keyword
https://read.qxmd.com/read/38613240/bringing-traits-back-into-the-equation-a-roadmap-to-understand-species-redistribution
#1
JOURNAL ARTICLE
Lise Comte, Romain Bertrand, Sarah Diamond, Lesley T Lancaster, Malin L Pinsky, Brett R Scheffers, J Alex Baecher, R M W J Bandara, I-Ching Chen, Jake A Lawlor, Nikki A Moore, Brunno F Oliveira, Jerome Murienne, Jonathan Rolland, Madeleine A Rubenstein, Jennifer Sunday, Laura M Thompson, Fabricio Villalobos, Sarah R Weiskopf, Jonathan Lenoir
Ecological and evolutionary theories have proposed that species traits should be important in mediating species responses to contemporary climate change; yet, empirical evidence has so far provided mixed evidence for the role of behavioral, life history, or ecological characteristics in facilitating or hindering species range shifts. As such, the utility of trait-based approaches to predict species redistribution under climate change has been called into question. We develop the perspective, supported by evidence, that trait variation, if used carefully can have high potential utility, but that past analyses have in many cases failed to identify an explanatory value for traits by not fully embracing the complexity of species range shifts...
April 2024: Global Change Biology
https://read.qxmd.com/read/38603624/increasing-power-in-screening-trials-by-testing-control-arm-specimens-application-to-multicancer-detection-screening
#2
JOURNAL ARTICLE
Hormuzd A Katki, Philip C Prorok, Philip E Castle, Lori M Minasian, Paul F Pinsky
BACKGROUND: Cancer screening trials have required large sample-sizes and long time-horizons to demonstrate cancer mortality reductions, the primary goal of cancer screening. We examine assumptions and potential power gains from exploiting information from testing control-arm specimens, which we call the "Intended Effect" (IE) analysis that we explain in detail herein. The IE analysis is particularly suited to tests that can be conducted on stored specimens in the control-arm, such as stored blood for multicancer detection (MCD) tests...
April 11, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38589940/use-of-artificial-intelligence-in-critical-care-opportunities-and-obstacles
#3
REVIEW
Michael R Pinsky, Armando Bedoya, Azra Bihorac, Leo Celi, Matthew Churpek, Nicoleta J Economou-Zavlanos, Paul Elbers, Suchi Saria, Vincent Liu, Patrick G Lyons, Benjamin Shickel, Patrick Toral, David Tscholl, Gilles Clermont
BACKGROUND: Perhaps nowhere else in the healthcare system than in the intensive care unit environment are the challenges to create useful models with direct time-critical clinical applications more relevant and the obstacles to achieving those goals more massive. Machine learning-based artificial intelligence (AI) techniques to define states and predict future events are commonplace activities of modern life. However, their penetration into acute care medicine has been slow, stuttering and uneven...
April 8, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38559667/parsimonious-waveform-derived-features-consisting-of-pulse-arrival-time-and-heart-rate-variability-predicts-the-onset-of-septic-shock
#4
JOURNAL ARTICLE
Moamen M Soliman, Curtis Marshall, Jacob P Kimball, Tilendra Choudhary, Gilles Clermont, Michael R Pinsky, Timothy G Buchman, Craig M Coopersmith, Omer T Inan, Rishikesan Kamaleswaran
Sepsis is a major public health emergency and one of the leading causes of morbidity and mortality in critically ill patients. For each hour treatment is delayed, shock-related mortality increases, so early diagnosis and intervention is of utmost importance. However, earlier recognition of shock requires active monitoring, which may be delayed due to subclinical manifestations of the disease at the early phase of onset. Machine learning systems can increase timely detection of shock onset by exploiting complex interactions among continuous physiological waveforms...
June 2024: Biomedical Signal Processing and Control
https://read.qxmd.com/read/38545607/early-physiologic-numerical-and-waveform-characteristics-of-simulated-hemorrhagic-events-with-healthy-volunteers-donating-blood
#5
JOURNAL ARTICLE
Joo Heung Yoon, Jueun Kim, Theodore Lagattuta, Michael R Pinsky, Marilyn Hravnak, Gilles Clermont
OBJECTIVES: Early signs of bleeding are often masked by the physiologic compensatory responses delaying its identification. We sought to describe early physiologic signatures of bleeding during the blood donation process. SETTING: Waveform-level vital sign data including electrocardiography, photoplethysmography (PPG), continuous noninvasive arterial pressure, and respiratory waveforms were collected before, during, and after bleeding. SUBJECTS: Fifty-five healthy volunteers visited blood donation center to donate whole blood...
