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Nanotoxicity

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https://www.readbyqxmd.com/read/28168673/case-study-iii-the-construction-of-a-nanotoxicity-database-the-mod-enp-tox-experience
#1
Hanne Vriens, Dominik Mertens, Renaud Regret, Pinpin Lin, Jean-Pierre Locquet, Peter Hoet
The amount of experimental studies on the toxicity of nanomaterials is growing fast. Interpretation and comparison of these studies is a complex issue due to the high amount of variables possibly determining the toxicity of nanomaterials.Qualitative databases providing a structured combination, integration and quality evaluation of the existing data could reveal insights that cannot be seen from different studies alone. A few database initiatives are under development but in practice very little data is publicly available and collaboration between physicists, toxicologists, computer scientists and modellers is needed to further develop databases, standards and analysis tools...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28168672/compilation-of-data-and-modelling-of-nanoparticle-interactions-and-toxicity-in-the-nanopuzzles-project
#2
Andrea-Nicole Richarz, Aggelos Avramopoulos, Emilio Benfenati, Agnieszka Gajewicz, Nazanin Golbamaki Bakhtyari, Georgios Leonis, Richard L Marchese Robinson, Manthos G Papadopoulos, Mark Td Cronin, Tomasz Puzyn
The particular properties of nanomaterials have led to their rapidly increasing use in diverse fields of application. However, safety assessment is not keeping pace and there are still gaps in the understanding of their hazards. Computational models predicting nanotoxicity, such as (quantitative) structure-activity relationships ((Q)SARs), can contribute to safety evaluation, in line with general efforts to apply alternative methods in chemical risk assessment. Their development is highly dependent on the availability of reliable and high quality experimental data, both regarding the compounds' properties as well as the measured toxic effects...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28107957/methodology-for-monitoring-gold-nanoparticles-and-dissolved-gold-species-in-culture-medium-and-cells-used-for-nanotoxicity-tests-by-liquid-chromatography-hyphenated-to-inductively-coupled-plasma-mass-spectrometry
#3
Sara López-Sanz, Nuria Rodríguez Fariñas, Rosario Serrano Vargas, Rosa Del Carmen Rodríguez Martín-Doimeadios, Ángel Ríos
An analytical methodology based on coupling reversed-phase liquid chromatography (HPLC) to an inductively coupled plasma mass spectrometry (ICP-MS) has been developed for the characterization and identification of gold nanoparticles (AuNPs) and gold dissolved species (Au(3+)) in culture medium (Dulbecco's Modified Eagle Medium, DMEM) and HeLa cells (a human cervical adenocarcinoma cell line) used in nanotoxicity tests. The influence of the culture medium was also studied and the method applied for nanotoxicity tests...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107731/natural-amelioration-of-zinc-oxide-nanoparticle-toxicity-in-fenugreek%C3%A2-trigonella-foenum-gracum-by-arbuscular-mycorrhizal-glomus-intraradices-secretion-of-glomalin
#4
Narges Ghasemi Siani, Seyfollah Fallah, Lok Raj Pokhrel, Ali Rostamnejadi
Owing to rising production and use of engineered nanoparticles (ENPs) in the myriad of consumer applications, ENPs are being released into the environment where their potential fate and effects have remained unclear. With naturally occurring arbuscular mycorrhizal fungus (AMF; Glomus intraradices) in soils, their influence (positive or negative) on ENPs toxicity in plants is not well documented. Herein, we investigated potential influence of AMF on the growth and development in fenugreek (Trigonella foenum-graecum) under varied Zinc oxide nanoparticles (ZnONPs) treatments (0, 125, 250, 375 and 500 μg g(-1))...
