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https://www.readbyqxmd.com/read/28719042/serotonergic-paraneurons-in-the-female-mouse-urethral-epithelium-and-their-potential-role-in-peripheral-sensory-information-processing
#1
F Aura Kullmann, Huiyi H Chang, Christian Gauthier, Bronagh M McDonnell, Jih-Chao Yeh, Dennis R Clayton, Anthony J Kanai, William C de Groat, Gerard L Apodaca, Lori A Birder
AIM: The mechanisms underlying detection and transmission of sensory signals arising from visceral organs, such as the urethra, are poorly understood. Recently, specialized ACh-expressing cells embedded in the urethral epithelium have been proposed as chemosensory sentinels for detection of bacterial infection. Here we examined the morphology and potential role in sensory signaling of a different class of specialized cells that express serotonin (5-HT), termed paraneurons. METHODS: Urethrae, dorsal root ganglia neurons and spinal cords were isolated from adult female mice and used for immunohistochemistry and calcium imaging...
July 18, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28717639/commentary-complete-cranial-iliac-osteotomy-to-approach-the-lumbosacral-foramen
#2
COMMENT
Francois-Guillaume Saulnier Troff, Luca Motta, Virginie De Busscher
No abstract text is available yet for this article.
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28717058/lumbosacral-transitional-vertebrae-cause-spinal-level-misconception-in-surgeries-for-degenerative-lumbar-spine-disorders
#3
Tomowaki Nakagawa, Ko Hashimoto, Takumi Tsubakino, Takeshi Hoshikawa, Takashi Inawashiro, Yasuhisa Tanaka
Human lumbar spine usually consists of five vertebrae; however, some individuals have vertebral anomalies with four or six lumbar vertebrae because of sacralized fifth lumbar vertebra (L5 sacralization) or lumbarized first sacral vertebra (S1 lumbarization), respectively. These vertebral anomalies are called lumbosacral transitional vertebra (LSTV). Although LSTV is an asymptomatic anomaly, it is known to cause misconception in spinal counts and in spinal level at lumbar spinal surgery. The purpose of this study is to evaluate how LSTV affects the diagnosis and surgeries in lumbar spine disorders...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28712050/spatiotemporal-expression-of-bcl-2-bax-and-neural-cell-apoptosis-in-the-developing-lumbosacral-spinal-cord-of-rat-fetuses-with-anorectal-malformations
#4
Zhonghua Yang, Yuanyuan Geng, Zhiya Yao, Huimin Jia, Yuzuo Bai, Weilin Wang
Fecal incontinence and constipation still remain the major complications after procedures for anorectal malformations (ARMs). Previous studies have demonstrated a decrease of neural cell in lumbosacral spinal cord of ARMs patients and rat models. However, the underlying mechanism remains elusive. In this study, the neural cell apoptosis and Bcl-2/Bax expression were explored during lumbosacral spinal cord development in normal and ARMs fetuses. ARMs rat fetuses were induced by treating pregnant rats with ethylenethiourea on embryonic day 10...
July 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28711467/retrospective-study-of-jellyfish-envenomation-in-emergency-wards-in-guadeloupe-between-2010-and-2016-when-to-diagnose-irukandji-syndrome
#5
Djoudi Bouyer-Monot, Stéphane Pelczar, Serge Ferracci, Denis Boucaud-Maitre
BACKGROUND: In Guadeloupe (French West Indies), many marine envenomation cases by jellyfish are observed. Some of them might induce an Irukandji syndrome (IS). The aim of this study was to analyse the clinical features of IS from the envenomation cases in the two public hospitals in Guadeloupe, and to compare them to non-IS stings. METHODS: All jellyfish envenomation cases between the 1st of January 2010 and the 1st of September 2016, from the emergencies data-base, have been extracted...
July 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28710888/chronic-spinal-cord-injury-causes-up-regulation-of-serotonin-5-ht-2a-and-2c-receptors-in-lumbosacral-cord-motoneurons
#6
Nailong Cao, Jianshu Ni, Xiaohu Wang, Hongjian Tu, Baojun Gu, Jiemin Si, Gang Wu, Karl-Erik Andersson
OBJECTIVES: To explore if the mechanism of the voiding dysfunction caused by spinal cord injury in rats can be improved by intravenous administration of the 5-HT2A/2C receptor agonist, DOI, and discuss whether it can be ascribed to serotonin 2A and 2C receptor up-regulation in lumbosacral cord motoneurons. MATERIALS AND METHODS: Female Sprague-Dawley rats were used, which were divided into two groups (Spinal cord injury group VS Normal control group). Under urethane anesthesia, cystometry was performed to examine the variation of urodynamic parameters before and after successive intrathecal administration of various doses of DOI into the lumbosacral cord...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28710047/intradural-intramedullary-teratoma-presenting-in-the-lumbar-spine-report-of-a-rare-case
#7
Alireza Mohammadi, Taha Fereydouni, Ali Rahbari, Peyman Mokarian, Zoha Khademi
BACKGROUND: Intradural teratoma is an exceedingly unusual phenomenon. They are tumors with the cellular constituent source of all the three germ cell layers. CASE DESCRIPTION: We here report a case of an 18-year-old male with special pathological features. There was no history of spinal dysraphism, congenital spinal abnormalities, previous spinal surgery, or lumbar puncture. Lumbosacral spine magnetic resonance imaging revealed a well-delineated, intramedullary mass at the L2-L3 levels of the lumbar spine...
