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Lipid emulsion therapy

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https://www.readbyqxmd.com/read/28161466/cmrna-lipoplex-encapsulation-in-plga-microspheres-enables-transfection-via-calcium-phosphate-cement-cpc-plga-composites
#1
Maximilian Utzinger, Anita Jarzebinska, Nicolas Haag, Martin Schweizer, Gerhard Winter, Christian Dohmen, Carsten Rudolph, Christian Plank
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by varying the extent of lipoplex loading into the polymer matrix...
February 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28098869/core%C3%A2-shell-lipid-polymer-nanoparticles-for-combined-chemo%C3%A2-and-gene-therapy-of-childhood-head-and-neck-cancers
#2
Tiesong Zhang, Jing Ma, Chao Li, Ken Lin, Fan Lou, Hongchao Jiang, Yingqin Gao, Yanli Yang, Cheng Ming, Biao Ruan
Pediatric head and neck cancers account for overall 12% of all pediatric cancers. Despite recent advances in therapeutic modalities, children with tumor metastasis have poor prognosis. Therefore, there is an unmet need for new and effective treatment modalities for pediatric head and neck cancers. The present study describes a simple and efficient method for fabrication of cationic lipid‑polymer hybrid nanoparticles (CLPNs) for co‑delivery of cisplatin (CDDP) and DNA (CDDP/DNA CLPNs) for the therapy of childhood head and neck cancers...
January 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28012788/lipid-therapy-for-intoxications
#3
REVIEW
Joris Henricus Robben, Marieke Annet Dijkman
This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances...
December 21, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27992937/parenteral-fish-oil-lipid-emulsions-in-the-prevention-of-severe-retinopathy-of-prematurity-a-systematic-review-and-meta-analysis
#4
Sakeer Vayalthrikkovil, Rani A Bashir, Yacov Rabi, Harish Amin, Jill-Marie Spence, Helen Lee Robertson, Abhay Lodha
Objective Omega-3 fatty acids are vital for brain and retinal maturation. It is not clear if early use of ω-3 fatty acids in the form of fish-oil lipid emulsions (FLEs) prevents retinopathy of prematurity (ROP) in preterm infants. The aim of this meta-analysis is to evaluate whether early administration of parenteral FLEs reduces ROP requiring laser therapy or severe ROP ≥stage 3 in preterm infants. Methods A literature search was performed to identify studies comparing parenteral FLEs with soybean-based lipid emulsions (SLEs) in preventing ROP...
December 19, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27966330/therapeutic-effects-of-intralipid-and-medialipid-emulsionsin-a-rat-model-of-verapamil-toxicity
#5
Fatma Akgün Şahin, Sıdıka Hülya Çelebi, İrfan Güngör, Demet Coşkun, Elif Ergüven Kaya
BACKGROUND/AIM: Lipid emulsions are promising as a potential new therapy for severe verapamil overdose. Our purpose is to draw attention to the choice of solution by investigating the efficacy of intralipid 20% or medialipid 20% in verapamil overdose. MATERIALS AND METHODS: Eighteen adult Sprague Dawley rats were randomly divided into three groups: control (saline; Group C), intralipid 20% (Group I), and medialipid 20% (Group M). Rats were anesthetized with ketamine...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27959295/intravenous-lipid-emulsion-for-management-of-systemic-toxic-effects-of-drugs
#6
Jaclyn O'Connor, Suprat Saely Wilson
The incidence of toxic effects of drugs leading to emergency department visits has increased in the United States in the past several years. Most of these patients can be adequately managed by supportive care alone. However, pharmacological antidotes may be necessary, particularly in patients with hemodynamic instability. In severe cases refractory to conventional antidote therapy, rescue therapy with intravenous lipid emulsion (ILE) may be necessary. Traditionally, ILE has been used as an antidote of choice in treating toxic effects of local anesthetics...
October 2016: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/27876104/a-cohort-study-of-unstable-overdose-patients-treated-with-intravenous-lipid-emulsion-therapy
#7
Shazma Mithani, Kathryn Dong, Ashlea Wilmott, Heather Podmoroff, Nadim Lalani, Rhonda J Rosychuk, Ryan Chuang, Mark C Yarema
OBJECTIVES: Intravenous lipid emulsion (ILE) has been used increasingly over the last decade for a range of drug overdoses. Although the use of ILE in local anesthetic toxicity (LAST) is well established, the hemodynamic effectiveness of ILE in non-LAST poisonings is still unclear. Thus, the primary objective of this study was to examine a cohort of poisoned patients in whom ILE was administered. METHODS: Consecutive patients were identified by calls to a regional poison center from May 1, 2012 to May 30, 2014...
