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Penicillin susceptible staphylococcus

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https://www.readbyqxmd.com/read/28620316/incidence-and-antimicrobial-sensitivity-profiles-of-normal-conjunctiva-bacterial-flora-in-the-central-area-of-china-a-hospital-based-study
#1
Hua Tao, Juan Wang, Lei Li, Hui-Zhi Zhang, Meng-Ping Chen, Le Li
Objective: To study the distribution and patterns of resistance to antimicrobial agents of normal conjunctival bacteria. Materials and Methods: Conjunctival specimens were collected from 8,224 patients and then cultured, which underwent antimicrobial susceptibility test following standard methods. Patients with infectious symptoms such as erythema or oedema and those using systemic or topical antibiotics within 1 month were excluded. Results: In this study, the incidence of isolated bacteria was 24.2%. The middle aged group of 41-65 years presented the lowest rate of bacterial isolation which was 19...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28617524/high-prevalence-of-methicillin-resistant-coagulase-negative-staphylococci-isolated-from-a-university-environment-in-thailand
#2
Rathanin Seng, Udomluk Leungtongkam, Rapee Thummeepak, Wassana Chatdumrong, Sutthirat Sitthisak
The present study was conducted to isolate and characterize the molecular epidemiology of the methicillin-resistant staphylococci in the general university environment, where all five locations; the library, restrooms, canteens, computer rooms and outdoor surfaces, are in common use by a large population of students. We used Mannitol Salt Agar (MSA) supplemented with 4 μg/ml of oxacillin to screen the methicillin-resistant staphylococci. The species level was identified by PCR of rdr (Staphylococcus epidermidis), groESL (Staphylococcus haemolyticus) and nuc (Staphylococcus aureus and Staphylococcus warneri) genes and DNA sequencing of tuf and dnaJ genes...
June 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28603564/a-study-on-the-microbiological-status-of-mineral-drinking-water
#3
Faria Y Aditi, Shafkat S Rahman, Md M Hossain
INTRODUCTION: Water-borne diseases constitute a major health burden in Bangladesh. The objective of this study was to assess the overall quality of mineral water samples that obtained from different shops of Dhaka city. MATERIAL AND METHODS: To achieve the above-mentioned objective, methods of heterotrophic plate count (HPC) and total coliform count (TCC) were applied. Moreover, isolated colony from mineral water samples were characterized by using biochemical and antimicrobial susceptibility tests...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28533107/ehs-matrix-incubated-in-media-containing-penicillin-retains-sufficient-concentrations-of-antibiotic-to-inhibit-growth-of-susceptible-microorganisms
#4
Mark P Murphy, Dagmara A Niedziela, Orla M Keane
In studying the interaction between bacteria and host cells in vitro, the latter are frequently cultured on commercially available biotic matrices such as Matrigel® or Geltrex®. To avoid contamination, host cells are commonly grown in the presence of antibiotics. However, we present here the finding that cell culture on such a matrix in the presence of antibiotics interferes with the outcome of subsequent infection experiments by virtue of diminished bacterial survival. By comparing outcomes for penicillin-susceptible and resistant strains of Staphylococcus aureus, we show that residual penicillin remains in the matrix despite the antibiotics' withdrawal from culture...
