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https://www.readbyqxmd.com/read/28484751/bioapplications-of-renal-clearable-luminescent-metal-nanoparticles
#1
REVIEW
Lingshan Gong, Yaping Wang, Jinbin Liu
Renal-clearable inorganic nanoparticles (NPs) that hold great potential in the future clinic translations are considered as the next generation of nanomedicine. In the past decade, enormous efforts have been dedicated to the development of renal-clearable NPs with fascinating optical properties, selective disease-targeting capabilities and low nanotoxicities. A further understanding of the design of renal-clearable luminescent metal NPs and their metabolic behavior in the body is important to achieve their clinical transition and extend their bioapplications in disease theranostics...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28478677/nanotoxicity-in-systemic-circulation-and-wound-healing
#2
Mandeep Singh Bakshi
Nanotoxicity of nanomaterials is an important issue in view of their potential applications in systemic circulation and wound healing dressing. This account specifically deals with several characteristic features of different nanomaterials which induce hemolysis and how to make them hemocompatible. The shape, size, and surface functionalities of naked metallic as well as nonmetallic nanoparticles surfaces are responsible for the hemolysis. An appropriate coating of biocompatible molecules dramatically reduces hemolysis and promotes their ability as safe drug delivery vehicles...
May 23, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28454554/impaired-lysosomal-activity-mediated-autophagic-flux-disruption-by-graphite-carbon-nanofibers-induce-apoptosis-in-human-lung-epithelial-cells-through-oxidative-stress-and-energetic-impairment
#3
Sandeep Mittal, Pradeep Kumar Sharma, Ratnakar Tiwari, Raja Gopal Rayavarapu, Jai Shankar, Lalit Kumar Singh Chauhan, Alok Kumar Pandey
BACKGROUND: Graphite carbon nanofibers (GCNF) have emerged as a potential alternative of carbon nanotubes (CNT) for various biomedical applications due to their superior physico-chemical properties. Therefore in-depth understanding of the GCNF induced toxic effects and underlying mechanisms in biological systems is of great interest. Currently, autophagy activation by nanomaterials is recognized as an emerging toxicity mechanism. However, the association of GCNF induced toxicity with this form of cell death is largely unknown...
April 28, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28437696/different-toxicity-of-anatase-and-rutile-tio2-nanoparticles-on-macrophages-involvement-of-difference-in-affinity-to-proteins-and-phospholipids
#4
Qilin Yu, Honggang Wang, Qi Peng, Ye Li, Zhe Liu, Mingchun Li
TiO2 nanoparticles (NPs) are well-known nanomaterials (NMs), widely used in cosmetics, solar cells, photo-catalysts and additives. Anatase and rutile are the two main crystalline phases of TiO2 NPs and have distinct electrical and optical properties. However, their relative toxicity to organisms is a current topic of debate. In this study, we synthesize both anatase NPs (TiO2-A) and rutile NPs (TiO2-R) with similar particle sizes (20-40nm), surface areas (51-52m(2)/g) and Zeta potentials (-13.4 to -13.7mV), and investigate their toxicity to macrophages...
April 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28436678/nanotoxicity-modelling-and-removal-efficiencies-of-znonp-with-consortium
#5
Şeyda Fikirdeşici Ergen, Esra Üçüncü Tunca
In this paper the aim is to model the toxic effect of zinc oxide nanoparticles (ZnONP) and is to analyze the removal of ZnONP in aqueous medium by the consortium consisted of Daphnia magna and Lemna minor. Three separate test groups are formed: L. minor (L), D. magna (D) and L.minor+D.magna (L+D) and all these test groups are exposed to three different nanoparticle concentrations (0.3;3.0 and 30.0 mg L(-)(1)). Time-dependent, concentration-dependent and group-dependent removal efficiencies are statistically compared by non-parametric Mann-Whitney U test and statistically significant differences are observed...
