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https://www.readbyqxmd.com/read/27931169/a-mouse-model-of-bilateral-cervical-contusion-compression-spinal-cord-injury
#1
Nicole Forgione, Mahmood Chamankhah, Michael Fehlings
Cervical spinal cord injury (cSCI) occurs in over half of all cases of traumatic SCI, yet we lack therapies that can generate significant functional recovery in these patients. The development of animal models of cSCI will aid in the pre-clinical assessment of therapies and in understanding basic pathophysiological mechanisms. Here we describe a clinically relevant model of cervical contusion-compression injury in the mouse. Using a modified aneurism clip we generated a bilateral, incomplete injury that mimics contusion-compression injuries most commonly seen in humans...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27924753/referral-criteria-for-outpatient-specialty-palliative-cancer-care-an-international-consensus
#2
REVIEW
David Hui, Masanori Mori, Sharon M Watanabe, Augusto Caraceni, Florian Strasser, Tiina Saarto, Nathan Cherny, Paul Glare, Stein Kaasa, Eduardo Bruera
Although outpatient specialty palliative-care clinics improve outcomes, there is no consensus on who should be referred or the optimal timing for referral. In response to this issue, we did a Delphi study to develop consensus on a list of criteria for referral of patients with advanced cancer at secondary or tertiary care hospitals to outpatient palliative care. 60 international experts (26 from North America, 19 from Asia and Australia, and 11 from Europe) on palliative cancer care rated 39 needs-based criteria and 22 time-based criteria in three iterative rounds...
December 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27917700/posterior-reversible-encephalopathy-syndrome-following-elevated-mean-arterial-pressures-for-cervical-spinal-cord-injury
#3
Jeffrey H Zimering, Addisu Mesfin
BACKGROUND: Increasing the mean arterial pressure (MAP) is an accepted treatment modality to minimize the risk for irreversible neurologic damage secondary to spinal cord ischemia. Posterior reversible encephalopathy syndrome (PRES) is a rare complication occurring after transplantation surgery, in persons having an autoimmune disorder or after abrupt increases in blood pressure of various etiologies. STUDY DESIGN: Case report. METHODS: Retrospective evaluation of medical records...
December 5, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27917370/multiple-myeloma-like-spinal-mri-findings-in-skeletal-fluorosis-an-unusual-presentation-of-fluoride-toxicity-in-human
#4
Javed Ahsan Quadri, Mohd Meraj Alam, Saba Sarwar, Ashraf Ghanai, A Shariff, Taposh K Das
Endemic fluorosis is a worldwide environmental problem due to excessive fluoride, commonly due to increased drinking water fluoride levels but sometimes due to other sources such as food with high fluoride content. In India, 21 of the 35 states are known to have health problems associated with fluoride toxicity. The present report is a case of a 50-year-old female who was seen with progressive spinal complications and a MRI of the spine suggestive of multiple myeloma. The MRI of the lumbosacral spine showed a diffuse and heterogeneous marrow signal of the lower dorsal and lumbosacral vertebrae...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27917333/extensive-calcification-of-the-ligamentum-flavum-causing-cervical-myelopathy-in-a-caucasian-woman
#5
Milaine Roet, Jochem K H Spoor, M de Waal, Max J Kros, Sanjay B Harhangi, Ruben Dammers
Calcification of the ligamentum flavum (CLF) can cause myelopathy due to spinal cord compression. Only several cases in Caucasian patients have been described. Neurological deterioration can only be stopped by surgical decompression. We report a 63-year-old Caucasian woman presenting with progressive pins-and-needles sensations in both hands, worsened by painful paresthesia in both lower extremities. MRI showed a dorsal compressive mass extending from C2 to Th3 vertebrae with myelopathy at the level of C6. A laminectomy was performed, which improved clinical symptoms...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27912991/malignant-spinal-cord-compression-adapting-conventional-rehabilitation-approaches
#6
REVIEW
Lisa Marie Ruppert
Spinal tumors are classically grouped into 3 categories: extradural, intradural extramedullary, and intradural intramedullary. Spinal tumors may cause spinal cord compression and vascular compromise resulting in pain or neurologic compromise. They may also alter the architecture of the spinal column, resulting in spinal instability. Oncologic management of spinal tumors varies according to the stability of the spine, neurologic status, and presence of pain. Treatment options include surgical intervention, radiation therapy, chemotherapy, and hormonal manipulation...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27911069/-urological-pathology-of-lymphatic-origin
#7
A Domènech, A Serrano, I Forner-Cordero, F Gómez, D Maldonado, C Domínguez
OBJECTIVES: Lymphatic disease is a rarely cause of some very unspecific genitourinary manifestations, assuming a diagnostic challenge in most cases. The aim of this paper is to warn about the possible etiology of these urological lymphatic presentations and discuss its management. METHODS: Retrospective review of clinical data in pediatric patients with urological pathology of lymphatic origin between 2008-2014. Three patients, two boys and a girl, were included...
