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Javiera Bahamonde, Bonnie Brenseke, Matthew Y Chan, Ronald D Kent, Peter J Vikesland, M Renee Prater
Nanotoxicity studies are greatly needed to advance nanomedical technologies into clinical practice. We assessed the toxic effects of a single intravenous exposure to commercially available gold nanoparticles (GNPs) in mice and rats. Fifteen-nm GNPs were purchased and independently characterized. Animals were exposed to either 1,000 mg GNPs/kg body weight (GNP group) or phosphate-buffered saline. Subsets of animals were euthanized and samples collected at 1, 7, 14, 21, and 28 days postexposure. Independent characterization demonstrated that the physicochemical properties of the purchased GNPs were in good agreement with the information provided by the supplier...
January 1, 2018: Toxicologic Pathology
Sonja Mülhopt, Silvia Diabaté, Marco Dilger, Christel Adelhelm, Christopher Anderlohr, Thomas Bergfeldt, Johan Gómez de la Torre, Yunhong Jiang, Eugenia Valsami-Jones, Dominique Langevin, Iseult Lynch, Eugene Mahon, Inge Nelissen, Jordi Piella, Victor Puntes, Sikha Ray, Reinhard Schneider, Terry Wilkins, Carsten Weiss, Hanns-Rudolf Paur
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs...
May 8, 2018: Nanomaterials
Jens Balke, Pierre Volz, Falko Neumann, Robert Brodwolf, Alexander Wolf, Hannah Pischon, Moritz Radbruch, Lars Mundhenk, Achim D Gruber, Nan Ma, Ulrike Alexiev
Nanoparticles hold a great promise in biomedical science. However, due to their unique physical and chemical properties they can lead to overproduction of intracellular reactive oxygen species (ROS). As an important mechanism of nanotoxicity, there is a great need for sensitive and high-throughput adaptable single-cell ROS detection methods. Here, fluorescence lifetime imaging microscopy (FLIM) is employed for single-cell ROS detection (FLIM-ROX) providing increased sensitivity and enabling high-throughput analysis in fixed and live cells...
May 4, 2018: Small
Younes Bouallegui, Ridha Ben Younes, Ridha Oueslati, David Sheehan
Oxidative stress is often implicated in nanoparticle toxicity. Several studies have highlighted the role of internalization routes in determining nanotoxicity. Here, we investigate how two endocytotic mechanisms (clathrin- and caveolae-mediated) impact on redox balance in gill and digestive gland of the mussel, Mytilus galloprovincialis. Animals were exposed (for 3, 6 and 12 h) to two sizes of silver nanoparticles (AgNP: <50 nm and <100 nm) prior to and after blockade of two endocytic pathways (amantadine blocks clathrin-mediated endocytosis while nystatin blocks caveolae-mediated endocytosis)...
April 23, 2018: Aquatic Toxicology
Daniela E Igartúa, Carolina S Martinez, C Facundo Temprana, Silvia Del V Alonso, M Jimena Prieto
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient pharmacokinetic profiles, and multiple side effects. PAMAM dendrimers, ethylenediamine core, generation 4.0 (amine terminal groups) and 4.5 (carboxylate terminal groups) (DG4.0 and DG4.5 respectively) are polymers that can increase drug solubility through complexation. Thus, the aim of this work was to obtain and characterize complexes between CBZ and dendrimers...
April 17, 2018: International Journal of Pharmaceutics
Shannon K Hanna, Antonio R Montoro Bustos, Alexander W Peterson, Vytas Reipa, Leona D Scanlan, Sanem Hosbas Coskun, Tae Joon Cho, Monique E Johnson, Vincent A Hackley, Bryant C Nelson, Michael R Winchester, John T Elliott, Elijah J Petersen
The increased use and incorporation of engineered nanoparticles (ENPs) in consumer products requires a robust assessment of their potential environmental implications. However, a lack of standardized methods for nanotoxicity testing has yielded results that are sometimes contradictory. Standard ecotoxicity assays may work appropriately for some ENPs with minimal modification, but produce artifactual results for others. Therefore, understanding the robustness of assays for a range of ENPs is critical. In this study, we evaluated the performance of a standard Caenorhabditis elegans (C...
