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Peripheral neuropathy

Alise Kalteniece, Maryam Ferdousi, Shazli Azmi, Andrew Marshall, Handrean Soran, Rayaz A Malik
Purpose: The purpose of this study was to assess the relationship between corneal keratocyte density (KD) and corneal nerve damage in patients with and without diabetic peripheral neuropathy. Methods: Eighty-six patients with type 1 and type 2 diabetes and 21 age-matched control subjects underwent assessment of the neuropathy disability score, quantitative sensory testing, electrophysiology, and corneal confocal microscopy and were divided into those without (DN-) (n = 22) and with (DN+) (n = 64) diabetic neuropathy...
July 2, 2018: Investigative Ophthalmology & Visual Science
Le-Nyu Gao, Bing Zhong, Yong Wang
RATIONALE: Hansen disease is an infectious chronic disease with various clinical manifestations. Its joint performance may easily mimic rheumatoid arthritis. PATIENT CONCERNS: We report a case of a 57-year-old woman diagnosed with Hansen disease 10 years ago, who suffered from joints swelling, pain and joints deformities of both hands for 19 years. The skin on the hands showed rashes, thickening, desquamation and chapping, with both thenar muscles atrophy. She also had severe hypoalgesia of the whole body, and morning stiffness for one hour...
July 2018: Medicine (Baltimore)
Ji Seon Jeong, Ha Yeon Kim, Byung Seop Shin, Ae Ryoung Lee, Ji Hyun Yoon, Tae Soo Hahm, Ja Eun Lee
BACKGROUND: Interleukin 2 (IL-2) influences the development and severity of pain due to its antinociceptive and immunomodulatory effects. Its production is influenced by the increased expression of c-Cbl (Casitas B-lineage lymphoma proto-oncogene) and Cbl-b E3 ubiquitin ligases. We evaluated the effects on IL-2-mediated changes in c-Cbl and Cbl-b expression in a rat model of chronic neuropathic pain. METHODS: Peripheral neuropathy was induced in adult male Sprague-Dawley rats weighing 250-300 g by chronic spinal nerve ligation...
July 18, 2018: BMC Anesthesiology
Haiyan Pan, Yuanlin Ding, Ning Yan, Yaxin Nie, Mei Li, Linyan Tong
Type 1 diabetes (T1DM) affects approximately 1 in 500 children. Diabetic peripheral neuropathy (DPN) is the most common form of peripheral neuropathy in diabetes and is a significant risk factor for serious pathological change. It is difficult and costly to treat DPN and although there have been several pivotal trials. The development of new drugs to treat DPN remains a high priority. Trehalose is a naturally occurring disaccharide, which is indicated to prevent maternal type 1 diabetes-induced neural tube defects...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marilia Brasil Xavier, Mariana Garcia Borges do Nascimento, Keila de Nazare Madureira Batista, Danusa Neves Somensi, Fernando Octavio Machado Juca Neto, Thomaz Xavier Carneiro, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett
BACKGROUND: The geographical overlap of HIV (human immunodeficiency virus) and leprosy infection has become increasingly frequent and worrying, bringing many clinical issues. Peripheral neuropathy is very frequent in leprosy because of the predilection of its etiologic agent by Schwann cells of the peripheral nervous system, and it also affects individuals with HIV as one of the most common neurological manifestations. METHODOLOGY/PRINCIPAL FINDINGS: The present study compared a cohort of 63 patients diagnosed with leprosy and coinfected with HIV with a cohort of 64 patients with leprosy alone, who were followed at the outpatient clinic of the Nucleus of Tropical Medicine of the Federal University of Pará, Brazil...
July 18, 2018: PLoS Neglected Tropical Diseases
Juan Lv, Lanxiu Cao, Rui Zhang, Fu Bai, Pengfei Wei
PURPOSE: To investigate the specific molecular mechanisms and effects of curcumin derivative J147 on diabetic peripheral neuropathy (DPN). METHODS: We constructed streptozotocin (STZ)-induced DPN rat models to detected mechanical withdrawal threshold (MWT) in vivo using Von Frey filaments. In vitro, we measured cell viability and apoptosis, adenosine 5'-monophosphate-activated protein kinase (AMPK) and transient receptor potential A1 (TRPA1) expression using MTT, flow cytometry, qRT-PCR and western blot...
