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Upper Urinary Tract Cancer

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https://www.readbyqxmd.com/read/29281857/outcomes-of-subsequent-non-muscle-invasive-bladder-cancer-treated-with-intravesical-bacillus-calmette-gu%C3%A3-rin-after-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-carcinoma-a-propensity-matched-analysis-with-primary-bladder-cancer
#1
Makito Miyake, Yoshihiro Tatsumi, Hiroaki Matsumoto, Kazuhiro Nagao, Hideyasu Matsuyama, Teruo Inamoto, Haruhito Azuma, Hiroaki Yasumoto, Hiroaki Shiina, Kiyohide Fujimoto
OBJECTIVES: To describe the clinicopathologic characteristics and prognosis of subsequent non-muscle invasive bladder cancer (NMIBC) after radical nephroureterectomy for upper urinary tract urothelial carcinoma (UTUC), particularly its response to intravesical Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS: An observational study was conducted in 1463 patients with UTUC who had undergone radical nephroureterectomy and in 1555 patients with primary NMIBC. Of the 1463 UTUC patients, 256 (17%) subsequently developed NMIBC (UTUC-NMIBC) and were available for the analysis...
December 27, 2017: BJU International
https://www.readbyqxmd.com/read/29241314/perioperative-antithrombotic-therapy-in-patients-undergoing-endoscopic-urologic-surgery-where-do-we-stand-with-current-literature
#2
Richard Naspro, Lori B Lerner, Roberta Rossini, Michele Manica, Henry H Woo, Ross J Calopedos, Cecilia M Cracco, Cesare M Scoffone, Thomas R Herrmann, Jean J de la Rosette, Jean-Nicolas Cornu, Luigi F DA Pozzo
INTRODUCTION: The number of patients on chronic anticoagulant or antiplatelet therapy requiring endoscopic urological surgery is increasing worldwide. Therefore, there is a strong demand to standardize the peri-operative treatment of this cohort of patients, both from a surgical and cardiological point of view, balancing the risks of bleeding versus thrombosis, and the important possible clinical and medical legal repercussions therein. EVIDENCE ACQUISITION: Although literature is scarce and the quality of evidence quite low, in line with other surgical specialties, guidelines and recommendations for the management of urological patients have begun to emerge...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29234538/can-androgen-deprivation-therapy-obviate-the-need-of-channel-transurethral-resection-of-the-prostate-in-advanced-prostate-cancer-with-urinary-retention-a-prospective-study
#3
Rajeev Sood, Ritesh Kumar Singh, Hemant Goel, T Manasa, Nikhil Khattar, Mahesh C Tripathi
Objective: To evaluate the efficacy of androgen-deprivation therapy (ADT) in relieving urinary retention in patients with advanced prostate cancer presenting with urinary retention or a high post-void residual urine volume (PVR). Patients and methods: Patients with advanced prostate cancer with an indwelling catheter for acute/chronic urinary retention, or with a high PVR (>200 mL) who had not received any previous treatment were included in the study. Patients with localised prostate cancer eligible for receiving any therapy aimed at cure were excluded...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29195499/adjuvant-chemotherapy-improves-survival-of-patients-with-high-risk-upper-urinary-tract-urothelial-carcinoma-a-propensity-score-matched-analysis
#4
Kazutoshi Fujita, Kei Taneishi, Teruo Inamoto, Yu Ishizuya, Shingo Takada, Masao Tsujihata, Go Tanigawa, Noriko Minato, Shigeaki Nakazawa, Tsuyoshi Takada, Toshichika Iwanishi, Motohide Uemura, Yasushi Okuno, Haruhito Azuma, Nonomura Norio
BACKGROUND: The purposes of this study were to determine whether adjuvant chemotherapy (AC) improved the prognosis of patients with high-risk upper urinary tract urothelial carcinoma (UTUC)and to identify the patients who benefited from AC. METHODS: Among a multi-center database of 1014 patients who underwent RNU for UTUC, 344 patients with ≥ pT3 or the presence of lymphovascular invasion (LVI) were included. Cancer-specific survival (CSS) estimates were calculated by the Kaplan-Meier method, and groups were compared by the log-rank test...
December 1, 2017: BMC Urology
https://www.readbyqxmd.com/read/29191437/urinary-diversion-in-the-genitourinary-cancer-survivor
#5
REVIEW
Omari K Johnson, Andrew Berchuck, Angeles A Secord, Andrew C Peterson
Urinary diversion has been in the scope of practice of Gynecologic Oncologists since the inception of the sub-specialty. However, many fewer urinary diversions are performed currently than in the past due to improved prevention of cervical cancer. The intent of this article is to provide a state of the art review for Gynecologic Oncologists. Surgeons performing these complex procedures must be knowledgeable about the differences between various types of continent and non-continent urinary diversions, and the principles of pre and post-operative care...
