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Dactylitis infant

A Aounallah, N Ghariani Fetoui, L Boussofara, S Mokni, W Saidi, C Belajouza, M Denguezli, N Ghariani, R Nouira
No abstract text is available yet for this article.
July 14, 2016: Annales de Dermatologie et de Vénéréologie
Jeremy C Sinkin, Benjamin C Wood, Tina M Sauerhammer, Michael J Boyajian, Gary F Rogers, Albert K Oh
Salmonella osteomyelitis involving the hand is a rare, but potentially morbid, complication of sickle cell disease in children. This entity can be difficult to distinguish from the more frequent presentation of dactylitis, but accurate diagnosis is critical to direct proper treatment. We report on a 15-month-old patient with sickle cell disease who ultimately developed osteomyelitis of 1 hand after an acute vasoocclusive episode caused 4 extremity dactylitis. The case description illustrates the diagnostic and treatment challenges...
January 2015: Plastic and Reconstructive Surgery. Global Open
S A Adegoke, O O Adeodu, A D Adekile
BACKGROUND: The clinical phenotypes of children with sickle cell disease (SCD) are poorly described in many sub-Saharan countries including Nigeria. OBJECTIVES: The objective was to highlight various clinical phenotypes of SCD in children and investigate the influence of sociodemographic indices on the development of SCD complications. METHODS: We carried out a cross-sectional study of 240 pediatric patients attending the sickle cell clinic and the emergency room in a teaching hospital in South-Western Nigeria over a 12-month period...
January 2015: Nigerian Journal of Clinical Practice
R Cohen, C Levy, J Cohen, F Corrard, P Deberdt, S Béchet, S Bonacorsi, Ph Bidet
Blistering distal dactylitis is a distinct clinical entity, generally due to S. pyogenes, unfrequently reported. Characteristically, blistering distal dactylitis is described as a localized infection involving the distal phalanx of the digits, and it usually presents as a fluid-filled blister. Between October 2009 and June 2014, 69 children (median age: 60 months, extremes: 0,6-176) were enrolled. The sensitivity of GAS rapid antigen detection test was 97 % (CI 95 %: 83-100 %), the specificity was 76 % (CI 95 %: 60-89 %), the negative predictive value was 97 % (CI 95 %: 83-100 %), and the positive predictive value 76 % (CI 95 %: 60-89 %)...
November 2014: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Inês Vaz Silva, Ana Filipa Reis, Maria João Palaré, Anabela Ferrão, Teresa Rodrigues, Anabela Morais
BACKGROUND: Sickle cell disease (SCD) has extremely variable phenotypes, and several factors have been associated with the severity of the disease. OBJECTIVES: To analyze the chronic complications of SCD and look for predictive risk factors for increased severity and number of complications. METHODS: Retrospective study including all children followed for SCD in the Paediatric Haematology Unit of a tertiary hospital in Portugal, who completed 17 yr old between the years 2004 and 2013...
February 2015: European Journal of Haematology
Emily Riehm Meier, Elizabeth C Wright, Jeffery L Miller
Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the ages of 1 and 2 years as markers of severe disease. Reticulocytosis was also associated with severe disease. Here, we further analyzed data collected on enrolled CSSCD infants for the predictive value of those markers for stroke and death later in life. Three hundred fifty-four CSSCD subjects were identified who had absolute reticulocyte counts (ARC) measured during infancy (2 to 6 months of age)...
September 2014: American Journal of Hematology
Carlton Dampier, Beth Ely, Darcy Brodecki, Camille Coleman, Leela Aertker, Jocelyn Andrel Sendecki, Benjamin Leiby, Karen Kesler, Terry Hyslop, Marie Stuart
BACKGROUND: The epidemiology of painful episodes in infants and younger children with SCD has not been well studied, particularly for pain managed at home. PROCEDURE: SCD infants identified by newborn screening were enrolled in a longitudinal observational study of pain symptoms requiring parents to report the presence or absence of pain daily. When sickle cell related-pain events occurred, pain occurrence, location, associated symptoms and the treatment provided also were reported...
February 2014: Pediatric Blood & Cancer
C Ndugwa, D Higgs, C Fisher, I Hambleton, K Mason, B E Serjeant, G R Serjeant
OBJECTIVE: To compare the haematological and clinical features of homozygous sickle cell (SS) disease in Bantu and Benin haplotypes in a cross-sectional study of 115 Ugandan patients attending the Sickle Cell Clinic at Mulago Hospital, Kampala, Uganda, with 311 patients in the Jamaican Cohort Study METHODS: This involved comparison of clinical features and haematology with special reference to genetic determinants of severity including fetal haemoglobin levels, beta-globin haplotype and alpha thalassaemia status...
