keyword
https://read.qxmd.com/read/38485619/lipid-association-of-india-2023-update-on-cardiovascular-risk-assessment-and-lipid-management-in-indian-patients-consensus-statement-iv
#1
JOURNAL ARTICLE
Raman Puri, Manish Bansal, Vimal Mehta, P Barton Duell, Nathan D Wong, S S Iyengar, Dinesh Kalra, Devaki R Nair, Navin C Nanda, Jagat Narula, P Deedwania, Jamal Yusuf, Jamshed J Dalal, Sadanand Shetty, Vinod M Vijan, Rajeev Agarwala, Soumitra Kumar, Kris Vijay, Aziz Khan, Gurpreet Singh Wander, P C Manoria, S K Wangnoo, Viswanathan Mohan, Shashank R Joshi, Balbir Singh, Prafulla Kerkar, Rajesh Rajput, D Prabhakar, Abdul Hamid Zargar, Banshi Saboo, Ravi R Kasliwal, Saumitra Ray, Sandeep Bansal, M U Rabbani, Shibba Takkar Chhabra, Sarat Chandra, Neil Bardoloi, Narasaraju Kavalipati, Immaneni Sathyamurthy, Kunal Mahajan, Akshya Pradhan, N N Khanna, Rajesh Khadgawat, Preeti Gupta, Milan C Chag, Ashu Gupta, A Murugnathan, S N Narasingan, Sundeep Upadhyaya, Vinod Mittal, Rashida Patanwala Melinkeri, Madhur Yadav, M Raseed Mubarak, K K Pareek, Pradeep Kumar Dabla, Rashmi Nanda, J C Mohan
OBJECTIVE: In 2016, the Lipid Association of India (LAI) developed a cardiovascular risk assessment algorithm and defined low-density lipoprotein cholesterol (LDL-C) goals for prevention of atherosclerotic cardiovascular disease (ASCVD) in Indians. The recent refinements in the role of various risk factors and subclinical atherosclerosis in prediction of ASCVD risk necessitated updating the risk algorithm and treatment goals. METHODS: The LAI core committee held twenty-one meetings and webinars from June 2022 to July 2023 with experts across India and critically reviewed the latest evidence regarding the strategies for ASCVD risk prediction and the benefits and modalities for intensive lipid lowering...
February 8, 2024: Journal of Clinical Lipidology
https://read.qxmd.com/read/38460548/biomarker-analysis-from-the-phase-2b-randomized-placebo-controlled-trial-of-riociguat-in-early-diffuse-cutaneous-systemic-sclerosis
#2
JOURNAL ARTICLE
Dinesh Khanna, Frank Kramer, Josef Höfler, Mercedeh Ghadessi, Peter Sandner, Yannick Allanore, Christopher P Denton, Masataka Kuwana, Marco Matucci-Cerinic, Janet E Pope, Tatsuya Atsumi, Radim Bečvář, László Czirják, Ellen De Langhe, Eric Hachulla, Tomonori Ishii, Osamu Ishikawa, Sindhu R Johnson, Valeria Riccieri, Elena Schiopu, Richard M Silver, Vanessa Smith, Chiara Stagnaro, Virginia Steen, Wendy Stevens, Gabriella Szücs, Marie-Elise Truchetet, Melanie Wosnitza, Oliver Distler
OBJECTIVE: To examine disease and target engagement biomarkers in the RISE-SSc trial of riociguat in early diffuse cutaneous systemic sclerosis and their potential to predict the response to treatment. METHODS: Patients were randomized to riociguat (n = 60) or placebo (n = 61) for 52 weeks. Skin biopsies and plasma/serum samples were obtained at baseline and week 14. Plasma cyclic guanosine monophosphate (cGMP) was assessed using radio-immunoassay...