April 2024: Critical care explorations
https://read.qxmd.com/read/38517462/cancer-screening-with-multicancer-detection-tests-a-translational-science-review
#6
REVIEW
Wendy S Rubinstein, Christos Patriotis, Anthony Dickherber, Paul K J Han, Hormuzd A Katki, Elyse LeeVan, Paul F Pinsky, Philip C Prorok, Amanda L Skarlupka, Sarah M Temkin, Philip E Castle, Lori M Minasian
Multicancer detection (MCD) tests use a single, easily obtainable biospecimen, such as blood, to screen for more than one cancer concurrently. MCD tests can potentially be used to improve early cancer detection, including cancers that currently lack effective screening methods. However, these tests have unknown and unquantified benefits and harms. MCD tests differ from conventional cancer screening tests in that the organ responsible for a positive test is unknown, and a broad diagnostic workup may be necessary to confirm the location and type of underlying cancer...
March 22, 2024: CA: a Cancer Journal for Clinicians
https://read.qxmd.com/read/38511328/monocyte-mediated-thrombosis-linked-to-circulating-tissue-factor-and-immune-paralysis-in-covid-19
#7
JOURNAL ARTICLE
Sascha N Goonewardena, Qinzhong Chen, Ashley M Tate, Olga G Grushko, Dilna Damodaran, Pennelope Blakely, Salim S Hayek, David J Pinsky, Robert S Rosenson
BACKGROUND: SARS-CoV-2 infections cause COVID-19 and are associated with inflammation, coagulopathy, and high incidence of thrombosis. Myeloid cells help coordinate the initial immune response in COVID-19. Although we appreciate that myeloid cells lie at the nexus of inflammation and thrombosis, the mechanisms that unite the two in COVID-19 remain largely unknown. METHODS: In this study, we used systems biology approaches including proteomics, transcriptomics, and mass cytometry to define the circulating proteome and circulating immune cell phenotypes in subjects with COVID-19...
March 21, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38497664/isolation-of-a-recombinant-simian-adenovirus-encoding-the-human-adenovirus-g52-hexon-suggests-a-simian-origin-for-human-adenovirus-g52
#8
JOURNAL ARTICLE
Amanda N Pinski, Tianyu Gan, Shih-Ching Lin, Lindsay Droit, Michael Diamond, Dan H Barouch, David Wang
Human adenoviruses (HAdVs) are causative agents of morbidity and mortality throughout the world. These double-stranded DNA viruses are phylogenetically classified into seven different species (A-G). HAdV-G52, originally isolated in 2008 from a patient presenting with gastroenteritis, is the sole human-derived member of species G. Phylogenetic analysis previously suggested that HAdV-G52 may have a simian origin, indicating a potential zoonotic spillover into humans. However, evidence of HAdV-G52 in either human or simian populations has not been reported since...
March 18, 2024: Journal of Virology
https://read.qxmd.com/read/38490774/severity-driven-trends-in-mortality-in-a-large-regionalized-critical-care-transport-service
#9
JOURNAL ARTICLE
David D Salcido, Chase W Zikmund, Leonard S Weiss, Andrew Schoenling, Christian Martin-Gill, Francis X Guyette, Michael R Pinsky
OBJECTIVE: The epidemiology accompanying helicopter emergency medical services (HEMS) transport has evolved as agencies have matured and become integrated into regionalized health systems, as evidenced primarily by nationwide systems in Europe. System-level congruence between Europe and the United States, where HEMS is geographically fragmentary, is unclear. In this study, we provide a temporal, epidemiologic characterization of the largest standardized private, nonprofit HEMS system in the United States, STAT MedEvac...
2024: Air Medical Journal
https://read.qxmd.com/read/38483559/consistency-of-data-reporting-in-fluid-responsiveness-studies-in-the-critically-ill-setting-the-codefire-consensus-from-the-cardiovascular-dynamic-section-of-the-european-society-of-intensive-care-medicine
#10
JOURNAL ARTICLE
Antonio Messina, Michelle S Chew, Daniele Poole, Lorenzo Calabrò, Daniel De Backer, Katia Donadello, Glenn Hernandez, Olfa Hamzaoui, Mathieu Jozwiak, Christopher Lai, Manu L N G Malbrain, Jihad Mallat, Sheyla Nainan Myatra, Laurent Muller, Gustavo Ospina-Tascon, Michael R Pinsky, Sebastian Preau, Bernd Saugel, Jean-Louis Teboul, Maurizio Cecconi, Xavier Monnet
PURPOSE: To provide consensus recommendations regarding hemodynamic data reporting in studies investigating fluid responsiveness and fluid challenge (FC) use in the intensive care unit (ICU). METHODS: The Executive Committee of the European Society of Intensive Care Medicine (ESICM) commissioned and supervised the project. A panel of 18 international experts and a methodologist identified main domains and items from a systematic literature, plus 2 ancillary domains...
