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https://www.readbyqxmd.com/read/29035393/donor-lymphocyte-infusion-following-haploidentical-hematopoietic-cell-transplantation-with-peripheral-blood-stem-cell-grafts-and-ptcy
#1
S R Goldsmith, M Slade, J F DiPersio, P Westervelt, M A Schroeder, F Gao, R Romee
Donor-lymphocyte infusion (DLI) for relapse following haploidentical hematopoietic cell transplantation (haploHCT) with post-transplant cyclophosphamide (PTCy) has been described in recipients of bone marrow grafts, but not recipients of G-CSF mobilized peripheral blood (PB) grafts. We retrospectively identified patients who underwent DLI following PB-haploHCT with PTCy for relapse, or loss of chimerism (LOC). Twelve patients (57%) received DLI for hematologic relapse/persistent disease, seven (33%) for extramedullary relapse and two (10%) for LOC...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29033156/component-fracture-in-the-kotz-modular-femoral-tibial-reconstruction-system-an-under-reported-complication
#2
Tyler M Hauer, Matthew T Houdek, Rej Bhumbra, Anthony M Griffin, Jay S Wunder, Peter C Ferguson
BACKGROUND: Primary bone tumors of the femur are commonly reconstructed using an endoprosthesis. Different modes of implant failure have been described, including structural failure; although uncommon, this may be an under-reported complication. The purpose of this study is to examine the rates and risk factors for implant fracture of the Kotz Modular Femoral Tibial Reconstruction system (KMFTR). METHODS: Two hundred twenty-one patients (95 women and 126 men) who underwent a KMFTR reconstruction were reviewed...
September 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29027893/hospital-acquired-conditions-predictors-and-implications-for-outcomes-following-spine-tumor-resection
#3
Nikita Lakomkin, Constantinos G Hadjipanayis
OBJECTIVE Hospital-acquired conditions (HACs) significantly compromise patient safety, and have been identified by the Centers for Medicare and Medicaid Services as events that will be associated with penalties for surgeons. The mitigation of HACs must be an important consideration during the postoperative management of patients undergoing spine tumor resection. The purpose of this study was to identify the risk factors for HACs and to characterize the relationship between HACs and other postoperative adverse events following spine tumor resection...
October 13, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29026667/lumbar-chronic-subdural-hematoma-mimicking-an-intradural-extramedullary-tumor-a-case-report
#4
Hyeun Sung Kim, Nitin Adsul, Yoon Seok Ju, Ki Joon Kim, Sung Ho Choi, Jeong Hoon Kim, Sung Kyun Chung, Jeong-Hoon Choi, Jee-Soo Jang, Il-Tae Jang, Seong-Hoon Oh, Jae Eun Park, Sol Lee
BACKGROUND: Chronic spinal subdural hematomas are extremely rare with only 28 cases reported in the literature. Nevertheless, they should be considered among the differential diagnoses for spinal intradural/extramedullary lesions. CASE REPORT: A 65-year-old male presented with progressive back pain and right S1 radiculopathy. Magnetic resonance imaging scan revealed a right-sided posterolateral intradural/extramedullary lesion at the L5-S1 level. It was hyperintense on T1 and hypointense on T2-weighted images; on the short TI inversion recovery sequence it was hyperintense...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29024842/peritoneal-carcinomatosis-like-implants-of-extramedullary-hematopoiesis-an-insolite-occurrence-during-splenectomy-for-myelofibrosis
#5
Marco Casaccia, Rosario Fornaro, Marco Frascio, Denise Palombo, Cesare Stabilini, Emma Firpo, Ezio Gianetta
