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https://www.readbyqxmd.com/read/28886877/functional-sustainability-of-periphytic-biofilms-in-organic-matter-and-cu-2-removal-during-prolonged-exposure-to-tio2-nanoparticles
#1
Junzhuo Liu, Jun Tang, Juanjuan Wan, Chenxi Wu, Bruce Graham, Philip G Kerr, Yonghong Wu
Responses of microbial communities to nanotoxicity in aquatic ecosystems are largely unknown, particularly with respect to relationship between community dynamics and functions. Here, periphytic biofilms were selected as a model of species-rich microbial communities to elucidate their responses when exposed to titanium dioxide nanoparticles (TiO2-NPs). Especially, the relationships between the functions (e.g. organic matter and Cu(2+) removal) and community dynamics after long-term exposure to TiO2-NPs were assessed systematically...
August 30, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28884420/relation-between-biophysical-properties-of-nanostructures-and-their-toxicity-on-zebrafish
#2
REVIEW
C S Martinez, D E Igartúa, M N Calienni, D A Feas, M Siri, J Montanari, N S Chiaramoni, S Del V Alonso, M J Prieto
In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos...
September 7, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28858269/a-review-of-recent-advances-towards-the-development-of-quantitative-structure-activity-relationships-for-metallic-nanomaterials
#3
REVIEW
Guangchao Chen, Martina G Vijver, Yinlong Xiao, Willie J G M Peijnenburg
Gathering required information in a fast and inexpensive way is essential for assessing the risks of engineered nanomaterials (ENMs). The extension of conventional (quantitative) structure-activity relationships ((Q)SARs) approach to nanotoxicology, i.e., nano-(Q)SARs, is a possible solution. The preliminary attempts of correlating ENMs' characteristics to the biological effects elicited by ENMs highlighted the potential applicability of (Q)SARs in the nanotoxicity field. This review discusses the current knowledge on the development of nano-(Q)SARs for metallic ENMs, on the aspects of data sources, reported nano-(Q)SARs, and mechanistic interpretation...
August 31, 2017: Materials
https://www.readbyqxmd.com/read/28854380/the-role-of-antioxidants-in-attenuation-of-caenorhabditis-elegans-lethality-on-exposure-to-tio2-and-zno-nanoparticles
#4
Madhavi Sonane, Nida Moin, Aruna Satish
The exponential increase in the usage of engineered nanoparticles (ENPs) has raised global concerns due to their potential toxicity and environmental impacts. Nano-TiO2 and nano-ZnO have been extensively used in various applications. Thus, there is a need for determining the toxic potentials of ENPs as well as, to develop the possible attenuation method for ENPs toxicity. Both in the in vitro and in vivo systems, exposure to the majority of ENPs have shown Reactive Oxygen Species (ROS) generation, which leads to oxidative stress mediated inflammation, genotoxicity, and cytotoxicity...
August 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/28827674/analyses-in-zebrafish-embryos-reveal-that-nanotoxicity-profiles-are-dependent-on-surface-functionalization-controlled-penetrance-of-biological-membranes
#5
Ilkka Paatero, Eudald Casals, Rasmus Niemi, Ezgi Özliseli, Jessica M Rosenholm, Cecilia Sahlgren
Mesoporous silica nanoparticles (MSNs) are extensively explored as drug delivery systems, but in depth understanding of design-toxicity relationships is still scarce. We used zebrafish (Danio rerio) embryos to study toxicity profiles of differently surface functionalized MSNs. Embryos with the chorion membrane intact, or dechoroniated embryos, were incubated or microinjected with amino (NH2-MSNs), polyethyleneimine (PEI-MSNs), succinic acid (SUCC-MSNs) or polyethyleneglycol (PEG-MSNs) functionalized MSNs. Toxicity was assessed by viability and cardiovascular function...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817263/responses-of-periphyton-to-fe2o3-nanoparticles-a-physiological-and-ecological-basis-for-defending-nanotoxicity
#6
Jun Tang, Ningyuan Zhu, Yan Zhu, Junzhuo Liu, Chenxi Wu, Philip Kerr, Yonghong Wu, Paul K S Lam
The toxic effects of nanoparticles on individual organisms have been widely investigated, while few studies have investigated the effects of nanoparticles on ubiquitous multicommunity microbial aggregates. Here, periphyton as a model of microbial aggregates, was employed to investigate the responses of microbial aggregates exposed continuously to Fe2O3 nanoparticles (5.0 mg L(-1)) for 30 days. The exposure to Fe2O3 nanoparticles results in the chlorophyll (a, b, and c) contents of periphyton increasing and the total antioxidant capacity decreasing...
August 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28799656/review-of-the-effects-of-manufactured-nanoparticles-on-mammalian-target-organs
#7
REVIEW
Tianshu Wu, Meng Tang
Nanotechnology had matured significantly during the last two decades as it has transitioned from bench top science to applied technology. Even though the issue of safety of nanotechnology has been raised nearly one decade ago, the rapid progress in development and use of nanomaterials has not yet been matched by toxicological investigations. Many recent studies have simply outlined the toxic effects of nanoparticles (NPs), but few have systematically addressed their potentially adverse biological effects on target organs...