March 14, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38466093/determination-of-the-cycle-threshold-value-of-the-xpert-xpress-sars-cov-2-flu-rsv-test-that-corresponds-to-the-presence-of-infectious-sars-cov-2-in-anterior-nasal-swabs
#11
JOURNAL ARTICLE
Ryan F Relich, Kayla Van Benten, Guang-Sheng Lei, Christopher M Robinson, Mariel Carozza, Malaya K Sahoo, ChunHong Huang, Daniel Solis, Mamdouh Sibai, Christopher A Myers, Cynthia Sikorski, Caroline Balagot, David Yang, Benjamin A Pinsky, Michael J Loeffelholz
Despite having high analytical sensitivities and specificities, qualitative SARS-CoV-2 nucleic acid amplification tests (NAATs) cannot distinguish infectious from non-infectious virus in clinical samples. In this study, we determined the highest cycle threshold (Ct) value of the SARS-CoV-2 targets in the Xpert Xpress SARS-CoV-2/Flu/RSV (Xpert 4plex) test that corresponded to the presence of detectable infectious SARS-CoV-2 in anterior nasal swab samples. A total of 111 individuals with nasopharyngeal swab specimens that were initially tested by the Xpert Xpress SARS-CoV-2 test were enrolled...
March 11, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38421651/effectiveness-of-colonoscopy-screening-vs-sigmoidoscopy-screening-in-colorectal-cancer
#12
RANDOMIZED CONTROLLED TRIAL
Frederik E Juul, Amanda J Cross, Robert E Schoen, Carlo Senore, Paul F Pinsky, Eric A Miller, Nereo Segnan, Kate Wooldrage, Paulina Wieszczy-Szczepanik, Paola Armaroli, Kjetil K Garborg, Hans-Olov Adami, Geir Hoff, Mette Kalager, Michael Bretthauer, Øyvind Holme, Magnus Løberg
IMPORTANCE: Randomized clinical screening trials have shown that sigmoidoscopy screening reduces colorectal cancer (CRC) incidence and mortality. Colonoscopy has largely replaced sigmoidoscopy for CRC screening, but long-term results from randomized trials on colonoscopy screening are still lacking. OBJECTIVE: To estimate the additional screening benefit of colonoscopy compared with sigmoidoscopy. DESIGN, SETTING, AND PARTICIPANTS: This comparative effectiveness simulation study pooled data on 358 204 men and women randomly assigned to sigmoidoscopy screening or usual care in 4 randomized sigmoidoscopy screening trials conducted in Norway, Italy, the US, and UK with inclusion periods in the years 1993 to 2001...
February 5, 2024: JAMA Network Open
https://read.qxmd.com/read/38399957/characterization-of-dengue-virus-4-cases-in-paraguay-2019-2020
#13
JOURNAL ARTICLE
Alejandra Rojas, John Shen, Fátima Cardozo, Cynthia Bernal, Oliver Caballero, Sara Ping, Autum Key, Ali Haider, Yvalena de Guillén, Patricia Langjahr, Maria Eugenia Acosta, Laura Aria, Laura Mendoza, Malvina Páez, Marta Von-Horoch, Patricia Luraschi, Sandra Cabral, María Cecilia Sánchez, Aurelia Torres, Benjamin A Pinsky, Anne Piantadosi, Jesse J Waggoner
In 2019-2020, dengue virus (DENV) type 4 emerged to cause the largest DENV outbreak in Paraguay's history. This study sought to characterize dengue relative to other acute illness cases and use phylogenetic analysis to understand the outbreak's origin. Individuals with an acute illness (≤7 days) were enrolled and tested for DENV nonstructural protein 1 (NS1) and viral RNA by real-time RT-PCR. Near-complete genome sequences were obtained from 62 DENV-4 positive samples. From January 2019 to March 2020, 799 participants were enrolled: 253 dengue (14 severe dengue, 5...
