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Penicillin susceptible staphylococcus

Albert Boada, Mariona Pons-Vigués, Jordi Real, Elisabet Grezner, Bonventura Bolíbar, Carl Llor
INTRODUCTION: Commensal flora of healthy people is becoming an important reservoir of resistant bacteria. OBJECTIVES: To evaluate the relationship of previous antibiotic-dispensed and resistance pattern of strains of Staphylococcus aureus in primary care patients. METHODS: A cross-sectional study was carried out in seven primary care centres in Catalonia, Spain, from October 2010 to May 2011, as part of the APRES (The appropriateness of prescribing antibiotics in primary care in Europe concerning antibiotic resistance) study...
December 2018: European Journal of General Practice
Marguerite L Monogue, Jessica K Ortwine, Wenjing Wei, Khalid Eljaaly, Kavita P Bhavan
BACKGROUND: Anti-staphylococcal penicillins have long been the first-line treatment option for methicillin-susceptible Staphylococcus aureus (MSSA) infections. Recent retrospective data comparing nafcillin and cefazolin report similar clinical efficacy despite concerns about high inoculum MSSA infections. METHODS: This was a retrospective, non-inferiority, cohort study comparing treatment failure rates between nafcillin and cefazolin in patients with MSSA bacteremia from any source, other than meningitis...
March 8, 2018: Journal of Infection and Public Health
Mathias Schwerdt, Claudia Neumann, Bianca Schwartbeck, Stefanie Kampmeier, Susann Herzog, Dennis Görlich, Angelika Dübbers, Jörg Große-Onnebrink, Christina Kessler, Peter Küster, Holger Schültingkemper, Janina Treffon, Georg Peters, Barbara C Kahl
BACKGROUND: Cystic fibrosis (CF) is an autosomal recessive disease associated with chronic airway infections by Staphylococcus aureus as one of the earliest and most prevalent pathogens. We conducted a retrospective study to determine the S. aureus infection status of CF patients treated since 1994 at two certified CF-centres in Münster, Germany, to get insights into the dynamics of S. aureus airway infection and the clinical impact on lung function on a long-term perspective. MATERIALS AND METHODS: We used data from our microbiological database collected between 1994 and 2016 for patients treated at two centres in Münster, Germany, respectively, to determine the infection status for S...
February 24, 2018: International Journal of Medical Microbiology: IJMM
J S Davis, J Turnidge, S Y C Tong
BACKGROUND AND OBJECTIVES: Antistaphylococcal penicillins (ASPs) are recommended as first line treatment for invasive infections caused by methicillin-susceptible Staphylococcus aureus (MSSA). Cefazolin is an alternative option, but there is theoretical concern about using it due to the fact that some MSSA strains produce beta-lactamases active against cefazolin. We aimed to compare outcomes from patients with MSSA infections treated with flucloxacillin and cefazolin. METHODS: We analysed data from The Australia and New Zealand Co-operative Outcomes of Staphylococcal Sepsis (ANZCOSS) observational study, which included all consecutive unique episodes of Staphylococcus aureus bacteraemia from 27 hospital-based or independent microbiology laboratories from January 2007 to September 2013...
February 27, 2018: International Journal of Antimicrobial Agents
Ayodele Olatimehin, Adebayo O Shittu, Francis C Onwugamba, Alexander Mellmann, Karsten Becker, Frieder Schaumburg
Bats are economically important animals and serve as food sources in some African regions. They can be colonized with the Staphylococcus aureus complex, which includes Staphylococcus schweitzeri and Staphylococcus argenteus . Fecal carriage of S. aureus complex in the straw-colored fruit bat ( Eidolon helvum ) has been described. However, data on their transmission and adaptation in animals and humans are limited. The aim of this study was to investigate the population structure of the S. aureus complex in E...
2018: Frontiers in Microbiology
Kevin M Claunch, Madeline Bush, Christopher R Evans, Jacob A Malmquist, Matthew C Hale, Shauna M McGillivray
ClpX functions as either an independent chaperone or a component of the ClpXP protease, a conserved intracellular protease that acts as a global regulator in the bacterial cell by degrading regulatory proteins, stress response proteins and rate-limiting enzymes. Previously, we found that loss of clpX in Bacillus anthracis Sterne leads to increased susceptibility to antimicrobial agents that target the cell envelope. The aim of this study was to identify genes within the regulatory network of clpX that contribute to antimicrobial resistance...
February 23, 2018: Microbiology
Sheila de Benito, Luis Alou, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, María Luisa Gómez-Lus, Luis Collado, David Sevillano
Background: This study aimed to estimate the prevalence of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) nasopharyngeal carriage among Doctors of Podiatric Medicine (Podiatrists) and to determine the potential risk factors. Methods: A cross-sectional study was carried out in 2016-2017 among 239 podiatrists in Spain. The presence of MSSA, MRSA, and MRSE was determined by microbiological analysis of nasal exudate and antimicrobial susceptibility was determined...
