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Nanotoxicity

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https://www.readbyqxmd.com/read/28733245/engineered-nanoparticles-for-the-detection-treatment-and-prevention-of-atherosclerosis-how-close-are-we
#1
REVIEW
Luong T H Nguyen, Aristo Muktabar, Jinkai Tang, Vinayak P Dravid, C Shad Thaxton, Subbu Venkatraman, Kee Woei Ng
Atherosclerosis is one of the leading causes of morbidity and mortality worldwide. Nanotechnology has provided the possibility of designing nanoparticles that can translocate through tissues and home in to atherosclerotic plaques to achieve desired diagnostic, therapeutic, theranostic or 'theralivery' outcomes. Although nanomedicine approaches have demonstrated exciting possibilities, clinical reality is still distant and challenges are aplenty, such as specificity of targeting and nanotoxicity. Nevertheless, developments in formulations, delivery strategies and experimental models over the coming years will generate new knowledge to define the true potential of this field...
July 18, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28722443/quantum-dot-nanotoxicity-investigations-using-human-lung-cells-and-toxor-electrochemical-enzyme-assay-methodology
#2
Tony O'Hara, Brian Seddon, Andrew O'Connor, Siobhán McClean, Baljit Singh, Emmanuel Iwuoha, Xolile Fuku, Eithne Dempsey
Recent studies have suggested that certain nanomaterials can interfere with optically based cytotoxicity assays resulting in underestimations of nanomaterial toxicity. As a result there has been growing interest in the use of whole cell electrochemical biosensors for nanotoxicity applications. Herein we report application of an electrochemical cytotoxicity assay developed in house (TOXOR) in the evaluation of toxic effects of mercaptosuccinic acid capped cadmium telluride quantum dots (MSA capped CdTe QDs), toward mammalian cells...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721038/toxicity-based-toxicokinetic-toxicodynamic-assessment-of-bioaccumulation-and-nanotoxicity-of-zerovalent-iron-nanoparticles-in-caenorhabditis-elegans
#3
Ying-Fei Yang, Yi-Jun Lin, Chung-Min Liao
Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe(0)) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe(0)NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28704975/current-knowledge-on-the-use-of-computational-toxicology-in-hazard-assessment-of-metallic-engineered-nanomaterials
#4
REVIEW
Guangchao Chen, Willie Peijnenburg, Yinlong Xiao, Martina G Vijver
As listed by the European Chemicals Agency, the three elements in evaluating the hazards of engineered nanomaterials (ENMs) include the integration and evaluation of toxicity data, categorization and labeling of ENMs, and derivation of hazard threshold levels for human health and the environment. Assessing the hazards of ENMs solely based on laboratory tests is time-consuming, resource intensive, and constrained by ethical considerations. The adoption of computational toxicology into this task has recently become a priority...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28689990/graphene-oxide-nanosheets-in-complex-with-cell-penetrating-peptides-for-oligonucleotides-delivery
#5
Moataz Dowaidar, Hani Nasser Abdelhamid, Mattias Hällbrink, Xiaodong Zou, Ülo Langel
A new strategy for gene transfection using the nanocarrier of cell penetrating peptides (CPPs; PepFect14 (PF14) or PepFect14 (PF14) (PF221)) in complex with graphene oxide (GO) is reported. GO complexed with CPPs and plasmid (pGL3), splice correction oligonucleotides (SCO) or small interfering RNA (siRNA) are performed. Data show adsorption of CPPs and oligonucleotides on the top of the graphenic lamellar without any observed change of the particle size of GO. GO mitigates the cytotoxicity of CPPs and improves the material biocompatibility...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28689059/epigenetic-modulations-in-nanoparticle-mediated-toxicity
#6
Belinda Shu Ee Wong, Qidong Hu, Gyeong Hun Baeg
The increasing application of nanoparticles in healthcare and consumer products has made them ever present in our lives. However, constant exposure to these nanoparticles has raised concerns regarding their adverse side effects on human health, signifying the great importance of nanotoxicity studies. Indeed, extensive in vitro and in vivo studies in this field have provided valuable insights into the potential cytotoxicity and genotoxicity induced by nanoparticles. Interestingly, there is a growing body of evidence that nanoparticles can also induce epigenetic changes...
July 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28687867/effect-of-multi-walled-carbon-nanotubes-on-metabolism-and-morphology-of-filamentous-green-microalgae
#7
Michele Munk, Humberto M Brandão, Claude Yéprémian, Alain Couté, Luiz O Ladeira, Nádia R B Raposo, Roberta Brayner
Multi-walled carbon nanotubes (MWCNTs) have potential applications in the industrial, agricultural, pharmaceutical, medical, and environmental remediation fields. However, many uncertainties exist regarding the environmental implications of engineered nanomaterials. This study examined the effect of the MWCNTs on metabolic status and morphology of filamentous green microalgae Klebsormidium flaccidum. Appropriate concentrations of MWCNT (1, 50, and 100 μg mL(-1)) were added to a microalgal culture in the exponential growth phase and incubated for 24, 48, 72, and 96 h...