April 24, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28422481/gold-nanoparticles-induced-endothelial-leakiness-depends-on-particle-size-and-endothelial-cell-origin
#6
Magdiel I Setyawati, Chor Yong Tay, Boon Huat Bay, David T Leong
The endothelium presents a formidable barrier for cancer nanomedicine, as the intravenously introduced nanomedicine needs to leave the blood vessel at the tumor site. Endothelial permeability and retention effect (EPR) is not dependable since it is derived from tumors. Certain nanoparticles with specific characteristics are able to induce micrometer sized gaps between endothelial cells. This effect is called "nanoparticle induced endothelial leakiness" (NanoEL). NanoEL therefore allows the nanotechnology to control access to the tumor even in the absence of any EPR effect...
April 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28415402/fattigation-platform-theranostic-nanoparticles-for-cancer-therapy
#7
Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Tae-Jong Yoon, Beom-Jin Lee
A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatible shell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a useful theranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatin were conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities: 1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobic chemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnostic agent with low nanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of the incorporated drug in cells and in an animal model...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28373829/hazardous-effects-of-titanium-dioxide-nanoparticles-in-ecosystem
#8
REVIEW
Syed Niaz Ali Shah, Zahir Shah, Muzammal Hussain, Muzaffar Khan
Although nanoparticles (NPs) have made incredible progress in the field of nanotechnology and biomedical research and their applications are demanded throughout industrial world particularly over the past decades, little is known about the fate of nanoparticles in ecosystem. Concerning the biosafety of nanotechnology, nanotoxicity is going to be the second most priority of nanotechnology that needs to be properly addressed. This review covers the chemical as well as the biological concerns about nanoparticles particularly titanium dioxide (TiO2) NPs and emphasizes the toxicological profile of TiO2 at the molecular level in both in vitro and in vivo systems...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28373085/choose-your-cell-model-wisely-the-in-vitro-nanoneurotoxicity-of-differentially-coated-iron-oxide-nanoparticles-for-neural-cell-labeling
#9
Freya Joris, Daniel Valdepérez, Beatriz Pelaz, Tianqiang Wang, Shareen H Doak, Bella B Manshian, Stefaan J Soenen, Wolfgang J Parak, Stefaan C De Smedt, Koen Raemdonck
Currently, there is a large interest in the labeling of neural stem cells (NSCs) with iron oxide nanoparticles (IONPs) to allow MRI-guided detection after transplantation in regenerative medicine. For such biomedical applications, excluding nanotoxicity is key. Nanosafety is primarily evaluated in vitro where an immortalized or cancer cell line of murine origin is often applied, which is not necessarily an ideal cell model. Previous work revealed clear neurotoxic effects of PMA-coated IONPs in distinct cell types that could potentially be applied for nanosafety studies regarding neural cell labeling...
March 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28363143/nanotoxicity-of-graphene-oxide-assessing-the-influence-of-oxidation-debris-in-the-presence-of-humic-acid
#10
Zaira Clemente, Vera Lúcia S S Castro, Lidiane S Franqui, Cristiane A Silva, Diego Stéfani T Martinez
This study sought to evaluate the toxicological effects of graphene oxide (GO) through tests with Danio rerio (zebrafish) embryos, considering the influence of the base washing treatment and the interaction with natural organic matter (i.e., humic acid, HA). A commercial sample of GO was refluxed with NaOH to remove oxidation debris (OD) byproducts, which resulted in a base washed GO sample (bw-GO). This process decreased the total oxygenated groups in bw-GO and its stability in water compared to GO. When tested in the presence of HA, both GO and bw-GO stabilities were enhanced in water...
March 28, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28333444/host-symbiont-interaction-model-explains-non-monotonic-response-of-soybean-growth-and-seed-production-to-nano-ceo2-exposure
#11
Tin Klanjšček, Erik B Muller, Patricia A Holden, Roger M Nisbet
Recent nanotoxicity studies have demonstrated non-monotonic dose-response mechanisms for planted soybean that have a symbiotic relationship with bacteroids in their root nodules: reduction of growth and seed production was greater for low, as compared to high, exposures. To investigate mechanistic underpinnings of the observed patterns, we formulated an energy budget model coupled to a toxicokinetic module describing bioaccumulation, and two toxicodynamic modules describing toxic effects on host plant and symbionts...
