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Photoageing

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https://www.readbyqxmd.com/read/29665401/coumestrol-hydroxypropyl-%C3%AE-cyclodextrin-association-incorporated-in-hydroxypropyl-methylcellulose-hydrogel-exhibits-wound-healing-effect-in-vitro-and-in-vivo-study
#1
Sara E Bianchi, Barbara E K Machado, Marília G C da Silva, Michelle M A da Silva, Lidiane Dal Bosco, Magno S Marques, Ana P Horn, Lara Persich, Fabiana C Geller, Débora Argenta, Helder F Teixeira, Cláudia M O Simões, Cristiana L Dora, Valquíria L Bassani
Several beneficial effects on the skin have been reported for coumestrol (COU), such as protection against photoaging and improvement of skin elasticity and thickness in postmenopausal women. However no reports on the effect of COU on wound healing were found. Nevertheless, COU has low aqueous solubility, which is a crucial limitation for biological tests. The present study was designed as a two-step experiment to evaluate the wound healing effect of COU. First, we used fibroblasts and the experimental in vitro artificial wound model, scratch assay, to compare the effects of COU free, dissolved in dimethyl sulfoxide (DMSO) or Dulbecco's modified Eagle's medium (DMEM), or associated with hydroxypropyl-β-cyclodextrin (HPβCD)...
April 14, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29664771/effects-of-1-540-nm-fractional-nonablative-erbium-and-2-940-nm-fractional-ablative-erbium-on-p53-epidermal-expression-after-3-months-a-split-face-interventional-study
#2
Juliano Borges, Luciana Araújo, Rodrigo P B de Oliveira, Monica Manela-Azulay
BACKGROUND: Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light. OBJECTIVE: We used side-by-side nonablative and ablative erbium fractional laser resurfacing to assess the effects on expression of p53 by facial keratinocytes. METHODS: Ten female patients (age range, 50-63 years) with Fitzpatrick skin Types I-IV and clinical signs of photoaging underwent erbium fractional laser resurfacing (nonablative, 1,540-nm; ablative, 2,940-nm) on opposite sides of the face...
April 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29663701/efficacy-and-safety-of-retinaldehyde-0-1-and-0-05-creams-used-to-treat-photoaged-skin-a-randomized-double-blind-controlled-trial
#3
Hyuck Sun Kwon, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae
BACKGROUND: Although topical retinoic acid effectively restores photoaged skin, the associated irritation limits the utility of the material. Retinaldehyde (RAL) is the natural precursor of retinoic acid and can also be used to treat photoaged skin; the safety profile is good. AIMS: To evaluate the efficacy and safety of new anti-aging creams containing RAL at 0.1% and 0.05% used to treat photoaged skin. PATIENTS AND METHODS: We enrolled 40 female Korean volunteers who applied RAL 0...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29658877/simulation-of-the-elastin-and-fibrillin-in-non-irradiated-or-uva-radiated-fibroblasts-and-direct-inhibition-of-elastase-or-matrix-metalloptoteinases-activity-by-nicotinamide-or-its-derivatives
#4
Neena Philips, Jovinna Chalensouk-Khaosaat, Salvador Gonzalez
Skin aging/photoaging is associated with altered the structure of collagen and elastin fibers, and increased activity of matrix metalloproteinases (MMP) and elastase. Nicotinamide and its derivatives, 2,6-dihydroxynicotinamide, 2,4,5,6-tetrahydroxynicotinamide, and 3-hydroxypicolinamide (collectively niacin derivatives) stimulate fibrillar collagen and heat shock proteins in dermal fibroblasts. The goal of this research was to extend the understanding of the anti-skin aging mechanism of these niacin derivatives through the stimulation of elastin (at the protein and promoter levels), fibrillin (1 and 2) in nonirradiated or ultraviolet (UVA) radiated dermal fibroblasts, and through the direct inhibition of MMP (1, 3, and 9) and elastase activities...
