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https://www.readbyqxmd.com/read/28685195/characterization-of-three-pathway-specific-regulators-for-high-production-of-monensin-in-streptomyces-cinnamonensis
#1
Zheng-Kun Tang, Xiao-Mei Li, Ai-Ping Pang, Chun-Yan Lin, Yue Zhang, Jie Zhang, Jianjun Qiao, Guang-Rong Zhao
Monensin, a polyether ionophore antibiotic, is produced by Streptomyces cinnamonensis and worldwide used as a coccidiostat and growth-promoting agent in the field of animal feeding. The monensin biosynthetic gene cluster (mon) has been reported. In this study, the potential functions of three putatively pathway-specific regulators (MonH, MonRI, and MonRII) were clarified. The results from gene inactivation, complementation, and overexpression showed that MonH, MonRI, and MonRII positively regulate monensin production...
July 7, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28585859/evaluation-of-the-potential-for-drug-interactions-with-patiromer-in-healthy-volunteers
#2
Lawrence J Lesko, Elliot Offman, Christine Taylor Brew, Dahlia Garza, Wade Benton, Martha R Mayo, Alain Romero, Charles Du Mond, Matthew R Weir
INTRODUCTION: Patiromer is a potassium-binding polymer that is not systemically absorbed; however, it may bind coadministered oral drugs in the gastrointestinal tract, potentially reducing their absorption. METHODS: Twelve randomized, open-label, 3-period, 3-sequence crossover studies were conducted in healthy volunteers to evaluate the effect of patiromer (perpetrator drug) on absorption and single-dose pharmacokinetics (PK) of drugs (victims) that might be commonly used with patiromer...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28541768/sex-differences-in-the-presentation-of-body-dysmorphic-disorder-in-a-community-sample-of-adolescents
#3
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The current study sought to explore sex differences in the presentation of probable full-syndrome and subthreshold body dysmorphic disorder (BDD) in adolescents from an Australian community sample. Specifically, it examined sex differences in the types of BDD symptoms endorsed, body areas of concern, and the association with elevated symptoms of comorbid disorders. In male participants, it also compared the presenting features of those with and without muscle dysmorphia. Of 3,149 adolescents assessed using self-report questionnaires, 162 (5...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28488338/asymmetric-synthesis-of-%C3%AE-lactams-through-copper-catalyzed-alkyne-nitrone-coupling-with-a-prolinol-phosphine-chiral-ligand
#4
Yurie Takayama, Takaoki Ishii, Hirohisa Ohmiya, Tomohiro Iwai, Martin C Schwarzer, Seiji Mori, Tohru Taniguchi, Kenji Monde, Masaya Sawamura
Prolinol-phosphine chiral ligands enabled highly enantioselective copper-catalyzed intermolecular alkyne-nitrone coupling (Kinugasa reaction) to produce 1,3,4-trisubstituted chiral β-lactams. A high level of enantiocontrol was achieved not only with aryl- or alkenylacetylenes but also with alkylacetylenes, which were important but unfavorable substrates in the previously reported protocols. Two-point hydrogen bonding between the chiral ligand and the nitrone oxyanion consisting of O-H⋅⋅⋅O and C(sp(3) )-H⋅⋅⋅O hydrogen bonds is proposed...
May 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28487061/the-spectrum-of-ambulatory-electrocardiographic-monitoring
#5
REVIEW
Harry G Mond
Since its introduction as a clinical investigative tool, the 12-lead electrocardiograph (ECG) has been the gold standard for recognition of cardiac arrhythmias. The resting 12-lead ECG, however, gives only a rhythm snapshot in time, whereas arrhythmias maybe short-lived, paroxysmal and even asymptomatic making documentation in many patients very difficult. To overcome this, ambulatory ECG monitoring has been developed as a means of recording the ECG in patients over a set period of time, whether it be short-, medium- or long-term...
April 13, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28446240/molecular-mechanisms-by-which-herv-k-gag-interferes-with-hiv-1-gag-assembly-and-particle-infectivity
#6
Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda, Akira Ono
BACKGROUND: Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication. Indeed, previously we showed that HERV-K Gag and HIV-1 Gag coassemble and that this appears to correlate with the effect of HERV-K Gag expression on HIV-1 particle release and its infectivity. We further showed that coassembly requires both MA and NC domains, which presumably serve as scaffolding for Gag via their abilities to bind membrane and RNA, respectively...
April 26, 2017: Retrovirology
https://www.readbyqxmd.com/read/28441126/-message-du-pr%C3%A3-sident-nous-vivons-dans-un-monde-politis%C3%A3
#7
Tom Smith-Windsor
No abstract text is available yet for this article.
