keyword
https://read.qxmd.com/read/38177193/fishglob_data-an-integrated-dataset-of-fish-biodiversity-sampled-with-scientific-bottom-trawl-surveys
#21
JOURNAL ARTICLE
Aurore A Maureaud, Juliano Palacios-Abrantes, Zoë Kitchel, Laura Mannocci, Malin L Pinsky, Alexa Fredston, Esther Beukhof, Daniel L Forrest, Romain Frelat, Maria L D Palomares, Laurene Pecuchet, James T Thorson, P Daniël van Denderen, Bastien Mérigot
Scientific bottom-trawl surveys are ecological observation programs conducted along continental shelves and slopes of seas and oceans that sample marine communities associated with the seafloor. These surveys report taxa occurrence, abundance and/or weight in space and time, and contribute to fisheries management as well as population and biodiversity research. Bottom-trawl surveys are conducted all over the world and represent a unique opportunity to understand ocean biogeography, macroecology, and global change...
January 4, 2024: Scientific Data
https://read.qxmd.com/read/38170567/continuity-of-radiologists-between-diagnostic-breast-imaging-and-image-guided-breast-biopsy-impact-on-patient-reported-biopsy-morbidity-experiences
#22
JOURNAL ARTICLE
Carol McLaughlin, Sarah E H Moorman, Chen Yin, Prasad R Shankar, Matthew S Davenport, Colleen H Neal, Renee W Pinsky, Akshat C Pujara
OBJECTIVE: To determine whether continuity of care between diagnostic breast imaging and subsequent image-guided breast biopsy could reduce patient-reported biopsy-related morbidity. METHODS: This was a prospective, pragmatically randomized, 2-arm health utilities analysis of 200 women undergoing diagnostic breast imaging followed by US- or stereotactic-guided breast biopsy at a single quaternary care center from September 3, 2019, to April 10, 2023. Breast biopsy-naïve women with a BI-RADS 4 or 5 finding at diagnostic imaging were randomly scheduled for the typically first available biopsy appointment...
January 3, 2024: Journal of breast imaging
https://read.qxmd.com/read/38126845/application-of-cardiovascular-physiology-to-the-critically-ill-patient
#23
JOURNAL ARTICLE
Ronald A Bronicki, Sebastian Tume, Hernando Gomez, Cameron Dezfulian, Daniel J Penny, Michael R Pinsky, Daniel Burkhoff
OBJECTIVES: To use the ventricular pressure-volume relationship and time-varying elastance model to provide a foundation for understanding cardiovascular physiology and pathophysiology, interpreting advanced hemodynamic monitoring, and for illustrating the physiologic basis and hemodynamic effects of therapeutic interventions. We will build on this foundation by using a cardiovascular simulator to illustrate the application of these principles in the care of patients with severe sepsis, cardiogenic shock, and acute mechanical circulatory support...
December 21, 2023: Critical Care Medicine
https://read.qxmd.com/read/38062332/pathophysiological-implications-of-ventriculoarterial-coupling-in-septic-shock
#24
REVIEW
Michael R Pinsky, Fabio Guarracino
No abstract text is available yet for this article.
December 7, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38000395/measurements-of-groomed-jet-substructure-of-charm-jets-tagged-by-d-0-mesons-in-proton-proton-collisions-at-sqrt-s-13%C3%A2-%C3%A2-tev
#25
JOURNAL ARTICLE