January 25, 2024: Viruses
https://read.qxmd.com/read/38370837/xbb-1-5-monovalent-booster-improves-antibody-binding-and-neutralization-against-emerging-sars-cov-2-omicron-variants
#14
Shilpi Jain, Sanjeev Kumar, Lilin Lai, Susanne Linderman, Ansa A Malik, Madison L Ellis, Sucheta Godbole, Daniel Solis, Malaya K Sahoo, Kareem Bechnak, Isabel Paredes, Ralph Tanios, Bahaa Kazzi, Serena M Dib, Matthew B Litvack, Sonia T Wimalasena, Caroline Ciric, Christina Rostad, Richard West, I-Ting Teng, Danyi Wang, Sri Edupuganti, Peter D Kwong, Nadine Rouphael, Benjamin A Pinsky, Daniel C Douek, Jens Wrammert, Alberto Moreno, Mehul S Suthar
The rapid emergence of divergent SARS-CoV-2 variants has led to an update of the COVID-19 booster vaccine to a monovalent version containing the XBB.1.5 spike. To determine the neutralization breadth following booster immunization, we collected blood samples from 24 individuals pre- and post-XBB.1.5 mRNA booster vaccination (∼1 month). The XBB.1.5 booster improved both neutralizing activity against the ancestral SARS-CoV-2 strain (WA1) and the circulating Omicron variants, including EG.5.1, HK.3, HV...
February 5, 2024: bioRxiv
https://read.qxmd.com/read/38348899/proceed-with-caution-standard-protocol-exercise-stress-tests-fail-to-replicate-the-diagnostic-utility-of-supine-stand-tests-for-long-qt-syndrome
#15
JOURNAL ARTICLE
Alexa M Pinsky, Veda K Kulkarni, J Martijn Bos, Raquel Neves, Thomas G Allison, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) is a sudden death predisposing condition characterized by ECG-derived prolongation of the QT interval. Previous studies have demonstrated that the supine-stand test may aid in the diagnosis of LQTS as patients fail to shorten their QT interval in response to standing up. The aim of this study was to evaluate the diagnostic accuracy of ECG data derived from standard protocol, clinically performed treadmill exercise stress tests (TESTs) in their ability to mimic the formal supine-stand test...
February 13, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38335364/%C3%AF-2s-suppression-in-pb-pb-collisions-at-the-lhc
#16
JOURNAL ARTICLE
S Acharya, D Adamová, A Adler, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, S Ahmad, S U Ahn, I Ahuja, A Akindinov, M Al-Turany, D Aleksandrov, B Alessandro, H M Alfanda, R Alfaro Molina, B Ali, A Alici, N Alizadehvandchali, A Alkin, J Alme, G Alocco, T Alt, I Altsybeev, M N Anaam, C Andrei, A Andronic, V Anguelov, F Antinori, P Antonioli, N Apadula, L Aphecetche, H Appelshäuser, C Arata, S Arcelli, M Aresti, R Arnaldi, I C Arsene, M Arslandok, A Augustinus, R Averbeck, M D Azmi, A Badalà, J Bae, Y W Baek, X Bai, R Bailhache, Y Bailung, A Balbino, A Baldisseri, B Balis, D Banerjee, Z Banoo, R Barbera, F Barile, L Barioglio, M Barlou, G G Barnaföldi, L S Barnby, V Barret, L Barreto, C Bartels, K Barth, E Bartsch, F Baruffaldi, N Bastid, S Basu, G Batigne, D Battistini, B Batyunya, D Bauri, J L Bazo Alba, I G Bearden, C Beattie, P Becht, D Behera, I Belikov, A D C Bell Hechavarria, F Bellini, R Bellwied, S Belokurova, V Belyaev, G Bencedi, S Beole, A Bercuci, Y Berdnikov, A Berdnikova, L Bergmann, M G Besoiu, L Betev, P P Bhaduri, A Bhasin, M A Bhat, B Bhattacharjee, L Bianchi, N Bianchi, J Bielčík, J Bielčíková, J Biernat, A P Bigot, A Bilandzic, G Biro, S Biswas, N Bize, J T Blair, D Blau, M B Blidaru, N Bluhme, C Blume, G Boca, F Bock, T Bodova, A Bogdanov, S Boi, J Bok, L Boldizsár, A Bolozdynya, M Bombara, P M Bond, G Bonomi, H Borel, A Borissov, A G Borquez Carcamo, H