March 9, 2024: Rheumatology
https://read.qxmd.com/read/38401617/addition-of-surgeon-administered-adductor-canal-infiltration-to-the-periarticular-infiltration-in-total-knee-arthroplasty-effect-on-pain-and-early-outcomes
#3
JOURNAL ARTICLE
Maniar Adit R, Khokhar Ashwini, Nayak Akshay, Kumar Dinesh, Ishan Khanna, Maniar Rajesh N
INTRODUCTION: Our aim was to study the additive effect of surgeon administered adductor canal infiltration (SACI) over routine periarticular infiltration PAI on pain control [morphine consumption and pain score by Visual Analogue scale (VAS)] and early function [flexion and Timed Up and Go (TUG) test] post- total knee arthroplasty (TKA). METHODS: We prospectively randomized 60 patients into two groups. Group I patients received the standard PAI, whereas in Group II, the patients received a SACI in addition to the PAI...
February 22, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38333526/exploratory-clinical-subgroup-clustering-in-systemic-sclerosis-results-from-the-indian-progressive-systemic-sclerosis-registry
#4
JOURNAL ARTICLE
Shery Susan Philip, Ramya Janardana, Padmanabha Shenoy, Chengappa Kavadichanda, Devender Bairwa, Geetabali Sircar, Parasar Ghosh, Anupam Wakhlu, Sumithra Selvam, Dinesh Khanna, Vineeta Shobha
OBJECTIVE: To conduct an exploratory cluster analysis of systemic sclerosis patients from the baseline data of the Indian systemic sclerosis registry. METHODS: Patients satisfying American College of Rheumatology-European League Against Rheumatism classification criteria for systemic sclerosis were included. The clusters formed using clinical and immunological parameters were compared. RESULTS: Of the 564 systemic sclerosis registry participants, 404 patients were included...
February 2024: Journal of Scleroderma and related Disorders
https://read.qxmd.com/read/38251553/the-role-of-skin-ultrasound-in-systemic-sclerosis-looking-below-the-surface-to-understand-disease-evolution
#5
REVIEW
Gemma Lepri, Michael Hughes, Yannick Allanore, Christopher P Denton, Daniel E Furst, Yukai Wang, Tânia Santiago, Ilaria Galetti, Francesco Del Galdo, Dinesh Khanna, Marco Matucci-Cerinic
Skin ultrasound has shown promising results in the evaluation of skin involvement in patients with systemic sclerosis, as substantiated by a recent systematic literature review from the World Scleroderma Foundation Skin Ultrasound Working Group. In this Viewpoint, we will discuss the role of ultrasound in evaluating skin involvement in patients with systemic sclerosis, particularly the possibility of using this technique to detect an early subclinical skin involvement from the very early phase, suggesting its possible use in both diagnosis and disease follow-up...
July 2023: Lancet Rheumatology
https://read.qxmd.com/read/38251534/beyond-very-early-systemic-sclerosis-deciphering-pre%C3%A2-scleroderma-and-its-trajectories-to-open-new-avenues-for-preventive-medicine
#6
REVIEW
Alain Lescoat, Silvia Bellando-Randone, Corrado Campochiaro, Francesco Del Galdo, Christopher P Denton, Sue Farrington, Ilaria Galetti, Dinesh Khanna, Masataka Kuwana, Marie-Elise Truchetet, Yannick Allanore, Marco Matucci-Cerinic
The identification of individuals with systemic sclerosis in an oligosymptomatic phase preceding the very early manifestations of the disease represents a challenge in the search for a new window of opportunity in systemic sclerosis. This phase could be identified in a clinical scenario as the pre-scleroderma phase, in which the disease would still be far from systemic sclerosis-related fibrotic or irreversible manifestations in skin or organs. In this Personal View, we discuss parameters and candidate definitions for a conceptual framework of pre-scleroderma, from the identification of populations at risk to autoantibodies and their potential functional activities...