January 3, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28105488/effects-of-ceo2-nanoparticles-on-terrestrial-isopod-porcellio-scaber-comparison-of-ceo2-biological-potential-with-other-nanoparticles
#5
Olga Malev, Polonca Trebše, Małgorzata Piecha, Sara Novak, Bojan Budič, Miroslav D Dramićanin, Damjana Drobne
Nano-sized cerium dioxide (CeO2) particles are emerging as an environmental issue due to their extensive use in automobile industries as fuel additives. Limited information is available on the potential toxicity of CeO2 nanoparticles (NPs) on terrestrial invertebrates through dietary exposure. In the present study, the toxic effects of CeO2 NPs on the model soil organism Porcellio scaber were evaluated. Nanotoxicity was assessed by monitoring the lipid peroxidation (LP) level and feeding rate after 14-days exposure to food amended with nano CeO2...
February 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28067384/nanocaged-platforms-modification-drug-delivery-and-nanotoxicity-opening-synthetic-cages-to-release-the-tiger
#6
REVIEW
Parham Sahandi Zangabad, Mahdi Karimi, Fatemeh Mehdizadeh, Hedieh Malekzad, Alireza Ghasemi, Sajad Bahrami, Hossein Zare, Mohsen Moghoofei, Amin Hekmatmanesh, Michael R Hamblin
Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe)...
January 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067319/c-elegans-on-a-chip-for-in-situ-and-in-vivo-ag-nanoparticles-uptake-and-toxicity-assay
#7
Jin Ho Kim, Seung Hwan Lee, Yun Jeong Cha, Sung Jin Hong, Sang Kug Chung, Tai Hyun Park, Shin Sik Choi
Nanomaterials are extensively used in consumer products and medical applications, but little is known about their environmental and biological toxicities. Moreover, the toxicity analysis requires sophisticated instruments and labor-intensive experiments. Here we report a microfluidic chip incorporated with the nematode Caenorhabditis elegans that rapidly displays the changes in body growth and gene expression specifically responsive to the silver nanoparticles (AgNPs). C. elegans were cultured in microfluidic chambers in the presence or absence of AgNPs and were consequently transferred to wedge-shaped channels, which immobilized the animals, allowing the evaluation of parameters such as length, moving distance, and fluorescence from the reporter gene...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28038758/nanosponge-cyclodextrin-polyurethanes-and-their-modification-with-nanomaterials-for-the-removal-of-pollutants-from-waste-water-a-review
#8
REVIEW
Anny Leudjo Taka, Kriveshini Pillay, Xavier Yangkou Mbianda
Water is a worldwide vital resource for sustaining life and due to the pollution of water by different classes of pollutants (inorganic, organic and pathogens), many ongoing studies in water purification remain a critical issue to governments, scientists and industries. The challenge is to develop a water purification technology which will be effective at removing these contaminants simultaneously and reducing their concentrations to ultra low levels from waste water. This review article serves to give an overview on cyclodextrin nanosponge adsorbents which have already been used for water treatment...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28031960/the-melding-of-nanomedicine-in-thrombosis-imaging-and-treatment-a-review
#9
REVIEW
Varvara Karagkiozaki, Foteini Pappa, Despoina Arvaniti, Anestis Moumkas, Dimitrios Konstantinou, Stergios Logothetidis
Thromboembolic diseases constitute a plague in our century, wherein an imbalance of hemostasis leads to thrombus formation and vessels constriction reducing blood flow. Hence, the recent rise of nanomedicine gives birth to advanced diagnostic modalities and therapeutic agents for the early diagnosis and treatment of such diseases. Multimodal nanoagents for the detection of intravascular thrombi and nanovehicles for thrombus-targeted fibrinolytic therapy are few paradigms of nanomedicine approaches to overcome current diagnostic treatment roadblocks and persistent clinical needs...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28024936/nanotoxicity-of-cobalt-induced-by-oxidant-generation-and-glutathione-depletion-in-mcf-7-cells
#10
Mohd Javed Akhtar, Maqusood Ahamed, Hisham A Alhadlaq, Aws Alshamsan
There are very few studies regarding the biological activity of cobalt-based nanoparticles (NPs) and, therefore, the possible mechanism behind the biological response of cobalt NPs has not been fully explored. The present study was designed to explore the potential mechanisms of the cytotoxicity of cobalt NPs in human breast cancer (MCF-7) cells. The shape and size of cobalt NPs were characterized by scanning and transmission electron microscopy (SEM and TEM). The crystallinity of NPs was determined by X-ray diffraction (XRD)...
