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Colon cancer

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https://www.readbyqxmd.com/read/28738498/microrna-299-3p-suppresses-proliferation-and-invasion-by-targeting-vegfa-in-human-colon-carcinoma
#1
Jia-Yong Wang, Jin-Bo Jiang, Yuan Li, Yan-Lei Wang, Yong Dai
Accumulating evidences have shown that microRNAs (miRNAs) are vital regulators and possess huge capabilities in post-transcriptional control. Although a large number of miRNAs have been identified to be dysregulated in human cancers especially in colon cancer, our understandings of the function of most miRNAs are still largely limited. In this study, we have demonstrated that miR-299-3p plays a critical role in suppressing colon carcinoma progression by targeting Vascular Endothelial Growth Factor A (VEGFA)...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28737825/combination-of-rapamycin-and-garlic-derived-s-allylmercaptocysteine-induces-colon-cancer-cell-apoptosis-and-suppresses-tumor-growth-in-xenograft-nude-mice-through-autophagy-p62-nrf2-pathway
#2
Siying Li, Guang Yang, Xiaosong Zhu, Lin Cheng, Yueyue Sun, Zhongxi Zhao
The natural plant-derived product S-allylmercapto-cysteine (SAMC) has been studied in cancer therapy as a single and combination chemotherapeutic agent. The present study was employed to verify the combination use of SAMC and rapamycin that is the mTOR inhibitor with anticancer ability but has limited efficacy due to drug resistance, and to explore the underlying mechanisms. We combined rapamycin and SAMC for colorectal cancer treatment in the HCT‑116 cancer cells and a xenograft murine model. The in vivo study was established by xenografting HCT‑116 cells in BALB/c nude mice...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737648/who-is-responsible-for-what-happens-before-during-and-after-colonoscopy-results-of-a-national-survey-of-primary-care-physicians
#3
Andrew J Read, Arlene Weissman, Philip S Schoenfeld, Seema Saini, Stacy B Menees, Sameer D Saini
BACKGROUND AND AIMS: Primary care providers (PCPs) play a critical role in colon cancer screening by initiating referrals to gastroenterologists for colonoscopy, but little is known about their role in pre-colonoscopy bowel preparation selection and pre-colonoscopy follow-up care. This study aimed to better understand coordination of care between PCPs and gastroenterologists as well as the current availability of "open-access" screening colonoscopy. METHODS: A multiple-choice survey was developed to assess PCPs' experiences with open-access colonoscopy, their involvement in the pre-colonoscopy process, and follow-up after colonoscopy...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28737074/intraoperative-tumor-perforation-is-associated-with-decreased-5-year-survival-in-colon-cancer-a-nationwide-database-study
#4
N S Bundgaard, V O Bendtsen, P Ingeholm, U H Seidelin, K H Jensen
BACKGROUND: It is a widely held belief that intraoperative tumor perforation in colon cancer impairs survival and causes local recurrence, although the prognostic importance remains unclear. AIM: The aim of this study was to assess the effect of unintended intraoperative tumor perforation on postoperative mortality and long-term survival. MATERIAL AND METHODS: This national cohort study was based on data from a prospectively maintained nationwide colorectal cancer database...
March 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28736986/adolescent-body-mass-index-and-risk-of-colon-and-rectal-cancer-in-a-cohort-of-1-79-million-israeli-men-and-women-a-population-based-study
#5
Zohar Levi, Jeremy D Kark, Lior H Katz, Gilad Twig, Estela Derazne, Dorit Tzur, Yaara Leibovici Weissman, Adi Leiba, Irena Lipshiez, Lital Keinan Boker, Arnon Afek
BACKGROUND: This study examined the association between the body mass index (BMI) in late adolescence and the risk of colon and rectal cancer. METHODS: This study analyzed a cohort of 1,087,358 Jewish men and 707,212 Jewish women who underwent health examinations at the ages of 16 to 19 years between 1967 and 2002 and were followed by linkage to the national cancer registry up to 2012. Cox regression was used to estimate hazard ratios (HRs) for cancer according to age- and sex-adjusted BMI percentiles from the US Centers for Disease Control and Prevention (overweight, 85th percentile to <95th percentile; obesity, ≥95th percentile)...
