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Nataniel H Lester-Coll, Charles E Rutter, Suzanne B Evans
BACKGROUND AND PURPOSE: Breast radiotherapy (RT) for elderly women with estrogen receptor positive early stage breast cancer (ER+ESBC) improves local recurrence (LR) rates without benefitting overall survival. Breast boost is a common practice, although the absolute benefit decreases with age. Consequently, an analysis of its cost-effectiveness in the elderly ESBC populations is warranted. MATERIAL AND METHODS: A Markov model was used to compare cost-effectiveness of RT with or without a boost in elderly ER+ESBC patients...
April 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Tingting Du, Gang Yuan, Xinrong Zhou, Xingxing Sun
OBJECTIVE: Sex differences in the association of HbA1c and cardiovascular disease (CVD) risk remain controversial. We examined CVD risk profile in both HbA1c-defined diabetic and nondiabetic men and women. METHODS: We conducted a cross-sectional analysis of 7139 Chinese adults using data from the China Health and Nutrition Survey 2009. RESULTS: HbA1c-defined nondiabetic men have a more favorable CVD risk profile than female counterparts. However, HbA1c-defined diabetic men have higher levels of triglyceride, low-density lipoprotein (LDL)-cholesterol, and triglyceride/high-density lipoprotein (HDL)-cholesterol and lower levels of HDL-cholesterol, be more visceral obese as indicated by visceral adiposity index (VAI) and lipid accumulation product (LAP), and more insulin resistant as assessed by the triglycerides and glucose index (TyG) than HbA1c-defined diabetic women...
2016: Annals of Medicine
Marianne O Hesselager, Marius C Codrea, Zhi Sun, Eric W Deutsch, Tue B Bennike, Allan Stensballe, Louise Bundgaard, Robert L Moritz, Emøke Bendixen
Biological research of Sus scrofa, the domestic pig, is of immediate relevance for food production sciences, and for developing pig as a model organism for human biomedical research. Publicly available data repositories play a fundamental role for all biological sciences, and protein data repositories are in particular essential for the successful development of new proteomic methods. Cumulative proteome data repositories, including the PeptideAtlas, provide the means for targeted proteomics, system-wide observations, and cross-species observational studies, but pigs have so far been underrepresented in existing repositories...
February 2016: Proteomics
Mukesh C Sharma
In the present investigation, quantitative structure-activity relationship (QSAR) analysis was performed on a data set consisting of structurally diverse compounds in order to investigate the role of their structural features on their photosynthetic electron transport Inhibitors. The best 2D-QSAR model was selected, having correlation coefficient r (2) = 0.8544 and cross-validated squared correlation coefficient q (2) = 0.7139 with external predictive ability of pred_r (2) = 0.7753. The results obtained in this study indicate that the presence of hydroxy and nitro groups, expressed by the SsOHcount and SddsN (nitro) count, is the most relevant molecular property determining efficiency of photosynthetic inhibitory...
June 2016: Interdisciplinary Sciences, Computational Life Sciences
Sydney A Jones, Latetia V Moore, Kari Moore, Melissa Zagorski, Shannon J Brines, Ana V Diez Roux, Kelly R Evenson
OBJECTIVE: We conducted an ecological study to determine physical activity resource availability overall and by sociodemographic groups in parts of six states (CA, IL, MD, MN, NC, NY). METHODS: Data on parks and recreational facilities were collected from 3 sources in 2009-2012. Three measures characterized park and recreational facility availability at the census tract level: presence of ≥1 resource, number of resources, and resource kernel density. Associations between resource availability and census tract characteristics (predominant racial/ethnic group, median income, and proportion of children and older adults) were estimated using linear, binomial, and zero-inflated negative binomial regression in 2014...
September 2015: Preventive Medicine
Li Gao, Xue Ye, Rui-Qiong Ma, Hong-Yan Cheng, Hong-Jing Han, Heng Cui, Li-Hui Wei, Xiao-Hong Chang
BACKGROUND: Ovarian cancer is a leading gynecological malignancy. We investigated the prognostic value of programmed cell death 5 (PDCD5) in patients with ovarian cancer. METHODS: Expression levels of PDCD5 mRNA and protein were examined in six ovarian cancer cell lines (SKOV3, CAOV3, ES2, OV1, 3AO, and HOC1A) and one normal ovarian epithelial cell line (T29) using reverse transcription polymerase chain reaction, Western blotting, and flow cytometry. After inducing PDCD5 induction in SKOV3 cells or treating this cell line with taxol or doxorubicin (either alone or combined), apoptosis was measured by Annexin V-FITC/propidium iodide staining...