January 2018: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29619069/-piper-retrofractum-vahl-extract-as-a-ppar-%C3%AE-and-ampk-activator-suppresses-uvb-induced-photoaging-through-mitochondrial-biogenesis-and-mmps-inhibition-in-human-dermal-fibroblasts-and-hairless-mice
#5
Jungon Yun, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Photoaging occurs by UVB-irradiation and involves production of reactive oxygen species (ROS) and overexpression of matrix metalloproteinases (MMPs), leading to extracellular matrix damage. Piper retrofractum Vahl. is used as a traditional medicine for antiflatulence, expectorant, sedative, and anti-irritant; however, its antiphotoaging effect has not yet been studied. The current study investigated the antiphotoaging effect of standardized Piper retrofractum extract (PRE) on UVB-damaged human dermal fibroblasts and hairless mouse skin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29616249/anti-aging-potential-of-tree-nuts-with-a-focus-on-the-phytochemical-composition-molecular-mechanisms-and-thermal-stability-of-major-bioactive-compounds
#6
REVIEW
Marius Emil Rusu, Ana-Maria Gheldiu, Andrei Mocan, Laurian Vlase, Daniela-Saveta Popa
Tree nuts, complete functional foods, contain macro- and micronutrients of high biological value. These bioactive compounds have a synergistic effect in preventing and delaying many age-related pathologies (e.g. cardiovascular diseases, stroke, type 2 diabetes mellitus, certain types of cancer, and several neurodegenerative diseases). Tree nuts are low in carbohydrates, but they abound in healthy fatty acids, in optimal proportion for a good plasma lipid profile, and are a good source of proteins, rich in proteinogenic amino acids...
April 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29609010/artemisia-asiatica-ethanol-extract-exhibits-anti-photoaging-activity
#7
Deok Jeong, Jongsung Lee, Seong-Gu Jeong, Yo Han Hong, Sulgi Yoo, Sang Yun Han, Ji Hye Kim, Sunggyu Kim, Jin Sic Kim, Young Soo Chung, Jong-Hoon Kim, Young-Su Yi, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia asiatica Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies. AIM OF THE STUDY: In this study, traditionally known skin-protective activity of Artemisia asiatica Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells...
March 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29604279/resveratrol-protects-hacat-cells-from-ultraviolet-b-induced-photoaging-via-upregulation-of-hsp27-and-modulation-of-mitochondrial-caspase-dependent-apoptotic-pathway
#8
Fen Zhou, Xin Huang, Yun Pan, Di Cao, Chuan Liu, Yiyi Liu, Aijun Chen
The skin is the outermost protective barrier between the internal and external environment in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of photoaging. Evidence suggests that resveratrol suppresses UVB-induced photoaging. In this study, we aimed to investigate the protective effects of resveratrol against UVB-induced photoaging in HaCaT cells and to determine the underlying mechanisms. Apoptosis of normal or HSP27-overexpressing HaCaT cells in the presence of UVB was analyzed by flow cytometry...
March 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29597313/protective-effects-of-lsgygp-from-fish-skin-gelatin-hydrolysates-on-uvb-induced-mefs-by-regulation-of-oxidative-stress-and-matrix-metalloproteinase-activity
#9
Qingyu Ma, Qiuming Liu, Ling Yuan, Yongliang Zhuang
A previous study has shown that tilapia fish skin gelatin hydrolysates inhibited photoaging in vivo, and that, Leu-Ser-Gly-Tyr-Gly-Pro (LSGYGP) identified in the hydrolysate had a high hydroxyl radical scavenging activity. In this study, activities of LSGYGP were further evaluated using ultraviolet B (UVB)-induced mouse embryonic fibroblasts (MEFs). UVB irradiation significantly increased the intercellular reactive oxygen species (ROS) production and matrix metalloproteinases (MMPs) activities and decreased the content of collagen in MEFs...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29593531/stereoisomers-of-saponins-in-panax-notoginseng-sanqi-a-review
#10
REVIEW
Ming Peng, Ya X Yi, Tong Zhang, Yue Ding, Jian Le
Panax notoginseng (Sanqi), a traditional Chinese medical drug which has been applied to medical use for over four centuries, contains high content of dammarane-type tetracyclic triterpenoid saponins. A number of stereoisomeric dammarane-type saponins exist in this precious herb, and some are particularly regarded as "biomarkers" in processed notoginseng. Contemporary researches have indicated that some saponin stereoisomers may show stereospecific pharmacological activities, such as anti-tumor, antioxidative, anti-photoaging, anti-inflammatory, antidiabetic, and neuro-protective activities, as well as stereoselective effects on ion channel current regulation, cardiovascular system, and immune system...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29580452/effect-of-age-gender-and-sun-exposure-on-ethnic-skin-photoaging-evidence-gathered-using-a-new-photonumeric-scale
#11
Anna L Chien, Ji Qi, Radhika Grandhi, Noori Kim, Sabrina Sisto Alessi César, Tamia Harris-Tryon, Min Soo Jang, Omolara Olowoyeye, Diane Kuhn, Sherry Leung, Barbara M Rainer, Flora Poon, Jean Suh, Nancy Cheng, Ginette A Okoye, Sewon Kang
BACKGROUND: African-Americans are less affected by photoaging than lighter skin individuals. Although scales for photoaging have been developed for Caucasians and Asians, no scale exists for African-Americans. AIM: To develop a photonumeric scale for photoaging and to determine factors that contribute to photoaging in African-Americans. METHODS: Five participants' photographs were selected as standards to create a 9-point photonumeric scale (0 = none, 8 = most severe)...
