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Upper Urinary Tract Cancer

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https://www.readbyqxmd.com/read/29733795/muscle-invasive-bladder-and-urethral-cancer-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-review-of-305-patients
#1
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Samer El-Halwagy
OBJECTIVE: Bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC) is a common disease. Although the incidence and risk factors for the development of noninvasive bladder tumor have been reported in many series, rare studies have reported on muscle invasive bladder cancer (MIBC) and its urethral recurrence. We aimed to report the incidence, risk factors and survival rate for the development of MIBC and urethral tumors after surgical management of UTUC. MATERIAL AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29731099/oncologic-outcomes-of-post-kidney-transplantation-superficial-urothelial-carcinoma
#2
G-L Huang, H-L Luo, Y-T Chen, Y-T Cheng
PURPOSE: To analyze the oncologic effect of post-kidney transplantation (KT) immunosuppressive status for end-stage renal disease (ESRD) patients with superficial urothelial carcinoma. METHODS: From 2010 to 2015, there were 106 ESRD patients with superficial urinary bladder urothelial carcinoma (UB-UC) and 68 ESRD patients with superficial upper urinary tract urothelial carcinoma (UT-UC) in a single institution. Oncologic outcomes including bladder cancer recurrences and systemic disease recurrences within 5 years were compared between patients with and without KT...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29716554/clinically-significant-association-of-elevated-expression-of-nuclear-factor-e2-related-factor-2-expression-with-higher-glucose-uptake-and-progression-of-upper-urinary-tract-cancer
#3
Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida, Takao Kamai
BACKGROUND: There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS), as well as having a vital role in tumor proliferation, invasion, and chemoresistance. It was also recently reported that Nrf2 supports cell proliferation by promoting metabolic activity. Thus, Nrf2 is involved in progression of cancer. Upper urinary tract urothelial carcinoma (UTUC) is a biologically aggressive tumor with high rates of recurrence and progression, resulting in a poor prognosis...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29702097/can-renal-and-bladder-ultrasound-replace-ct-urogram-in-patients-investigated-for-microscopic-hematuria
#4
Wei Shen Tan, Rachael Sarpong, Pramit Khetrapal, Simon Rodney, Hugh Mostafid, Joanne Cresswell, James Hicks, Abhay Rane, Alastair Henderson, Dawn Watson, Jacob Cherian, Norman Williams, Chris Brew-Graves, Andrew Feber, John D Kelly
PURPOSE: Computed tomography urogram (CTU) is recommended when investigating patients with hematuria. We determine the incidence of urinary tract cancer and compare the diagnostic accuracy of CTU and renal and bladder ultrasound (RBUS) at identifying urinary tract cancer. METHODS: The DETECT I study (clinicaltrials.gov NCT02676180) is a prospective observational study recruiting patients ≥18 years following a presentation of macroscopic or microscopic haematuria at 40 hospitals...
