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Mondfulness

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https://www.readbyqxmd.com/read/28808279/fine-tuning-and-mond-in-a-metamaterial-multiverse
#1
Igor I Smolyaninov, Vera N Smolyaninova
We consider the recently suggested model of a multiverse based on a ferrofluid. When the ferrofluid is subjected to a modest external magnetic field, the nanoparticles inside the ferrofluid form small hyperbolic metamaterial domains, which from the electromagnetic standpoint behave as individual "Minkowski universes" exhibiting different "laws of physics", such as different strength of effective gravity, different versions of modified Newtonian dynamics (MOND) and different radiation lifetimes. When the ferrofluid "multiverse" is populated with atomic or molecular species, and these species are excited using an external laser source, the radiation lifetimes of atoms and molecules in these "universes" depend strongly on the individual physical properties of each "universe" via the Purcell effect...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800416/the-enigma-of-male-eating-disorders-a-critical-review-and-synthesis
#2
REVIEW
Stuart B Murray, Jason M Nagata, Scott Griffiths, Jerel P Calzo, Tiffany A Brown, Deborah Mitchison, Aaron J Blashill, Jonathan M Mond
Historically, male presentations of eating disorders (EDs) have been perceived as rare and atypical - a perception that has resulted in the systematic underrepresentation of males in ED research. This underrepresentation has profoundly impacted clinical practice with male patients, in which i) stigmatization and treatment non-engagement are more likely, ii) a distinct array of medical complexities are faced, and iii) symptom presentations differ markedly from female presentations. Further, the marginalization of males from ED research has hindered the assessment and clinical management of these presentations...
August 2, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28797070/methyl-pyruvate-protects-a-normal-lung-fibroblast-cell-line-from-irinotecan-induced-cell-death-potential-use-as-adjunctive-to-chemotherapy
#3
Bernice Monchusi, Monde Ntwasa
The Warburg Effect, characterized by increased rate of glycolysis even under normoxic conditions, is one of the hallmarks of cancer. Relatively lower oxidative phosphorylation (OXPHOS) is also a characteristic feature in cancer cells. We hypothesized that interference with this phenomenon, by introducing exogenous pyruvate, would upset this cancer phenotype and boost the energy requirements of normal cells. We find that methyl pyruvate protects irinotecan-treated normal lung fibroblast cell line (MRC-5) probably by turning off the p53/p21 axis of the apoptotic pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28796461/ce-que-peut-la-sociologie
#4
Bernard Lahire
When it is relational, processual, and it articulates the incorporated dispositions of the actors and the contexts of their actions, sociology "desevidentialize," denaturalize, desubstantialize, and historicize the social world by contributing to do away with spontaneous representations that distort the reality of things. Besides, when sociology studies the social at the level of the individuals and individual actions, it destroys the fictions (juridical and philosophical) of the isolated individuals, enclosed on himself, free and fully conscious of everything...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28796452/in-praise-of-sociology
#5
Raewyn Connell
This reflection on the relevance of sociology starts with the different forms of social knowledge, and some autobiographical reflection on my engagement with the discipline. A research-based social science is made urgent by the prevalence of distortion and pseudoscience in the public realm. However, the research-based knowledge formation is embedded in a global economy of knowledge that centers on a privileged group of institutions and produces major imbalances on a world scale. Sociological data collection has important uses in policy and public discussion...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28796448/matters-of-scale-sociology-in-and-for-a-complex-world
#6
Olli Pyyhtinen
The article proposes that if sociology is to make sense of a world that is ever more complex and complicated, it is important to reconsider the scale(s) of our relations and actions. Instead of assuming a nested vertical hierarchy of the micro to macro binary, scale should be treated not only as multiple, but also as something produced and sustained in practice. Coming to grips with the complex world, we are living in also necessitates attending to the conduits and connections between various sites, fields, and terrains to which our lives are entangled...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28743439/the-electrocardiographic-footprints-of-wenckebach-block
#7
REVIEW
Harry G Mond, Jitendra Vohra
In 1899, Karel Frederik Wenckebach described a cardiac arrhythmia with periodic dropped beats now referred to as a Wenckebach sequence. This was later shown to be due to a block in the atrioventricular node, but today, we identify Wenckebach sequences throughout the heart with most being recognised on the surface electrocardiograph as characteristic footprints. This manuscript will revisit Wenckebach atrioventricular block, the typical features of which only occur in about 15% of cases, with the remainder atypical...
