keyword
https://read.qxmd.com/read/38464891/endovascular-treatment-of-renal-vein-thrombosis-in-a-young-patient-with-lung-transplant
#1
Paula Pinto Rodriguez, Anand Brahmandam, Jeffrey Turner, Alfred Lee, Cassius Iyad Ochoa Chaar
Spontaneous renal vein thrombosis is a rare entity. A 28-year-old woman with a history of a double-lung transplant was admitted with flank pain and found to have acute kidney injury. A magnetic resonance venogram demonstrated isolated left renal vein thrombosis with extension into the inferior vena cava. Initial management with therapeutic anticoagulation and hydration was unsuccessful. Thus, pharmacochemical thrombectomy was performed. A temporary suprarenal inferior vena cava filter was placed for intraoperative pulmonary prophylaxis...
April 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38440980/human-otic-progenitor-cell-models-of-congenital-hearing-loss-reveal-potential-pathophysiologic-mechanisms-of-zika-virus-and-cytomegalovirus-infections
#2
JOURNAL ARTICLE
Alfred T Harding, Karen Ocwieja, Minjin Jeong, Yichen Zhang, Valerie Leger, Nairuti Jhala, Konstantina M Stankovic, Lee Gehrke
UNLABELLED: Congenital hearing loss is a common chronic condition affecting children in both developed and developing nations. Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes congenital Zika syndrome. The mechanisms by which HCMV and ZIKV infections cause hearing loss are poorly understood. It is challenging to study human inner ear cells because they are encased in bone and also scarce as autopsy samples. Recent advances in culturing human stem cell-derived otic progenitor cells (OPCs) have allowed us herein to describe successful in vitro infection of OPCs with HCMV and ZIKV, and also to propose potential mechanisms by which each viral infection could affect hearing...
March 5, 2024: MBio
https://read.qxmd.com/read/38430454/providing-0-1-full-time-equivalent-fte-support-to-fellowship-core-faculty-improves-faculty-involvement-in-fellowship-education-and-recruitment
#3
JOURNAL ARTICLE
Ayesha Butt, Jana Christian, Anna Kress, Benjamin Y Lu, Michael E Hurwitz, Sarah B Goldberg, Nikolai A Podoltsev, Luci Gilkes, Alfred Ian Lee
In 2022, the American Council for Graduate Medical Education (ACGME) recommended that core faculty (CF) in medical subspecialty fellowships receive at least 0.1 full-time equivalent (FTE) salary support, with plans to enforce compliance in July 2023. After early feedback raised concerns about potential unintended consequences, ACGME deferred enforcement to July 2024. Hence, there is an urgent need to understand the ramifications of providing FTE support for CF. In 2020, the Yale hematology and medical oncology (HO) fellowship program began providing 0...
March 2, 2024: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://read.qxmd.com/read/38429087/salvage-therapies-including-retreatment-with-bcma-directed-approaches-following-bcma-car-t-relapses-for-multiple-myeloma
#4
JOURNAL ARTICLE
Kevin Robert Reyes, Yen-Chun Liu, Chiung-Yu Huang, Rahul Banerjee, Thomas Martin, Sandy W Wong, Jeffrey Lee Wolf, Shagun Arora, Nina Shah, Ajai Chari, Alfred Chung
For patients with relapsed/refractory multiple myeloma (RRMM) with relapse following B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell therapies (CAR-T), optimal salvage treatment strategies remain unclear. BCMA-directed CAR-T and bispecific antibodies (BsAb) are now commercially available, and the outcomes for retreatment with BCMA-directed approaches are not well-studied. We performed a retrospective analysis of 68 patients with relapsed disease after BCMA-directed CAR-T to evaluate outcomes and responses to salvage therapies...