June 2018: Acta Cirúrgica Brasileira
Qingbin Shi, Xiuying Cai, Guixiang Shi, Xingle Lv, Jinping Yu, Feng Wang
PURPOSE: To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. METHODS: The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincristine induced increased sensitivity to mechanical stimulation was measured by von Frey hair test 7 and 14 days after intraperitoneal administration of 0...
June 2018: Acta Cirúrgica Brasileira
Fuyuan Liao, Ruopeng An, Fang Pu, Stephanie Burns, Sa Shen, Yih-Kuen Jan
The objectives of this study were to examine the effectiveness of different types of exercise on risk factors of diabetic foot ulcers, including glycated hemoglobin (HbA1c), peripheral arterial disease (PAD), and diabetic peripheral neuropathy, in people with type 2 diabetes mellitus (T2DM). PubMed, Web of Science, Cochrane Library, Scopus, and CINAHL were searched from inception to January 2018 for relevant articles. Eligible studies were randomized controlled trials (RCTs) that examined effects of exercise on the selected risk factors...
July 16, 2018: American Journal of Physical Medicine & Rehabilitation
Wenxin Luo, Zhoufeng Wang, Panwen Tian, Weimin Li
BACKGROUND: Significant improvement in survival outcome with the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors has been shown in advanced non-small cell lung cancer (NSCLC) patients compared with chemotherapy. However, the full spectrum of toxic events of PD-1/PD-L1 inhibitors was not well characterized. We conducted a comprehensive meta-analysis to state the safety profile of PD-1/PD-L1 inhibitors in NSCLC, and identify the exact incidence and relative risk (RR) of both summary and detailed AEs...
July 17, 2018: Journal of Cancer Research and Clinical Oncology
E Dianne Pulte, Jonathon Vallejo, Donna Przepiorka, Lei Nie, Ann T Farrell, Kirsten B Goldberg, Amy E McKee, Richard Pazdur
On July 11, 2017, the Food and Drug Administration granted approval for blinatumomab for the treatment of relapsed or refractory (R/R) precursor B-cell acute lymphoblastic leukemia (ALL). Blinatumomab is a bispecific CD19-directed CD3 T-cell engager. The basis for the approval included results from two clinical trials, TOWER and ALCANTARA. TOWER, a randomized trial comparing overall survival in patients with Philadelphia chromosome (Ph)-negative R/R ALL receiving blinatumomab versus standard-of-care (SOC) chemotherapy, demonstrated a hazard ratio of 0...
July 17, 2018: Oncologist
Patrick J Howlett, Anna R Walder, Durodami R Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N'jai, Colin S Brown, Foday Sahr, Foday Sesay, Jonathon M Read, Paul J Steptoe, Nicholas A V Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F Deen, Tom Solomon, Malcolm G Semple, Janet T Scott
We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions...
August 2018: Emerging Infectious Diseases
Lorena Rosca, Viviane Robert-Boire, Jean-François Delisle, Yvan Samson, Sébastien Perreault
BACKGROUND: Pediatric low-grade gliomas (LGG) represent 30-50% of central nervous system pediatric tumors. Over the last decades, the combination of carboplatin and vincristine (CV) has become the first line of treatment in most centers. In a large clinical trial where the efficacy of CV was compared to another regimen, 19% presented grade III neurotoxicity. Despite the fact that CV therapy is widely used for pediatric patients with LGG, no study has reported detailed neurological adverse events and outcome with this treatment regimen...
July 16, 2018: Pediatric Blood & Cancer
Amrita Sil, Hrishikesh Kumar, Rahul Deb Mondal, Sidharth Sankar Anand, Anirban Ghosal, Ashis Datta, Sandesh V Sawant, Vaibhavi Kapatkar, Ganesh Kadhe, Sameer Rao
Background: Vitamin B12 deficiency has been associated with peripheral neuropathy, loss of sensation in the peripheral nerves, and weakness in the lower extremities. Methylcobalamin is the most effective analogue of vitamin B12 used to treat or prevent the complications associated with vitamin B12 deficiency. The current study aimed to compare the serum cobalamin levels after administration of two different regimes of methylcobalamin in peripheral neuropathy patients. Methods: The present study was a prospective, randomized, comparative study...