August 11, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28764786/evaluation-of-the-antibacterial-power-and-biocompatibility-of-zinc-oxide-nanorods-decorated-graphene-nanoplatelets-new-perspectives-for-antibiodeteriorative-approaches
#8
Elena Zanni, Erika Bruni, Chandrakanth Reddy Chandraiahgari, Giovanni De Bellis, Maria Grazia Santangelo, Maurizio Leone, Agnese Bregnocchi, Patrizia Mancini, Maria Sabrina Sarto, Daniela Uccelletti
BACKGROUND: Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. RESULTS: In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa...
August 1, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28758912/spectroscopic-characterization-and-nanosafety-of-ag-modified-antibacterial-leather-and-leatherette
#9
Maria Chiara Sportelli, Rosaria Anna Picca, Federica Paladini, Annarosa Mangone, Lorena Carla Giannossa, Cinzia Di Franco, Anna Lucia Gallo, Antonio Valentini, Alessandro Sannino, Mauro Pollini, Nicola Cioffi
The development of antibacterial coatings is of great interest from both industry and the consumer's point of view. In this study, we characterized tanned leather and polyurethane leatherette, typically employed in the automotive and footwear industries, which were modified by photo-deposition of antibacterial silver nanoparticles (AgNPs). Material surface chemical composition was investigated in detail by X-ray photoelectron spectroscopy (XPS). The material's antibacterial capability was checked against Escherichia coli and Staphylococcus aureus, as representative microorganisms in cross transmissions...
July 29, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28733245/engineered-nanoparticles-for-the-detection-treatment-and-prevention-of-atherosclerosis-how-close-are-we
#10
REVIEW
Luong T H Nguyen, Aristo Muktabar, Jinkai Tang, Vinayak P Dravid, C Shad Thaxton, Subbu Venkatraman, Kee Woei Ng
Atherosclerosis is one of the leading causes of morbidity and mortality worldwide. Nanotechnology has provided the possibility of designing nanoparticles that can translocate through tissues and home in to atherosclerotic plaques to achieve desired diagnostic, therapeutic, theranostic or 'theralivery' outcomes. Although nanomedicine approaches have demonstrated exciting possibilities, clinical reality is still distant and challenges are aplenty, such as specificity of targeting and nanotoxicity. Nevertheless, developments in formulations, delivery strategies and experimental models over the coming years will generate new knowledge to define the true potential of this field...
July 18, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28722443/quantum-dot-nanotoxicity-investigations-using-human-lung-cells-and-toxor-electrochemical-enzyme-assay-methodology
#11
Tony O'Hara, Brian Seddon, Andrew O'Connor, Siobhán McClean, Baljit Singh, Emmanuel Iwuoha, Xolile Fuku, Eithne Dempsey
Recent studies have suggested that certain nanomaterials can interfere with optically based cytotoxicity assays resulting in underestimations of nanomaterial toxicity. As a result there has been growing interest in the use of whole cell electrochemical biosensors for nanotoxicity applications. Herein we report application of an electrochemical cytotoxicity assay developed in house (TOXOR) in the evaluation of toxic effects of mercaptosuccinic acid capped cadmium telluride quantum dots (MSA capped CdTe QDs), toward mammalian cells...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721038/toxicity-based-toxicokinetic-toxicodynamic-assessment-of-bioaccumulation-and-nanotoxicity-of-zerovalent-iron-nanoparticles-in-caenorhabditis-elegans
#12
Ying-Fei Yang, Yi-Jun Lin, Chung-Min Liao
Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe(0)) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe(0)NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28704975/current-knowledge-on-the-use-of-computational-toxicology-in-hazard-assessment-of-metallic-engineered-nanomaterials
#13
REVIEW
Guangchao Chen, Willie Peijnenburg, Yinlong Xiao, Martina G Vijver
As listed by the European Chemicals Agency, the three elements in evaluating the hazards of engineered nanomaterials (ENMs) include the integration and evaluation of toxicity data, categorization and labeling of ENMs, and derivation of hazard threshold levels for human health and the environment. Assessing the hazards of ENMs solely based on laboratory tests is time-consuming, resource intensive, and constrained by ethical considerations. The adoption of computational toxicology into this task has recently become a priority...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28689990/graphene-oxide-nanosheets-in-complex-with-cell-penetrating-peptides-for-oligonucleotides-delivery
#14
Moataz Dowaidar, Hani Nasser Abdelhamid, Mattias Hällbrink, Xiaodong Zou, Ülo Langel
A new strategy for gene transfection using the nanocarrier of cell penetrating peptides (CPPs; PepFect14 (PF14) or PepFect14 (PF14) (PF221)) in complex with graphene oxide (GO) is reported. GO complexed with CPPs and plasmid (pGL3), splice correction oligonucleotides (SCO) or small interfering RNA (siRNA) are performed. Data show adsorption of CPPs and oligonucleotides on the top of the graphenic lamellar without any observed change of the particle size of GO. GO mitigates the cytotoxicity of CPPs and improves the material biocompatibility...
