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Nanotoxicity

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https://www.readbyqxmd.com/read/28067384/nanocaged-platforms-modification-drug-delivery-and-nanotoxicity-opening-synthetic-cages-to-release-the-tiger
#1
REVIEW
Parham Sahandi Zangabad, Mahdi Karimi, Fatemeh Mehdizadeh, Hedieh Malekzad, Alireza Ghasemi, Sajad Bahrami, Hossein Zare, Mohsen Moghoofei, Amin Hekmatmanesh, Michael R Hamblin
Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe)...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067319/c-elegans-on-a-chip-for-in-situ-and-in-vivo-ag-nanoparticles-uptake-and-toxicity-assay
#2
Jin Ho Kim, Seung Hwan Lee, Yun Jeong Cha, Sung Jin Hong, Sang Kug Chung, Tai Hyun Park, Shin Sik Choi
Nanomaterials are extensively used in consumer products and medical applications, but little is known about their environmental and biological toxicities. Moreover, the toxicity analysis requires sophisticated instruments and labor-intensive experiments. Here we report a microfluidic chip incorporated with the nematode Caenorhabditis elegans that rapidly displays the changes in body growth and gene expression specifically responsive to the silver nanoparticles (AgNPs). C. elegans were cultured in microfluidic chambers in the presence or absence of AgNPs and were consequently transferred to wedge-shaped channels, which immobilized the animals, allowing the evaluation of parameters such as length, moving distance, and fluorescence from the reporter gene...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28038758/nanosponge-cyclodextrin-polyurethanes-and-their-modification-with-nanomaterials-for-the-removal-of-pollutants-from-waste-water-a-review
#3
REVIEW
Anny Leudjo Taka, Kriveshini Pillay, Xavier Yangkou Mbianda
Water is a worldwide vital resource for sustaining life and due to the pollution of water by different classes of pollutants (inorganic, organic and pathogens), many ongoing studies in water purification remain a critical issue to governments, scientists and industries. The challenge is to develop a water purification technology which will be effective at removing these contaminants simultaneously and reducing their concentrations to ultra low levels from waste water. This review article serves to give an overview on cyclodextrin nanosponge adsorbents which have already been used for water treatment...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28031960/the-melding-of-nanomedicine-in-thrombosis-imaging-and-treatment-a-review
#4
REVIEW
Varvara Karagkiozaki, Foteini Pappa, Despoina Arvaniti, Anestis Moumkas, Dimitrios Konstantinou, Stergios Logothetidis
Thromboembolic diseases constitute a plague in our century, wherein an imbalance of hemostasis leads to thrombus formation and vessels constriction reducing blood flow. Hence, the recent rise of nanomedicine gives birth to advanced diagnostic modalities and therapeutic agents for the early diagnosis and treatment of such diseases. Multimodal nanoagents for the detection of intravascular thrombi and nanovehicles for thrombus-targeted fibrinolytic therapy are few paradigms of nanomedicine approaches to overcome current diagnostic treatment roadblocks and persistent clinical needs...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28024936/nanotoxicity-of-cobalt-induced-by-oxidant-generation-and-glutathione-depletion-in-mcf-7-cells
#5
Mohd Javed Akhtar, Maqusood Ahamed, Hisham A Alhadlaq, Aws Alshamsan
There are very few studies regarding the biological activity of cobalt-based nanoparticles (NPs) and, therefore, the possible mechanism behind the biological response of cobalt NPs has not been fully explored. The present study was designed to explore the potential mechanisms of the cytotoxicity of cobalt NPs in human breast cancer (MCF-7) cells. The shape and size of cobalt NPs were characterized by scanning and transmission electron microscopy (SEM and TEM). The crystallinity of NPs was determined by X-ray diffraction (XRD)...