July 24, 2017: Cancer
https://www.readbyqxmd.com/read/28736844/newly-designed-silica-containing-redox-nanoparticles-for-oral-delivery-of-novel-top2-catalytic-inhibitor-for-treating-colon-cancer
#6
Long Binh Vong, Shinya Kimura, Yukio Nagasaki
Although oral drug delivery is the most common route of drug administration, the conventional polymeric nanocarriers exhibit a low drug loading capacity and low stability in the gastrointestinal (GI) environments. In this study, a newly designed silica-containing redox nanoparticle (siRNP) with reactive oxygen species (ROS) scavenging capacity is developed as an ideal oral nanocarrier for a novel hydrophobic anticancer compound BNS-22 to treat colitis-associated colon cancer in vivo. Crosslinking of silica moieties significantly enhances the stability under acidic conditions and improves BNS-22 loading capacity of siRNP compared to the conventional redox nanoparticle...
July 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28736641/bone-marrow-tolerance-during-postoperative-chemotherapy-in-colorectal-carcinomas
#7
Neil B Newman, Rebecca A Moss, Nell Maloney-Patel, Kristen Donohue, Teresa V Brown, Michael J Nissenblatt, Shou-En Lu, Salma K Jabbour
BACKGROUND: This study seeks to quantify and compare bone marrow tolerance during postoperative chemotherapy therapy between rectal cancer vs. colon cancer patients. During rectal cancer treatment, patients receive neoadjuvant chemoradiation (CRT) irradiation which can exacerbate the hematologic toxicity (HT) via incidental irradiation of the pelvic bone marrow (PBM) during myelosuppressive postoperative chemotherapy. In contrast, colon cancer patients receive the same postoperative myelosuppressive chemotherapy but do not routinely receive preoperative chemoradiation therapy...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736640/systematic-review-and-a-meta-analysis-of-hospital-and-surgeon-volume-outcome-relationships-in-colorectal-cancer-surgery
#8
Ya Ruth Huo, Kevin Phan, David L Morris, Winston Liauw
BACKGROUND: Numerous hospitals worldwide are considering setting minimum volume standards for colorectal surgery. This study aims to examine the association between hospital and surgeon volume on outcomes for colorectal surgery. METHODS: Two investigators independently reviewed six databases from inception to May 2016 for articles that reported outcomes according to hospital and/or surgeon volume. Eligible studies included those in which assessed the association hospital or surgeon volume with outcomes for the surgical treatment of colon and/or rectal cancer...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736637/primary-and-acquired-resistance-to-biologic-therapies-in-gastrointestinal-cancers
#9
REVIEW
Sam J Lubner, Nataliya V Uboha, Dustin A Deming
Improvements in the understanding of cancer biology have led to therapeutic advances in the treatment of gastrointestinal cancers. Drugs which target the vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) pathways have led the way in colon cancer. Monoclonal antibodies (mAbs) such as bevacizumab, ramucirumab, cetuximab, and panitumumab, have improved progression free survival and overall survival (OS) for colorectal cancers and were quickly adopted. Human epidermal growth factor receptor 2 (HER2) has demonstrated significant benefit for gastroesophageal cancers and in the setting of HER2 amplification, trastuzumab in combination with chemotherapy has become the standard of care...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28735743/exposure-to-meat-derived-carcinogens-and-bulky-dna-adduct-levels-in-normal-appearing-colon-mucosa
#10
Vikki Ho, Vanessa Brunetti, Sarah Peacock, Thomas E Massey, Roger W L Godschalk, Frederik J van Schooten, Janet E Ashbury, Stephen J Vanner, Will D King
INTRODUCTION: Meat consumption is a risk factor for colorectal cancer. This research investigated the relationship between meat-derived carcinogen exposure and bulky DNA adduct levels, a biomarker of DNA damage, in colon mucosa. METHODS: Least squares regression was used to examine the relationship between meat-derived carcinogen exposure (PhIP and meat mutagenicity) and bulky DNA adduct levels in normal-appearing colon tissue measured using (32)P-postlabelling among 202 patients undergoing a screening colonoscopy...
