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https://www.readbyqxmd.com/read/29666343/interleukin-gene-polymorphisms-and-susceptibility-to-hiv-1-infection-a-meta-analysis
#1
Chrissa G Tsiara, Georgios K Nikolopoulos, Niki L Dimou, Katerina G Pantavou, Pantelis G Bagos, Benedicta Mensah, Michael Talias, Georgia G Braliou, Dimitra Paraskeva, Stefanos Bonovas, Angelos Hatzakis
Some subjects are repeatedly exposed to human immunodeficiency virus (HIV), yet they remain uninfected. This suggests the existence of host-resistance mechanisms. The current study synthesizes the evidence regarding the association between interleukin (IL) gene polymorphisms and HIV susceptibility. Medline, Scopus and the Web of Science databases were systematically searched, and a meta-analysis of case-control studies was conducted. Univariate and bivariate methods were used. The literature search identified 42 eligible studies involving 15,727 subjects...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29626271/bursal-immunopathology-responses-of-specific-pathogen-free-chickens-and-red-jungle-fowl-infected-with-very-virulent-infectious-bursal-disease-virus
#2
Mohd Isa Farhanah, Abdul Rahaman Yasmin, Nguyen Phuc Khanh, Swee Keong Yeap, Mohd Hair-Bejo, Abdul Rahman Omar
Very virulent infectious bursal disease virus (vvIBDV) targets B lymphocytes in the bursa of Fabricius (BF), causing immunosuppression and increased mortality rates in young birds. There have been few studies on the host immune response following vvIBDV infection at different inoculum doses in chickens with different genetic backgrounds. In this study, we characterized the immune responses of specific-pathogen-free (SPF) chickens and Malaysian red jungle fowl following infection with vvIBDV strain UPM0081 at 103...
April 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29605690/lack-of-evidence-of-association-between-ifng-and-il28b-polymorphisms-and-quantiferon-cmv-test-results-in-seropositive-transplant-patients
#3
Rocío Aguado, Aurora Páez-Vega, María L Agüera, Miguel Montejo, Lluis Guirado, Jesús Fortún, Alejandro Suárez-Benjumea, Oscar Len, María C Fariñas, Carmen de Gracia, Domingo Hernández, María J Cobos-Ceballos, Julián Torre-Cisneros, Sara Cantisán
The aim of this study was to analyze the relationship between the IFNG+874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant patients (108 kidney, 68 liver and 8 lung) were recruited. Of them, 151 patients were QF-CMV Reactive (IFNG ≥0.2 UI/mL) and 33 were Non-reactive. Genotype frequencies in the study population were TT (26...
March 29, 2018: Human Immunology
https://www.readbyqxmd.com/read/29599611/daclatasvir-plus-asunaprevir-in-treatment-na%C3%A3-ve-patients-with-hepatitis-c-virus-genotype-1b-infection
#4
Lai Wei, Fu-Sheng Wang, Ming-Xiang Zhang, Ji-Dong Jia, Alexey A Yakovlev, Wen Xie, Eduard Burnevich, Jun-Qi Niu, Yong Jin Jung, Xiang-Jun Jiang, Min Xu, Xin-Yue Chen, Qing Xie, Jun Li, Jin-Lin Hou, Hong Tang, Xiao-Guang Dou, Yash Gandhi, Wen-Hua Hu, Fiona McPhee, Stephanie Noviello, Michelle Treitel, Ling Mo, Jun Deng
AIM: To assess daclatasvir plus asunaprevir (DUAL) in treatment-naïve patients from mainland China, Russia and South Korea with hepatitis C virus (HCV) genotype 1b infection. METHODS: Patients were randomly assigned (3:1) to receive 24 wk of treatment with DUAL (daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period (immediate treatment arm) or following 12 wk of matching placebo (placebo-deferred treatment arm)...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29536805/the-effect-of-the-first-generation-hcv-protease-inhibitors-boceprevir-and-telaprevir-and-the-relation-to-baseline-ns3-resistance-mutations-in-genotype-1-experience-from-a-small-swedish-cohort
#5
Midori Kjellin, Terése Wesslén, Erik Löfblad, Johan Lennerstrand, Anders Lannergård
BACKGROUND: The clinical experience with protease-inhibitor (PI) triple regimen appears disappointing regarding effect, side effects, high work load, and costs. This real-world study evaluates baseline and emerging resistance-associated substitutions (RASs) and their significance for treatment outcome. METHOD: Thirty-six genotype 1a/b patients treated according to Swedish recommendations during 2011-2013 with triple therapy including pegylated interferon and ribavirin in combination with a protease-inhibitor, either boceprevir (BOC) or telaprevir (TVR), were retrospectively evaluated...