July 7, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28673184/toxicogenomics-of-iron-oxide-nanoparticles-in-the-nematode-c-elegans
#8
Laura Gonzalez-Moragas, Si-Ming Yu, Núria Benseny-Cases, Stephen Stürzenbaum, Anna Roig, Anna Laromaine
We present a mechanistic study of the effect of iron oxide nanoparticles (SPIONs) in Caenorhabditis elegans combining a genome-wide analysis with the investigation of specific molecular markers frequently linked to nanotoxicity. The effects of two different coatings were explored: citrate, an anionic stabilizer, and bovine serum albumin, as a pre-formed protein corona. The transcriptomic study identified differentially expressed genes following an exposure to SPIONs. The expression of genes involved in oxidative stress, metal detoxification response, endocytosis, intestinal integrity and iron homeostasis was quantitatively evaluated...
July 4, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28620743/understanding-the-interactions-of-human-follicle-stimulating-hormone-with-single-walled-carbon-nanotubes-by-molecular-dynamics-simulation-and-free-energy-analysis
#9
Yasaman Mahmoodi, Faramarz Mehrnejad, Khosrow Khalifeh
Interactions of carbon nanotubes (CNTs) and blood proteins are of interest for nanotoxicology and nanomedicine. It is believed that the interactions of blood proteins and glycoproteins with CNTs may have important biological effects. In spite of many experimental studies of single-walled carbon nanotubes (SWCNT) and glycoproteins with different methods, little is known about the atomistic details of their association process or of structural alterations occurring in adsorbed glycoproteins. In this study, we have applied molecular dynamics simulation to investigate the interaction of follicle stimulating hormone (hFSH) with SWCNT...
June 15, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28614664/molecular-mechanisms-of-developmental-toxicity-induced-by-graphene-oxide-at-predicted-environmental-concentrations
#10
Xingli Zhang, Qixing Zhou, Wei Zou, Xiangang Hu
Developmental toxicity is a critical issue in nanotoxicity. However, very little is known about the effects of graphene oxide (GO, a widely used carbon material) at predicted environmental concentrations on biological development or the specific molecular mechanisms. The present study established that the development of zebrafish embryos exposed to trace concentrations (1-100 μg/L) of GO was impaired because of DNA modification, protein carbonylation and excessive generation of reactive oxygen species (ROS), especially the superoxide radical...
June 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28605996/in-vitro-exposure-of-bull-sperm-cells-to-dmsa-coated-maghemite-nanoparticles-does-not-affect-cell-functionality-or-structure
#11
Denise Ferreira Caldeira, Fernanda Paulini, Renata Carvalho Silva, Ricardo Bentes de Azevedo, Carolina Madeira Lucci
Magnetic nanoparticles can be used in different areas of biology. It is therefore important to know the effects of such nanomaterials on germline cells as they may traverse the blood-testis barrier. This work aimed to evaluate the response of bull sperm after exposure to a magnetic fluid containing DMSA-coated maghemite nanoparticles (MNP-DMSA) in order to determine nanotoxicity. Bull sperm was incubated with MNP-DMSA at final concentrations of 0.06, 0.03 or 0.015 mg Fe/mL. Sperm kinetics, plasma membrane integrity and acrosome reaction were evaluated over a four-hour incubation period...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28604902/what-if-the-number-of-nanotoxicity-data-is-too-small-for-developing-predictive-nano-qsar-models-an-alternative-read-across-based-approach-for-filling-data-gaps
#12
Agnieszka Gajewicz
Over the past decade, computational nanotoxicology, in particular Quantitative Structure-Activity Relationship models (Nano-QSAR) that help in assessing the biological effects of nanomaterials, have received much attention. In effect, a solid basis for uncovering the relationships between the structure and property/activity of nanoparticles has been created. Nonetheless, six years after the first pioneering computational studies focusing on the investigation of nanotoxicity were commenced, these computational methods still suffer from many limitations...
June 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28565931/histopathology-and-analyses-of-inflammation-intensity-in-the-gills-of-mussels-exposed-to-silver-nanoparticles-role-of-nanoparticle-size-exposure-time-and-uptake-pathways
#13
Younes Bouallegui, Ridha Ben Younes, Houda Bellamine, Ridha Oueslati
Environmentally induced perturbation of health parameters lead to morphological changes associated to the inflammatory response. Hematoxyline and eosin (H&E)-stained gill filaments sections were examined for such changes and inflammation intensity was scored according to a quantitative model in order to evaluate the health status of in vivo exposed (for 3, 6, and 12 h) mussels to silver nanoparticles (Ag-NPs <50 nm and Ag-NPs <100 nm) prior and after the inhibition of two potential uptake pathways (clathrin- and caveolae-mediated endocytosis) with the aid of pharmaceutical inhibitors (amantadine and nystatin)...
