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Salivary diagnostics

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https://www.readbyqxmd.com/read/29790307/necrotising-sialometaplasia-a-diagnostic-perplexity-an-innocent-entity-to-malignant-masquerade
#1
Neeti Swarup, Meghanand T Nayak, Zoya Chowdhary, S Chandarani
Necrotising Sialometaplasia is a benign self limiting reactive condition of major and minor salivary glands, which can arouse suspicion for malignancy, clinically and histopathologically. Here, we report a case of 38-year-old female with a painful ulcer on the palate. The case enlightens the importance of clinicopathologic correlation and diligent follow up in diagnosis and management of the case.
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29787840/cutaneous-features-and-diagnosis-of-primary-sjogren-s-syndrome-an-update-and-review
#2
REVIEW
Preeti Jhorar, Kristin Torre, Jun Lu
Sjogren's syndrome (SS) is an autoimmune connective tissue disorder (CTD) which principally affects the lacrimal and salivary glands. Although SS is one of the three most common autoimmune CTDs alongside systemic lupus erythematosus (SLE) and progressive systemic sclerosis, it is the least researched CTD overall. SS poses a particular diagnostic challenge because it shares multiple clinical and immunologic features with other CTDs. However, there are some characteristic cutaneous clinical features that can precede the well-known sicca symptoms by years...
May 19, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29785551/salivary-duct-carcinoma-evaluation-of-treatment-and-outcome-in-a-tertiary-referral-institute
#3
Ann-Jean C C Beck, Peter J F M Lohuis, Abrahim Al-Mamgani, Laura A Smit, Willem M C Klop
PURPOSE: The aggressive behavior of salivary duct carcinoma (SDC) necessitates an aggressive treatment strategy, including surgery and radiotherapy (RT). We evaluated practice patterns and treatment outcomes in patients with SDC treated in our Institute. METHODS: Patients with SDC of the parotid or submandibular gland treated with curative intention in our Institute from 1998 until 2016 were reviewed. Our diagnostic workup and treatment strategy were evaluated together with treatment outcomes...
May 21, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29763839/salivary-fingerprint-of-simple-obesity
#4
Anna Lehmann-Kalata, Izabela Miechowicz, Katarzyna Korybalska, Ewelina Swora-Cwynar, Natasza Czepulis, Joanna Łuczak, Zofia Orzechowska, Marian Grzymisławski, Anna Surdacka, Janusz Witowski
BACKGROUND: The nature of a link between poor oral health and obesity is not fully understood. It is also unclear if saliva contributes to it and whether the properties of saliva change as a result of an increase in body mass or rather as a consequence of obesity-associated comorbidities. This pilot study was undertaken in an attempt to determine if salivary biomarkers can identify obesity per se. METHODS: Whole mixed saliva was analysed for 16 soluble parameters covering 4 categories (inflammation, oxidative stress, endothelial dysfunction, adipokines)...
May 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29762691/diagnostic-accuracy-of-post-acth-challenge-salivary-cortisol-concentrations-for-identifying-horses-with-equine-glandular-gastric-disease
#5
Fay J Sauer, Rupert M Bruckmaier, Alessandra Ramseyer, Beatriz Vidondo, Milena D Scheidegger, Vinzenz Gerber
The aims of this study were to better characterize the adrenal response to i.v. adrenocorticotropic hormone (ACTH) in horses with and without gastric disease and to validate and simplify the ACTH stimulation test by determining the diagnostic accuracy of six consecutive sampling time points after ACTH administration for equine glandular gastric disease (EGGD) and equine squamous gastric disease (ESGD). Twenty-six endurance and eventing horses without clinical disease [Sport Horse Population (SHP)] and an independent population of 62 horses [General Population (GP)] were grouped by gastroscopic findings (no/mild vs...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29761209/polymorphous-adenocarcinoma-of-the-salivary-glands-reappraisal-and-update
#6
REVIEW
Vincent Vander Poorten, Asterios Triantafyllou, Alena Skálová, Göran Stenman, Justin A Bishop, Esther Hauben, Jennifer L Hunt, Henrik Hellquist, Simon Feys, Remco De Bree, Antti A Mäkitie, Miquel Quer, Primož Strojan, Orlando Guntinas-Lichius, Alessandra Rinaldo, Alfio Ferlito
Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG)...
