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Salivary diagnostics

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https://www.readbyqxmd.com/read/28210575/cytokeratin-immunoprofile-of-primary-and-metastatic-adenoid-cystic-carcinoma-of-salivary-glands-a-report-of-two-cases
#1
Cibele Pidorodeski Nagano, Cláudia Malheiros Coutinho-Camillo, Clovis Antônio Pinto, Fernando Augusto Soares, Filipa Santos, Isabel Fonseca, Silvia Vanessa Lourenço
Distant metastases from salivary gland tumors are considered infrequent: the incidence of distant metastases ranges from 24% to 61% according to different histotypes and to the site of the primary mass. The most common site of distant metastases due to salivary gland malignancies is the lung. From the pathology point of view, cytokeratins (CK) are important differentiation markers in salivary gland tumors, which are often used for the diagnostic process. Their employment also may be useful to identify and confirm the diagnosis of their distant metastases...
October 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/28186864/within-day-baseline-variation-in-salivary-biomarkers-in-healthy-men
#2
Firman Prathama Idris, Yunxia Wan, Xi Zhang, Chamindie Punyadeera
Saliva is an easily accessible sample and offers practical and noninvasive biomarker solutions as an alternative to blood and urine-based diagnostics. Saliva contains a plethora of biomolecules such as nucleic acids, hormones, proteins, and electrolytes. On the other hand, little is known on the extent to which the biomolecules in saliva vary over time within a given person. This baseline information is crucial for future development of robust saliva-based diagnostics. We have collected unstimulated whole mouth saliva from 20 healthy young men at four times during the day, including before and after a meal...
February 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28180194/prospective-evaluation-of-quasistatic-ultrasound-elastography-use-compared-with-baseline-us-for-parotid-gland-lesions-preliminary-results-of-elasticity-contrast-index-eci-evaluation
#3
Vito Cantisani, Emanuele David, Armando De Virgilio, Paul S Sidhu, Hektor Grazhdani, Antonio Greco, Marco De Vincentiis, Alessandro Corsi, Flaminia De Cristofaro, Luca Brunese, Fabrizio Calliada, Alfredo Blandino, Mario Tombolini, Giorgio Ascenti, Roberto Stramare, Marcello Caratozzolo, Ferdinando D'Ambrosio
AIMS: To assess the diagnostic value of elasticity contrast index (ECI) elastography, in comparison with conventional ultrasound for the differentiation of benign and malignant parotid lesions. MATERIAL AND METHODS: Sixty-three consecutive patients with parotid gland tumors, treated surgically at a single tertiary center were enrolled. Ultrasound evaluation consisted of B-mode, color-Doppler and quasistatic ultrasound elastography (USE), conducted with the ECI technique...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28179447/diagnosis-of-endocrine-disease-differentiation-of-pathologic-neoplastic-hypercortisolism-cushing-syndrome-from-physiologic-non-neoplastic-hypercortisolism-formerly-known-as-pseudo-cushing-syndrome
#4
James Findling, Hershel Raff
Endogenous hypercortisolism (Cushing syndrome) usually implies the presence of a pathologic condition caused by either an ACTH-secreting neoplasm or autonomous cortisol secretion from a benign or malignant adrenal neoplasm. However, sustained or intermittent hypercortisolism may also accompany many medical disorders that stimulate physiologic/non-neoplastic activation of the HPA axis (formerly known as pseudo-Cushing syndrome); these two entities may share indistinguishable clinical and biochemical features...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28178123/spectrum-of-pediatric-tumors-diagnosed-by-fine-needle-aspiration-cytology
#5
Sadegh Shirian, Yahya Daneshbod, Sezaneh Haghpanah, Bijan Khademi, Farshid Noorbakhsh, Amir Ghaemi, Ziba Mosayebi
Pediatric tumors differ markedly from adult tumors in their nature, distribution, and prognosis. In this 10-year retrospective study, we present our experience with fine-needle aspiration (FNA) in pediatric patients 18 years of age and younger and correlate relationship between gender with organ, diagnosis, malignancy, and age. In our study, FNA material of pediatric tumors or masses with 18 years aged and younger were analyzed retrospectively.All FNAs in pediatric patients during this time period were identified and analyzed for age, gender, cytologic diagnosis, and site of aspiration...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177330/outcomes-of-interventional-sialendoscopy-for-obstructive-salivary-gland-disorders-an-italian-multicentre-study
#6
A Gallo, P Capaccio, M Benazzo, L De Campora, M De Vincentiis, P Farneti, M Fusconi, M Gaffuri, F Lo Russo, S Martellucci, F Ottaviani, G Pagliuca, G Paludetti, E Pasquini, L Pignataro, R Puxeddu, M Rigante, E Scarano, S Sionis, R Speciale, P Canzi
Interventional sialendoscopy has become the predominant therapeutic procedure for the management of obstructive salivary disorders, but only a few multicentre studies of large series of patients with a long-term follow-up have been published. This Italian multicentre study involved 1152 patients (553 females; mean age 50 years) who, after at least a clinical and ultrasonographic evaluation, underwent a total of 1342 diagnostic and interventional sialendoscopies, 44.6% of which involved the parotid gland. 12% (n = 138) of patients underwent multiple treatments...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28177057/salivary-cortisol-and-%C3%AE-amylase-subclinical-indicators-of-stress-as-cardiometabolic-risk
#7
S Cozma, L C Dima-Cozma, C M Ghiciuc, V Pasquali, A Saponaro, F R Patacchioli
Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and α-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and α-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators...