May 19, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28525325/epidemiology-of-intramammary-infections-with-staphylococcus-aureus-and-mastitis-streptococci-in-a-dairy-cattle-herd-with-a-history-of-recurrent-clinical-mastitis
#5
H Vlkova, V Babak, I Vrtkova, D Cervinkova, D Marosevic, M Moravkova, Z Jaglic
The aim of the present work was to examine a dairy herd with an anamnesis of recurrent clinical mastitis and decreased milk production. A total of 239 individual cow milk samples originating from asymptomatic cows were collected at four-month intervals and examined mainly for the presence of Staphylococcus aureus and mastitis streptococci using standard cultivation methods. In total, 29.7% and 9.2% samples were positive for S. aureus and mastitis streptococci, respectively. Unlike for mastitis streptococci, the prevalence of animals positive for S...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28522992/molecular-characterization-of-community-acquired-staphylococcus-aureus-bacteremia-in-young-children-in-southern-mozambique-2001-2009
#6
Delfino Vubil, Marcelino Garrine, Ulla Ruffing, Sozinho Acácio, Betuel Sigaúque, Pedro L Alonso, Lutz von Müller, Mathias Herrmann, Inácio Mandomando
Background: The emergence of community-acquired Staphylococcus aureus infections is increasingly recognized as life threating problem worldwide. In Manhiça district, southern Mozambique, S. aureus is the leading cause of community-acquired bacteremia in neonates. Methods: Eighty-four S. aureus isolates from children less than 5 years admitted to Manhiça District Hospital from 2001 to 2009 were randomly selected and genetically characterized by DNA microarray and spa typing. Antimicrobial susceptibility was determined by VITEK 2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28515641/molecular-typing-and-antimicrobial-susceptibility-of-staphylococcus-aureus-strains-isolated-from-raw-milk-cheese-minced-meat-and-chicken-meat-samples
#7
Hayriye Yeşim Can, Mehmet Elmalı, Alper Karagöz
The objectives of this study were: i) to detect the presence of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in raw milk, cheese, beef minced meat, and chicken meat samples; ii) to evaluate the antimicrobial susceptibility of the isolates; and iii) to determine clonal relation among the isolates by using pulsed-field gel electrophoresis (PFGE) method. Therefore, a total of 160 food samples were randomly collected between August 2014 and May 2015 in Hatay province, located in the southern Turkey...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28504093/genetic-characterization-of-staphylococcus-aureus-isolated-from-nasal-samples-of-healthy-ewes-in-tunisia-high-prevalence-of-cc130-and-cc522-lineages
#8
Meriam Ben Said, Mohamed Salah Abbassi, Paula Gómez, Laura Ruiz-Ripa, Senda Sghaier, Oussama El Fekih, Abdennaceur Hassen, Carmen Torres
Staphylococcus aureus is a versatile bacterium, which can infect or colonize a variety of host species. The objective of this study was to characterize S. aureus isolates recovered from nasal swabs of 167 healthy ewes sampled from 12 farms in different areas of Tunisia during the period of 2014-2015. Genetic lineages, virulence factors and antibiotic resistance mechanisms were determined for recovered isolates. S. aureus was detected in 45 out of 167 tested samples (26.9%). All isolates were methicillin-susceptible (MSSA) and the majority of them were susceptible to tested antibiotics with few exceptions (% of resistance): penicillin (8...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28483959/gepotidacin-gsk2140944-in-vitro-activity-against-gram-positive-and-gram-negative-bacteria-mbc-mic-kill-kinetics-checkerboard-pae-sme-tests
#9
R K Flamm, D J Farrell, P R Rhomberg, N E Scangarella-Oman, H S Sader
Gepotidacin is a first in class, novel triazaacenaphthylene antibiotic that inhibits bacterial DNA replication and has in vitro activity against susceptible and drug-resistant pathogens. Reference in vitro methods were used to investigate the minimum inhibitory (MIC) and minimum bactericidal concentration (MBC) activity of gepotidacin and comparator agents against Staphylococcus aureusStreptococcus pneumoniae and Escherichia coli. Gepotidacin in vitro activity was also evaluated using time-kill kinetics, broth microdilution checkerboard methods for synergy testing, and for postantibiotic and subinhibitory effects...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28454589/prevalence-and-antimicrobial-resistance-profile-of-staphylococcus-in-dairy-farms-abattoir-and-humans-in-addis-ababa-ethiopia
#10
Takele Beyene, Halefom Hayishe, Fikru Gizaw, Ashenafi Feyisa Beyi, Fufa Abunna, Bedaso Mammo, Dinka Ayana, Hika Waktole, Reta Duguma Abdi
BACKGROUND: Staphylococcus species cause mastitis and wound infection in livestock and food poisoning in humans through ingestion of contaminated foods, including meat and dairy products. They are evolving pathogens in that they readily acquire drug resistance, and multiple drug-resistant (MDR) isolates are increasing in human and veterinary healthcare. Therefore, this study was conducted to evaluate the prevalence of Staphylococci and their drug resistance in dairy farms and abattoir settings of Addis Ababa...