May 14, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29760580/sinonasal-adenoid-cystic-carcinoma-role-of-on-site-fnac-a-case-report
#7
Santosh Tummidi, Kanchan Kothari, Roshni Patil, Shruti S Singhal, Vyoma Shah
Background: Adenoid cystic carcinoma (ACC), a rare tumor of epithelial cell origin, commonly arises from the major salivary glands. Uncommonly it may be found outside the salivary glands and it's especially rare in the nasal cavity. Case presentation: A 71-year female had complaints of swelling at the base of nose, Fine needle aspiration (FNA) from the swelling revealed features of adenoid cystic carcinoma; cell block & IHC for CD-117 was positive. Conclusions: Sino-nasal ACC (SNACC) continues to pose diagnostic and therapeutic challenges to clinicians...
2018: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29755368/saliva-proteomics-analysis-offers-insights-on-type-1-diabetes-pathology-in-a-pediatric-population
#8
Eftychia Pappa, Heleni Vastardis, George Mermelekas, Andriani Gerasimidi-Vazeou, Jerome Zoidakis, Konstantinos Vougas
The composition of the salivary proteome is affected by pathological conditions. We analyzed by high resolution mass spectrometry approaches saliva samples collected from children and adolescents with type 1 diabetes and healthy controls. The list of more than 2000 high confidence protein identifications constitutes a comprehensive characterization of the salivary proteome. Patients with good glycemic regulation and healthy individuals have comparable proteomic profiles. In contrast, a significant number of differentially expressed proteins were identified in the saliva of patients with poor glycemic regulation compared to patients with good glycemic control and healthy children...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29754884/circulating-salivary-mirna-hsa-mir-221-as-clinically-validated-diagnostic-marker-for-hand-foot-and-mouth-disease-in-pediatric-patients
#9
Nyo Min, Previtha Dawn Sakthi Vale, Anng Anng Wong, Natalie Woon Hui Tan, Chia Yin Chong, Chih-Jung Chen, Robert Y L Wang, Justin Jang Hann Chu
Enhancements in the diagnostic capabilities using host biomarkers are currently much needed where sensitivity and specificity issues plague the diagnosis of Hand, Foot and Mouth Disease (HFMD) in pediatrics clinical samples. We investigated miRNome profiles of HFMD saliva samples against healthy children and developed miRNA-based diagnosis models. Our 6-miRNA scoring model predicted HFMD with an overall accuracy of 85.11% in the training set and 92.86% in the blinded test set of Singapore cohort. Blinded evaluation of the model in Taiwan HFMD cases resulted in 77...
May 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29751148/salivary-immunoglobulin-levels-in-juvenile-autoimmune-hepatitis
#10
Juliana Ximenes Damasceno, Maria Izabel Florindo Guedes, Christiane Araujo Chaves Leite, André Jalles Monteiro, Manasses Claudino Fonteles, Maria Esther Zurita Jimenez, Vilma de Lima, Thyciana Rodrigues Ribeiro, Cristiane Sá Roriz Fonteles
AIMS: The aim of the present study was to investigate the presence of immunoglobulins (Ig) in whole saliva from patients affected by autoimmune hepatitis (AIH). DESIGN: Twelve individuals with AIH and 12 healthy individuals without (CON) autoimmune hepatitis, aged 8-18 years, participated in this study. Non-stimulated whole saliva was collected and centrifuged. Supernatants were separated and lyophilized. Salivary pH was measured and immunoglobulins were analyzed through ELISA technique...
May 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29750386/saliva-in-the-omics-era-a-promising-tool-in-paediatrics
#11
Eftychia Pappa, Eleni Kousvelari, Heleni Vastardis
In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its non-invasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29749993/central-acinic-cell-carcinoma-of-the-mandible-simulating-as-benign-odontogenic-lesion-a-case-report
#12
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29744207/salivary-intercellular-adenosine-triphosphate-testing-in-primary-caretakers-an-examination-of-statistical-significance-versus-diagnostic-predictability
#13
Crystal Bill, Judy A Danielson, Robert S Jones
A primary caretaker is a potential reservoir of bacteria for an infant child and can be evaluated during a child's caries risk assessment. The aim of this study was to investigate an indirect method for assessing Streptococcus mutans and Streptococcus sobrinus (MS) and lactobacillus (LB) levels in a caretaker's saliva. Thirty-eight primary caretakers participated in the study to determine whether a 2-step method to assess the intracellular adenosine triphosphate (ATP) levels in saliva (saliva i-ATP method) predicted higher MS and LB levels...
December 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29740515/il-6-and-tnf-%C3%AE-salivary-levels-according-to-the-periodontal-status-in-portuguese-pregnant-women
#14
Vanessa Machado, Maria Fernanda Mesquita, Maria Alexandra Bernardo, Ester Casal, Luís Proença, José João Mendes
Background: Periodontitis is associated with increased concentration of inflammatory markers and saliva has been proposed as a non-invasive diagnostic fluid in oral and systemic diseases. The levels of salivary biomarkers, such as cytokines, could potentially be used to distinguish periodontal healthy individuals from subjects with periodontal disease. The purpose of this study was to characterize the salivary levels of two inflammatory biomarkers associated with periodontitis, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), in order to assess whether these cytokines salivary levels could potentially be used to complement periodontitis pregnant women diagnose...