INTRODUCTION: Primary myelofibrosis (MF) is a myeloproliferative neoplasm that results in debilitating constitutional symptoms, splenomegaly, and cytopenias. In patients with symptomatic splenomegaly, splenectomy remains a viable treatment option for MF patients with medically refractory symptomatic splenomegaly that precludes the use of ruxolitinib. CASE PRESENTATION: We present the clinical case of a patient who was admitted to our Department to perform a splenectomy in MF as a therapeutic step prior to an allogeneic stem cell transplantation (ASCT)...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29021984/mri-findings-of-early-stage-hyperacute-hemorrhage-causing-extramedullary-compression-of-the-cervical-spinal-cord-in-a-dog-with-suspected-steroid-responsive-meningitis-arteritis
#6
Adriano Wang-Leandro, Enrice-Ina Huenerfauth, Katharina Heissl, Andrea Tipold
A 9-month-old female Weimaraner was presented to the emergency service due to episodes of fever and neck pain. Physical examination revealed a stiff neck posture and elevated body temperature. Shortly after clinical examination was performed, the dog developed peracute onset of non-ambulatory tetraparesis compatible with a C1-C5 spinal cord (SC) lesion. Immediately thereafter (<1 h), MRI of the cervical SC was performed with a 3-T scanner. A left ventrolateral intradural-extramedullary SC compression caused by a round-shaped structure at the level of C3--C4 was evidenced...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29021476/a-rare-monocytic-crisis-of-chronic-myelogenous-leukemia-presenting-with-unusual-extramedullary-manifestations-and-an-atypical-14-22-q24-q11-2-translocation-in-the-bone-marrow
#7
Morihiro Inoue, Masao Hagihara, Tomoyuki Uchida, Jian Hua, Takeshi Nakajima, Shogo Tajima, Yasunori Ota
A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29019745/imaging-of-nonmalignant-adrenal-lesions-in-children
#8
Kiran M Sargar, Geetika Khanna, Rebecca Hulett Bowling
The adrenal glands in children can be affected by a variety of benign lesions. The diagnosis of adrenal lesions can be challenging, but assessment of morphologic changes in correlation with the clinical presentation can lead to an accurate diagnosis. These lesions can be classified by their cause: congenital (eg, discoid adrenal gland, horseshoe adrenal gland, and epithelial cysts), vascular and/or traumatic (eg, adrenal hemorrhage), infectious (eg, granulomatous diseases), enzyme deficiency disorders (eg, congenital adrenal hyperplasia [CAH] and Wolman disease), benign neoplasms (eg, pheochromocytomas, ganglioneuromas, adrenal adenomas, and myelolipomas), and adrenal mass mimics (eg, extralobar sequestration and extramedullary hematopoiesis)...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28993357/runx1-runx1t1-positive-acute-myeloid-leukaemia-presenting-as-bilateral-proptosis-and-multiple-cranial-nerve-palsy
#9
Sidharth Totadri, Prateek Bhatia, Sreejesh Sreedharanunni
We describe a unique presentation of acute myeloid leukaemia (AML) with myeloid sarcoma (MS), manifested as proptosis with multiple cranial nerve palsies in a 9-year-old boy. MRI of the brain revealed multiple enhancing lesions and bilateral mastoiditis, in addition to sagittal sinus thrombosis. Peripheral blood smear demonstrated blasts showing Auer rods. Bone marrow examination confirmed the diagnosis of AML. PCR was positive for RUNX1-RUNX1T1. Neurological deficits improved with induction chemotherapy for AML...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28991134/isolated-testicular-recurrence-of-aml-in-patients-with-chronic-gvhd-1-year-following-allogeneic-stem-cell-transplant
#10
Brian N Dang, Satiro De Oliveira, LaVette Bowles, Theodore B Moore
BACKGROUND: Patients with chronic graft-versus-host disease (cGVHD) following allogeneic transplant for myeloid leukemias seem to experience a reduced risk of relapse than comparable patients without cGVHD. It is unclear to what extent extramedullary sites are impacted by a graft-versus-leukemia effect. DESIGN/METHOD: Case Series and review of the literature. RESULTS: We present 2 cases of pediatric patients with Acute Myelogenous Leukemia who developed isolated testicular relapse more than a year following hematopoietic stem cell transplantation despite having had extensive cGVHD...