December 23, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27987725/in-vitro-and-in-vivo-assessment-of-nanotoxicity-of-cds-quantum-dot-aminopolysaccharide-bionanoconjugates
#6
S M de Carvalho, A A P Mansur, H S Mansur, M I M C Guedes, Z I P Lobato, M F Leite
The nanotoxicity of Cd-containing quantum dots (QDs) for biomedical applications is very controversial and not completely understood. In this study, we evaluated the cytotoxicity of surface-biofunctionalized CdS QDs with chitosan directly synthesized via aqueous route at room temperature. These core-shell CdS-chitosan nanoconjugates showed different degrees of cytotoxic responses using MTT cell proliferation assay toward three human cell cultures, human osteosarcoma cell line (SAOS), non-Hodgkin's B cell lymphoma (Toledo), and human embryonic kidney cell line (HEK293T), under three exposure times (1, 3, and 5days) and three colloidal concentrations (10nM, 50nM, and 100nM)...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27982583/standard-cellular-testing-conditions-generate-an-exaggerated-nanoparticle-cytotoxicity-profile
#7
Bella B Manshian, Uwe Himmelreich, Stefaan J Soenen
Cellular internalization of nanoparticles (NPs) is key to many biomedical applications and serves as a model to investigate the potential toxicity of NPs on entire organisms. Large discrepancies between in vitro and in vivo nanotoxicity data however exist, suggesting that cellular systems may not be optimal for predictive in vivo toxicology. Here, we use validated multiparametric high-content imaging protocols to evaluate the impact of common cell culture conditions on NP cytotoxicity studies. The data show that high NP to cell ratios, typical for cellular studies, stress the cells by high endocytosis levels that overstimulate mitochondria, resulting in oxidative stress-mediated mitochondrial damage, which induces autophagy...
December 16, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27951703/modeling-the-hydrophobicity-of-nanoparticles-and-their-interaction-with-lipids-and-proteins
#8
Ali Ramazani, Taraknath Mandal, Ronald G Larson
We present a method of modeling nanoparticle (NP) hydrophobicity using coarse-grained molecular dynamics (CG MD) simulations, and apply this to the interaction of lipids with nanoparticles. To model at a coarse-grained level the wettability or hydrophobicity of a given material, we choose the MARTINI coarse-grained force field, and determine through simulation the contact angles of MARTINI water droplets residing on flat regular surfaces composed of various MARTINI bead types (C1, C2, etc.). Each surface is composed of a single bead type in each of three crystallographic symmetries (FCC, BCC, and HCP)...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27942214/nanotoxicity-emerging-concerns-regarding-nanomaterial-safety-and-occupational-hard-metal-wc-co-nanoparticle-exposure
#9
REVIEW
Andrea L Armstead, Bingyun Li
As the number of commercial and consumer products containing engineered nanomaterials (ENMs) continually rises, the increased use and production of these ENMs presents an important toxicological concern. Although ENMs offer a number of advantages over traditional materials, their extremely small size and associated characteristics may also greatly enhance their toxic potentials. ENM exposure can occur in various consumer and industrial settings through inhalation, ingestion, or dermal routes. Although the importance of accurate ENM characterization, effective dosage metrics, and selection of appropriate cell or animal-based models are universally agreed upon as important factors in ENM research, at present, there is no "standardized" approach used to assess ENM toxicity in the research community...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27920526/in-vitro-inflammatory-effects-of-hard-metal-wc-co-nanoparticle-exposure
#10
Andrea L Armstead, Bingyun Li
