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Upper Urinary Tract Cancer

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https://www.readbyqxmd.com/read/29164703/clinicopathological-characteristics-of-patients-with-upper-urinary-tract-urothelial-cancer-with-loss-of-immunohistochemical-expression-of-the-dna-mismatch-repair-proteins-in-universal-screening
#1
Shinji Urakami, Naoko Inoshita, Suguru Oka, Yu Miyama, Sachio Nomura, Masami Arai, Kazushige Sakaguchi, Kazuhiro Kurosawa, Toshikazu Okaneya
OBJECTIVES: To assess the detection rate of putative Lynch syndrome-associated upper urinary tract urothelial cancer among all upper urinary tract urothelial cancers and to examine its clinicopathological characteristics. METHODS: A total of 143 patients with upper urinary tract urothelial cancer who had received total nephroureterectomy were immunohistochemically stained for the expression of mismatch repair proteins MLH1, PMS2, MSH2 and MSH6. For all suspected mismatch repair-deficient cases, MMR genetic testing was recommended and clinicopathological features were examined...
November 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29141603/detect-i-detect-ii-a-study-protocol-for-a-prospective-multicentre-observational-study-to-validate-the-uromark-assay-for-the-detection-of-bladder-cancer-from-urinary-cells
#2
Wei Shen Tan, Andrew Feber, Liqin Dong, Rachael Sarpong, Sheida Rezaee, Simon Rodney, Pramit Khetrapal, Patricia de Winter, Frelyn Ocampo, Rumana Jalil, Norman R Williams, Chris Brew-Graves, John D Kelly
BACKGROUND: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. We have developed the UroMark assay, which can detect 150 methylation specific alteration specific to bladder cancer using DNA from urinary sediment cells...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29137333/preoperative-chronic-kidney-disease-predicts-poor-oncological-outcomes-after-radical-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#3
Hirotake Kodama, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Go Anan, Ken Fukushi, Takuma Narita, Toshikazu Tanaka, Yuka Kubota, Hirotaka Horiguchi, Masaki Momota, Koichi Kido, Teppei Matsumoto, Osamu Soma, Itsuto Hamano, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Atsushi Sasaki, Toshiaki Kawaguchi, Makoto Sato, Chikara Ohyama
Objective: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes in patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy. Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between February 1995 and February 2017 were retrospectively examined. Oncological outcomes, including intravesical recurrence-free, visceral recurrence-free, cancer-specific, and overall survival rates (intravesical RFS, visceral RFS, CSS, and OS, respectively) stratified by preoperative CKD status (CKD vs...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29094888/bladder-cancer-diagnosis-and-treatment
#4
Katharine C DeGeorge, Harry R Holt, Stephanie C Hodges
Bladder cancer is the sixth most prevalent malignancy in the United States and causes more than 16,000 deaths annually. The most common clinical presentation is asymptomatic hematuria, which should prompt evaluation with cystoscopy, renal function testing, and upper urinary tract imaging in adults 35 years and older and in those with irritative voiding symptoms, risk factors for bladder cancer, or gross hematuria at any age. Transurethral resection of the bladder tumor allows for definitive diagnosis, staging, and primary treatment...
October 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29072851/cervical-cancer-treated-with-reduced-volume-intensity-modulated-radiation-therapy-base-on-sedlis-criteria-nccn-vs-rtog
#5
Hua-Chun Luo, Gui-Shan Lin, Shao-Guang Liao, Feng-Mei Wang, Hui-Hua Cheng, Jing Feng, Qin Yin, Qun-Hua Chen, Jin-Feng Zhu, Jian-Feng Xu, Dian Wang, Zhi-Chao Fu
OBJECTIVE: This study aimed to evaluate the clinical efficacy of different target volumes in pelvic radiotherapy in postoperative treatment of cervical cancer based on the Sedlis criteria. METHODS: Patients who admitted to our department for postoperative radiotherapy of cervical cancer from December 2001 to December 2011 and met the Sedlis criteria were retrospectively analyzed. The incidences of acute and late radiation injuries, and overall, disease-free, and tumor-specific survival with reduced-volume pelvic and whole-pelvis radiotherapy were evaluated and compared...
