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https://www.readbyqxmd.com/read/28922141/towards-an-in-plane-methodology-to-track-breast-lesions-by-using-mammograms-and-patient-specific-finite-element-simulations
#1
Andres Lapuebla-Ferri, Jose Cegoñino-Banzo, Antonio-Jose Jimenez-Mocholi, Amaya Perez Del Palomar
In breast cancer screening or diagnosis, it is usual to combine different images in order to locate a lesion as accurately as possible. These images are generated by using a single or several imaging techniques. As X-ray based mammography is used widespread, a breast lesion is located in the same plane of the image (mammogram), but tracking of a breast lesion across mammograms corresponding to different views is a daring task for medical physicians. According to this, simulation tools and methodologies that use patient-specific numerical models can facilitate the task of fusing information from different images...
September 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28921612/systematic-review-and-meta-analysis-of-non-pharmacological-interventions-to-reduce-the-symptoms-of-mild-to-moderate-anxiety-in-pregnant-women
#2
REVIEW
Kerry Evans, C Jane Morrell, Helen Spiby
AIM: To assess the effectiveness of non-pharmacological interventions for pregnant women with symptoms of mild to moderate anxiety. BACKGROUND: Many pregnant women experience mild to moderate symptoms of anxiety and could benefit from additional support. Non-pharmacological interventions have been suggested for use during pregnancy. DESIGN: A systematic review of randomised controlled trials. DATA SOURCES: Randomised controlled trials published since 1990, identified from electronic databases: Medline; CINAHL; Maternity and Infant Care; PsycINFO; Cochrane Database of Systematic Reviews; CENTRAL; EMBASE; Centre for Reviews and Dissemination; Social Sciences Citation Index; ASSIA; HTA Library; Joanna Briggs Institute Evidence-Based Practice database; Allied and Complementary Medicine...
September 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28921528/practitioner-review-treatment-of-chronic-insomnia-in-children-and-adolescents-with-neurodevelopmental-disabilities
#3
REVIEW
Oliviero Bruni, Marco Angriman, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Samuele Cortese, Raffaele Ferri
BACKGROUND: Sleep disturbances, in particular insomnia, represent a common problem in children with neurodevelopmental disabilities (NDDs). Currently, there are no approved medications for insomnia in children by the US Food and Drug Administration or European Medicines Agency and therefore they are prescribed off-label. We critically reviewed pediatric literature on drugs as well as nonpharmacological (behavioral) interventions used for sleep disturbances in children with NDDs. METHODS: PubMed, Ovid (including PsycINFO, Ovid MEDLINE(®) , and Embase), and Web of Knowledge databases were searched through February 12, 2017, with no language restrictions...
September 18, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28920533/refinement-of-the-montreal-instrument-for-cat-arthritis-testing-for-use-by-veterinarians-detection-of-naturally-occurring-osteoarthritis-in-laboratory-cats
#4
Mary P Klinck, Beatriz P Monteiro, Bertrand Lussier, Martin Guillot, Maxim Moreau, Colombe Otis, Paulo Vm Steagall, Diane Frank, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Jérôme Re Del Castillo, Eric Troncy
Objectives Feline osteoarthritis causes pain and disability. Detection and measurement is challenging, relying heavily on owner report. This study describes refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians. Methods A video analysis of osteoarthritic (n = 6) and non-osteoarthritic (n = 4) cats facilitated expansion of scale items. Three successive therapeutic trials (using gabapentin, tramadol and oral transmucosal meloxicam spray) in laboratory cats with and without natural osteoarthritis (n = 12-20), permitted construct validation (assessments of disease status sensitivity and therapeutic responsiveness) and further scale refinements based on performance...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28920057/amine-metabolism-is-influenced-by-dietary-protein-source