November 2023: Lancet Rheumatology
https://read.qxmd.com/read/38251533/riociguat-in-patients-with-early-diffuse-cutaneous-systemic-sclerosis-rise-ssc-open-label-long-term-extension-of-a-phase-2b-randomised-placebo-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Oliver Distler, Yannick Allanore, Christopher P Denton, Masataka Kuwana, Marco Matucci-Cerinic, Janet E Pope, Tatsuya Atsumi, Radim Bečvář, László Czirják, Eric Hachulla, Tomonori Ishii, Osamu Ishikawa, Sindhu R Johnson, Ellen De Langhe, Chiara Stagnaro, Valeria Riccieri, Elena Schiopu, Richard M Silver, Vanessa Smith, Virginia Steen, Wendy Stevens, Gabriella Szücs, Marie-Elise Truchetet, Melanie Wosnitza, Kaisa Laapas, Frank Kramer, Dinesh Khanna
BACKGROUND: The phase 2b Riociguat Safety and Efficacy in Patients with Diffuse Cutaneous Systemic Sclerosis (RISE-SSc) trial investigated riociguat versus placebo in early diffuse cutaneous systemic sclerosis. The long-term extension evaluated safety and exploratory treatment effects for an additional year. METHODS: Patients were enrolled to RISE-SSc between Jan 15, 2015, and Dec 8, 2016. Those who completed the 52-week, randomised, parallel-group, placebo-controlled, double-blind phase were eligible for the long-term extension...
November 2023: Lancet Rheumatology
https://read.qxmd.com/read/38244446/baseline-absolute-monocyte-count-predicts-lung-function-decline-among-patients-with-systemic-sclerosis-associated-interstitial-lung-disease-a-post-hoc-analysis-from-the-focussced-trial
#8
JOURNAL ARTICLE
Elana J Bernstein, Christopher P Denton, Suiyuan Huang, Dinesh Khanna
OBJECTIVE: Interstitial lung disease (ILD) is the leading cause of death in adults with systemic sclerosis (SSc). The identification of biomarkers to predict progression of SSc-ILD is an important unmet need. The purpose of this study was to determine whether an elevated baseline absolute monocyte count (AMC) is associated with a decline in forced vital capacity (FVC) at 48 weeks among participants with SSc-ILD enrolled in the phase 3 focuSSced trial. METHODS: We performed a post-hoc analysis of the focuSSced trial, a multicenter, double-blind, randomized, placebo-controlled trial of adults with diffuse cutaneous SSc for ≤ 60 months...
January 14, 2024: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/38172207/systems-based-identification-of-the-hippo-pathway-for-promoting-fibrotic-mesenchymal-differentiation-in-systemic-sclerosis
#9
JOURNAL ARTICLE
Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A Hile, Paul W Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L Modlin, John Varga, Lam C Tsoi, Robert Lafyatis, J Michelle Kahlenberg, Allison C Billi, Dinesh Khanna, Johann E Gudjonsson
Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SSc skin fibrosis remain incompletely understood. Here using differentiation trajectories at a single cell level, we demonstrate a dual source of extracellular matrix deposition in SSc skin from both myofibroblasts and endothelial-to-mesenchymal-transitioning cells (EndoMT)...
January 3, 2024: Nature Communications
https://read.qxmd.com/read/38146100/performance-of-detect-pah-algorithm-according-to-the-hemodynamic-definition-of-pulmonary-arterial-hypertension-pah-in-the-2022-esc-ers-guidelines-early-detection-of-pulmonary-arterial-hypertension-in-systemic-sclerosis-patients
#10
JOURNAL ARTICLE
Oliver Distler, Diana Bonderman, J Gerry Coghlan, Christopher P Denton, Ekkehard Grünig, Dinesh Khanna, Vallerie V McLaughlin, Ulf Müller-Ladner, Janet E Pope, Madelon C Vonk, Lilla Di Scala, Jean-Christophe Lemarie, Loïc Perchenet, Éric Hachulla
OBJECTIVE: The evidence-based DETECT pulmonary arterial hypertension (PAH) algorithm is frequently used in systemic sclerosis (SSc) patients to help clinicians screen for PAH by using non-invasive data to recommend patient referral to echocardiography, and if applicable, for a diagnostic right heart catheterization (RHC). However, the hemodynamic definition of PAH was recently updated in the 2022 ESC/ERS guidelines. The performance of DETECT PAH in identifying patients with a high risk of PAH according to this new definition was assessed...