March 1, 2024: Blood Advances
https://read.qxmd.com/read/38420871/a-machine-learning-based-risk-score-for-prediction-of-infective-endocarditis-among-patients-with-staphylococcus-aureus-bacteraemia-the-sabier-score
#5
JOURNAL ARTICLE
Christopher Koon-Chi Lai, Eman Leung, Yinan He, Ching-Chun Cheung, Mui Oi Yat Oliver, Qinze Yu, Timothy Chun-Man Li, Alfred Lok-Hang Lee, Li Yu, Grace Chung-Yan Lui
BACKGROUND: Early risk assessment is needed to stratify Staphylococcus aureus infective endocarditis (SA-IE) risk among Staphylococcus aureus bacteraemia (SAB) patients to guide clinical management. The objective of this study is to develop a novel risk score independent of subjective clinical judgment and can be used early at the time of blood culture positivity. METHODS: We conducted a retrospective big data analysis from territory-wide electronic data and included hospitalized patients with SAB between 2009 and 2019...
February 29, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38417912/can-a-multicomponent-positive-psychological-intervention-promote-well-being-in-parents-of-young-children-a-randomized-controlled-trial-study-in-hong-kong
#6
JOURNAL ARTICLE
Alfred S Y Lee, Jesus Alfonso Daep Datu, Kevin Kien Hoa Chung, Wing Kai Fung, Ryan Yat Ming Cheung
The present research examined the effects of an Early Advancement in Social-Emotional Health and Positivity (EASP) multicomponent positive psychological intervention on parents' well-being in Hong Kong. Participants were parents of young children (N = 120; Mage  = 37.19 years, SD = 4.71, range = 24-53; female = 95.00%) who participated in the one-month randomized control trial. Participants were randomly assigned into the intervention (n = 50) and waitlist control groups (n = 70)...
February 28, 2024: Family Process
https://read.qxmd.com/read/38413740/a-functional-personalised-oncology-approach-against-metastatic-colorectal-cancer-in-matched-patient-derived-organoids
#7
JOURNAL ARTICLE
Dexter Kai Hao Thng, Lissa Hooi, Bei En Siew, Kai-Yin Lee, Ian Jse-Wei Tan, Bettina Lieske, Norman Sihan Lin, Alfred Wei Chieh Kow, Shi Wang, Masturah Bte Mohd Abdul Rashid, Chermaine Ang, Jasmin Jia Min Koh, Tan Boon Toh, Ker-Kan Tan, Edward Kai-Hua Chow
Globally, colorectal cancer (CRC) is the third most frequently occurring cancer. Progression on to an advanced metastatic malignancy (metCRC) is often indicative of poor prognosis, as the 5-year survival rates of patients decline rapidly. Despite the availability of many systemic therapies for the management of metCRC, the long-term efficacies of these regimens are often hindered by the emergence of treatment resistance due to intratumoral and intertumoral heterogeneity. Furthermore, not all systemic therapies have associated biomarkers that can accurately predict patient responses...
February 27, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38408548/covid-19-infection-is-mild-and-has-minimal-impact-on-lung-function-in-well-vaccinated-and-widely-treated-lung-transplant-recipients
#8
JOURNAL ARTICLE
Samantha L Ennis, Bronwyn J Levvey, Helen V Shingles, Sue J Lee, Gregory I Snell, Bradley J Gardiner
BACKGROUND: COVID-19 has become a common infection affecting lung transplant recipients (LTR), who are at high risk for poor outcomes. Outcomes early in the pandemic were poor, but since the rollout of vaccination and novel COVID-19 treatments, outcomes of LTR have not been well described. Our aim was to evaluate the effect of COVID-19 on the clinical course and lung function trajectory in an Australian cohort of LTR. METHODS: Data was retrospectively collected from LTR with confirmed COVID-19 managed at Alfred Health, between August 2020 and December 2022...
February 24, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38330805/impact-of-low-dose-superparamagnetic-iron-oxide-tracer-for-sentinel-node-biopsy-in-breast-conserving-treatment-on-susceptibility-artefacts-on-magnetic-resonance-imaging-and-contrast-enhanced-mammography
#9
JOURNAL ARTICLE
Elisabeth R M van Haaren, Merel A Spiekerman van Weezelenburg, James van Bastelaar, Alfred Janssen, Thiemo van Nijnatten, Lee H Bouwman, Yvonne L J Vissers, Marc B I Lobbes
BACKGROUND: Residual particles of superparamagnetic iron oxide (SPIO) tracer, used for sentinel node biopsy, cause susceptibility artefacts on breast Magnetic Resonance Imaging (MRI). We investigated the impact of these artefacts on the imaging quality of MRI and explored whether contrast-enhanced mammography (CEM) could be an alternative in the follow-up of breast cancer patients. MATERIALS AND METHODS: Data on patients' characteristics, injection site, presence, size (mm) of artefacts on full-field digital mammography (FFDM)/CEM, MRI after 1 ml SPIO was recorded...