November 23, 2016: CJEM
https://www.readbyqxmd.com/read/27851505/1870-intravenous-lipid-emulsion-therapy-as-an-antidote-to-lipophilic-medication-intoxication
#8
Jessica Cope, Herman Gaztambide, Martina Holder, Kristopher Kline, Hassan Alnuaimat, Jorge Lascano
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849101/-emergency-management-of-intoxications-in-the-dog-and-cat
#9
Esther Hassdenteufel, Hendrik Lehmann, Matthias Schneider, Andreas Moritz
Intoxications may lead to life-threatening emergencies. While stabilising the patient, therapy should focus on a rapid and effective elimination of the toxin. General measures for decontamination (gastrointestinal, dermal, ocular) aim to effectively decrease the absorption of the poisonous substance. Further classification of the substance and its properties can assist with the choice of specific treatment options, including dialysis and specific antidotal therapy. In recent years, treatment with lipid emulsions for enhanced elimination of lipophilic substances has become an important therapeutic option...
December 5, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27828934/review-of-intravenous-lipid-emulsion-therapy
#10
Jeffery W Spray
Intravenous fat emulsion (IVFE) is an important source of calories and essential fatty acids for patients receiving parenteral nutrition (PN). Administered as an individual infusion or combined with PN, the fats provided by IVFE are vital for cellular structural function and metabolism. The affinity of some medications to lipids has led to the use of IVFE as a treatment for any lipophilic drug overdose. This article will explain the available formulations of IVFE, administration, and maintenance issues, as well as the risks and benefits for various applications...
November 2016: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/27796907/formulation-optimization-characterization-and-pharmacokinetics-of-progesterone-intravenous-lipid-emulsion-for-traumatic-brain-injury-therapy
#11
Jin Zhao, Quan Yuan, WeiHui Cai, Pan Sun, LiYan Ding, Fang Jin
Traumatic brain injury (TBI) is a major cause of mortality and disability throughout the world. Progesterone (PROG) plays an important role in neurologic treatment. The aim of this study was to develop a progesterone formulation with good physical and chemical stability. Progesterone intravenous lipid emulsion (PILE) was prepared based on one-factor-at-a-time experiments and orthogonal design. The optimal PILE was evaluated for mean particle size, particle size distribution, zeta potential, morphology, pH, osmolarity, entrapment efficiency, storage stability, and pharmacokinetics in ICR mice compared with the commercial progesterone products...
October 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27749343/experts-consensus-recommendations-for-the-management-of-calcium-channel-blocker-poisoning-in-adults
#12
Maude St-Onge, Kurt Anseeuw, Frank Lee Cantrell, Ian C Gilchrist, Philippe Hantson, Benoit Bailey, Valéry Lavergne, Sophie Gosselin, William Kerns, Martin Laliberté, Eric J Lavonas, David N Juurlink, John Muscedere, Chen-Chang Yang, Tasnim Sinuff, Michael Rieder, Bruno Mégarbane
OBJECTIVE: To provide a management approach for adults with calcium channel blocker poisoning. DATA SOURCES, STUDY SELECTION, AND DATA EXTRACTION: Following the Appraisal of Guidelines for Research & Evaluation II instrument, initial voting statements were constructed based on summaries outlining the evidence, risks, and benefits. DATA SYNTHESIS: We recommend 1) for asymptomatic patients, observation and consideration of decontamination following a potentially toxic calcium channel blocker ingestion (1D); 2) as first-line therapies (prioritized based on desired effect), IV calcium (1D), high-dose insulin therapy (1D-2D), and norepinephrine and/or epinephrine (1D)...
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27662805/permeation-of-topically-applied-caffeine-from-a-food-by-product-in-cosmetic-formulations-is-nanoscale-in-vitro-approach-an-option
#13
Francisca Rodrigues, Ana Catarina Alves, Claudia Nunes, Bruno Sarmento, M Helena Amaral, Salette Reis, M Beatriz P P Oliveira
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers associated with caffeine extracted from Coffee Silverskin (NLC-CS), a food by-product, as a new possible topical therapy of cellulitis. Caffeine gain increasing research interest due to their cosmetic potential, particularly in gynoid lipodystrophy, commonly known as cellulite. NLC-CS were prepared via double emulsion technique using polysorbate 60 as surfactant and characterized for their morphology, particle size, zeta potential, association encapsulation and stability...
November 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27637335/the-impact-of-an-omega-3-fatty-acid-rich-lipid-emulsion-on-fatty-acid-profiles-in-critically-ill-septic-patients
#14
Thomas C Hall, Dilraj K Bilku, Christopher P Neal, Jill Cooke, Helena L Fisk, Philip C Calder, Ashley R Dennison
BACKGROUND: Death from sepsis in the intensive therapy unit (ITU) is frequently preceded by the development of multiple organ failure as a result of uncontrolled inflammation. Treatment with omega-3 (n-3) fatty acids (FAs), principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been demonstrated to attenuate the effects of uncontrolled inflammation and may be clinically beneficial in reducing mortality from organ dysfunction. Fish oil (FO) is a source of EPA and DHA...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27608281/evidence-based-recommendations-on-the-use-of-intravenous-lipid-emulsion-therapy-in-poisoning
#15
Sophie Gosselin, Lotte C G Hoegberg, Robert S Hoffman, Andis Graudins, Christine M Stork, Simon H L Thomas, Samuel J Stellpflug, Bryan D Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F Turgeon, Benoit Bailey, Diane P Calello, Ryan Chuang, Theodore C Bania, Bruno Mégarbane, Ashish Bhalla, Valéry Lavergne
BACKGROUND: Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations of toxicity. A collaborative workgroup appraised the literature and provides evidence-based recommendations for the use of ILE in poisoning. METHODS: Following a systematic review of the literature, data were summarized in four publications: LA and non-LA poisoning efficacy, adverse effects, and analytical interferences...
