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https://www.readbyqxmd.com/read/29786877/morphomic-malnutrition-score-a-standardized-screening-tool-for-severe-malnutrition-in-adults
#1
Christopher Lee, Erica Raymond, Brian A Derstine, Joshua M Glazer, Rebecca Goulson, Avinash Rajasekaran, Jill Cherry-Bukowiec, Grace L Su, Stewart C Wang
BACKGROUND: Granular diagnostic criteria for adult malnutrition are lacking. OBJECTIVE: This study uses analytic morphomics to define the Morphomic Malnutrition Score (MMS), a robust screening tool for severe malnutrition. METHODS: The study population (n = 643) consisted of 2 cohorts: 1) 124 emergency department patients diagnosed with severe malnutrition by a registered dietitian (RD) and an available computed tomography (CT) scan within 2 days of RD evaluation, and 2) 519 adult kidney donor candidates to represent a healthy cohort...
May 22, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29785839/optimization-of-a-secondary-voi-protocol-for-lung-imaging-in-a-clinical-ct-scanner
#2
Thomas C Larsen, Vissagan Gopalakrishnan, Jianhua Yao, Catherine P Nguyen, Marcus Y Chen, Joel Moss, Han Wen
We present a solution to meet an unmet clinical need of an in-situ "close look" at a pulmonary nodule or at the margins of a pulmonary cyst revealed by a primary (screening) chest CT while the patient is still in the scanner. We first evaluated options available on current whole-body CT scanners for high resolution screening scans, including ROI reconstruction of the primary scan data and HRCT, but found them to have insufficient SNR in lung tissue or discontinuous slice coverage. Within the capabilities of current clinical CT systems, we opted for the solution of a secondary, volume-of-interest (VOI) protocol where the radiation dose is focused into a short-beam axial scan at the z position of interest, combined with a small-FOV reconstruction at the xy position of interest...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29784890/assessment-of-the-efficacy-of-physical-activity-level-and-lifestyle-behavior-interventions-applying-social-cognitive-theory-for-overweight-and-obese-girl-adolescents
#3
Mohammad Bagherniya, Firoozeh Mostafavi Darani, Manoj Sharma, Mohammad Reza Maracy, Ramesh Allipour Birgani, Golnaz Ranjbar, Ali Taghipour, Mohammad Safraian, Seyed Ali Keshavarz
BACKGROUND: Childhood obesity has become a global epidemic and physical inactivity and considered as one of the most important contributing factors. We aimed to evaluate a school-based physical activity intervention using social cognitive theory (SCT) to increase physical activity behavior in order to prevent obesity among overweight and obese adolescent girls. STUDY DESIGN: Randomized controlled trial study. METHODS: A seven-month randomized controlled trial based on SCT was implemented with 172 overweight and obese girl students (87 in intervention and 85 in control group), with the presence of their parents and teachers...
April 7, 2018: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29781867/accelerated-onset-of-retinal-toxicity-from-hydroxychloroquine-use-with-concomitant-breast-cancer-therapy
#4
Aman Sharma, Alejandra M Maiz, William R Tucker, Catherine Cukras
PURPOSE: To report a case of accelerated retinal toxicity due to hydroxychloroquine (HCQ) use for treatment of Sjögren syndrome in a patient treated with concomitant chemotherapy for breast cancer. METHODS: Observational case report. RESULTS: A 56-year-old white woman using 400 mg HCQ (7.1 mg/kg real body weight) daily for a total of 2 years and 10 months for treatment of Sjögren syndrome with concomitant use of docetaxel and cyclophosphamide therapy (21-day cycle, 4 cycles) followed by anastrozole for breast cancer, presented with visual complaints and findings of severe HCQ toxicity...
May 16, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29781584/erythema-ab-igne
#5
Isabelle Marie
A 41 year-old woman was diagnosed as having limited cutaneous systemic sclerosis (SSc) in March 2012. The cutaneous impairment of SSc was characterized by sclerodactyly associated with pitting scars; systemic manifestations of SSc included esophageal involvement, with both absence of peristalsis in the lower two-thirds of the oesophageal body and low pressure in the lower oesophageal sphincter. In 2017, the patient presented with livedo reticularis lesions of her abdomen (Panel A) evolving for one month. The patient denied pruritus, pain, or exposure of abdomen to irritants prior to lesion onset...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#6
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29779870/central-adiposity-markers-plasma-lipid-profile-and-cardiometabolic-risk-prediction-in-overweight-obese-individuals
#7
Rocco Barazzoni, Gianluca Gortan Cappellari, Annamaria Semolic, Mario Ius, Michela Zanetti, Antonio Gabrielli, Pierandrea Vinci, Gianfranco Guarnieri, Giorgio Simon
BACKGROUND: Waist circumference (WC) is the currently recommended marker of central fat for cardiometabolic risk screening. Alternative surrogate markers have been recently proposed to better reflect the metabolic impact of central fat accumulation per se, based on WC normalization by height (Weight-to-Height Ratio - WtoH; Body Roundness Index - BRI) or body mass index (BMI) without (A Body Shape Index - ABSI) or with inclusion of plasma triglyceride and HDL-cholesterol concentrations (Visceral Adiposity Index - VAI)...