April 20, 2015: Chinese Medical Journal
Kailin Xu, Shoujun Zheng, Yuanming Zhai, Liuqi Guo, Peixiao Tang, Jin Yan, Di Wu, Hui Li
Two phase-pure solid forms of tauroursodeoxycholic acid (TUDCA) were prepared and characterized by thermal analysis, vibrational spectroscopy, X-ray diffraction, solid-state nuclear magnetic resonance, and morphological analysis. All solid forms can be produced from solvents and also can be obtained by mechanically and non-mechanically activated polymorph conversion. Near-infrared (NIR) spectroscopy, in combination with chemometrical techniques, was used for the quantitative monitoring of the polymorph conversion of TUDCA in milling process and at different storage temperatures...
2015: International Journal of Pharmaceutics
Xuejiao Guan, Chongxi Liu, Junwei Zhao, Baozhu Fang, Yuejing Zhang, Lianjie Li, Pinjiao Jin, Xiangjing Wang, Wensheng Xiang
A novel actinomycete, designated strain NEAU-Spg16(T), was isolated from a soil sample from a pine forest in Songpinggou, Maoxian, southwest China. A polyphasic taxonomic study was carried out to establish the status of strain NEAU-Spg16(T). The cell wall peptidoglycan was found to contain LL-diaminopimelic acid and glycine. The major menaquinones were identified as MK-9(H8), MK-9(H4) and MK-9(H6). The phospholipid profile was found to contain diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol and an unidentified phospholipid...
May 2015: Antonie Van Leeuwenhoek
Mukesh C Sharma
In the present investigation, QSAR analysis was performed on a data set consist of structurally diverse compounds in order to investigate the role of its structural features on their Photosynthetic Electron Transport Inhibitors. The herbicidal activity co-related with certain topological and hydrophobicity based descriptors, 3D descriptors dependent steric, electrostatic and hydrophobic. The best 2D QSAR model was selected, having correlation coefficient r(2) = 0.8544 and cross validated squared correlation coefficient q(2) = 0...
September 2, 2014: Interdisciplinary Sciences, Computational Life Sciences
Jasvinder A Singh, David G Lewallen
OBJECTIVE: To study patient-level improvements in pain and limitations of key activities of daily living (ADLs) after primary or revision total knee arthroplasty (TKA). METHODS: We analysed prospectively collected data from the Mayo Clinic Total Joint Registry for improvements in index knee pain severity and limitations in three key ADLs (walking, climbing stairs and rising from a chair) from pre-operative to 2 and 5 years post-TKA. RESULTS: The primary TKA cohort consisted of 7229 responders pre-operatively, 7139 at 2 years and 4234 at 5 years post-operatively...
February 2014: Rheumatology
Nichollas E Scott, Nathan J Hare, Melanie Y White, Jim Manos, Stuart J Cordwell
Pseudomonas aeruginosa is the predominant cause of mortality in patients with cystic fibrosis (CF). We examined the secretome of an acute, transmissible CF P. aeruginosa (Australian epidemic strain 1-R; AES-1R) compared with laboratory-adapted PAO1. Culture supernatant proteins from rich (LB) and minimal (M9) media were compared using 2-DE and 2DLC-MS/MS, which revealed elevated abundance of PasP protease and absence of AprA protease in AES-1R. CF lung-like artificial sputum medium (ASMDM) contains serum and mucin that generally preclude proteomics of secreted proteins...
December 6, 2013: Journal of Proteome Research
Jasvinder A Singh, David G Lewallen
We assessed the association of cerebrovascular disease preoperatively with patient-reported outcomes (PROs) of moderate-severe activity limitation and moderate-severe pain at 2- and 5-years after primary total knee arthroplasty (TKA) using multivariable-adjusted logistic regression; 7139 primary and 4234 revision TKAs were included. Compared to the patients without cerebrovascular disease, those with cerebrovascular disease had a higher odds ratio (OR) of moderate-severe limitation at 2 years and 5 years, 1...
January 2014: Journal of Arthroplasty
C Handa, S Goomer, A Siddhu
Short dough cookies were enriched with fructoligosaccharide (FOS), a prebiotic soluble fiber and a low calorie sweetener, at levels of 40%, 60%, and 80% sugar replacement basis. Cookies were analyzed for diameter, height, spread ratio, hardness, moisture and acidity of the extracted fat. The mean peak force at 0 month was determined to be 7139 ± 166 g, 7109 ± 75 g, 6970 ± 24 g and 6538 ± 128 g for control (100% sucrose), 40%, 60% and 80% sugar replacement levels cookies respectively...
