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Upper Urinary Tract Cancer

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https://www.readbyqxmd.com/read/28216943/non-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-series-among-305-cases-at-a-tertiary-urology-institute
#1
Mohamed Mohamed Elawdy, Diaa-Eldin Taha, Yasser Osman, Mohamed Abd El-Hamid, Mohsen El-Mekresh
Non-transitional cell carcinomas (non-TCC) of the upper urinary tract as squamous cell carcinoma (SCC), adenocarcinoma, and small cell carcinoma (SmCC) are rare with few case reports in the literature. We retrospectively reviewed our patients who surgically treated for upper tract urothelial carcinoma from 1983 to 2013 for non-TCC pathological cancer characteristics and survival. Among 305 patients, only 5 (1.6%) cases were found: One case of SmCC, another had adenocarcinoma, and 3 SCC cases. None of them had intravesical recurrence and the cancer-specific survival for non-TCC cohort is markedly decreased (log-rank = 0...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28203133/simultaneously-diagnosed-and-successfully-treated-rectovaginal-and-vesicovaginal-fistulae-after-low-anterior-resection-with-concomitant-resection-of-female-genitalia
#2
Chisato Takagi, Hideo Baba, Kazuo Yamafuji, Atsunori Asami, Kaoru Takeshima, Nobuhiko Okamoto, Hidena Takahashi, Kiyoshi Kubochi
Rectovaginal fistula (RVF) and vesicovaginal fistula (VVF) are infrequent but distressing complications after pelvic surgery. However, their adequate treatment is not well described. Here, we simultaneously encountered and successfully treated RVF and VVF after radical surgery for rectal cancer. A 70-year-old woman underwent low anterior resection (LAR) combined with resection of the uterus, the bilateral adnexa, and the upper side of the vagina, as well as diverted ileostomy for rectal cancer. A month after the surgery, she developed urinary incontinence and underwent medical treatment, but her symptoms did not improve...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28174011/prognostic-role-of-neutrophil-to-lymphocyte-ratio-based-markers-during-pre-and-postadjuvant-chemotherapy-in-patients-with-advanced-urothelial-carcinoma-of-upper-urinary-tract
#3
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSE: The aim of the present study was to assess the prognostic significance of neutrophil-to-lymphocyte ratio (NLR)-based markers before and after adjuvant chemotherapy (ACH) in patients with urothelial carcinoma of the upper urinary tract (UTUC) undergoing radical nephroureterectomy (RNU) and ACH. MATERIALS AND METHODS: The data from 112 patients with advanced UTUC who had undergone first-line ACH after RNU from 1994 to 2012 were reviewed. After excluding 22 patients, the clinicopathologic data for 90 patients were analyzed, in particular, the NLR and derived NLR (dNLR) preoperatively and before and after ACH...
January 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28169459/long-term-effectiveness-and-complication-rates-of-bladder-augmentation-in-patients-with-neurogenic-bladder-dysfunction-a-systematic-review
#4
Lisette 't Hoen, Hazel Ecclestone, Bertil F M Blok, Gilles Karsenty, Véronique Phé, Romain Bossier, Jan Groen, David Castro-Diaz, Bárbara Padilla Fernández, Giulio Del Popolo, Stefania Musco, Jürgen Pannek, Thomas M Kessler, Tobias Gross, Marc P Schneider, Rizwan Hamid
AIMS: To systematically evaluate effectiveness and safety of bladder augmentation for adult neuro-urological patients. METHODS: The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement was followed for review of publications. The Medline, Embase, and Cochrane controlled trial databases and clinicaltrial.gov were searched until January 2015. No limitations were placed on date or language. Non-original articles, conference abstracts, and publications involving children and animals were excluded...
February 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28161840/long-term-outcomes-of-complete-urinary-tract-exenteration-for-dialysis-patients-with-urothelial-cancer
#5
Chien-Hui Ou, Wen-Horng Yang
PURPOSE: To survey long-term outcomes of dialysis patients with urothelial cancers who have undergone complete urinary tract exenteration (bilateral nephroureterectomy and cystectomy). METHODS: We retrospectively reviewed our patients with urinary tract urothelial cancer. Forty-two dialysis patients who underwent complete urinary tract exenteration were enrolled in our study. Seventeen patients had undergone one-stage complete urinary tract exenteration, and twenty-five patients had undergone multi-stage surgery...