December 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27601899/cellular-uptake-mechanism-and-comparative-evaluation-of-antineoplastic-effects-of-paclitaxel-cholesterol-lipid-emulsion-on-triple-negative-and-non-triple-negative-breast-cancer-cell-lines
#16
COMPARATIVE STUDY
Jun Ye, Xuejun Xia, Wujun Dong, Huazhen Hao, Luhua Meng, Yanfang Yang, Renyun Wang, Yuanfeng Lyu, Yuling Liu
There is no effective clinical therapy for triple-negative breast cancers (TNBCs), which have high low-density lipoprotein (LDL) requirements and express relatively high levels of LDL receptors (LDLRs) on their membranes. In our previous study, a novel lipid emulsion based on a paclitaxel-cholesterol complex (PTX-CH Emul) was developed, which exhibited improved safety and efficacy for the treatment of TNBC. To date, however, the cellular uptake mechanism and intracellular trafficking of PTX-CH Emul have not been investigated...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27601177/ocular-amphotericin-b-delivery-by-chitosan-modified-nanostructured-lipid-carriers-for-fungal-keratitis-targeted-therapy
#17
Tian Fu, Jinglin Yi, Songyi Lv, Bing Zhang
CONTEXT: Fungal keratitis, a corneal fungal infection of the eye caused mainly by Candida species, has become the leading cause of blindness resulting from corneal disease in China. Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. OBJECTIVE: The aim of this study was to construct amphotericin B (AmB) loaded, chitosan-modified, nanostructured lipid carriers (AmB-CH-NLC) for prolonged ocular application and for the improvement of the targeted delivery of AmB to the ocular mucosa...
September 7, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27574883/favorable-outcomes-of-preterm-infants-with-pnald-treated-with-iv-fish-oil-based-lipid-emulsion
#18
Michael Sorrell, Alvaro Moreira, Kay Green, Rachel Jacobs, Robin Tragus, Laura Keller, Amy Quinn, Donald McCurnin, Alice Gong, Abeer El Sakka, Naveen Mittal, Cynthia Blanco
OBJECTIVES: To study the acute and long-term outcomes of preterm infants treated with an intravenous (IV) fish oil-based lipid emulsion (FishLE) for parenteral nutrition-associated liver disease (PNALD). METHODS: Preterm infants 14 days to 24 months of age with anatomic short gut or severe intestinal dysmotility, serum direct bilirubin ≥4 mg/dL, and requiring >60% calories from PN were eligible. Enrolled infants received 1 g/kg/day of FishLE until resolution of direct hyperbilirubinemia or return of enteral nutrition...
August 27, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27574721/on-the-thermodynamics-and-kinetics-of-superheated-fluorocarbon-phase-change-agents
#19
Paul A Mountford, Mark A Borden
Superheated nanodrops are a new class of submicron-diameter liquid emulsion particles comprising perfluoropropane (C3F8), perfluorobutane (C4F10) and perfluoropentane (C5F12) that are being developed for ultrasound imaging and therapy. They can be formed by condensation of precursor lipid-coated, gas-filled microbubbles. Application of ultrasound or laser energy triggers the phase transformation back to a vapor bubble, and this process can be exploited for certain biomedical applications. The nanodrops are remarkably metastable in the liquid state under physiological conditions, even though they are highly superheated...
August 18, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27548660/simultaneous-use-of-intravenous-lipid-emulsion-and-plasma-exchange-therapies-in-multiple-drug-toxicity
#20
Mucahit Avcil, Mucahit Kapçı, Irfan Yavaşoğlu, Burçak Kantekin, Mahmut Akpek
OBJECTIVE: The aim of this study was to highlight the use of combined intravenous lipid emulsion (ILE) and plasma exchange (PE) therapies in multidrug toxicity. CLINICAL PRESENTATION AND INTERVENTION: A 45-year-old woman who attempted suicide by ingesting large quantities of amisulpride (28 g), diazepam (250 mg), valsartan (2,240 mg), aripiprazole (45 mg) and paliperidone (21 mg) was taken to the hospital of Adnan Menderes University School of Medicine. Upon arrival, she exhibited signs of cardiotoxicity and severe depression of the central nervous and respiratory systems...
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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