S Acharya, D Adamová, A Adler, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, S Ahmad, S U Ahn, I Ahuja, A Akindinov, M Al-Turany, D Aleksandrov, B Alessandro, H M Alfanda, R Alfaro Molina, B Ali, Y Ali, A Alici, N Alizadehvandchali, A Alkin, J Alme, G Alocco, T Alt, I Altsybeev, M N Anaam, C Andrei, A Andronic, V Anguelov, F Antinori, P Antonioli, C Anuj, N Apadula, L Aphecetche, H Appelshäuser, C Arata, S Arcelli, M Aresti, R Arnaldi, I C Arsene, M Arslandok, A Augustinus, R Averbeck, M D Azmi, A Badalà, Y W Baek, X Bai, R Bailhache, Y Bailung, R Bala, A Balbino, A Baldisseri, B Balis, D Banerjee, Z Banoo, R Barbera, F Barile, L Barioglio, M Barlou, G G Barnaföldi, L S Barnby, V Barret, L Barreto, C Bartels, K Barth, E Bartsch, F Baruffaldi, N Bastid, S Basu, G Batigne, D Battistini, B Batyunya, D Bauri, J L Bazo Alba, I G Bearden, C Beattie, P Becht, D Behera, I Belikov, A D C Bell Hechavarria, F Bellini, R Bellwied, S Belokurova, V Belyaev, G Bencedi, S Beole, A Bercuci, Y Berdnikov, A Berdnikova, L Bergmann, M G Besoiu, L Betev, P P Bhaduri, A Bhasin, M A Bhat, B Bhattacharjee, L Bianchi, N Bianchi, J Bielčík, J Bielčíková, J Biernat, A P Bigot, A Bilandzic, G Biro, S Biswas, N Bize, J T Blair, D Blau, M B Blidaru, N Bluhme, C Blume, G Boca, F Bock, T Bodova, A Bogdanov, S Boi, J Bok, L Boldizsár, A Bolozdynya, M Bombara, P M Bond, G Bonomi, H Borel, A Borissov, H Bossi, E Botta, Y E M Bouziani, L Bratrud, P Braun-Munzinger, M Bregant, M Broz, G E Bruno, M D Buckland, D Budnikov, H Buesching, S Bufalino, O Bugnon, P Buhler, Z Buthelezi, J B Butt, S A Bysiak, M Cai, H Caines, A Caliva, E Calvo Villar, J M M Camacho, P Camerini, F D M Canedo, M Carabas, F Carnesecchi, R Caron, J Castillo Castellanos, F Catalano, C Ceballos Sanchez, I Chakaberia, P Chakraborty, S Chandra, S Chapeland, M Chartier, S Chattopadhyay, S Chattopadhyay, T G Chavez, T Cheng, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, E S Chizzali, J Cho, S Cho, P Chochula, P Christakoglou, C H Christensen, P Christiansen, T Chujo, M Ciacco, C Cicalo, L Cifarelli, F Cindolo, M R Ciupek, G Clai, F Colamaria, J S Colburn, D Colella, M Colocci, M Concas, G Conesa Balbastre, Z Conesa Del Valle, G Contin, J G Contreras, M L Coquet, T M Cormier, P Cortese, M R Cosentino, F Costa, S Costanza, J Crkovská, P Crochet, R Cruz-Torres, E Cuautle, P Cui, L Cunqueiro, A Dainese, M C Danisch, A Danu, P Das, P Das, S Das, A R Dash, S Dash, R M H David, A De Caro, G de Cataldo, J de Cuveland, A De Falco, D De Gruttola, N De Marco, C De Martin, S De Pasquale, S Deb, R J Debski, K R Deja, R Del Grande, L Dello Stritto, W Deng, P Dhankher, D Di Bari, A Di Mauro, R A Diaz, T Dietel, Y Ding, R Divià, D U Dixit, Ø Djuvsland, U Dmitrieva, A Dobrin, B Dönigus, A K Dubey, J M Dubinski, A Dubla, S Dudi, P Dupieux, M Durkac, N Dzalaiova, T M Eder, R J Ehlers, V N Eikeland, F Eisenhut, D Elia, B Erazmus, F Ercolessi, F Erhardt, M R Ersdal, B Espagnon, G Eulisse, D Evans, S Evdokimov, L Fabbietti, M Faggin, J Faivre, F Fan, W Fan, A Fantoni, M Fasel, P Fecchio, A Feliciello, G Feofilov, A Fernández Téllez, M B Ferrer, A Ferrero, C Ferrero, A Ferretti, V J G Feuillard, V Filova, D Finogeev, F M Fionda, F Flor, A N Flores, S Foertsch, I Fokin, S Fokin, E Fragiacomo, E Frajna, U Fuchs, N Funicello, C Furget, A Furs, T Fusayasu, J J Gaardhøje, M Gagliardi, A M Gago, C D Galvan, D R Gangadharan, P Ganoti, C Garabatos, J R A Garcia, E Garcia-Solis, K Garg, C Gargiulo, A Garibli, K Garner, A Gautam, M B Gay Ducati, M