July 2018: Korean Journal of Pain
Zhixue Wang, Fanghua Qi, Yangang Cui, Lin Zhao, Xiaogang Sun, Wei Tang, Pingping Cai
Numerous studies have indicated that in cancer treatment Chinese herbal medicines in combination with chemo-, radio-, or targeted-therapy can be used to enhance the efficacy of and diminish the side effects and complications caused by these therapies. Therefore, an understanding of Chinese herbal medicines is needed by physicians and other health care providers. This review provides an update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics. First, some Chinese herbal medicines (e...
2018: Bioscience Trends
Olivier Audet, Hung Tien Bui, Maxime Allisse, Alain-Steve Comtois, Mario Leone
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neuromuscular disorder caused by the mutation of the SACS gene. Clinical symptoms of this disease include progressive ataxia, spasticity, and peripheral neuropathy. Similar to other neuromuscular disorders, these patients are prone to physical deconditioning which may lead to a loss of functional capacity. This paper aims to evaluate the impact of a training program on the physical fitness and the functional capacity of ARSACS patients...
July 15, 2018: Bioscience Trends
Sungsu Kim, Jason C Maynard, Amy Strickland, Alma L Burlingame, Jeffrey Milbrandt
Schwann cells (SCs), the glia of the peripheral nervous system, play an essential role in nerve regeneration. Upon nerve injury, SCs are reprogrammed into unique "repair SCs," and these cells remove degenerating axons/myelin debris, promote axonal regrowth, and ultimately remyelinate regenerating axons. The AP-1 transcription factor JUN is promptly induced in SCs upon nerve injury and potently mediates this injury-induced SC plasticity; however, the regulation of these JUN-dependent SC injury responses is unclear...
July 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
Katie E Chatwin, Caroline A Abbott, Prabhav N Reddy, Frank L Bowling, Andrew J M Boulton, Neil D Reeves
High plantar pressure as a result of diabetic peripheral neuropathy is often reported as a major risk factor for ulceration. However, previous studies are confined to laboratories with equipment limited by cables, reducing the validity of measurements to daily life. The participant concerned in this case report was wearing an innovative plantar pressure feedback system as part of a wider study. The system allows for continuous plantar pressure monitoring and provides feedback throughout all activities of daily living...
June 2018: International Journal of Lower Extremity Wounds
Mathilde Duchesne, Olivier Roussellet, Thierry Maisonobe, Nathalie Gachard, David Rizzo, Marine Armand, Karine Viala, Laurence Richard, Manuela Delage-Corre, Arnaud Jaccard, Philippe Corcia, Jean-Michel Vallat, Laurent Magy
Infiltration of the peripheral nervous system (PNS) by lymphoma, called neurolymphomatosis, is a rare condition among the spectrum of lymphoma-associated neuropathies; its diagnosis is challenging. Cerebrospinal fluid (CSF) analysis is of great value, but nerve biopsy (NB) may be necessary to prove invasion by malignant cells. Clonality polymerase chain reaction (PCR)-based analysis is a validated method in the diagnosis of hematological malignancies, but there are very little data on its diagnostic yield on NB samples...
June 23, 2018: Journal of Neuropathology and Experimental Neurology
Emad Khalilzadeh, Farzin Azarpey, Reza Hazrati, Gholamreza Vafaei Saiah
It seems that histamine release in the site of neuronal injury could contribute to the neuropathic pain mechanism. In the present study, we investigated the anti-allodynic effects of chronic administration of different classes of histamine H1 and H2 receptor antagonists on neuropathic nociceptive behavior following tibial nerve transection (TNT) in rats. Peripheral neuropathy was induced by TNT surgery. We performed acetone tests (AT) to record cold allodynia, Von Frey tests (VFT) to measure mechanical allodynia, double plate test (DPT) to evaluate thermal place preference/avoidance and open field test (OFT) for evaluation of animal activity...
July 13, 2018: European Journal of Pharmacology
Frank Liaw, Odhrán Murray, Yan Yu Tan, Timothy Hems
Background: Diabetic peripheral neuropathy puts patients at increased risk of acute injury by foreign bodies and also contributes to delayed presentation and diagnosis. Case report: We describe a 57-year-old patient with poorly controlled type 1 diabetes who presented with a three-week history of worsening swelling and erythema in the metacarpophalangeal joint of his left thumb. He denied any previous trauma or injury and was initially treated with intravenous antibiotics...
2018: Open Orthopaedics Journal
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