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https://www.readbyqxmd.com/read/29214871/rare-manifestations-of-extramedullary-myeloma-testicular-plasmacytomas
#1
Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Evaggelos Eleftherakis-Papaiakovou, Efstathios Kastritis, Evangelos Terpos, Meletios-Athanasios Dimopoulos
No abstract text is available yet for this article.
December 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29205163/extramedullary-plasmacytoma-of-the-testicle
#2
Diego M Carrion, Mario Álvarez-Maestro, Juan Gómez Rivas, Pilar González-Peramato, Jesús Cisneros Ledo
OBJECTIVE: We present the case of a patient diagnosed with a testicular extramedullary plasmacytoma (EMP), and perform a brief review of the literature of this pathology. METHODS: A 64 year-old male patient, with history of multiple myeloma successfully treated three years before, presented with left testicular swelling. Initial work-up was compatible with a testicular tumor and radical inguinal orchiectomy was performed. RESULTS: Histologic examination of the testis revealed extensive intertubular infiltration by CD138 and CD56 atypical plasma cells, with diffuse staining for IgA, compatible with EMP...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29204364/extramedullary-plasmacytoma-of-the-testis-a-case-report
#3
Kota Shimokihara, Takashi Kawahara, Sawako Chiba, Daiji Takamoto, Masahiro Yao, Hiroji Uemura
No abstract text is available yet for this article.
January 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29201298/lateralization-of-tibial-plateau-reference-point-improves-accuracy-of-tibial-resection-in-total-knee-arthroplasty-in-patients-with-proximal-tibia-vara
#4
Rajshekhar K Thippana, Malhar N Kumar
Background: The tibial cut referenced to the center of the intercondylar eminence often leads to varus malalignment in the presence of preexisting proximal tibia vara. The purpose of this study was to investigate the effect of lateralization of the lateral tibial plateau reference point (based on the amount of proximal tibia vara) on the postoperative coronal plane alignment. Methods: In this prospective cohort study, 62 patients (95 knees) with osteoarthritis and proximal tibia vara underwent primary total knee arthroplasty using a lateral tibial plateau reference point for the extramedullary jig...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29200701/a-rare-extramedullary-and-extralymphoid-presentation-of-mixed-phenotypic-blastic-hematolymphoid-neoplasm-a-study-of-two-cases
#5
Kiran Ghodke, Prashant Tembhare, Nikhil Patkar, P G Subramanian, Brijesh Arora, Sumeet Gujral
Mixed phenotype acute leukemia (MPAL) is a rare hematolymphoid neoplasm, representing only 3%-5% of acute leukemia. Although MPAL has been sufficiently described in the literature, its extramedullary presentation as a solitary lesion without leukemic (bone marrow [BM]) involvement is rarely described. We are presenting two cases of mixed phenotypic blastic hematolymphoid neoplasms without leukemic involvement at disease presentation in 8-year-old female and 21-year-old male patients. Both the cases had extralymphatic bone involvement in the form of solitary bone lesion...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29191538/collet-sicard-syndrome-attributable-to-extramedullary-plasmacytoma-of-the-jugular-foramen
#6
Soliman Oushy, Christopher S Graffeo, Avital Perry, Jonathan M Morris, Matthew L Carlson, Jamie J Van Gompel
BACKGROUND: Collet-Sicard syndrome is a rare manifestation of skull base disease involving the jugular and hypoglossal foramina. We report the first case of Collet-Sicard attributable to extramedullary plasmacytoma-multiple myeloma (EP-MM), as well as the second case of EP-MM precipitating a jugular foramen syndrome (JFS)-spectrum disorder. CASE DESCRIPTION: A fifty-nine-year-old woman presented with 4-months of left aural fullness and pulsatile tenderness, positional vertigo, hoarseness, and dysphagia...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29190822/the-tumor-suppressor-phosphatase-pp2a-b56%C3%AE-regulates-stemness-and-promotes-the-initiation-of-malignancies-in-a-novel-murine-model
#7
Mahnaz Janghorban, Ellen M Langer, Xiaoyan Wang, Derek Zachman, Colin J Daniel, Jody Hooper, William H Fleming, Anupriya Agarwal, Rosalie C Sears
Protein phosphatase 2A (PP2A) is a ubiquitously expressed Serine-Threonine phosphatase mediating 30-50% of protein phosphatase activity. PP2A functions as a heterotrimeric complex, with the B subunits directing target specificity to regulate the activity of many key pathways that control cellular phenotypes. PP2A-B56α has been shown to play a tumor suppressor role and to negatively control c-MYC stability and activity. Loss of B56α promotes cellular transformation, likely at least in part through its regulation of c-MYC...