2017: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/28438139/digital-cxr-with-computer-aided-diagnosis-versus-symptom-screen-to-define-presumptive-tuberculosis-among-household-contacts-and-impact-on-tuberculosis-diagnosis
#8
Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya, Helen Ayles
BACKGROUND: Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However, this strategy may be limited due to poor performance in predicting TB. The objective of this study was to compare CXR with Computer Aided Diagnosis (CAD) against symptom screen for defining presumptive TB and how TB detection changes with each method. METHODS: Household contacts of consecutive index bacteriologically confirmed TB cases were visited by study teams and given TB/HIV education to raise awareness of the risk of TB following close contact with a TB patient...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28397989/formal-4-1-cycloaddition-and-enantioselective-michael-henry-cascade-reactions-to-synthesize-spiro-4-5-decanes-and-spirooxindole-polycycles
#9
Ji-Rong Huang, Muhammad Sohail, Tohru Taniguchi, Kenji Monde, Fujie Tanaka
Spiro[4,5]decanes and polycyclic compounds bearing spiro[4,5]decane systems are important biofunctional molecules. Described are diastereoselective formal (4+1) cycloaddition reactions to afford oxindole-functionalized spiro[4,5]decanes and organocatalytic enantioselective Michael-Henry cascade reactions of the (4+1) cycloaddition products to generate spirooxindole polycyclic derivatives bearing the spiro[4,5]decane system. Spiro[4,5]decanes bearing oxindoles containing three stereogenic centers and spirooxindole polycycles having seven stereogenic centers, including two all-carbon chiral quaternary centers and one tetrasubstituted chiral carbon center, were obtained with high diastereo- and enantioselectivities...
April 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28389062/sex-differences-in-quality-of-life-impairment-associated-with-body-dissatisfaction-in-adolescents
#10
Scott Griffiths, Stuart B Murray, Caroline Bentley, Kassandra Gratwick-Sarll, Carmel Harrison, Jonathan M Mond
PURPOSE: Body dissatisfaction is strongly associated with quality of life impairment among both male and female adults, and the strength of this relationship is comparable between the sexes. Whether this is the case among adolescents, however, is unclear. METHODS: Adolescent girls (n = 1,135) and boys (n = 531) aged 12-18 years were recruited from secondary schools located in the Australian Capital Territory, Australia. Students completed a survey that included measures of body dissatisfaction, eating disorder symptoms, and psychosocial health- and physical health-related quality of life...
March 25, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28267345/high-indexed-pt3ni-alloy-tetrahexahedral-nanoframes-evolved-through-preferential-co-etching
#11
Chenyu Wang, Lihua Zhang, Hongzhou Yang, Jinfong Pan, Jingyue Liu, Charles Dotse, Yiliang Luan, Rui Gao, Cuikun Lin, Jun Zhang, James P Kilcrease, Xiaodong Wen, Shouzhong Zou, Jiye Fang
Chemically controlling crystal structures in nanoscale is challenging, yet provides an effective way to improve catalytic performances. Pt-based nanoframes are a new class of nanomaterials that have great potential as high-performance catalysts. To date, these nanoframes are formed through acid etching in aqueous solutions, which demands long reaction time and often yields ill-defined surface structures. Herein we demonstrate a robust and unprecedented protocol for facile development of high-performance nanoframe catalysts using size and crystallographic facet-controlled PtNi4 tetrahexahedral nanocrystals prepared through a colloidal synthesis approach as precursors...
March 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28222723/rapid-precise-quantification-of-bacterial-cellular-dimensions-across-a-genomic-scale-knockout-library
#12
Tristan Ursell, Timothy K Lee, Daisuke Shiomi, Handuo Shi, Carolina Tropini, Russell D Monds, Alexandre Colavin, Gabriel Billings, Ilina Bhaya-Grossman, Michael Broxton, Bevan Emma Huang, Hironori Niki, Kerwyn Casey Huang
BACKGROUND: The determination and regulation of cell morphology are critical components of cell-cycle control, fitness, and development in both single-cell and multicellular organisms. Understanding how environmental factors, chemical perturbations, and genetic differences affect cell morphology requires precise, unbiased, and validated measurements of cell-shape features. RESULTS: Here we introduce two software packages, Morphometrics and BlurLab, that together enable automated, computationally efficient, unbiased identification of cells and morphological features...
February 21, 2017: BMC Biology
https://www.readbyqxmd.com/read/28199910/subthreshold-body-dysmorphic-disorder-in-adolescents-prevalence-and-impact
#13
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The aim of the current study was to establish the prevalence of subthreshold body dysmorphic disorder (subthreshold-BDD) in a community sample of adolescents, and to compare disorder correlates in individuals with subthreshold-BDD to those with probable full-syndrome BDD (probable-BDD) and those without BDD (non-BDD). Self-report questionnaires assessing DSM-IV BDD criteria, past mental health service use, and symptoms of body dysmorphic disorder, anxiety, depression, obsessive-compulsive disorder and eating disorders, were completed by 3149 Australian high school students (mean age =14...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28159034/food-insecurity-and-health-status-in-deprived-populations-2014-a-multicentre-survey-in-seven-of-the-social-and-medical-healthcare-centres-casos-run-by-doctors-of-the-world-france
#14
MULTICENTER STUDY
S Laurence, E Durand, E Thomas, M Chappuis, J F Corty
OBJECTIVE: To document eating practices and socio-economic profiles of patients seen in the social and medical healthcare centres (CASOs in its French acronym) run by Doctors of the World (Médecins du Monde, MdM) in France and evaluate their nutritional and health status. STUDY DESIGN: The survey was carried out between April and May 2014 in seven CASOs in France. METHODS: All the patients attending MdM clinics were given a nutrition and health questionnaire...
