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Abhiraj D Bhimani, Ankit Indravadan Mehta
BACKGROUND: Intradural extramedullary (IDEM) spinal cord tumors account for two thirds of all intraspinal neoplasms. Surgery for IDEM tumors carries risk for many different complications, which to date have been poorly described and quantified. OBJECTIVE: To better characterize risk factors and complications for IDEM tumors, stratifying by spinal cord level and malignancy. METHODS: The ACS-NSQIP database was queried to determine 30-day outcomes following surgery for IDEM tumors between 2005 and 2016...
June 11, 2018: World Neurosurgery
Dezhi Li, Qian Liu, Zhifang Feng, Qi Zhang, Saran Feng
RATIONALE: Nephrogenic diabetes insipidus (NDI) rarely presents in the initial stage of acute lymphoblastic leukemia (ALL) and relapse due to renal infiltration is also rare. PATIENT CONCERNS: A 19-year-old man presented with weakness, polydipsia, and polyuria for 1 month. DIAGNOSES: NDI was diagnosed with insignificant response to a water deprivation test after stimulation with vasopressin injection. Bone marrow examination combined with immunophenotypic analysis, cerebrospinal cytology, and abdominal ultrasonography confirmed the diagnoses of precursor B cell ALL with renal infiltration...
June 2018: Medicine (Baltimore)
Leopoldo Luciano Luque, Maximo Marchetti, Daniel Seclen, Ariel Sainz, Marcelo Platas, Jorge Lambre
Neurenteric cysts (NC) are rare, benign, congenital lesions, caused by abnormal or persistent communications between neuroectodermal structures, the notochord and endodermal tissue. They present mainly in the pediatric population or young adults, coexisting with spinal, gastrointestinal or respiratory malformations. They are typically intradural extramedullary tumors, with intramedullary lesions the exception. The objective of this paper is to report the case of a cervical intramedullary neuroenteric cyst in a young adult, without coexisting malformations...
2018: Surgical Neurology International
Jagdish P Meena, Menka Yadav, Aditya K Gupta, Prashant Ramteke, Priyanka Naranje, Rachna Seth
Extramedullary leukemia is common in pediatric acute myeloid leukemia (AML) and occurs as a solid tumor (myeloid sarcoma). We report a case of a child who presented with acute onset of paraparesis and found to have intracranial and paravertebral mass; subsequently, he was diagnosed as having AML on tissue biopsy. He was started on AML treatment protocol, and later he was in remission and myeloid sarcoma got cleared from intracranial and paravertebral region. Timely diagnosis and initiation of treatment are essential to improve survival in such cases...
January 2018: Journal of Pediatric Neurosciences
Maria Gabelli, Marco Zecca, Chiara Messina, Elisa Carraro, Barbara Buldini, Attilio Maria Rovelli, Franca Fagioli, Alice Bertaina, Edoardo Lanino, Claudio Favre, Marco Rabusin, Arcangelo Prete, Mimmo Ripaldi, Walter Barberi, Fulvio Porta, Maurizio Caniglia, Stella Santarone, Paolo D'Angelo, Giuseppe Basso, Franco Locatelli
Relapse of acute lymphoblastic leukemia (ALL) may occur in extramedullary sites, mainly central nervous system (CNS) and testis. Optimal post-remissional treatment for isolated extramedullary relapse (IEMR) is still controversial. We collected data of children treated with hematopoietic stem cell transplantation (HSCT) for ALL IEMR from 1990 to 2015 in Italy. Among 281 patients, 167 had a relapse confined to CNS, 73 to testis, 14 to mediastinum, and 27 to other organs. Ninety-seven patients underwent autologous HSCT, 79 received allogeneic HSCT from a matched family donor, 75 from a matched unrelated donor, and 30 from an HLA-haploidentical donor...
June 13, 2018: Bone Marrow Transplantation
Christos Demosthenous, Chrysavgi Lalayanni, Michalis Iskas, Vassiliki Douka, Nikoleta Pastelli, Achilles Anagnostopoulos
Blinatumomab, a bispecific T-cell engager antibody construct targeting CD19, has been shown to improve the outcome in patients with relapsed and/or refractory B-cell acute lymphoblastic leukemia. Treatment with blinatumomab demonstrated significant survival benefit over chemotherapy, supporting its use as a bridge therapy to allogeneic hematopoietic stem cell transplantation. Unfortunately, following initial response, approximately 50% of responding patients eventually relapse. At the time of failure, the majority of patients have CD19-positive blasts, yet a concerning number of CD19-negative relapses has been reported...
