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https://www.readbyqxmd.com/read/29932111/protective-effect-of-octylmethoxycinnamate-against-uv-induced-photoaging-in-hairless-mouse-via-the-regulation-of-matrix-metalloproteinases
#1
So Young Kim, Santosh Lamichhane, Jung-Hun Ju, Jaesuk Yun
Ultraviolet (UV) irradiation damages skin and produces symptoms of photoaging, such as thickening, rough texture, wrinkles, and pigmentation. However, the cellular and molecular mechanisms underlying photoaging induced by chronic UV irradiation are not yet fully understood. Matrix metalloproteinases (MMPs) have been reported to be involved in the response to UV irradiation. In this study, we examined the effects of the sunscreen agent Octylmethoxycinnamate (OMC) on photoaging of the skin induced by chronic UV exposure in hairless albino Crl:SKH1- Hrhr (SKH-1) mice...
June 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29926349/production-of-functional-human-cuzn-sod-and-ec-sod-in-bitransgenic-cloned-goat-milk
#2
Rui Lu, Ting Zhang, Daijin Wu, Zhengyi He, Lei Jiang, Minya Zhou, Yong Cheng
Human copper/zinc superoxide dismutase (CuZn-SOD) and extracellular superoxide dismutase (EC-SOD) are two superoxide dismutases that scavenge reactive oxygen species (ROS). Their biological role of eliminating oxidative stress caused by excessive ROS levels in living organisms has been utilized in medical treatment, preventing skin photoaging and food preservation. In this study, we employed two sequences that encode human CuZn-SOD and EC-SOD, along with goat beta-casein 5' and 3' regulatory elements, to construct mammary gland-specific expression vectors...
June 20, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29908579/herbal-sun-protection-agents-human-studies
#3
Lana Rabinovich, Viktoryia Kazlouskaya
Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Herbal substances may work as adsorbents of the UV rays and antioxidants and potentially have few side effects...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29901204/protective-effect-of-crocin-on-ultraviolet-b%C3%A2-induced-dermal-fibroblast-photoaging
#4
Mingwu Deng, Dong Li, Yichen Zhang, Guangdong Zhou, Wei Liu, Yilin Cao, Wenjie Zhang
Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS), resulting in the aging of dermal fibroblasts. Crocin, a bioactive constituent of Crocus sativus, possesses anti‑oxidation effects. The purpose of the present study was to evaluate the protective effect of crocin on UVB‑induced dermal fibroblast photoaging. Human dermal fibroblasts were isolated and cultured with different concentrations of crocin prior to and following exposure to UVB irradiation. The senescent phenotypes of cells were evaluated, including cell proliferation, cell cycle, senescence‑associated β‑galactosidase (SA‑β‑gal) expression, intracellular ROS, expression of antioxidant protein glutathione peroxidase 1 (GPX‑1) and extracellular matrix protein collagen type 1 (Col‑1)...
June 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29898032/long-non-coding-rna-hotair-promotes-uvb-induced-apoptosis-and-inflammatory-injury-by-up-regulation-of-pkr-in-keratinocytes
#5
Guo Liu, Wenhao Zhang
Excessive exposure to ultraviolet (UV) rays can cause damage of the skin and may induce cancer, immunosuppression, photoaging, and inflammation. The long non-coding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) is involved in multiple human biological processes. However, its role in UVB-induced keratinocyte injury is unclear. This study was performed to investigate the effects of HOTAIR in UVB-induced apoptosis and inflammatory injury in human keratinocytes (HaCaT cells). Quantitative real-time polymerase chain reaction was performed to analyze the expression levels of HOTAIR, PKR, TNF-α, and IL-6...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29890746/exosomes-derived-from-human-induced-pluripotent-stem-cells-ameliorate-the-aging-of-skin-fibroblasts
#6
Myeongsik Oh, Jinhee Lee, Yu Jin Kim, Won Jong Rhee, Ju Hyun Park
Stem cells and their paracrine factors have emerged as a resource for regenerative medicine. Many studies have shown the beneficial effects of paracrine factors secreted from adult stem cells, such as exosomes, on skin aging. However, to date, few reports have demonstrated the use of exosomes derived from human pluripotent stem cells for the treatment of skin aging. In this study, we collected exosomes from the conditioned medium of human induced pluripotent stem cells (iPSCs) and investigated the effect on aged human dermal fibroblasts (HDFs)...
