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Photoageing

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https://www.readbyqxmd.com/read/29457847/preconditioning-with-low-level-laser-irradiation-enhances-the-therapeutic-potential-of-human-adipose-derived-stem-cells-in-a-mouse-model-of-photoaged-skin
#1
Xuan Liao, Sheng-Hong Li, Guang-Hui Xie, Shan Xie, Li-Ling Xiao, Jian-Xing Song, Hong-Wei Liu
The present study was conducted to explore the therapeutic potential of human adipose-derived stem cells (ADSCs) irradiated with a low level laser (LLL). Cultured ADSCs were treated with 650-nm GaAlAs laser irradiation at 2, 4, and 8 J/cm2 . Cell proliferation was quantified by MTT assays, cytokine secretion was determined by enzyme-linked immunosorbent assays, and adipogenic differentiation was examined by oil red O staining. Additionally, the expression profiles of putative ADSC surface markers were analyzed by quantitative real-time PCR...
February 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29446095/orobanche-cernua-loefling-attenuates-ultraviolet-b-mediated-photoaging-in-human-dermal-fibroblasts
#2
Wei Gao, Yu-Shuai Wang, Zheng-Yi Qu, Eunson Hwang, Hien T T Ngo, Ying-Ping Wang, Jahyun Bae, Tae-Hoo Yi
UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents have become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs)...
February 15, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29438574/protective-effects-of-an-extract-of-the-freshwater-microalga-scenedesmus-rubescens-on-uv-irradiated-skin-cells
#3
Remo Campiche, Petra Sandau, Elke Kurth, Marco Massironi, Dominik Imfeld, Rolf Schuetz
BACKGROUND: Skin aging results from intrinsic but also extrinsic factors of which UV-irradiation is a main cause. It is hence of interest to have means to protect skin from UV -irradiation induced damage. We selected an extract of the freshwater microalga Scenedesmus rubescens and assessed its potential to protect skin from photoaging caused by UV-irradiation. METHODS: Skin cells in-vitro and ex-vivo were analyzed for markers of UV-irradiation induced photodamage such as decreased viability, decreased collagen content, hyperpigmentation, and sunburn cells...
February 13, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29433674/protective-effect-of-dietary-alchemilla-mollis-on-uvb-irradiated-premature-skin-aging-through-regulation-of-transcription-factor-nfatc1-and-nrf2-are-pathways
#4
Eunson Hwang, Hien T T Ngo, Seul A Seo, Bom Park, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Alchemilla mollis (lady's mantle) is a common ingredient in skin care products. However, the protective mechanism of A. mollis against skin problems has not been elucidated. PURPOSE: This study was to investigate the effects of A. mollis ethanolic extract (AM) on UVB-irradiated normal human dermal fibroblasts (NHDF) and hairless mice. METHODS: The in vitro anti-photoaging effect of AM was performed in NHDFs. The antioxidant activities were assessed through DPPH, ABTS, and reactive oxygen species (ROS) assays...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29431281/remodeling-of-dermal-collagen-in-photoaged-skin-using-low-dose-5-aminolevulinic-acid-photodynamic-therapy-occurs-via-the-tgf-%C3%AE-pathway
#5
Peiru Wang, Jiatong Han, Minglei Wei, Yuting Xu, Guolong Zhang, Haiyan Zhang, Lei Shi, Xiaojing Liu, Michael R Hamblin, Xiuli Wang
5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is known to be effective in the treatment of photoaged skin. However, the molecular mechanisms still remain elusive. Protoporphyrin IX (PpIX) fluorescence is primarily located in the epidermis while ALA-PDT affects the dermal collagen, presumably by an indirect mechanism. This study aimed to investigate the molecular communication in low-dose ALA-PDT occurring between epidermal keratinocytes and dermal fibroblasts. Western blotting and enzyme-linked immunosorbent assays were performed to evaluate collagen expression and transforming growth factor-β (TGF-β) signaling in human keratinocytes and dermal fibroblasts...
February 12, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29422610/coordinated-activation-of-a-cluster-of-mmp-genes-in-response-to-uvb-radiation
#6
Zsuzsanna Ujfaludi, Agota Tuzesi, Hajnalka Majoros, Balint Rothler, Tibor Pankotai, Imre M Boros
Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, we use a novel human keratinocyte model, HKerE6SFM, to demonstrate that UVB activates the transcription of most members of the 11q22.3 MMP gene cluster including MMP13, MMP12, MMP3, MMP1 and MMP10...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421853/anti-photoaging-effect-of-prunus-yeonesis-blossom-extract-via-inhibition-of-mapk-ap-1-and-regulation-of-the-tgf-%C3%AE-i-smad-and-nrf2-are-signaling-pathways
#7
Lu Li, Eunson Hwang, Hien T T Ngo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi
Cherry blossoms have attracted attention as an ingredient with potential for use in skincare products. However, no skin photoaging-related research has been performed with this plant. In the present study, cherry blossom extract (CBE) at 1, 10, and 100 μg/mL was investigated for its skin anti-photoaging effects in UVB-irradiated normal human dermal fibroblasts (NHDF) cells in vitro. Our results showed that CBE markedly increased type I procollagen during UVB exposure via two pathways. Firstly, transcription activator protein-1 expression and MAP kinases were downregulated, consequently reducing the production of matrix metalloproteinase (MMP)-1 and MMP-3...