December 23, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27987725/in-vitro-and-in-vivo-assessment-of-nanotoxicity-of-cds-quantum-dot-aminopolysaccharide-bionanoconjugates
#11
S M de Carvalho, A A P Mansur, H S Mansur, M I M C Guedes, Z I P Lobato, M F Leite
The nanotoxicity of Cd-containing quantum dots (QDs) for biomedical applications is very controversial and not completely understood. In this study, we evaluated the cytotoxicity of surface-biofunctionalized CdS QDs with chitosan directly synthesized via aqueous route at room temperature. These core-shell CdS-chitosan nanoconjugates showed different degrees of cytotoxic responses using MTT cell proliferation assay toward three human cell cultures, human osteosarcoma cell line (SAOS), non-Hodgkin's B cell lymphoma (Toledo), and human embryonic kidney cell line (HEK293T), under three exposure times (1, 3, and 5days) and three colloidal concentrations (10nM, 50nM, and 100nM)...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27982583/standard-cellular-testing-conditions-generate-an-exaggerated-nanoparticle-cytotoxicity-profile
#12
Bella B Manshian, Uwe Himmelreich, Stefaan J Soenen
Cellular internalization of nanoparticles (NPs) is key to many biomedical applications and serves as a model to investigate the potential toxicity of NPs on entire organisms. Large discrepancies between in vitro and in vivo nanotoxicity data however exist, suggesting that cellular systems may not be optimal for predictive in vivo toxicology. Here, we use validated multiparametric high-content imaging protocols to evaluate the impact of common cell culture conditions on NP cytotoxicity studies. The data show that high NP to cell ratios, typical for cellular studies, stress the cells by high endocytosis levels that overstimulate mitochondria, resulting in oxidative stress-mediated mitochondrial damage, which induces autophagy...
December 16, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27951703/modeling-the-hydrophobicity-of-nanoparticles-and-their-interaction-with-lipids-and-proteins
#13
Ali Ramazani, Taraknath Mandal, Ronald G Larson
We present a method of modeling nanoparticle (NP) hydrophobicity using coarse-grained molecular dynamics (CG MD) simulations, and apply this to the interaction of lipids with nanoparticles. To model at a coarse-grained level the wettability or hydrophobicity of a given material, we choose the MARTINI coarse-grained force field, and determine through simulation the contact angles of MARTINI water droplets residing on flat regular surfaces composed of various MARTINI bead types (C1, C2, etc.). Each surface is composed of a single bead type in each of three crystallographic symmetries (FCC, BCC, and HCP)...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27942214/nanotoxicity-emerging-concerns-regarding-nanomaterial-safety-and-occupational-hard-metal-wc-co-nanoparticle-exposure
#14
REVIEW
Andrea L Armstead, Bingyun Li
As the number of commercial and consumer products containing engineered nanomaterials (ENMs) continually rises, the increased use and production of these ENMs presents an important toxicological concern. Although ENMs offer a number of advantages over traditional materials, their extremely small size and associated characteristics may also greatly enhance their toxic potentials. ENM exposure can occur in various consumer and industrial settings through inhalation, ingestion, or dermal routes. Although the importance of accurate ENM characterization, effective dosage metrics, and selection of appropriate cell or animal-based models are universally agreed upon as important factors in ENM research, at present, there is no "standardized" approach used to assess ENM toxicity in the research community...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27920526/in-vitro-inflammatory-effects-of-hard-metal-wc-co-nanoparticle-exposure
#15
Andrea L Armstead, Bingyun Li
Identifying the toxicity of nanoparticles (NPs) is an important area of research as the number of nanomaterial-based consumer and industrial products continually rises. In addition, the potential inflammatory effects resulting from pulmonary NP exposure are emerging as an important aspect of nanotoxicity. In this study, the toxicity and inflammatory state resulting from tungsten carbide-cobalt (WC-Co) NP exposure in macrophages and a coculture (CC) of lung epithelial cells (BEAS-2B) and macrophages (THP-1) at a 3:1 ratio were examined...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27872490/use-of-zebrafish-larvae-as-a-multi-endpoint-platform-to-characterize-the-toxicity-profile-of-silica-nanoparticles