June 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29883215/dual-wavelength-treatment-protocol-with-a-picosecond-laser-for-the-reduction-of-facial-wrinkles
#7
Michael H Gold
INTRODUCTION: The potential of a dual wavelength picosecond laser, as a new modality for treating photoaged skin, was investigated in this clinical study. MATERIAL AND METHODS: Subjects with bilateral mild-to-moderate facial wrinkling received four picosecond laser treatments, at 3-8 weeks apart, with a double-pass of both 532-nm and 1064-nm split-beam handpieces. Blinded evaluation of clinical photography, by two independent physicians, using the Fitzpatrick Elastosis Scale, was performed at 12 weeks after the fourth treatment...
June 8, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29881301/antiaging-effects-of-a-novel-facial-serum-containing-l-ascorbic-acid-proteoglycans-and-proteoglycan-stimulating-tripeptide-ex-vivo-skin-explant-studies-and-in-vivo-clinical-studies-in-women
#8
Aurora Garre, Mridvika Narda, Palmira Valderas-Martinez, Jaime Piquero, Corinne Granger
Background: With age, decreasing dermal levels of proteoglycans, collagen, and elastin lead to the appearance of aged skin. Oxidation, largely driven by environmental factors, plays a central role. Aim: The aim of this study was to assess the antiaging efficacy of a topical serum containing L-Ascorbic acid, soluble proteoglycans, low molecular weight hyaluronic acid, and a tripeptide in ex vivo and in vivo clinical studies. Methods: Photoaging and photo-oxidative damage were induced in human skin explants by artificial solar radiation...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29867483/photoprotective-properties-of-isothiocyanate-and-nitrile-glucosinolate-derivatives-from-meadowfoam-limnanthes-alba-against-uvb-irradiation-in-human-skin-equivalent
#9
Evan L Carpenter, Mai N Le, Cristobal L Miranda, Ralph L Reed, Jan F Stevens, Arup K Indra, Gitali Ganguli-Indra
Exposure to ultraviolet B (UVB) irradiation of the skin leads to numerous dermatological concerns including skin cancer and accelerated aging. Natural product glucosinolate derivatives, like sulforaphane, have been shown to exhibit chemopreventive and photoprotective properties. In this study, we examined meadowfoam ( Limnanthes alba ) glucosinolate derivatives, 3-methoxybenzyl isothiocyanate (MBITC) and 3-methoxyphenyl acetonitrile (MPACN), for their activity in protecting against the consequences of UV exposure...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29862491/effectiveness-and-safety-of-0-5-colchicine-cream-versus-photodynamic-therapy-with-methyl-aminolevulinate-in-the-treatment-of-actinic-keratosis-and-skin-field-cancerisation-of-the-forearms-a-randomized-controlled-trial
#10
A C Miola, E F Roio, T R R Lima, J V Schmitt, L P F Abbade, H A Miot
BACKGROUND: Skin field cancerisation (SFC) is an area with UVR induced genomic alterations. Actinic keratosis (AK) is a sign of its activity. OBJECTIVE: Evaluate effectiveness and safety of 0.5% colchicine cream versus MAL-PDT in treating AK and SFC. PATIENTS AND METHODS: Randomised, open, intrasubject controlled trial: 36 participants, with 3-10 AK in each forearm, treated with colchicine (COL) cream (twice daily for 10 days) or a single session of MAL-PDT, reassessed after 60 days...