December 25, 2023: Arthritis & Rheumatology
https://read.qxmd.com/read/38078805/modulation-of-singlet-triplet-gap-in-atomically-precise-silver-cluster-assembled-material
#11
JOURNAL ARTICLE
Priyanka Chandrashekar, Gopa Sardar, Turbasu Sengupta, Arthur C Reber, Pradip Kumar Mondal, Dinesh Kabra, Pravas Deria, Shiv N Khanna, Sukhendu Mandal
Silver cluster-based solids have garnered considerable attention owing to their tunable luminescence behavior. While surface modification has enabled the construction of stable silver clusters, controlling interactions among clusters at the molecular level has been challenging due to their tendency to aggregate. Judicious choice of stabilizing ligands becomes pivotal in crafting a desired assembly. However, detailed photophysical behavior as a function of their cluster packing remained unexplored. Here, we modulate the packing pattern of Ag12 clusters by varying the nitrogen-based ligand...
December 11, 2023: Angewandte Chemie
https://read.qxmd.com/read/37956387/osteosarcoma-explorer-a-data-commons-with-clinical-genomic-protein-and-tissue-imaging-data-for-osteosarcoma-research
#12
JOURNAL ARTICLE
Donghan M Yang, Qinbo Zhou, Lauren Furman-Cline, Xian Cheng, Danni Luo, Hongyin Lai, Yueqi Li, Kevin W Jin, Bo Yao, Patrick J Leavey, Dinesh Rakheja, Tammy Lo, David Hall, Donald A Barkauskas, David S Shulman, Katherine Janeway, Chand Khanna, Richard Gorlick, Christopher Menzies, Xiaowei Zhan, Guanghua Xiao, Stephen X Skapek, Lin Xu, Laura J Klesse, Brian D Crompton, Yang Xie
PURPOSE: Osteosarcoma research advancement requires enhanced data integration across different modalities and sources. Current osteosarcoma research, encompassing clinical, genomic, protein, and tissue imaging data, is hindered by the siloed landscape of data generation and storage. MATERIALS AND METHODS: Clinical, molecular profiling, and tissue imaging data for 573 patients with pediatric osteosarcoma were collected from four public and institutional sources. A common data model incorporating standardized terminology was created to facilitate the transformation, integration, and load of source data into a relational database...
September 2023: JCO Clinical Cancer Informatics
https://read.qxmd.com/read/37867940/an-interleukin-6-responsive-plasma-cell-signature-is-associated-with-disease-progression-in-systemic-sclerosis-interstitial-lung-disease
#13
JOURNAL ARTICLE
Guiquan Jia, Thirumalai R Ramalingam, Jason Vander Heiden, Xia Gao, Daryle DePianto, Katrina B Morshead, Zora Modrusan, Nandhini Ramamoorthi, Paul Wolters, Celia Lin, Dinesh Khanna, Joseph R Arron
Systemic sclerosis (SSc) interstitial lung disease (ILD) is among the leading causes of SSc-related morbidity and mortality. Tocilizumab (TCZ, anti-IL6RA) has demonstrated a reduced rate of pulmonary function decline in two phase 2/3 trials (faSScinate and focuSSced) in SSc-ILD patients. We performed transcriptome analysis of skin biopsy samples collected in the studies to decipher gene networks that were potentially associated with clinical responses to TCZ treatment. One module correlated with disease progression showed pharmacodynamic changes with TCZ treatment, and was characterized by plasma cell (PC) genes...
