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Photoageing

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https://www.readbyqxmd.com/read/29040421/effect-of-use-of-platelet-rich-plasma-prp-in-skin-with-intrinsic-aging-process
#1
Luiz Charles-de-Sá, Natale Ferreira Gontijo-de-Amorim, Christina Maeda Takiya, Radovan Borojevic, Donatella Benati, Paolo Bernardi, Andrea Sbarbati, Gino Rigotti
Background: In previous papers, we demonstrated that the treatment of human photoaged skin with stromal-vascular fraction-enriched fat or expanded adipose-derived stem cells showed a decrease of elastosis and the appearance of new oxytalan elastic fibers in dermis and an increase in the vascular network. The utilization of fat plus platelet-rich plasma (PRP) led to an increase in the vascular permeability and reactivity of the nervous component. Objectives: The purpose of this study was to analyze the histologic and ultrastructural changes of human skin after the injection of only PRP in the retroauricular area that was not exposed to sun and did not present the photoaging process, in comparison with our previous results...
September 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29021691/photoprotective-effects-of-topical-ginseng-leaf-extract-using-ultraflo-l-against-uvb-induced-skin-damage-in-hairless-mice
#2
Yang Hee Hong, Hyun-Sun Lee, Eun Young Jung, Sung-Hee Han, Yooheon Park, Hyung Joo Suh
BACKGROUND: Abnormal activation of matrix metalloproteinases (MMPs) plays an important role in UV-induced wrinkle formation, which is a major dermatological problem. This formation occurs due to the degeneration of the extracellular matrix (ECM). In this study, we investigated the cutaneous photoprotective effects of Ultraflo L treated ginseng leaf (UTGL) in hairless mice. METHODS: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28988108/salubrinal-protects-human-skin-fibroblasts-against-uvb-induced-cell-death-by-blocking-endoplasmic-reticulum-er-stress-and-regulating-calcium-homeostasis
#3
Chao Ji, Bo Yang, Shu-Ying Huang, Jin-Wen Huang, Bo Cheng
The role of UVB in skin photo damages has been widely reported. Overexposure to UVB will induce severe DNA damages in epidermal cells and cause most cytotoxic symptoms. In the present study, we tested the potential activity of salubrinal, a selective inhibitor of Eukaryotic Initiation Factor 2 (eIF2) -alpha phosphatase, against UV-induced skin cell damages. We first exposed human fibroblasts to UVB radiation and evaluated the cytosolic Ca(2+) level as well as the induction of ER stress. We found that UVB radiation induced the depletion of ER Ca(2+) and increased the expression of ER stress marker including phosphorylated PERK, CHOP, and phosphorylated IRE1α...
October 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28979661/a-prospective-pilot-clinical-trial-to-evaluate-the-efficacy-and-safety-of-topical-therapy-with-ingenol-mebutate-gel-0-015-for-actinic-keratosis-on-an-expanded-area-of-the-chest
#4
Douglas C Wu, Isabella Guiha, Mitchel P Goldman
BACKGROUND: Ingenol mebutate gel 0.05% once daily for two consecutive days provides high clearance rates for actinic keratosis on a 25cm(2) area of the chest. However, it may cause intense local skin responses. OBJECTIVE: The objective of this study was to determine whether a lower dose of ingenol mebutate gel 0.015% could clear actinic keratosis on the chest with acceptable tolerability and a possible beneficial effect on photodamage and cosmesis. DESIGN: This was a noncomparative, open-label study (NCT02446223)...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28962194/polycomb-group-proteins-novel-molecules-associated-with-ultraviolet-a-induced-photoaging-of-human-skin
#5
Zhuoxia Wu, Lianbo Zhang
Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI-1 and EZH2) were altered...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28948464/enhancement-of-protective-effects-of-radix-scutellariae-on-uvb-induced-photo-damage-in-human-hacat-keratinocytes
#6
Yu-Shuai Wang, Jin-Gyeong Cho, Eun-Son Hwang, Jung-Eun Yang, Wei Gao, Min-Zhe Fang, Sheng-Dao Zheng, Tae-Hoo Yi
Radix Scutellariae (RS) has long been used in the treatment of inflammatory and allergic diseases. Its main flavonoids, baicalin (BG) and wogonoside (WG), can be hydrolyzed into their corresponding aglycones, baicalein (B) and wogonin (W). In this study, we developed a safe and effective method of transforming these glycosides using Peclyve PR. The transformation rate of BG and WG reached 98.5 and 98.1%, respectively, with 10% enzyme at 40 °C for 60 h. Furthermore, we compared the anti-photoaging activity of RS before and after enzyme treatment, as well as their respective main components, in UVB-irradiated HaCaT cells...
