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Compassionate use

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https://www.readbyqxmd.com/read/29151269/how-to-practice-person-centred-care-a-conceptual-framework
#1
REVIEW
Maria J Santana, Kimberly Manalili, Rachel J Jolley, Sandra Zelinsky, Hude Quan, Mingshan Lu
BACKGROUND: Globally, health-care systems and organizations are looking to improve health system performance through the implementation of a person-centred care (PCC) model. While numerous conceptual frameworks for PCC exist, a gap remains in practical guidance on PCC implementation. METHODS: Based on a narrative review of the PCC literature, a generic conceptual framework was developed in collaboration with a patient partner, which synthesizes evidence, recommendations and best practice from existing frameworks and implementation case studies...
November 19, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29149520/compassion-in-practice-evaluating-the-awareness-involvement-and-perceived-impact-of-a-national-nursing-and-midwifery-strategy-amongst-health-care-professionals-in-nhs-trusts-in-england
#2
Helen Allan, Mike O'Driscoll, Liang Liu, Kevin Corbett, Laura Serrant
AIM: To report the findings from an evaluation of the impact of the Compassion in Practice Vision & Strategy (CiPVS) (National Health Service England (NHSE), 2012) on nursing, midwifery and care staff. BACKGROUND: The CiPVS was a programme of work to highlight the importance of compassionate care following the Francis Report in 2013 into the deficits in care in an NHS hospital trust. It was launched by NHS England in 2012 at a time when fiscal cuts were introduced by the Department of Health in England...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29146571/using-schwartz-center-rounds-to-promote-compassionate-care-in-a-children-s-hospital
#3
Jan Hughes, Alistair J Duff, John W L Puntis
No abstract text is available yet for this article.
November 16, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29144995/content-analysis-of-homeless-smokers-perspectives-on-established-and-alternative-smoking-interventions
#4
Susan E Collins, Victoria E Orfaly, Teresa Wu, Sunny Chang, Robert V Hardy, Amia Nash, Matthew B Jones, Leslie Mares, Emily M Taylor, Lonnie A Nelson, Seema L Clifasefi
BACKGROUND: Cigarette smoking is 5 times more prevalent among homeless individuals than in the general population, and homeless individuals are disproportionately affected by smoking-related morbidity and mortality. Homeless smokers report interest in changing their smoking behavior; however, established smoking cessation interventions are neither desirable to nor highly effective for most members of this population. The aim of this study was to document homeless smokers' perceptions of established smoking interventions as well as self-generated, alternative smoking interventions to elucidate points for intervention enhancement...
November 13, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29135281/ceritinib-compassionate-use-for-patients-with-crizotinib-refractory-anaplastic-lymphoma-kinase-positive-advanced-non-small-cell-lung-cancer
#5
Giulio Metro, Antonio Passaro, Giuseppe Lo Russo, Laura Bonanno, Raffaele Giusti, Vanesa Gregorc, Enrica Capelletto, Olga Martelli, Fabiana L Cecere, Diana Giannarelli, Andrea Luciani, Alessandra Bearz, Alessandro Tuzi, Vieri Scotti, Giuseppe Tonini, Domenico Galetta, Annamaria Carta, Hector Soto Parra, Alberto Rebonato, Alessandro Morabito, Rita Chiari
AIM: Ceritinib was evaluated within a compassionate use program of Italian patients. PATIENTS & METHODS: 70 patients with anaplastic lymphoma kinase-positive crizotinib-refractory advanced non-small-cell lung cancer received ceritinib. RESULTS: Overall response was 40.6%, median progression-free survival was 8.2 months and median survival was 15.5 months. Dose reduction due to treatment-related adverse events occurred in 50.8% of patients starting at 750 mg/day...