Germain, C Ghosh, S K Ghosh, M Giacalone, P Gianotti, P Giubellino, P Giubilato, A M C Glaenzer, P Glässel, E Glimos, D J Q Goh, V Gonzalez, L H González-Trueba, M Gorgon, S Gotovac, V Grabski, L K Graczykowski, E Grecka, A Grelli, C Grigoras, V Grigoriev, S Grigoryan, F Grosa, J F Grosse-Oetringhaus, R Grosso, D Grund, G G Guardiano, R Guernane, M Guilbaud, K Gulbrandsen, T Gundem, T Gunji, W Guo, A Gupta, R Gupta, S P Guzman, L Gyulai, M K Habib, C Hadjidakis, H Hamagaki, M Hamid, Y Han, R Hannigan, M R Haque, J W Harris, A Harton, H Hassan, D Hatzifotiadou, P Hauer, L B Havener, S T Heckel, E Hellbär, H Helstrup, M Hemmer, T Herman, G Herrera Corral, F Herrmann, S Herrmann, K F Hetland, B Heybeck, H Hillemanns, C Hills, B Hippolyte, B Hofman, B Hohlweger, J Honermann, G H Hong, A Horzyk, R Hosokawa, Y Hou, P Hristov, C Hughes, P Huhn, L M Huhta, C V Hulse, T J Humanic, H Hushnud, A Hutson, D Hutter, J P Iddon, R Ilkaev, H Ilyas, M Inaba, G M Innocenti, M Ippolitov, A Isakov, T Isidori, M S Islam, M Ivanov, M Ivanov, V Ivanov, V Izucheev, M Jablonski, B Jacak, N Jacazio, P M Jacobs, S Jadlovska, J Jadlovsky, S Jaelani, L Jaffe, C Jahnke, M J Jakubowska, M A Janik, T Janson, M Jercic, O Jevons, A A P Jimenez, F Jonas, P G Jones, J M Jowett, J Jung, M Jung, A Junique, A Jusko, M J Kabus, J Kaewjai, P Kalinak, A S Kalteyer, A Kalweit, V Kaplin, A Karasu Uysal, D Karatovic, O Karavichev, T Karavicheva, P Karczmarczyk, E Karpechev, V Kashyap, U Kebschull, R Keidel, D L D Keijdener, M Keil, B Ketzer, A M Khan, S Khan, A Khanzadeev, Y Kharlov, A Khatun, A Khuntia, B Kileng, B Kim, C Kim, D J Kim, E J Kim, J Kim, J S Kim, J Kim, J Kim, M Kim, S Kim, T Kim, K Kimura, S Kirsch, I Kisel, S Kiselev, A Kisiel, J P Kitowski, J L Klay, J Klein, S Klein, C Klein-Bösing, M Kleiner, T Klemenz, A Kluge, A G Knospe, C Kobdaj, T Kollegger, A Kondratyev, E Kondratyuk, J Konig, S A Konigstorfer, P J Konopka, G Kornakov, S D Koryciak, A Kotliarov, O Kovalenko, V Kovalenko, M Kowalski, I Králik, A Kravčáková, L Kreis, M Krivda, F Krizek, K Krizkova Gajdosova, M Kroesen, M Krüger, D M Krupova, E Kryshen, V Kučera, C Kuhn, P G Kuijer, T Kumaoka, D Kumar, L Kumar, N Kumar, S Kumar, S Kundu, P Kurashvili, A Kurepin, A B Kurepin, S Kushpil, J Kvapil, M J Kweon, J Y Kwon, Y Kwon, S L La Pointe, P La Rocca, Y S Lai, A Lakrathok, M Lamanna, R Langoy, P Larionov, E Laudi, L Lautner, R Lavicka, T Lazareva, R Lea, G Legras, J Lehrbach, R C Lemmon, I León Monzón, M M Lesch, E D Lesser, M Lettrich, P Lévai, X Li, X L Li, J Lien, R Lietava, B Lim, S H Lim, V Lindenstruth, A Lindner, C Lippmann, A Liu, D H Liu, J Liu, I M Lofnes, C Loizides, P Loncar, J A Lopez, X Lopez, E López Torres, P Lu, J R Luhder, M Lunardon, G Luparello, Y G Ma, A Maevskaya, M Mager, T Mahmoud, A Maire, M Malaev, G Malfattore, N M Malik, Q W Malik, S K Malik, L Malinina, D Mal'Kevich, D Mallick, N Mallick, G Mandaglio, V Manko, F Manso, V Manzari, Y Mao, G V Margagliotti, A Margotti, A Marín, C Markert, P Martinengo, J L Martinez, M I Martínez, G Martínez García, S Masciocchi, M Masera, A Masoni, L Massacrier, A Mastroserio, A M Mathis, O Matonoha, P F T Matuoka, A Matyja, C Mayer, A L Mazuecos, F Mazzaschi, M Mazzilli, J E Mdhluli, A F Mechler, Y Melikyan, A Menchaca-Rocha, E Meninno, A S Menon, M Meres, S Mhlanga, Y Miake, L Micheletti, L C Migliorin, D L Mihaylov, K Mikhaylov, A N