May 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29779697/usefulness-of-controlled-attenuation-parameter-for-detecting-increased-arterial-stiffness-in-general-population
#8
Hyo Eun Park, Heesun Lee, Su-Yeon Choi, Min-Sun Kwak, Jong In Yang, Jeong Yoon Yim, Goh Eun Chung
BACKGROUND: Liver fibroscan has recently been suggested as an alternative method to measure liver steatosis noninvasively. In this study, we evaluated usefulness of controlled attenuation parameter (CAP) for detecting increased arterial stiffness in general population. METHODS: A total of 515 asymptomatic patients without potential cause of liver disease who had liver fibroscan and cardio-ankle vascular index (CAVI) during their health check-up exams were included...
May 4, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29779466/a-systematic-review-of-shock-attenuating-componentry-for-lower-limb-amputees
#9
Mitchell Farrar, Emma Thomas
BACKGROUND: Shock-attenuating pylons are commonly fitted to prostheses in order to compensate for the anatomical and biomechanical shock-absorbing features of the lower limb removed upon amputation. However, studies concerning their shock-attenuating capacity are highly variable and, to date, have not yet been reviewed, making them difficult to interpret and apply in clinical practice. OBJECTIVES: To synthesise and appraise the available literature examining the effectiveness of shock-attenuating pylons in attenuating shock upon limb loading compared to rigid pylons among lower limb amputees...
May 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29778786/body-weight-and-breast-cancer-nested-case-control-study-in-southern-brazil
#10
Natália Luiza Kops, Marina Bessel, Maira Caleffi, Rodrigo Antonini Ribeiro, Eliana Marcia Wendland
BACKGROUND: Current studies have shown that fast weight gain may be more important than body mass index on the incidence of breast cancer. The aim of this study was to evaluate the association between body weight and breast cancer. PATIENTS AND METHODS: This was a case-control study nested in a cohort of a breast cancer mammography screening program in Southern Brazil. A trained investigator administered a standardized interview to collect sociodemographic and clinical data, and body weight history (weight at menarche, at marriage, at first and last pregnancy, and at menopause)...
April 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29777949/evaluation-of-skin-or-sweat-characteristic-mrnas-for-inferring-the-human-origin-of-touched-contact-traces
#11
Tomoko Akutsu, Ken Watanabe, Ayari Takamura, Koichi Sakurada
The source of small amounts of touch DNA, which is transferred from the skin to an object when it is handled or touched, could be an issue in the forensic analysis of criminal cases. Here, we performed an extended evaluation of skin- or sweat-characteristic mRNAs to investigate their usability to infer whether an object has been handled or touched by someone. First, we compared the expression levels of candidate genes between skin swabs and other body fluids by quantitative RT-PCR analysis. Among the analyzed genes, corneodesmosin (CDSN), late cornified envelope 1C (LCE1C), filaggrin (FLG), desmocollin 1, and dermcidin were selected for further analysis on the basis of their specificities and sensitivities...
May 14, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29777900/material-basis-research-for-huangqi-jianzhong-tang-against-chronic-atrophic-gastritis-rats-through-integration-of-urinary-metabonomics-and-systemsdock
#12
Yuetao Liu, Wenqian Xu, GuoHong Wang, Xuemei Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Huangqi Jianzhong Tang (HQJZ), a celebrated traditional Chinese medicine (TCM), is commonly used for treatment of chronic atrophic gastritis (CAG) in China. AIM OF THE STUDY: We aimed to screen out the material basis of HQJZ against CAG. MATERIALS AND METHODS: CAG rat model was constructed by alternant administrations of ammonia solution and sodium deoxycholate, and the hunger disorder method. Body weight, biochemical indexes and histopathological exam were used to evaluate the efficacy of HQJZ...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777851/point-of-care-ultrasound-performed-by-a-medical-student-compared-to-physical-examination-by-vascular-surgeons-in-the-detection-of-abdominal-aortic-aneurysms
#13
Trinh Mai, Michael Y Woo, Kim Boles, Prasad Jetty
OBJECTIVE: To determine the test characteristics of point-of-care ultrasonography performed by a medical student versus physical examination by vascular surgeons compared to a gold standard reference scan for the detection of abdominal aortic aneurysms. METHODS: We conducted a prospective, observer-blinded study recruiting patients from an outpatient vascular surgery clinic. Participants were screened for abdominal aortic aneurysms by standardized physical examination by a blinded vascular surgeon, followed by a point-of-care ultrasound examination by a blinded medical student...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29776474/correlates-of-physical-activity-and-sedentary-behaviors-among-overweight-hispanic-school-aged-children
#14
Kimberly R Hartson, Bonnie Gance-Cleveland, Claudia R Amura, Sarah Schmiege
PURPOSE: The purpose of this study was to explore potential correlates of physical activity and sedentary screen time behaviors among overweight Hispanic school-aged children, ages 7 to 14years. DESIGN AND METHODS: We conducted an exploratory correlation analysis using baseline data of 40 child-parent dyads from the "Mind Exercise Nutrition Do It!" program conducted in the Western United States. RESULTS: Child self-esteem and parental vegetable intake were moderately associated with physical activity, while parental vegetable intake and child fruit intake were strongly associated with physical activity among males...
