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Photoageing

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https://www.readbyqxmd.com/read/27901001/ultraviolet-a-enhances-cathepsin-l-expression-and-activity-via-jnk-pathway-in-human-dermal-fibroblasts
#1
Qing-Fang Xu, Yue Zheng, Jian Chen, Xin-Ya Xu, Zi-Jian Gong, Yun-Fen Huang, Chun Lu, Howard I Maibach, Wei Lai
BACKGROUND: Cathepsin L (CatL) is a cysteine protease with strong matrix degradation activity that contributes to photoaging. Mannose phosphate-independent sorting pathways mediate ultraviolet A (UVA)-induced alternate trafficking of CatL. Little is known about signaling pathways involved in the regulation of UVA-induced CatL expression and activity. This study aims to investigate whether a single UVA irradiation affects CatL expression and activity and whether mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) pathway is involved in the regulation of UVA-induced CatL expression and activity in human dermal fibroblasts (HDFs)...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27880964/protective-effects-of-standardized-siegesbeckia-glabrescens-extract-and-its-active-compound-kirenol-against-uvb-induced-photoaging-through-inhibition-of-mapk-nf-%C3%AE%C2%BAb-pathways
#2
Jongwook Kim, Mi-Bo Kim, Jun Gon Yun, Jae Kwan Hwang
Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day) showed reduced wrinkle formation and skinfold thickness compared to the UVB-irradiated control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes (COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase), while suppressing the matrix metalloproteinases (MMPs; MMP-2, -3, -9, and -13) expression...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27876133/skin-phenotypes-can-offer-some-insight-about-the-association-between-telomere-length-and-cancer-susceptibility
#3
S Ribero, M Mangino, V Bataille
The role of telomere biology in cancer has been studied for a wide variety of different cancers but the association with telomere length has been controversial. This is because some cancers have been found to be associated with longer telomeres in circulating white cells whilst other cancer types are more common in individuals with shorter telomeres. Hence, there has been some skepticism as to whether telomere length may be helpful in estimating cancer risk. For melanoma, however, results have been fairly consistent showing that longer telomeres are associated with an increased risk...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27864996/skin-microtopography-as-a-measure-of-photoaging-and-risk-of-squamous-cell-carcinoma-of-the-skin-in-a-us-population
#4
L F Kuklinski, M S Zens, A E Perry, A C Green, M R Karagas
BACKGROUND: Skin microtopography as a measure of photoaging is a non-invasive approach to measuring chronic ultraviolet radiation (UVR) exposure, and reflects the degree of dermal elastosis in populations of European descent in the subtropics. Less is known about the utility of this approach in populations at different latitudes, and whether it relates to skin cancer risk. METHODS: A population-based case-control study of 342 SCC cases and 331 age- and gender-matched controls were evaluated for histologic evidence of solar damage and severity of photoaging based on microtopography on a six-grade scale...
November 19, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27861965/impact-of-the-circadian-clock-on-uv-induced-dna-damage-response-and-photocarcinogenesis
#5
Panshak Dakup, Shobhan Gaddameedhi
The skin is in constant exposure to various external environmental stressors, including solar ultraviolet (UV) radiation. Various wavelengths of UV light are absorbed by the DNA and other molecules in the skin to cause DNA damage and induce oxidative stress. The exposure to excessive ultraviolet (UV) radiation and/or accumulation of damage over time can lead to photocarcinogenesis and photoaging. The nucleotide excision repair (NER) system is the sole mechanism for removing UV photoproduct damage from DNA, and genetic disruption of this repair pathway leads to the photosensitive disorder xeroderma pigmentosum (XP)...
November 12, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27854351/a-mixture-of-extracts-of-kochia-scoparia-and-rosa-multiflora-with-ppar-%C3%AE-%C3%AE-dual-agonistic-effects-prevents-photoaging-in-hairless-mice
#6
Hyerin Jeon, Dong Hye Kim, Youn-Hwa Nho, Ji-Eun Park, Su-Nam Kim, Eung Ho Choi
Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as Kochia scoparia and Rosa multiflora, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm² and UVB 40 mJ/cm² three times a week for 8 weeks...
November 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27854199/chyawanprash-a-formulation-of-traditional-ayurvedic-medicine-shows-a-protective-effect-on-skin-photoaging-in-hairless-mice
#7
Yuki Takauji, Kyoko Morino, Kensuke Miki, Mohammad Hossain, Dai Ayusawa, Michihiko Fujii
OBJECTIVE: Chronic exposure to ultraviolet (UV) radiation induces skin photoaging (premature skin aging). UV irradiation generates reactive oxygen species (ROS), which are shown to play a pivotal role in skin photoaging. Ayurveda is a holistic traditional medical system, and Chyawanprash is one of the most popular formulations in Ayurveda. Since maintenance of the function and appearance of skin is important, we examined whether Chyawanprash has a protective effect on skin photoaging...