July 3, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28741501/retinoblastoma-binding-protein-6-another-p53-monitor
#8
Monde Ntwasa
The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, is essential for embryonic development. Its loss-of-function phenotype is similar to mouse double minute homolog (MDM2), the prototypical negative regulator of p53. This article draws attention to the molecular and biological functions of RBBP6 and to its association with carcinogenesis.
November 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28685195/characterization-of-three-pathway-specific-regulators-for-high-production-of-monensin-in-streptomyces-cinnamonensis
#9
Zheng-Kun Tang, Xiao-Mei Li, Ai-Ping Pang, Chun-Yan Lin, Yue Zhang, Jie Zhang, Jianjun Qiao, Guang-Rong Zhao
Monensin, a polyether ionophore antibiotic, is produced by Streptomyces cinnamonensis and worldwide used as a coccidiostat and growth-promoting agent in the field of animal feeding. The monensin biosynthetic gene cluster (mon) has been reported. In this study, the potential functions of three putatively pathway-specific regulators (MonH, MonRI, and MonRII) were clarified. The results from gene inactivation, complementation, and overexpression showed that MonH, MonRI, and MonRII positively regulate monensin production...
August 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28585859/evaluation-of-the-potential-for-drug-interactions-with-patiromer-in-healthy-volunteers
#10
Lawrence J Lesko, Elliot Offman, Christine Taylor Brew, Dahlia Garza, Wade Benton, Martha R Mayo, Alain Romero, Charles Du Mond, Matthew R Weir
INTRODUCTION: Patiromer is a potassium-binding polymer that is not systemically absorbed; however, it may bind coadministered oral drugs in the gastrointestinal tract, potentially reducing their absorption. METHODS: Twelve randomized, open-label, 3-period, 3-sequence crossover studies were conducted in healthy volunteers to evaluate the effect of patiromer (perpetrator drug) on absorption and single-dose pharmacokinetics (PK) of drugs (victims) that might be commonly used with patiromer...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28541768/sex-differences-in-the-presentation-of-body-dysmorphic-disorder-in-a-community-sample-of-adolescents
#11
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The current study sought to explore sex differences in the presentation of probable full-syndrome and subthreshold body dysmorphic disorder (BDD) in adolescents from an Australian community sample. Specifically, it examined sex differences in the types of BDD symptoms endorsed, body areas of concern, and the association with elevated symptoms of comorbid disorders. In male participants, it also compared the presenting features of those with and without muscle dysmorphia. Of 3,149 adolescents assessed using self-report questionnaires, 162 (5...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28488338/asymmetric-synthesis-of-%C3%AE-lactams-through-copper-catalyzed-alkyne-nitrone-coupling-with-a-prolinol-phosphine-chiral-ligand
#12
Yurie Takayama, Takaoki Ishii, Hirohisa Ohmiya, Tomohiro Iwai, Martin C Schwarzer, Seiji Mori, Tohru Taniguchi, Kenji Monde, Masaya Sawamura
Prolinol-phosphine chiral ligands enabled highly enantioselective copper-catalyzed intermolecular alkyne-nitrone coupling (Kinugasa reaction) to produce 1,3,4-trisubstituted chiral β-lactams. A high level of enantiocontrol was achieved not only with aryl- or alkenylacetylenes but also with alkylacetylenes, which were important but unfavorable substrates in the previously reported protocols. Two-point hydrogen bonding between the chiral ligand and the nitrone oxyanion consisting of O-H⋅⋅⋅O and C(sp(3) )-H⋅⋅⋅O hydrogen bonds is proposed...
May 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28487061/the-spectrum-of-ambulatory-electrocardiographic-monitoring
#13
REVIEW
Harry G Mond
Since its introduction as a clinical investigative tool, the 12-lead electrocardiograph (ECG) has been the gold standard for recognition of cardiac arrhythmias. The resting 12-lead ECG, however, gives only a rhythm snapshot in time, whereas arrhythmias maybe short-lived, paroxysmal and even asymptomatic making documentation in many patients very difficult. To overcome this, ambulatory ECG monitoring has been developed as a means of recording the ECG in patients over a set period of time, whether it be short-, medium- or long-term...
April 13, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28446240/molecular-mechanisms-by-which-herv-k-gag-interferes-with-hiv-1-gag-assembly-and-particle-infectivity
#14
Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda, Akira Ono
BACKGROUND: Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication. Indeed, previously we showed that HERV-K Gag and HIV-1 Gag coassemble and that this appears to correlate with the effect of HERV-K Gag expression on HIV-1 particle release and its infectivity. We further showed that coassembly requires both MA and NC domains, which presumably serve as scaffolding for Gag via their abilities to bind membrane and RNA, respectively...
