interferon lambda-3 (IFNλ3) which is also known as IL28B is a member of type III Interferons which are structurally and genetically different from type I Interferons. These Interferons induce signal transduction pathways similar to type I Interferons which results in the activation of Interferon Stimulated Genes (ISGs). This group of Interferons are tissue specific and reported to have antiviral activity. In the present communication, we report the expression of bovine IFNλ3 gene (coding for the mature protein) in Pichia pastoris, purification of the expressed protein and evaluation of its biological activity...
December 23, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/29247709/single-nucleotide-polymorphism-rs1800872-in-the-promoter-region-of-the-il10-gene-is-associated-with-predisposition-to-chronic-hepatitis-c-in-russian-population
#11
Andrey V Barkhash, Galina V Kochneva, Elena V Chub, Aida G Romaschenko
Previously, we studied an association of two IL28B gene single nucleotide polymorphisms (SNPs) and three IL10 gene SNPs with predisposition to tick-borne encephalitis in a Russian population. In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused by structurally similar, related virus from the Flaviviridae family) was investigated in the same population. Only the IL10 promoter rs1800872 SNP was associated with predisposition to chronic hepatitis C...
December 13, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29210660/host-factors-predictors-in-long-term-nonprogressors-hiv-1-infected-with-distinct-viral-clades
#12
J S Santos, S M Almeida, G F Silveira, J Bordignon, S Lm Teixeira, Acm Lima, S M Raboni
BACKGROUND: HIV-1+ long-term non-progressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS: We evaluated the plasma levels of IP-10/IL-8 chemokines, HLA-B alleles, and IL28B rs12979860 polymorphism in 24 LTNPs who presented with infection by different clades of HIV-1. RESULTS: IL-8 chemokine was significantly higher in progressors than in LTNPs, but there was no difference between the LTNP subgroups...
December 6, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29158528/fine-mapping-of-genetic-loci-driving-spontaneous-clearance-of-hepatitis-c-virus-infection
#13
Hailiang Huang, Priya Duggal, Chloe L Thio, Rachel Latanich, James J Goedert, Alessandra Mangia, Andrea L Cox, Gregory D Kirk, Shruti Mehta, Jasneet Aneja, Laurent Alric, Sharyne M Donfield, Matthew E Cramp, Salim I Khakoo, Leslie H Tobler, Michael Busch, Graeme J Alexander, Hugo R Rosen, Brian R Edlin, Florencia P Segal, Georg M Lauer, David L Thomas, Mark J Daly, Raymond T Chung, Arthur Y Kim
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108206/-association-between-il28b-gene-polymorphisms-and-therapeutic-effect-of-individualized-pegylated-interferon-alpha-therapy-in-hbeag-positive-chronic-hepatitis-b-patients
#14
L J Huang, J E Yang, Z X Xu, G L Wang
No abstract text is available yet for this article.
October 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29080719/interleukin-28b-rs12979860-genotype-and-human-immunodeficiency-virus-type-1-susceptibility-aids-development-and-therapeutic-outcome
#15
Imane Zaidane, Lahcen Wakrim, Ahd Oulad Lahsen, Rajaa Bensghir, Hajar Chihab, Fatima Zahra Jadid, Raouia El Fihry, Hassan Lamdini, Naouar Fayssel, Kamal Marhoum El Filali, Mounia Oudghiri, Soumaya Benjelloun, Sayeh Ezzikouri
Human Immunodeficiency Virus type 1 (HIV-1) infection and progression varies widely among individuals. Interferon-λ3 exerts anti-HIV function by activating JAK/STAT pathway-mediated innate immunity. Therefore, we aimed to investigate the association between single nucleotide polymorphisms of the interleukin 28B (IL28B) gene, and the risk of acquisition, AIDS development and therapeutic outcome of HIV-1 in a Moroccan population. A total of 266 HIV-1 seropositive and 158 HIV-1 seronegative subjects were enrolled...