May 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29775238/comparison-of-creatinine-index-and-geriatric-nutritional-risk-index-for-nutritional-evaluation-of-patients-with-hemodialysis
#15
Wonsun Hwang, Mi Sook Cho, Ji Eun Oh, Ji Hyun Lee, Jong Cheol Jeong, Gyu-Tae Shin, Heungsoo Kim, Inwhee Park
INTRODUCTION: Malnutrition is prevalent in hemodialysis (HD) patients, and the risk of mortality is strongly correlated with malnutrition. Current methods of nutritional evaluation are mostly subjective, time-consuming, and cumbersome. Creatinine index (CI) and geriatric nutritional risk index (GNRI) are very simple and objective methods to assess the nutritional status of HD patients. The present study compares the performance of CI and GNRI as nutritional risk assessment tools. METHODS: Eighty-eight patients with end-stage renal disease on HD were recruited from a single tertiary center...
May 18, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29775081/reference-values-of-left-heart-echocardiographic-dimensions-and-mass-in-male-peri-pubertal-athletes
#16
Elena Cavarretta, Francesco Maffessanti, Fabio Sperandii, Emanuele Guerra, Federico Quaranta, Antonia Nigro, Monia Minati, Marco Rebecchi, Chiara Fossati, Leonardo Calò, Fabio Pigozzi
Background Several articles have proposed reference values in healthy paediatric subjects, but none of them has evaluated a large population of healthy trained adolescents. Design The study purpose was to establish normal echocardiographic measurements of left heart (aortic root, left atrium and left ventricular dimensions and mass) in relation to age, weight, height, body mass index, body surface area and training hours in this specific population. Methods We retrospectively evaluated 2151 consecutive, healthy, peri-pubertal athletes (100% male, mean age 12...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29774984/comments-on-recent-reports-on-infrared-spectral-detection-of-disease-markers-in-blood-components
#17
Max Diem
The search for disease markers in whole blood, or easily accessible blood components by spectral methods is a highly important aspect in the field of biophotonic research for disease diagnostics and screening, since it promises a minimally invasive approach to assess an individual's state of health. Fourier transform infrared spectroscopy, in particular, promises to be a fast, inexpensive method to search for markers of disease, since it detects variation in the proteome, lipidome and metabolome of biofluids, or activation of immune cells...
May 18, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29773000/evaluation-of-antiarthritic-activity-of-butanol-fraction-of-punica-granatum-linn-rind-extract-against-freund-s-complete-adjuvant-induced-arthritis-in-rats
#18
Rupesh Kumar Gautam, Sanjay Sharma, Komal Sharma, Gaurav Gupta
Available conventional drugs produce several side effects; thus, a potent herbal drug is urgently required for the management of rheumatoid arthritis. The present investigation was performed to evaluate the antiarthritic activity of butanol fraction of Punica granatum Linn. rind methanolic extract (PGBF) against Freund's complete adjuvant (FCA)-induced arthritis in rats. An acute toxicity study of butanol fraction was conducted, accompanied by a study of its antiarthritic activity. Chromatography (thin layer chromatography and high-performance thin layer chromatography) analyses were also conducted...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29772928/a-clinical-carepath-for-obese-pregnant-women-a-pragmatic-pilot-cluster-randomized-controlled-trial
#19
Sarah D McDonald, Kristen A Viaje, Rebecca A Rooney, Alexander Jarde, Lucia Giglia, Cynthia V Maxwell, David Small, Tracy Pearce Kelly, B H Sc Midwifery, Lisa Sabatino, Lehana Thabane
OBJECTIVES: Obese women are at increased risks for complications during pregnancy, birth and in their infants. Although guidelines have been established for the clinical care of obese pregnant women, management is sometimes suboptimal. Our goal was to determine the feasibility of implementing and testing a clinical carepath for obese pregnant women compared to standard care, in a pilot cluster randomized controlled trial (RCT). METHODS: A pragmatic pilot cluster RCT was conducted, randomly allocating eight clinics to the carepath or standard care for obese pregnant women...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29772819/do-young-people-ever-sit-still-variations-in-accelerometer-counts-muscle-activity-and-heart-rate-across-various-sedentary-activities-in-youth
#20
Evi van Ekris, Mai J M Chinapaw, Joost Rotteveel, Teatske M Altenburg
Evidence of adverse health effects of TV viewing is stronger than for overall sedentary behaviour in youth. One explanation may be that TV viewing involves less body movement than other sedentary activities. Variations in body movement across sedentary activities are currently unknown, as are age differences in such variations. This study examined body movement differences across various sedentary activities in children and adolescents, assessed by hip-, thigh- and wrist-worn accelerometers, muscle activity and heart rate...
May 17, 2018: International Journal of Environmental Research and Public Health
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