June 21, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28484751/bioapplications-of-renal-clearable-luminescent-metal-nanoparticles
#14
REVIEW
Lingshan Gong, Yaping Wang, Jinbin Liu
Renal-clearable inorganic nanoparticles (NPs) that hold great potential in the future clinic translations are considered as the next generation of nanomedicine. In the past decade, enormous efforts have been dedicated to the development of renal-clearable NPs with fascinating optical properties, selective disease-targeting capabilities and low nanotoxicities. A further understanding of the design of renal-clearable luminescent metal NPs and their metabolic behavior in the body is important to achieve their clinical transition and extend their bioapplications in disease theranostics...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28478677/nanotoxicity-in-systemic-circulation-and-wound-healing
#15
Mandeep Singh Bakshi
Nanotoxicity of nanomaterials is an important issue in view of their potential applications in systemic circulation and wound healing dressing. This account specifically deals with several characteristic features of different nanomaterials which induce hemolysis and how to make them hemocompatible. The shape, size, and surface functionalities of naked metallic as well as nonmetallic nanoparticles surfaces are responsible for the hemolysis. An appropriate coating of biocompatible molecules dramatically reduces hemolysis and promotes their ability as safe drug delivery vehicles...
May 23, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28454554/impaired-lysosomal-activity-mediated-autophagic-flux-disruption-by-graphite-carbon-nanofibers-induce-apoptosis-in-human-lung-epithelial-cells-through-oxidative-stress-and-energetic-impairment
#16
Sandeep Mittal, Pradeep Kumar Sharma, Ratnakar Tiwari, Raja Gopal Rayavarapu, Jai Shankar, Lalit Kumar Singh Chauhan, Alok Kumar Pandey
BACKGROUND: Graphite carbon nanofibers (GCNF) have emerged as a potential alternative of carbon nanotubes (CNT) for various biomedical applications due to their superior physico-chemical properties. Therefore in-depth understanding of the GCNF induced toxic effects and underlying mechanisms in biological systems is of great interest. Currently, autophagy activation by nanomaterials is recognized as an emerging toxicity mechanism. However, the association of GCNF induced toxicity with this form of cell death is largely unknown...
April 28, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28437696/different-toxicity-of-anatase-and-rutile-tio2-nanoparticles-on-macrophages-involvement-of-difference-in-affinity-to-proteins-and-phospholipids
#17
Qilin Yu, Honggang Wang, Qi Peng, Ye Li, Zhe Liu, Mingchun Li
TiO2 nanoparticles (NPs) are well-known nanomaterials (NMs), widely used in cosmetics, solar cells, photo-catalysts and additives. Anatase and rutile are the two main crystalline phases of TiO2 NPs and have distinct electrical and optical properties. However, their relative toxicity to organisms is a current topic of debate. In this study, we synthesize both anatase NPs (TiO2-A) and rutile NPs (TiO2-R) with similar particle sizes (20-40nm), surface areas (51-52m(2)/g) and Zeta potentials (-13.4 to -13.7mV), and investigate their toxicity to macrophages...
April 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28436678/nanotoxicity-modelling-and-removal-efficiencies-of-znonp-with-consortium
#18
Şeyda Fikirdeşici Ergen, Esra Üçüncü Tunca
In this paper the aim is to model the toxic effect of zinc oxide nanoparticles (ZnONP) and is to analyze the removal of ZnONP in aqueous medium by the consortium consisted of Daphnia magna and Lemna minor. Three separate test groups are formed: L. minor (L), D. magna (D) and L.minor+D.magna (L+D) and all these test groups are exposed to three different nanoparticle concentrations (0.3;3.0 and 30.0 mg L(-)(1)). Time-dependent, concentration-dependent and group-dependent removal efficiencies are statistically compared by non-parametric Mann-Whitney U test and statistically significant differences are observed...
April 24, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28422481/gold-nanoparticles-induced-endothelial-leakiness-depends-on-particle-size-and-endothelial-cell-origin
#19
Magdiel I Setyawati, Chor Yong Tay, Boon Huat Bay, David T Leong
The endothelium presents a formidable barrier for cancer nanomedicine, as the intravenously introduced nanomedicine needs to leave the blood vessel at the tumor site. Endothelial permeability and retention effect (EPR) is not dependable since it is derived from tumors. Certain nanoparticles with specific characteristics are able to induce micrometer sized gaps between endothelial cells. This effect is called "nanoparticle induced endothelial leakiness" (NanoEL). NanoEL therefore allows the nanotechnology to control access to the tumor even in the absence of any EPR effect...
April 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28415402/fattigation-platform-theranostic-nanoparticles-for-cancer-therapy
#20
Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Tae-Jong Yoon, Beom-Jin Lee
A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatible shell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a useful theranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatin were conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities: 1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobic chemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnostic agent with low nanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of the incorporated drug in cells and in an animal model...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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