April 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28451037/colonisation-of-antibiotic-resistant-bacteria-in-a-cohort-of-hiv-infected-children-in-ghana
#11
Eric Sampane-Donkor, Ebenezer Vincent Badoe, Jennifer Adoley Annan, Nicholas Nii-Trebi
Antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. Little is known epidemiologically about antibiotic resistance in relation to people with HIV infection in sub-Saharan Africa. This study investigated the carriage of antibiotic resistant bacteria among HIV infected children at a tertiary hospital in Ghana. One hundred and eighteen HIV positive children were recruited at the Korle-Bu Teaching Hospital in Ghana and nasopharyngeal specimens were collected from them...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28412568/first-report-on-mrsa-cc398-recovered-from-wild-boars-in-the-north-of-portugal-are-we-facing-a-problem
#12
Margarida Sousa, Nuno Silva, Vera Manageiro, Sónia Ramos, António Coelho, David Gonçalves, Manuela Caniça, Carmen Torres, Gilberto Igrejas, Patrícia Poeta
The aim of the present study was to evaluate the resistance of Staphylococcus aureus recovered from wild boars, to analyze their genetic lineages, and to investigate the susceptibility to oxacillin. Samples from mouth and nose of 45 wild boars (Sus scrofa) were collected during hunt activity from November 2012 to January 2013 in the North of Portugal. S. aureus isolates were recovered from 30 of these samples (33%); one isolate/sample was further studied. The susceptibility of the isolates was tested by disk-diffusion test against 14 antimicrobial agents and minimal inhibitory concentration was used to test oxacillin according to EUCAST guidelines...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28399856/factors-associated-with-staphylococcus-aureus-nasal-carriage-and-molecular-characteristics-among-the-general-population-at-a-medical-college-campus-in-guangzhou-south-china
#13
B J Chen, X Y Xie, L J Ni, X L Dai, Y Lu, X Q Wu, H Y Li, Y D Yao, S Y Huang
BACKGROUND: The nasal cavity is the main colonization site of Staphylococcus aureus (S. aureus) in human body. Nasal carriage may be a strong risk factor for some serious infection. There was still limited information about the nasal carriage for S. aureus in south China. METHODS: Sought to determine the prevalence and molecular characteristics of S. aureus nasal carriage, 295 volunteers residing on a medicine campus were investigated and sampled the nasal cavity swab...
April 11, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28394942/evidence-for-the-evolutionary-steps-leading-to-meca-mediated-%C3%AE-lactam-resistance-in-staphylococci
#14
Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rita Sobral, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Henrik Westh, Alexander Tomasz, Hermínia de Lencastre, Maria Miragaia
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA-an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led to the emergence of methicillin-resistant S. aureus (MRSA) pandemics, responsible for high rates of mortality worldwide. Nonetheless, little is known regarding the origin and evolution of mecA. Different mecA homologues have been identified in species belonging to the Staphylococcus sciuri group representing the most primitive staphylococci...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28386280/bacterial-isolates-and-their-antimicrobial-susceptibility-patterns-of-wound-infections-among-inpatients-and-outpatients-attending-the-university-of-gondar-referral-hospital-northwest-ethiopia
#15
Aynalem Mohammed, Mengistu Endris Seid, Teklay Gebrecherkos, Moges Tiruneh, Feleke Moges
Background. The widespread uses of antibiotics, together with the length of time over which they have been available, have led to the emergence of resistant bacterial pathogens contributing to morbidity and mortality. This study was aimed to assess bacterial isolates and their drug susceptibility patterns from inpatients and outpatients with pus and/or wound discharge. Methods. A cross-sectional study was conducted at the University of Gondar Referral Hospital from March to May, 2014. Wound swab samples were collected from each study participant and inoculated into appropriate media...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28373193/high-level-resistance-of-staphylococcus-aureus-to-%C3%AE-lactam-antibiotics-mediated-by-penicillin-binding-protein-4-pbp4
#16
Stephanie M Hamilton, J Andrew N Alexander, Eun Ju Choo, Li Basuino, Thaina M da Costa, Anatoly Severin, Marilyn Chung, Sandra Aedo, Natalie C J Strynadka, Alexander Tomasz, Som S Chatterjee, Henry F Chambers
Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus, has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4 and its promoter were identified in a laboratory-generated mutant strain, CRB, which expresses high-level resistance to β-lactams, including resistance to the new-generation cephalosporins active against methicillin-resistant strains of S. aureus These mutations did not appreciably alter the β-lactam antibiotic binding affinity of purified recombinant mutant PBP4 compared to that of wild-type PBP4...
