Marta Bodro, Carlos Cervera, Laura Linares, Belén Suárez, Jaume Llopis, Gemma Sanclemente, Sergi Casadó-Llombart, Mario Fernández-Ruiz, María Carmen Fariñas, Sara Cantisan, Miguel Montejo, Elisa Cordero, Isabel Oriol, María Angeles Marcos, Francisco Lozano, Asunción Moreno
Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period...
2022: Frontiers in Immunology