January 25, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27906951/changes-in-neuroglial-activity-in-multiple-spinal-segments-after-caudal-epidural-pulsed-radiofrequency-in-a-rat-model-of-lumbar-disc-herniation
#8
Hee Kyung Cho, Jae Hoon Kang, So-Yeon Kim, Mi-Jung Choi, Se Jin Hwang, Yun-Woo Cho, Sang-Ho Ahn
BACKGROUND: Herniated lumbar discs can induce sciatica by mechanical compression and/or chemical irritation. It was recently reported that neuroglial cellular activity after pulsed radiofrequency (PRF) application to a single dorsal root ganglion (DRG) attenuated neuroglial activity at the corresponding spinal dorsal horn. Recently, caudal epidural PRF has been used to manage neuropathic pain, but evidence of molecular changes after the administration of caudal epidural PRF to attenuate neuropathic pain is lacking, and it has not been determined whether caudal epidural PRF affects neuroglial activity at different spinal levels...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27905158/metastatic-spinal-cord-compression-from-basal-cell-carcinoma-of-the-skin-treated-with-surgical-decompression-and-vismodegib-case-report-and-review-of-hedgehog-signalling-pathway-inhibition-in-advanced-basal-cell-carcinoma
#9
J McGrane, S Carswell, T Talbot
We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous)...
November 30, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27903192/stereotactic-radiosurgery-for-idiopathic-glossopharyngeal-neuralgia-an-international-multicenter-study
#10
Hideyuki Kano, Dusan Urgosik, Roman Liscak, Bruce E Pollock, Or Cohen-Inbar, Jason P Sheehan, Mayur Sharma, Danilo Silva, Gene H Barnett, David Mathieu, Nathaniel D Sisterson, L Dade Lunsford
OBJECTIVE The goal of this study was to evaluate the outcomes of Gamma Knife stereotactic radiosurgery (SRS) when used for patients with intractable idiopathic glossopharyngeal neuralgia. METHODS Six participating centers of the International Gamma Knife Research Foundation identified 22 patients who underwent SRS for intractable glossopharyngeal neuralgia between 1998 and 2015. The median patient age was 60 years (range 34-83 years). The median duration of symptoms before SRS was 46 months (range 1-240 months)...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27902956/usefulness-of-cervical-computed-tomography-and-magnetic-resonance-imaging-for-rapid-diagnosis-of-crowned-dens-syndrome-a-case-report-and-review-of-the-literature
#11
Akihiro Inoue, Kanehisa Kohno, Satoko Ninomiya, Hitomi Tomita, Shinji Iwata, Shiro Ohue, Kenji Kamogawa, Kensho Okamoto, Shinya Fukumoto, Haruhisa Ichikawa, Shinji Onoue, Saya Ozaki, Bungo Okuda
INTRODUCTION: Crowned dens syndrome is a rare disease entity which radiologically shows calcification of the cruciform ligament around the odontoid process. We report a patient with crowned dens syndrome who improved dramatically in 5days following treatment with oral nonsteroidal anti-inflammatory medication. PRESENTATION OF CASE: A 61-year-old man was admitted to our hospital with a severe occipital headache and sudden onset of neck stiffness. Neurological examination on admission revealed a high fever and cervical rigidity...