Bossi, E Botta, Y E M Bouziani, L Bratrud, P Braun-Munzinger, M Bregant, M Broz, G E Bruno, D Budnikov, H Buesching, S Bufalino, O Bugnon, P Buhler, Z Buthelezi, S A Bysiak, M Cai, H Caines, A Caliva, E Calvo Villar, J M M Camacho, P Camerini, F D M Canedo, M Carabas, A A Carballo, F Carnesecchi, R Caron, J Castillo Castellanos, F Catalano, C Ceballos Sanchez, I Chakaberia, P Chakraborty, S Chandra, S Chapeland, M Chartier, S Chattopadhyay, S Chattopadhyay, T G Chavez, T Cheng, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, E S Chizzali, J Cho, S Cho, P Chochula, P Christakoglou, C H Christensen, P Christiansen, T Chujo, M Ciacco, C Cicalo, F Cindolo, M R Ciupek, G Clai, F Colamaria, J S Colburn, D Colella, M Colocci, M Concas, G Conesa Balbastre, Z Conesa Del Valle, G Contin, J G Contreras, M L Coquet, T M Cormier, P Cortese, M R Cosentino, F Costa, S Costanza, J Crkovská, P Crochet, R Cruz-Torres, E Cuautle, P Cui, A Dainese, M C Danisch, A Danu, P Das, P Das, S Das, A R Dash, S Dash, A De Caro, G de Cataldo, J de Cuveland, A De Falco, D De Gruttola, N De Marco, C De Martin, S De Pasquale, S Deb, R J Debski, K R Deja, R Del Grande, L Dello Stritto, W Deng, P Dhankher, D Di Bari, A Di Mauro, R A Diaz, T Dietel, Y Ding, R Divià, D U Dixit, Ø Djuvsland, U Dmitrieva, A Dobrin, B Dönigus, J M Dubinski, A Dubla, S Dudi, P Dupieux, M Durkac, N Dzalaiova, T M Eder, R J Ehlers, V N Eikeland, F Eisenhut, D Elia, B Erazmus, F Ercolessi, F Erhardt, M R Ersdal, B Espagnon, G Eulisse, D Evans, S Evdokimov, L Fabbietti, M Faggin, J Faivre, F Fan, W Fan, A Fantoni, M Fasel, P Fecchio, A Feliciello, G Feofilov, A Fernández Téllez, L Ferrandi, M B Ferrer, A Ferrero, C Ferrero, A Ferretti, V J G Feuillard, V Filova, D Finogeev, F M Fionda, F Flor, A N Flores, S Foertsch, I Fokin, S Fokin, E Fragiacomo, E Frajna, U Fuchs, N Funicello, C Furget, A Furs, T Fusayasu, J J Gaardhøje, M Gagliardi, A M Gago, C D Galvan, D R Gangadharan, P Ganoti, C Garabatos, J R A Garcia, E Garcia-Solis, K Garg, C Gargiulo, A Garibli, K Garner, P Gasik, A Gautam, M B Gay Ducati, M Germain, C Ghosh, M Giacalone, P Giubellino, P Giubilato, A M C Glaenzer, P Glässel, E Glimos, D J Q Goh, V Gonzalez, L H González-Trueba, M Gorgon, S Gotovac, V Grabski, L K Graczykowski, E Grecka, A Grelli, C Grigoras, V Grigoriev, S Grigoryan, F Grosa, J F Grosse-Oetringhaus, R Grosso, D Grund, G G Guardiano, R Guernane, M Guilbaud, K Gulbrandsen, T Gundem, T Gunji, W Guo, A Gupta, R Gupta, S P Guzman, L Gyulai, M K Habib, C Hadjidakis, F U Haider, H Hamagaki, A Hamdi, M Hamid, Y Han, R Hannigan, M R Haque, J W Harris, A Harton, H Hassan, D Hatzifotiadou, P Hauer, L B Havener, S T Heckel, E Hellbär, H Helstrup, M Hemmer, T Herman, G Herrera Corral, F Herrmann, S Herrmann, K F Hetland, B Heybeck, H Hillemanns, C Hills, B Hippolyte, B Hofman, B Hohlweger, G H Hong, M Horst, A Horzyk, R Hosokawa, Y Hou, P Hristov, C Hughes, P Huhn, L M Huhta, C V Hulse, T J Humanic, H Hushnud, A Hutson, D Hutter, J P Iddon, R Ilkaev, H Ilyas, M Inaba, G M Innocenti, M Ippolitov, A Isakov, T Isidori, M S Islam, M Ivanov, M Ivanov, V Ivanov, M Jablonski, B Jacak, N Jacazio, P M Jacobs, S Jadlovska, J Jadlovsky, S Jaelani, L Jaffe, C Jahnke, M J Jakubowska, M A Janik, T Janson, M Jercic, S Jia, A A P Jimenez, F Jonas, J M Jowett, J Jung, M Jung, A Junique, A Jusko, M J Kabus, J Kaewjai, P Kalinak, A S Kalteyer, A Kalweit, V Kaplin, A Karasu Uysal, D Karatovic, O Karavichev, T Karavicheva, P Karczmarczyk, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, B Ketzer, A