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https://www.readbyqxmd.com/read/29332614/serelaxin-for-infant-heart-failure-in-congenital-dilated-cardiomyopathy
#1
Patrick O Myers, Alice Bordessoule, Cécile Tissot
Serelaxin has been studied in trials in adults with acute heart failure, but not in children. We report the first compassionate use of serelaxin in an infant. A 6-month-old girl with dilated cardiomyopathy was placed on extracorporeal membrane oxygenation following cardiac arrest unresponsive to medical treatment. Extracorporeal membrane oxygenation weaning failed despite maximal ino-dilator therapy. During the 48-hour infusion of serelaxin, we observed marked improvement in brain natriuretic peptide, left ventricular systolic function, and dilatation...
January 15, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29301403/improving-mandatory-vaccination-against-influenza-minimizing-anxiety-of-employees-to-maximize-health-of-patients
#2
Andrea L Benin, Gina Lockwood, Tracy Creatore, Donna Donovan, Maggi Predmore, Susan MacArthur
The objective was to describe qualitatively the attitudes among employees toward mandatory vaccination against influenza to ultimately improve such programs and prevent hospital-acquired influenza. Qualitative interviews were conducted with 21 employees at a freestanding children's hospital. Analysis of interview transcripts used grounded theory and the constant comparative method; codes were iteratively revised and refined as themes emerged. Themes emerged elucidating promoters and concerns. Promoters included a desire to protect self, family, and patients; perception of vaccination as part of professional responsibility; and free vaccination as a benefit from the organization...
December 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29290209/self-compassion-physical-fitness-and-climacteric-symptoms-in-oophorectomized-brca1-2-mutation-carriers
#3
Marieke Arts-de Jong, Liselore L van Westerop, Nicoline Hoogerbrugge, Leon F Massuger, Angela H Maas, Maria H van Beek, Joanne A de Hullu
OBJECTIVES: To reduce the risk of ovarian cancer, BRCA1/2 mutation carriers are advised to undergo salpingo-oophorectomy (RRSO) around the age of 40 years. This may induce severe climacteric symptoms, potentially lowering their quality of life. Personal positive resources such as physical fitness and self-compassion may help women to deal with these symptoms. We investigated the association of climacteric symptoms with self-compassion and physical fitness in oophorectomized BRCA1/2 mutation carriers...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29287803/transcriptional-profile-of-in-vitro-expanded-human-epidermal-progenitor-cells-for-the-treatment-of-non-healing-wounds
#4
Paulina Langa, Anna Wardowska, Jacek Zieliński, Justyna Podolak-Popinigis, Piotr Sass, Paweł Sosnowski, Karolina Kondej, Alicja Renkielska, Paweł Sachadyn, Piotr Trzonkowski, Michał Pikuła
BACKGROUND: Epidermal progenitor cells (EPCs) have been under extensive investigation due to their increasing potential of application in medicine and biotechnology. Cultured human EPCs are used in the treatment of chronic wounds and have recently became a target for gene therapy and toxicological studies. One of the challenges in EPCs culture is to provide a high number of undifferentiated, progenitor cells displaying high viability and significant biological activity. OBJECTIVES: The goal of this study was to characterize the in vitro cultured progenitor cells and to assess whether the cells with the progenitor phenotype are able to enhance wound healing...
December 13, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29283868/a-review-of-the-essential-components-of-quality-palliative-care-in-the-home
#5
Hsien Seow, Daryl Bainbridge
OBJECTIVE: The home is an important and often preferable setting of palliative care. While much research has demonstrated the benefits of specialized palliative homecare on patient and system outcomes, there has been little delineation of the underlying components of these efficacious programs. We synthesized the essential elements of palliative homecare from a combined review of successful programs, perspectives of patients and caregivers, and views of healthcare providers in palliative care...
January 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29280298/emotions-as-student-feedback
#6
Karin Belch, Susan Law
BACKGROUND: Student feedback is often sought by educators in order to inform future developments in teaching or curriculum development. A lack of engagement with current feedback tools is thought, partly, to result from students perceiving no gain from the activity. The emotional adjective feedback tool (EAFT) is designed around the concept of emotional intelligence, where students feed back to tutors, after clinical teaching, by selecting and elaborating on emotional adjectives that describe their learning experiences...
December 26, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/29250865/measuring-health-care-workers-perceptions-of-what-constitutes-a-compassionate-organisation-culture-and-working-environment-findings-from-a-quantitative-feasibility-survey
#7
Robert McSherry, Paddy Pearce
INTRODUCTION: Health care organisation cultures and working environments are highly complex, dynamic and constantly evolving settings. They significantly influence both the delivery and outcomes of care. AIM: Phase 1 quantitative findings are presented from a larger three phase feasibility study designed to develop and test a Cultural Health Check toolkit to support health care workers, patients and organisations in the provision of safe, compassionate and dignified care...