June 3, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29858421/efficacy-of-phototherapy-to-treat-facial-ageing-when-using-a-red-versus-an-amber-led-a-protocol-for-a-randomised-controlled-trial
#11
Lidiane Rocha Mota, Lara Jansiski Motta, Ivone da Silva Duarte, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani
INTRODUCTION: The skin undergoes morphological and physiological changes with the advancing age of an individual. These changes may be caused by intrinsic and extrinsic factors that contribute to cellular ageing and consequent skin ageing. The term photoageing is used to characterise the ageing of the skin caused by solar radiation. Clinically, the skin becomes more flaccid, thicker and hyperpigmented, while there is an early appearance of wrinkles and other skin changes, such as skin cancer...
May 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29785318/role-of-nanotechnology-in-cosmeceuticals-a-review-of-recent-advances
#12
REVIEW
Shreya Kaul, Neha Gulati, Deepali Verma, Siddhartha Mukherjee, Upendra Nagaich
Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use...
2018: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29779217/ginsenoside-c-mx-isolated-from-notoginseng-stem-leaf-ginsenosides-attenuates-ultraviolet-b-mediated-photoaging-in-human-dermal-fibroblasts
#13
Xiao-Yi Liu, Eunson Hwang, Bom Park, Hien T T Ngo, Yong-Kun Xiao, Tae-Hoo Yi
Notoginseng is a traditional herbal medicine widely used for medicinal therapy in Asia, as it contains numerous ginsenosides with pharmacological effects. In this study, we submitted Notoginseng stem-leaf (NGL) ginsenosides to an enzyme to create reaction the monomer products of ginsenoside C-Mx and then investigated the ability of ginsenoside C-Mx to protect the skin against ultraviolet B-induced injury in normal human dermal fibroblasts (NHDFs). Ginsenoside C-Mx alleviated UVB-induced intracellular reactive oxygen species (ROS), MMP-1, and IL-6 expression while accelerating TGF-β and procollagen type I secretion...
May 20, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29768726/ribes-nigrum-l-prevents-uvb-mediated-photoaging-in-human-dermal-fibroblasts-potential-antioxidant-and-anti-inflammatory-activity
#14
Lu Li, Eunson Hwang, Hien T T Ngo, Seul A Seo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi
Black currants (Ribes nigrum L, RN) are known as a "super fruit" to possess for their many potential health benefits such as the alleviation of oxidative stress-related disorders. However, little skin photoaging-related research has been done on the use of this agent. In the present study, we investigated the protective effects of RN in UVB-irradiated human dermal fibroblasts (NHDFs). RN treatment in UVB-irradiated skin models alleviated UVB-mediated photoaging through several mechanisms: Treatment with RN downregulated MAPK-related signaling models, such as those of activation protein 1 (AP-1) and nuclear factor kappa B (NF-κB)...
May 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29755556/defensive-properties-of-ginsenoside-re-against-uv-b-induced-oxidative-stress-through-up-regulating-glutathione-and-superoxide-dismutase-in-hacat-keratinocytes
#15
Daehyun Shin, Hee Won Moon, Yuri Oh, Kyunghoon Kim, Dae-Duk Kim, Chang-Jin Lim
Ginseng is now used worldwide as a traditional Oriental medicine. Ginsenosides, also known as ginseng saponins, are responsible for most pharmacological efficacies of ginseng. This work aimed to assess the novel skin anti-photoaging potential of ginsenoside Re (Re), a protopanaxatriol-type ginsenoside, by analyzing reactive oxygen species (ROS), pro-matrix metalloproteinase-2 (proMMP-2) and -9 (proMMP-9), total glutathione (GSH), superoxide dismutase (SOD), and cellular viability in UV-B-irradiated HaCaT keratinocytes...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29748977/paeonol-extracted-from-paeonia-suffruticosa-andr-ameliorated-uvb-induced-skin-photoaging-via-dld-nrf2-are-and-mapk-ap-1-pathway
#16
ZhengWang Sun, Juan Du, Eunson Hwang, Tae-Hoo Yi
Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)-induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB-induced phosphorylation of mitogen-activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 expression, confirmed by greater nuclear accumulation of nuclear factor E2-releated factor 2 (Nrf2)...