Mishra, D Miśkowiec, A Modak, A P Mohanty, B Mohanty, M Mohisin Khan, M A Molander, Z Moravcova, C Mordasini, D A Moreira De Godoy, I Morozov, A Morsch, T Mrnjavac, V Muccifora, S Muhuri, J D Mulligan, A Mulliri, M G Munhoz, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, J W Myrcha, B Naik, R Nair, A I Nambrath, B K Nandi, R Nania, E Nappi, A F Nassirpour, A Nath, C Nattrass, A Neagu, A Negru, L Nellen, S V Nesbo, G Neskovic, D Nesterov, B S Nielsen, E G Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, S Noh, P Nomokonov, J Norman, N Novitzky, P Nowakowski, A Nyanin, J Nystrand, M Ogino, A Ohlson, V A Okorokov, J Oleniacz, A C Oliveira Da Silva, M H Oliver, A Onnerstad, C Oppedisano, A Ortiz Velasquez, A Oskarsson, J Otwinowski, M Oya, K Oyama, Y Pachmayer, S Padhan, D Pagano, G Paić, A Palasciano, S Panebianco, H Park, J Park, J E Parkkila, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, M Pennisi, L G Pereira, H Pereira Da Costa, D Peresunko, G M Perez, S Perrin, Y Pestov, V Petráček, V Petrov, M Petrovici, R P Pezzi, S Piano, M Pikna, P Pillot, O Pinazza, L Pinsky, C Pinto, S Pisano, M Płoskoń, M Planinic, F Pliquett, M G Poghosyan, S Politano, N Poljak, A Pop, S Porteboeuf-Houssais, J Porter, V Pozdniakov, S K Prasad, S Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, S Pucillo, Z Pugelova, S Qiu, L Quaglia, R E Quishpe, S Ragoni, A Rakotozafindrabe, L Ramello, F Rami, S A R Ramirez, T A Rancien, R Raniwala, S Raniwala, M Rasa, S S Räsänen, R Rath, I Ravasenga, K F Read, C Reckziegel, A R Redelbach, K Redlich, A Rehman, F Reidt, H A Reme-Ness, Z Rescakova, K Reygers, A Riabov, V Riabov, R Ricci, T Richert, M Richter, A A Riedel, W Riegler, F Riggi, C Ristea, M Rodríguez Cahuantzi, K Røed, R Rogalev, E Rogochaya, T S Rogoschinski, D Rohr, D Röhrich, P F Rojas, S Rojas Torres, P S Rokita, G Romanenko, F Ronchetti, A Rosano, E D Rosas, A Rossi, A Roy, P Roy, S Roy, N Rubini, O V Rueda, D Ruggiano, R Rui, B Rumyantsev, P G Russek, R Russo, A Rustamov, E Ryabinkin, Y Ryabov, A Rybicki, H Rytkonen, W Rzesa, O A M Saarimaki, R Sadek, S Sadhu, S Sadovsky, J Saetre, K Šafařík, S K Saha, S Saha, B Sahoo, R Sahoo, S Sahoo, D Sahu, P K Sahu, J Saini, K Sajdakova, S Sakai, M P Salvan, S Sambyal, T B Saramela, D Sarkar, N Sarkar, P Sarma, V Sarritzu, V M Sarti, M H P Sas, J Schambach, H S Scheid, C Schiaua, R Schicker, A Schmah, C Schmidt, H R Schmidt, M O Schmidt, M Schmidt, N V Schmidt, A R Schmier, R Schotter, J Schukraft, K Schwarz, K Schweda, G Scioli, E Scomparin, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, S Senyukov, J J Seo, D Serebryakov, L Šerkšnytė, A Sevcenco, T J Shaba, A Shabetai, R Shahoyan, A Shangaraev, A Sharma, D Sharma, H Sharma, M Sharma, N Sharma, S Sharma, S Sharma, U Sharma, A Shatat, O Sheibani, K Shigaki, M Shimomura, S Shirinkin, Q Shou, Y Sibiriak, S Siddhanta, T Siemiarczuk, T F Silva, D Silvermyr, T Simantathammakul, R Simeonov, B Singh, B Singh, R Singh, R Singh, R Singh, S Singh, V K Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, G Skorodumovs, M Slupecki, N Smirnov, R J M Snellings, E H Solheim, J Song, A Songmoolnak, F Soramel, S Sorensen, R Spijkers, I Sputowska, J Staa, J Stachel, I Stan, P J Steffanic, S F Stiefelmaier, D Stocco, I Storehaug, M M Storetvedt, P Stratmann, S Strazzi, C P Stylianidis, A A P Suaide, C Suire, M Sukhanov, M Suljic, V Sumberia, S