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https://www.readbyqxmd.com/read/29667156/how-we-manage-patients-with-plasmacytomas
#1
REVIEW
Despina Fotiou, Meletios A Dimopoulos, Efstathios Kastritis
PURPOSE OF REVIEW: To discuss the diagnostic approach, treatment options, and future considerations in the management of plasmacytomas, either solitary or in the context of overt multiple myeloma (MM). RECENT FINDINGS: Advanced imaging techniques such as whole-body magnetic resonance imaging and positron emission tomography/computerized tomography are essential for the diagnostic workup of solitary plasmacytomas (SP) to rule out the presence of other disease foci...
April 17, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29662860/splenic-myeloid-metaplasia-in-warm-autoimmune-hemolytic-anemia-waiha-a-retrospective-study
#2
Víctor Manuel Anguiano-Álvarez, Alonso Hernández-Company, Nashla Hamdan-Pérez, Daniel Montante-M, Diego A Zúñiga-Tamayo, Sergio Rodríguez-Rodríguez, Alan Pomerantz, Elena J Tuna-Aguilar
Background: Splenic myeloid metaplasia (SMM) is a kind of extramedullary hematopoiesis, whereas its clinical significance in wAIHA remains unclear. The aim of this study is evaluating the frequency and clinical characteristics of SMM, compared with splenic-congestion (SC). Methods: We included patients with wAIHA treated in a Mexican tertiary hospital between January 1992 and December 2015. All patients received steroids as first-line treatment and splenectomy as second-line treatment...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29650946/a-rare-case-of-relapsed-pediatric-acute-promyelocytic-leukemia-with-skin-involvement-by-myeloid-sarcoma
#3
Nathalia Silva Araújo, Claudio José Dos Santos Júnior, Vitória Mikaelly da Silva Gomes, Luiz Arthur Calheiros Leite, Luana Novaes Bomfim, Amanda Katielly Firmino da Silva Gusmão, Maria Jordana Rocha Gomes Alves, Cyndi Myrelle da Silva Barros Romão, Arthur Moacir Costa Sampaio Batinga, Maria Rosa da Silva, Célio Fernando de Sousa Rodrigues
BACKGROUND Acute promyelocytic leukemia (APL) is a very rare leukemia in children. Extramedullary involvement by APL has been reported in between 3-5% of cases, mainly associated with cases of relapse. A rare case of relapse of APL in a 9-year-old child is presented with skin involvement with myeloid sarcoma. CASE REPORT A 9-year-old male child was admitted to the Oncology Service of the hospital complaining of fever, progressive fatigue, oral petechiae with severe bleeding in the oral cavity. Bone marrow examination showed some promyelocytes...
April 13, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29649676/intradural-spinal-tumors-10-years-surgical-experience-in-a-single-institution
#4
Pablo David Guerrero-Suarez, Ernesto Magdaleno-Estrella, Paola Guerrero-López, Arturo Isaac Vargas-Figueroa, Jaime Jesús Martínez-Anda
OBJECTIVES: The aim of the study is to present the therapeutic results of intradural tumor management over a 10 years period in a single institution. PATIENTS AND METHODS: The study consists in a prospective case series of patients treated at the neurosurgery service of the Social Security Institute of Mexico State and Provinces (ISSSEMYM), between January 2006 and December 2016. All patients were provided with information about the procedure and signed informed consent and institutional board approved files review for this study...
March 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29628719/extramedullary-haematopoiesis-an-unusual-etiology-of-backache
#5
Ankur Jain, Praveen Sharma, Alka Khadwal, Pankaj Malhotra
No abstract text is available yet for this article.
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29619633/primary-extramedullary-plasmacytoma-of-the-sigmoid-colon-with-perforation-a-case-report
#6
Fumimasa Kitamura, Koichi Doi, Hiroyuki Ishiodori, Tetsufumi Ohchi, Hideo Baba
BACKGROUND: Extramedullary plasmacytomas account for 4% of all plasma cell tumors and occur mainly in the upper respiratory tract; gastrointestinal system involvement is rare. Extramedullary plasmacytoma of the colon with perforation has not been reported. CASE PRESENTATION: A 77-year-old woman with a 1-year history of lower abdominal pain and nausea was admitted to our hospital. An abdominal computed tomography scan revealed a sigmoid tumor with perforation. The patient underwent emergency surgery...