April 19, 2018: Environmental Science & Technology
Lorena M Cucci, Alessia Munzone, Irina Naletova, Antonio Magrì, Diego La Mendola, Cristina Satriano
Angiogenin is a protein crucial in angiogenesis, and it is overexpressed in many cancers and downregulated in neurodegenerative diseases, respectively. The protein interaction with actin, through the loop encompassing the 60-68 residues, is an essential step in the cellular cytoskeleton reorganization. This, in turn, influences the cell proliferation and migration processes. In this work, hybrid nanoassemblies of gold nanoparticles with angiogenin fragments containing the 60-68 sequence were prepared and characterized in their interaction with both model membranes of supported lipid bilayers (SLBs) and cellular membranes of cancer (neuroblastoma) and normal (fibroblasts) cell lines...
April 16, 2018: Biointerphases
Jinchang Yin, Deqi Chen, Yu Zhang, Chaorui Li, Lizhi Liu, Yuanzhi Shao
Gadolinium oxide-based core-shelled nanoparticles have recently emerged as novel magnetic resonance imaging contrast agents for high relaxivity and tumor targeting. However, their relaxivity enhancement mechanism has not yet been clearly understood. We prepared highly dispersible and uniform core-shell structured nanoparticles by encapsulating silica spheres (90 nm in diameter) with gadolinium oxide shells of different thicknesses (from 1.5 nm to 20 nm), and proved experimentally that the shell thickness has an inverse effect on relaxivity...
April 5, 2018: Physical Chemistry Chemical Physics: PCCP
Titas Kumar Mukhopadhyay, Kalishankar Bhattacharyya, Ayan Datta
Recent toxicological assessments of graphene, graphene oxides and some other 2D materials have shown them to be substantially toxic at the nanoscale where they inhibit and eventually disrupt biological processes. These shortfalls of graphene and analogs have resulted in a quest for novel biocompatible two dimensional materials with minimum cytotoxicity. In this article, we demonstrate C2N (h2D-C2N), a newly synthesized two dimensional porous graphene analog to be non - nanotoxic towards genetic materials from an "in - silico" point of view through sequence dependent binding of different polynucleotide single stranded DNA onto it...
April 3, 2018: ACS Applied Materials & Interfaces
Merethe Kleiven, Lisa M Rossbach, Julian A Gallego-Urrea, Dag Anders Brede, Deborah H Oughton, Claire Coutris
Using Caenorhabditis elegans as a model organism, this study addresses the potential linkage between toxicity of NM300K Ag nanoparticles (AgNPs), their particle size distribution and the presence of dissolved Ag in the test media. Of the three endpoints assessed (growth, fertility and reproduction), reproduction was the most sensitive, with 50% effect concentration (EC50) ranging from 0.26-0.84 mg Ag L-1 and 0.08-0.11 mg Ag L-1 for NM300K and AgNO3 , respectively. Silver uptake by C. elegans was similar for both forms of Ag, while bioaccumulation was higher in AgNO3 exposure...
March 31, 2018: Environmental Toxicology and Chemistry
Naihao Lu, Yinhua Sui, Yun Ding, Rong Tian, Li Li, Fufeng Liu
With the potential uses of carbon nanotubes (CNTs) in biomedical and biotechnological applications, and the growing concerns about nanotoxicity of these engineered nanoparticles, the importance of protein-nanoparticle interaction has not been well stressed. In this study, we used both experimental and theoretical approaches to investigate the interactions of different functionalized single-walled CNTs (SWCNTs) with human serum albumin (HSA). It was found that the HSA adsorption capacities of CNTs followed the order carboxylated SWCNTs > hydroxylated SWCNTs > amined SWCNTs...
March 27, 2018: Chemico-biological Interactions
Chuanxin Ma, Jason C White, Jian Zhao, Qing Zhao, Baoshan Xing
With the rapidly increasing demand for and use of engineered nanoparticles (NPs) in agriculture and related sectors, concerns over the risks to agricultural systems and to crop safety have been the focus of a number of investigations. Significant evidence exists for NP accumulation in soils, including potential particle transformation in the rhizosphere and within terrestrial plants, resulting in subsequent uptake by plants that can yield physiological deficits and molecular alterations that directly undermine crop quality and food safety...
March 25, 2018: Annual Review of Food Science and Technology
Mandy Hei Man Leung, Amy Q Shen
The ability to control particle size and size distribution of nanoparticles for drug delivery is essential because it impacts on the biodistribution and cellular uptake of nanoparticles. We present a novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70nm) and narrow particle size distribution (polydispersity index less than 0.2). Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin...