May 7, 2018: Current Problems in Cancer
Naohisa Miyakoshi, Daisuke Kudo, Michio Hongo, Yuji Kasukawa, Yoshinori Ishikawa, Yoichi Shimada
BACKGROUND: Safe excision of spinal cord tumors depends on sufficient visualization of the tumor and surrounding structures. In patients with spinal cord tumor adjacent to a stenotic spinal canal, extensive bony decompression proximal and distal to the tumor should be considered for safer excision of the tumor. Extensive wide laminectomy is one choice for such cases, but postoperative problems such as kyphotic deformity remain a concern. CASE PRESENTATION: A 76-year-old man and a 60-year-old woman presented with symptomatic intradural extramedullary spinal cord tumors in the cervical spine...
June 11, 2018: BMC Surgery
Joana Ruivo Rodrigues, Manuel João Brito, Rui Pedro Faria Pais, Sílvia Carvalho
Myeloid sarcoma (MS), granulocytic sarcoma or chloroma, is defined as a localized extramedullary mass of blasts of granulocytic lineage with or without maturation, occurring outside the bone marrow. MS can be diagnosed concurrently with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The authors report a case of sacral MS occurring as a relapse of myeloid leukemia in a 5-year-old girl who was taken to the emergency department with radiculopathy symptoms.
2018: Case Reports in Radiology
Pablo Manresa Manresa, Eva María Arranz Oliva, Francisco José Illán Gambín, Francisco Javier Lucas Boronat
No abstract text is available yet for this article.
June 7, 2018: Medicina Clínica
Braden J Lawrence, Emily L Petersen, Wayne G Riches, David C Pfeiffer
Plasmacytomas are rare immunoproliferative monoclonal plasma cell diseases of lymphoid lineage that may present in an isolated or systemic manner. Systemic involvement is much more common than occurrences isolated to a particular organ, and for this reason, it is imperative to rule out systemic involvement for osseous and nonosseous isolated neoplasms. These neoplasms present unique challenges due to their location, extent of involvement, vague presentation, and dearth of treatment protocol. We report the case of a 69-year-old man who developed chronic kidney disease stage 4 between 2009 and 2012...
June 6, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Ming Yang, Matthew F Covington, Ba D Nguyen, Geoffrey B Johnson, Ruben A Mesa, Michael C Roarke
Objective: To define the role of combined Tc-99m sulfur colloid bone marrow (SC BM) scintigraphy, single-photon emission computed tomography (SPECT/CT), and chest CT in diagnosing diffuse pulmonary extramedullary hematopoiesis (PEMH) in patients with myelofibrosis (MF). Methods: We retrospectively reviewed Tc-99m SC BM scintigraphy scans performed at our institution for the diagnosis of diffuse PEMH, as well as accompanying chest CT and SPECT/CT imaging findings. Relevant clinical information, including respiratory manifestations, pulmonary hypertension (PH), and subjective response to whole-lung radiation therapy, was also summarized...
June 8, 2018: Journal of Nuclear Medicine Technology
Yusuke Noguchi, Daisuke Tomizawa, Haruka Hiroki, Satoshi Miyamoto, Mari Tezuka, Reiji Miyawaki, Mari Tanaka-Kubota, Tubasa Okano, Chika Kobayashi, Noriko Mitsuiki, Yuki Aoki, Kohsuke Imai, Michiko Kajiwara, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi
Myeloid/natural killer cell precursor acute leukemia (MNKPL) is a rare leukemia subtype characterized by a high incidence of extramedullary infiltration. No appropriate treatment strategy has so far been developed. Acute myelogenous leukemia-type chemotherapy combined with L-Asparaginase is an effective treatment for MNKPL. Hematopoietic cell transplantation is a second option in refractory cases.
June 2018: Clinical Case Reports
Simone E Dekker, Chad A Glenn, Thomas A Ostergard, Osmond C Wu, Fernando Alonso, Jonathan A Pace, Brian D Rothstein, Abhishek Ray, Nicholas C Bambakidis
This 3-dimensional operative video illustrates resection of 2 cervical spine schwannomas in a 19-yr-old female with neurofibromatosis type 2. The patient presented with lower extremity hyperreflexity and hypertonicity. Magnetic resonance imaging (MRI) demonstrated 2 contrast-enhancing intradural extramedullary cervical spine lesions causing spinal cord compression at C4 and C5. The patient underwent a posterior cervical laminoplasty with a midline dural opening for tumor resection. Curvilinear spine cord compression is demonstrated in the operative video...