2017: PloS One
https://www.readbyqxmd.com/read/29189509/successful-treatment-of-a-very-late-isolated-relapse-in-an-adolescent-with-a-picalm-mllt10-positive-t-lineage-acute-lymphoblastic-leukemia
#8
Emanuela Cannata, Piera Samperi, Carla Cimino, Silvia Marino, Federica Sullo, Elena Mirabile, Andrea Di Cataldo, Giovanna Russo, Luca Lo Nigro
T-lineage ALL is an aggressive disease that needs to be treated with intensive treatment schedules. A late relapse rarely occurs and a clear choice for second-line treatment is on debate. We report on a young adult with a very late isolated extramedullary relapse of PICALM-MLLT10 positive T-ALL, successfully treated with a chemotherapy-based and radiotherapy-based pediatric protocol. We demonstrate that relapse can occur in T-ALL although a SR-MRD behavior treated with a high-risk protocol; specific molecular diagnostic aberrations, as PICALM-MLLT10, are still conserved at very late relapse; a second-line treatment based on pediatric protocol can be effective...
November 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29175671/dietary-omega-3-and-omega-6-polyunsaturated-fatty-acids-modulate-hepatic-pathology
#9
Saraswoti Khadge, John Graham Sharp, Geoffrey M Thiele, Timothy R McGuire, Lynell W Klassen, Michael J Duryee, Holly C Britton, Alicia J Dafferner, Jordan Beck, Paul N Black, Concetta C DiRusso, James Talmadge
Recent evidence has suggested that dietary polyunsaturated fatty acids (PUFAs) modulate inflammation; however, few studies have focused on the pathobiology of PUFA using isocaloric and isolipidic diets and it is unclear if the associated pathologies are due to dietary PUFA composition, lipid metabolism or obesity, as most studies compare diets fed ad libitum. Our studies used isocaloric and isolipidic liquid diets (35% of calories from fat), with differing compositions of omega (ω)-6 or long chain (Lc) ω-3 PUFA that were pair-fed and assessed hepatic pathology, inflammation and lipid metabolism...
October 4, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29172311/case-report-metastatic-infratemporal-soft-tissue-myeloma-presenting-as-a-numb-lower-lip
#10
Niamh Rice, Badrinarayanan Srinivasan, David Macpherson
This is a case of a patient presenting to his general dental practitioner (GDP) with altered sensation in his lower lip with no obvious cause. Due to a prompt referral, the patient was investigated and diagnosed with an extramedullary presentation of multiple myeloma. A numb lip can present in general dental practice, although this is not common. There are several causes, for example, dental infection or fractured mandible. Clinical relevance: It is very important for the dental practitioner to recognize when there could be a potential sinister underlying cause and prompt referral, under the two week rule referral system, is indicated...
January 2017: Dental Update
https://www.readbyqxmd.com/read/29171634/-extramedullary-mediastinal-plasmacytoma-report-of-one-case
#11
Javier A Quilodrán, Camila Peña, Ximena Valladares
No abstract text is available yet for this article.
June 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29164520/adrenal-myelolipoma-a-comprehensive-review
#12
REVIEW
Ábel Decmann, Pál Perge, Miklós Tóth, Peter Igaz
INTRODUCTION: Adrenal myelolipoma is an invariably benign neoplasm of the adrenal gland that is the second most common primary adrenal incidentaloma following adrenocortical adenomas. It is composed of elements of adipose tissue and extramedullary hematopoiesis. Hypotheses on stem cells and hormonal factors have been formulated regarding its pathogenesis that is still obscure. Despite its benign behavior, adrenal myelolipoma is clinically relevant as it might cause significant difficulties in the differential diagnosis of adrenal tumors...
November 21, 2017: Endocrine
https://www.readbyqxmd.com/read/29163471/innate-b-1-b-cells-are-not-enriched-in-red-blood-cell-autoimmune-mice-importance-of-b-cell-receptor-transgenic-selection
#13
Amanda L Richards, Heather L Howie, Linda M Kapp, Jeanne E Hendrickson, James C Zimring, Krystalyn E Hudson
Autoimmune hemolytic anemia (AIHA) results from breakdown of humoral tolerance to RBC antigens. Past analyses of B-cell receptor transgenic (BCR-Tg) mice that recognize RBC autoantigens led to a paradigm in which autoreactive conventional B-2 B cells are deleted whereas extramedullary B-1 B cells escape deletion due to lack of exposure to RBCs. However, BCR-Tg mice utilized to shape the current paradigm were unable to undergo receptor editing or class-switching. Given the importance of receptor editing as mechanism to tolerize autoreactive B cells during central tolerance, we hypothesized that expansion of autoreactive B-1 B cells is a consequence of the inability of the autoreactive BCR to receptor edit...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29159157/surgical-removal-of-a-ruptured-radiculomedullary-artery-aneurysm-a-case-report
#14
Seung Bin Kim, Seung Pil Ban, Hyun-Jib Kim, O-Ki Kwon
Subarachnoid hemorrhage due to a solitary spinal aneurysm is extremely rare, and diagnosis and treatment are challenging. We report a rare case of a ruptured radiculomedullary artery aneurysm in a patient with Behçet disease. A 49-year-old man presented with severe lower abdominal and leg pain. Magnetic resonance imaging was performed and an enhanced intradural-extramedullary lesion at the T12 spinal level with subarachnoid hemorrhage was identified. Diagnostic spinal angiography was performed to evaluate the vascular lesion, and a radiculomedullary artery aneurysm at the T12 level was identified...