February 6, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28160595/salivary-mmp-9-in-the-detection-of-oral-squamous-cell-carcinoma
#8
A Peisker, G-F Raschke, M-D Fahmy, A Guentsch, K Roshanghias, J Hennings, S Schultze-Mosgau
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most common malignant tumour of the oral cavity. Detection of OSCC is currently based on clinical oral examination combined with histopathological evaluation of a biopsy sample. Direct contact between saliva and the oral cancer makes measurement of salivary metalloproteinase-9 (MMP-9) an attractive alternative. MATERIAL AND METHODS: In total, 30 OSCC patients and 30 healthy controls were included in this prospective study...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28130626/simulated-airplane-headache-a-proxy-towards-identification-of-underlying-mechanisms
#9
Sebastian Bao Dinh Bui, Torben Petersen, Jeppe Nørgaard Poulsen, Parisa Gazerani
BACKGROUND: Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrence of this headache. Proper diagnosis and treatments would benefit from identification of potential pathways involved in AH pathogenesis. This study aimed at providing a simulated airplane headache condition as a proxy towards identification of its underlying mechanisms. METHODS: Fourteen participants including 7 volunteers suffering from AH and 7 healthy matched controls were recruited after meeting the diagnostic and safety criteria based on an approved study protocol...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28122643/identification-of-potential-saliva-and-tear-biomarkers-in-primary-sj%C3%A3-gren-s-syndrome-utilising-the-extraction-of-extracellular-vesicles-and-proteomics-analysis
#10
Lara A Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Janicke Liaaen Jensen
BACKGROUND: There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren's syndrome (pSS) patients. Incorporation of additional diagnostics involving screening for disease-specific biomarkers in biological fluid is a promising concept that requires further investigation. In the current study we aimed to explore novel disease biomarkers in saliva and tears from pSS patients. METHODS: Liquid chromatography-mass spectrometry (LC-MS) was performed on stimulated whole saliva and tears from 27 pSS patients and 32 healthy controls, and salivary and tear proteomic biomarker profiles were generated...
January 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28117682/salivary-diagnostics-point-of-care-diagnostics-of-mmp-8-in-dentistry-and-medicine
#11
REVIEW
Nilminie Rathnayake, Dirk-Rolf Gieselmann, Anna Maria Heikkinen, Taina Tervahartiala, Timo Sorsa
Human saliva is an easily accessible biological fluid and contains a variety of disease-related biomarkers, which makes it a potential diagnostic medium. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires the development of non-invasive screening and diagnostic technologies, and is among the main goals of oral fluid researchers. The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth-rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) is demanding...
January 20, 2017: Diagnostics
https://www.readbyqxmd.com/read/28109406/salivary-biomarkers-in-the-diagnosis-of-breast-cancer-a-review
#12
REVIEW
Elisa Cançado Porto-Mascarenhas, Daniele Xavier Assad, Hélène Chardin, David Gozal, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra
Salivary biomarkers could be helpful to characterize breast cancer. Therefore, this review was performed to evaluate the capability of salivary biological markers in the diagnosis and monitoring of breast cancer. Studies were eligible for inclusion if they assessed the potential diagnostic value or other discriminatory properties of biological markers in saliva of patients with breast cancer. The search was performed in six electronic databases (Cochrane, LILACS, PubMed, Science Direct, Scopus, Web of Science)...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28108853/brain-metastasis-of-carcinoma-ex-pleomorphic-adenoma-of-the-parotid-gland-case-report-and-review-of-the-literature
#13
Ruth Lau, Alejandro Fernández-Coello, Noemí Vidal-Sarró, Dennis Céspedes, Angels Camins, Miren Taberna, Andreu Gabarrós
We present an extremely infrequent case of brain metastasis of a parotid tumor. To our knowledge, this is the second case reported of a brain metastasis of a malignant parotid tumor, carcinoma ex pleomorphic adenoma. Pleomorphic adenoma represents 60% of tumors of the parotid gland, and although it is a benign tumor, it can transform into carcinoma ex pleomorphic adenoma in 5% of cases, one of the most aggressive neoplasms of the salivary glands. We want to note the need for an accurate diagnostic. Thanks to aggressive surgical management, our patient survived more than 1½ years...