September 2017: Mutation Research
https://www.readbyqxmd.com/read/28735581/independent-associations-of-dairy-and-calcium-intakes-with-colorectal-cancers-in-the-adventist-health-study-2-cohort
#11
Yessenia Tantamango-Bartley, Synnove F Knutsen, Karen Jaceldo-Siegl, Jing Fan, Andrew Mashchak, Gary E Fraser
OBJECTIVE: Results associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes. DESIGN: Adventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR)...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28735041/self-assembled-polypeptide-nanoparticles-for-intracellular-irinotecan-delivery
#12
N N Zashikhina, M V Volokitina, V A Korzhikov-Vlakh, I I Tarasenko, A Lavrentieva, T Scheper, E Rhuel, R V Orlova, T B Tennikova, E G Korzhikova-Vlakh
In this research poly(l-lysine)-b-poly(l-leucine) (PLys-b-PLeu) polymersomes were developed. It was shown that the size of nanoparticles depended on pH of self-assembly process and varied from 180 to 650nm. The biodegradation of PLys-b-PLeu nanoparticles was evaluated using in vitro polypeptide hydrolysis in two model enzymatic systems, as well as in human blood plasma. The experiments of the visualization of cellular uptake of rhodamine 6g-loaded and fluorescein-labeled nanoparticles were carried out, which approved the possibility of their penetration into the cells...
July 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28734498/surgical-site-infection-reduction-bundle-in-patients-with-gynecologic-cancer-undergoing-colon-surgery
#13
Maria B Schiavone, Lea Moukarzel, Kam Leong, Qin C Zhou, Anoushka M Afonso, Alexia Iasonos, Kara Long Roche, Mario M Leitao, Dennis S Chi, Nadeem R Abu-Rustum, Oliver Zivanovic
OBJECTIVE: Surgical site infections (SSIs) can lead to substantial morbidity, prolonged hospitalization, increased costs, and death in patients undergoing colorectal procedures. We sought to investigate the effect of using an SSI reduction bundle on the rate of SSIs in gynecologic cancer patients undergoing colon surgery. METHODS: We identified all gynecologic cancer patients who underwent colon resection at our institution from 2014 to 2016, during which time a service-wide SSI reduction bundle was introduced...
July 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28733896/precancerous-acf-induction-affects-their-regional-distribution-forsaking-oxidative-stress-implication-in-1-2-dimethylhydrazine-induced-colon-carcinogenesis-model
#14
Hichem Moulahoum, Andras-Laszlo Nagy, Bahia Djerdjouri, Simona Clichici
Colon cancer is thought to develop in a stepwise fashion. In this study, the relationship between aberrant crypt foci (ACF) regional distribution and oxidative stress evolution was studied in a murine model of initial colon carcinogenesis induced by dimethylhydrazine (DMH). Mice were given 2 weekly subcutaneous injections of DMH (20 mg/kg) and killed at the 10th, 12th or 14th week. ACF was scored for number, distribution and crypt multiplicity after methylene-blue coloration and histologically analyzed afterwards...
July 21, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28733869/bmi-is-a-risk-factor-for-colorectal-cancer-mortality
#15
Aasma Shaukat, Allison Dostal, Jeremiah Menk, Timothy R Church
BACKGROUND: The relationship between dietary and lifestyle risk factors and long-term mortality from colorectal cancer is poorly understood. Several factors, such as obesity, intakes of red meat, and use of aspirin, have been reported to be associated with risk of colorectal cancer mortality, though these findings have not been replicated in all studies to date. METHODS: In the Minnesota Colon Cancer Control Study, 46,551 participants 50-80 years old were randomly assigned to usual care (control) or annual or biennial screening by fecal occult blood testing...