#16
Duc-Hung Pham, Bert De Roo, Xuan-Bac Nguyen, Mattias Vervaele, Angela Kecskés, Annelii Ny, Daniëlle Copmans, Hanne Vriens, Jean-Pierre Locquet, Peter Hoet, Peter A M de Witte
Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity profile is poorly characterized. In this study, we investigated the toxicity of silica nanoparticles with diameters 20, 50 and 80 nm using an in vivo zebrafish platform that analyzes multiple endpoints related to developmental, cardio-, hepato-, and neurotoxicity...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768974/artificially-controlled-degradable-inorganic-nanomaterial-for-cancer-theranostics
#17
Yuxin Liu, Ge Zhang, Quanwei Guo, Liyi Ma, Qi Jia, Lidong Liu, Jing Zhou
Multifunctional nanomaterials for cancer diagnosis and therapy have recently prompted widespread concern. To avoid nanotoxicity, the development of novel degradable functional materials must be our main focus. In this study, we firstly developed ethylenediaminetetraacetic acid calcium disodium salt (EDTA)- and bovine serum albumin (BSA)-capped Mn3O4 nanoparticles (MONPs-BSA-EDTA) as a novel inorganic nanomaterials for multifunctional imaging-guided photothermal therapy, which can be degraded in a progress-controlled way by artificially introduced ascorbic acid...
October 17, 2016: Biomaterials
https://www.readbyqxmd.com/read/27758683/nanocrystal-based-drug-delivery-system-conventional-and-current-scenario
#18
Shreya Thakkar, Viral Shah, Manju Misra, Kiran Kalia
BACKGROUND: Most of the chemical substances which emerge out as potential drug candidates (Active Pharmaceutical Ingredients) are either weak acids or weak bases. Poor aqueous solubility of these drug substances is a common concern. Several R&D centers are focused on developing suitable, economic, simpler and more feasible solubility enhancement techniques for increasing the solubility and thereby bioavailability of such drug substances. Nanocrystals is one of the preferred approaches for solubility enhancement in last few decades...
October 14, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27718008/influence-of-nanotoxicity-on-human-health-and-environment-the-alternative-strategies
#19
Buddolla Viswanath, Sanghyo Kim
Currently, nanotechnology revolutionizing both scientific and industrial community due to their applications in the fields of medicine, environmental protection, energy, and space exploration. Despite of the evident benefits of nanoparticles, there are still open questions about the influence of these nanoparticles on human health and environment. This is one of the critical issues that have to be addressed in the near future, before massive production of nanomaterials. Manufactured nanoparticles, which are finding ever-increasing applications in industry and consumer products fall into the category of emerging contaminants with ecological and toxicological effects on populations, communities and ecosystems...
2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27714104/a-3d-co-culture-microtissue-model-of-the-human-placenta-for-nanotoxicity-assessment
#20
Carina Muoth, Adrian Wichser, Marco Monopoli, Manuel Correia, Nicky Ehrlich, Katrin Loeschner, Audrey Gallud, Melanie Kucki, Liliane Diener, Pius Manser, Wolfram Jochum, Peter Wick, Tina Buerki-Thurnherr
There is increasing evidence that certain nanoparticles (NPs) can overcome the placental barrier, raising concerns on potential adverse effects on the growing fetus. But even in the absence of placental transfer, NPs may pose a risk to proper fetal development if they interfere with the viability and functionality of the placental tissue. The effects of NPs on the human placenta are not well studied or understood, and predictive in vitro placenta models to achieve mechanistic insights on NP-placenta interactions are essentially lacking...
October 6, 2016: Nanoscale
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