October 2012: West Indian Medical Journal
Yu-Mei Chen, Min Ruan, Yao Zou, Ye Guo, Shu-Chun Wang, Xiao-Juan Chen, Li Zhang, Tian-Feng Liu, Xiao-Fan Zhu
This study was aimed to explore the mutations of ribosomal protein (RP) genes in patients with Diamond Blackfan anemia (DBA). Twenty-one cases of DBA admitted in our hospital from Dec 2008 to Aug 2012 were screened by PCR for mutations in the nine known genes associated with DBA: RPS19, RPS24, RPS17, RPL5, RPL11, RPS7, RPL35a, RPS10 and RPS26. The results found that 8 patients (38.1%) with DBA had mutations in the genes coding for ribosomal protein, in which RPS19 mutation was identified in 3 patients, RPS24, RPS7, RPL5, RPL11 and RPL35A mutations were identified respectively in 1 of the patient...
December 2012: Zhongguo Shi Yan Xue Ye Xue za Zhi
Hong-Ling Wei, Shan Lu, Hui-Qiang Liu
No abstract text is available yet for this article.
December 2012: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Courtney D Thornburg, Beatrice A Files, Zhaoyu Luo, Scott T Miller, Ram Kalpatthi, Rathi Iyer, Phillip Seaman, Jeffrey Lebensburger, Ofelia Alvarez, Bruce Thompson, Russell E Ware, Winfred C Wang
The Pediatric Hydroxyurea Phase 3 Clinical Trial (BABY HUG) was a phase 3 multicenter, randomized, double-blind, placebo-controlled clinical trial of hydroxyurea in infants (beginning at 9-18 months of age) with sickle cell anemia. An important secondary objective of this study was to compare clinical events between the hydroxyurea and placebo groups. One hundred and ninety-three subjects were randomized to hydroxyurea (20 mg/kg/d) or placebo; there were 374 patient-years of on-study observation. Hydroxyurea was associated with statistically significantly lower rates of initial and recurrent episodes of pain, dactylitis, acute chest syndrome, and hospitalization; even infants who were asymptomatic at enrollment had less dactylitis as well as fewer hospitalizations and transfusions if treated with hydroxyurea...
November 22, 2012: Blood
T L Skare, N Leite, A B Bortoluzzo, C R Gonçalves, J A B da Silva, A C Ximenes, M B Bértolo, S L E Ribeiro, M Keiserman, R Menin, S Carneiro, V F Azevedo, W P Vieira, E das N Albuquerque, W A Bianchi, R Bonfiglioli, C Campanholo, H M S Carvalho, I P Costa, A P Duarte, M B O Gavi, C L Kohem, S A L Lima, E S Meirelles, I A Pereira, M M Pinheiro, E Polito, G G Resende, F A C Rocha, M B Santiago, M de F L C Sauma, P D Sampaio-Barros
OBJECTIVES: To analyse demographic and clinical variables in patients with disease onset before and after 40, 45 and 50 years in a large series of Brazilian SpA patients. METHODS: A common protocol of investigation was prospectively applied to 1424 SpA patients in 29 centres distributed through the main geographical regions in Brazil. The mean age at disease onset was 28.56 ± 12.34 years, with 259 patients (18.2%) referring disease onset after 40 years, 151 (10...
May 2012: Clinical and Experimental Rheumatology
Clare Wykes, David C Rees
The BABYHUG study is the first randomized controlled prospective trial of hydroxycarbamide in infants with sickle cell anemia to look at its effect on organ function. Almost 200 patients were recruited, irrespective of disease severity, over a 3-year period and followed for 2 years. The primary end points of splenic function and glomerular filtration rate were not reached. The trial did show a benefit in frequency of pain, dactylitis, acute chest syndrome, hospital admissions and transfusion requirements. Adverse effects were low...
August 2011: Expert Review of Hematology
Matthew L Stoll, Marilynn Punaro
PURPOSE OF REVIEW: The International League of Associations for Rheumatology criteria parse out juvenile idiopathic arthritis (JIA) into seven groups, with the aim of creating homogeneous subgroups suitable for clinical and research evaluation. However, prior studies have shown that psoriatic JIA (psJIA) may be a heterogeneous entity. RECENT FINDINGS: PsJIA is composed of two subgroups, differentiated by age at onset. Older children with psJIA have features of spondyloarthritis, including relative male preponderance, increased risk of axial involvement, and enthesitis...
