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https://www.readbyqxmd.com/read/29043142/costimulation-pathway-blockade-in-kidney-transplant-recipients-with-de-novo-rheumatoid-arthritis
#1
Mohamed Sheta, Samy Riad, Udayakumar Deepak, Naim Issa, Mark Birkenbach, Hassan N Ibrahim, Aleksandra Kukla
The best approach to treatment of de-novo rheumatoid arthritis in solid organ transplant recipients on typical immunosuppression is not well established. The use of biologics targeting specific cell types, cytokines, and immunological pathways has been gaining interest in the treatment of both, auto- and alloimmunity. We present a case of de-novo rheumatoid arthritis in a kidney transplant recipient 10 years post-transplant while receiving cyclosporine, mycophenolate mofetil, and also prednisone. Initial presentation included features of polymyalgia rheumatica and nephrotic range proteinuria...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29041910/takotsubo-cardiomyopathy-in-a-patient-with-ileus-a-case-report
#2
Chen-Yu C Guo, Nan-Sung Chou
BACKGROUND: Takotsubo cardiomyopathy (TCM) is a form of stress-induced cardiomyopathy featured by the dilatation of the apex of the left ventricle during systole. Whereas the pathogenesis of this disorder is not well understood, it usually occurs after an emotional or physical stress such as acute asthma, surgery, chemotherapy, and stroke. However, its occurrence in ileus patients is rarely reported. We hereby report probably the first case of TCM after ileus in the literature and discuss its implications...
October 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28990818/annals-express-serum-%C3%AE-melanocyte-stimulating-hormone-may-act-as-a-protective-biomarker-for-non-traumatic-osteonecrosis-of-the-femoral-head
#3
Zheng Mao, Gang Liu, Jing Jie Chen, Dan Liu, Min Peng Xu, Chang Zhao, Hai Tao Yang, Yong-Bin Yue
Background The α-Melanocyte stimulating hormone (α-MSH), an endogenous neuropeptide derived from proopiomelanocortin (POMC), has been identified to suppress inflammation and prevent osteoblast damage. Objective The present study was aimed to investigate the role of serum α-MSH in non-traumatic osteonecrosis of the femoral head (ONFH) . Methods 79 patients diagnosed with non-traumatic ONFH and 79 sex and age matched healthy controls were enrolled in the study. Serum α-MSH levels were examined with a double antibody radioimmunoassay...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28980482/the-utility-of-plain-films-for-nonoperative-fifth-metacarpal-fractures-are-follow-up-radiographs-necessary
#4
Nathanael Heckmann, Marie N Dusch, William C Pannell, Michael Bauschard, Ram K Alluri, Lakshmanan Sivasundaram, Alidad Ghiassi
BACKGROUND: Fifth metacarpal fractures are often treated nonoperatively with serial radiographs; however, the utility of these radiographs in altering clinical management has not been investigated. We hypothesize that follow-up plain films will not alter clinical management and are therefore unnecessary for most patients. METHODS: Between 2007 and 2014, patients with a fifth metacarpal fracture at our level I trauma center were retrospectively reviewed. Patients with inadequate documentation or imaging, ipsilateral upper extremity injuries, or who underwent initial surgical fixation were excluded...
October 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28972793/potential-discrepancy-between-plain-films-and-ct-scans-in-brooker-classification-of-heterotopic-ossification
#5
Mary Jiayi Tao, Linda Probyn, Michael Poon, Hans Kreader, Markku Nousiainen, Richard Jenkinson, Bo Angela Wan, Tsao May, Barnes Elizabeth, Edward Chow
OBJECTIVE: The Brooker Classification is a commonly used tool to characterize the extent of heterotopic ossification (HTO), which is the dystrophic formation of mature lamellar bone in non-osseous tissues such as muscles, connective tissue, or nerves. We aim to provide illustrative cases to describe the limitations and challenges of this system. METHODS: A retrospective review was conducted in all patients who had retrieved hip and/or pelvic radiotherapy for HTO prophylaxis at our institution between July 1998 and August 2016...