November 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27847821/djulis-chenopodium-formosanum-koidz-water-extract-and-its-bioactive-components-ameliorate-dermal-damage-in-uvb-irradiated-skin-models
#8
Yong-Han Hong, Ya-Ling Huang, Yao-Cheng Liu, Pi-Jen Tsai
Dermal photoaging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photoaging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 μg/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27847530/aqueous-extract-of-clerodendranthus-spicatus-exerts-protective-effect-on-uv-induced-photoaged-mice-skin
#9
Lan Wang, Xie Zhang, Yong-Xian Li, Lie-Qiang Xu, Cai-Lan Li, Zhen-Biao Zhang, Jia-Li Liang, Zi-Ren Su, Hui-Fang Zeng, Yu-Cui Li
Clerodendranthus spicatus (Thunb.) C.Y.Wu (CS) is commonly used to treat kidney diseases in traditional Chinese medicine for its prominent anti-inflammatory effect and nourishing function to kidneys. In this study, aqueous extract of CS was assessed for its protective effect on UV-induced skin damage of mice. The chemical compositions of CS aqueous extract were determined by HPLC-ESI-MS/MS, in which 10 components were identified. During the experimental period, CS (0.9, 1.8, and 3.6 g/mL) was externally applied to shaved dorsal skins of mice prior to UV irradiation, daily for ten weeks...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27821601/photoaging-smartphone-app-promoting-poster-campaign-to-reduce-smoking-prevalence-in-secondary-schools-the-smokerface-randomized-trial-design-and-baseline-characteristics
#10
Titus J Brinker, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Fabian N Fries, Hannah Spielmann, Nancy Rigotti, Werner Seeger, Felix Herth, David A Groneberg, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Anil Batra, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas, Ute Mons, Michael Kreuter
INTRODUCTION: Smoking is the largest cause of preventable death globally. Most smokers smoke their first cigarette in early adolescence. We took advantage of the widespread availability of mobile phones and adolescents' interest in appearance to develop a free photoaging app which is promoted via a poster campaign in secondary schools. This study aims to evaluate its effectiveness regarding smoking prevalence and students' attitudes towards smoking. METHODS AND ANALYSIS: A randomised controlled trial is conducted with 9851 students of both genders with an average age of 12 years in grades 6 and 7 of 126 secondary schools in Germany...
November 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27816646/hesperidin-ameliorates-uv-radiation-induced-skin-damage-by-abrogation-of-oxidative-stress-and-inflammatory-in-hacat-cells
#11
Min Li, Xiang-Fei Lin, Jie Lu, Bing-Rong Zhou, Dan Luo
Ultraviolet A (UVA) radiation contributes to skin photoaging. Hesperidin which is a flavanone glycoside found in citrus fruit peels, have been intensively studied for their UVA-protective activity, but its effects and mechanisms on UVA irradiation-induced inflammation and oxidative stress have never been described. Thus, the purpose of this study was to evaluate the effects of hesperidin in skin oxidative stress and inflammation induced by UVA irradiation. In this study, we firstly examined whether hesperidin may exert direct protective effects on the UVA-induced in human keratinocytes (HaCaT) cell injury in vitro...
November 1, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27816645/stereospecificity-of-ginsenoside-rg2-epimers-in-the-protective-response-against-uv-b-radiation-induced-oxidative-stress-in-human-epidermal-keratinocytes
#12
Hyun-Ji Kang, Yu-Hua Huang, Hye-Won Lim, Daehyun Shin, Kyounghee Jang, Yoonjin Lee, Kyunghoon Kim, Chang-Jin Lim
Ginseng, referring to the dried roots of Panax ginseng C.A. Meyer, has been known as a famous traditional folkloric medicine in East Asian countries for a long time. In recent years, it has been gaining a worldwide popularity as a dietary herbal supplement. Ginsenosides are bioactive ingredients that are responsible for most pharmacological efficacies of ginseng. Ginsenoside Rg2 (Rg2), one of minor protopanaxatriol (PPT)-type ginsenosides, exists in two epimeric forms, 20(S)-ginsenoside Rg2 [20(S)-Rg2] and 20(R)-ginsenoside Rg2 [20(R)-Rg2]...
October 29, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27794421/a-topical-mitochondria-targeted-redox-cycling-nitroxide-mitigates-oxidative-stress-induced-skin-damage
#13
Rhonda M Brand, Michael W Epperly, J Mark Stottlemyer, Erin M Skoda, Xiang Gao, Song Li, Saiful Huq, Peter Wipf, Valerian E Kagan, Joel S Greenberger, Louis D Falo
Skin is the largest human organ and provides a first line of defense that includes physical, chemical, and immune mechanisms to combat environmental stress. Radiation is a prevalent environmental stressor. Radiation induced skin damage ranges from photoaging and cutaneous carcinogenesis from UV exposure, to treatment-limiting radiation dermatitis associated with radiotherapy, to cutaneous radiation syndrome, a frequently fatal consequence of exposures from nuclear accidents. The major mechanism of skin injury common to these exposures is radiation induced oxidative stress...
