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https://www.readbyqxmd.com/read/28930362/rapid-development-of-specialty-population-registries-and-quality-measures-from-electronic-health-record-data-an-agile-framework
#1
Vaishnavi Kannan, Jason S Fish, Jacqueline M Mutz, Angela R Carrington, Ki Lai, Lisa S Davis, Josh E Youngblood, Mark R Rauschuber, Kathryn A Flores, Evan J Sara, Deepa G Bhat, DuWayne L Willett
BACKGROUND: Creation of a new electronic health record (EHR)-based registry often can be a "one-off" complex endeavor: first developing new EHR data collection and clinical decision support tools, followed by developing registry-specific data extractions from the EHR for analysis. Each development phase typically has its own long development and testing time, leading to a prolonged overall cycle time for delivering one functioning registry with companion reporting into production. The next registry request then starts from scratch...
June 14, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28930263/salicylate-poisoning-potential-of-topical-pain-relief-agents-from-age-old-remedies-to-engineered-smart-patches
#2
REVIEW
Ashleigh Anderson, Aaron McConville, Laura Fanthorpe, James Davis
The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse...
June 30, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928936/exploring-differential-evolution-for-inverse-qsar-analysis
#3
Tomoyuki Miyao, Kimito Funatsu, Jürgen Bajorath
Inverse quantitative structure-activity relationship (QSAR) modeling encompasses the generation of compound structures from values of descriptors corresponding to high activity predicted with a given QSAR model. Structure generation proceeds from descriptor coordinates optimized for activity prediction. Herein, we concentrate on the first phase of the inverse QSAR process and introduce a new methodology for coordinate optimization, termed differential evolution (DE), that originated from computer science and engineering...
2017: F1000Research
https://www.readbyqxmd.com/read/28928907/adipose-derived-stromal-cell-in-regenerative-medicine-a-review
#4
REVIEW
Reza Tabatabaei Qomi, Mohsen Sheykhhasan
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells (ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years...
August 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28925020/one-pot-synthesis-of-size-controllable-core-shell-cds-and-derivative-cds-znxcd1-xs-structures-for-dramatic-photocatalytic-hydrogen-production
#5
Shuangshuang Kai, Baojuan Xi, Yifeng Wang, Shenglin Xiong
Chalcogenide micro/nano composite structures have been attracting world-wide attention due to the enormous prospect of applications in photocatalytic hydrogen production. Well-defined micro/nanostructures, featured with predominant properties, are of extraordinary importance. Herein, we reported a facile one-pot method on synthesis of monodispersed size-controllable CdS and CdS@ZnxCd1-xS core-shell submicrospheres, which were engineered with respect to the structural conformation and size. CdS core-shell submicrospheres with different size were selectively prepared for the first time...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28923958/multiscale-characterization-of-the-mineral-phase-at-skeletal-sites-of-breast-cancer-metastasis
#6
Frank He, Aaron E Chiou, Hyun Chae Loh, Maureen Lynch, Bo Ri Seo, Young Hye Song, Min Joon Lee, Rebecca Hoerth, Emely L Bortel, Bettina M Willie, Georg N Duda, Lara A Estroff, Admir Masic, Wolfgang Wagermaier, Peter Fratzl, Claudia Fischbach
Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with the mineralized bone extracellular matrix. Bone mineral is largely composed of hydroxyapatite (HA) nanocrystals with physicochemical properties that vary significantly by anatomical location, age, and pathology. However, it remains unclear whether bone regions typically targeted by metastatic breast cancer feature distinct HA materials properties. Here we combined high-resolution X-ray scattering analysis with large-area Raman imaging, backscattered electron microscopy, histopathology, and microcomputed tomography to characterize HA in mouse models of advanced breast cancer in relevant skeletal locations...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923495/crispr-cas9-engineering-of-adult-mouse-liver-demonstrates-that-the-dnajb1-prkaca-gene-fusion-is-sufficient-to-induce-tumors-resembling-fibrolamellar-hepatocellular-carcinoma
#7
Lars H Engelholm, Anjum Riaz, Denise Serra, Frederik Dagnæs-Hansen, Jens V Johansen, Eric Santoni-Rugiu, Steen H Hansen, Francesco Niola, Morten Frödin
BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver cancer that predominantly affects young adults with no underlying liver disease. A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1) to the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedly identified in patients with FL-HCC. However, the DNAJB1-PRKACA gene fusion has not been shown to induce liver tumorigenesis...
September 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28922983/strategic-directions-in-immunoresponsive-biomaterials-in-tissue-engineering
#8
David Zaharoff, Christopher Jewell
Since its inception three to five decades ago (depending on who you ask), the field of tissue engineering has been inextricably linked with advances in biomaterials. Early developments in tissue engineering focused mainly on biocompatibility aspects. Natural and synthetic biomaterials were developed with a primary focus on maintaining cell viability prior to and shortly after the application or implantation of a seeded scaffold. Once a sufficient level of viability could be reproducibly achieved, the focus shifted to developing biomaterials with additional features, such as customized biodegradability and/or mechanical function...