April 24, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29696234/reduce-bladder-cancer-recurrence-in-patients-treated-for-upper-urinary-tract-urothelial-carcinoma-the-rebacare-trial
#5
T van Doeveren, P J van Leeuwen, K K H Aben, M van der Aa, M Barendrecht, E R Boevé, E B Cornel, A G van der Heijden, K Hendricksen, W Hirdes, A Kooistra, B Kroon, A M Leliveld, R P Meijer, H van Melick, B Merks, T M de Reijke, P de Vries, L F A Wymenga, B Wijsman, J L Boormans
Background: Following radical nephro-ureterectomy for urothelial carcinoma of the upper urinary tract (UUT), the reported bladder recurrence rate of urothelial carcinoma is 22-47%. A single intravesical instillation of chemotherapy within 10 days following nephro-ureterectomy has the potential to decrease the risk of a bladder recurrence significantly. Despite recommendation by the European Association of Urology guideline to administer a single instillation postoperatively, the compliance rate is low because the risk of extravasation of chemotherapy...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29682178/prognostic-value-of-circulating-micrornas-in-upper-tract-urinary-carcinoma
#6
Ruth Montalbo, Laura Izquierdo, Mercedes Ingelmo-Torres, Juan José Lozano, David Capitán, Antonio Alcaraz, Lourdes Mengual
The identification of upper tract urinary carcinoma (UTUC) prognostic biomarkers is urgently needed to predict tumour progression. This study aimed to identify serum microRNAs (miRNAs) that may be useful as minimally invasive predictive biomarkers of tumour progression and survival in UTUC patients. To this end, 33 UTUC patients who underwent radical nephroureterectomy at the Hospital Clinic of Barcelona were prospectively included. Expression of 800 miRNAs was evaluated in serum samples from these patients using nCounter® miRNA Expression Assays...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29651327/performance-of-urinary-markers-for-detection-of-upper-tract-urothelial-carcinoma-is-upper-tract-urine-more-accurate-than-urine-from-the-bladder
#7
Simone Bier, Jörg Hennenlotter, Michael Esser, Sarah Mohrhardt, Steffen Rausch, Christian Schwentner, Moritz Maas, Susanne Deininger, Simon Walz, Jens Bedke, Arnulf Stenzl, Tilman Todenhöfer
Objectives: To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC). Patients and Methods: The study comprised 758 urine samples either collected from the bladder ( n = 373) or UUT ( n = 385). All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy. Cytology, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and nuclear matrix protein 22 (NMP22) were performed...
2018: Disease Markers
https://www.readbyqxmd.com/read/29650141/adjuvant-therapy-in-muscle-invasive-bladder-cancer-and-upper-tract-urothelial-carcinoma
#8
REVIEW
Tala Achkar, Rahul A Parikh
This article summarizes the role of adjuvant chemotherapy in muscle-invasive and transitional cell carcinoma of the bladder and upper urinary tract.
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650139/follow-up-management-of-cystectomy-patients
#9
REVIEW
Madhumitha Reddy, Karim Kader
Bladder cancer is the sixth leading cancer in the United States. Radical cystectomy is a lifesaving procedure for bladder cancer with or without muscle invasion. Radical cystectomy is performed on 39% of these patients, and 35% will have a life-threatening recurrence. Distant metastases are the most common; local, upper tract, and urethral recurrence can also occur. Surveillance after cystectomy is critical to diagnosing recurrence early. Functional complications after urinary diversion include bowel dysfunction, vitamin B12 deficiency, acidosis, electrolyte abnormalities, osteopenia, nephrolithiasis, urinary tract infections, renal functional decline, and urinary obstruction, which can be reversed when diagnosed early...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650132/optimal-timing-of-chemotherapy-and-surgery-in-patients-with-muscle-invasive-bladder-cancer-and-upper-urinary-tract-urothelial-carcinoma
#10
REVIEW
William Tabayoyong, Roger Li, Jianjun Gao, Ashish Kamat