October 26, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29037861/biologic-behavior-and-long-term-outcomes-of-carcinoma-in-situ-in-upper-urinary-tract-managed-by-radical-nephroureterectomy
#6
Teruo Inamoto, Hideyasu Matsuyama, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma
BACKGROUND AND OBJECTIVES: Carcinoma in situ (CIS) in urothelial carcinoma generally has poor prognosis, but the outcomes of pure/primary CIS tumor (p-CIS) and the behavior of concomitant CIS (c-CIS) with pTa-pT4 upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy has not been specified. The aim of our study was to explore the biological and prognostic features of c-CIS, compared with p-CIS. PATIENTS AND METHODS: We queried multicenter UTUC database...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29029534/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#7
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027273/molecular-diagnosis-of-lymph-node-metastasis-in-patients-with-upper-urinary-tract-cancer-who-underwent-lymphadenectomy
#8
Yoshiki Kodama, Tsunenori Kondo, Nagahide Matsumura, Toshio Shimokawa, Yasuo Kohjimoto, Kazunari Tanabe, Isao Hara
OBJECTIVES: To determine the significance of molecular diagnosis of lymph node metastasis using quantitative reverse transcription polymerase chain reaction in patients with upper urinary tract urothelial cancer. METHODS: A total of 51 patients with upper urinary tract urothelial cancer who underwent extended lymphadenectomy were included in the present study. Retrieved lymph nodes from each patient were divided into two parts. One part was assessed by quantitative reverse transcription polymerase chain reaction assay for molecular staging, whereas the other one was assessed by routine histopathological examination...
November 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29027264/editorial-comment-to-molecular-diagnosis-of-lymph-node-metastasis-in-patients-with-upper-urinary-tract-cancer-who-underwent-lymphadenectomy
#9
Riccardo Schiavina, Lorenzo Bianchi, Eugenio Brunocilla
No abstract text is available yet for this article.
November 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28988782/predictors-of-genitourinary-malignancy-in-patients-with-asymptomatic-microscopic-hematuria
#10
Patrick Samson, Nikhil Waingankar, Paras Shah, Derek Friedman, Louis Kavoussi, Justin Han
OBJECTIVES: To report the incidence of genitourinary malignancy and identify associated risk factors in patients undergoing urologic evaluation for asymptomatic microscopic hematuria (AMH) according to the 2012 American Urologic Association guidelines. SUBJECTS/PATIENTS AND METHODS: A retrospective institutional review of patients who underwent evaluation for AMH between 2012 and 2015 was conducted. Covariates analyzed included age, sex, smoking status, history of other malignancy, history of pelvic irradiation, presence of irritative voiding symptoms, use of anticoagulation, number of red blood cells on microscopic urinalysis, and guideline adherence...
October 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28978171/prognostic-scores-based-on-the-preoperative-plasma-fibrinogen-and-serum-albumin-level-as-a-prognostic-factor-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#11
Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang, Benkang Shi
This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977980/prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-urothelial-carcinoma-of-the-upper-urinary-tract-and-bladder-a-systematic-review-and-meta-analysis
#12
Xintao Li, Xin Ma, Lu Tang, Baojun Wang, Luyao Chen, Fan Zhang, Xu Zhang
The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that has prognostic value for various tumors, but its prognostic value in urothelial carcinoma (UC) remains controversial. This meta-analysis investigated the prognostic value of NLR in UC. A systematic search was performed on PubMed, ISI Web of Science, and Embase for studies focusing on the association between NLR and clinical features or prognosis of UC and published until November 2016. Prognostic outcomes and clinical features were collected and analyzed...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28924517/breast-cancer-metastases-to-the-gastrointestinal-tract-presenting-with-anemia-and-intra-abdominal-bleed
#13
Idrees Khan, Rehan Malik, Amina Khan, Salman Assad, Mehr Zahid, Muhammad Saad Sohail, Faizan Yasin, Ahmed H Qavi
Signet ring adenocarcinoma of the breast with synchronous metastasis to the gastrointestinal (GI) tract is a rare occurrence, typically presenting with abdominal pain, dyspepsia, or GI bleed. We report a case of metastatic breast cancer presenting with a complaint of anemia. A further diagnostic evaluation revealed generalized lymphadenopathy, nodular thickening of the urinary bladder wall, bone lesions, and enlarged pancreas. Biopsies from the lymph nodes, pancreatic biopsy, and bladder nodule all revealed a signet cell carcinoma...