September 26, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28946661/anti-photoaging-effect-of-jeju-putgyul-unripe-citrus-extracts-on-human-dermal-fibroblasts-and-ultraviolet-b-induced-hairless-mouse-skin
#7
Seung-Hyun Choi, Sun-Il Choi, Tae-Dong Jung, Bong-Yeon Cho, Jin-Ha Lee, Seung-Hyung Kim, Seon-A Yoon, Young-Min Ham, Weon-Jong Yoon, Ju-Hyun Cho, Ok-Hawn Lee
Ultraviolet (UV) radiation stimulates the expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. These signaling pathways participate in the degradation of the extracellular matrix and induce inflammatory responses that lead to photoaging. This study evaluated the antioxidant activity and the effect on MMPs and procollagen of putgyul extract in vitro. The anti-photoaging activity of putgyul extracts was estimated in vivo using hairless mice (HR-1). The putgyul extracts reduced MMP-1 production and increased the content of procollagen type I carboxy-terminal peptide in human dermal fibroblasts...
September 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28935619/a-dermatologist-s-ammunition-in-the-war-against-smoking-a-photoaging-app
#8
Titus Josef Brinker, Alexander Enk, Martina Gatzka, Yasuhiro Nakamura, Wiebke Sondermann, Albert Joachim Omlor, Maximilian Philip Petri, Ante Karoglan, Werner Seeger, Joachim Klode, Christof von Kalle, Dirk Schadendorf
This viewpoint reviews the perspectives for dermatology as a specialty to go beyond the substantial impact of smoking on skin disease and leverage the impact of skin changes on a person's self-concept and behavior in the design of effective interventions for smoking prevention and cessation.
September 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28917186/compounds-isolated-from-eriobotrya-deflexa-leaves-protect-against-ultraviolet-radiation-b-induced-photoaging-in-human-fibroblasts
#9
Chung-Yu Huang, Yi-Tzu Lin, Hsiang-Chun Kuo, Wen-Fei Chiou, Mei-Hsien Lee
Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have demonstrated that an E. deflexa leaf extract functions as a free radical scavenger. The current evaluated the antiphotoaging effect of partitioned fractions and specific compounds from the leaves of E...
October 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28906033/collagen-peptides-modulates-the-metabolism-of-extracellular-matrix-by-human-dermal-fibroblasts-derived-from-sun-protected-and-sun-exposed-body-sites
#10
Vivian Zague, Jonatas Bussador do Amaral, Paula Rezende Teixeira, Evandro Luis de Oliveira Niero, Camila Lauand, Glaucia Maria Machado-Santelli
Clinical data published in recent years has demonstrated positive effects of collagen hydrolysate (CH) on skin aging clinical signs. CH use as food supplement has a long history; however, few studies have addressed the underlying purpose of CH on the cellular and molecular biology of skin cells that could elucidate clinical improvement findings. Wide diversity of characteristics has been reported for dermal fibroblasts derived from different body sites and it is unknown whether collagen peptides could modulate differently cells from chronological aged and photoaged skin areas...
September 14, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28902035/small-particle-hyaluronic-acid-gel-treatment-of-photoaged-hands
#11
Eric C Wilkerson, David J Goldberg
BACKGROUND: Aging hands tend to lose subcutaneous volume resulting in prominence of the underlying vessels, tendons, and bone contributing to an aged appearance. Dermal fillers have been successfully used to improve the appearance of the aging dorsal hand. OBJECTIVE: The objective is to evaluate the safety and efficacy of a small-particle hyaluronic acid (SPHA) injectable gel for the treatment of photoaged volume loss of the hands. MATERIALS AND METHODS: This is an open-label, prospective, randomized, interventional, study...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28900534/resveratrol-enriched-rice-attenuates-uvb-ros-induced-skin-aging-via-downregulation-of-inflammatory-cascades
#12
Lalita Subedi, Taek Hwan Lee, Hussain Mustatab Wahedi, So-Hyeon Baek, Sun Yeou Kim
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28895754/coenzyme-q10-and-retinaldehyde-co-loaded-nanostructured-lipid-carriers-for-efficacy-evaluation-in-wrinkles
#13
Kritika Nayak, Sameer S Katiyar, Varun Kushwah, Sanyog Jain
The present study depicts coenzyme Q10 (CoQ10) and retinaldehyde (RAL) co-loaded Nanostructured Lipid Carriers (NLCs); having activity on different targets of photoageing, which can overcome deficits of conventional topical dosage forms. The developed NLCs were characterized for particle size, polydispersity index, and % Entrapment efficiency, followed by their incorporation into Carbopol® 934P-NF gel. In vitro cellular uptake and cytotoxicity assay was performed to evaluate NLCs and in vivo study on UV induced wrinkle model to determine efficacy of NLCs...
September 12, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28887295/photoaging-mobile-apps-in-school-based-melanoma-prevention-pilot-study
#14
Titus Josef Brinker, Christian Martin Brieske, Christoph Matthias Schaefer, Fabian Buslaff, Martina Gatzka, Maximilian Philip Petri, Wiebke Sondermann, Dirk Schadendorf, Ingo Stoffels, Joachim Klode
BACKGROUND: Around 90% of melanomas are caused by exposure to ultraviolet (UV) radiation and are therefore eminently preventable. Tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to malignant melanoma and other skin cancers are too far in the future to fathom. Given the substantial amount of time children and adolescents spend in schools, as well as with their mobile phones, addressing melanoma prevention via both of these ways is crucial...