June 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
Christopher Schiavo, Steven Alexander Mann, Jesse Mer, Attaya Suvannasankha
Testicular plasmacytomas are rare, accounting for only 1.3% of all extramedullary plasmacytomas. The infrequency in which it is encountered, coupled with its non-specific clinical and sonographic presentation, makes its diagnosis a challenge. We present a case of a 70-year-old man with multiple myeloma, which was systemically responding to chemotherapy, who developed testicular swelling, erythema and pain. Ultrasound findings were concerning for infection, although urine and serum testing were unremarkable...
June 4, 2018: BMJ Case Reports
Jonathan L Curry, Michael T Tetzlaff, Sa A Wang, Gene Landon, Nail Alouch, Sapna P Patel, Priyadharsini Nagarajan, Shiva Gupta, Phyu P Aung, Catherine E Devine, Joseph D Khoury, Sanam Loghavi, Victor G Prieto, Courtney D DiNardo, Jeffrey E Gershenwald
Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobiliary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies...
June 1, 2018: American Journal of Dermatopathology
Yan Xu, Wei Zhong, Minjiang Chen, Jing Zhao, Mengzhao Wang
Intradural extramedullary spinal cord metastases in lung cancer are rarely reported, but are a disastrous event because of severe clinical symptoms and poor prognosis. Herein, we report a case of a lung cancer patient with ALK rearrangement who experienced brain, leptomeningeal, and intradural extramedullary spinal cord metastases after developing resistance to crizotinib. After ceritinib therapy, his clinical symptoms improved and magnetic resonance imaging revealed that the intradural extramedullary lesions had reduced...
June 4, 2018: Thoracic Cancer
Sayed Shahabuddin Hoseini, Hongfen Guo, Zhihao Wu, Miho Nakajima Hatano, Nai-Kong V Cheung
Acute myeloid leukemia (AML), the most common acute leukemia in adults and the second most common cancer in children, is still a lethal disease in the majority of patients, but immunologic approaches have improved outcome. Bispecific antibodies (BsAbs) are novel immunotherapeutics that can redirect immune cells against AML. We now report a tetravalent (2+2) humanized BsAb in the immunoglobulin G light chain single chain fragment variable [IgG(L)-scFv] format to engage polyclonal T cells to kill CD33+ AML targets...
June 12, 2018: Blood Advances
Akihisa Oda, Toshiki Tezuka, Yuta Ueno, Shoko Hosoda, Yusuke Amemiya, Chihiro Notsu, Toru Kasahara, Chiharu Nishiyama, Ryo Goitsuka
Extramedullary hematopoiesis (EMH) in postnatal life is a pathological process in which the differentiation of hematopoietic stem/progenitor cells (HSPCs) occurs outside the bone marrow (BM) to respond to hematopoietic emergencies. The spleen is a major site for EMH; however, the cellular and molecular nature of the stromal cell components supporting HSPC maintenance, the niche for EMH in the spleen remain poorly understood compared to the growing understanding of the BM niche at the steady-state as well as in emergency hematopoiesis...
May 29, 2018: Scientific Reports
Saleh Al-Quraishy, Mohamed A Dkhil, E M Al-Shaebi, Abdel-Azeem S Abdel-Baki, Marcos J Araúzo-Bravo, Denis Delic, Frank Wunderlich
BACKGROUND: The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination-induced survival of blood-stage malaria. METHODS: Female Balb/c mice were vaccinated with a non-infectious vaccine consisting of plasma membranes isolated in the form of erythrocyte ghosts from P...
May 29, 2018: Malaria Journal
J Gregorová, D Vrábel, L Radová, N A Gablo, M Almaši, M Štork, O Slabý, L Pour, J Minařík, S Ševčíková
INTRODUCTION AND AIMS: Multiple myeloma (MM) is the second most common hematooncological disease. Patient survival has been greatly improved by the introduction of new drugs into clinical practice, but survival is negatively affected by the so-called extramedullary relapse (EM), caused by the loss of plasma cell dependence on the bone marrow microenvironment and their migration out of the bone marrow. The nature and causes of this process are currently unclear. MicroRNAs (miRNAs) are short, non-coding RNA molecules involved in many physiological and pathological processes...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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