April 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29576056/brazilin-and-caesalpinia-sappan-l-extract-protect-epidermal-keratinocytes-from-oxidative-stress-by-inducing-the-expression-of-gpx7
#12
Hyung Seo Hwang, Joong Hyun Shim
Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treatment of diarrhea, dysentery, tuberculosis, skin infections, and inflammation. Brazilin is the major active compound, which has exhibited various pharmacological effects, including anti-platelet activity, anti-hepatotoxicity, induction of immunological tolerance, and anti-inflammatory and antioxidant activities...
March 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29568864/protective-effect-of-curcumin-against-ultraviolet-a-irradiation%C3%A2-induced-photoaging-in-human-dermal-fibroblasts
#13
Xiaoming Liu, Ruizhi Zhang, Haixia Shi, Xiaobo Li, Yanhong Li, Ahmad Taha, Chunxing Xu
Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in skin, resulting in photoaging. Natural botanicals have gained considerable attention due to their beneficial protection against the harmful effects of UV irradiation. The present study aimed to evaluate the ability of curcumin (Cur) to protect human dermal fibroblasts (HDFs) against ultraviolet A (UVA)‑induced photoaging. HDFs were treated with 0‑10 µM Cur for 2 h and subsequently exposed to various intensities of UVA irradiation...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29545866/gsk126-ezh2-inhibitor-interferes-with-ultraviolet-a-radiation-induced-photoaging-of-human-skin-fibroblast-cells
#14
Haiyan Qin, Guang Zhang, Lianbo Zhang
Polycomb group genes (PcG) encode chromatin modification proteins that are involved in the epigenetic regulation of cell differentiation, proliferation and the aging processes. The key subunit of the PcG complex, enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), has a central role in a variety of mechanisms, such as the formation of chromatin structure, gene expression regulation and DNA damage. In the present study, ultraviolet A (UVA) was used to radiate human dermal fibroblasts in order to construct a photo-aged cell model...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29545203/photoaging-and-skin-cancer-is-the-inflammasome-the-missing-link
#15
REVIEW
Fawaz Awad, Eman Assrawi, Camille Louvrier, Claire Jumeau, Irina Giurgea, Serge Amselem, Sonia-Athina Karabina
Photoaging and epithelial skin tumorigenesis are complex processes triggered mainly by UV radiation from chronic sun exposure. This leads to DNA damage and reactive oxygen species (ROS) production, which initiate an inflammatory response that alters cell structure and function. Changes in cell homeostasis and ROS production activate intracellular multiprotein platforms called inflammasomes. Inflammasomes nucleate around cytoplasmic receptors mainly of the NLR (nucleotide-binding domain and leucine-rich repeat) family and regulate caspase-1-dependant secretion of pro-inflammatory interleukin (IL)-1β and IL-18 cytokines, and an inflammatory form of death named pyroptosis...
March 12, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29536579/relationship-of-hyaluronan-and-hybid-kiaa1199-expression-with-roughness-parameters-of-photoaged-skin-in-caucasian-women
#16
H Yoshida, A Komiya, R Ohtsuki, A Kusaka-Kikushima, S Sakai, K Kawabata, M Kobayashi, S Nakamura, A Nagaoka, T Sayo, Y Okada, Y Takahashi
BACKGROUND: Hyaluronan (HA) is an important constituent of extracellular matrix (ECM) in the skin, and HA degradation mediated by HYBID (KIAA1199) is suggested to be implicated in facial skin wrinkling in Japanese women. Ethnic difference in skin wrinkle formation is known between Caucasian and Japanese women, but no information is available for the relations of HA and HYBID expression levels with skin wrinkling in Caucasian women. METHODS: The skin surface roughness at the eye corner of the Caucasian female subjects was measured, and the skin specimens biopsied from the same areas were subjected to microarray gene analysis, HA staining, and immunohistochemistry for HYBID...