September 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28877312/effect-of-topical-fluorouracil-cream-on-photodamage-secondary-analysis-of-a-randomized-clinical-trial
#15
Kaveri Korgavkar, Kachiu C Lee, Martin A Weinstock
Importance: Photoaging, which is premature skin aging caused by long-term UV exposure, is of aesthetic concern to many patients. Objective: To investigate the effect of topical fluorouracil, 5%, cream on photoaging using validated photonumeric scales. Design, Setting, and Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized clinical trial of 932 US veterans with a recent history of 2 or more keratinocyte carcinomas performed from September 30, 2011, through June 30, 2014, to assess the chemopreventive effects of a standard course of topical fluorouracil...
September 6, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28873228/photodegradation-of-eumelanin-and-pheomelanin-and-its-pathophysiological-implications
#16
Shosuke Ito, Kazumasa Wakamatsu, Tadeusz Sarna
Eumelanin is photoprotective for pigmented tissues while pheomelanin is phototoxic. In this review, we summarize current understanding of how eumelanin and pheomelanin structures are modified by ultraviolet A (UVA) and also by visible light and how reactive oxygen species participate in those processes. Alkaline hydrogen peroxide oxidation was employed to characterize eumelanin and benzothiazole-type pheomelanin, giving pyrrole-2,3,5-tricarboxylic acid (PTCA) and thiazole-2,4,5-tricarboxylic acid (TTCA), respectively...
September 5, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28867806/how-stress-treatments-influence-the-performance-of-biodegradable-poly-butylene-succinate-based-copolymers-with-thioether-linkages-for-food-packaging-applications
#17
Valentina Siracusa, Laura Genovese, Andrea Munari, Nadia Lotti
Biodegradable poly(butylene succinate) (PBS)-based random copolymers containing thioether linkages (P(BSxTDGSy)) of various compositions have been investigated and characterized from the gas barrier, thermal, and mechanical point of view, after food contact simulants or thermal and photoaging processes. Each stress treatment was performed on thin films and the results obtained have been compared to the same untreated film, used as a standard. Barrier properties with different gases (O₂ and CO₂) were evaluated, showing that the polymer chemical composition strongly influenced the permeability behavior...
August 30, 2017: Materials
https://www.readbyqxmd.com/read/28865110/the-effect-of-photodamage-on-the-female-caucasian-facial-stratum-corneum-corneome-using-mass-spectrometry-based-proteomics
#18
Rainer Voegeli, Jean-Marc Monneuse, Rotraut Schoop, Beverley Summers, Anthony V Rawlings
BACKGROUND: The effect of photodamage on facial stratum corneum (SC) is still poorly understood. OBJECTIVE: To describe the SC proteome from tape strippings of Caucasian SC from photoexposed cheek and photoprotected post auricular (PA) site a global analysis of photodamage on the skin will be developed leading to a better understanding of keratinocyte signalling pathways and identification of new molecular targets for the treatment of photoaged skin. METHODS: Female Caucasian subjects had 9 consecutive tape strippings taken from their cheeks and PA site...
September 2, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28860083/fluorescence-spectroscopy-in-the-visible-range-for-the-assessment-of-uvb-radiation-effects-in-hairless-mice-skin
#19
Carolina de Paula Campos, Camila de Paula D'Almeida, Marcelo Saito Nogueira, Lilian Tan Moriyama, Sebastião Pratavieira, Cristina Kurachi
Ultraviolet (UV) radiation may induce skin alterations as observed in photoaging. Some recognized modifications are epidermal hyperplasia, amorphous deposition of degraded elastic fibers and reduction in the number of collagen fibers. They alter the tissue biochemical properties that can be interrogated by steady state fluorescence spectroscopy (SSFS). In this study, we monitored the changes in endogenous fluorescence emission from hairless mice skin during a protocol of photoaging using UVB irradiation. To perform the fluorescence spectroscopy, it was used a violet laser (408nm) to induce the native fluorescence that is emitted in the visible range...
August 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28858927/clinical-and-histologic-evaluation-of-ingenol-mebutate-0-015-gel-for-the-cosmetic-improvement-of-photoaged-skin
#20
Marc Z Handler, Bradley S Bloom, David J Goldberg
BACKGROUND: No studies have examined the use of topical ingenol mebutate for improvement of photoaged skin. OBJECTIVE: To evaluate clinical results of ingenol mebutate gel applied to photoaged skin and to quantify improvement at 7, 30, and 60 days after application. MATERIALS AND METHODS: Twenty-five subjects were enrolled in the study. Picato (ingenol mebutate) (LEO Pharma, Parsippany, NJ) gel was applied to an area with a known actinic keratosis daily for 3 days...
August 30, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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