March 14, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29510558/helicobacter-pylori-serology-in-relation-to-hepatitis-c-virus-infection-and-il28b-single-nucleotide-polymorphism
#6
Alexander Gutwerk, Thomas Wex, Kerstin Stein, Cosima Langner, Ali Canbay, Peter Malfertheiner, Alexander Link
The aim of the study was to evaluate the serological rate of Helicobacter pylori ( H. pylori ) infection in patients with chronic hepatitis C virus (HCV) infection and determine any correlations with liver damage and IL28B single-nucleotide polymorphism (SNP). One hundred eighty-nine patients with chronic HCV infection were included in the study, and H. pylori status was defined based on anti- H. pylori -IgG or anti-CagA-IgG antibodies using enzyme-linked immunosorbent assay (ELISA). Liver damage was assessed using histology or transient elastography...
March 5, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29504692/efficacy-of-ledipasvir-sofosbuvir-with-or-without-ribavirin-for-12-weeks-in-genotype-1b-hcv-patients-previously-treated-with-a-nonstructural-protein-5a-inhibitor-containing-regimen
#7
Hiroki Ikeda, Tsunamasa Watanabe, Hirohito Shimizu, Tetsuya Hiraishi, Rena Kaneko, Toshiyuki Baba, Hideaki Takahashi, Kotaro Matsunaga, Nobuyuki Matsumoto, Hiroshi Yasuda, Chiaki Okuse, Shogo Iwabuchi, Michihiro Suzuki, Fumio Itoh
AIM: The therapeutic benefit of adding ribavirin (RBV) to 12 weeks of ledipasvir/sofosbuvir (LDV/SOF) for patients who experienced failure of a previous nonstructural protein (NS) 5A inhibitor-containing regimen is unclear. METHODS: A total of 29 genotype 1b HCV patients who had failed prior daclatasvir (DCV) plus asunaprevir (ASV) treatment were retreated for 12 weeks of LDV/SOF, with or without RBV. Antiviral efficacy and predictive factors associating with a sustained virological response at 24 weeks (SVR24) were evaluated retrospectively...
March 5, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29499724/il28b-gene-polymorphism-rs12979860-but-not-rs8099917-contributes-to-the-occurrence-of-chronic-hcv-infection-in-uruguayan-patients
#8
Natalia Echeverría, Daniela Chiodi, Pablo López, Adriana Sanchez Ciceron, Jenniffer Angulo, Marcelo López-Lastra, Paola Silvera, Adrian Canavesi, Carla Bianchi, Valentina Colistro, Juan Cristina, Nelia Hernandez, Pilar Moreno
BACKGROUND: Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) locus are associated with sustained virological response to antiviral therapy and with spontaneous Hepatitis C Virus (HCV) clearance. Prevalence of these SNPs varies depending on ethnicity. The impact of IL28B SNPs in HCV-infected patients is currently unknown in Uruguay. Therefore, the aim of this study was to evaluate and compare the distribution of polymorphisms in the IL28B gene (rs12979860 and rs8099917) among HCV-infected patients and healthy individuals in Uruguay and thus assess their possible association with the establishment of HCV infection...
March 2, 2018: Virology Journal
https://www.readbyqxmd.com/read/29484189/race-affects-svr12-in-a-large-and-ethnically-diverse-hepatitis-c-infected-patient-population-following-treatment-with-direct-acting-antivirals-analysis-of-a-single-center-department-of-veterans-affairs-cohort
#9
Jihane N Benhammou, Tien S Dong, Folasade P May, Jenna Kawamoto, Ram Dixit, Samuel Jackson, Vivek Dixit, Debika Bhattacharya, Steven B Han, Joseph R Pisegna
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. HCV cure has been linked to improved patient outcomes. In the era of direct-acting antivirals (DAAs), HCV cure has become the goal, as defined by sustained virological response 12 weeks (SVR12) after completion of therapy. Historically, African-Americans have had lower SVR12 rates compared to White people in the interferon era, which had been attributed to the high prevalence of non-CC interleukin 28B (IL28B) type. Less is known about the association between race/ethnicity and SVR12 in DAA-treated era...