February 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29421845/effects-of-repeated-uva-irradiation-on-human-skin-fibroblasts-embedded-in-3d-tense-collagen-matrix
#8
Wongnapa Nakyai, Marion Tissot, Philippe Humbert, François Grandmottet, Jarupa Viyoch, Céline Viennet
Skin photoaging is caused by cumulative UVA exposure that leads to dermal matrix alterations associated with impaired fibroblast functions. In this study, we evaluated the effects of repeated UVA irradiation on mechanically stressed fibroblasts which were embedded in 3D tense collagen matrix. By comparison to 2D monolayer culture, we investigated the expressions of alpha smooth muscle actin (α-SMA) cytoskeleton and α2 subunit of integrin receptors, as well as the collagen metabolism, focusing to MMP-1 and collagen type I expressions...
February 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29399294/topical-or-oral-treatment-of-peach-flower-extract-attenuates-uv-induced-epidermal-thickening-matrix-metalloproteinase-13-expression-and-pro-inflammatory-cytokine-production-in-hairless-mice-skin
#9
Chung Shil Kwak, Jiwon Yang, Chang-Yup Shin, Jin Ho Chung
BACKGROUND/OBJECTIVES: Ultraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29395579/trans-cinnamic-acid-attenuates-uva-induced-photoaging-through-inhibition-of-ap-1-activation-and-induction-of-nrf2-mediated-antioxidant-genes-in-human-skin-fibroblasts
#10
You-Cheng Hseu, Mallikarjuna Korivi, Fang-Ying Lin, Mei-Ling Li, Ruei-Wan Lin, Jia-Jiuan Wu, Hsin-Ling Yang
BACKGROUND: UVA irradiation-induced skin damage/photoaging is associated with redox imbalance and collagen degradation. OBJECTIVE: Dermato-protective efficacies of trans-cinnamic acid (t-CA), a naturally occurring aromatic compound have been investigated against UVA irradiation, and elucidated underlying molecular mechanism. METHODS: Human foreskin fibroblast-derived (Hs68) cells and nude mice were treated with t-CA prior to UVA exposure, and assayed the anti-photoaging effects of t-CA...
January 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29394139/longitudinal-evaluation-of-radiopacity-of-resin-composites-influence-of-photoactivation-and-accelerated-photoaging
#11
A D Cruz, Iam Costa, F S Calazans, M F Aguiar, M O Barceleiro
This study aimed to assess longitudinally the radiopacity of resin composites under the influence of photoactivation and photoaging processes. Ten specimens (1 mm thick and 4 mm in diameter) of three different microhybrid resin composites, Filtek Z250 XT (R1), TPH 3 Spectrum (R2), and Opallis (R3), were prepared for this study. For longitudinal assessment of radiopacity, radiographic images were obtained five times. The first time (T1), the specimens were not photoactivated; the second time (T2), the specimens were photoactivated; and the next three times, photoaging was carried out, with images obtained at 24 hours (T3), 48 hours (T4), and 72 hours (T5) after this process...
February 2, 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29382339/the-flavonoid-hesperidin-exerts-anti-photoaging-effect-by-downregulating-matrix-metalloproteinase-mmp-9-expression-via-mitogen-activated-protein-kinase-mapk-dependent-signaling-pathways
#12
Hee Jeong Lee, A-Rang Im, Su-Man Kim, Hyung-Sik Kang, Jae Dong Lee, Sungwook Chae
BACKGROUND: Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation. This study was designed to evaluate the efficacy of hesperidin against photoaging of dorsal skin in hairless mice. METHODS: Hairless male mice (6-week-old) were divided into three groups (n = 7): control, UVB-treated vehicle, and UVB-treated hesperidin groups. UVB-irradiated mice from hesperidin group were orally administered 0...
January 30, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29380024/nanofat-increases-dermis-thickness-and-neovascularization-in-photoaged-nude-mouse-skin
#13
Peng Xu, Qian Yu, Huizhen Huang, Wen Jie Zhang, Wei Li
OBJECT: To investigate the effects of nanofat injection into photoaged nude mouse skin on dermis thickness, neovascularization, and cell proliferation. METHODS: Adipose-derived stem cells (ADSCs) and nanofat were prepared from human liposuction aspirates. The photoaged skin model was created using ultraviolet B (UVB) radiation onto BALB/c nude mice. A total of 24 mice were used in this study; 6 mice without treatment (natural aging) served as controls, while 18 mice were irradiated under the UVB lamp and treated with PBS (200 μl per injection area), ADSCs (1 × 106/200 μl ADSCs per injection area), or nanofat (200 μl per injection area) on the dorsal skin...