Radical cystectomy with bilateral pelvic lymph node dissection is the standard of care for patients with clinically localized muscle-invasive bladder cancer. Survival after radical cystectomy is associated with final pathologic staging. Survival decreases with increasing pT stage because of the presence of occult micrometastases, indicating the need for systemic chemotherapy. Systemic chemotherapy is delivered as either neoadjuvant therapy preoperatively, or as adjuvant therapy postoperatively. This article reviews the evidence for neoadjuvant and adjuvant chemotherapy for the treatment of muscle-invasive bladder and upper tract urothelial cancer and offers recommendations based on these data and recently updated clinical guidelines...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29643716/brain-metastasis-from-renal-urothelial-carcinoma-successfully-treated-by-metastasectomy
#11
Wen-Kuei Fang, Yeong-Chin Jou, Yuan-Chang Dai, Pi-Chan Ko, Ya-Fang Huang
Upper tract urothelial cancer (UTUC) arises from the urothelial lining of the urinary tract. UTUC spreads in several different ways including direct invasion, lymphatic spread, and hematogeneous metastases. Regional lymph nodes are commonly the initial site of metastasis, followed by the liver, lung, and bone. Brain metastasis is uncommon in patients with urothelial carcinoma. Here, we report an uncommon case of kidney urothelial carcinoma with brain metastasis in a 55-year-old woman presenting with dysarthria with right side limb weakness...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29599345/significance-of-perioperative-chemotherapy-in-squamous-cell-carcinoma-of-the-upper-and-lower-urinary-tract
#12
Tomoyuki Makino, Kouji Izumi, Ariunbold Natsagdorj, Hiroaki Iwamoto, Suguru Kadomoto, Renato Naito, Yoshifumi Kadono, Atsushi Mizokami
BACKGROUND/AIM: To evaluate the clinicopathological characteristics and prognosis of squamous cell carcinoma (SCC) of the urinary tract (UT) urothelium, and investigate the utility of perioperative chemotherapy. PATIENTS AND METHODS: Thirty-three patients diagnosed with SCC in renal pelvis, ureter and bladder at the Kanazawa University between 2007 and 2017 were included in this retrospective study. Cancer-specific survival (CSS) rates according to cancer stage and neoadjuvant chemotherapy (NAC) were determined...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29581871/positive-urinary-fluorescence-in-situ-hybridization-indicates-poor-prognosis-in-patients-with-upper-tract-urothelial-carcinoma
#13
Bao Guan, Yicong Du, Xiaohong Su, Zhenpeng Cao, Yifan Li, Yonghao Zhan, Ding Peng, Gengyan Xiong, Dong Fang, Yi Ding, Shiming He, Yanqing Gong, Qun He, Xuesong Li, Liqun Zhou
Here, we evaluated the potential contribution of fluorescent in situ hybridization (FISH) as a prognostic risk factor of bladder recurrence and survival in patients with upper tract urothelial carcinoma (UTUC). A total of 159 UTUC patients were enrolled in this study from January 2012 to May 2016. The 159 voided urine samples before surgery were analyzed using the UroVysion® kit to detect the copy numbers of chromosomes 3, 7, 17 and 9p21 (p16). Patients were classified using an optimal cutoff value of chromosomes 3, 7, 17, and 9p21...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29562765/comparison-of-flexible-ureterorenoscope-quality-of-vision-an-in-vitro-study
#14
Michele Talso, Silvia Proietti, Esteban Emiliani, Andrea Gallioli, Laurian Dragos, Andrea Orosa Andrada, Pol Servián, Aarón Barreiro, Guido Giusti, Emanuele Montanari, Bhaskar K Somani, Olivier Traxer
INTRODUCTION Flexible Ureterorenoscopy (fURS) is one of the best solution for treatment of renal calculi less than 2 cm and for upper tract urinary cancer (UTUC) conservative treatment. An adequate quality of vision is mandatory to help surgeon having better outcomes. No studies have been done, to our knowledge, about what fURS on the market has the best quality of vision. Material and Methods Seven different fURS were used to compare the image quality (Lithovue, OlympusV, OlympusV2, Storz FlexXC - in White Light and in ClaraChroma mode - , Wolf Cobra Vision, Olympus P6 and Storx Flex X2)...
March 21, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29551582/ki-67-as-a-prognostic-marker-in-upper-urinary-tract-urothelial-carcinoma-a-systematic-review-and-meta-analysis
#15
Chihyun Ahn, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Hyung Suk Kim, Ja Hyeon Ku
BACKGROUND: We systematically evaluated the prognostic significance of Ki-67 on survival outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). MATERIALS AND METHODS: We searched the Embase, Scopus, and PubMed databases for all articles published up to February 2017 by following the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. The outcomes of interest included intravesical recurrence (IVR)-free survival, disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS)...