February 2017: Public Health
https://www.readbyqxmd.com/read/28155303/female-perspectives-of-male-partners-inclusion-in-the-prevention-of-mother-to-child-hiv-transmission-programme-in-kwazulu-natal
#15
Mondli Miya, Tennyson Mgutshini
BACKGROUND: The South African government intervened by implementing the prevention of mother-to-child transmission programme (PMTCT) to curb the HIV transmission from mother to child during and after pregnancy. The PMTCT programme has been at the forefront of global prevention efforts since 1998. Without treatment, the risk of transmission ranges from one in five to one in two newborns; however, the risk of mother-to-child transmission can be reduced to as low as 2%-5% with evidenced interventions...
December 7, 2016: Curationis
https://www.readbyqxmd.com/read/28143626/cognition-and-adaptive-functioning-in-older-people-attending-drug-and-alcohol-services
#16
L A Monds, N J Ridley, C Rivas, A Withall, B Draper, N Lintzeris
BACKGROUND: Substance use disorders in older adults are expected to increase dramatically in the coming years. Given the increased susceptibility to cognitive deficits in older substance users (defined here as aged 50+ years due to the accelerated health decline observed in this population), it is important to consider the functional correlates of cognitive impairment in these older adults. This study details the cognitive status of older individuals attending outpatient drug and alcohol (D&A) treatment services and seeks to determine of the association of cognitive impairment to self-reported daily functioning...
February 1, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28111027/serum-potassium-and-short-term-clinical-outcomes-among-hemodialysis-patients-impact-of-the-long-interdialytic-interval
#17
Steven M Brunelli, Charles Du Mond, Nina Oestreicher, Viatcheslav Rakov, David M Spiegel
BACKGROUND: Hyperkalemia is common among hemodialysis patients and is associated with morbidity and mortality. The long interdialytic interval is likewise associated with adverse outcomes. However, the interplay among serum potassium, dialysis cycle phase, and clinical outcomes has not been examined. STUDY DESIGN: Retrospective observational study. SETTING & PARTICIPANTS: 52,734 patients receiving in-center hemodialysis at a large dialysis organization during 2010 and 2011 contributed 533,889 potassium measurements (230,634 on Monday; 285,522 on Wednesday; 17,733 on Friday)...
July 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28075492/a-thematic-content-analysis-of-cheatmeal-images-on-social-media-characterizing-an-emerging-dietary-trend
#18
Eva Pila, Jonathan M Mond, Scott Griffiths, Deborah Mitchison, Stuart B Murray
Despite the pervasive social endorsement of "cheat meals" within pro-muscularity online communities, there is an absence of empirical work examining this dietary phenomenon. The present study aimed to characterize cheat meals, and explore the meaning ascribed to engagement in this practice. Thematic content analysis was employed to code the photographic and textual elements of a sample (n = 600) that was extracted from over 1.6 million images marked with the #cheatmeal tag on the social networking site, Instagram...
January 11, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28071712/independent-aftereffects-of-fat-and-muscle-implications-for-neural-encoding-body-space-representation-and-body-image-disturbance
#19
Daniel Sturman, Ian D Stephen, Jonathan Mond, Richard J Stevenson, Kevin R Brooks
Although research addressing body size misperception has focused on socio-cognitive processes, such as internalization of the "ideal" images of bodies in the media, the perceptual basis of this phenomenon remains largely unknown. Further, most studies focus on body size per se even though this depends on both fat and muscle mass - variables that have very different relationships with health. We tested visual adaptation as a mechanism for inducing body fat and muscle mass misperception, and assessed whether these two dimensions of body space are processed independently...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053660/causes-of-and-risk-factors-for-posttraumatic-stress-disorder-the-beliefs-of-iraqi-and-afghan-refugees-resettled-in-australia
#20
Shameran Slewa-Younan, Maria Gabriela Uribe Guajardo, Anisa Yaser, Jonathan Mond, Mitchell Smith, Diana Milosevic, Caroline Smith, Sanja Lujic, Anthony Francis Jorm
BACKGROUND: Resettled refugees are a vulnerable group for mental health problems and in particular, trauma-related disorders. Evidence suggests that poor 'mental health literacy' (MHL) is a major factor in low or inappropriate treatment-seeking among individuals with mental health problems. This study sought to determine the beliefs regarding the causes of and risk factors for post-traumatic stress disorder (PTSD) amongst two resettled refugee groups in Australia. METHODS: Utilising a culturally adapted MHL survey method, 225 Iraqis and 150 Afghans of refugee background were surveyed...
2017: International Journal of Mental Health Systems
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