Identifying the toxicity of nanoparticles (NPs) is an important area of research as the number of nanomaterial-based consumer and industrial products continually rises. In addition, the potential inflammatory effects resulting from pulmonary NP exposure are emerging as an important aspect of nanotoxicity. In this study, the toxicity and inflammatory state resulting from tungsten carbide-cobalt (WC-Co) NP exposure in macrophages and a coculture (CC) of lung epithelial cells (BEAS-2B) and macrophages (THP-1) at a 3:1 ratio were examined...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27872490/use-of-zebrafish-larvae-as-a-multi-endpoint-platform-to-characterize-the-toxicity-profile-of-silica-nanoparticles
#11
Duc-Hung Pham, Bert De Roo, Xuan-Bac Nguyen, Mattias Vervaele, Angela Kecskés, Annelii Ny, Daniëlle Copmans, Hanne Vriens, Jean-Pierre Locquet, Peter Hoet, Peter A M de Witte
Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity profile is poorly characterized. In this study, we investigated the toxicity of silica nanoparticles with diameters 20, 50 and 80 nm using an in vivo zebrafish platform that analyzes multiple endpoints related to developmental, cardio-, hepato-, and neurotoxicity...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768974/artificially-controlled-degradable-inorganic-nanomaterial-for-cancer-theranostics
#12
Yuxin Liu, Ge Zhang, Quanwei Guo, Liyi Ma, Qi Jia, Lidong Liu, Jing Zhou
Multifunctional nanomaterials for cancer diagnosis and therapy have recently prompted widespread concern. To avoid nanotoxicity, the development of novel degradable functional materials must be our main focus. In this study, we firstly developed ethylenediaminetetraacetic acid calcium disodium salt (EDTA)- and bovine serum albumin (BSA)-capped Mn3O4 nanoparticles (MONPs-BSA-EDTA) as a novel inorganic nanomaterials for multifunctional imaging-guided photothermal therapy, which can be degraded in a progress-controlled way by artificially introduced ascorbic acid...
October 17, 2016: Biomaterials
https://www.readbyqxmd.com/read/27758683/nanocrystal-based-drug-delivery-system-conventional-and-current-scenario
#13
Shreya Thakkar, Viral Shah, Manju Misra, Kiran Kalia
BACKGROUND: Most of the chemical substances which emerge out as potential drug candidates (Active Pharmaceutical Ingredients) are either weak acids or weak bases. Poor aqueous solubility of these drug substances is a common concern. Several R&D centers are focused on developing suitable, economic, simpler and more feasible solubility enhancement techniques for increasing the solubility and thereby bioavailability of such drug substances. Nanocrystals is one of the preferred approaches for solubility enhancement in last few decades...
October 14, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27718008/influence-of-nanotoxicity-on-human-health-and-environment-the-alternative-strategies
#14
Buddolla Viswanath, Sanghyo Kim
Currently, nanotechnology revolutionizing both scientific and industrial community due to their applications in the fields of medicine, environmental protection, energy, and space exploration. Despite of the evident benefits of nanoparticles, there are still open questions about the influence of these nanoparticles on human health and environment. This is one of the critical issues that have to be addressed in the near future, before massive production of nanomaterials. Manufactured nanoparticles, which are finding ever-increasing applications in industry and consumer products fall into the category of emerging contaminants with ecological and toxicological effects on populations, communities and ecosystems...
2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27714104/a-3d-co-culture-microtissue-model-of-the-human-placenta-for-nanotoxicity-assessment
#15
Carina Muoth, Adrian Wichser, Marco Monopoli, Manuel Correia, Nicky Ehrlich, Katrin Loeschner, Audrey Gallud, Melanie Kucki, Liliane Diener, Pius Manser, Wolfram Jochum, Peter Wick, Tina Buerki-Thurnherr
There is increasing evidence that certain nanoparticles (NPs) can overcome the placental barrier, raising concerns on potential adverse effects on the growing fetus. But even in the absence of placental transfer, NPs may pose a risk to proper fetal development if they interfere with the viability and functionality of the placental tissue. The effects of NPs on the human placenta are not well studied or understood, and predictive in vitro placenta models to achieve mechanistic insights on NP-placenta interactions are essentially lacking...