October 4, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28983055/pattern-of-somatic-mutations-in-patients-with-waldenstr%C3%A3-m-macroglobulinemia-or-igm-monoclonal-gammopathy-of-undetermined-significance
#11
Marzia Varettoni, Silvia Zibellini, Irene Defrancesco, Virginia Valeria Ferretti, Ettore Rizzo, Luca Malcovati, Anna Gallì, Matteo Giovanni Della Porta, Emanuela Boveri, Luca Arcaini, Chiara Candido, Marco Paulli, Mario Cazzola
We analyzed MYD88 and CXCR4 mutation status of 260 patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance using allele-specific real time quantitative PCR and Sanger sequencing respectively. A subgroup of 119 patients was further studied with next-generation sequencing of 11 target genes (MYD88, CXCR4, ARID1-A, KMT2D, NOTCH2, TP53, PRDM1, CD79B, TRAF3, MYBBP1A, TNFAIP3). MYD88 (L265P) was found at diagnosis in 91% of patients with Waldenström macroglobulinemia and in 60% of patients with IgM monoclonal gammopathy of undetermined significance using allele-specific PCR...
October 5, 2017: Haematologica
https://www.readbyqxmd.com/read/28976901/a-technical-problem-in-diagnosis-clarity-of-solitary-spinal-cord-neurofibroma-in-an-eleven-month-old-boy
#12
Elena G Poriazova, Oliana B Boykinova, Ivan S Ivanov, Maria I Spasova, Georgi B Bozhilov, Ani K Kevorkyan, Stoyan S Novakov
Spinal neurofibroma is one of the rarest of the neoplasms involving the spinal cord or roots and occurs much less often than neurinoma, meningioma or glioma. The sixth pediatric case of solitary intramedullary tumor was described in 2013, according to B. Eljebbouri et al. We present a rare, difficult to diagnose and may-be the seventh pediatric case of solitary neurofibroma of the cauda equine in an 11-month-old infant. The patient underwent a laminectomy of T12, L1, L2 and L3, extirpation of intradural, intramedullary and extramedullary spinal cord tumor...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28975064/neuroleukemiosis-two-case-reports
#13
Vlad Voin, Shehzad Khalid, Sebastian Shrager, R Shane Tubbs, Robert Greiner, Krishnamoorthy Thamburaj, Elias Rizk
Extramedullary tumors composed of myeloblasts or monoblasts can present in various locations. Patients with a history of acute myeloid leukemia (AML) can present with neuropathic pain and no evidence of relapse of their leukemia. Neuroleukemiosis is a form of extramedullary tumor present in the peripheral nervous systems (PNS) of leukemia patients. We report two AML patients who were in remission and later presented with neurological symptoms due to neuroleukemiosis with negative bone marrow biopsies.
July 31, 2017: Curēus
https://www.readbyqxmd.com/read/28974413/intradural-spinal-tumors-a-review-of-post-operative-outcomes-comparing-intramedullary-and-extramedullary-tumors-from-a-single-institution-s-experience
#14
Z X Ng, S Ng, V Nga, K J Teo, S Lwin, C Ning, T T Yeo
Intradural spinal tumors are rare and can be classified into extramedullary or intramedullary. They commonly present with symptoms such as intractable back pain or neurological deficits. We retrospectively reviewed 91 cases of intradural spinal tumors that underwent surgery in our institution from 2011 to 2016 and their assessed clinical outcomes. The majority of intradural tumors were extramedullary (89%) and the most common pathology was schwanommas (38.5%) followed by meningiomas (29.7%). Comparing extramedullary vs...
September 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28972947/the-peritoneum-health-disease-and-perspectives-regarding-tissue-engineering-and-cell-therapies
#15
Ronaldo J F C do Amaral, Kátia D Arcanjo, Márcia C El-Cheikh, Felipe L de Oliveira
There are several pathologies associated with the peritoneum, such as mesothelioma and peritonitis. Moreover, the peritoneum is widely used in ultrafiltration procedures, i.e., peritoneal dialysis, presenting advantages over hemodialysis. On the other hand, ultrafiltration failure may lead to dialysis-induced fibrosis and hypervolemia. Therefore, the pathophysiological study of this tissue is of extreme biomedical importance. Studies investigating the biology of the cells dwelling in the peritoneum wall provide evidence of their plasticity and progenitor features...