October 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28958364/radiology-for-trauma-and-the-general-surgeon
#6
REVIEW
Patrick K Kim
Conventional radiography (plain film), ultrasonography, and computed tomography (CT) are important modalities for the evaluation of patients with trauma. In meta-stable or unstable patients, the combination of chest radiograph, pelvis radiograph, and focused assessment for sonography in trauma (FAST) or extended FAST rapidly triages the torso. CT has become a standard for definitive imaging in blunt trauma. CT angiography is the modality of choice for suspected vascular injuries of the neck and extremities...
October 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28956142/exchange-nailing-with-enhanced-distal-fixation-is-effective-for-the-treatment-of-infraisthmal-femoral-nonunions
#7
Joon-Woo Kim, Yong-Cheol Yoon, Chang-Wug Oh, Seung-Beom Han, Jae-Ang Sim, Jong-Keon Oh
INTRODUCTION: The treatment options for nonunions of infraisthmal femoral shaft fractures after internal fixation are controversial. Methods such as exchanging an existing nail with a nail of a larger size, dynamization, removal of the nail followed by plating, and bone grafting have all been reported. Among those options, exchange nailing seems to be the most popular choice. In this study, a Poller screw, or an additional interlocking screw, was used in conjunction with exchange intramedullary nailing...
September 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28955978/monosialoganglioside-gm1-triggers-binding-of-the-amyloid-protein-salmon-calcitonin-to-a-langmuir-membrane-model-mimicking-the-occurrence-of-lipid-rafts
#8
Marco Diociaiuti, Cristiano Giordani, Gihan S Kamel, Francesco Brasili, Simona Sennato, Cecilia Bombelli, Karen Y Meneses, Marco A Giraldo, Federico Bordi
GM1 ganglioside is known to be involved in the amyloid-associated diseases and it is a crucial factor for the assembly of amyloid proteins on lipid-rafts, which are lipid structures located on the synaptic plasma membranes. Due to its slow aggregation rate, we employed salmon calcitonin (sCT) as a suitable probe representative of amyloid proteins, to study the interaction between this class of proteins and a membrane model. Here, we prepared a neuronal membrane model by depositing onto mica two Langmuir-Blodgett films in liquid-condensed phase: the outer monolayer was characterized by high content of GM1 (50%) and minority parts of cholesterol and POPC (25-25%), while the inner one by plain POPC...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28927979/enlarging-vascular-stents-after-pediatric-liver-transplantation
#9
Yi-Ting Yeh, Cheng-Yen Chen, Hsiou-Shan Tseng, Hsin-Kai Wang, Hsin-Lin Tsai, Niang-Cheng Lin, Chou-Fu Wei, Chinsu Liu
BACKGROUND: Endovascular intervention with stent placement to treat portal vein (PV) and hepatic vein (HV) stenosis after pediatric liver transplantation (LT) is still controversial in small children owing to the potential risk of functional stenosis after growth. The aim of this study is to evaluate the safety and efficacy of stent placement in this population. METHODS: Between 2004 and 2016, 6 children (all <3 years) received HV (n = 2) and PV (n = 4) stents placement among 46 pediatric LT patients at our institution...
September 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28924614/porcelain-gallbladder-often-an-overlooked-entity
#10
Sohail Iqbal, Sarfraz Ahmad, Usman Saeed, Mohammed Al-Dabbagh
Background  Porcelain gallbladder (GB) is a rare but potentially premalignant condition with minimal symptoms. Accident and Emergency (A&E) departments often tend to investigate abdominal pain through plain radiographs, which are occasionally reported by radiologists, thereby leaving behind few uncommon conditions, such as porcelain gallbladder unreported. Objectives  We present three cases of porcelain GB in which initial diagnosis was not considered due to the presence of various other calcifications in the upper abdomen...