July 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28733788/isolated-metachronous-splenic-metastasis-from-colon-cancer-possible-explanations-for-this-rare-entity
#16
Fabio Rizzo, Sergio Calamia, Giovanni Mingoia, Fabio Fulfaro, Nello Grassi, Calogero Cipolla
No abstract text is available yet for this article.
July 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28733739/variation-and-treatment-of-vessels-in-laparoscopic-right-hemicolectomy
#17
Kai Ye, Jianan Lin, Yafeng Sun, Yiyang Wu, Jianhua Xu, Songbing He
BACKGROUND: With the introduction of complete mesocolic excision (CME) and the application of laparoscopic technique, surgery for colon cancer has become more standardized and the curative effect has improved [1]. The key points in laparoscopic right hemicolectomy are high ligation of main vessels and root dissection of lymph nodes. The wide range of variations in vascular architecture and intraoperative bleeding are common causes of prolonged surgical time, wound hemorrhage, and even transfer to the opening operation...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28733526/investigation-of-methylenetetrahydrofolate-reductase-tagging-polymorphisms-with-colorectal-cancer-in-chinese-han-population
#18
Sheng Zhang, Shuchen Chen, Yu Chen, Mingqiang Kang, Chao Liu, Hao Qiu, Yafeng Wang, Weifeng Tang
The aim of this case-control study was to assess the relationship between the tagging polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene and the susceptibility to colorectal cancer (CRC) in a Chinese Han population. A custom-by-design 48-Plex SNPscan Kit was used to determine the genotypes of MTHFR rs3753584 T>C, rs9651118 T>C, rs1801133 G>A, rs4846048 A>G and rs4845882 G>A polymorphisms in 387 CRC patients and 1,536 non-cancer controls. The results revealed that MTHFR rs1801133 G>A polymorphism was associated with a decreased risk of overall CRC...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733525/ackr3-expression-on-diffuse-large-b-cell-lymphoma-is-required-for-tumor-spreading-and-tissue-infiltration
#19
Viola Puddinu, Sabrina Casella, Egle Radice, Sylvia Thelen, Stefan Dirnhofer, Francesco Bertoni, Marcus Thelen
Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of the chemokine system in these processes is assumed as it is known as a critical regulator of the metastatic process in cancer. The atypical chemokine receptor 3 (ACKR3), which does not couple to G-proteins and does not mediate cell migration, acts as a scavenger for CXCL11 and CXCL12, interfering with the tumor homing CXCL12/CXCR4 axis...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733262/cost-effectiveness-of-high-performance-biomarker-tests-vs-fecal-immunochemical-test-for-non-invasive-colorectal-cancer-screening
#20
Iris Lansdorp-Vogelaar, S Lucas Goede, Linda J W Bosch, Veerle Melotte, Beatriz Carvalho, Manon van Engeland, Gerrit A Meijer, Harry J de Koning, Marjolein van Ballegooijen
BACKGROUND: Biomarker assays could increase the accuracy of non-invasive detection of colorectal cancer (CRC); fecal immunochemical tests (FITs) are estimated to miss 27%-47% of CRCs and 70%-80% of advanced adenomas per round of screening. We investigated the conditions under which biomarker screens would be cost-effective compared to FIT screens of average risk individuals. METHODS: We used the MISCAN-colon microsimulation model to estimate the effects of various CRC screening test characteristics on life years gained (LYG) and costsBiomarker assays could increase the accuracy of non-invasive detection of colorectal cancer (CRC); fecal immunochemical tests (FITs) are estimated to miss 27%-47% of CRCs and 70%-80% of advanced adenomas per round of screening...
July 18, 2017: Clinical Gastroenterology and Hepatology
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