November 17, 2023: IScience
https://read.qxmd.com/read/37846437/effects-of-a-resilience-building-energy-management-program-on-fatigue-and-other-symptoms-in-systemic-sclerosis-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Susan L Murphy, Yen T Chen, Mary Alore, Sheri Hicks, Adam Pape, Afton L Hassett, Anna L Kratz, Daniel Whibley, Alexandra E Harper, Suiyuan Huang, Gina Jay, Shannen Bolde, Dinesh Khanna
OBJECTIVE: Supported self-management interventions for individuals with systemic sclerosis (SSc) are needed. We examined effects of a 12-week resilience-building, energy management program (called RENEW) for fatigue and other patient-reported outcomes. METHODS: Participants, who had physician-diagnosed SSc, moderate to severe fatigue, and were ≥ 18 years old, were randomly assigned to RENEW or waitlist control in a 2:1 ratio. The RENEW intervention included an educational website/app plus 9 virtual peer-led health coaching sessions...
October 17, 2023: Arthritis Care & Research
https://read.qxmd.com/read/37826898/surgical-management-of-digital-ulcers-in-systemic-sclerosis-a-systematic-literature-review
#15
REVIEW
Yossra A Suliman, Corrado Campochiaro, Michael Hughes, Jan W Schoones, Dilia Giuggioli, Pia Moinzadeh, Murray Baron, Lorinda Chung, Laura Ross, Nancy Maltez, Yannick Allanore, Christopher P Denton, Oliver Distler, Tracy Frech, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Masataka Kuwana, Marco Matucci-Cerinic, Janet Pope, Alessia Alunno
BACKGROUND: There is a strong rationale to develop locally-acting surgical treatments for digital ulcers (DUs) in patients with systemic sclerosis (SSc). Our aim was to examine the safety and efficacy of local surgical management for SSc-DU. METHODS: A systematic literature review was carried out until to August 2022 using 7 different databases. Original research studies concerning adult patients with SSc-DUs, and local surgical treatments were analysed using the PICO framework...
September 26, 2023: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/37794717/economic-and-health-care-resource-use-burden-of-systemic-sclerosis
#16
JOURNAL ARTICLE
Dinesh Khanna, Daniel E Furst, Justin W Li, Qian Meng, Yuan Yuan, Tamara Lesperance, Kenyatta Peoples, Farah Ali, Brian LaMoreaux, Stephanie D Taylor
OBJECTIVE: To describe the health care resource use (HCRU) and costs of patients with systemic sclerosis (SSc) prior to and after diagnosis. METHODS: This retrospective study used a claims data set (Merative MarketScan; 2015-2019). Eligible patients with SSc were identified by diagnosis codes and required at least 24 months of enrollment without an SSc diagnosis before their first SSc claim and at least 12 months of enrollment thereafter. Total HCRU and costs were reported for three intervals: 2 years and 1 year before and 1 year after index diagnosis...
October 4, 2023: ACR open rheumatology
https://read.qxmd.com/read/37778090/non-surgical-local-treatments-of-digital-ulcers-in-systemic-sclerosis-a-systematic-literature-review
#17
REVIEW
Corrado Campochiaro, Yossra A Suliman, Michael Hughes, Jan W Schoones, Dilia Giuggioli, Pia Moinzadeh, Murray Baron, Lorinda Chung, Laura Ross, Nancy Maltez, Yannick Allanore, Christopher P Denton, Oliver Distler, Tracy Frech, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Masataka Kuwana, Marco Matucci-Cerinic, Janet Pope, Alessia Alunno
INTRODUCTION: Digital ulcers (DUs) are difficult to treat in patients with systemic sclerosis (SSc) and systemic (i.e., pharmacological) therapy is currently considered the 'standard of care'. Our aim was to examine the safety and efficacy of local, non-surgical treatment for SSc-DUs. METHODS: A systematic literature review (SLR) of original research articles up to August, 29 2022 was performed according to the PICO framework. References were independently screened by two reviewers and risk of bias was assed using validated tools...