Sumowidagdo, S Swain, I Szarka, U Tabassam, S F Taghavi, G Taillepied, J Takahashi, G J Tambave, S Tang, Z Tang, J D Tapia Takaki, N Tapus, L A Tarasovicova, M G Tarzila, G F Tassielli, A Tauro, A Telesca, L Terlizzi, C Terrevoli, G Tersimonov, S Thakur, D Thomas, A Tikhonov, A R Timmins, M Tkacik, T Tkacik, A Toia, R Tokumoto, N Topilskaya, M Toppi, F Torales-Acosta, T Tork, A G Torres Ramos, A Trifiró, A S Triolo, S Tripathy, T Tripathy, S Trogolo, V Trubnikov, W H Trzaska, T P Trzcinski, R Turrisi, T S Tveter, K Ullaland, B Ulukutlu, A Uras, M Urioni, G L Usai, M Vala, N Valle, S Vallero, L V R van Doremalen, M van Leeuwen, C A van Veen, R J G van Weelden, P Vande Vyvre, D Varga, Z Varga, M Varga-Kofarago, M Vasileiou, A Vasiliev, O Vázquez Doce, V Vechernin, E Vercellin, S Vergara Limón, L Vermunt, R Vértesi, M Verweij, L Vickovic, Z Vilakazi, O Villalobos Baillie, G Vino, A Vinogradov, T Virgili, V Vislavicius, A Vodopyanov, B Volkel, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, N Vozniuk, J Vrláková, B Wagner, C Wang, D Wang, A Wegrzynek, F T Weiglhofer, S C Wenzel, J P Wessels, S L Weyhmiller, J Wiechula, J Wikne, G Wilk, J Wilkinson, G A Willems, B Windelband, M Winn, J R Wright, W Wu, Y Wu, R Xu, A Yadav, A K Yadav, S Yalcin, Y Yamaguchi, K Yamakawa, S Yang, S Yano, Z Yin, I-K Yoo, J H Yoon, S Yuan, A Yuncu, V Zaccolo, C Zampolli, H J C Zanoli, F Zanone, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, M Zhalov, B Zhang, S Zhang, X Zhang, Y Zhang, Z Zhang, M Zhao, V Zherebchevskii, Y Zhi, N Zhigareva, D Zhou, Y Zhou, J Zhu, Y Zhu, G Zinovjev, N Zurlo
Understanding the role of parton mass and Casimir color factors in the quantum chromodynamics parton shower represents an important step in characterizing the emission properties of heavy quarks. Recent experimental advances in jet substructure techniques have provided the opportunity to isolate and characterize gluon emissions from heavy quarks. In this Letter, the first direct experimental constraint on the charm-quark splitting function is presented, obtained via the measurement of the groomed shared momentum fraction of the first splitting in charm jets, tagged by a reconstructed D^{0} meson...
November 10, 2023: Physical Review Letters
https://read.qxmd.com/read/37990024/ba-5-bivalent-booster-vaccination-enhances-neutralization-of-xbb-1-5-xbb-1-16-and-xbb-1-9-variants-in-patients-with-lung-cancer
#26
JOURNAL ARTICLE
Rajesh M Valanparambil, Lilin Lai, Margaret A Johns, Meredith Davis-Gardner, Susanne L Linderman, Tarrant Oliver McPherson, Andres Chang, Akil Akhtar, Estefany L Bocangel Gamarra, Hayley Matia, Ashley A McCook-Veal, Jeffrey Switchenko, Tahseen H Nasti, Felicia Green, Manpreet Saini, Andreas Wieland, Benjamin A Pinsky, Daniel Solis, Madhav V Dhodapkar, Jennifer Carlisle, Suresh Ramalingam, Rafi Ahmed, Mehul S Suthar
This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulating Omicron variants after bivalent booster vaccination and had Ab titers comparable to healthy participants. Interestingly, though the durability of the nAb response persisted in most of the healthy participants, patients with NSCLC had significantly reduced nAb titers after 4-6 months of vaccination. Our data highlight the importance of COVID-19 bivalent booster vaccination as the standard of care for patients with NSCLC given the evolution of new variants of concern...