2018: Antimicrobial Resistance and Infection Control
Maryam Ghahremani, Nima Hosseini Jazani, Yaeghob Sharifi
OBJECTIVES: This study aimed to evaluate the frequency, the, phenotypic and molecular characteristics of methicillin- resistant, Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), from clinical specimens at three university teaching hospitals in Urmia-North West of Iran (2012- 2015). METHODS: After identification of the isolates, the antibiotic, susceptibility, the presence of mecA, vanA, pvl genes and staphylococcal, cassette chromosome mec (SCCmec) typing were evaluated...
February 14, 2018: Journal of Global Antimicrobial Resistance
Michael A Pfaller, Michael D Huband, Jennifer Streit, Robert K Flamm, Helio S Sader
Tigecycline and comparators were tested by reference broth microdilution method against 33,348 non-duplicate bacterial isolates collected prospectively in 2016 from medical centers in Asia-Pacific (3,443 isolates), Europe (13,530 isolates), Latin America (3,327 isolates), and United States (13,048 isolates). Among 7,098 Staphylococcus aureus isolates tested, >99.9% were inhibited by ≤0.5 mg/L of tigecycline (MIC50/90 , 0.06/0.12 mg/L), including >99.9% of methicillin-resistant S. aureus and 100.0% of methicillin-susceptible S...
February 1, 2018: International Journal of Antimicrobial Agents
Ronita Adams, Jackie Smith, Stephen Locke, Erica Phillips, Erdal Erol, Craig Carter, Agricola Odoi
BACKGROUND: Antimicrobial resistance limits traditional treatment options and increases costs. It is therefore important to estimate the magnitude of the problem so as to provide empirical data to guide control efforts. The aim of this study was to investigate the burden and patterns of antimicrobial resistance (AMR) among equine Staphylococcus samples submitted to the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) from 1993 to 2009. Retrospective data of 1711 equine Staphylococcus samples submitted to the UKVDL during the time period 1993 to 2009 were included in the study...
February 5, 2018: BMC Veterinary Research
Jun Wang, Lijiao He, Jintong Sha, Haobo Zhu, Liqu Huang, Xiaojiang Zhu, Juan Dong, Guogen Li, Zheng Ge, Rugang Lu, Geng Ma, Yaqi Shi, Yunfei Guo
BACKGROUND: Urinary tract infections (UTIs) are one of most common pediatric infections. The aim of this study was to investigate the etiology and antimicrobial resistance patterns of hospitalized children in our center. METHODS: We conducted a retrospective, descriptive study of all UTIs from January 1, 2013 to November 31, 2016 in children discharged from Nanjing Children's Hospital. The isolated pathogens and their resistance patterns were examined from midstream urine culture...
February 2, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Lei He, Hong-Xiang Zheng, Yanan Wang, Katherine Y Le, Qian Liu, Jun Shang, Yingxin Dai, Hongwei Meng, Xing Wang, Tianming Li, Qianqian Gao, Juanxiu Qin, Huiying Lu, Michael Otto, Min Li
BACKGROUND: Severe infections with highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are a global problem. However, the molecular events defining the evolution of CA-MRSA are still poorly understood. MRSA of sequence type (ST) 398 is known to frequently infect livestock, while ST398 isolates infecting humans are commonly methicillin-susceptible or represent MRSA originating from livestock-associated (LA)-MRSA. METHODS: We used whole genome sequencing of newly detected CA-MRSA ST398 isolates, in comparison to geographically matched LA-MRSA and methicillin-sensitive ST398, to determine their evolutionary history...
January 29, 2018: Genome Medicine
Dong Hyun Oh, Jung Ju Kim, Jinnam Kim, Hye Seong, Se Ju Lee, Yong Chan Kim, Eun Jin Kim, In Young Jung, Woo Yong Jeong, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
BACKGROUND: Studies have shown that the prognosis of the treatment of methicillin-susceptible S. aureus (MSSA) with glycopeptides is inferior compared to treatment with β-lactam. However, there are only few studies comparing treatment with antistaphylococcal penicillin alone to glycopeptide treatment. The aim of this study was to compare the efficacy of nafcillin, an antistaphylococcal penicillin, with that of glycopeptides as a definitive therapy for MSSA bacteremia. METHODS: Patients with MSSA bacteremia recruited from a tertiary referral hospital were enrolled in this retrospective cohort study...