December 17, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/29244046/humor-a-rehabilitative-tool-in-the-post-intensive-care-of-young-adults-with-acquired-brain-injury
#8
Kate O'Reilly
PURPOSE: The aim of the study was to describe how paid carers use humor in providing compassionate post-intensive rehabilitation care to young adults with acquired brain injury (ABI) who are unable to perform or direct their own care. DESIGN: This is a qualitative study underpinned by symbolic interactionism. METHODS: Paid carers in a residential aged care facility were interviewed. Interview data were analyzed using grounded theory methods of coding, comparative analysis, memoing, and theoretical sampling...
July 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29241828/acute-and-chronic-rapamycin-use-in-patients-with-fibrodysplasia-ossificans-progressiva-a-report-of-two-cases
#9
REVIEW
Frederick S Kaplan, Leonid Zeitlin, Stephen P Dunn, Shira Benor, David Hagin, Mona Al Mukaddam, Robert J Pignolo
Fibrodysplasia Ossificans Progressiva (FOP) is an ultrarare genetic disorder of progressive, disabling heterotopic ossification for which there is presently no definitive treatment. Several recent studies in genetic mouse models of FOP support involvement of the mechanistic target of rapamycin complex 1 (mTORC1) pathway in the pathophysiology of FOP and propose the repurposed use of rapamycin, an inhibitor of mTORC1 signaling in clinical trials for the management of FOP. Here we report two patients with the classic FOP mutation who received rapamycin-one for four months on a compassionate basis for treatment of acute flare-ups of the neck and back that were refractory to corticosteroid therapy-and the other for 18years for chronic immunosuppression following liver transplantation for intercurrent cytomegalovirus infection...
December 11, 2017: Bone
https://www.readbyqxmd.com/read/29240907/primary-care-for-refugees-and-newly-arrived-migrants-in-europe-a-qualitative-study-on-health-needs-barriers-and-wishes
#10
Tessa van Loenen, Maria van den Muijsenbergh, Marrigje Hofmeester, Christopher Dowrick, Nadja van Ginneken, Enkeleint Aggelos Mechili, Agapi Angelaki, Dean Ajdukovic, Helena Bakic, Danica Rotar Pavlic, Erika Zelko, Kathryn Hoffmann, Elena Jirovsky, Elisabeth Sophie Mayrhuber, Michel Dückers, Trudy Mooren, Juul Gouweloos-Trines, László Kolozsvári, Imre Rurik, Christos Lionis
Background: In order to provide effective primary care for refugees and to develop interventions tailored to them, we must know their needs. Little is known of the health needs and experiences of recently arrived refugees and other migrants throughout their journey through Europe. We aimed to gain insight into their health needs, barriers in access and wishes regarding primary health care. Methods: In the spring of 2016, we conducted a qualitative, comparative case study in seven EU countries in a centre of first arrival, two transit centres, two intermediate-stay centres and two longer-stay centres using a Participatory Learning and Action research methodology...
December 12, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29240024/delayed-methotrexate-clearance-despite-carboxypeptidase-g2-glucarpidase-administration-in-2-patients-with-toxic-methotrexate-levels
#11
Kirk D Wyatt, Jeffrey Cooper, Katherine Scott, Eileen Broomall, Sadaf Altaf, Marie C Hogan, Vilmarie Rodriguez, Shakila Khan
High-dose methotrexate has been a treatment for osteosarcoma; however, its nephrotoxic effects are considerable. Carboxypeptidase-G2 (glucarpidase) was approved by the US Food and Drug Administration in 2012 for treatment of toxic methotrexate levels. We report our experience using glucarpidase under compassionate use before Food and Drug Administration approval in 2 patients who had delayed methotrexate clearance and prolonged kidney injury despite glucarpidase administration. Our results show that patients with methotrexate toxicity may require repeated doses of glucarpidase in addition to supportive measures, such as dialysis...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29228783/training-in-integrative-therapies-increases-self-efficacy-in-providing-nondrug-therapies-and-self-confidence-in-offering-compassionate-care
#12
Kathi J Kemper, Ellie Hill
BACKGROUND: Patient demand and clinician interest have driven professional training in integrative therapies, but few rigorous evaluations have been published. METHODS: This project evaluated the proof of concept of training in acupressure, guided imagery, massage, and Reiki on clinicians' sense of self-efficacy in providing nondrug therapies, self-confidence in providing compassionate care, and engagement with work. RESULTS: Three out of 4 topics met minimum enrollment numbers; 22 of 24 participants completed follow-up as well as pretraining surveys...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29226591/validating-a-prediction-modeling-tool-for-left-ventricular-outflow-tract-lvot-obstruction-after-transcatheter-mitral-valve-replacement-tmvr
#13
Dee Dee Wang, Marvin H Eng, Adam B Greenbaum, Eric Myers, Michael Forbes, Patrick Karabon, Milan Pantelic, Thomas Song, Jeff Nadig, Mayra Guerrero, William W O'Neill
OBJECTIVE: Demonstrate proof-of-concept validation of a computed tomography (CT) computer-aided design prediction modeling tool to identify patients at risk for left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a significant and even fatal consequence of TMVR. METHODS: From August 2013 to August 2017, 38 patients in 5 centers underwent TMVR with compassionate use of balloon-expandable valves for severe mitral valve dysfunction because of degenerative surgical mitral ring, bioprosthesis, or severe native mitral stenosis from to severe mitral annular calcification...