November 21, 2023: NPJ Vaccines
https://read.qxmd.com/read/37984678/incidentally-detected-lung-cancer-in-persons-too-young-or-too-old-for-lung-cancer-screening-in-a-mississippi-delta-cohort
#27
JOURNAL ARTICLE
Wei Liao, Carrie Fehnel, Jordan Goss, Catherine J Shepherd, Talat Qureshi, Anberitha T Matthews, Meredith A Ray, Nicholas R Faris, Paul F Pinsky, Matthew P Smeltzer, Raymond U Osarogiagbon
INTRODUCTION: Lung cancer risk in screening age-ineligible persons with incidentally-detected lung nodules is poorly characterized. We evaluated lung cancer risk in two age-ineligible Lung Nodule Program (LNP) cohorts. METHODS: Prospective observational study comparing 2-year cumulative lung cancer diagnosis risk, lung cancer characteristics and overall survival (OS) between low-dose CT (LDCT) screening participants aged 50-80 years and LNP participants aged 35 - <50 years (young) and >80 years (elderly)...
November 18, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37965143/tmem106b-reduction-does-not-rescue-grn-deficiency-in-ipsc-derived-human-microglia-and-mouse-models
#28
JOURNAL ARTICLE
Sara L Dominguez, Benjamin I Laufer, Arundhati Sengupta Ghosh, Qingling Li, Gaia Ruggeri, Maheswara Reddy Emani, Lilian Phu, Brad A Friedman, Wendy Sandoval, Christopher M Rose, Hai Ngu, Oded Foreman, Mike Reichelt, Yves Juste, Guita Lalehzadeh, Dennis Hansen, Helle Nymark, Denia Mellal, Helene Gylling, Łukasz J Kiełpiński, Ben Chih, Baris Bingol, Casper C Hoogenraad, William J Meilandt, Amy Easton
Heterozygous mutations in the granulin ( GRN ) gene are a leading cause of frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Polymorphisms in TMEM106B have been associated with disease risk in GRN mutation carriers and protective TMEM106B variants associated with reduced levels of TMEM106B, suggesting that lowering TMEM106B might be therapeutic in the context of FTLD. Here, we tested the impact of full deletion and partial reduction of TMEM106B in mouse and iPSC-derived human cell models of GRN deficiency...
November 17, 2023: IScience
https://read.qxmd.com/read/37945089/particle-showers-detected-on-iss-in-timepix-pixel-detectors
#29
JOURNAL ARTICLE
Martin Kroupa, Thomas Campbell-Ricketts, Stuart P George, Amir A Bahadori, Lawrence S Pinsky
We detect regular particle showers in several compact pixel detectors, distributed over the International Space Station. These showers are caused by high energy galactic cosmic rays, with energies often in the 10 s of TeV or higher. We survey the frequency of these events, their dependence on location on ISS, and their independence of the location of ISS, on its orbit. The Timepix detectors used allow individual particle tracks to be resolved, providing a possibility to perform physical analysis of shower events, which we demonstrate...
November 2023: Life Sciences in Space Research
https://read.qxmd.com/read/37943111/the-importance-of-oxygen-for-explaining-rapid-shifts-in-a-marine-fish
#30
JOURNAL ARTICLE
Rathnayaka Mudiyanselage Wajra Jeewantha Bandara, Enrique Curchitser, Malin L Pinsky
Large-scale shifts in marine species biogeography have been a notable impact of climate change. An effective explanation of what drives these species shifts, as well as accurate predictions of where they might move, is crucial to effectively managing these natural resources and conserving biodiversity. While temperature has been implicated as a major driver of these shifts, physiological processes suggest that oxygen, prey, and other factors should also play important roles. We expanded upon previous temperature-based distribution models by testing whether oxygen, food web productivity, salinity, and scope for metabolic activity (the Metabolic Index) better explained the changing biogeography of Black Sea Bass (Centropristis striata) in the Northeast US...