January 30, 2018: BMC Infectious Diseases
Z Chen, X X Lai, L Zhang, J L Fang, J J Ma, G H Li, L Xu, W Yin, Y H Guo
Objective: To investigate the distribution and drug resistance of pathogens in infected organ donors from donation after the citizen death (DCD). Methods: Clinical data of 217 DCD donors from January 2013 to June 2017 were retrospectively analyzed.The phlegm, urine, blood and drainage fluid from all of the donors were routinely cultured.The infection rate of the donors, the composition ratio of pathogens and the distribution of specimen sources were observed and the drug resistance was analyzed. Results: Of all the 217 donors, 128 were infected and the infection rate was 59%...
January 16, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Samane Rahmdel, Saeid Hosseinzadeh, Seyed Shahram Shekarforoush, Sandra Torriani, Veronica Gatto, Safoora Pashangeh
In this study, 28 bacteriocinogenic Staphylococcus strains isolated from goat and sheep milk were subjected to the PCR detection of enterotoxin genes (sea-see), enterotoxin-like toxin Q gene (selq), toxic shock syndrome toxin gene (tst1), and antibiotic resistance genes. They were also evaluated for phenotypic resistance against 10 antibiotics and hemolytic activity. The tyramine and histamine production was investigated using the agar plate assay and capillary zone electrophoretic analysis (CZE). Twenty-five isolates harbored at least one enterotoxin gene...
January 17, 2018: Microbial Pathogenesis
C Q Wang, A M Wang, H Yu, H M Xu, C M Jing, J K Deng, R Z Zhao, C Z Hua, Y H Chen, X J Chen, T Zhang, H Zhang, Y P Chen, J G Yang, A W Lin, S F Wang, Q Cao, X Wang, H L Deng, S C Cao, J H He, W Gao, S Z Han
Objective: To analyze the antimicrobial resistance profile in Chinese children. Methods: This was a prevalence survey. From January 1 through December 31, 2016, the isolates were collected from 10 tertiary children hospitals in China. Antimicrobial susceptibility testing was carried out by routine laboratory methods. The penicillin susceptibility of streptococcus pneumonia and Meropenem susceptibility of gram-negative bacteria were detected by E-test and disk diffusion method respectively. Antimicrobial susceptibility results were interpreted according to the criteria of Clinical and Laboratory Standards Institute (CLSI) Guideline 2016...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Kisei Minami, Runa Terakawa, Masanori Sato, Yasuhiro Shoji, Takehiko Hiroma, Tomohiko Nakamura, Ayaka Horiuchi, Ayaka Otsuka, Noriko Kubota, Eiko Hidaka, Yoshiyuki Kawakami, Meiji Soe Aung, Nobumichi Kobayashi
No abstract text is available yet for this article.
January 15, 2018: Infection Control and Hospital Epidemiology
C H Freitas, J F Mendes, P V Villarreal, P R Santos, C L Gonçalves, H L Gonzales, P S Nascente
Mastitis is an inflammatory process of the udder tissue caused mainly by the bacteria Staphylococcus aureus. The indiscriminate use of antibiotics fosters conditions that favor the selection of resistant microorganisms, suppressing at the same time susceptible forms, causing a serious problem in dairy cattle. Given the importance in performing an antibiogram to select the most adequate antimicrobial therapy, the aim of this study was to identify bacteria isolated from cow's milk with mastitis, in dairy farms situated in the city of Pelotas, Rio Grande do Sul, and to determinate the susceptibility profile of these isolates against the antibiotics used to treat this illness...
January 8, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
Alemayehu Reta, Moges Wubie, Getnet Mekuria
BACKGROUND: Staphylococcus aureus is one of the bacterium that can asymptomatically colonize the human upper respiratory tract (i.e. nose and throat). Carriage of S. aureus, including methicillin resistant S. aureus, is common to children. The aim at this study was to determine the nasal colonization, associated factors and antimicrobial susceptibility patterns of S. aureus isolates among pre-school children in Debre Markos town. METHODS: Institutional-based cross sectional study was conducted...
December 19, 2017: BMC Research Notes
Krisztina Laub, Adrienn Tóthpál, Eszter Kovács, Judit Sahin-Tóth, Andrea Horváth, Szilvia Kardos, Orsolya Dobay
We collected nasal samples from 1,390 healthy 3-7 years old children in Szolnok city, Hungary, in 2012. We detected 476 Staphylococcus aureus isolates from 474 children. In two occasions, two different S. aureus were isolated, based on hemolysis type and pulsed-field gel electrophoresis pattern. S. aureus carriage rate was calculated to be 34.1% similar to others studies. Male gender was found to be a risk factor for carriage by statistical analysis. Altogether, four methicillin-resistant S. aureus (MRSA) strains were detected by mecA polymerase chain reaction, which means 0...
December 18, 2017: Acta Microbiologica et Immunologica Hungarica
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