February 24, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29538042/the-evolving-genomic-landscape-in-urothelial-cancer
#16
Lara Kujtan, Arif Hussain, Janakiraman Subramanian, Ashiq Masood
PURPOSE OF REVIEW: Recent advances in next-generation sequencing have allowed for detailed molecular analysis of urothelial carcinomas, with potentially significant clinical implications for personalized treatment. Our objective in this review is to highlight studies from the past year that have furthered the understanding of urothelial cancer genomics. RECENT FINDINGS: Recent studies by The Cancer Genome Atlas consortium further characterized urothelial carcinomas via molecular subtyping, and a schema was proposed to match each subtype with potential therapeutic implications...
May 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29534942/revisiting-the-prognostic-heterogeneity-of-ajcc-stage-iv-carcinomas-of-the-upper-urinary-tract
#17
Omar Abdel-Rahman
BACKGROUND: Current staging paradigms from the American Joint Committee on Cancer (AJCC) staging system for upper urinary tract carcinomas treat locoregionally advanced (T4 and N+) and metastatic (M1) patients as a single entity (stage IV). The current study proposes a modification of the AJCC staging system where these 2 entities are separated. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database (2004-2014) was accessed through SEER*Stat program...
February 22, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29534418/-application-of-narrow-band-imaging-flexible-ureteroscopy-in-the-diagnosis-treatment-and-follow-up-of-upper-tract-urothelial-carcinomas
#18
Y C Hao, C L Xiao, K Liu, Y Q Liu, L L Ma
Objective: To investigate application value of narrow-band imaging (NBI) flexible ureteroscopy in the diagnosis, treatment and follow-up of upper urinary tract transitional carcinomas (UTUC). Methods: From June 2015 to June 2017, 16 patients of UTUC were treated by flexible ureteroscopy with white light (WLI) and NBI at Department of Urology, Peking University Third Hospital , including 10 females and 6 males. The age of patients ranged from 43 to 84 years (average 68.9 years). There were 54 cases, including 16 cases with first-suspicion of cancer, and 38 cases with known of UTUC as follow-up...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29518027/expression-of-phospho-elk1-and-its-prognostic-significance-in-urothelial-carcinoma-of-the-upper-urinary-tract
#19
Satoshi Inoue, Hiroki Ide, Kazutoshi Fujita, Taichi Mizushima, Guiyang Jiang, Takashi Kawahara, Seiji Yamaguchi, Hiroaki Fushimi, Norio Nonomura, Hiroshi Miyamoto
Using preclinical models, we have recently found that ELK1, a transcriptional factor that activates downstream targets, including c-fos proto-oncogene, induces bladder cancer outgrowth. Here, we immunohistochemically determined the expression status of phospho-ELK1, an activated form of ELK1, in upper urinary tract urothelial carcinoma (UUTUC). Overall, phospho-ELK1 was positive in 47 (47.5%; 37 weak (1+) and 10 moderate (2+)) of 99 UUTUCs, which was significantly ( P = 0.002) higher than in benign urothelium (21 (25...
March 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29491095/expression-of-class-iii-beta-tubulin-predicts-prognosis-in-patients-with-cisplatin-resistant-bladder-cancer-receiving-paclitaxel-based-second-line-chemotherapy
#20
Yasuyoshi Miyata, Tomohiro Matsuo, Yuichiro Nakamura, Takuji Yasuda, Kojiro Ohba, Kosuke Takehara, Hideki Sakai
BACKGROUND/AIM: Class III beta-tubulin (TUBB3) expression is recognized as a predictive marker for chemosensitivity to cisplatin- and taxane-based chemotherapies in various malignancies. The aim of this study was to clarify the predictive value of TUBB3 expression for the anticancer effects of first-line cisplatin-based chemotherapy and second-line paclitaxel-based chemotherapy in patients with urothelial cancer (UC). PATIENTS AND METHODS: We reviewed 116 patients with UC (90 with bladder cancer and 27 with upper urinary tract cancer) treated with first-line cisplatin-based chemotherapy...
March 2018: Anticancer Research
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