February 5, 2024: Surgical Oncology
https://read.qxmd.com/read/38282647/quantitative-aggregation-of-microbiome-sequencing-data-provides-insights-into-the-associations-between-the-skin-microbiome-and-psoriasis
#10
JOURNAL ARTICLE
Alfred A Chan, Patrick T Tran, Delphine J Lee
Although prior studies have reported distinct skin microbiome profiles associated with psoriasis, differences in methods and analyses limit generalizable conclusions. Individual studies have actually reported conflicting findings; for example, Propionibacterium and Staphylococcus have been significantly associated with both psoriatic lesions and healthy skin. Qualitative reviews have attempted to summarize this body of work, but there is great variability across the studies' findings and methods. To better unify these data, we created a meta-analysis of all publicly available datasets by utilizing a uniform bioinformatics pipeline and reference database to investigate associations of the skin microbiome in psoriasis...
January 2024: JID innovations
https://read.qxmd.com/read/38281467/omeract-2023-systemic-lupus-erythematosus-special-interest-group-winnowing-and-binning-preliminary-candidate-domains-for-the-core-outcome-set
#11
JOURNAL ARTICLE
Wils Nielsen, Vibeke Strand, Lee S Simon, Ioannis Parodis, Alfred H J Kim, Maya Desai, Yvonne Enman, Daniel Wallace, Yashaar Chaichian, Sandra Navarra, Cynthia Aranow, Meggan MacKay, Kimberly Trotter, Oshrat E Tayer-Shifman, Ali Duarte-Garcia, Lai Shan Tam, Manuel F Ugarte-Gil, Guillermo J PonsEstel, John A Reynolds, Mandana Nikpour, Alberta Hoi, Juanita Romero-Diaz, Danaë Papachristos, Amita Aggarwal, Chi Chiu Mok, Keishi Fujio, Rosalind Ramsey-Goldman, Aaron Howe, Behdin Nowrouzi Kia, Dennisse Bonilla, Julian Thumboo, Marta Mosca, Martin Aringer, Sindhu R Johnson, Aaron M Drucker, Eric Morand, Ian Bruce, Zahi Touma
BACKGROUND: The Outcome Measures in Rheumatology (OMERACT) Systemic Lupus Erythematosus (SLE) Working Group held a Special Interest Group (SIG) at the OMERACT 2023 conference in Colorado Springs where SLE collaborators reviewed domain sub-themes generated through qualitative research and literature review. OBJECTIVE: The objective of the SIG and the subsequent meetings of the SLE Working Group was to begin the winnowing and binning of candidate domain sub-themes into a preliminary list of candidate domains that will proceed to the consensus Delphi exercise for the SLE COS...
January 14, 2024: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/38244272/waldenstr%C3%A3-m-macroglobulinemia-lymphoplasmacytic-lymphoma-version-2-2024-nccn-clinical-practice-guidelines-in-oncology
#12
JOURNAL ARTICLE
Shaji K Kumar, Natalie S Callander, Kehinde Adekola, Larry D Anderson, Muhamed Baljevic, Rachid Baz, Erica Campagnaro, Jorge J Castillo, Caitlin Costello, Christopher D'Angelo, Benjamin Derman, Srinivas Devarakonda, Noura Elsedawy, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Hans Lee, Michaela Liedtke, Thomas Martin, James Omel, Timothy Robinson, Aaron Rosenberg, Douglas Sborov, Mark A Schroeder, Daniel Sherbenou, Attaya Suvannasankha, Jason Valent, Asya Nina Varshavsky-Yanovsky, Jenna Snedeker, Rashmi Kumar
The treatment of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) has evolved to include several new options. The NCCN Guidelines for WM/LPL provide a framework on which to base decisions regarding diagnosis, treatment, assessment of response to treatment, and follow-up of both newly diagnosed and previously treated WM/LPL.