November 14, 2017: Future Oncology
https://www.readbyqxmd.com/read/29134851/perceptions-and-uses-of-public-and-private-health-care-in-a-brazilian-favela
#6
Débora Castiglione, Gina S Lovasi, Marilia S Carvalho
Since 1988, Brazil has reorganized and expanded its public health care system, defining access to health care as a right of every citizen. In parallel, the private health care sector grew rapidly to become one of the largest in the world. We explore the use of public and private health care by a low-income population living in a favela, Rio das Pedras, in Rio de Janeiro. At the time of data collection, only part of the community was covered by the primary health care program. We conducted semistructured interviews with 14 adults, both with and without access to the public primary care program...
November 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29134648/pharmacokinetics-pharmacodynamics-and-proposed-dosing-of-the-oral-jak1-and-jak2-inhibitor-baricitinib-in-pediatric-and-young-adult-candle-and-savi-patients
#7
Hanna Kim, Kristina M Brooks, Cheng Cai Tang, Paul Wakim, Mary Blake, Stephen R Brooks, Gina A Montealegre Sanchez, Adriana A de Jesus, Yan Huang, Wanxia Li Tsai, Massimo Gadina, Apurva Prakash, Jonathan Marcus Janes, Xin Zhang, William L Macias, Parag Kumar, Raphaela Goldbach-Mansky
Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of the oral janus kinase (JAK)1/JAK2 inhibitor, baricitinib, in 18 patients with Mendelian interferonopathies who are enrolled in a compassionate use program. Patients received doses between 0.1 to 17 mg per day. Covariates of weight and renal function significantly influenced volume-of-distribution and clearance respectively. The half-life of baricitinib in patients less than 40kg was substantially shorter than in adult populations, requiring the need for dosing up to 4 times daily...
November 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29132018/the-provision-of-accredited-higher-education-on-dementia-in-six-european-countries-an-exploratory-study
#8
Simona Hvalič-Touzery, Brigita Skela-Savič, Rhoda Macrae, Anna Jack-Waugh, Debbie Tolson, Amanda Hellström, Wilson de Abreu, Katja Pesjak
BACKGROUND: The World Health Organization has identified developing the knowledge and skills of healthcare professionals who are involved in dementia care as a priority. Most healthcare professionals lack the necessary knowledge, skills and understanding to provide high quality dementia care. While dementia education amongst most UK university health and social care programmes is inconsistent, we know little about the provision of dementia education in European universities. OBJECTIVES: To examine the provision of accredited higher education on dementia in European countries, to illustrate that it is highly variable despite universities being the major provider of education for healthcare professionals internationally...
November 6, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29126225/bedaquiline-resistance-its-emergence-mechanism-and-prevention
#9
Thi Van Anh Nguyen, Richard M Anthony, Anne-Laure Bañuls, Dinh Hoa Vu, Jan-Willem C Alffenaar
Bedaquiline, a new anti-tuberculosis drug, has already been used in more than 50 countries. The emergence of bedaquiline resistance is alarming, as it may result in the rapid loss of this new drug. This paper aims to review currently identified mechanisms of resistance, the emergence of bedaquiline resistance, and discuss strategies to delay the resistance acquisition. In vitro and clinical studies as well as reports from the compassionate use have identified the threat of bedaquiline resistance and cross-resistance with clofazimine, emphasizing the crucial need for the systematic surveillance of resistance...
November 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29119440/compassionate-use-of-bacteriophage-therapy-for-foot-ulcer-treatment-as-an-effective-step-for-moving-toward-clinical-trials
#10
Randolph Fish, Elizabeth Kutter, Gordon Wheat, Bob Blasdel, Mzia Kutateladze, Sarah Kuhl
We here present detailed descriptions of successful treatment of a series of diabetic toe ulcers using the Eliava BioPreparations' commercial preparation of the very well-studied anti-staphylococcal bacteriophage Sb-1. This chapter outlines what we feel is an appropriate mechanism to speed movement toward full-scale clinical trials with bacteriophage use to treat wound infections and to help address the crisis in antibiotic resistance.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29116676/salvage-therapy-with-topical-posaconazole-in-lung-transplant-recipients-with-invasive-scedosporium-infection
#11
Amparo Solé, Ana A García-Robles, Carlos Jordá, Enrique Cases Viedma, Nuria Mancheño, José Luis Poveda-Andrés, Juan Pablo Reig Mezquida, Javier Pemán
Scedosporium is an important pathogen in cystic fibrosis (CF) and post-transplant, but it rarely causes invasive infection. Treatment remains challenging, particularly due to the inherent resistance to multiple antifungal agents. We present three complicated invasive tracheobronchial and lung Scedosporium apiospermum infections following lung transplant. In two of three cases, the infection was clinically and radiologically cured with frequent cleansing bronchoscopies, combining triazole with terbinafine therapy and nebulized posaconazole...