October 6, 2016: Nanoscale
https://www.readbyqxmd.com/read/27695325/surface-biofunctionalized-cds-and-zns-quantum-dot-nanoconjugates-for-nanomedicine-and-oncology-to-be-or-not-to-be-nanotoxic
#16
Alexandra Ap Mansur, Herman S Mansur, Sandhra M de Carvalho, Zélia Ip Lobato, Maria Imc Guedes, Maria F Leite
Herein, for the first time, we demonstrated that novel biofunctionalized semiconductor nanomaterials made of Cd-containing fluorescent quantum dot nanoconjugates with the surface capped by an aminopolysaccharide are not biologically safe for clinical applications. Conversely, the ZnS-based nanoconjugates proved to be noncytotoxic, considering all the parameters investigated. The results of in vitro cytotoxicity were remarkably dependent on the chemical composition of quantum dot (CdS or ZnS), the nature of the cell (human cancerous and embryonic types), and the concentration and time period of exposure to these nanomaterials, caused by the effects of Cd(2+) on the complex nanotoxicity pathways involved in cellular uptake...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27669995/reproductive-toxicity-and-gender-differences-induced-by-cadmium-telluride-quantum-dots-in-an-invertebrate-model-organism
#17
Si-Qi Yan, Rui Xing, Yan-Feng Zhou, Kai-Le Li, Yuan-Yuan Su, Jian-Feng Qiu, Yun-Hu Zhang, Ke-Qin Zhang, Yao He, Xiao-Ping Lu, Shi-Qing Xu
Sexual glands are key sites affected by nanotoxicity, but there is no sensitive assay for measuring reproductive toxicity in animals. The aim of this study was to investigate the toxic effects of cadmium telluride quantum dots (CdTe-QDs) on gonads in a model organism, Bombyx mori. After dorsal vein injection of 0.32 nmol of CdTe-QDs per individual, the QDs passed through the outer membranes of gonads via the generation of ROS in the membranes of spermatocysts and ovarioles, as well as internal germ cells, thereby inducing early germ cell death or malformations via complex mechanisms related to apoptosis and autophagy through mitochondrial and lysosomal pathways...
September 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27618947/in-one-harness-the-interplay-of-cellular-responses-and-subsequent-cell-fate-after-quantum-dot-uptake
#18
Olga Gladkovskaya, Yuri K Gun'ko, Gerard M O'Connor, Vladimir Gogvadze, Yury Rochev
Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models...
October 2016: Nanomedicine
https://www.readbyqxmd.com/read/27615743/the-role-of-exopolymeric-substances-in-the-bioaccumulation-and-toxicity-of-ag-nanoparticles-to-algae
#19
Kaijun Zhou, Yi Hu, Luqing Zhang, Kun Yang, Daohui Lin
Exopolymeric substances (EPS) have an important role in bioaccumulation and toxicity of nanoparticles (NPs) to algae, which warrants specific studies. The interaction of EPS with citrate and polyvinyl pyrrolidone (PVP) coated AgNPs (C-AgNPs and P-AgNPs, respectively) and its roles in bioaccumulation and toxicity of the AgNPs to Chlorella pyrenoidosa were investigated. The amino and aromatic carboxylic groups in the EPS were involved in the EPS-AgNP interactions. Compared with Ag(+), C-AgNPs had comparable total bioaccumulation but greater absorption by intact algae with EPS; P-AgNPs had the smallest total bioaccumulation and were mainly adsorbed on algal surfaces...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27611981/surface-enhanced-raman-scattering-to-evaluate-nanomaterial-cytotoxicity-on-living-cells
#20
Gamze Kuku, Melike Saricam, Farida Akhatova, Anna Danilushkina, Rawil Fakhrullin, Mustafa Culha
The increasing number of reports about false positive or negative results from conventional cytotoxicity assays of nanomaterials (NMs) suggests that more reliable NM toxicity assessment methods should be developed. Here, we report a novel approach for nanotoxicity evaluation based on surface-enhanced Raman spectroscopy (SERS). Three model NMs were tested on two model cell lines and the results were validated by WST-1 cytotoxicity assay and annexin V-FITC/propidium iodide (PI) staining as apoptosis-necrosis assay...
October 4, 2016: Analytical Chemistry
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