October 25, 2017: Human Immunology
https://www.readbyqxmd.com/read/28992878/peginterferon-alfa-2a-for-the-treatment-of-chronic-hepatitis-c-in-the-era-of-direct-acting-antivirals
#16
REVIEW
Yan Huang, Ming-Hui Li, Min Hou, Yao Xie
BACKGROUND: The availability of novel direct-acting antivirals (DAAs) represents a new era of curative hepatitis C virus (HCV) treatment, with over 95% of patients infected with HCV genotype 1 achieving sustained virological response (SVR). Nevertheless, the majority of patients globally are unable to access these treatments because of cost and infrastructure constraints and, thus, remain untreated and uncured. DATA SOURCE: Relevant articles of peginterferon (PegIFN)-based treatments in HCV and sofosbuvir-based treatments, simeprevir, daclatasvir/asunaprevir, ritonavir-boosted paritaprevir/ombitasvir/dasabuvir, and grazoprevir/elbasvir, were searched in PubMed database, including general population and special population...
October 15, 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28956375/-function-of-the-il28b-gene-in-hepatitis-b-virus-infection
#17
Chenglin Zhang, Yuzhu Song, Yumei Ma, A'mei Zhang
Hepatitis B virus (HBV) that causes Hepatitis B with a high chronic rate, could lead to hepatic cirrhosis and hepatocellular carcinoma. The IL28B gene belongs to a new interferon family λ and its genetic polymorphisms are identified to be associated with treatment effect and viral clearance. The purpose of this review is to discuss the role of the IL28B gene in treatment response and viral clearance of HBV-infected individuals, and further to reveal the mechanisms. This review could provide a theoretical basis for personalized medicines of HBV patients...
February 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28954067/profile-of-hiv-subtypes-in-hiv-hbv-and-hiv-hcv-coinfected-patients-in-southern-brazil
#18
Valéria Miranda Avanzi, Bianca Arão Vicente, Nayara Carvalho Polido Beloto, Monica Maria Gomes-da-Silva, Clea Elisa Lopes Ribeiro, Felipe Francisco Tuon, Luine Rosele Renaud Vidal, Meri Bordignon Nogueira, Sonia Mara Raboni
INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28903504/spontaneous-viral-load-decline-and-subsequent-clearance-of-chronic-hepatitis-c-virus-in-postpartum-women-correlates-with-favorable-interleukin-28b-gene-allele
#19
Mohamed Hashem, Ravi Jhaveri, Doa'a A Saleh, Sahar A Sharaf, Fatma El-Mougy, Lobna Abdelsalam, Michelle D Shardell, Hesham El-Ghazaly, Samer S El-Kamary
Background: Postpartum hepatitis C viral (HCV) load decline followed by spontaneous clearance has been previously described. Herein we identify predictors for viral decline in a cohort of HCV-infected postpartum women. Methods: Pregnant women at Cairo University were screened for anti-HCV antibodies and HCV RNA, and viremic women were tested for quantitative HCV RNA at 3, 6, 9, and 12 months postpartum. Spontaneous clearance was defined as undetectable viremia twice at least 6-months apart...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28892235/beclabuvir-in-combination-with-asunaprevir-and-daclatasvir-for-hepatitis-c-virus-genotype-1-infection-a-systematic-review-and-meta-analysis
#20
Ali Mahmoud Ahmed, Mohamed Fahmy Doheim, Omar Mohamed Mattar, Nourin Ali Sherif, Duy Hieu Truong, Pham Thi Le Hoa, Kenji Hirayama, Nguyen Tien Huy
Daclatasvir, asunaprevir, and beclabuvir are direct-acting antivirals for patients with hepatitis C virus genotype 1 infection. This systematic review and meta-analysis investigating the efficacy and safety of this three-drug combination in HCV genotype 1 infection. Eleven electronic search engines were searched for relevant publications. Studies were screened for eligibility and data was extracted. The outcomes were pooled as event rate and risk ratio. The protocol was registered in PROSPERO (CRD42017054391)...
September 11, 2017: Journal of Medical Virology
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