November 8, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29106929/gentamicin-induced-readthrough-and-nonsense-mediated-mrna-decay-of-serpinb7-nonsense-mutant-transcripts
#12
Yuka Ohguchi, Toshifumi Nomura, Shotaro Suzuki, Masae Takeda, Toshinari Miyauchi, Osamu Mizuno, Satoru Shinkuma, Yasuyuki Fujita, Osamu Nemoto, Kota Ono, W H Irwin McLean, Hiroshi Shimizu
Nagashima-type palmoplantar keratosis (NPPK) is an autosomal recessive skin disorder with a high, unmet medical need that is caused by mutations in SERPINB7. Almost all NPPK patients carry the founder nonsense mutation c.796C>T (p.Arg266Ter) in the last exon of SERPINB7. Here we sought to determine whether topical "nonsense-suppression (readthrough)" therapy using gentamicin is applicable to NPPK. First, we demonstrated that gentamicin enhanced readthrough activity in cells transfected with SERPINB7 cDNA carrying the mutation and promoted full-length SERPINB7 protein synthesis in NPPK keratinocytes...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29096116/courage-to-care-for-our-united-states-veterans-a-constructivist-way-of-teaching-and-learning-for-future-nurses
#13
Edna R Magpantay-Monroe
The knowledge and skills in providing veteran centered care is essential. The purpose of this retrospective evaluation is to examine a faculty's reflections on a BSN psychiatric mental health curriculum initiative that provides knowledge and skills regarding veterans care through several avenues to senior nursing students. This qualitative study use self-reflections through a constructivist view of teaching and learning as the framework. Open discussions in didactic about the unique psychological health issues of veterans formed a foundational knowledge for the students...
October 20, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29081924/proposed-changes-to-the-reimbursement-of-pharmaceuticals-and-medical-devices-in-poland-and-their-impact-on-market-access-and-the-pharmaceutical-industry
#14
Karolina Badora, Aleksandra Caban, Cécile Rémuzat, Claude Dussart, Mondher Toumi
In Poland, two proposed amendments to the reimbursement act are currently in preparation; these are likely to substantially change the pricing and reimbursement landscape for both drugs and medical devices. Proposed changes include: alignment of medical device reimbursement with that of pharmaceuticals; relaxing the strict reimbursement criteria for ultra-orphan drugs; establishment of an additional funding category for vaccines; introduction of compassionate use, and a simplified reimbursement pathway for well-established off-label indications; appreciation of manufacturers' innovation and research and development efforts by creating a dedicated innovation budget; introduction of a mechanism preventing excessive parallel import; prolonged duration of reimbursement decisions and reimbursement lists; and increased flexibility in defining drug programmes...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29075064/role-of-arsenic-trioxide-in-the-management-of-aplastic-anemia
#15
Gaurav Prakash, Uday Yanamandra, Alka Khadwal, Neelam Varma, Subhash Varma, Pankaj Malhotra
Aplastic anemia is a common problem in the developing world with therapeutic challenges as most of the patients are non-affording to standard care owing to resource constraints. We present the results of an open label single arm, non-randomized, single center, prospective phase II trial of the compassionate use of arsenic trioxide in patients refractory to ATG or unable to afford the standard of care therapy. The study was prematurely terminated at eighth week due to non-response in 100% of patients and death in two patients...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29065835/hydroxypropyl-%C3%AE-cyclodextrin-formulated-in-nasal-chitosan-microspheres-as-candidate-therapeutic-agent-in-alzheimer-s-disease
#16
Giovanna Rassu, Elisabetta Gavini, Antonio Carta, Antonella Obinu, Elena Piera Porcu, Paolo Giunchedi
Hydroxypropyl-β-cyclodextrin (HP-CD) is a hydroxyalkyl derivative of native β-cyclodextrin, cyclic oligosaccharide able to form inclusion complexes with many drugs and biomolecules [1]. Cyclodextrins have a possible neuroprotective effect due to their capability to extract and deplete cholesterol from cell membranes [1]. HP-CD is classified as an excipient (cyclodextrins are in fact widely used to improve solubility of poorly water soluble drugs) and it is not been FDA-approved as therapeutic agent. However HP-CD received the "orphan drug designation" in the United States and Europe because it is employed in individual compassionate use for patients suffering from Niemann-Pick type C...