September 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28922978/6-year-old-sheep-as-a-clinically-relevant-large-animal-model-for-aortic-valve-replacement-using-tissue-engineered-grafts-based-on-decellularized-allogenic-matrix
#9
Karolina Theodoridis, Igor Tudorache, Serghei Cebotari, Tanja Meyer, Alexandru Calistru, Samir Sarikouch, Cristoph Bara, Axel Haverich, Andres Hilfiker
Tissue-engineered (TE) grafts based on decellularized grafts have shown very promising results in preclinical and clinical studies. However, in animal models valves have either been tested in juvenile models or in the clinically less relevant pulmonary valve position. In this study, we tested the grafts in the aortic valve (AV) position of 6-year old sheep, as geriatric patients in need of an aortic valve substitute due to calcification are the largest patient group benefiting from TE grafts. Decellularized AV (n=4) and decellularized AV additionally re-endothelialized with autologous cells (n=3) were implanted in the aortic valve position of 6-year-old female sheep...
September 19, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28917628/an-engineered-biomarker-system-to-monitor-and-modulate-immune-clearance-of-cell-therapies
#10
Amy Singleton, Danika Khong, Ling-Yee Chin, Shilpaa Mukundan, Matthew Li, Biju Parekkadan
BACKGROUND AIMS: Cell transplants offer a new opportunity to deliver therapies with novel and complex mechanisms of action. Understanding the pharmacology of cell transplants is important to deliver this new therapy effectively. Currently, however, there are limited techniques to easily track cells after intravenous administration due to the dispersion of the graft throughout the entire body. METHODS: We herein developed an engineered cell system that secretes a luciferase enzyme to sensitively detect cell transplants independent of their locale by a simple blood test...
September 13, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28917095/turning-movements-vehicle-offsets-and-ageing-drivers-driving-behaviour-at-channelized-and-unchannelized-intersections
#11
Jaisung Choi, Richard Tay, Sangyoup Kim, Seungwon Jeong
Ageing drivers experience a higher risk of intersection crashes because of their decrease in driving efficiency, including the decline in cognitive ability, head and neck flexibility, and visual acuity. Although several studies have been conducted to examine the factors associated with ageing driver crashes at intersections, little research has been conducted to examine the differences in the factors related to ageing drivers' turning paths and intersection geometric features. This study aims to improve the safety of ageing drivers at intersections by identifying the maneuvers that are risky for them and tracking their turning movements at selected intersections...
September 13, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28915025/structural-evidence-for-the-dopamine-first-mechanism-of-norcoclaurine-synthase
#12
Benjamin R Lichman, Altin Sula, Thomas Pesnot, Helen C Hailes, John M Ward, Nicholas H Keep
Norcoclaurine synthase (NCS) is a Pictet-Spenglerase that catalyzes the first key step in plant benzylisoquinoline alkaloid metabolism, a compound family that includes bioactive natural products such as morphine. The enzyme has also shown great potential as a biocatalyst for the formation of chiral isoquinolines. Here we present new high-resolution X-ray crystallography data describing Thalictrum flavum NCS bound to a mechanism-inspired ligand. The structure supports two key features of the NCS "dopamine-first" mechanism: the binding of dopamine catechol to Lys-122 and the position of the carbonyl substrate binding site at the active site entrance...
September 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/28914948/nanotopography-mediated-osteogenic-differentiation-of-human-dental-pulp-derived-stem-cells
#13
Akash Bachhuka, Bahman Delalat, Soraya Rasi Ghaemi, Stan Gronthos, Nicolas H Voelcker, Krasimir Vasilev
Advanced medical devices, treatments and therapies demand an understanding of the role of interfacial properties on the cellular response. This is particularly important in the emerging fields of cell therapies and tissue regeneration. In this study, we evaluate the role of surface nanotopography on the fate of human dental pulp derived stem cells (hDPSC). These stem cells have attracted interest because of their capacity to differentiate to a range of useful lineages but are relatively easy to isolate. We generated and utilized density gradients of gold nanoparticles which allowed us to examine, on a single substrate, the influence of nanofeature density and size on stem cell behavior...