July 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28707222/considering-the-inferior-surface-area-of-lower-lumbar-vertebrae-determining-weight-transmission-pattern-at-the-lumbosacral-junction
#8
Uchenna Kenneth Ezemagu, Chike P Anibeze, Chinedu F Akpuaka
The biomechanical function of the lumbosacral junction (LSJ) is obscure, but its medical significance is not, as it is the most common site of low back pain. In this study, we analyzed the difference between the mean values of the surface areas of the inferior body and total inferior facet areas of the fourth and fifth lumbar vertebrae. We aimed to define the function of the LSJ during weight transmission and clarify its mechanical significance. Vertebral columns of 45 adult male human cadavers from five anatomy departments in Nigeria were cut at the L3-L4 intervertebral disc and macerated...
July 13, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28706767/surgical-excision-of-a-symptomatic-thoracic-nerve-root-perineural-cyst-resulting-in-complete-resolution-of-symptoms-a-case-report
#9
Zaid Aljuboori, Alae Yaseen, Jessica Simpson, Maxwell Boakye
Tarlov (perineural) cysts of the nerve root are common and usually incidental findings during magnetic resonance imaging (MRI) of the lumbosacral spine. There are a few case reports where symptomatic thoracic perineural cysts have been described in the literature. We report a case of a high thoracic nerve root perineural cyst that failed conservative therapy, requiring surgical intervention. Our patient presented with radicular symptoms involving the left hand. Imaging workup revealed a cystic lesion of the left T1 nerve root at the level of the foramen...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28705774/asia-a-sensory-and-motor-complete-is-not-different-than-asia-b-sensory-incomplete-motor-complete-in-gunshot-related-spinal-cord-injury
#10
Eric McCoy, Nima Eftekhary, Kenneth Nwosu, Dudley Fukunaga, Charles Liu, Kevin Rolfe
Background Context We receive a large number of spinal cord injury (SCI) patients due to penetrating gunshot wounds (GSW) at our national rehabilitation center. Though many patients are labeled American Spinal Injury Association (ASIA) B sensory incomplete due to sensory sparing, especially deep anal pressure, with purported prognostic value, we have not observed a clinical difference from ASIA A completes. We hypothesized that sensory sparing, if meaningful, should reduce the occurrence of pressure ulcers...
July 10, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28705257/single-stage-transforaminal-decompression-debridement-interbody-fusion-and-posterior-instrumentation-for-lumbosacral-brucellosis
#11
Yakefu Abulizi, Wei-Dong Liang, Aikeremujiang Muheremu, Maierdan Maimaiti, Wei-Bin Sheng
BACKGROUND: Spinal brucellosis is a less commonly reported infectious spinal pathology. There are few reports regarding the surgical treatment of spinal brucellosis in existing literature. This retrospective study was conducted to determine the effectiveness of single-stage transforaminal decompression, debridement, interbody fusion, and posterior instrumentation for lumbosacral spinal brucellosis. METHODS: From February 2012 to April 2015, 32 consecutive patients (19 males and 13 females, mean age 53...
July 14, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28705124/the-accuracy-and-safety-of-fluoroscopic-guided-percutaneous-pedicle-screws-in-the-thoracic-and-lumbosacral-spine-in-the-asian-population-a-ct-scan-analysis-of-1002-screws
#12
Chee Kidd Chiu, Chris Yin Wei Chan, Mun Keong Kwan
PURPOSE: This study investigates the safety and accuracy of percutaneous pedicle screws placed using fluoroscopic guidance in the thoracolumbosacral spine among Asian patients. METHODS: Computerized tomography scans of 128 patients who had surgery using fluoroscopic-guided percutaneous pedicle screws were selected. Medial, lateral, superior, and inferior screw perforations were classified into grade 0 (no violation), grade 1 (<2 mm perforation), grade 2 (2-4 mm perforation), and grade 3(>4 mm perforation)...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28691168/phenotyping-of-lumbosacral-stenosis-in-labrador-retrievers-using-computed-tomography
#13
Meenakshi Mukherjee, Jeryl C Jones, Ida Holásková, Raymond Raylman, Jean Meade
Deep phenotyping tools for characterizing preclinical morphological conditions are important for supporting genetic research studies. Objectives of this retrospective, cross-sectional, methods comparison study were to describe and compare qualitative and quantitative deep phenotypic characteristics of lumbosacral stenosis in Labrador retrievers using computed tomography (CT). Lumbosacral CT scans and medical records were retrieved from data archives at three veterinary hospitals. Using previously published qualitative CT diagnostic criteria, a board-certified veterinary radiologist assigned dogs as either lumbosacral stenosis positive or lumbosacral stenosis negative at six vertebral locations...
