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https://www.readbyqxmd.com/read/29103935/deep-phenotypic-mapping-of-bacterial-cytoskeletal-mutants-reveals-physiological-robustness-to-cell-size
#1
Handuo Shi, Alexandre Colavin, Marty Bigos, Carolina Tropini, Russell D Monds, Kerwyn Casey Huang
Size is a universally defining characteristic of all living cells and tissues and is intrinsically linked with cell genotype, growth, and physiology. Many mutations have been identified to alter cell size, but pleiotropic effects have largely hampered our ability to probe how cell size specifically affects fundamental cellular properties, such as DNA content and intracellular localization. To systematically interrogate the impact of cell morphology on bacterial physiology, we used fluorescence-activated cell sorting to enrich a library of hundreds of Escherichia coli mutants in the essential cytoskeletal protein MreB for subtle changes in cell shape, cumulatively spanning ∼5-fold variation in average cell volume...
November 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29094603/psychometric-properties-of-the-eating-disorder-examination-questionnaire-ede-q-a-confirmatory-factor-analysis-and-assessment-of-measurement-invariance-by-sex
#2
Devin Rand-Giovannetti, David C Cicero, Jonathan M Mond, Janet D Latner
The original, theoretically derived factor structure of the Eating Disorder Examination-Questionnaire (EDE-Q) has received limited empirical support and there is no consensus on an appropriate alternative. Moreover, there is a paucity of data on the factor structure of the EDE-Q across sexes. The goals of the current study were to evaluate models of the EDE-Q factor structure and to assess the best-fitting model for differences by sex. Twelve models were compared using confirmatory factor analysis in a sample of 940 undergraduates...
November 1, 2017: Assessment
https://www.readbyqxmd.com/read/29076380/body-size-and-shape-misperception-and-visual-adaptation-an-overview-of-an-emerging-research-paradigm
#3
Kirsten L Challinor, Jonathan Mond, Ian D Stephen, Deborah Mitchison, Richard J Stevenson, Phillipa Hay, Kevin R Brooks
Although body size and shape misperception (BSSM) is a common feature of anorexia nervosa, bulimia nervosa and muscle dysmorphia, little is known about its underlying neural mechanisms. Recently, a new approach has emerged, based on the long-established non-invasive technique of perceptual adaptation, which allows for inferences about the structure of the neural apparatus responsible for alterations in visual appearance. Here, we describe several recent experimental examples of BSSM, wherein exposure to "extreme" body stimuli causes visual aftereffects of biased perception...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29035131/ri-002-an-intravenous-immunoglobulin-containing-high-titer-neutralizing-antibody-to-rsv-and-other-respiratory-viruses-for-use-in-primary-immunodeficiency-disease-and-other-immune-compromised-populations
#4
Richard L Wasserman, Benjamin N Greener, James Mond
Novel immune globulin (IG) products (RI-002, RI-001) have been designed to provide protection against respiratory syncytial virus (RSV) mediated respiratory illness while at the same time meeting the manufacturing requirements established by FDA for antibody supplementation in immunocompromised subjects. Areas covered: This review covers the manufacture and development of both RI-001 and RI-002, including the selection of plasma donors for IG preparation with high-titers of anti-RSV antibody, in vitro, and preclinical data in the cotton rat model S...
October 16, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29032788/using-the-bergman-paris-question-to-screen-seniors-in-the-emergency-department
#5
Antoine Lague, Philippe Voyer, Marie-Christine Ouellet, Vale Rie Boucher, Marianne Giroux, Mathieu Pelletier, E Milie Gouin, Raoul Daoust, Simon Berthelot, Miche le Morin, Thien Tuong Minh Vu, Jacques Lee, Audrey-Anne Brousseau, Marie-Jose E Sirois, Marcel E Mond
OBJECTIVES: In the fast pace of the Emergency Department (ED), clinicians are in need of tailored screening tools to detect seniors who are at risk of adverse outcomes. We aimed to explore the usefulness of the Bergman-Paris Question (BPQ) to expose potential undetected geriatric syndromes in community-living seniors presenting to the ED. METHODS: This is a planned sub-study of the INDEED multicentre prospective cohort study, including independent or semi-independent seniors (≥65 years old) admitted to hospital after an ED stay ≥8 hours and who were not delirious...
October 16, 2017: CJEM
https://www.readbyqxmd.com/read/29019298/a-learned-artisan-debates-the-system-of-the-world-le-clerc-versus-mallemant-de-messange
#6
Oded Rabinovitch
Sébastien Le Clerc (1637-1714) was the most renowned engraver of Louis XIV's France. For the history of scientific publishing, however, Le Clerc represents a telling paradox. Even though he followed a traditional route based on classic artisanal training, he also published extensively on scientific topics such as cosmology and mathematics. While contemporary scholarship usually stresses the importance of artisanal writing as a direct expression of artisanal experience and know-how, Le Clerc's publications, and specifically the work on cosmology in his Système du monde (1706-1708), go far beyond this...