September 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29155065/intradural-extramedullary-cervical-cord-lipoma-case-report-and-literature-review
#15
Dimitrios Panagopoulos, Georgios Markogiannakis, Michael Koutzoglou
BACKGROUND: Spinal lipomas are generally thought to occur as a result of failed primary neurulation. Failed primary neurulation allows invasion of mesenchymal tissue of mesodermic origin into the neural structure, leading to the formation of a spinal lipoma. Despite most spinal lipomas being regarded as the result of failed primary neurulation, some confusion in terms of the embryogenesis of spinal lipomas remains. Recently, a novel classification of spinal lipomas based on embryonic changes seen during primary and secondary neurulation was has been proposed...
November 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29152275/isolated-myeloid-sarcoma-as-the-first-manifestation-of-acute-myeloid-leukemia-a-case-study
#16
Dorothy Mitkowski, Lidia Gil
This case report brings awareness to the diverse extramedullary manifestations of isolated myeloid sarcoma, as well as the importance and difficulties that are associated with establishing a rapid diagnosis and initiating treatment.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29147841/radiotherapy-for-extramedullary-leukaemic-manifestation-chloroma
#17
Michael Oertel, Khaled Elsayad, Uwe Haverkamp, Matthias Stelljes, Hans Theodor Eich
PURPOSE: Extramedullary leukaemic disease (EMD, synonym chloroma) is a rare solid manifestation of myeloid leukaemia for which the value of radiotherapy (RT) as a treatment strategy remains controversial. The aim of this study is to analyse the effectiveness of various RT doses for EMD in the modern treatment era. MATERIALS AND METHODS: Between January 2000 and June 2016, 20 patients with total of 45 lesions underwent RT for EMD at our institution. RESULTS: With a median radiation dose of 26 Gy (range 4-42 Gy), local remission could be achieved in 91% of patients (complete remission rate: 71%)...
November 16, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29145292/recurrent-spinal-primitive-neuroectodermal-tumor-with-brain-and-bone-metastases-a-case-report
#18
Frank Chen, Shyh-Shin Chiou, Sheng-Fung Lin, Ann-Shung Lieu, Yi-Ting Chen, Chih-Jen Huang
RATIONALE: Primary spinal primitive neuroectodermal tumor (PNET) is relatively rare in all age groups, and the prognosis in most cases of spinal PNETs appears to be poor, with a median patient survival of 1 to 2 years. We present a case with recurrent spinal PNET with brain and bone metastases that was successfully treated by multimodality treatment. PATIENT CONCERNS: A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144100/extramedullary-metastatic-plasmacytoma-in-a-multiple-myeloma-patient
#19
Alessandro Pileri, Elena Zamagni, Claudio Agostinelli, Paola Tacchetti, Miriam Leuzzi, Michele Cavo, Annalisa Patrizi
No abstract text is available yet for this article.
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29143958/intraspinal-mesenchymal-chondrosarcoma-report-of-a-pediatric-case-and-literature-review
#20
Angela Di Giannatale, Marta Colletti, Ida Russo, Valentina Ferruzzi, Vito Andrea Dell' Anna, Raffaele Cozza, Giovanna Stefania Colafati, Raffaella Messina, Angela Mastronuzzi, Rita De Vito, Giuseppe Maria Milano
PURPOSE: Mesenchymal chondrosarcoma (MCS) is an aggressive variant of chondrosarcoma and is a rare tumor, particularly within the pediatric population. Commonly, MCS originates in the bone, but it can also arise in extraskeletal sites, such as the brain and the intraspinal area. Due to the rarity of this tumor, there are no guidelines for its optimal treatment. METHODS: We report a case of intradural extramedullary MCS, located at the T11-T12 level, in a 14-year-old male...
November 15, 2017: Tumori
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