2018: PeerJ
https://www.readbyqxmd.com/read/29738361/intraductal-papillary-mucinous-neoplasms-of-minor-salivary-glands-with-akt1-p-glu17lys-mutation
#15
Abbas Agaimy, Sarina K Mueller, Klaus Bumm, Heinrich Iro, Evgeny A Moskalev, Arndt Hartmann, Robert Stoehr, Florian Haller
The spectrum of low-grade intraductal papillary proliferations of the salivary glands is heterogenous, and reproducible morphologic diagnostic criteria have not yet been established. Recognized types are sialadenoma papilliferum, inverted ductal papilloma, and intraductal papilloma, but some lesions have been possibly included in the morphologic spectrum of cystadenoma or low-grade intraductal carcinomas. We herein present detailed morphologic, immunophenotypic, and genotypic features of 3 minor salivary gland neoplasms affecting 2 men (aged 65 and 71 y) and 1 woman (aged 78 y)...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29731570/clear-cell-carcinoma-of-palatine-salivary-gland-a-diagnostic-challenge
#16
Karpagaselvi Sanjai, Divya Shivalingaiah, Ranjini Sharath, Bhavna Pandey
No abstract text is available yet for this article.
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29728539/immunohistochemical-detection-of-proliferative-marker-ki-67-in-benign-and-malignant-salivary-gland-tumors
#17
Smita Bussari, Sindhu M Ganvir, Manish Sarode, Prabhakar A Jeergal, Anjum Deshmukh, Himanshu Srivastava
Introduction: Salivary gland tumors are the most histologically heterogeneous group of tumors with the greatest diversity of morphologic features among their cells and tissues. The present study was aimed at assessing the validity of Ki-67, a cell proliferation marker, as a prognostic factor in benign and malignant salivary gland tumors and to study whether it is related to age, sex, anatomical site, and size of the lesion in salivary gland tumors. Materials and methods: A retrospective study consisted of benign salivary gland tumors (BSGTs) (n = 15), malignant salivary gland tumors (n = 18), and normal salivary gland parenchyma (n = 15)...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29723435/impact-on-clinical-follow-up-of-the-milan-system-for-salivary-gland-cytology-a-comparison-with-a-traditional-diagnostic-classification
#18
Lester J Layfield, Zubair Baloch, Sharon L Hirschowitz, Esther D Rossi
OBJECTIVE: No universally accepted classification exists for salivary gland fine-needle aspiration (FNA). The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) offers a uniform classification with management recommendations. We compared FNA diagnoses from a prior study with specific diagnoses with corresponding MSRSGC diagnoses. METHODS: One-hundred and sixty-four cases from a prior cytologic study with histologic follow-up were re-reviewed by one of the authors and assigned to one of the MSRSGC categories...
May 3, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29721505/salivary-biomarkers-in-systemic-sclerosis-disease
#19
REVIEW
Zeineb Zian, Joaira Bakkach, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita
Scleroderma or systemic sclerosis (SSc) is frequently detected at an advanced stage due to diagnosis difficulties. Salivary biomarkers, if existing, could be used for predictive diagnosis of this disease. Human saliva contains a large number of proteins that can be used for diagnosis and are of great potential in clinical research. The use of proteomic analysis to characterize whole saliva (WS) in SSc has gained an increasing attention in the last years and the identification of salivary proteins specific for SSc could lead to early diagnosis or new therapeutic targets...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29720332/standard-and-low-dose-cone-beam-computer-tomography-protocol-for-orthognatodontic-diagnosis-a-comparative-evaluation
#20
M Portelli, A Militi, A Lo Giudice, R Lo Giudice, R Fastuca, I Ielo, V Mongelli, G Lo Giudice, A Martintoni, M Manuelli, A Lucchese, R Nucera
Considering the diagnostic capability offered by cone-beam computed tomography (CBCT), nowadays orthodontists often use this exam for treatment planning, especially in cases of impacted teeth, maxillary ipoplasia, orthognathic surgery etc. The aim of this study was to compare the radiation doses related to a conventional CBCT setting and that of a low dose protocol, usable in orthodontic practice. The absorbed organ doses were measured using an anthropomorphic phantom loaded with thermo-luminescent dosimeters related to sensitive organs (brain, bone marrow, salivary glands, thyroid, esophagus, oral mucosa, extrathoracic airways, lymph nodes)...
March 2018: Journal of Biological Regulators and Homeostatic Agents
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