Michael Levine, Jeffrey Brent, Timothy Wiegand, Bryan Maguire, Neta Cohen, David Vaerrier, Michael Beuhler, Jerrold B Leikin, Michael Ganetsky, Samuel Stellpflug, Anne-Michelle Ruha, Jennifer Carey, Ann-Jeannette Geib, Dazhe James Cao, Kurt Kleinschmidt, Rais Vohra, Brad D Riley, Phillip Moore, Evan Schwarz, Mark Neavyn, Daniel E Rusyniak, Spencer Greene, Joshua Nogar, Alex Manini, Mary Wermuth, Anthony Pizon, Robert G Hendrickson, Matthew Griswold, Kim Aldy, Paul Wax, Meghan Beth Spyres, Sharan Campleman, Erin Macdonald, Yaron Finkelstein
BACKGROUND: Despite conflicting data, intravenous lipid emulsion has emerged as a potential antidote. The "lipid sink" theory suggests that following intravenous administration of lipid, lipophilic drugs are sequestered in the vascular compartment, thereby reducing their tissue concentrations. This study sought to determine if survival is associated with the intoxicant's degree of lipophilicity. METHODS: We reviewed all cases in the Toxicology Investigators Consortium's lipid sub-registry between May 2012 through December 2018...
August 2023: Clinical Toxicology