October 11, 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28992343/serum-to-dialysate-potassium-gradient-and-its-association-with-short-term-outcomes-in-hemodialysis-patients
#7
Steven M Brunelli, David M Spiegel, Charles Du Mond, Nina Oestreicher, Wolfgang C Winkelmayer, Csaba P Kovesdy
Background: A high serum-to-dialysate potassium (K + ) gradient at the start of dialysis leads to rapid lowering of serum K + and may confer a greater risk of adverse events. Here, we examined the near-term association of K + gradient with clinical outcomes. Methods: This retrospective (2010-11) event-based study considered 830 741 patient-intervals, each defined by a pre-dialysis measurement of serum K + made among adult Medicare Parts A and B enrollees who received in-center hemodialysis on a Monday/Wednesday/Friday schedule at a large US dialysis organization...
August 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28943890/erratum-to-the-mental-health-and-help-seeking-behaviour-of-resettled-afghan-refugees-in-australia
#8
Shameran Slewa-Younan, Anisa Yaser, Maria Gabriela Uribe Guajardo, Haider Mannan, Caroline A Smith, Jonathan M Mond
[This corrects the article DOI: 10.1186/s13033-017-0157-z.].
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28925911/-message-du-pr%C3%A3-sident-un-monde-meilleur
#9
Tom Smith-Windsor
No abstract text is available yet for this article.
2017: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/28891676/pornography-use-in-sexual-minority-males-associations-with-body-dissatisfaction-eating-disorder-symptoms-thoughts-about-using-anabolic-steroids-and-quality-of-life
#10
Scott Griffiths, Deborah Mitchison, Stuart B Murray, Jonathan M Mond
OBJECTIVE: We examined two hypotheses regarding the potential association of pornography use with body image-related and eating disorder-related psychopathology among sexual minority males (i.e. non-heterosexual males). Our primary hypothesis was that pornography use would be associated with males' body dissatisfaction, eating disorder symptoms, thoughts about using anabolic steroids and quality of life impairment; our secondary hypothesis was that the type of pornography, namely, professional versus amateur pornography, which contains idealised and non-idealised (i...
September 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28858657/the-classification-of-body-dysmorphic-disorder-symptoms-in-male-and-female-adolescents
#11
Sophie C Schneider, Andrew J Baillie, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
BACKGROUND: Body dysmorphic disorder (BDD) was categorised in DSM-5 within the newly created 'obsessive-compulsive and related disorders' chapter, however this classification remains subject to debate. Confirmatory factor analysis was used to test competing models of the co-occurrence of symptoms of BDD, obsessive-compulsive disorder, unipolar depression, anxiety, and eating disorders in a community sample of adolescents, and to explore potential sex differences in these models. METHODS: Self-report questionnaires assessing disorder symptoms were completed by 3149 Australian adolescents...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28855961/the-mental-health-and-help-seeking-behaviour-of-resettled-afghan-refugees-in-australia
#12
Shameran Slewa-Younan, Anisa Yaser, Maria Gabriela Uribe Guajardo, Haider Mannan, Caroline A Smith, Jonathan M Mond
BACKGROUND: Psychological trauma, in particular, posttraumatic stress disorder (PTSD) and depression, are highly prevalent among resettled refugees. However, little is known regarding the mental health status and associated help-seeking behaviour of resettled Afghan refugees in Australia. METHODS: A sample of 150 resettled Afghan refugees (74 males; mean age 32.8 years, SD = 12.2) living in Adelaide, South Australia were recruited. Self-reported measures of PTSD, depression, exposure to traumatic events, functional impairment, self-recognition of PTSD symptomatology and help-seeking behaviours were completed...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28836352/early-intervention-for-bipolar-disorder-in-adolescents-a-psychosocial-perspective
#13
REVIEW
Claire McAulay, Jonathan Mond, Stephen Touyz
AIM: Early intervention in bipolar disorder (BD) has received increasing attention in recent years. The identification of risk factors has improved, but researchers continue to struggle to find an effective treatment once the illness has become established. The aetiology of BD and feasibility of early intervention present a challenge, making it difficult to decide who to target, as well as how. METHODS: This essay seeks to address the lack of guidance for managing patients with a possible emerging bipolar illness, by presenting a rough roadmap to psychological care...