M Khan, S Khan, A Khanzadeev, Y Kharlov, A Khatun, A Khuntia, M B Kidson, B Kileng, B Kim, C Kim, D J Kim, E J Kim, J Kim, J S Kim, J Kim, J Kim, M Kim, S Kim, T Kim, K Kimura, S Kirsch, I Kisel, S Kiselev, A Kisiel, J P Kitowski, J L Klay, J Klein, S Klein, C Klein-Bösing, M Kleiner, T Klemenz, A Kluge, A G Knospe, C Kobdaj, T Kollegger, A Kondratyev, E Kondratyuk, J Konig, S A Konigstorfer, P J Konopka, G Kornakov, S D Koryciak, A Kotliarov, V Kovalenko, M Kowalski, V Kozhuharov, I Králik, A Kravčáková, L Kreis, M Krivda, F Krizek, K Krizkova Gajdosova, M Kroesen, M Krüger, D M Krupova, E Kryshen, V Kučera, C Kuhn, P G Kuijer, T Kumaoka, D Kumar, L Kumar, N Kumar, S Kumar, S Kundu, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, S Kushpil, J Kvapil, M J Kweon, J Y Kwon, Y Kwon, S L La Pointe, P La Rocca, Y S Lai, A Lakrathok, M Lamanna, R Langoy, P Larionov, E Laudi, L Lautner, R Lavicka, T Lazareva, R Lea, H Lee, G Legras, J Lehrbach, R C Lemmon, I León Monzón, M M Lesch, E D Lesser, M Lettrich, P Lévai, X Li, X L Li, J Lien, R Lietava, B Lim, S H Lim, V Lindenstruth, A Lindner, C Lippmann, A Liu, D H Liu, J Liu, I M Lofnes, C Loizides, S Lokos, P Loncar, J A Lopez, X Lopez, E López Torres, P Lu, J R Luhder, M Lunardon, G Luparello, Y G Ma, A Maevskaya, M Mager, T Mahmoud, A Maire, M V Makariev, M Malaev, G Malfattore, N M Malik, Q W Malik, S K Malik, L Malinina, D Mal'Kevich, D Mallick, N Mallick, G Mandaglio, V Manko, F Manso, V Manzari, Y Mao, G V Margagliotti, A Margotti, A Marín, C Markert, P Martinengo, J L Martinez, M I Martínez, G Martínez García, S Masciocchi, M Masera, A Masoni, L Massacrier, A Mastroserio, A M Mathis, O Matonoha, P F T Matuoka, A Matyja, C Mayer, A L Mazuecos, F Mazzaschi, M Mazzilli, J E Mdhluli, A F Mechler, Y Melikyan, A Menchaca-Rocha, E Meninno, A S Menon, M Meres, S Mhlanga, Y Miake, L Micheletti, L C Migliorin, D L Mihaylov, K Mikhaylov, A N Mishra, D Miśkowiec, A Modak, A P Mohanty, B Mohanty, M Mohisin Khan, M A Molander, Z Moravcova, C Mordasini, D A Moreira De Godoy, I Morozov, A Morsch, T Mrnjavac, V Muccifora, S Muhuri, J D Mulligan, A Mulliri, M G Munhoz, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, J W Myrcha, B Naik, A I Nambrath, B K Nandi, R Nania, E Nappi, A F Nassirpour, A Nath, C Nattrass, M N Naydenov, A Neagu, A Negru, L Nellen, S V Nesbo, G Neskovic, D Nesterov, B S Nielsen, E G Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, S Noh, P Nomokonov, J Norman, N Novitzky, P Nowakowski, A Nyanin, J Nystrand, M Ogino, A Ohlson, V A Okorokov, J Oleniacz, A C Oliveira Da Silva, M H Oliver, A Onnerstad, C Oppedisano, A Ortiz Velasquez, J Otwinowski, M Oya, K Oyama, Y Pachmayer, S Padhan, D Pagano, G Paić, A Palasciano, S Panebianco, H Park, H Park, J Park, J E Parkkila, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, M Pennisi, L G Pereira, D Peresunko, G M Perez, S Perrin, Y Pestov, V Petráček, V Petrov, M Petrovici, R P Pezzi, S Piano, M Pikna, P Pillot, O Pinazza, L Pinsky, C Pinto, S Pisano, M Płoskoń, M Planinic, F Pliquett, M G Poghosyan, B Polichtchouk, S Politano, N Poljak, A Pop, S Porteboeuf-Houssais, V Pozdniakov, K K Pradhan, S K Prasad, S Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, S Pucillo, Z Pugelova, S Qiu, L Quaglia, R E Quishpe, S Ragoni, A Rakotozafindrabe, L Ramello, F Rami, S A R Ramirez, T A Rancien, M Rasa, S S Räsänen, R Rath, M P Rauch, I Ravasenga, K F Read, C Reckziegel, A R Redelbach, K Redlich, A Rehman, F Reidt, H A Reme-Ness, Z Rescakova, K Reygers, A Riabov, V Riabov, R