March 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28105726/biological-stress-indicators-as-risk-markers-for-increased-alcohol-use-following-traumatic-experiences
#14
Sebastian Trautmann, Markus Muehlhan, Clemens Kirschbaum, Hans-Ulrich Wittchen, Michael Höfler, Tobias Stalder, Susann Steudte-Schmiedgen
Alcohol misuse is a common sequela of traumatic event experiences causing considerable morbidity and mortality. Although biological stress indicators have been identified as useful risk markers for the development of trauma-related disorders, no such biological indicators exist for the risk of increased alcohol use after trauma exposure. This is the first study to prospectively investigate the predictive value of long-term cortisol levels and acute stress reactivity for the risk of increased alcohol use following traumatic events...
January 20, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28100191/diagnostic-dilemma-of-pulmonary-tuberculosis-among-adults-with-severe-mental-illness-in-beijing-china
#15
Li Wang, Zhiguo Zhang, Qiuli Yan, Jie Lu, Baoyin Gao, Yanlin Zhao, Yu Pang
BACKGROUND: Although the prevalence of tuberculosis has decreased significantly over the past decades, the certain populations with mental illness are at increased risk for tuberculosis infection and transmission. However, no studies have examined the performance of different laboratory examination methods among people with severe mental illness in China. METHODS: In this study, we firstly performed a retrospective study to evaluate the feasibility of three routine laboratory methods, including sputum microscopy, solid culture and GeneXpert, to diagnose tuberculosis patients with mental illness...
January 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28095062/microrna-196a-as-a-potential-diagnostic-biomarker-for-esophageal-squamous-cell-carcinoma
#16
Mona Fendereski, Mohammad Farid Zia, Mohammad Shafiee, Forousan Safari, Mohammad Hosien Saneie, Manoochehr Tavassoli
We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p = .002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC...
January 17, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28076460/the-accuracy-of-fine-needle-aspiration-cytology-for-diagnosis-of-parotid-gland-masses-a-clinicopathological-study-of-114-patients
#17
Jens Kristjan Gudmundsson, Aida Ajan, Jahan Abtahi
Objective: Fine-needle aspiration cytology is a valuable method for preoperative assessment of head and neck tumors. However, its accuracy in detection of salivary gland masses is controversial compared with other methods. The aim of this work was to evaluate the effectiveness and accuracy of fine-needle aspiration cytology (FNAC) in the diagnosis of parotid gland masses. Material and Methods: Over a 10-year period, 126 parotid gland masses were resected. Retrospective chart reviews of 114 patients were performed...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28072974/-clinicopathologic-features-of-mammary-analogue-secretory-carcinoma-of-salivary-glands
#18
X P Zhang, H Ni, X Wang, H Chen, S S Shi, B Yu, X J Zhou, Q Rao
Objective: To investigate the clinicopathological features of mammary analogue secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential diagnosis, immunohistochemistry and molecular pathology. Methods: Seventeen cases of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital from 1997 to 2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28072618/18f-fdg-pet-ct-versus-contrast-enhanced-ct-for-staging-and-prognostic-prediction-in-patients-with-salivary-gland-carcinomas
#19
Marn Joon Park, Jungsu S Oh, Jong-Lyel Roh, Jae Seung Kim, Jeong Hyun Lee, Soon Yuhl Nam, Sang Yoon Kim
PURPOSE: Salivary gland carcinoma (SGC) is rare tumor with various histological type and metastatic potential. Pretreatment detection of metastases can contribute to planning the appropriate treatment of SGC. Therefore, the present study evaluated the utility of F-FDG PET/CT versus contrast-enhanced CT for detection of metastases and prediction of outcomes in SGC patients. METHODS: Sixty-seven consecutive SGC patients who were prospectively evaluated by F-FDG PET/CT and contrast-enhanced CT and subsequently underwent surgery with or without postoperative radiotherapy/chemoradiotherapy were included...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28069628/cushing-s-syndrome-a-practical-approach-to-diagnosis-and-differential-diagnoses
#20
Joseph M Pappachan, Christian Hariman, Mahamood Edavalath, Julian Waldron, Fahmy W Hanna
Diagnosis of Cushing's syndrome (CS) and identification of the aetiology of hypercortisolism can be challenging. The Endocrine Society clinical practice guidelines recommends one of the four tests for initial screening of CS, namely, urinary-free cortisol, late night salivary cortisol, overnight dexamethasone suppression test or a longer low-dose dexamethasone suppression test, for 48 hours. Confirmation and localisation of CS requires additional biochemical and radiological tests. Radiological evaluation involves different imaging modalities including MRI with or without different radio-nuclear imaging techniques...
January 9, 2017: Journal of Clinical Pathology
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