November 9, 2023: Global Change Biology
https://read.qxmd.com/read/37872316/global-and-cell-type-specific-immunological-hallmarks-of-severe-dengue-progression-identified-via-a-systems-immunology-approach
#31
JOURNAL ARTICLE
Luca Ghita, Zhiyuan Yao, Yike Xie, Veronica Duran, Halise Busra Cagirici, Jerome Samir, Ilham Osman, David Esteban Rebellón-Sánchez, Olga Lucia Agudelo-Rojas, Ana Maria Sanz, Malaya Kumar Sahoo, Makeda L Robinson, Rosa Margarita Gelvez-Ramirez, Nathalia Bueno, Fabio Luciani, Benjamin A Pinsky, Jose G Montoya, Maria Isabel Estupiñan-Cardenas, Luis Angel Villar-Centeno, Elsa Marina Rojas-Garrido, Fernando Rosso, Stephen R Quake, Fabio Zanini, Shirit Einav
Severe dengue (SD) is a major cause of morbidity and mortality. To define dengue virus (DENV) target cells and immunological hallmarks of SD progression in children's blood, we integrated two single-cell approaches capturing cellular and viral elements: virus-inclusive single-cell RNA sequencing (viscRNA-Seq 2) and targeted proteomics with secretome analysis and functional assays. Beyond myeloid cells, in natural infection, B cells harbor replicating DENV capable of infecting permissive cells. Alterations in cell type abundance, gene and protein expression and secretion as well as cell-cell communications point towards increased immune cell migration and inflammation in SD progressors...
October 23, 2023: Nature Immunology
https://read.qxmd.com/read/37862406/assessment-of-dlpno-mp2-approximations-in-double-hybrid-dft
#32
JOURNAL ARTICLE
Hagen Neugebauer, Peter Pinski, Stefan Grimme, Frank Neese, Markus Bursch
The unfavorable scaling ( N 5 ) of the conventional second-order Møller-Plesset theory (MP2) typically prevents the application of double-hybrid (DH) density functionals to large systems with more than 100 atoms. A prominent approach to reduce the computational demand of electron correlation methods is the domain-based local pair natural orbital (DLPNO) approximation that is successfully used in the framework of DLPNO-CCSD(T). Its extension to MP2 [Pinski P.; Riplinger, C.; Valeev, E. F.; Neese, F. J. Chem...
October 20, 2023: Journal of Chemical Theory and Computation
https://read.qxmd.com/read/37807187/a-56-examining-the-impact-of-cognition-and-training-on-successful-usage-of-an-assistive-smartphone-application-for-older-adults-experiencing-cognitive-decline
#33
JOURNAL ARTICLE
Moira E Mckniff, Katherine Hackett, Emma Pinsky, Sarah Lehman, Chiu Tan, Tania Giovannetti
OBJECTIVE: The SmartPrompt is an assistive smartphone application designed to prompt older adults to remember to do daily tasks and then log task completion in a photo log for later review. Here we examine whether and how cognitive status and performance during training with the SmartPrompt influenced usage of the app over a two-week testing period at Temple University. METHOD: Nine community-dwelling older adults (M age = 77 ± 5...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37801004/human-immunodeficiency-virus-1-5-leader-mutations-in-plasma-viruses-before-and-after-the-development-of-reverse-transcriptase-inhibitor-resistance-mutations
#34
JOURNAL ARTICLE
Janin Nouhin, Philip Lei Tzou, Soo-Yon Rhee, Malaya K Sahoo, Benjamin A Pinsky, Miri Krupkin, Joseph D Puglisi, Elisabetta V Puglisi, Robert W Shafer
Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT) initiation depends on interaction between viral 5'-leader RNA, RT and host tRNA3Lys . Therefore, we sought to identify co-evolutionary changes between the 5'-leader and RT in viruses developing RT-inhibitor resistance mutations. We sequenced 5'-leader positions 37-356 of paired plasma virus samples from 29 individuals developing the nucleoside RT inhibitor (NRTI)-resistance mutation M184V, 19 developing a non-nucleoside RT inhibitor (NNRTI)-resistance mutation and 32 untreated controls...
October 2023: Journal of General Virology
https://read.qxmd.com/read/37791504/predictive-performance-of-cell-free-nucleic-acid-based-multi-cancer-early-detection-tests-a-systematic-review
#35
JOURNAL ARTICLE
Elyse LeeVan, Paul Pinsky
BACKGROUND: Cancer-screening tests that can detect multiple cancer types, or multi-cancer early detection (MCED) tests, have emerged recently as a potential new tool in decreasing cancer morbidity and mortality. Most MCED assays are based on detecting cell-free tumor DNA (CF-DNA) in the blood. MCEDs offer the potential for screening for cancer organ sites with high mortality, both with and without recommended screening. However, their clinical utility has not been established. Before clinical utility can be established, the clinical validity of MCEDs, i...