July 9, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28686145/minimally-invasive-dual-iliac-screw-dual-rod-fixation-in-a-rare-case-of-pathological-sacral-fracture-from-a-paraganglionoma-a-technique-description
#14
Muhammed Yaser Hasan, Gabriel Liu
The management of lumbosacral neoplastic disease can be demanding, often requiring complex reconstruction. In the context of extensive sacral involvement, the risk of iliac screw breakage is greater. Few studies advocate the use of dual iliac screw techniques to reduce implant failure. In this report, the authors have described the first case of percutaneous dual iliac screw, dual rod insertion as part of a minimally invasive spinopelvic stabilization in a patient with a sacral fracture from a paraganglionoma...
July 7, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28686126/impact-of-magnetic-resonance-imaging-and-urodynamic-studies-on-the-management-of-sacrococcygeal-dimples
#15
Goichiro Tamura, Nobuhito Morota, Satoshi Ihara
OBJECTIVE Sacrococcygeal dimples in neonates and infants are of uncertain pathological import. Previously they were believed to be rarely associated with intraspinal anomalies. Recent studies using MRI, however, revealed that 6%-7% of pediatric cases of sacrococcygeal dimples were associated with anatomical tethered spinal cord (TSC). Because the prevalence of tethered cord syndrome is still unclear, there is no consensus among pediatric neurosurgeons on the management of children with sacrococcygeal dimples...
July 7, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28684369/concomitant-lumbosacral-perimedullary-arteriovenous-fistula-and-spinal-dural-arteriovenous-fistula-a-case-report
#16
Jingwei Li, Guilin Li, Lisong Bian, Tao Hong, Jiaxing Yu, Hongqi Zhang, Feng Ling
BACKGROUND: and Importance Although multifocal spinal arteriovenous malformations (SAVMs) have been reported before, the present case is the first case of two different types, including perimedullary arteriovenous fistula (PMAVF) and spinal dural arteriovenous fistulas (SDAVFs) of lumbosacral arteriovenous malformations (AVMs), coexisting in one patient. We also report the use of hybrid techniques in the treatment of concomitant lumbosacral SAVMs for the first time. CLINICAL PRESENTATION: A 65-year-old man presented with a 4-year history of progressive sensory, motor, and sphincter dysfunction...
July 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28680780/immediate-remote-cerebellar-hemorrhage-and-seizure-following-revision-lumbosacral-fusion
#17
Alvin Y Chan, Jeffrey P Mullin, Edward Benzel, William Bingaman
Cerebellar hemorrhage (CH) is a rare but devastating complication following spine surgery. It is associated with a compromise to dura integrity and typically has a delayed post-operative onset. Here, we describe a patient who suffered a CH that presented with a generalized tonic-clonic (GTC) seizure immediately after a revision lumbar fusion. The patient did not regain consciousness from anesthesia prior to the hemorrhage. There are no reports indicating that CHs can occur abruptly following a spine surgery...
May 30, 2017: Curēus
https://www.readbyqxmd.com/read/28680729/long-iliac-screw-fixation-in-a-case-of-isthmic-spondyloptosis
#18
Marcelo D Vilela, Bruno P Braga, Hugo A S Pedrosa
BACKGROUND: We report the case of a patient with a spondyloptosis who presented with progressive deformity and worsening neurological deficits. The patient had two previous lumbosacral instrumented fusions. CASE DESCRIPTION: A salvage revision surgery was performed, in which long iliac screws along with anterior column support at L5-S1 were used to immobilize the lumbosacral junction. Two years after the procedure a solid fusion is seen along with marked neurological improvement...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28678646/pain-areas-and-mechanosensitivity-in-patients-with-chronic-pelvic-pain-syndrome-a-controlled-clinical-investigation
#19
Jörgen Quaghebeur, Jean-Jacques Wyndaele, Stefan De Wachter
OBJECTIVE: A thorough clinical assessment including physical examination is crucial in a diagnostic work-up, including in patients with chronic pelvic pain syndrome (CPPS). This study investigated the prevalence of pain areas and the mechanosensitivity of peripheral nerves in patients with CPPS and compared the findings with a healthy control group. MATERIALS AND METHODS: Healthy volunteers and patients diagnosed with CPPS were assessed with physical examinations and neurodynamic testing...
July 5, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28676359/office-evaluation-of-pelvic-pain
#20
REVIEW
Stacey Bennis, Sarah Hwang
The history and physical examination are important keys to diagnosis and treatment of patients with chronic pelvic pain. The comprehensive history should include questioning regarding patient's pain complaint and a thorough history and review of any body system that may be involved, including neuromusculoskeletal, obstetric, gynecologic, gastrointestinal, urologic, dermatologic, infectious, oncologic, and psychiatric. The physical examination should also follow a focused systems-based approach and includes examination of gastrointestinal, dermatologic, neurologic, and musculoskeletal (including lumbosacral spine, sacroiliac joints, pelvis, and hips) systems, and the pelvic floor (internal and external examination, including neuromuscular anatomy)...
August 2017: Physical Medicine and Rehabilitation Clinics of North America
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