April 4, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29619260/bilateral-conjunctival-infiltration-as-an-extramedullary-relapse-of-aml
#7
Zahra Mozaheb, Alireza Khooei
Acute myelogenous leukemia (AML) accounts for 1.2% of all cancer deaths. Relapse is the major cause of treatment failure in acute myeloid leukemia (AML) patients. AML rarely presents as ocular manifestation in relapse or at presentation. The M4 subtype of AML is most commonly presented with extramedullary involvement. In this report, we presented a young female with AML who was diagnosed and treated for AML about 40 months ago. She did not transplant because she did not have a full-match donor. About 4 months ago, she visited with a red eye and conjunctival infiltration...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29613896/neoplastic-myelopathies
#8
Jing Wu, Surabhi Ranjan
PURPOSE OF REVIEW: This article discusses the diagnosis and management of neoplasms that affect the spinal cord as well as spinal cord disorders that can occur due to cancer treatments. RECENT FINDINGS: Neoplastic myelopathies are uncommon neurologic disorders but cause significant morbidity when they occur. Primary spinal cord tumors can be classified into intramedullary, intradural extramedullary, or extradural tumors. Diffuse gliomas and ependymal tumors are the most common intramedullary tumors...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29610955/prognostic-value-of-18-f-fdg-pet-ct-in-multiple-myeloma-patients-before-and-after-allogeneic-hematopoietic-cell-transplantation
#9
Antje Stolzenburg, Katharina Lückerath, Samuel Samnick, Martin Speer, Katharina Kneer, Jan-Stefan Schmid, Götz Ulrich Grigoleit, Susanne Hofmann, Ambros J Beer, Donald Bunjes, Stefan Knop, Andreas K Buck, Hermann Einsele, Constantin Lapa
PURPOSE: Despite improved treatment options, multiple myeloma (MM) remains an incurable disease. The aim of this study was to investigate the prognostic value of positron emission tomography/computed tomography (PET/CT) using18 F-2'-deoxy-2'-fluorodeoxyglucose ([18 F]FDG) in MM patients shortly before and ~100 days after allogeneic hematopoietic cell transplantation (allo-HCT). METHODS: In this retrospective analysis, we evaluated [18 F]FDG-PET/CT-scans of 45 heavily pre-treated MM patients before and 27 patients after scheduled allo-HCT...
April 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29603773/treatment-patterns-and-clinical-outcomes-in-high-risk-newly-diagnosed-multiple-myeloma-patients-carrying-the-17p-deletion-an-observational-multi-center-retrospective-study
#10
Yael C Cohen, Avi Saranga, Moshe E Gatt, Noa Lavi, Chezi Ganzel, Hila Magen, Irit Avivi, Tamar Tadmor, Celia Suriu, Osnat Jarchowsky Dolberg, Amitai Papushado, Svetlana Trestman, Ron Ram
Del17p is a genomic imbalance occurring in ∼7-10% of myeloma at diagnosis (NDMM) and comprises a poor prognostic factor. The goal of this study is to analyze real world data and outcomes among NDMM patients carrying 17p deletion. We report an observational, retrospective, multicenter study. Sixty consecutive patients diagnosed with multiple myeloma in the 8 participating centers diagnosed between 1/2008-1/2016 proven to carry 17p deletion by means of FISH were identified. Most received a bortezomib-based induction, over half underwent autologous hematopoietic cell transplantation (HCT); 30% of the patients gained early access to new novel agents via clinical trials, access programs or private insurance...
March 31, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29602699/intramedullary-versus-extramedullary-internal-fixation-for-unstable-intertrochanteric-fracture-a-meta-analysis
#11
Xi Yu, Hong Wang, Xin Duan, Ming Liu, Zhou Xiang
OBJECTIVE: The aim of this meta-analysis was to explore the difference between and compare intramedullary fixation (IF) and extramedullary fixation (EF) for unstable intertrochanteric fractures. METHODS: We searched Pubmed database and Cochrane library following by including and excluding articles based from inception to December, 2016. All randomized controlled trials (RCTs) comparing IF and EF for unstable intertrochanteric fractures were assessed and selected by two researchers independently...
March 27, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29602174/expression-of-programmed-death-ligand-1-is-associated-with-poor-prognosis-in-myeloid-sarcoma-patients
#12
Keisuke Kawamoto, Hiroaki Miyoshi, Takaharu Suzuki, Junichi Kiyasu, Shintaro Yokoyama, Yuya Sasaki, Hirohito Sone, Masao Seto, Jun Takizawa, Koichi Ohshima
Myeloid sarcoma (MS) is a rare condition and is an extramedullary tumour of immature myeloid cells. It is now known that the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway suppresses the host antitumor responses and that these products are expressed on both tumour cells and tumour-infiltrating cells in various malignancies. However, little is known about the significance of PD-1/PD-L1 expression on tumour cells and tumour microenvironmental cells in MS. To investigate the clinicopathological significance of PD-1/PD-L1 expression in MS, we analyzed 98 patients by immunohistochemistry...