February 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28152158/association-between-lymph-node-yield-and-survival-among-patients-undergoing-radical-nephroureterectomy-for-urothelial-carcinoma-of-the-upper-tract
#6
Piotr Zareba, Barak Rosenzweig, Andrew G Winer, Jonathan A Coleman
BACKGROUND: Prior studies examining the value of lymph node (LN) dissection (LND) in patients with urothelial carcinoma of the upper urinary tract (UTUC) have produced conflicting results. The objective of the current study was to assess the relationship between LN yield and survival among patients undergoing radical nephroureterectomy (RNU). METHODS: The National Cancer Data Base was used to identify patients with non-metastatic UTUC who were treated with RNU between 2004 and 2012...
February 2, 2017: Cancer
https://www.readbyqxmd.com/read/28117816/a-murine-orthotopic-bladder-tumor-model-and-tumor-detection-system
#7
Sin Mun Tham, Kesavan Esuvaranathan, Ratha Mahendran
This protocol describes the generation of bladder tumors in female C57BL/6J mice using the murine bladder cancer cell line MB49, which has been modified to secrete human Prostate Specific Antigen (PSA), and the procedure for the confirmation of tumor implantation. In brief, mice are anesthetized using injectable drugs and are made to lay in the dorsal position. Urine is vacated from the bladder and 50 µL of poly-L-lysine (PLL) is slowly instilled at a rate of 10 µL/20 s using a 24 G IV catheter. It is left in the bladder for 20 min by stoppering the catheter...
January 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28110834/preoperative-pyuria-is-a-poor-prognostic-factor-in-patients-with-urothelial-carcinoma-of-the-upper-urinary-tract-after-surgery
#8
Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Motohiko Sugi, Tadashi Matsuda
INTRODUCTION: The purpose of this study was to determine the prognostic significance of preoperative pyuria in patients with upper urinary tract urothelial carcinoma after surgery. PATIENTS AND METHODS: We retrospectively evaluated data on 157 patients with nonmetastatic upper urinary tract urothelial carcinoma who had undergone surgery at our institution. The associations between clinical features and advanced pathological findings were evaluated using a logistic regression model...
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28102436/-urethral-stricture-rate-after-prostate-cancer-radiotherapy-five-year-data-of-a-certified-prostate-cancer-center
#9
J Kranz, G Maurer, U Maurer, O Deserno, S Schulte, J Steffens
BACKGROUND: A urethral stricture is a scar of the urethral epithelium which can cause obstructive voiding dysfunction with consequential damage of the upper urinary tract. Almost 45% of all strictures are iatrogenic; they develop in 2-9% of patients after radical prostatectomy, but can also occur after prostate cancer radiotherapy. This study provides 5‑year data of a certified prostate cancer center (PKZ) in terms of urethral strictures. MATERIALS AND METHODS: Between 01/2008 and 12/2012 a total of 519 men were irradiated for prostate cancer (LDR and HDR brachytherapy as well as external beam radiation)...
January 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28078533/risk-factors-for-intravesical-recurrence-after-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#10
Ryo Yamashita, Reiko Watanabe, Ichiro Ito, Hideo Shinsaka, Masafumi Nakamura, Masato Matsuzaki, Masashi Niwakawa
PURPOSE: To determine major risk factors for bladder cancer (BC) recurrence after nephroureterectomy (Nux) by focusing on the pathologic appearances of tumors in upper urinary tract urothelial carcinomas (UUTUCs). METHODS: We performed 147 Nux procedures between November 2002 and September 2015. Forty-eight patients were excluded because of a history of BC (28 patients), previous or concurrent radical cystectomy (9 patients), neoadjuvant chemotherapy (5 patients), and other reasons (6 patients)...