#5
Soumya K Kar, Alfons J M Jansman, Dirkjan Schokker, Leo Kruijt, Amy C Harms, Jerry M Wells, Mari A Smits
Growth in world population will inevitably leads to increased demand for protein for humans and animals. Protein from insects and blood plasma are being considered as possible alternatives, but more research on their nutritional quality and health effects is needed. Here, we studied the effect of dietary protein source on metabolism and metabolic amine profiles in serum and urine of mice. Groups of mice were fed semi-purified diets containing 300 g/kg of soybean meal, casein, partially delactosed whey powder, spray-dried plasma protein, wheat gluten meal, and yellow mealworm...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28919497/body-mass-index-predicts-selected-physical-fitness-attributes-but-is-not-associated-with-performance-on-military-relevant-tasks-in-u-s-army-soldiers
#6
Joseph R Pierce, David W DeGroot, Tyson L Grier, Keith G Hauret, Bradley C Nindl, Whitfield B East, Michael S McGurk, Bruce H Jones
OBJECTIVES: Army body composition standards are based upon validated criteria; however, certain field-expedient methodologies (e.g., weight-for-height, body mass index [BMI]) may disqualify individuals from service who may otherwise excel on physical performance and military-relevant tasks. The purpose was to assess soldier physical performance and military-specific task/fitness performance stratified by BMI. DESIGN: Cross-sectional observational study. METHODS: Male (n=275) and female (n=46) soldiers performed a wide-array of physical fitness tests and military-specific tasks, including the Army physical fitness test (APFT)...
September 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28919394/concomitant-chemotherapy-and-radiotherapy-with-sbrt-boost-for-unresectable-stage-iii-non-small-cell-lung-cancer-a-phase-i-study
#7
Kristin A Higgins, Rathi N Pillai, Zhengjia Chen, Sibo Tian, Chao Zhang, Pretesh Patel, Suchita Pakkala, Jay Shelton, Seth D Force, Felix G Fernandez, Conor E Steuer, Taofeek K Owonikoko, Suresh S Ramalingam, Jeffrey D Bradley, Walter J Curran
PURPOSE: Stereotactic Body Radiation Therapy (SBRT) is now the standard of care in medically inoperable stage I non-small cell lung cancer, yielding high rates of local control. It is unknown if SBRT can be safely utilized in the locally advanced NSCLC setting. This multi-institution phase I study evaluated the safety of 44 Gy conventionally fractionated thoracic radiation with concurrent chemotherapy plus a dose escalated SBRT boost to both the primary tumor and involved mediastinal lymph nodes...
September 12, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28918114/netrins-semaphorins-novel-regulators-of-the-immune-response
#8
REVIEW
Jordyn Feinstein, Bhama Ramkhelawon
Netrins and semaphorins, members of the neuronal guidance cue family, exhibit a rich biology with significant roles that extend beyond chemotactic guidance of the axons to build the neuronal patterns of the body. Screening of adult tissues and specific cellular subsets have illuminated that these proteins are also abundantly expressed under both steady state and pathological scenarios. This observation suggests that, in addition to their role in the development of the axonal tree, these proteins possess additional novel functions in adult physiopathology...
September 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#9
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. STUDY DESIGN: Secondary analysis of a prospective cohort of 18-40 year old women with 1-2 prior pregnancy losses (n=1193) participating in a multi-center randomized, placebo-controlled trial of low-dose aspirin...