March 30, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29588374/flow-cytometric-minimal-residual-disease-assessment-of-peripheral-blood-in-acute-lymphoblastic-leukaemia-patients-has-potential-for-early-detection-of-relapsed-extramedullary-disease
#13
Alissa Keegan, Karry Charest, Ryan Schmidt, Debra Briggs, Daniel J Deangelo, Betty Li, Elizabeth A Morgan, Olga Pozdnyakova
OBJECTIVES: To evaluate peripheral blood (PB) for minimal residual disease (MRD) assessment in adults with acute lymphoblastic leukaemia (ALL). METHODS: We analysed 76 matched bone marrow (BM) aspirate and PB specimens independently for the presence of ALL MRD by six-colour flow cytometry (FC). RESULTS: The overall rate of BM MRD-positivity was 24% (18/76) and PB was also MRD-positive in 22% (4/18) of BM-positive cases. We identified two cases with evidence of leukaemic cells in PB at the time of the extramedullary relapse that were interpreted as MRD-negative in BM...
March 27, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29584909/spinal-stenosis-secondary-to-extramedullary-hematopoeisis-in-beta-thalassaemia
#14
Li Liang Joshua Lim, Ling Ling Chan
No abstract text is available yet for this article.
March 23, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29582697/nonhepatosplenic-extramedullary-manifestations-of-chronic-myelomonocytic-leukemia-clinical-molecular-and-prognostic-correlates
#15
Katherine Hoversten, Rangit Vallapureddy, Terra Lasho, Christy Finke, Rhett Ketterling, Curtis Hanson, Naseema Gangat, Ayalew Tefferi, Mrinal M Patnaik
No abstract text is available yet for this article.
March 27, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29581891/multifocal-primary-melanoma-of-the-cervical-spinal-cord-successfully-treated-by-tumorectomy-a-case-report
#16
Takahito Iga, Akio Iwanami, Takeru Funakoshi, Shuji Mikami, Osahiko Tsuji, Narihito Nagoshi, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Kota Watanabe, Masaya Nakamura, Morio Matsumoto
Introduction: Multifocal primary melanoma of the spine is extremely rare. Here, we report a case of multifocal primary melanoma of the cervical spinal cord. Case presentation: A 39-year-old man presented with a 1-year history of numbness of the upper extremities and back. Magnetic resonance imaging of the cervical spine suggested multifocal intradural extramedullary tumors at levels C2 and C4-C5. A diagnostic biopsy revealed a pathological diagnosis of malignant melanoma...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29576643/total-knee-arthroplasty-using-patient-specific-blocks-after-prior-femoral-fracture-without-hardware-removal
#17
Raju Vaishya, Vipul Vijay, Amit K Agarwal
Background: The options to perform total knee arthroplasty (TKA) with retained hardware in femur are mainly - removal of hardware, use of extramedullary guide, or computer-assisted surgery. Patient-specific blocks (PSBs) have been introduced with many potential advantages, but their use in retained hardware has not been adequately explored. The purpose of the present study was to outline and assess the usefulness of the PSBs in performing TKA in patients with retained femoral hardware...
March 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29573918/minimum-10-year-outcome-of-one-stage-total-hip-arthroplasty-without-subtrochanteric-osteotomy-using-a-cementless-custom-stem-for-crowe-iii-and-iv-hip-dislocation
#18
Olivier Freddy Hitz, Xavier Flecher, Sébastien Parratte, Matthieu Ollivier, Jean-Noël Argenson
BACKGROUND: Options for total hip arthroplasty (THA) in high dislocated hips include subtrochanteric osteotomy (STO), high hip center positioning, and 2-stage surgery with progressive lowering using an external fixator before THA. We described the long-term results of 1-stage THA performed without STO, using a cementless customized stem associated if necessary with sequential tenotomies and/or greater trochanteric osteotomy. METHODS: Ninety-eight consecutive THA without STO were performed using this technique...
February 21, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29567900/anastomosing-hemangioma-with-extensive-fatty-stroma-in-the-retroperitoneum
#19
Ananthvikas Jayaram, Marie Therese Manipadam, Paul Mazhuvanchary Jacob
Anastomosing hemangiomas are a recently recognized benign vascular neoplasm, first described by Montgomery and Epstein in 2009. A few cases have been described in the genitourinary tract, especially in the renal hilum. These are fairly well-demarcated lesions with lobules of sinusoidal-like capillaries lined by hobnail endothelial cells containing eosinophilic hyaline globules in the cytoplasm. Extramedullary hematopoiesis has been described in a few cases, along with large feeding vessels. A predominant adipocytic component has been described in only one case...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29567327/origin-and-immunological-functions-of-spleen-stromal-cells
#20
REVIEW
Rachel Golub, Jonathan Tan, Takeshi Watanabe, Andrea Brendolan
The mammalian spleen is a peripheral lymphoid organ that plays a central role in host defense. Consequently, the lack of spleen is often associated with immunodeficiency and increased risk of overwhelming infections. Growing evidence suggests that non-hematopoietic stromal cells are central players in spleen development, organization, and immune functions. In addition to its immunological role, the spleen also provides a site for extramedullary hematopoiesis (EMH) in response to injuries. A deeper understanding of the biology of stromal cells is therefore essential to fully comprehend how these cells modulate the immune system during normal and pathological conditions...
March 19, 2018: Trends in Immunology
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