April 2012: Journal of Food Science and Technology
D de Ridder, T Roumeguère, L Kaufman
AIM:  This Belgian epidemiological study aimed to assess the prevalence of overactive bladder (OAB) and stress urinary incontinence (SUI) and associated bother in a female primary care population. METHODS: Data on OAB and SUI were prospectively collected among women ≥ 40 years by general practitioners (GP) during a regular visit for any reason. The validated Bladder Control Self-Assessment Questionnaire (B-SAQ) was used and complemented with a question on SUI and bladder bother...
March 2013: International Journal of Clinical Practice
Jasvinder A Singh, David G Lewallen
OBJECTIVE: To study comorbidity correlates of moderate to severe pain after total knee arthroplasty (TKA). METHODS: We analysed prospectively collected Total Joint Registry data to examine whether medical (heart disease, peripheral vascular disease, renal disease, chronic obstructive pulmonary disease, diabetes and CTD) and psychological (anxiety and depression) comorbidity is associated with moderate to severe pain after primary or revision TKA. Multivariable-adjusted logistic regression simultaneously adjusted for all comorbidities, age, sex, BMI, underlying diagnosis, American Society of Anesthesiologist (ASA) class, distance from medical centre and implant fixation (only for primary TKA) was used to analyse primary and revision TKA separately...
May 2013: Rheumatology
Ariel Berger, John Edelsberg, Simon Teal, Marko A Mychaskiw, Gerry Oster
BACKGROUND: Little is known concerning the degree to which initiation of sildenafil for pulmonary arterial hypertension (PAH) impacts patterns of healthcare utilization and costs. METHODS: Using a large US health insurance claims database, we identified all patients with evidence of PAH (ICD-9-CM diagnosis codes 416.0, 416.8) who received sildenafil between 1/1/2005 and 9/30/2008. Date of the first-noted prescription for sildenafil was designated the "index date," and claims data were compiled for all study subjects for 6 months prior to their index date ("pretreatment") and 6 months thereafter ("follow-up"); patients with incomplete data during either of these periods were excluded...
2012: BMC Pulmonary Medicine
L Feng, J Li, T-P Ng, T-S Lee, E-H Kua, Y Zeng
OBJECTIVE: We examined the longitudinal association between tea drinking frequency and cognitive function in a large sample of oldest-old Chinese. DESIGN: population-based longitudinal cohort study. SETTING: The Chinese Longitudinal Healthy Longevity Survey (CLHLS). PARTICIPANTS: 7139 participants aged 80 to 115 (mean age 91.4 years) who provided complete data at baseline (year 1998). MEASUREMENTS: Current frequency of tea drinking and past frequency at age 60 were ascertained at baseline, and baseline and follow-up cognitive assessments were performed in the years 1998 (n=7139), 2000 (n=4081), 2002 (n=2288) and 2005 (n=913) respectively...
2012: Journal of Nutrition, Health & Aging
Abdulkadir Gunduz, Asim Kalkan, Suleyman Turedi, Ismet Durmus, Suha Turkmen, Faik Ahmet Ayaz, Ahmet Ayar
BACKGROUND: The symptoms of mad honey poisoning resemble those of cholinergic toxidromes; however, it is not clear whether they share a common biochemical basis. OBJECTIVES: The aim of this study was to investigate a possible resemblance between mad honey poisoning and cholinergic toxidromes. METHODS: This is a descriptive study performed prospectively in patients presenting to a University Medical Faculty Emergency Medicine Department emergency service with mad honey poisoning over 1 year, from September 2008 to September 2009...
December 2012: Journal of Emergency Medicine
Ayako Kataoka, Yui Koga, Ayumi Uesugi, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue
Microglia are major immunocompetent cells in the central nervous system and retain highly dynamic motility. The processes which allow these cells to move, such as chemotaxis and phagocytosis, are considered part of their functions and are closely related to purinergic signaling. Previously, we reported that the activation of the P2Y(6) receptor by UDP stimulation in microglia evoked dynamic cell motility which enhanced their phagocytic capacity, as reported by Koizumi et al. (Nature 446(7139):1091-1095, 2007)...
December 2011: Purinergic Signalling
Rod L Balhorn, Katherine A Skorupski, Saphon Hok, Monique Cosman Balhorn, Teri Guerrero, Robert B Rebhun
Therapies using antibodies directed against cell surface proteins have improved survival for human patients with non-Hodgkin's lymphoma (NHL). It is possible that similar immuno-therapeutic approaches may also benefit canine NHL patients. Unfortunately, variability between human and canine epitopes often limits the usefulness of such therapies in pet dogs. The Lym-1 antibody recognizes a unique epitope on HLA-DR10 that is expressed on the majority of human B-cell malignancies. The Lym-1 antibody has now been observed to bind to dog lymphocytes and B-cell NHL...
October 15, 2010: Veterinary Immunology and Immunopathology
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