September 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28917266/urinary-biomarkers-in-prostate-cancer-detection-and-monitoring-progression
#10
REVIEW
Duojia Wu, Jie Ni, Julia Beretov, Paul Cozzi, Mark Willcox, Valerie Wasinger, Bradley Walsh, Peter Graham, Yong Li
Prostate cancer (CaP) is the most common cancer in men and the second leading cause of cancer deaths in males in Australia. Although serum prostate-specific antigen (PSA) has been the most widely used biomarker in CaP detection for decades, PSA screening has limitations such as low specificity and potential association with over-diagnosis. Current biomarkers used in the clinic are not useful for the early detection of CaP, or monitoring its progression, and have limited value in predicting response to treatment...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28917223/validity-of-the-malnutrition-universal-screening-tool-must-in-australian-hospitalized-acutely-unwell-elderly-patients
#11
Yogesh Sharma, Campbell Thompson, Billingsley Kaambwa, Rashmi Shahi, Michelle Miller
BACKGROUND AND OBJECTIVES: This study validated the Malnutrition Universal Screening Tool (MUST) for nutritional screening in acutely unwell elderly patients against a reference assessment tool - Patient-Generated Subjective Global Assessment (PG-SGA). METHODS AND STUDY DESIGN: One hundred and thirty two acutely admitted general medical patients contributed data for this study. In addition to performance of MUST and PG-SGA the following nutritional parameters were measured: weight loss >5% in previous 3-6 months, handgrip strength, triceps skinfold thickness, Mid-arm circumference, Mid-arm muscle circumference (MAMC)...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917084/evaluation-of-neurodevelopment-of-children-with-congenital-hypothyroidism-by-the-denver-developmental-screening-test
#12
Ayşe Derya Buluş, Esra Tiftik
BACKGROUND: Thyroid hormones are essential for growth and brain development in childhood. Although congenital hypothyroidism (CH) is the most common reason for mental retardation, normal neurological development can be achieved through early and effective treatment. The aim of the present study was to evaluate the neurological development of CH patients aged 24-56 months. METHODS: The study included a total of 116 healthy control subjects and 112 patients aged 24-56 months who were diagnosed with CH during the neonatal period and were being followed up at the Pediatric Endocrinology Department, Keçiören Training and Research Hospital, between 2012 and 2015...
September 16, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28916564/modulation-of-the-gut-microbiome-a-systematic-review-of-the-effect-of-bariatric-surgery
#13
Yan Guo, Zhi-Ping Huang, Chao-Qian Liu, Lin Qi, Yuan Sheng, Da-Jin Zou
OBJECTIVE: Bariatric surgery is recommended for patients with obesity and type 2 diabetes. Recent evidence suggested a strong connection between gut microbiota and bariatric surgery. DESIGN: Systematic review. METHODS: The PubMed and OVID Embase were used and articles concerning bariatric surgery and gut microbiota were screened. The main outcome measures were alterations of gut microbiota after bariatric surgery and correlations between gut microbiota and host metabolism...
September 15, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28916485/moderate-intravenous-sedation-for-first-trimester-surgical-abortion-a-comparison-of-adverse-outcomes-between-obese-and-normal-weight-women
#14
Gillian Horwitz, Danielle Roncari, Kari Braaten, Rie Maurer, Jennifer Fortin, Alisa B Goldberg
OBJECTIVE: To determine if obese women experience increased rates of adverse outcomes with moderate intravenous sedation during first trimester surgical abortion compared to normal weight women. STUDY DESIGN: We performed a retrospective cohort study of all first trimester surgical abortions with moderate intravenous sedation at an outpatient facility between September 2010 and June 2015. The primary outcome was supplemental oxygen administration. Secondary outcomes included reversal agent administration, anesthesia-related adverse events, and intraoperative lowest level of consciousness (LLOC)...
September 13, 2017: Contraception
https://www.readbyqxmd.com/read/28916025/oral-manifestations-of-nutritional-disorders
#15
Stanislav N Tolkachjov, Alison J Bruce
Nutritional deficiencies occur when body metabolic requirements are not matched by intake and absorption. Reasons for this discrepancy are numerous, but often social, economic, medical, and even psychiatric factors may play a role. Vitamins and minerals are required for appropriate rapid cell turnover of the oral mucosa. The oral cavity is a unique anatomic environment that may manifest early signs of nutritional disorders as well as other indicators of systemic disease. Knowledge of these oral manifestations and associated findings will allow a practitioner to consider a nutritional disorder when evaluating oral changes and, in turn, initiate appropriate therapy...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28915763/extended-screened-exchange-functional-derived-from-transcorrelated-density-functional-theory
#16
Naoto Umezawa
We propose a new formulation of the correlation energy functional derived from the transcorrelated method in use in density functional theory (TC-DFT). An effective Hamiltonian, HTC, is introduced by a similarity transformation of a many-body Hamiltonian, H, with respect to a complex function F: HTC=1FHF. It is proved that an expectation value of HTC for a normalized single Slater determinant, D(n), corresponds to the total energy: E[n] = ⟨Ψ(n)|H|Ψ(n)⟩/⟨Ψ(n)|Ψ(n)⟩ = ⟨D(n)|HTC|D(n)⟩ under the two assumptions: (1) The electron density nr associated with a trial wave function Ψ(n) = D(n)F is v-representable and (2) Ψ(n) and D(n) give rise to the same electron density nr...