April 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28318601/strategies-and-knowledge-gaps-for-improving-nanomaterial-biocompatibility
#12
REVIEW
Xiangang Hu, Anqi Sun, Weilu Kang, Qixing Zhou
With rapid development of nanotechnology and nanomaterials, nanosafety has attracted wide attention in all fields related to nanotechnology. As well known, a grand challenge in nanomaterial applications is their biocompatibility. It is urgent to explore effective strategies to control the unintentional effects. Although many novel methods for the synthesis of biocompatible and biodegradable nanomaterials are reported, the control strategy of nanotoxicity remains in its infancy. It is urgent to review the archived strategies for improving nanomaterial biocompatibility to clarify what we have done and where we should be...
March 15, 2017: Environment International
https://www.readbyqxmd.com/read/28303908/disruption-of-autolysis-in-bacillus-subtilis-using-tio2-nanoparticles
#13
Eric McGivney, Linchen Han, Astrid Avellan, Jeanne VanBriesen, Kelvin B Gregory
In contrast to many nanotoxicity studies where nanoparticles (NPs) are observed to be toxic or reduce viable cells in a population of bacteria, we observed that increasing concentration of TiO2 NPs increased the cell survival of Bacillus subtilis in autolysis-inducing buffer by 0.5 to 5 orders of magnitude over an 8 hour exposure. Molecular investigations revealed that TiO2 NPs prevent or delay cell autolysis, an important survival and growth-regulating process in bacterial populations. Overall, the results suggest two potential mechanisms for the disruption of autolysis by TiO2 NPs in a concentration dependent manner: (i) directly, through TiO2 NP deposition on the cell wall, delaying the collapse of the protonmotive-force and preventing the onset of autolysis; and (ii) indirectly, through adsorption of autolysins on TiO2 NP, limiting the activity of released autolysins and preventing further lytic activity...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301688/multiplex-single-cell-quantification-of-rare-rna-transcripts-from-protoplasts-in-a-model-plant-system
#14
Ulhas S Kadam, Burkhard Schulz, Joseph M K Irudayaraj
Here we demonstrate multiplex and simultaneous detection of four different rare RNA species from plant, Arabidopsis thaliana, using surface enhanced Raman spectroscopy and gold nanoprobes at single cell resolution. We show the applicability of nanoparticle-based Raman spectroscopic sensor to study intracellular RNA copies. First, we demonstrate that gold-nanoparticles decorate with Raman probes and carrying specific nucleic acid probe sequences can be uptaken by the protoplasts. We confirm the internalization of gold nanoprobes by TEM, ICP-MS, and fluorescence imaging...
March 16, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28261221/allergic-responses-induced-by-the-immunomodulatory-effects-of-nanomaterials-upon-skin-exposure
#15
REVIEW
Yasuo Yoshioka, Etsushi Kuroda, Toshiro Hirai, Yasuo Tsutsumi, Ken J Ishii
Over the past decade, a vast array of nanomaterials has been created through the development of nanotechnology. With the increasing application of these nanomaterials in various fields, such as foods, cosmetics, and medicines, there has been concern about their safety, that is, nanotoxicity. Therefore, there is an urgent need to collect information about the biological effects of nanomaterials so that we can exploit their potential benefits and design safer nanomaterials, while avoiding nanotoxicity as a result of inhalation or skin exposure...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28248594/dissecting-common-and-divergent-molecular-pathways-elicited-by-cdse-zns-quantum-dots-in-freshwater-and-marine-sentinel-invertebrates
#16
Alfredo Ambrosone, Modi Roopin, Beatriz Pelaz, Abuelmagd M Abdelmonem, Lisa-Maria Ackermann, Lucia Mattera, Mariateresa Allocca, Angela Tino, Markus Klapper, Wolfgang J Parak, Oren Levy, Claudia Tortiglione
Water ecosystems represent main targets of unintentional contamination of nanomaterials, due to industrial waste or other anthropogenic activities. Nanoparticle insult to living organisms may occur in a sequential way, first by chemical interactions of the material with the target membrane, then by progressive internalisation and interaction with cellular structures and organelles. These events trigger a signal transduction, through which cells modulate molecular pathway in order to respond and survive to the external elicitation...