Ricci, M Richter, A A Riedel, W Riegler, C Ristea, M Rodríguez Cahuantzi, K Røed, R Rogalev, E Rogochaya, T S Rogoschinski, D Rohr, D Röhrich, P F Rojas, S Rojas Torres, P S Rokita, G Romanenko, F Ronchetti, A Rosano, E D Rosas, A Rossi, A Roy, S Roy, N Rubini, O V Rueda, D Ruggiano, R Rui, B Rumyantsev, P G Russek, R Russo, A Rustamov, E Ryabinkin, Y Ryabov, A Rybicki, H Rytkonen, W Rzesa, O A M Saarimaki, R Sadek, S Sadhu, S Sadovsky, J Saetre, K Šafařík, S K Saha, S Saha, B Sahoo, R Sahoo, S Sahoo, D Sahu, P K Sahu, J Saini, K Sajdakova, S Sakai, M P Salvan, S Sambyal, I Sanna, T B Saramela, D Sarkar, N Sarkar, P Sarma, V Sarritzu, V M Sarti, M H P Sas, J Schambach, H S Scheid, C Schiaua, R Schicker, A Schmah, C Schmidt, H R Schmidt, M O Schmidt, M Schmidt, N V Schmidt, A R Schmier, R Schotter, A Schröter, J Schukraft, K Schwarz, K Schweda, G Scioli, E Scomparin, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, S Senyukov, J J Seo, D Serebryakov, L Šerkšnytė, A Sevcenco, T J Shaba, A Shabetai, R Shahoyan, A Shangaraev, A Sharma, D Sharma, H Sharma, M Sharma, S Sharma, S Sharma, U Sharma, A Shatat, O Sheibani, K Shigaki, M Shimomura, J Shin, S Shirinkin, Q Shou, Y Sibiriak, S Siddhanta, T Siemiarczuk, T F Silva, D Silvermyr, T Simantathammakul, R Simeonov, B Singh, B Singh, R Singh, R Singh, R Singh, S Singh, V K Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, G Skorodumovs, M Slupecki, N Smirnov, R J M Snellings, E H Solheim, J Song, A Songmoolnak, F Soramel, R Spijkers, I Sputowska, J Staa, J Stachel, I Stan, P J Steffanic, S F Stiefelmaier, D Stocco, I Storehaug, P Stratmann, S Strazzi, C P Stylianidis, A A P Suaide, C Suire, M Sukhanov, M Suljic, R Sultanov, V Sumberia, S Sumowidagdo, S Swain, I Szarka, S F Taghavi, G Taillepied, J Takahashi, G J Tambave, S Tang, Z Tang, J D Tapia Takaki, N Tapus, L A Tarasovicova, M G Tarzila, G F Tassielli, A Tauro, G Tejeda Muñoz, A Telesca, L Terlizzi, C Terrevoli, G Tersimonov, S Thakur, D Thomas, A Tikhonov, A R Timmins, M Tkacik, T Tkacik, A Toia, R Tokumoto, N Topilskaya, M Toppi, F Torales-Acosta, T Tork, A G Torres Ramos, A Trifiró, A S Triolo, S Tripathy, T Tripathy, S Trogolo, V Trubnikov, W H Trzaska, T P Trzcinski, A Tumkin, R Turrisi, T S Tveter, K Ullaland, B Ulukutlu, A Uras, M Urioni, G L Usai, M Vala, N Valle, L V R van Doremalen, M van Leeuwen, C A van Veen, R J G van Weelden, P Vande Vyvre, D Varga, Z Varga, M Vasileiou, A Vasiliev, O Vázquez Doce, V Vechernin, E Vercellin, S Vergara Limón, L Vermunt, R Vértesi, M Verweij, L Vickovic, Z Vilakazi, O Villalobos Baillie, G Vino, A Vinogradov, T Virgili, V Vislavicius, A Vodopyanov, B Volkel, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, N Vozniuk, J Vrláková, C Wang, D Wang, Y Wang, A Wegrzynek, F T Weiglhofer, S C Wenzel, J P Wessels, S L Weyhmiller, J Wiechula, J Wikne, G Wilk, J Wilkinson, G A Willems, B Windelband, M Winn, J R Wright, W Wu, Y Wu, R Xu, A Yadav, A K Yadav, S Yalcin, Y Yamaguchi, K Yamakawa, S Yang, S Yano, Z Yin, I-K Yoo, J H Yoon, S Yuan, A Yuncu, V Zaccolo, C Zampolli, F Zanone, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, M Zhalov, B Zhang, L Zhang, S Zhang, X Zhang, Y Zhang, Z Zhang, M Zhao, V Zherebchevskii, Y Zhi, D Zhou, Y Zhou, J Zhu, Y Zhu, S C Zugravel, N Zurlo
The production of the ψ(2S) charmonium state was measured with ALICE in Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zero transverse momentum, at forward rapidity (2.5<y<4). The measurement of the ratio of the inclusive production cross sections of the ψ(2S) and J/ψ resonances is reported as a function of the centrality of the collisions and of transverse momentum, in the region p_{T}<12  GeV/c...