May 10, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29737899/resveratrol-as-an-active-ingredient-for-cosmetic-and-dermatological-applications-a-review
#17
Anna Ratz-Łyko, Jacek Arct
Resveratrol is now being increasingly used in cosmetology and dermatology. This polyphenolic phytoalexin present in large amounts in red grapes and berries has a number of scientifically proven health-promoting properties associated with a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein, and the ability to inhibit the cyclooxygenases activity. Additionally, it has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties...
May 8, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29710031/enzyme-treated-asparagus-extract-etas-facilitates-the-turnover-of-uv-b-irradiated-keratinocytes
#18
Tomoko Koda, Ken Shirato, Jun Takanari, Hideki Imai
Enzyme-treated asparagus extract (ETAS) is prepared from the lower, residual parts of asparagus, and some functionalities, such as anti-oxidative and neuroprotective activities, have been suggested. The purpose of the present study was to investigate the effects of ETAS on photoaging in the epidermal layer of the skin using cultured keratinocytes. Normal human epidermal keratinocytes were irradiated or left unirradiated with UV-B (10 mJ/cm2 ) and incubated with ETAS (0.5 or 2 mg/mL) or vehicle. After 3 or 13 h, molecular examinations were performed, and after 24 or 48 h, cell viabilities were determined by a CCK-8 assay...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29705807/rapamycin-protects-skin-fibroblasts-from-ultraviolet-b-induced-photoaging-by-suppressing-the-production-of-reactive-oxygen-species
#19
Dengke Qin, Runjian Ren, Chuanlong Jia, Yongzhou Lu, Qingjian Yang, Liang Chen, Xinyuan Wu, Jingjing Zhu, Yu Guo, Ping Yang, Yiqun Zhou, Ningwen Zhu, Bo Bi, Tianyi Liu
BACKGROUND/AIMS: Ultraviolet B (UVB) irradiation alters multiple molecular pathways in the skin, thereby inducing skin photoaging. Murine dermal fibroblasts (MDFs) were subjected to a series of 4 sub-cytotoxic UVB doses (120 mJ/cm2), resulting in changes in cell shape, DNA damage, cell cycle arrest, extracellular matrix variations, reactive oxygen species (ROS) generation, and alterations in major intracellular antioxidant and cellular autophagy levels. Rapamycin (RAPA) is a new macrolide immunosuppressive agent that is primarily used in oncology, cardiology, and transplantation medicine and has been found to extend the lifespan of genetically heterogeneous mice...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29704456/tretinoin-0-05-cream-vs-5-peel-for-photoaging-and-field-cancerization-of-the-forearms-randomized-evaluator-blinded-clinical-trial
#20
J M Sumita, H A Miot, J L M Soares, A C P Raminelli, S M Pereira, M M Ogawa, F R Picosse, L R S Guadanhim, M M S S Enokihara, G R Leonardi, E Bagatin
BACKGROUND: Topical tretinoin cream is the gold standard treatment for skin ageing, particularly photoaging. The purpose of tretinoin peel was to obtain similar results, but in a shorter time, however, there have been few controlled trials on its effectiveness. OBJECTIVE: To compare efficacy and safety of tretinoin 0.05% cream and 5% as a peeling agent on photoaging and field cancerization of the forearms. METHODS: Clinical trial with therapeutic intervention, prospective, randomized (computer-generated randomization list), parallel, comparative (intrasubject) and evaluator-blinded (except for histology and immunohistochemistry), including 24 women (48 forearms) aged over 60 years who have not undergone hormone replacement and categorized as Fitzpatrick skin phototype II or III...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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