November 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29185045/preoperative-chronic-kidney-disease-is-predictive-of-oncological-outcome-of-radical-cystectomy-for-bladder-cancer
#6
Akihiko Matsumoto, Tohru Nakagawa, Atsushi Kanatani, Masaomi Ikeda, Taketo Kawai, Jimpei Miyakawa, Satoru Taguchi, Akihiro Naito, Masafumi Otsuka, Yasukazu Nakanishi, Motofumi Suzuki, Fumitaka Koga, Yasushi Nagase, Yasushi Kondo, Toshikazu Okaneya, Yoshinori Tanaka, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes after radical cystectomy (RC) for bladder cancer. METHODS: We reviewed the medical records of patients with urothelial bladder carcinoma who underwent RC with curative intent at seven hospitals between 1990 and 2013. After excluding patients with a history of upper urinary tract urothelial cancer or neoadjuvant chemotherapy, we analyzed 594 cases for the study. Preoperative estimated glomerular filtration rate (eGFR) was calculated using the three-variable Japanese equation for GFR estimation from serum creatinine level and age...
November 28, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29182902/a-clinical-case-of-perineal-invasion-from-rectal-carcinoma
#7
A Mitrushi, S Bilali, V Bilali, F Mitrushi, E Mehmeti
We report a case of 62-year old women with skin infiltration in the perineal area after anterior rectal resection due to upper rectal cancer. Computed Tomography (CT) shows an intense infiltrative aspect of the lesion. The patient had a diffuse perineal infiltration predominantly at Levator Ani muscles and adhesions to the posterior parts of urinary bladder, uterus, vagina and perineal skin. The patient underwent surgery with colostomy to relieve the colonic tract due to obstruction and later was treated with chemo-radiation...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29177431/significance-of-preoperative-butyrylcholinesterase-level-as-an-independent-predictor-of-survival-in-patients-with-upper-urinary-tract-urothelial-carcinoma-treated-with-nephroureterectomy
#8
Daisuke Noro, Takuya Koie, Yasuhiro Hashimoto, Toshikazu Tanaka, Chikara Ohyama, Yuki Tobisawa, Tohru Yoneyama, Atsushi Imai, Shingo Hatakeyama, Hayato Yamamoto, Masato Kitayama, Kazuyoshi Hirota
Objectives: Butyrylcholinesterase (BChE) is an alpha-glycoprotein synthesized in the liver. Its serum levels are reportedly correlated with disease activity in patients with cancer. The aim of this study was to estimate the potential prognostic significance of preoperative serum BChE levels in patients with upper urinary tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). Methods: Of the 220 patients with UTUC who underwent RNU between 1995 and 2016 at Hirosaki University Hospital, 149 patients with available laboratory data were included for analysis...
November 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29164703/clinicopathological-characteristics-of-patients-with-upper-urinary-tract-urothelial-cancer-with-loss-of-immunohistochemical-expression-of-the-dna-mismatch-repair-proteins-in-universal-screening
#9
Shinji Urakami, Naoko Inoshita, Suguru Oka, Yu Miyama, Sachio Nomura, Masami Arai, Kazushige Sakaguchi, Kazuhiro Kurosawa, Toshikazu Okaneya
OBJECTIVES: To assess the detection rate of putative Lynch syndrome-associated upper urinary tract urothelial cancer among all upper urinary tract urothelial cancers and to examine its clinicopathological characteristics. METHODS: A total of 143 patients with upper urinary tract urothelial cancer who had received total nephroureterectomy were immunohistochemically stained for the expression of mismatch repair proteins MLH1, PMS2, MSH2 and MSH6. For all suspected mismatch repair-deficient cases, MMR genetic testing was recommended and clinicopathological features were examined...
November 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29141603/detect-i-detect-ii-a-study-protocol-for-a-prospective-multicentre-observational-study-to-validate-the-uromark-assay-for-the-detection-of-bladder-cancer-from-urinary-cells
#10
Wei Shen Tan, Andrew Feber, Liqin Dong, Rachael Sarpong, Sheida Rezaee, Simon Rodney, Pramit Khetrapal, Patricia de Winter, Frelyn Ocampo, Rumana Jalil, Norman R Williams, Chris Brew-Graves, John D Kelly
BACKGROUND: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. We have developed the UroMark assay, which can detect 150 methylation specific alteration specific to bladder cancer using DNA from urinary sediment cells...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29137333/preoperative-chronic-kidney-disease-predicts-poor-oncological-outcomes-after-radical-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#11
Hirotake Kodama, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Go Anan, Ken Fukushi, Takuma Narita, Toshikazu Tanaka, Yuka Kubota, Hirotaka Horiguchi, Masaki Momota, Koichi Kido, Teppei Matsumoto, Osamu Soma, Itsuto Hamano, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Atsushi Sasaki, Toshiaki Kawaguchi, Makoto Sato, Chikara Ohyama
Objective: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes in patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy. Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between February 1995 and February 2017 were retrospectively examined. Oncological outcomes, including intravesical recurrence-free, visceral recurrence-free, cancer-specific, and overall survival rates (intravesical RFS, visceral RFS, CSS, and OS, respectively) stratified by preoperative CKD status (CKD vs...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29094888/bladder-cancer-diagnosis-and-treatment
#12
REVIEW
Katharine C DeGeorge, Harry R Holt, Stephanie C Hodges
Bladder cancer is the sixth most prevalent malignancy in the United States and causes more than 16,000 deaths annually. The most common clinical presentation is asymptomatic hematuria, which should prompt evaluation with cystoscopy, renal function testing, and upper urinary tract imaging in adults 35 years and older and in those with irritative voiding symptoms, risk factors for bladder cancer, or gross hematuria at any age. Transurethral resection of the bladder tumor allows for definitive diagnosis, staging, and primary treatment...