December 2023: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/37744047/consensus-on-the-assessment-of-systemic-sclerosis-associated-primary-heart-involvement-world-scleroderma-foundation-heart-failure-association-guidance-on-screening-diagnosis-and-follow-up-assessment
#18
REVIEW
Cosimo Bruni, Maya H Buch, Aleksandra Djokovic, Giacomo De Luca, Raluca B Dumitru, Alessandro Giollo, Ilaria Galetti, Alexia Steelandt, Konstantinos Bratis, Yossra Atef Suliman, Ivan Milinkovic, Anna Baritussio, Ghadeer Hasan, Anastasia Xintarakou, Yohei Isomura, George Markousis-Mavrogenis, Sophie Mavrogeni, Luna Gargani, Alida Lp Caforio, Carsten Tschöpe, Arsen Ristic, Sven Plein, Elijah Behr, Yannick Allanore, Masataka Kuwana, Christopher P Denton, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Renzo Marcolongo, Alessia Pepe, Oliver Distler, Petros Sfikakis, Petar Seferovic, Marco Matucci-Cerinic
INTRODUCTION: Heart involvement is a common problem in systemic sclerosis. Recently, a definition of systemic sclerosis primary heart involvement had been proposed. Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients. METHODS: A systematic literature review was performed to investigate the tests used to evaluate heart involvement in systemic sclerosis. The extracted data were categorized into relevant domains (conventional radiology, electrocardiography, echocardiography, cardiac magnetic resonance imaging, laboratory, and others) and presented to experts and one patient research partner, who discussed the data and added their opinion...
October 2023: Journal of Scleroderma and related Disorders
https://read.qxmd.com/read/37507209/patient-level-factors-predictive-of-interstitial-lung-disease-in-rheumatoid-arthritis-a-systematic-review
#19
JOURNAL ARTICLE
Eric L Matteson, Marco Matucci-Cerinic, Michael Kreuter, Gerd R Burmester, Philippe Dieudé, Paul Emery, Yannick Allanore, Janet Pope, Dinesh Khanna
Objective Interstitial lung disease (ILD) is an important cause of mortality in some patients with rheumatoid arthritis (RA). Patient-level factors may predict which patients with RA are at the highest risk of developing ILD and are therefore candidates for screening for this complication of the underlying disease. Methods A systematic literature review was performed using PubMed, Embase and Scopus over a 10-year period up to July 2021. Publications reporting patient-level factors in patients with RA with and without ILD that were assessed before development of ILD (or were unchanged over time and therefore could be extrapolated to before development of ILD) were retrieved for assessment of evidence...
July 2023: RMD Open
https://read.qxmd.com/read/37497718/the-collaborative-national-quality-and-efficacy-registry-for-scleroderma-association-of-medication-use-on-gastrointestinal-tract-symptoms-in-early-disease-and-the-importance-of-tobacco-cessation
#20
JOURNAL ARTICLE
Sarah Luebker, Tracy M Frech, Shervin Assassi, Jessica K Gordon, Elana J Bernstein, Virginia D Steen, Ami A Shah, Laura K Hummers, Carrie Richardson, Dinesh Khanna, Flavia V Castelino, Lorinda Chung, Faye N Hant, Victoria K Shanmugam, John M VanBuren, Jessica Alvey, Monica Harding, Nora Sandorfi
OBJECTIVES: Systemic Sclerosis (SSc) is frequently associated with gastrointestinal tract (GIT) involvement. The Collaborative National Quality and Efficacy Registry (CONQUER) is a US-based collaborative study collecting longitudinal follow up data on SSc patients with less than 5-years disease duration enrolled at Scleroderma centres of excellence. This manuscript presents the GIT natural history and outcomes in relation to other scleroderma manifestations and medication exposures. METHODS: CONQUER participants that had completed a minimum of two serial Scleroderma Clinical Trials Consortium GIT Questionnaires (GIT 2...
August 2023: Clinical and Experimental Rheumatology
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