January 26, 2024: Physical Review Letters
https://read.qxmd.com/read/38304478/fetal-maceration-and-partial-retention-of-fetal-bones-in-2-mares
#17
Jennifer Morrissey, Tova Pinsky, Marie-France Roy
Pregnancy loss after Day 40 in mares usually results in the expulsion (abortion) of the fetus and placental membranes. However, fetal retention within the uterus is also a possible outcome, leading to either fetal mummification or maceration. Fetal maceration is septic decomposition of fetal tissues within the uterus following failure of expulsion. It requires the presence of bacteria and oxygen within the uterus, likely originating from an open cervix, and results in tissue autolysis, leaving only fetal bones remaining in the mare...
February 2024: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/38284144/is-human-height-based-on-a-lucas-sequence-relationship-between-the-foot-height-tibial-length-femur-length-and-upper-body-length
#18
JOURNAL ARTICLE
Dror Paley, Sahra Sutaria, Daelan Pinsky, Darin Roberts, Craig Robbins
This is a retrospective chart and radiographic review of 145 patients who underwent full-body EOS imaging; 109 males and 36 females. The mean ages of the female and male subsets are 28.8 (SD = 11.6) years and 29.5 (SD = 11.8) years, respectively. The sum of the foot height (Ft) and the tibial length (T) for each subject was compared to their femur length (Fe). Subsequently, the sum of the tibial (T) and femoral lengths (Fe) were compared to their respective upper body lengths (UB), as measured from the tops of the femoral heads...
January 29, 2024: Journal of Anatomy
https://read.qxmd.com/read/38276029/genetic-analysis-of-candida-albicans-filamentation-by-the-iron-chelator-bps-reveals-a-role-for-a-conserved-kinase-wd40-protein-pair
#19
JOURNAL ARTICLE
Mariel Pinsky, Daniel Kornitzer
Candida albicans is a major human pathogenic fungus that is distinguished by its capability to switch from a yeast to a hyphal morphology under different conditions. Here, we analyze the cellular effects of high concentrations of the iron chelator bathophenanthroline disulfonate (BPS). BPS inhibits cellular growth by withholding iron, but when iron chelation is overcome by the addition of hemoglobin as an iron source, the cells resume growth as hyphae. The BPS hyphal induction pathway was characterized by identifying the hyphal-specific transcription factors that it requires and by a forward genetic screen for mutants that fail to form hyphae in BPS using a transposon library generated in a haploid strain...
January 22, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38193738/discovering-the-clinical-relevance-of-heart-lung-interactions
#20
JOURNAL ARTICLE
Michael R Pinsky
In 1978, Dr. Pinsky's scientific career became firmly directed toward understanding the deeper meaning of heart-lung interactions. This would define his focus for the next 45 yr. At the time, he and colleagues studied the effects of changes in intrathoracic pressure on left ventricular performance in humans, documenting that the primary effect of large negative swings in intrathoracic pressure was to increase left ventricular transmural ejection pressure, and thus left ventricular afterload, selectively. They concluded that large intrathoracic pressure changes directly influence cardiac performance...
February 1, 2024: Anesthesiology
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