December 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29220625/feasibility-of-training-and-delivering-compassionate-touch-in-long-term-care
#14
Areum Han, Mark E Kunik
OBJECTIVES: Limited evidence supports the use of therapeutic touch for people with dementia (PWD). Interventions incorporating a person-centered approach to touch delivered by staff may benefit PWD and staff in long-term care settings. The Compassionate Touch® (CT) program provides skilled human touch and a compassionate presence following a person-centered approach and touch protocol. The purpose of this study was to determine the feasibility of training and delivering CT. METHODS: An online survey was sent via email to 112 staff who attended the CT coach training...
September 19, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29214963/ideology-and-palliative-care-moral-hazards-at-the-bedside
#15
Rosamond Rhodes, James J Strain
Palliative care has had a long-standing commitment to teaching medical students and other medical professionals about pain management, communication, supporting patients in their decisions, and providing compassionate end-of-life care. Palliative care programs also have a critical role in helping patients understand medical conditions, and in supporting them in dealing with pain, fear of dying, and the experiences of the terminal phase of their lives. We applaud their efforts to provide that critical training and fully support their continued important work in meeting the needs of patients and families...
January 2018: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/29214116/compassionate-use-of-ruxolitinib-in-acute-and-chronic-graft-versus-host-disease-refractory-both-to-corticosteroids-and-extracorporeal-photopheresis
#16
Mauricio Sarmiento Maldonado, Pablo Ramírez Villanueva, Pablo Bertín Cortes-Monroy, Veronica Jara Arias, Katherine Soto Donoso, Pablo Uribe Gonzalez, Mauricio Ocqueteau Tachini, Jose Antonio Perez-Simón
Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation: In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29212641/incivility-and-professional-comportment-in-critical-care-nurses
#17
Kenneth John Oja
BACKGROUND: Civility among critical care nurses is important for achieving positive patient outcomes. Professional comportment refers to nurse behaviors that are respectful, knowledgeable, deliberate, and compassionate. OBJECTIVE: To examine the relationship between perceptions of nurse-to-nurse incivility and professional comportment among critical care nurses, and the extent to which nurse characteristics influence their perceptions. METHODS: Data were collected from nurses in 14 critical care units...
2017: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/29204933/feasibility-and-effectiveness-of-trifluridine-tipiracil-in-metastatic-colorectal-cancer-real-life-data-from-the-netherlands
#18
Johannes J M Kwakman, G Vink, J H Vestjens, L V Beerepoot, J W de Groot, R L Jansen, F L Opdam, H Boot, G J Creemers, J M van Rooijen, M Los, A J E Vulink, H Schut, E van Meerten, A Baars, P Hamberg, E Kapiteijn, D W Sommeijer, C J A Punt, M Koopman
BACKGROUND: The RECOURSE trial showed clinical efficacy for trifluridine/tipiracil for refractory metastatic colorectal cancer patients. We assessed the feasibility and effectiveness of trifluridine/tipiracil in daily clinical practice in The Netherlands. METHODS: Medical records of patients from 17 centers treated in the trifluridine/tipiracil compassionate use program were reviewed and checked for RECOURSE eligibility criteria. Baseline characteristics, safety, and survival times were compared, and prespecified baseline characteristics were tested in multivariate analyses for prognostic significance on overall survival (OS)...
December 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29202158/therapeutic-value-of-medical-marijuana-in-new-jersey-patients-a-community-partnership-research-endeavor
#19
Tara L Crowell
OBJECTIVE: The Public Health Program at Stockton University partnered with the Compassionate Care Foundation to ascertain the impact of medical marijuana on patients in New Jersey. METHODS: Patients volunteered to complete a survey once a month for 8 months. The survey explored their use, form, and strain of medical marijuana and its influence on pain and 12 other physical and mental health variables. Also, an increase or decrease in other medication taken and any unexpected outcomes were recorded...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/29200050/a-call-for-compassionate-care
#20
Karen Alexander
The Substance Abuse and Mental Health Services Administration (2014) reported that 1.1% of pregnant women used nonprescription opiates (either heroin or prescription pills) in the last 30 days. Methadone and buprenorphine are the most common treatments for opiate addiction in pregnant women. Reasons for seeking opiate maintenance treatment (OMT) include keeping custody of one's children and the hope of developing a healthy parenting relationship. Yet, healthcare organizations and professionals have mixed opinions regarding health promotion within the maternal OMT population...
October 2017: Journal of Addictions Nursing
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