October 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28971002/pulmonary-myelolipoma-containing-osseous-tissue-an-unexpected-finding-at-autopsy
#16
Silvija Mašić, Majda Vučić, Sven Seiwerth
Pulmonary myelolipoma is a very rare benign tumor composed of mature adipose tissue and hematopoietic elements such as erythroid, myeloid and megakaryocytic. It usually represents accidental finding during autopsy or chest imaging, since most cases are asymptomatic. Larger masses can lead to hemorrhage, chest pain and chest organ compression. We present a case of incidental finding of pulmonary myelolipoma during the autopsy of an 83- year old woman who died of abdominal aortic rupture. In the right lower lung lobe, solitary, well-circumscribed yellow-brown nodule which was 3 cm in its longest diameter was found...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28963446/clinical-features-of-multiple-myeloma-patients-with-isolated-extramedullary-relapse
#17
Xiao-Yan Qu, Li-Juan Chen, Tian Tian, Li-Min Duan, Rui-Nan Lu, Hua Lu, Han-Xin Wu, Jian-Yong Li
This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression. The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients. These patients had secretory multiple myeloma at diagnosis. When relapsed, the dissociation between medullary and extramedullary response was detected. The serum or urine monoclonal component was extremely low or absent. The plasma cells in bone marrow were<5%...
September 30, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28962027/intraoperative-spinal-navigation-for-the-removal-of-intradural-tumors-technical-notes
#18
Roberto Stefini, Stefano Peron, Jaime Mandelli, Elena Bianchini, Paolo Roccucci
BACKGROUND: In recent years, spinal surgery has incorporated the many advantages of navigation techniques to facilitate the placement of pedicle screws during osteosynthesis, mainly for degenerative diseases. However, spinal intradural tumors are not clearly visible by intraoperative fluoroscopy or computed tomography scans, thereby making navigation necessary. OBJECTIVE: To evaluate the use of spinal navigation for the removal of intradural and spinal cord tumors using spinal magnetic resonance imaging (MRI) merged with intraoperative 3-dimensional (3-D) fluoro images...
August 5, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28958166/igg4-related-disease-presenting-as-intradural-extramedullary-lesion-a-case-report-and-review-of-the-literature
#19
Kelly J Bridges, Caitlin H DeDeaux, Khoi D Than
OBJECT: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder affecting various anatomical sites, and only recently was identified to affect the dura of the spine. The authors present the second reported case of an intradural extramedullary lesion consistent with IgG4-related spinal disease. METHODS: A literature review was performed that identified 15 other cases of spinal disease, and common features of all known reported spinal IgG4-RD are discussed...
September 28, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28958136/cyberknife%C3%A2-system-a-new-therapeutic-strategy-for-sinonasal-solitary-extramedullary-plasmacytomae
#20
E Cantone, V Borzillo, A M Di Lullo, L Marano, E Guadagno, G Mansueto, R Di Franco, F Cammarota, L Catalano, P Muto, M Iengo
Sino-nasal solitary extramedullary plasmacytoma (EMP) is a rare neoplasm with unpredictable progression to multiple myeloma. To improve the precision of irradiation delivery, preserving the healthy surrounding tissue and critical structures we used a CyberKnife® for the treatment of sinonasal solitary extramedullary plasmacytoma. We present the first case of sinonasal-EMP treated with CyberKnife®-stereotactic radiotherapy (SRT) with a complete remission without adverse events. Based on the post-therapeutic results and healthy tissue preservation, we believe that CyberKnife®-SRT represents a good therapeutic option for the treatment of sinonasal-EMP...
July 2017: Journal of Biological Regulators and Homeostatic Agents
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