January 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28065395/serial-retrograde-instillations-of-sustained-release-formulation-of-mitomycin-c-to-the-upper-urinary-tract-of-the-yorkshire-swine-using-a-thermosensitive-polymer-safety-and-feasibility
#11
Nicholas M Donin, Dalit Strauss-Ayali, Yael Agmon-Gerstein, Nadav Malchi, Andrew T Lenis, Stuart Holden, Allan J Pantuck, Arie S Belldegrun, Karim Chamie
BACKGROUND: MitoGel is a novel drug formulation intended for the treatment of upper tract urothelial cancer with proven feasibility and safety in an animal model. OBJECTIVE: To evaluate the feasibility, safety, toxicokinetics, and histologic changes associated with serial retrograde MitoGel instillations to the upper urinary tract in a swine model. DESIGN, SETTING, AND PARTICIPANTS: Overall, 27 Yorkshire swine underwent 6 once-weekly unilateral retrograde instillations of MitoGel...
January 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28052688/tert-promoter-mutation-status-in-sarcomatoid-urothelial-carcinomas-of-the-upper-urinary-tract
#12
Xiaoyan Wang, Antonio Lopez-Beltran, Adeboye O Osunkoya, Mingsheng Wang, Shaobo Zhang, Darrell D Davidson, Robert E Emerson, Sean R Williamson, Puay-Hoon Tan, Hristos Z Kaimakliotis, Lee Ann Baldridge, Gregory T MacLennan, Rodolfo Montironi, Liang Cheng
AIM: To determine TERT promoter mutation status as well as the expression of PAX8, GATA3, p63, p40, p53 and uroplakin III in 17 patients with the upper urinary tract sarcomatoid urothelial carcinoma. METHODS & RESULTS:  TERT C228T mutations were found in six of 17 cases (35%). p53 was expressed in 77% of these tumors. PAX8, GATA3, p40 and uroplakin III are less frequently expressed. Lymph node metastases were present in ten cases (59%). Eight patients (47%), including all three patients with TERT mutation, died of cancer within 2 years after surgery...
January 5, 2017: Future Oncology
https://www.readbyqxmd.com/read/28009144/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal
#13
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28006766/is-overexpression-of-ki-67-a-prognostic-biomarker-of-upper-tract-urinary-carcinoma-a-retrospective-cohort-study-and-meta-analysis
#14
Bo Fan, Hongshuo Zhang, Huidan Jin, Yu Gai, Honglong Wang, Huafeng Zong, Mingyu Jin, Hao Yang, Shuping Wan, Jiabin Zhu, Siyao Xu, Jianbo Wang, Deyong Yang, Xishuang Song
BACKGROUND: Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. The Ki-67 antigen is a classic marker of cellular proliferation, but there is still controversy regarding the significance and importance of Ki-67 in tumor progression. METHODS: In this study, we first detected Ki-67 expression in UTUC patients by immunohistochemistry (IHC). Subsequently, we quantitatively combined the results with those from the published literature in a meta-analysis after searching several databases...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27994654/downregulation-of-rnf128-predicts-progression-and-poor-prognosis-in-patients-with-urothelial-carcinoma-of-the-upper-tract-and-urinary-bladder
#15
Yi-Ying Lee, Chieh-Tien Wang, Steven Kuan-Hua Huang, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Chien-Feng Li
Background: The TP53 tumor suppressor gene plays a crucial role in the carcinogenesis of many malignancies, including urothelial carcinoma (UC). Overexpression of p53 is associated with poor prognosis in UC. Recently, RING finger protein 128 (RNF128) was shown to be involved in p53-induced apoptosis, forming a negative feedback loop. However, the significance of RNF128 in patients with UC remains unknown. In this study, our aim was to evaluate the expression of RNF128 in UC and to assess its predictive and prognostic value in a well-established cohort...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27936466/dpp4-cd26-overexpression-in-urothelial-carcinoma-confers-an-independent-prognostic-impact-and-correlates-with-intrinsic-biological-aggressiveness
#16
Peir-In Liang, Bi-Wen Yeh, Wei-Ming Li, Ti-Chun Chan, I-Wei Chang, Chun-Nung Huang, Ching-Chia Li, Hung-Lung Ke, Hsin-Chih Yeh, Wen-Jeng Wu, Chien-Feng Li