July 6, 2017: Curēus
https://www.readbyqxmd.com/read/28923700/venous-thromboembolism-risk-in-patients-with-locoregional-urothelial-tract-tumors
#14
Jorge D Ramos, Jonathan T Wingate, Roman Gulati, Elizabeth R Plimack, Lauren C Harshman, Thomas Powles, Simon J Crabb, Guenter Niegisch, Joaquim Bellmunt, Sylvain Ladoire, Ugo De Giorgi, Syed Hussain, Ajjai S Alva, Jack Baniel, Neeraj Agarwal, Jonathan E Rosenberg, Ulka N Vaishampayan, Matthew D Galsky, Evan Y Yu
BACKGROUND: Venous thromboembolism (VTE) is common in cancer patients, but there is limited data on patients with urothelial tract tumors (UTT). We previously identified several associative factors for increased VTE rates in patients with metastatic UTT. In this study, we assessed the frequency, associative factors, and impact on survival of VTE in patients with locoregional UTT. METHODS: Patients with locoregional bladder, upper urinary tract, or urethral cancer were included in this multi-center study from 29 academic institutions...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28921833/guideline-of-guidelines-asymptomatic-microscopic-haematuria
#15
REVIEW
Brian J Linder, Edward J Bass, Hugh Mostafid, Stephen A Boorjian
OBJECTIVE: To review major organizational guidelines on the evaluation and management of asymptomatic microscopic haematuria (AMH). METHODS: This is a review of the haematuria guidelines from 1.) American Urological Association (AUA), 2.) consensus statement from the Canadian Urological Association, Canadian Urologic Oncology Group, and Bladder Cancer Canada, 3.) American College of Physicians (ACP), 4.) Joint Consensus Statement of the Renal Association (RA) and British Association of Urological Surgeons (BAUS), and 5...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28903527/efficacy-of-early-ureteral-ligation-on-prevention-of-intravesical-recurrence-after-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-carcinoma-a-prospective-single-arm-multicenter-clinical-trial
#16
Shinichi Yamashita, Akihiro Ito, Koji Mitsuzuka, Naomasa Ioritani, Shigeto Ishidoya, Yoshihiro Ikeda, Kenji Numahata, Kazuhiko Orikasa, Tatsuo Tochigi, Fumihiko Soma, Takashige Namima, Yoichi Arai
Objective: The rate of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma is high. Seeding upper urinary tract urothelial carcinoma cells onto the damaged bladder wall is considered to be one of the causes of intravesical recurrence after radical nephroureterectomy. We evaluated the utility of early ureteral ligation in preventing the intravesical recurrence. Methods: This prospective single-arm clinical trial included patients who underwent radical nephroureterectomy for upper urinary tract urothelial carcinoma in the Tohoku Urological Evidence-Based Medicine Study Group between 2012 and 2013...
September 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28867446/european-association-of-urology-guidelines-on-upper-urinary-tract-urothelial-carcinoma-2017-update
#17
Morgan Rouprêt, Marko Babjuk, Eva Compérat, Richard Zigeuner, Richard J Sylvester, Maximilian Burger, Nigel C Cowan, Paolo Gontero, Bas W G Van Rhijn, A Hugh Mostafid, Joan Palou, Shahrokh F Shariat
CONTEXT: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice. OBJECTIVE: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians. EVIDENCE ACQUISITION: The recommendations provided in the current guidelines are based on a thorough review of available UTUC guidelines and articles identified following a systematic search of Medline...
September 1, 2017: European Urology
https://www.readbyqxmd.com/read/28853106/prognostic-role-of-lymphovascular-invasion-in-patients-with-urothelial-carcinoma-of-the-upper-urinary-tract
#18
Manel Mellouli, Slim Charfi, Walid Smaoui, Rim Kallel, Abdelmajid Khabir, Mehdi Bouacida, Mohamed Nabil Mhiri, Tahya Sellami Boudawara
PURPOSE: To evaluate the impact of lymphovascular invasion on the prognosis of patients treated for upper urinary tract urothelial carcinomas. MATERIALS AND METHODS: Clinical records of 49 patients treated surgically at our institute for upper urinary tract urothelial carcinomas were reviewed retrospectively. LVI was defined as the presence of cancer cells within an endotheluim-lined space without underlying muscular walls. Actuarial survival curves were analysed by Kaplan-Meier method...
August 29, 2017: Urology Journal
https://www.readbyqxmd.com/read/28845943/-laparoscopic-cystoprostatvesiculeectomy-with-orthotopic-excentric-ileal-bladder-substitution
#19
P V Glybochko, Yu G Alyaev, E V Shpot', A M Pshi-Khachev, K M Mosyakova, A S Nikolaeva
There are numerous options for forming an orthotopic bladder by the source tissue and the shape of the urinary reservoir. In our practice, we use the technique reported by Karolinska Institute (Sweden). This technique allows us to form a neobladder most resembling the natural urinary bladder in the shape and volume. The article presents a clinical observation describing this technique in a 63 year old patient who was initially diagnosed with bladder cancer pT2N0M0G3 and underwent transurethral resection of the bladder wall with the tumor...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28816298/-multiple-endoscopy-for-the-treatment-of-upper-urinary-tract-calculi-following-ileal-conduit-a-case-report-and-literature-review
#20
B Wang, J F Ye, L Zhao, H Bi, J Lu, L L Ma
Upper urinary tract calculi with infection is a quite difficult acute urologic emergency. And what is more, upper urinary tract obstruction after radical cystectomy following urinary diversion may be fatal in the vulnerable patients with this kind of situation. Postoperative anatomy and other factors affect the upper urinary tract calculi, and urinary tract infection greatly increased the risk. But it is particularly difficult to handle with patients with poor general condition and septic shock treatment, so how to optimize the selection program is worth further studying...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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