October 2017: Surg J (N Y)
https://www.readbyqxmd.com/read/28924574/structural-similarity-index-family-for-image-quality-assessment-in-radiological-images
#11
Gabriel Prieto Renieblas, Agustín Turrero Nogués, Alberto Muñoz González, Nieves Gómez-Leon, Eduardo Guibelalde Del Castillo
The structural similarity index (SSIM) family is a set of metrics that has demonstrated good agreement with human observers in tasks using reference images. These metrics analyze the viewing distance, edge information between the reference and the test images, changed and preserved edges, textures, and structural similarity of the images. Eight metrics based on that family are proposed. This new set of metrics, together with another eight well-known SSIM family metrics, was tested to predict human performance in some specific tasks closely related to the evaluation of radiological medical images...
July 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28904726/radiographic-determination-of-cardiomegaly-using-cardiothoracic-ratio-and-transverse-cardiac-diameter-can-one-size-fit-all-part-one
#12
Edmund Kwadwo Kwakye Brakohiapa, Benard Ohene Botwe, Benjamin Dabo Sarkodie, Eric Kwesi Ofori, Jerry Coleman
INTRODUCTION: The cardio-thoracic ratio (CTR) and the transverse cardiac diameter (TCD) on Plain chest radiography are the two parameters commonly used to diagnose cardiomegaly and heart disease. A CTR of greater than 50% on a PA film is abnormal and normally indicates cardiac or pericardial disease condition, whiles an increase of TCD from 1.5 to 2cm on two consecutive radiographs, taken at short interval, suggests possible cardiac pathology. The aim was to determine the suitability of using the same TCD and CTR to detect cardiomegaly for all age groups and genders respectively...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28894995/ibuprofen-loaded-fibrous-patches-taming-inhibition-at-the-spinal-cord-injury-site
#13
Liliana R Pires, Cátia D F Lopes, Daniela Salvador, Daniela N Rocha, Ana Paula Pêgo
It is now widely accepted that a therapeutic strategy for spinal cord injury (SCI) demands a multi-target approach. Here we propose the use of an easily implantable bilayer polymeric patch based on poly(trimethylene carbonate-co-ε-caprolactone) (P(TMC-CL)) that combines physical guidance cues provided by electrospun aligned fibres and the delivery of ibuprofen, as a mean to reduce the inhibitory environment at the lesion site by taming RhoA activation. Bilayer patches comprised a solvent cast film onto which electrospun aligned fibres have been deposited...
September 11, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28890374/physico-mechanical-and-structural-properties-of-eggshell-membrane-gelatin-chitosan-blend-edible-films
#14
Reza Mohammadi, Mohammad Amin Mohammadifar, Milad Rouhi, Mohaddeseh Kariminejad, Amir Mohammad Mortazavian, Ehsan Sadeghi, Sara Hasanvand
This study investigated the physico-mechanical and structural properties of composite edible films based on eggshell membrane gelatin (G) and chitosan (Ch) (75G:25Ch, 50G:50Ch, 25G:75Ch). The results demonstrated that the addition of Ch increased elongation at break significantly (p<0.05), but resulted in no significant change in tensile strength (TS) using 75G:25Ch, 50G:50Ch mixtures in comparison with gelatin-based film. The water solubility and water vapor permeability of the 50G:50Ch film decreased significantly compared to plain films (100G:0Ch and 0G:100Ch) and other composite films (p<0...