April 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29446443/association-of-killer-cell-immunoglobulin-like-receptors-with-spontaneous-clearance-of-hepatitis-c-virus-in-the-chinese-population
#10
Zhengang Shan, Jieting Huang, Qiao Liao, Ke Huang, Min Wang, Ru Xu, Xi Tang, Weiyun Zhang, Kenrad Nelson, Yongshui Fu, Chengyao Li, Xia Rong
BACKGROUND: Natural killer (NK) cells are critical components in innate immune response to viral infection. Killer cell immunoglobulin-like receptors (KIRs) are involved in regulating the balance of activation or inhibitory function of NK cells. However, the association of KIRs with the spontaneous clearance of hepatitis C virus (HCV) remains unclear in the Chinese population. STUDY DESIGN AND METHODS: A total of 407 HCV-seropositive voluntary blood donors were recruited, including 203 with spontaneous viral clearance and 204 with chronic infection...
February 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29429413/a-case-of-a-patient-infected-with-a-hepatitis-c-virus-genotype-3a-multidrug-resistant-variant-in-pakistan
#11
Asad Zia, Muhammad Ali, Hafsa Aziz, Muhammad Zia, Zabta Khan Shinwari, Abida Raza
BACKGROUND: Approximately 10 million people in Pakistan are infected with the hepatitis C virus (HCV). Most patients develop chronic hepatitis, with rare cases of spontaneous clearance. However, little is known about multidrug resistant viral variants in Pakistan. FINDINGS: This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in 2003. After an initial diagnosis of viral infection, the patient remained treatment naïve for 5 years...
February 11, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29380700/role-of-interleukin-28b-polymorphisms-in-response-to-interferon-based-therapy-for-hepatitis-c-virus-clearance
#12
Manu Asthana, Sushil Kumar Sahu, Amit Kumar, Suchitra Mohanty, Sudipta Chakrabarti, Piyanki Das, Nabanita Roy Chattopadhya, Koustav Chatterjee, Shivaram Prasad Singh, Shanmugam Rajasubramaniam, Tathagata Choudhuri
Interleukin-28B (IL28B) locus on a human chromosomal region 19q13 is responsible for immune protection against viruses. IL28B in hepatitis C virus (HCV) infection determines the fate of infection towards causing spontaneous clearance or chronic liver infection. Choice of treatment in chronic hepatitis C infection includes use of direct acting antivirals, pegylated-interferon (PEG-IFN) or ribavirin (RBV) therapy. Interferon free regimens are also suggested to be useful in drug resistant patients. Genome-wide association studies (GWAS), comprehensive meta-analysis and independent case-control studies in different ethnic populations have demonstrated association between certain Il-28B polymorphisms and its effect on the response to PEG-IFN-RBV therapy in HCV patients...
January 28, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29369421/genetic-variation-in-il28b-ifnl3-and-response-to-interferon-alpha-treatment-in-myeloproliferative-neoplasms
#13
Marie Lindgren, Jan Samuelsson, Lars Nilsson, Håvar Knutsen, Waleed Ghanima, Johan Westin, Peter L Johansson, Björn Andréasson
OBJECTIVE: In myeloproliferative neoplasms (MPN) interferon-alpha (IFN-α) is an effective treatment with disease-modifying properties but currently with no clear predictors of treatment outcome. Recent genome-wide association studies in chronic hepatitis C, have found a strong influence of genetic polymorphism near the IL28B (IFNL3) gene on response to IFN-α treatment. In this study we sought to evaluate the prognostic impact of IL28B rs12979860, rs8099917 and rs12980275 on IFN-α treatment response in myeloproliferative neoplasms...
January 25, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29354660/the-effect-of-shorter-treatment-regimens-for-hepatitis-c-on-population-health-and-under-fixed-budgets
#14
Jake R Morgan, Arthur Y Kim, Susanna Naggie, Benjamin P Linas
Background: Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and cost-effectiveness of 8 vs 12 weeks of therapy in treatment-naïve, noncirrhotic, genotype 1 HCV-infected black and nonblack individuals and considered scenarios of IL28B and NS5A resistance testing to determine treatment duration in sensitivity analyses...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29340806/distribution-of-il28b-and-il10-polymorphisms-as-genetic-predictors-of-treatment-response-in-pakistani-hcv-genotype-3-patients
#15
Humaira Naeemi, Rabia Aslam, Syed Mohsin Raza, Muhammad Aiman Shahzad, Shagufta Naz, Sobia Manzoor, Saba Khaliq
There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pathogenesis and clearance of HCV, and sustained virologic response (SVR). An interleukin 28B (IL28B) gene polymorphism has been shown to modify treatment outcomes, but the effects of interleukin 10 (IL10) polymorphisms have not been previously assessed in the Pakistani population...