October 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27781390/a-multicenter-placebo-controlled-double-blind-clinical-trial-assessing-the-effects-of-a-multicomponent-nutritional-supplement-for-treating-photoaged-skin-in-healthy-women
#14
Jay E Birnbaum, David H McDaniel, Janet Hickman, Lisa Dispensa, Anne Le Moigne, Larry Buchner
BACKGROUND: Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. AIMS: Evaluate a multicomponent nutritional supplement on photoaged skin. PATIENTS/METHODS: This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatrick skin types I-IV and Glogau classification types II-III to a multicomponent nutritional supplement or placebo for 24 weeks...
October 25, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27774902/ginseng-in-dermatology-a-review
#15
Sarvenaz Sabouri-Rad, Sara Sabouri-Rad, Amirhossein Sahebkar, Zahra Tayarani-Najaran
Ginseng has gained fame as one of the most popular herbs originating from Eastern countries. Among different species which are known as ginseng, Panax ginseng C. A. Mey. (Korean or Asian ginseng) is the most frequently used one. Ginsenosides have been proposed to account for most of the biological activities of ginseng. The widely appreciated health-promoting effect of ginseng pertains to the beneficial effects of this plant against immune, cardiovascular and sexual diseases and cancer. In addition, there are some new aspects of the pharmacological activity of this plant which justify its use in dermatologic diseases...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27768951/protective-effect-of-gelatin-peptides-from-pacific-cod-skin-against-photoaging-by-inhibiting-the-expression-of-mmps-via-mapk-signaling-pathway
#16
Tiejun Chen, Hu Hou, Yan Fan, Shikai Wang, Qianru Chen, Leilei Si, Bafang Li
Chronic exposure to ultraviolet (UV) irradiation causes skin photoaging. This study was undertaken to identify the anti-photoaging mechanisms of gelatin hydrolysate (CH) derived from pacific cod skin. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and ELISA assays were used to investigate the effects of CH on matrix metalloproteinases (MMPs) and the signaling pathways after UV irradiation by using a mice skin photoaging model. The average molecular weight of CH was 1200Da, and 273/1000 residues were hydrophobic, Gly-Pro and Gly-Leu sequences and Arg at C-terminus appeared frequently in CH...
October 14, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27765346/dietary-foeniculum-vulgare-mill-extract-attenuated-uvb-irradiation-induced-skin-photoaging-by-activating-of-nrf2-and-inhibiting-mapk-pathways
#17
Zhengwang Sun, Sang Yong Park, Eunson Hwang, Bom Park, Seul A Seo, Jin-Gyeong Cho, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging PURPOSE: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo. METHODS: The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-β1 (TGF-β1) were measured by kits...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27749441/daily-use-of-a-facial-broad-spectrum-sunscreen-over-one-year-significantly-improves-clinical-evaluation-of-photoaging
#18
Manpreet Randhawa, Steven Wang, James J Leyden, Gabriela O Cula, Alessandra Pagnoni, Michael D Southall
BACKGROUND: Sunscreens are known to protect from sun damage; however, their effects on the reversal of photodamage have been minimally investigated. OBJECTIVE: The aim of the prospective study was to evaluate the efficacy of a facial sun protection factor (SPF) 30 formulation for the improvement of photodamage during a 1-year use. METHODS: Thirty-two subjects applied a broad spectrum photostable sunscreen (SPF 30) for 52 weeks to the entire face...
October 4, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27732760/daily-ingestion-of-aloe-vera-gel-powder-containing-aloe-sterols-prevents-skin-photoaging-in-ovx-hairless-mice
#19
Ruiqing Yao, Miyuki Tanaka, Eriko Misawa, Marie Saito, Kazumi Nabeshima, Koji Yamauchi, Fumiaki Abe, Yuki Yamamoto, Fukumi Furukawa
Estrogen deficiencies associated with menopause accelerate spontaneous skin aging and stimulate the ultraviolet (UV) irradiation-induced photoaging of skin. However, food compositions with the potential to ameliorate the UV irradiation-induced acceleration of skin aging with menopause have not yet been investigated in detail. In the present study, we examined the ability of plant sterols derived from Aloe vera gel to prevent the UV irradiation-induced acceleration of skin aging in ovariectomized mice. Skin transepidermal water loss (TEWL) was significantly higher in the ovariectomy group than in the sham operation group following UVB irradiation, whereas skin elasticity was significantly lower...
October 12, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27731897/elastin-structure-and-its-involvement-in-skin-photoaging
#20
A C Weihermann, M Lorencini, C A Brohem, C M de Carvalho
Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers...
October 12, 2016: International Journal of Cosmetic Science
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