October 4, 2023: Clinical Chemistry
https://read.qxmd.com/read/37788527/assessment-of-an-automated-cytomegalovirus-nucleic-acid-amplification-test-using-clinical-plasma-bronchoalveolar-lavage-and-tissue-specimens
#36
JOURNAL ARTICLE
ChunHong Huang, Daniel Solis, Malaya K Sahoo, Benjamin A Pinsky
BACKGROUND: Cytomegalovirus (CMV) causes significant morbidity and mortality in immunocompromised patients, particularly transplant recipients. Quantitation of CMV DNA in peripheral blood is used to monitor prophylactic and pre-emptive approaches to prevent CMV disease, whereas CMV DNA testing of non-plasma specimens may aid in the diagnosis of end-organ disease. METHODS: The analytical performance of the FDA-approved Aptima CMV Quant Assay was evaluated using reference CMV (SeraCare) diluted in defibrinated human plasma, as well as negative bronchoalveolar lavage fluid and tissue...
September 9, 2023: Journal of Clinical Virology
https://read.qxmd.com/read/37784557/local-cost-effectiveness-of-nasopharyngeal-carcinoma-screening-strategies-in-southern-china-secondary-analysis-of-the-pro-npc-001-cluster-randomized-trial
#37
JOURNAL ARTICLE
J A Miller, Z Liu, B Pinsky, Q T Le, T Li, S Cao, A Hildesheim
PURPOSE/OBJECTIVE(S): Population-based screening for endemic nasopharyngeal carcinoma (NPC) detects most cases at an early stage. In a cluster-randomized trial conducted in Guangdong, a combination of Epstein-Barr Virus (EBV) anti-VCA/EBNA1 IgA serology and endoscopy reduced NPC mortality. We conducted a secondary analysis of this trial in conjunction with local incidence and cost data, hypothesizing that screening would be cost-effective in this region. MATERIALS/METHODS: We estimated population-level NPC mortality reduction, resource utilization, and cost-effectiveness of 12 unique screening strategies in six populations in Guangdong/Guangxi using a previously-validated time-inhomogeneous decision-analytic cohort model...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37769311/low-dose-elagolix-for-the-treatment-of-heavy-menstrual-bleeding-in-patients-with-uterine-leiomyomas-a-randomized-controlled-trial
#38
RANDOMIZED CONTROLLED TRIAL
Eric Brown, Robin Kroll, Hong Li, Juki Ng, Brett Pinsky, Jose W Rodriguez, James Thomas, Michael C Snabes
OBJECTIVE: To evaluate the safety and efficacy of elagolix 150 mg once-daily monotherapy in patients with heavy menstrual bleeding associated with uterine leiomyomas. METHODS: A phase 4, randomized, double-blind, placebo-controlled, 6-month treatment study was conducted in premenopausal patients aged 18-51 years with heavy menstrual bleeding (defined as menstrual blood loss greater than 80 mL during one menstrual cycle) associated with uterine leiomyomas. Patients were randomized 2:1 to receive elagolix 150 mg once daily or placebo...
November 1, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/37746805/low-infectivity-among-asymptomatic-patients-with-a-positive-severe-acute-respiratory-coronavirus-virus-2-sars-cov-2-admission-test-at-a-tertiary-care-center-2020-2022
#39
JOURNAL ARTICLE
Ralph Tayyar, Melanie A Kiener, Jane W Liang, Gustavo Contreras, Guillermo Rodriguez-Nava, Alex N Zimmet, Caitlin A Contag, Krithika Srinivasan, Karen McIntyre, Aruna Subramanian, John Shepard, Lucy S Tompkins, Benjamin A Pinsky, Jorge L Salinas
We used a strand-specific RT-qPCR to evaluate viral replication as a surrogate for infectiousness among 242 asymptomatic inpatients with a positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) admission test. Only 21 patients (9%) had detectable SARS-CoV-2 minus-strand RNA. Because most patients were found to be noninfectious, our findings support the suspension of asymptomatic admission testing.
September 25, 2023: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/37746024/efficient-agrobacterium-mediated-transformation-and-genome-editing-of-fagopyrum-tataricum
#40
JOURNAL ARTICLE
Artur Pinski, Alexander Betekhtin
Fagopyrum tataricum (L.) Gaertn. is an exceptional crop known for its remarkable health benefits, high levels of beneficial polyphenols and gluten-free properties, making it highly sought-after as a functional food. Its self-fertilisation capability and adaptability to challenging environments further contribute to its potential as a sustainable agricultural option. To harness its unique traits, genetic transformation in F. tataricum is crucial. In this study, we optimised the Agrobacterium-mediated transformation protocol for F...
2023: Frontiers in Plant Science
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