March 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28168673/case-study-iii-the-construction-of-a-nanotoxicity-database-the-mod-enp-tox-experience
#17
Hanne Vriens, Dominik Mertens, Renaud Regret, Pinpin Lin, Jean-Pierre Locquet, Peter Hoet
The amount of experimental studies on the toxicity of nanomaterials is growing fast. Interpretation and comparison of these studies is a complex issue due to the high amount of variables possibly determining the toxicity of nanomaterials.Qualitative databases providing a structured combination, integration and quality evaluation of the existing data could reveal insights that cannot be seen from different studies alone. A few database initiatives are under development but in practice very little data is publicly available and collaboration between physicists, toxicologists, computer scientists and modellers is needed to further develop databases, standards and analysis tools...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28168672/compilation-of-data-and-modelling-of-nanoparticle-interactions-and-toxicity-in-the-nanopuzzles-project
#18
Andrea-Nicole Richarz, Aggelos Avramopoulos, Emilio Benfenati, Agnieszka Gajewicz, Nazanin Golbamaki Bakhtyari, Georgios Leonis, Richard L Marchese Robinson, Manthos G Papadopoulos, Mark Td Cronin, Tomasz Puzyn
The particular properties of nanomaterials have led to their rapidly increasing use in diverse fields of application. However, safety assessment is not keeping pace and there are still gaps in the understanding of their hazards. Computational models predicting nanotoxicity, such as (quantitative) structure-activity relationships ((Q)SARs), can contribute to safety evaluation, in line with general efforts to apply alternative methods in chemical risk assessment. Their development is highly dependent on the availability of reliable and high quality experimental data, both regarding the compounds' properties as well as the measured toxic effects...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28107957/methodology-for-monitoring-gold-nanoparticles-and-dissolved-gold-species-in-culture-medium-and-cells-used-for-nanotoxicity-tests-by-liquid-chromatography-hyphenated-to-inductively-coupled-plasma-mass-spectrometry
#19
Sara López-Sanz, Nuria Rodríguez Fariñas, Rosario Serrano Vargas, Rosa Del Carmen Rodríguez Martín-Doimeadios, Ángel Ríos
An analytical methodology based on coupling reversed-phase liquid chromatography (HPLC) to an inductively coupled plasma mass spectrometry (ICP-MS) has been developed for the characterization and identification of gold nanoparticles (AuNPs) and gold dissolved species (Au(3+)) in culture medium (Dulbecco's Modified Eagle Medium, DMEM) and HeLa cells (a human cervical adenocarcinoma cell line) used in nanotoxicity tests. The influence of the culture medium was also studied and the method applied for nanotoxicity tests...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107731/natural-amelioration-of-zinc-oxide-nanoparticle-toxicity-in-fenugreek%C3%A2-trigonella-foenum-gracum-by-arbuscular-mycorrhizal-glomus-intraradices-secretion-of-glomalin
#20
Narges Ghasemi Siani, Seyfollah Fallah, Lok Raj Pokhrel, Ali Rostamnejadi
Owing to rising production and use of engineered nanoparticles (ENPs) in the myriad of consumer applications, ENPs are being released into the environment where their potential fate and effects have remained unclear. With naturally occurring arbuscular mycorrhizal fungus (AMF; Glomus intraradices) in soils, their influence (positive or negative) on ENPs toxicity in plants is not well documented. Herein, we investigated potential influence of AMF on the growth and development in fenugreek (Trigonella foenum-graecum) under varied Zinc oxide nanoparticles (ZnONPs) treatments (0, 125, 250, 375 and 500 μg g(-1))...
March 2017: Plant Physiology and Biochemistry: PPB
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