September 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28689059/epigenetic-modulations-in-nanoparticle-mediated-toxicity
#15
Belinda Shu Ee Wong, Qidong Hu, Gyeong Hun Baeg
The increasing application of nanoparticles in healthcare and consumer products has made them ever present in our lives. However, constant exposure to these nanoparticles has raised concerns regarding their adverse side effects on human health, signifying the great importance of nanotoxicity studies. Indeed, extensive in vitro and in vivo studies in this field have provided valuable insights into the potential cytotoxicity and genotoxicity induced by nanoparticles. Interestingly, there is a growing body of evidence that nanoparticles can also induce epigenetic changes...
July 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28687867/effect-of-multi-walled-carbon-nanotubes-on-metabolism-and-morphology-of-filamentous-green-microalgae
#16
Michele Munk, Humberto M Brandão, Claude Yéprémian, Alain Couté, Luiz O Ladeira, Nádia R B Raposo, Roberta Brayner
Multi-walled carbon nanotubes (MWCNTs) have potential applications in the industrial, agricultural, pharmaceutical, medical, and environmental remediation fields. However, many uncertainties exist regarding the environmental implications of engineered nanomaterials. This study examined the effect of the MWCNTs on metabolic status and morphology of filamentous green microalgae Klebsormidium flaccidum. Appropriate concentrations of MWCNT (1, 50, and 100 μg mL(-1)) were added to a microalgal culture in the exponential growth phase and incubated for 24, 48, 72, and 96 h...
July 7, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28673184/toxicogenomics-of-iron-oxide-nanoparticles-in-the-nematode-c-elegans
#17
Laura Gonzalez-Moragas, Si-Ming Yu, Núria Benseny-Cases, Stephen Stürzenbaum, Anna Roig, Anna Laromaine
We present a mechanistic study of the effect of iron oxide nanoparticles (SPIONs) in Caenorhabditis elegans combining a genome-wide analysis with the investigation of specific molecular markers frequently linked to nanotoxicity. The effects of two different coatings were explored: citrate, an anionic stabilizer, and bovine serum albumin, as a pre-formed protein corona. The transcriptomic study identified differentially expressed genes following an exposure to SPIONs. The expression of genes involved in oxidative stress, metal detoxification response, endocytosis, intestinal integrity and iron homeostasis was quantitatively evaluated...
July 4, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28620743/understanding-the-interactions-of-human-follicle-stimulating-hormone-with-single-walled-carbon-nanotubes-by-molecular-dynamics-simulation-and-free-energy-analysis
#18
Yasaman Mahmoodi, Faramarz Mehrnejad, Khosrow Khalifeh
Interactions of carbon nanotubes (CNTs) and blood proteins are of interest for nanotoxicology and nanomedicine. It is believed that the interactions of blood proteins and glycoproteins with CNTs may have important biological effects. In spite of many experimental studies of single-walled carbon nanotubes (SWCNT) and glycoproteins with different methods, little is known about the atomistic details of their association process or of structural alterations occurring in adsorbed glycoproteins. In this study, we have applied molecular dynamics simulation to investigate the interaction of follicle stimulating hormone (hFSH) with SWCNT...
June 15, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28614664/molecular-mechanisms-of-developmental-toxicity-induced-by-graphene-oxide-at-predicted-environmental-concentrations
#19
Xingli Zhang, Qixing Zhou, Wei Zou, Xiangang Hu
Developmental toxicity is a critical issue in nanotoxicity. However, very little is known about the effects of graphene oxide (GO, a widely used carbon material) at predicted environmental concentrations on biological development or the specific molecular mechanisms. The present study established that the development of zebrafish embryos exposed to trace concentrations (1-100 μg/L) of GO was impaired because of DNA modification, protein carbonylation and excessive generation of reactive oxygen species (ROS), especially the superoxide radical...
June 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28605996/in-vitro-exposure-of-bull-sperm-cells-to-dmsa-coated-maghemite-nanoparticles-does-not-affect-cell-functionality-or-structure
#20
Denise Ferreira Caldeira, Fernanda Paulini, Renata Carvalho Silva, Ricardo Bentes de Azevedo, Carolina Madeira Lucci
Magnetic nanoparticles can be used in different areas of biology. It is therefore important to know the effects of such nanomaterials on germline cells as they may traverse the blood-testis barrier. This work aimed to evaluate the response of bull sperm after exposure to a magnetic fluid containing DMSA-coated maghemite nanoparticles (MNP-DMSA) in order to determine nanotoxicity. Bull sperm was incubated with MNP-DMSA at final concentrations of 0.06, 0.03 or 0.015 mg Fe/mL. Sperm kinetics, plasma membrane integrity and acrosome reaction were evaluated over a four-hour incubation period...
June 12, 2017: International Journal of Hyperthermia
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