September 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28914914/regularized-huygens-plasmonic-wave-field-synthesis-using-a-metal-clad-plasmonic-waveguide-array
#14
Hyeonsoo Park, Joonsoo Kim, Youngjin Jeon, Byoungho Lee, Hwi Kim
Huygens' principle states that point sources are the basis of optical wave field generation, and an array of point sources with complex amplitudes that are separated by subwavelength distances can generate a desired optical field distribution. In field synthesis based on the Huygens' principle, the construction of ideal point sources has been overlooked when compared to other elements in optical field synthesis engineering, such as complex modulation. However, the construction of ideal point sources should be considered an important goal because the use of non-ideal point sources generates considerable optical noise in the background of the synthesized field distribution...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914533/m%C3%A3-ssbauer-spectroscopic-characterization-of-iron-iii-polysaccharide-coordination-complexes-photochemistry-biological-and-photoresponsive-materials-implications
#15
Hendrik Auerbach, Giuseppe E Giammanco, Volker Schünemann, Alexis D Ostrowski, Carl J Carrano
While polycarboxylates and hydroxyl-acid complexes have long been known to be photoactive, simple carboxylate complexes which lack a significant LMCT band are not typically strongly photoactive. Hence, it was somewhat surprising that a series of reports demonstrated that materials synthesized from iron(III) and polysaccharides such as alginate (poly[guluronan-co-mannuronan]) or pectate (poly[galacturonan]) formed photoresponsive materials that convert from hydrogels to sols under the influence of visible light...
September 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28910515/chiral-kagome-lattices-from-on-surface-synthesized-molecules
#16
Tao Wang, Qitang Fan, Lin Feng, Zhijie Tao, Jianmin Huang, Huanxin Ju, Qian Xu, Shanwei Hu, Junfa Zhu
Kagome lattices have attracted much attention due to their potential applications in spin-frustrated magnetism and host-guest chemistry. Examples toward the fabrication of 2D Kagome lattices reported previously have a common feature that the precursor molecules were typically structurally intact on surface with no chemical reactions accompanied. Herein, with the combined synchrotron radiation photoelectron spectroscopy (SRPES) and scanning tunneling microscopy (STM), we demonstrated that two types of chiral Kagome lattices from on-surface synthesized organometallic compounds were fabricated, which are known as intermediates of Glaser coupling on silver single crystal surfaces...
September 14, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28905379/a-new-species-of-pomatoschistus-teleostei-gobiidae-the%C3%A2-mediterranean-s-smallest-marine-fish
#17
S Engin, D Seyhan
The new sand goby species Pomatoschistus nanus (Teleostei: Gobiidae) is described from the northern coast of the Levantine Sea (eastern Mediterranean Sea) based on both morphological and DNA barcoding data. The new species is the smallest fish in the Mediterranean Sea and may be distinguished from congeners by the following features: predorsal area, first dorsal-fin base and breast naked; δ-pore missing; anterior point of the suborbital row b not reaching level of posterior point of suborbital row d; slightly emarginated caudal fin and nape coloration pattern...
September 14, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28904563/bacillus-coagulans-ma-13-a-promising-thermophilic-and-cellulolytic-strain-for-the-production-of-lactic-acid-from-lignocellulosic-hydrolysate
#18
Martina Aulitto, Salvatore Fusco, Simonetta Bartolucci, Carl Johan Franzén, Patrizia Contursi
BACKGROUND: The transition from a petroleum-based economy towards more sustainable bioprocesses for the production of fuels and chemicals (circular economy) is necessary to alleviate the impact of anthropic activities on the global ecosystem. Lignocellulosic biomass-derived sugars are suitable alternative feedstocks that can be fermented or biochemically converted to value-added products. An example is lactic acid, which is an essential chemical for the production of polylactic acid, a biodegradable bioplastic...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28903419/development-of-zebrafish-medulloblastoma-like-pnet-model-by-talen-mediated-somatic-gene-inactivation
#19
Jaegal Shim, Jung-Hwa Choi, Moon-Hak Park, Hyena Kim, Jong Hwan Kim, Seon-Young Kim, Dongwan Hong, Sunshin Kim, Ji Eun Lee, Cheol-Hee Kim, Jeong-Soo Lee, Young-Ki Bae
Genetically engineered animal tumor models have traditionally been generated by the gain of single or multiple oncogenes or the loss of tumor suppressor genes; however, the development of live animal models has been difficult given that cancer phenotypes are generally induced by somatic mutation rather than by germline genetic inactivation. In this study, we developed somatically mutated tumor models using TALEN-mediated somatic gene inactivation of cdkn2a/b or rb1 tumor suppressor genes in zebrafish. One-cell stage injection of cdkn2a/b-TALEN mRNA resulted in malignant peripheral nerve sheath tumors with high frequency (about 39%) and early onset (about 35 weeks of age) in F0 tp53(e7/e7) mutant zebrafish...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902981/layer-structured-materials-for-advanced-energy-storage-and-conversion
#20
REVIEW
Yanpeng Guo, Yaqing Wei, Huiqiao Li, Tianyou Zhai
Owing to the strong in-plane chemical bonds and weak van der Waals force between adjacent layers, investigations of layer structured materials have long been the hotspots in energy-related fields. The intrinsic large interlayer space endows them capabilities of guest ion intercalation, fast ion diffusion, and swift charge transfer along the channels. Meanwhile, the well-maintained in-plane integrity contributes to exceptional mechanical properties. This anisotropic structural feature is also conducive to effective chemical combination, exfoliation, or self-assembly into various nanoarchitectures, accompanied by the introduction of defects, lattice strains, and phase transformation...
September 13, 2017: Small
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