October 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29064289/the-paradox-of-compassionate-work-a-mixed-methods-study-of-satisfying-and-fatiguing-experiences-of-animal-health-care-providers
#17
Alicia J Polachek, Jean E Wallace
BACKGROUND AND OBJECTIVES: Compassionate work appears paradoxical as it may provide great rewards, but may also come at great costs to care providers. This paper explores the paradox of compassionate work by examining what interactions contribute to compassion satisfaction and what interactions contribute to compassion fatigue. DESIGN: This mixed-methods, cross-sectional study uses qualitative interview data from animal health care providers (N = 20) to identify work interactions that they find satisfying or stressful...
October 24, 2017: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/29053386/promoting-health-from-the-pulpit-a-process-evaluation-of-hiv-sermons-to-reduce-hiv-stigma-and-promote-testing-in-african-american-and-latino-churches
#18
Denise D Payán, Karen R Flórez, Laura M Bogart, David E Kanouse, Michael A Mata, Clyde W Oden, Kathryn P Derose
Embedding health messages into sermons is a potentially valuable strategy to address HIV and other health disparities in churches that predominantly serve racial and ethnic minorities. This study explores implementation of an HIV sermon as part of a multi-component intervention in three churches (Latino Catholic, Latino Pentecostal, and African American Baptist) in high HIV prevalence areas of Los Angeles County, California. Clergy were given an HIV sermon guide that included local public health data, stigma reduction cues, HIV testing messages, and a sample sermon...
October 20, 2017: Health Communication
https://www.readbyqxmd.com/read/29044920/co-responding-police-mental-health-programmes-service-user-experiences-and-outcomes-in-a-large-urban-centre
#19
Denise Lamanna, Gilla K Shapiro, Maritt Kirst, Flora I Matheson, Arash Nakhost, Vicky Stergiopoulos
As police officers are often the first responders to mental health crises, a number of approaches have emerged to support skilled police crisis responses. One such approach is the police-mental health co-responding team model, whereby mental health nurses and police officers jointly respond to mental health crises in the community. In the present mixed-method study, we evaluated outcomes of co-responding team interactions at a large Canadian urban centre by analysing administrative data for 2743 such interactions, and where comparison data were available, compared them to 16 226 police-only team responses...
October 17, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29040994/sorafenib-regorafenib-sequential-therapy-in-advanced-hepatocellular-carcinoma-a-single-institute-experience
#20
Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo
OBJECTIVES: Previously, no therapeutic agent has been known to improve the overall survival compared with placebo in patients with hepatocellular carcinoma (HCC), who have progressed after sorafenib. In this patient population, regorafenib was first demonstrated to confer a survival benefit in the RESORCE trial, and subsequently it was approved as a second-line treatment for patients with advanced HCC. An open-label expanded access program (EAP) of regorafenib was implemented for compassionate use...
2017: Digestive Diseases
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