September 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28915268/large-scale-cross-species-chemogenomic-platform-proposes-a-new-drug-discovery-strategy-of-veterinary-drug-from-herbal-medicines
#17
Chao Huang, Yang Yang, Xuetong Chen, Chao Wang, Yan Li, Chunli Zheng, Yonghua Wang
Veterinary Herbal Medicine (VHM) is a comprehensive, current, and informative discipline on the utilization of herbs in veterinary practice. Driven by chemistry but progressively directed by pharmacology and the clinical sciences, drug research has contributed more to address the needs for innovative veterinary medicine for curing animal diseases. However, research into veterinary medicine of vegetal origin in the pharmaceutical industry has reduced, owing to questions such as the short of compatibility of traditional natural-product extract libraries with high-throughput screening...
2017: PloS One
https://www.readbyqxmd.com/read/28915154/risk-factors-for-low-back-pain-in-childhood-and-adolescence-a-systematic-review
#18
Inmaculada Calvo-Muñoz, Francisco M Kovacs, Marta Roqué, Inés Gago Fernández, Jesús Seco Calvo
OBJECTIVES: To identify factors associated with low back pain (LBP) in children and adolescents. METHODS: A systematic review was conducted (Prospero CRD42016038186). Observational studies analyzing LBP risk factors among subjects aged between 9 and 16 were searched for in 13 electronic databases and 8 specialized journals until March 31st, 2016, with no language restrictions. Additionally, references in the identified studies were manually tracked. All identified studies which included ≥50 subjects aged 9 to 16, were reviewed...
September 14, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28914998/clinicopathological-characteristics-of-distant-metastases-of-adenocarcinoma-squamous-cell-carcinoma-and-urothelial-carcinoma-an-autopsy-study-of-older-japanese-patients
#19
Yoko Matsuda, Atsuko Seki, Keisuke Nonaka, Mototsune Kakizaki, Tan Wang, Junko Aida, Naoshi Ishikawa, Yuta Nakano, Daita Kaneda, Tadayuki Takata, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kaiyo Takubo, Toshiyuki Ishiwata, Motoji Sawabe, Tomio Arai
AIM: We aimed to clarify the characteristics of malignancies in older adults focusing on distant metastasis in the whole body. METHODS: We retrospectively evaluated 7710 cases of autopsies (4011 men, 3699 women, median age of 80 years), and analyzed the characteristics of metastasis of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma in each organ. RESULTS: The total number of cases with adenocarcinoma, squamous cell carcinoma or urothelial carcinoma was 2856, and most of them were adenocarcinomas...
September 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28914732/predictors-of-weight-related-quality-of-life-in-adolescents-who-are-overweight-or-obese
#20
Carolyn E Ievers-Landis, Oluwatomisin Olayinka, Christopher Burant, Shirley Moore
OBJECTIVE: Weight-related quality of life (WRQOL) is a type of health-related QOL that may serve as a patient-reported outcome of the potential burden of overweight. The present study uses structural equation modeling path analysis methods to examine body mass index (BMI) and other potential predictors of WRQOL components among adolescents who were overweight/obese from predominantly low-income, urban households. METHODS: Baseline data were obtained from 360 participants (10-13 year olds; 57...
September 13, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
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