March 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Bo Zhang, Mouzhe Xie, Lei Bruschweiler-Li, Rafael Brüschweiler
Understanding and harnessing the interactions between nanoparticles and biological molecules is at the forefront of applications of nanotechnology to modern biology. Metabolomics has emerged as a prominent player in systems biology as a complement to genomics, transcriptomics and proteomics. Its focus is the systematic study of metabolite identities and concentration changes in living systems. Despite significant progress over the recent past, important challenges in metabolomics remain, such as the deconvolution of the spectra of complex mixtures with strong overlaps, the sensitive detection of metabolites at low abundance, unambiguous identification of known metabolites, structure determination of unknown metabolites and standardized sample preparation for quantitative comparisons...
March 13, 2018: Metabolites
Alex J Sposito, Aditya Kurdekar, Jiangqin Zhao, Indira Hewlett
Rapid detection and identification of pathogenic microorganisms is fundamental to minimizing the spread of infectious disease, and informing clinicians on patient treatment strategies. This need has led to the development of enhanced biosensors that utilize state of the art nanomaterials and nanotechnology, and represent the next generation of diagnostics. A primer on nanoscale biorecognition elements such as, nucleic acids, antibodies, and their synthetic analogs (molecular imprinted polymers), will be presented first...
March 12, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Shih-Ming Tsai, Edith Duran-Robles, Tyler Goshia, Maria Mesina, Carlos Garcia, Julia Young, Angelo Sibal, Meng-Hsuen Chiu, Wei-Chun Chin
Nanotoxicity studies associated with various nanoparticles (NPs) have attracted intense research interest due to the broader applications of nanoparticles in our daily lives. The exposure of nanoparticles can lead to hypersecretion and accumulation of airway mucus which are closely associated with many respiratory diseases. Titanium dioxide (TiO2 ), one of the PM10 components, is a major NP that is widely utilized in many commercial products. Our previous study established the connection between induced airway mucus secretion and TiO2 NPs...
August 1, 2018: Science of the Total Environment
Songqi Liu, Chao Wang, Jun Hou, Peifang Wang, Lingzhan Miao, Xiulei Fan, Guoxiang You, Yi Xu
The widespread use of commercial silver nanoparticles (Ag NPs) inevitably results in their increased release into natural waters and subsequent deposition in sediments, requiring the environmental impact of such deposition to be closely investigated. Hence, the effects of Ag NPs, polyvinylpyrrolidone (PVP)-Ag NPs, and sliver sulfide nanoparticles (Ag2 S NPs) on denitrification-induced gas production (N2 O and 15 N-N2 ), and denitrifying microbes in freshwater sediments were investigated. Slurry experiments (8 h) combined with a 15 NO3 - addition technique were performed to determine the gaseous production...
June 15, 2018: Water Research
Adriano Magesky, Émilien Pelletier
Silver nanoparticles (AgNPs) incorporation in commercial products is increasing due to their remarkable physical and chemical properties and their low cost on the market. Silver has been known for a long time to be highly toxic to bacterial communities, aquatic organisms, and particularly to marine biota. Strong chloro-complexes dominate Ag speciation in seawater and facilitate its persistence in dissolved form. It has a great impact on marine organisms because low concentration of silver can lead to strong bioaccumulation, partly because the neutral silver chloro complex (AgCl0 ) is highly bioavailable...
2018: Advances in Experimental Medicine and Biology
Sourabh Dwivedi, Quaiser Saquib, Bilal Ahmad, Sabiha M Ansari, Ameer Azam, Javed Musarrat
The wider applications of nanoparticles (NPs) has evoked a world-wide concern due to their possible risk of toxicity in humans and other organisms. Aggregation and accumulation of NPs into cell leads to their interaction with biological macromolecules including proteins, nucleic acids and cellular organelles, which eventually induce toxicological effects. Application of toxicogenomics to investigate molecular pathway-based toxicological consequences has opened new vistas in nanotoxicology research. Indeed, genomic approaches appeared as a new paradigm in terms of providing information at molecular levels and have been proven to be as a powerful tool for identification and quantification of global shifts in gene expression...
2018: Advances in Experimental Medicine and Biology
Yubin Li, Dianwen Ju
In the past decades, nanoparticles have been widely used in industry and pharmaceutical fields for drug delivery, anti-pathogen, and diagnostic imaging purposes because of their unique physicochemical characteristics such as special ultrastructure, dispersity, and effective cellular uptake properties. But the nanotoxicity has been raised over the extensive applications of nanoparticles. Researchers have elucidated series of mechanisms in nanoparticles-induced toxicity, including apoptosis, necrosis, oxidative stress, and autophagy...
2018: Advances in Experimental Medicine and Biology
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