September 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28882933/caecal-cancer-presenting-as-leg-erythema-and-a-lung-opacity
#15
Archik Das, Khalid Hureibi, Muhammad Tayyab, Peter McCullough
Necrotising infection of the lower limb is a rare presentation for colorectal malignancy. We report a case of a perforated caecal adenocarcinoma presenting with right leg erythema, pain and swelling in the presence of a right lower lobe lung opacity. Following initial debridement and washout, CT imaging demonstrated a thickened terminal ileum, caecum and appendix, in keeping with primary malignancy. This fed the right-sided lower limb sepsis tracking down from the medial aspect of the psoas muscle to give rise to the multiloculated collection seen in the adductor compartment...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28853279/transforming-commercial-textiles-and-threads-into-sewable-and-weavable-electric-heaters
#16
Lushuai Zhang, Morgan Baima, Trisha L Andrew
We describe a process to transform commercial textiles and threads into electric heaters that can be cut/sewn or woven to fashion lightweight fabric heaters for local climate control and personal thermal management. Off-the-shelf fabrics are coated with a 1.5 μm thick film of a conducting polymer, poly(3,4-ethylenedioxythiophene), using an improved reactive vapor deposition method. Changes in the hand feel, weight, and breathability of the textiles after the coating process are imperceptible. The resulting fabric electrodes possess competitively low sheet resistances-44 Ω/□ measured for coated bast fiber textiles and 61 Ω/□ measured for coated cotton textiles-and act as low-power-consuming Joule heating elements...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28852362/visual-interpretation-of-plain-radiographs-in-orthopaedics-using-eye-tracking-technology
#17
Jessica Hanley, David Warren, Natalie Glass, Daniel Tranel, Matthew Karam, Joseph Buckwalter
BACKGROUND: Despite the importance of radiographic interpretation in orthopaedics, there not a clear understanding of the specific visual strategies used while analyzing a plain film. Eyetracking technology allows for the objective study of eye movements while performing a dynamic task, such as reading X-rays. Our study looks to elucidate objective differences in image interpretation between novice and experienced orthopaedic trainees using this novel technology. METHODS: Novice and experienced orthopaedic trainees (N=23) were asked to interpret AP pelvis films, searching for unilateral acetabular fractures while eye-movements were assessed for pattern of gaze, fixation on regions of interest, and time of fixation at regions of interest...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28841904/a-comparison-of-radiographic-and-clinical-outcomes-of-anterior-lumbar-interbody-fusion-performed-with-either-a-cellular-bone-allograft-containing-multipotent-adult-progenitor-cells-or-recombinant-human-bone-morphogenetic-protein-2
#18
Daniel Dongwhan Lee, John Yongmin Kim
BACKGROUND: Both the map3 Cellular Allogeneic Bone Graft® and recombinant human bone morphogenetic protein 2 (rhBMP-2, Infuse®) were developed to provide an alternative to iliac crest autograft, thus eliminating the morbidity associated with its harvest. The recent literature concerning adverse events associated with the use of rhBMP-2, however, highlights the need for a safe and effective alternative. The multipotent adult progenitor cells (MAPC) found in map3 allograft may provide this alternative...
August 25, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28841465/design-of-a-nanocomposite-substrate-inducing-adult-stem-cell-assembly-and-progression-toward-an-epiblast-like-or-primitive-endoderm-like-phenotype-via-mechanotransduction
#19
Francesco Morena, Ilaria Armentano, Pia Montanucci, Chiara Argentati, Elena Fortunati, Simona Montesano, Ilaria Bicchi, Teresa Pescara, Ilaria Pennoni, Samantha Mattioli, Luigi Torre, Loredana Latterini, Carla Emiliani, Giuseppe Basta, Riccardo Calafiore, Josè Maria Kenny, Sabata Martino
This work shows that the active interaction between human umbilical cord matrix stem cells and Poly (l-lactide)acid (PLLA) and PLLA/Multi Walled Carbon Nanotubes (MWCNTs) nanocomposite films results in the stem cell assembly as a spheroid conformation and affects the stem cell fate transition. We demonstrated that spheroids directly respond to a tunable surface and the bulk properties (electric, dielectric and thermal) of plain and nanocomposite PLLA films by triggering a mechanotransduction axis. This stepwise process starts from tethering of the cells' focal adhesion proteins to the surface, together with the adherens junctions between cells...
August 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28816298/-multiple-endoscopy-for-the-treatment-of-upper-urinary-tract-calculi-following-ileal-conduit-a-case-report-and-literature-review
#20
B Wang, J F Ye, L Zhao, H Bi, J Lu, L L Ma
Upper urinary tract calculi with infection is a quite difficult acute urologic emergency. And what is more, upper urinary tract obstruction after radical cystectomy following urinary diversion may be fatal in the vulnerable patients with this kind of situation. Postoperative anatomy and other factors affect the upper urinary tract calculi, and urinary tract infection greatly increased the risk. But it is particularly difficult to handle with patients with poor general condition and septic shock treatment, so how to optimize the selection program is worth further studying...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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