January 29, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29360654/commentary-on-punctuated-88-phenol-peeling-for-the-treatment-of-facial-photoaging
#14
Harold J Brody
No abstract text is available yet for this article.
January 22, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29356271/assessment-of-the-efficacy-and-tolerance-of-an-innovative-regenerative-serum-on-cutaneous-regeneration-following-fractional-laser-procedure-using-erbium-yag
#15
Natalia Jiménez, Angela Hermosa, Laura de Miguel, Natalia Sánchez-Neila, Maria Teresa Truchuelo, Itziar Eraña, Jesus Cuevas
INTRODUCTION: Cutaneous regeneration, fractional laser, medical device, cellular proliferation cutaneous changes linked to photoaging are currently treated with physical treatments, such as fractional laser, which may induce epidermal alteration. OBJECTIVE: To determine the efficacy and safety of a regenerative serum (Matricium® , Laboratoire Bioderma, France) after laser procedure. METHODS: Prospective, double-blind, controlled, and randomized study in subjects with photoaged skin...
January 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29356215/appearance-based-interventions-to-reduce-uv-exposure-a-systematic-review
#16
Sofia Persson, Yael Benn, Katie Dhingra, David Clark-Carter, Alison L Owen, Sarah Grogan
PURPOSE: As a majority of skin cancer cases are behaviourally preventable, it is crucial to develop effective strategies to reduce UV exposure. Health-focused interventions have not proved to be sufficiently effective, and it has been suggested that people might be more susceptible to information about the negative effects of the sun on their appearance. METHOD: This systematic review of 30 separate papers, reporting 33 individual studies published between 2005 and 2017, assesses the overall effectiveness of appearance interventions on participants' UV exposure and sun protection behaviour...
January 22, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29353733/in-vitro-evaluation-of-antioxidant-anti-elastase-anti-collagenase-anti-hyaluronidase-activities-of-safranal-and-determination-of-its-sun-protection-factor-in-skin-photoaging
#17
Kumud Madan, Sanju Nanda
Safranal, a monoterpene aldehyde, is present as one of the main volatile constituents of Crocus sativus Linn. (saffron flowers). This volatile constituent not only contributes to the aroma of saffron but has been reported to possess antidiabetic, antiulcer, antiasthamatic, anticonvulsant, antidepressant, cardioprotective, anticancer and UV protective properties. Most of these therapeutic actions are contributed by its potential to quench reactive oxygen species (ROS). Antioxidant properties of phytoconstituents are now being explored for developing photoprotective skin formulations...
January 4, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29353331/construction-of-a-plasmid-vector-containing-epidermal-growth-factor-receptor-and-c-jun-shrna
#18
Hong Xiao, Ruinian Yang, Fang Yang, Yanan Zhao, Yin Liu
The objective of this study was to construct a plasmid vector for EGFR-hm-1 and C-Junh-825 small interfering RNA (siRNA). EGFR-hm-1 and C-Jun-hm-825 oligonucleotide fragments were synthesized and short hairpin RNA (shRNA) were amplified by PCR. Plasmids were isolated from E. coli TOP10 bacterium by restriction enzyme digestion using pst1 and BamH1 and oligonucleotide fragments were cloned into the pSilencer plasmid containing the U6 promoter. Recombinant clones were generated by transforming JM109 competent cells with plasmid vectors containing shRNA molecules...
January 20, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29348726/photoaging-protective-effects-of-biogf1k-a-compound-k-rich-fraction-prepared-from-panax-ginseng
#19
Yo Han Hong, Donghyun Kim, Gibaeg Nam, Sulgi Yoo, Sang Yun Han, Seong-Gu Jeong, Eunji Kim, Deok Jeong, Keejung Yoon, Sunggyu Kim, Junseong Park, Jae Youl Cho
Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29341894/protective-effects-of-antioxidin-rl-from-odorrana-livida-against-ultraviolet-b-irradiated-skin-photoaging
#20
Di Qin, Wen-Hui Lee, Zhiqin Gao, Weifen Zhang, Meiyu Peng, Tongyi Sun, Yuanyuan Gao
The unavoidable daily exposure of the skin to ultraviolet (UV) B radiation is proven to have deleterious effects. The action mechanism of antioxidin-RL, an antioxidant peptide purified from skin secretions of frog Odorrana livida with amino acid sequence of AMRLTYNRPCIYAT, is well characterized by NMR titration and mutation based on ABTS+ scavenging activities. In order to explore the protective effects of antioxidin-RL against UVB-irradiated skin photoaging, cell uptake assay was used to detect the location of antioxidin-RL molecules serving various biological functions in the cells...
January 13, 2018: Peptides
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