April 2018: Archives of Virology
https://www.readbyqxmd.com/read/29285382/-il18-rs360719-a-g-il18r1-rs13015714-g-t-il18rap-rs917997-c-t-and-il28b-rs8099917-t-g-polymorphisms-and-risk-of-gastric-cardiac-adenocarcinoma
#16
Jun Yin, Changqing Dong, Weifeng Tang, Ruiping Liu, Suocheng Chen, Liang Zheng, Haiyong Gu
The present study was conducted to investigate the association between gastric cardiac adenocarcinoma (GCA) and four functional single-nucleotide polymorphisms (SNPs), including interleukin 18 ( IL18 ) rs360719 A>G, IL18 receptor 1 (IL18R1) rs13015714 G>T, IL18 receptor accessory protein (IL18RAP) rs917997 C>T and interleukin 28B (IL28B) rs8099917 T>G variants. A hospital-based case-control study was performed to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29284412/ccl4-is-the-only-predictor-for-non-responder-in-gt-1-chc-patients-with-favorable-il28b-genotype-when-treated-with-pegifn-rbv
#17
Chia-Chen Lin, Shih-Huan Su, Wen-Juei Jeng, Chien-Hao Huang, Wei Teng, Wei-Ting Chen, Yi-Cheng Chen, Chun-Yen Lin, I-Shyan Sheen
BACKGROUND: Chemokines/cytokines play important roles in the pathogenesis of chronic hepatitis C (CHC). However, their clinical characteristics and implications in treatment responses to pegylated interferon plus ribavirin treatment (PegIFN/RBV) have not been fully illustrated yet. In this study, we intended to investigate the possible predictability of serum chemokines/cytokines on the treatment response in Taiwanese of CHC, genotype-1 (GT-1). METHODS: 60 Patients with GT-1 CHC infection who had been treated with PegIFN/RBV were enrolled, including 27 (45%) with sustained virological response (SVR), 11 (18%) with relapse after 48 weeks of treatment and 22 (37%) non-response (NR)...
December 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29279441/data-mining-and-machine-learning-algorithms-using-il28b-genotype-and-biochemical-markers-best-predicted-advanced-liver-fibrosis-in-chronic-hepatitis-c
#18
Hend Ibrahim Shousha, Abubakr Hussein Awad, Dalia Abdelhamid Omran, Mayada Mohamed Elnegouly, Mahasen Mabrouk
IL28B single nucleotide polymorphism (rs12979860) is an etiology-independent predictor of hepatitis C virus (HCV)-related hepatic fibrosis. Data mining is a method of predictive analysis which can explore tremendous volumes of information from health records to discover hidden patterns and relationships. The current study aims to evaluate and compare the prediction accuracy of scoring system like aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4) index versus data mining for the prediction of HCV-related advanced fibrosis...
January 23, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29278743/expression-and-purification-of-biologically-active-bovine-interferon-%C3%AE-3-il28b-in-pichia-pastoris
#19
S Barathiraja, P A V Gangadhara, V Umapathi, H J Dechamma, G R Reddy
Interferon lambda-3 (IFNλ3) which is also known as IL28B is a member of type III Interferons which are structurally and genetically different from type I Interferons. These Interferons induce signal transduction pathways similar to type I Interferons which results in the activation of Interferon Stimulated Genes (ISGs). This group of Interferons are tissue specific and reported to have antiviral activity. In the present communication, we report the expression of bovine IFNλ3 gene (coding for the mature protein) in Pichia pastoris, purification of the expressed protein and evaluation of its biological activity...
May 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29247709/single-nucleotide-polymorphism-rs1800872-in-the-promoter-region-of-the-il10-gene-is-associated-with-predisposition-to-chronic-hepatitis-c-in-russian-population
#20
Andrey V Barkhash, Galina V Kochneva, Elena V Chub, Aida G Romaschenko
Previously, we studied an association of two IL28B gene single nucleotide polymorphisms (SNPs) and three IL10 gene SNPs with predisposition to tick-borne encephalitis in a Russian population. In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused by structurally similar, related virus from the Flaviviridae family) was investigated in the same population. Only the IL10 promoter rs1800872 SNP was associated with predisposition to chronic hepatitis C...
March 2018: Microbes and Infection
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