August 23, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28827668/a-clue-to-unprecedented-strategy-to-hiv-eradication-lock-in-and-apoptosis
#14
Hiroshi Tateishi, Kazuaki Monde, Kensaku Anraku, Ryoko Koga, Yuya Hayashi, Halil Ibrahim Ciftci, Hasan DeMirci, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Masami Otsuka, Mikako Fujita
Despite the development of antiretroviral therapy against HIV, eradication of the virus from the body, as a means to a cure, remains in progress. A "kick and kill" strategy proposes "kick" of the latent HIV to an active HIV to eventually be "killed". Latency-reverting agents that can perform the "kick" function are under development and have shown promise. Management of the infected cells not to produce virions after the "kick" step is important to this strategy. Here we show that a newly synthesized compound, L-HIPPO, captures the HIV-1 protein Pr55(Gag) and intercepts its function to translocate the virus from the cytoplasm to the plasma membrane leading to virion budding...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819689/beware-of-the-coronary-arteries-with-implantable-cardiac-electronic-devices
#15
REVIEW
S Serge Barold, Benjamin J Pang, Harry G Mond
The transvenous implantation of cardiac devices may sometimes cause serious complications involving the coronary arteries. The left anterior descending artery may be injured during nonapical right ventricular implantation while a right atrial lead may injure the right or circumflex coronary artery. Injury of a left internal mammary graft to a coronary artery may cause myocardial infarction.
September 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28808279/fine-tuning-and-mond-in-a-metamaterial-multiverse
#16
Igor I Smolyaninov, Vera N Smolyaninova
We consider the recently suggested model of a multiverse based on a ferrofluid. When the ferrofluid is subjected to a modest external magnetic field, the nanoparticles inside the ferrofluid form small hyperbolic metamaterial domains, which from the electromagnetic standpoint behave as individual "Minkowski universes" exhibiting different "laws of physics", such as different strength of effective gravity, different versions of modified Newtonian dynamics (MOND) and different radiation lifetimes. When the ferrofluid "multiverse" is populated with atomic or molecular species, and these species are excited using an external laser source, the radiation lifetimes of atoms and molecules in these "universes" depend strongly on the individual physical properties of each "universe" via the Purcell effect...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800416/the-enigma-of-male-eating-disorders-a-critical-review-and-synthesis
#17
REVIEW
Stuart B Murray, Jason M Nagata, Scott Griffiths, Jerel P Calzo, Tiffany A Brown, Deborah Mitchison, Aaron J Blashill, Jonathan M Mond
Historically, male presentations of eating disorders (EDs) have been perceived as rare and atypical - a perception that has resulted in the systematic underrepresentation of males in ED research. This underrepresentation has profoundly impacted clinical practice with male patients, in which i) stigmatization and treatment non-engagement are more likely, ii) a distinct array of medical complexities are faced, and iii) symptom presentations differ markedly from female presentations. Further, the marginalization of males from ED research has hindered the assessment and clinical management of these presentations...
November 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28797070/methyl-pyruvate-protects-a-normal-lung-fibroblast-cell-line-from-irinotecan-induced-cell-death-potential-use-as-adjunctive-to-chemotherapy
#18
Bernice Monchusi, Monde Ntwasa
The Warburg Effect, characterized by increased rate of glycolysis even under normoxic conditions, is one of the hallmarks of cancer. Relatively lower oxidative phosphorylation (OXPHOS) is also a characteristic feature in cancer cells. We hypothesized that interference with this phenomenon, by introducing exogenous pyruvate, would upset this cancer phenotype and boost the energy requirements of normal cells. We find that methyl pyruvate protects irinotecan-treated normal lung fibroblast cell line (MRC-5) probably by turning off the p53/p21 axis of the apoptotic pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28796461/ce-que-peut-la-sociologie
#19
Bernard Lahire
When it is relational, processual, and it articulates the incorporated dispositions of the actors and the contexts of their actions, sociology "desevidentialize," denaturalize, desubstantialize, and historicize the social world by contributing to do away with spontaneous representations that distort the reality of things. Besides, when sociology studies the social at the level of the individuals and individual actions, it destroys the fictions (juridical and philosophical) of the isolated individuals, enclosed on himself, free and fully conscious of everything...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28796452/in-praise-of-sociology
#20
Raewyn Connell
This reflection on the relevance of sociology starts with the different forms of social knowledge, and some autobiographical reflection on my engagement with the discipline. A research-based social science is made urgent by the prevalence of distortion and pseudoscience in the public realm. However, the research-based knowledge formation is embedded in a global economy of knowledge that centers on a privileged group of institutions and produces major imbalances on a world scale. Sociological data collection has important uses in policy and public discussion...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
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