June 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28359610/methicillin-resistant-staphylococcus-aureus-nasal-carriage-between-healthy-students-of-medical-and-nonmedical-universities
#17
Soleiman Abroo, Nima Hosseini Jazani, Yaeghob Sharifi
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a challenge for public health, and community-acquired (CA) infections seem to be increasing among people in different areas. METHODS: A total of 700 healthy student volunteers residing in dormitories of universities in Urmia, Iran, were enrolled in this study. After identification of the isolates, antibiotic susceptibility, presence of mecA and pvl genes, and staphylococcal cassette chromosome mec (SCCmec) typing were evaluated...
March 27, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28351443/phenotypic-and-molecular-characteristics-of-staphylococcus-aureus-and-methicillin-resistant-staphylococcus-aureus-in-slaughterhouse-pig-related-workers-and-control-workers-in-guangdong-province-china
#18
X L Wang, L Li, S M Li, J Y Huang, Y P Fan, Z J Yao, X H Ye, S D Chen
Pig farmers and veterinarians have high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) due to the occupational livestock exposure, while few reported this association on slaughterhouse workers. We conducted this cross-sectional study to explore the phenotypic and molecular characteristics of S. aureus and MRSA in slaughterhouse pig-related workers and control workers in Guangdong Province, China. Participants were interviewed and provided two nasal swabs. Swabs were tested for S. aureus, and isolates were further tested for antimicrobial susceptibility, virulence genes and multi-locus sequence typing...
July 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28342937/molecular-epidemiology-of-staphylococcus-aureus-nasal-colonization-among-patients-and-their-parents-guardian-in-an-iranian-referral-hospital
#19
Babak Pourakbari, Mahmoud Khodabandeh, Shima Mahmoudi, Farah Sabouni, Alireza Aziz-Ahari, Abbas Bahador, Sepideh Keshavarz Valian, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
INTRODUCTION: Carriage of Staphylococcus aureus in the nose appears to play a key role in the epidemiology and pathogenesis of infection. It is important to investigate the genetic relatedness of S. aureus and MRSA clones in different geographic regions. The aim of this study was to assess the nasal carriage rate of S. aureus, including MRSA strains in both hospitalized children and general adult population (parents/guardian). In addition, antibiotic susceptibility pattern and molecular diversity of S...
June 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28332157/systematic-overdosing-of-oxa-and-cloxacillin-in-severe-infections-treated-in-icu-risk-factors-and-side-effects
#20
Mathilde Neuville, Najoua El-Helali, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Alban Le Monnier, Stéphane Ruckly, Lila Bouadma, Romain Sonneville, Jean-François Timsit, Bruno Mourvillier
BACKGROUND: Oxacillin and cloxacillin are the most frequently used penicillins for the treatment of severe methicillin-susceptible Staphylococcus aureus infections in intensive care units (ICUs), especially endocarditis. International recommendations do not suggest any adaptation of the dosage in case of renal impairment. We wanted to assess the risk factors for overdosing in ICU and the related observed side effects. METHODS: All patients with a therapeutic drug monitoring of oxa- or cloxacillin between 2008 and 2014 were included...
December 2017: Annals of Intensive Care
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