Aisha Rashid, Muhammad Irfan, Yousaf Kamal, Sajid Asghar, Syed Haroon Khalid, Ghulam Hussain, Abdulrahman Alshammari, Thamer H Albekairi, Metab Alharbi, Hafeez Ullah Khan, Zunera Chauhdary, Thierry F Vandamme, Ikram Ullah Khan
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the simultaneous administration of H2 receptor antagonists such as ranitidine hydrochloride (RHCl) is obligatory. Here, we developed composite oral fast-disintegrating films (ODFs) containing FBP along with RHCl to provide a gastroprotective effect as well as to enhance the solubility and bioavailability of FBP...
January 24, 2024: Pharmaceutics