October 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29072851/cervical-cancer-treated-with-reduced-volume-intensity-modulated-radiation-therapy-base-on-sedlis-criteria-nccn-vs-rtog
#13
Hua-Chun Luo, Gui-Shan Lin, Shao-Guang Liao, Feng-Mei Wang, Hui-Hua Cheng, Jing Feng, Qin Yin, Qun-Hua Chen, Jin-Feng Zhu, Jian-Feng Xu, Dian Wang, Zhi-Chao Fu
OBJECTIVE: This study aimed to evaluate the clinical efficacy of different target volumes in pelvic radiotherapy in postoperative treatment of cervical cancer based on the Sedlis criteria. METHODS: Patients who admitted to our department for postoperative radiotherapy of cervical cancer from December 2001 to December 2011 and met the Sedlis criteria were retrospectively analyzed. The incidences of acute and late radiation injuries, and overall, disease-free, and tumor-specific survival with reduced-volume pelvic and whole-pelvis radiotherapy were evaluated and compared...
October 26, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29037861/biologic-behavior-and-long-term-outcomes-of-carcinoma-in-situ-in-upper-urinary-tract-managed-by-radical-nephroureterectomy
#14
Teruo Inamoto, Hideyasu Matsuyama, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma
BACKGROUND AND OBJECTIVES: Carcinoma in situ (CIS) in urothelial carcinoma generally has poor prognosis, but the outcomes of pure/primary CIS tumor (p-CIS) and the behavior of concomitant CIS (c-CIS) with pTa-pT4 upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy has not been specified. The aim of our study was to explore the biological and prognostic features of c-CIS, compared with p-CIS. PATIENTS AND METHODS: We queried multicenter UTUC database...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29029534/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#15
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027273/molecular-diagnosis-of-lymph-node-metastasis-in-patients-with-upper-urinary-tract-cancer-who-underwent-lymphadenectomy
#16
Yoshiki Kodama, Tsunenori Kondo, Nagahide Matsumura, Toshio Shimokawa, Yasuo Kohjimoto, Kazunari Tanabe, Isao Hara
OBJECTIVES: To determine the significance of molecular diagnosis of lymph node metastasis using quantitative reverse transcription polymerase chain reaction in patients with upper urinary tract urothelial cancer. METHODS: A total of 51 patients with upper urinary tract urothelial cancer who underwent extended lymphadenectomy were included in the present study. Retrieved lymph nodes from each patient were divided into two parts. One part was assessed by quantitative reverse transcription polymerase chain reaction assay for molecular staging, whereas the other one was assessed by routine histopathological examination...
November 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29027264/editorial-comment-to-molecular-diagnosis-of-lymph-node-metastasis-in-patients-with-upper-urinary-tract-cancer-who-underwent-lymphadenectomy
#17
Riccardo Schiavina, Lorenzo Bianchi, Eugenio Brunocilla
No abstract text is available yet for this article.
November 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28988782/predictors-of-genitourinary-malignancy-in-patients-with-asymptomatic-microscopic-hematuria
#18
Patrick Samson, Nikhil Waingankar, Paras Shah, Derek Friedman, Louis Kavoussi, Justin Han
OBJECTIVES: To report the incidence of genitourinary malignancy and identify associated risk factors in patients undergoing urologic evaluation for asymptomatic microscopic hematuria (AMH) according to the 2012 American Urologic Association guidelines. SUBJECTS/PATIENTS AND METHODS: A retrospective institutional review of patients who underwent evaluation for AMH between 2012 and 2015 was conducted. Covariates analyzed included age, sex, smoking status, history of other malignancy, history of pelvic irradiation, presence of irritative voiding symptoms, use of anticoagulation, number of red blood cells on microscopic urinalysis, and guideline adherence...
October 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28978171/prognostic-scores-based-on-the-preoperative-plasma-fibrinogen-and-serum-albumin-level-as-a-prognostic-factor-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#19
Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang, Benkang Shi
This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977980/prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-urothelial-carcinoma-of-the-upper-urinary-tract-and-bladder-a-systematic-review-and-meta-analysis
#20
Xintao Li, Xin Ma, Lu Tang, Baojun Wang, Luyao Chen, Fan Zhang, Xu Zhang
The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that has prognostic value for various tumors, but its prognostic value in urothelial carcinoma (UC) remains controversial. This meta-analysis investigated the prognostic value of NLR in UC. A systematic search was performed on PubMed, ISI Web of Science, and Embase for studies focusing on the association between NLR and clinical features or prognosis of UC and published until November 2016. Prognostic outcomes and clinical features were collected and analyzed...
September 22, 2017: Oncotarget
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