September 2011: Current Opinion in Rheumatology
Winfred C Wang, Russell E Ware, Scott T Miller, Rathi V Iyer, James F Casella, Caterina P Minniti, Sohail Rana, Courtney D Thornburg, Zora R Rogers, Ram V Kalpatthi, Julio C Barredo, R Clark Brown, Sharada A Sarnaik, Thomas H Howard, Lynn W Wynn, Abdullah Kutlar, F Daniel Armstrong, Beatrice A Files, Jonathan C Goldsmith, Myron A Waclawiw, Xiangke Huang, Bruce W Thompson
BACKGROUND: Sickle-cell anaemia is associated with substantial morbidity from acute complications and organ dysfunction beginning in the first year of life. Hydroxycarbamide substantially reduces episodes of pain and acute chest syndrome, admissions to hospital, and transfusions in adults with sickle-cell anaemia. We assessed the effect of hydroxycarbamide therapy on organ dysfunction and clinical complications, and examined laboratory findings and toxic effects. METHODS: This randomised trial was undertaken in 13 centres in the USA between October, 2003, and September, 2009...
May 14, 2011: Lancet
Phu Quoc Lê, A Ferster, F Cotton, F Vertongen, C Vermylen, A Vanderfaeillie, L Dedeken, C Heijmans, O Ketelslegers, M F Dresse, B Gulbis
AIM: To describe the severity of sickle cell disease (SCD) in newborns in Belgium and evaluate the impact of neonatal screening (NS) on clinical outcome. METHODS: Universal NS of umbilical cord blood for hemoglobinopathy was progressively deployed in Brussels and Liège starting in 1994. No particular population was targeted. Samples were analyzed initially using the isoelectric focusing technique and since 2008 the capillary electrophoresis technique. If a hemoglobin variant was suspected, further analysis was carried out using high performance liquid chromatography...
December 2010: Médecine Tropicale: Revue du Corps de Santé Colonial
Olusola A Oyedeji, Kehinde S Oluwadiya, Ademola A Aremu
HIV infection is rapidly emerging as a predominant cause of morbidity and mortality in children from developing countries. This probably accounts for the many reports that have emanated from resource-limited settings in the last decade. Reports highlighting bone infections and untoward complications in HIV-infected children are rare. This informed our decision to report the case of a 9-month-old HIV-positive Nigerian girl who presented with blistering dactylitis of the right middle finger. Plain radiograph of the right hand showed amputation of the terminal phalanx and changes consistent with osteomyelitis in the middle phalanx of the third finger...
September 2011: Journal of the International Association of Physicians in AIDS Care: JIAPAC
Andrew Fretzayas, Maria Moustaki, Vasilios Tsagris, Triantafillia Brozou, Polyxeni Nicolaidou
We describe a 6-month-old infant with blistering distal dactylitis. Bacterial culture from the skin lesion grew methicillin resistant Staphylococcus aureus. No carriage of this bacterial agent was identified in her family. She responded to vancomycin administration and incision and drainage of the lesion. This is the first reported case of methicillin resistant Staphylococcus aureus-associated blistering distal dactylitis in an infant.
July 2011: Pediatric Dermatology
B J Brown, B F Akinkunmi, O J Fatunde
In order to determine the age at diagnosis of sickle cell disease and some of the factors that influence the same at the University College Hospital Ibadan, a retrospective study of children with sickle cell disease who attended the children's outpatient department of the hospital between June 2000 and June 2009 was conducted by reviewing their case notes. A total of 457 children were studied (Male: Female ratio 1.1:1). Haemoglobin phenotype was SS in 421 children (92.1%) and SC in 36 children (7.9 %). Median age at diagnosis was 2...
September 2010: African Journal of Medicine and Medical Sciences
Susanna B Ali, Marvin Reid, Raphael Fraser, Michelle MooSang, Amza Ali
Although there is some evidence that epilepsy is more common in Sickle Cell Disease (SCD), we sought to establish the incidence rates, risk factors for and specific types of seizures in a SCD cohort followed from birth, and how seizure occurrence affects morbidity and mortality. We examined all records of persons in the Jamaica cohort Study of Sickle Cell Disease (JSSCD) clinically identified as having experienced a seizure during their lifetime. At first presentation, seizures were classified as Febrile Convulsion, Acute Symptomatic Seizure or Single Unprovoked Seizure...
November 2010: British Journal of Haematology
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