March 14, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29532749/nanotechnological-advances-for-cutaneous-release-of-tretinoin-an-approach-to-minimize-side-effects-and-improve-therapeutic-efficacy
#17
Ana Claudia Pompeu Raminelli, Valeria Romero, Mohammad H Semreen, Gislaine Ricci Leonardi
The clinical efficacy of the topical tretinoin is widely studied and has been well established for many therapeutic interventions, among some, photoaging, acne, and melasma. However, the side effects, mainly cutaneous irritation, erythema, xerosis and peeling, remain major obstacle to the patient compliance. Besides, the insight regarding the drug delivery profile is essential to understand the therapeutic action of the drug. Herein we highlight further advances and an update on tretinoin delivery systems such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrins, nanostructured polymers and other technological systems that reduce its side effects and improve the permeation profile to potentiate efficacy and drug safety on the skin...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29532689/protective-effect-of-neferine-against-uv-b-mediated-oxidative-damage-in-human-epidermal-keratinocytes
#18
Abidullah Khan, Bai Hongliang, Enqi Liu, Chen Mingxia, Yu Chunshui, Rai Wang, Khan Amin, Bai Zhuanli
Studies have shown that skin exposure to ultraviolet radiation (UVR) results in the formation of reactive oxygen species (ROS), thus altering the cellular function. The human epidermal skin layer is mainly composed of keratinocytes, which is damaged by UV-B radiation induced intracellular oxidative stress. Neferine is an alkaloid extract from lotus seed embryos, and its photoprotective action against UV-B produced oxidative damage in human epidermal keratinocytes (HEKs) has never been proposed. Neferine inhibited UV-B mediated increase in ROS and malondialdehyde (MDA) levels in pretreated keratinocytes...
March 13, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29525471/exposure-of-human-melanocytes-to-uvb-twice-and-subsequent-incubation-leads-to-cellular-senescence-and-senescence-associated-pigmentation-through-the-prolonged-p53-expression
#19
Suh-Yeon Choi, Bum-Ho Bin, Wanil Kim, Eunkyung Lee, Tae Ryong Lee, Eun-Gyung Cho
BACKGROUND: Ultraviolet radiation (UVR) is a well-known factor in skin aging and pigmentation, and daily exposure to subcytotoxic doses of UVR might accelerate senescence and senescence-associated phenomena in human melanocytes. OBJECTIVE: To establish an in vitro melanocyte model to mimic the conditions of repeated exposure to subcytotoxic doses of UVB irradiation and to investigate key factor(s) for melanocyte senescence and senescence-associated phenomena. METHODS: Human epidermal melanocytes were exposed twice with 20 mJ/cm2 UVB over a 24-h interval and subsequently cultivated for 2 weeks...
March 2, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29523502/a-skin-cancer-prevention-facial-aging-mobile-app-for-secondary-schools-in-brazil-appearance-focused-interventional-study
#20
Titus Josef Brinker, Marlene Heckl, Martina Gatzka, Markus V Heppt, Henrique Resende Rodrigues, Sven Schneider, Wiebke Sondermann, Carolina de Almeida E Silva, Michael C Kirchberger, Joachim Klode, Alexander H Enk, Sarah Knispel, Christof von Kalle, Ingo Stoffels, Dirk Schadendorf, Yasuhiro Nakamura, Stefan Esser, Aisllan Assis, Breno Bernardes-Souza
BACKGROUND: The incidence of melanoma is increasing faster than any other major cancer both in Brazil and worldwide. Southeast Brazil has especially high incidences of melanoma, and early detection is low. Exposure to ultraviolet (UV) radiation is a primary risk factor for developing melanoma. Increasing attractiveness is a major motivation among adolescents for tanning. A medical student-delivered intervention that takes advantage of the broad availability of mobile phones and adolescents' interest in their appearance indicated effectiveness in a recent study from Germany...
March 9, 2018: JMIR MHealth and UHealth
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