Urothelial carcinoma (UC) is common cancer worldwide. The molecular aberrations regarding tumor progression remain unclear. Pericellular proteolysis is crucial in tumorigenesis, but its significance is unexplored in UC. By data mining the datasets in Gene Expression Omnibus, specifically focus on the proteolysis pathway, and followed by a preliminary validation in a pilot batch of tumor samples, we identified that the upregulation of dipeptidyl peptidase 4 (DPP4) was most significantly associated with clinical aggressiveness of UCs...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27930897/percutaneous-nephrolithotomy-in-a-patient-with-mainz-pouch-ii-urinary-diversion-a-case-report
#17
Stavros Sfoungaristos, Ioannis Mykoniatis, Evangelos Poulios, Dimitrios Paikos, Dimitrios Hatzichristou
Mainz pouch II is a reliable and viable technique of continent urinary diversion. Patients are at increased risk of long-term complications including urolithiasis of the upper urinary tract and reservoir. We report the case of a 67-year-old male with prior Mainz pouch II due to invasive bladder cancer treated for a large renal calculus. Percutaneous nephrolithotomy (PCNL) was successfully performed. Stone management in these type of patients is of increased interest due to existed "anatomical challenges" concerning the access and safety during the procedure...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/27930581/associations-between-interventions-for-urolithiasis-and-urinary-tract-cancer-among-patients-in-taiwan-the-effect-of-early-intervention
#18
Chien-Liang Lin, Wen-Tsung Huang, Wen-Chou Fan, Yin-Hsun Feng, Chia-Ho Lin, Chian-Shiung Lin, Chih-Cheng Lu, Tse-Chou Cheng, Chao-Jung Tsao, Sheng-Hsiang Lin
The aim of this study was to investigate cancer risk in patients with a history of urolithiasis and to determine whether intervention for calculi attenuated the risk of subsequent urinary tract cancer (UTC).Using data from the National Health Insurance Research Database in Taiwan, we performed a nationwide cohort study enrolling participants (n = 42,732) aged > 30 years who were diagnosed with urinary tract calculi between 2000 and 2009. Age- and gender-matched insured individuals (n = 213,660) found in the health service records over the same period were recruited as the control group...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27878040/effect-of-contrast-media-on-urinary-cytopathology-specimens
#19
Sebastian Frees, Samir Bidnur, Michael Metcalfe, Peter Raven, Claudia Chavez-Munoz, Igor Moskalev, Ladan Fazli, Alan So
INTRODUCTION: Urological dogma dictates that washings collected from the urinary tract for cytological assessment must be performed without interference from contrast agents that may alter cellular integrity and diagnostic interpretation. In practice, the initial contrast used to outline the upper tracts is commonly discarded with subsequent saline washings sent for cytology. We hypothesize that contrast washings do not affect the morphology of urothelial carcinoma cells or the integrity of cytology interpretation...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27870887/epidermal-growth-factor-receptor-and-ki-67-as-predictive-biomarkers-identify-patients-who-will-be-more-sensitive-to-intravesical-instillations-for-the-prevention-of-bladder-cancer-recurrence-after-radical-nephroureterectomy
#20
Xingbo Long, Xiongbing Zu, Yuan Li, Wei He, Xiheng Hu, Shiyu Tong, Zhi Wang, Minfeng Chen, Lin Qi
BACKGROUND: To date, prophylactic intravesical chemotherapy after radical nephroureterectomy is one of the few available treatments that effectively prevent secondary bladder cancer. However, treating all patients with prophylactic intravesical chemotherapy is excessive for patients who are at a low risk or insensitive to the treatment. Thus, to guide individualized clinical treatment, in addition to identifying patients who are at risk of bladder cancer recurrence, it is equally necessary to identify the patients who will benefit the most from prophylactic, postoperative intravesical instillation therapy...
2016: PloS One
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