April 26, 2017: Retrovirology
https://www.readbyqxmd.com/read/28441126/-message-du-pr%C3%A3-sident-nous-vivons-dans-un-monde-politis%C3%A3
#15
Tom Smith-Windsor
No abstract text is available yet for this article.
2017: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/28438139/digital-cxr-with-computer-aided-diagnosis-versus-symptom-screen-to-define-presumptive-tuberculosis-among-household-contacts-and-impact-on-tuberculosis-diagnosis
#16
Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya, Helen Ayles
BACKGROUND: Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However, this strategy may be limited due to poor performance in predicting TB. The objective of this study was to compare CXR with Computer Aided Diagnosis (CAD) against symptom screen for defining presumptive TB and how TB detection changes with each method. METHODS: Household contacts of consecutive index bacteriologically confirmed TB cases were visited by study teams and given TB/HIV education to raise awareness of the risk of TB following close contact with a TB patient...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28397989/formal-4-1-cycloaddition-and-enantioselective-michael-henry-cascade-reactions-to-synthesize-spiro-4-5-decanes-and-spirooxindole-polycycles
#17
Ji-Rong Huang, Muhammad Sohail, Tohru Taniguchi, Kenji Monde, Fujie Tanaka
Spiro[4,5]decanes and polycyclic compounds bearing spiro[4,5]decane systems are important biofunctional molecules. Described are diastereoselective formal (4+1) cycloaddition reactions to afford oxindole-functionalized spiro[4,5]decanes and organocatalytic enantioselective Michael-Henry cascade reactions of the (4+1) cycloaddition products to generate spirooxindole polycyclic derivatives bearing the spiro[4,5]decane system. Spiro[4,5]decanes bearing oxindoles containing three stereogenic centers and spirooxindole polycycles having seven stereogenic centers, including two all-carbon chiral quaternary centers and one tetrasubstituted chiral carbon center, were obtained with high diastereo- and enantioselectivities...
April 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28389062/sex-differences-in-quality-of-life-impairment-associated-with-body-dissatisfaction-in-adolescents
#18
Scott Griffiths, Stuart B Murray, Caroline Bentley, Kassandra Gratwick-Sarll, Carmel Harrison, Jonathan M Mond
PURPOSE: Body dissatisfaction is strongly associated with quality of life impairment among both male and female adults, and the strength of this relationship is comparable between the sexes. Whether this is the case among adolescents, however, is unclear. METHODS: Adolescent girls (n = 1,135) and boys (n = 531) aged 12-18 years were recruited from secondary schools located in the Australian Capital Territory, Australia. Students completed a survey that included measures of body dissatisfaction, eating disorder symptoms, and psychosocial health- and physical health-related quality of life...
March 25, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28267345/high-indexed-pt3ni-alloy-tetrahexahedral-nanoframes-evolved-through-preferential-co-etching
#19
Chenyu Wang, Lihua Zhang, Hongzhou Yang, Jinfong Pan, Jingyue Liu, Charles Dotse, Yiliang Luan, Rui Gao, Cuikun Lin, Jun Zhang, James P Kilcrease, Xiaodong Wen, Shouzhong Zou, Jiye Fang
Chemically controlling crystal structures in nanoscale is challenging, yet provides an effective way to improve catalytic performances. Pt-based nanoframes are a new class of nanomaterials that have great potential as high-performance catalysts. To date, these nanoframes are formed through acid etching in aqueous solutions, which demands long reaction time and often yields ill-defined surface structures. Herein we demonstrate a robust and unprecedented protocol for facile development of high-performance nanoframe catalysts using size and crystallographic facet-controlled PtNi4 tetrahexahedral nanocrystals prepared through a colloidal synthesis approach as precursors...
March 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28222723/rapid-precise-quantification-of-bacterial-cellular-dimensions-across-a-genomic-scale-knockout-library
#20
Tristan Ursell, Timothy K Lee, Daisuke Shiomi, Handuo Shi, Carolina Tropini, Russell D Monds, Alexandre Colavin, Gabriel Billings, Ilina Bhaya-Grossman, Michael Broxton, Bevan Emma Huang, Hironori Niki, Kerwyn Casey Huang
BACKGROUND: The determination and regulation of cell morphology are critical components of cell-cycle control, fitness, and development in both single-cell and multicellular organisms. Understanding how environmental factors, chemical perturbations, and genetic differences affect cell morphology requires precise, unbiased, and validated measurements of cell-shape features. RESULTS: Here we introduce two software packages, Morphometrics and BlurLab, that together enable automated, computationally efficient, unbiased identification of cells and morphological features...
February 21, 2017: BMC Biology
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