November 23, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27896639/seom-clinical-guideline-for-bone-metastases-from-solid-tumours-2016
#12
C Grávalos, C Rodríguez, A Sabino, M Á Seguí, J A Virizuela, A Carmona, J Cassinello, D Isla, C Jara, M Martín
Bone metastases are common in many advanced solid tumours, being breast, prostate, thyroid, lung, and renal cancer the most prevalent. Bone metastases can produce skeletal-related events (SREs), defined as pathological fracture, spinal cord compression, need of bone irradiation or need of bone surgery, and hypercalcaemia. Patients with bone metastases experience pain, functional impairment and have a negative impact on their quality of life. Several imaging techniques are available for diagnosis of this disease...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27894942/-masson-s-haemangioma-an-unusual-cause-of-thoracic-compressive-myelopathy
#13
Bikash Ranjan Behera, Rabi Narayan Panda, Sanjib Mishra, Manmath Kumar Dhir
BACKGROUND: Masson's hemangioma is a rare pathological entity, featuring intravascular papillary endothelial hyperplasia. Although benign, this hemangioma grows to form an expansile compressing mass. This lesion is mostly seen in skin and subcutaneous tissue. Occurrence in neuraxis is rare for this pathological entity. Still rarer is the spinal location with only 5 case reports published till date in medical literature. CASE DESCRIPTION: Here we present a 26 year old male with paraplegia due to extradural compression at D4, D5 level...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27890761/the-coexistence-of-extradural-arteriovenous-fistula-and-soft-tissue-arteriovenous-malformation-within-the-same-metamere
#14
Nobuhiko Arai, Takenori Akiyama, Kazunari Yoshida
BACKGROUND: -Spinal arteriovenous shunts are a common spinal vascular disorder. However, they can have a misleading clinical presentation and poor prognosis. They are classified into 4 types according to shunt points and drainage route, among which extradural arteriovenous fistula (eAVF) is the most rare, comprising only 1% of all spinal arteriovenous shunts. Here, we report an extremely rare case of coexistent eAVF at the craniocervical junction and soft tissue arteriovenous malformation (AVM) within the same metamere...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27889959/fumaric-acid-esters-attenuate-secondary-degeneration-following-spinal-cord-injury
#15
Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Spinal cord injury (SCI) causes permanent changes in motor, sensory and autonomic functions. Unfortunately, there are not a stable cures and current treatments include surgical decompression, methylprednisolone and hemodynamic control that lead to modest function recovery. Fumaric acid esters (FAEs) were firstly used in the management of an immunological skin disorder, such as psoriasis. Because of their potent anti-inflammatory effects, they have been introduced in multiple sclerosis. Investigation shown not only anti-inflammatory, but also supposed neuroprotective mechanism of action...
November 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27879568/effect-of-immunotherapy-status-on-outcomes-in-patients-with-metastatic-melanoma-to-the-spine
#16
Ganesh M Shankar, Bryan D Choi, Benjamin L Grannan, Kevin Oh, John H Shin
STUDY DESIGN: Retrospective cohort study OBJECTIVE.: We performed a retrospective study of patients treated at our institution over the last 3 years to assess predictive value of immunotherapy exposure on overall survival of patients with metastatic melanoma to the spine in an effort to better inform surgical decision making. SUMMARY OF BACKGROUND DATA: Modern management of metastatic melanoma includes adjuvant targeted therapies and immunomodulators that have shown to significantly improve overall survival...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27879503/should-central-cord-syndrome-with-continued-spinal-cord-compression-without-a-fracture-undergo-urgent-24-h-surgical-decompression
#17
Markus Loibl, Frank Kleinstück, Hemil Maniar, Alpesh A Patel
No abstract text is available yet for this article.
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27875411/comparing-the-effectiveness-of-sagittal-balance-foraminal-stenosis-and-preoperative-cord-rotation-in-predicting-postoperative-c5-palsy
#18
Arunit J S Chugh, Douglas S Weinberg, Fernando Alonso, Jason D Eubanks
STUDY DESIGN: Retrospective cohort review. OBJECTIVE: To determine whether preoperative cord rotation is independently correlated with C5 palsy when analyzed alongside measures of sagittal balance and foraminal stenosis. SUMMARY OF BACKGROUND DATA: Postoperative C5 palsy is a well-documented complication of cervical procedures with a prevalence of 4%-8%. Recent studies have shown a correlation with preoperative spinal cord rotation. There have been few studies, however, that have examined the role of sagittal balance and foraminal stenosis in the development of C5 palsy...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27869449/-diffuse-tenosynovial-giant-cell-tumor-of-the-cervical-spine-destroying-vertebra-c6-a%C3%A2-case-report
#19
Zdeněk Kinkor, Tomáš Svoboda, Petr Grossman, David Bludovský, Filip Heidenreich, Andrej Švec, Iveta Mečiarová
Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27867117/extramedullar-cavernous-hemangioma-with-intra-and-extradural-growth-and-clinical-symptoms-of-brown-s%C3%A3-quard-syndrome-case-report-and-review-of-the-literature
#20
Bryndís Baldvinsdóttir, Gígja Erlingsdóttir, Ólafur Kjartansson, Ingvar Hákon Ólafsson
Primary spinal tumors are rare. Symptoms depend on size and location of the tumor. In the current case the patient presented with a rare clinical finding, Brown-Séquard syndrome. The symptoms were caused by an extramedullary tumor compressing on the thoracic spinal cord. Pathologic examination showed cavernous hemangioma, which had growth both intra- and extraduralt. This is an an extremely rare finding and to our knowledge only one case report has been published before were spinal cavernous hemangioma had intra- and extradural growth...
November 17, 2016: World Neurosurgery
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