January 2024: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/38182499/clinical-significance-of-prostate-cancer-identified-by-transperineal-standard-template-biopsy-in-men-with-nonsuspicious-multiparametric-magnetic-resonance-imaging
#13
JOURNAL ARTICLE
Douglas M Dahl, Shulin Wu, Sharron X Lin, Mengjie Hu, Alfred A Barney, Michelle M Kim, Kristine M Cornejo, Mukesh G Harisinghani, Adam S Feldman, Chin-Lee Wu
OBJECTIVE: Multiparametric magnetic resonance imaging (mpMRI) of the prostate has excellent sensitivity in detecting clinically significant prostate cancer (csCaP). However, whether a negative mpMRI in patients with a clinical suspicion of CaP can omit a confirmatory biopsy remains less understood and without consensus. Transperineal (TP) standard template biopsy (SBx) provides an effective approach to CaP detection. Our aim is to provide a comprehensive understanding of the CaP characteristics detected through TP SBx that are systematically overlooked by mpMRI...
January 4, 2024: Urologic Oncology
https://read.qxmd.com/read/38081133/multiple-myeloma-version-2-2024-nccn-clinical-practice-guidelines-in-oncology
#14
JOURNAL ARTICLE
Shaji K Kumar, Natalie S Callander, Kehinde Adekola, Larry D Anderson, Muhamed Baljevic, Rachid Baz, Erica Campagnaro, Jorge J Castillo, Caitlin Costello, Christopher D'Angelo, Srinivas Devarakonda, Noura Elsedawy, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Hans C Lee, Michaela Liedtke, Thomas Martin, James Omel, Timothy Robinson, Aaron Rosenberg, Douglas Sborov, Mark A Schroeder, Daniel Sherbenou, Attaya Suvannasankha, Jason Valent, Asya Nina Varshavsky-Yanovsky, Rashmi Kumar, Jenna Snedeker
The treatment of relapsed/refractory multiple myeloma (MM) has evolved to include several new options. These include new combinations with second generation proteasome inhibitors (PI); second generation immunomodulators, monoclonal antibodies, CAR T cells, bispecific antibodies, selinexor, venetoclax, and many others. Most patients with MM undergo several cycles of remissions and relapse, and therefore need multiple lines of combination therapies. Selecting treatment options for relapsed/refractory MM requires consideration of resistance status to specific classes, and patient-specific factors such as age and other comorbidities should be considered...
December 2023: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/38071497/patterns-of-breast-reconstruction-and-the-influence-of-a-surgical-multidisciplinary-clinic
#15
JOURNAL ARTICLE
Yuan Tian, Sarah Birks, Sarah Kemp, James C Lee, Michael Weymouth, Jonathan Serpell, Melanie Walker
BACKGROUND: Of the 40% of breast cancer patients who have a mastectomy as part of their surgical treatment, only approximately 29% have a breast reconstruction. In 2016, Alfred Health established a multidisciplinary surgical clinic with breast and plastic surgeons, aiming to improve interdisciplinary collaboration. This study aimed to assess the provision of breast reconstruction at an Australian tertiary public hospital and examine whether the multidisciplinary surgical clinic have improved our reconstructive service provision...
December 10, 2023: ANZ Journal of Surgery
https://read.qxmd.com/read/38016518/evaluating-the-clinical-validity-of-genes-related-to-hemostasis-and-thrombosis-using-the-clingen-gene-curation-framework
#16
JOURNAL ARTICLE
Justyne E Ross, Shruthi Mohan, Jing Zhang, Mia J Sullivan, Loredana Bury, Kristy Lee, Isabella Futchi, Annabelle Frantz, Dara McDougal, Juliana Perez Botero, Marco Cattaneo, Nichola Cooper, Kate Downes, Paolo Gresele, Catriona Keenan, Alfred Lee, Karyn Megy, Pierre-Emmanuel Morange, Neil V Morgan, Harald Schulze, Karen Zimowski, Kathleen Freson, Michele P Lambert
BACKGROUND: Inherited bleeding, thrombotic, and platelet disorders (BTPDs) are a heterogeneous set of diseases, many of which are globally very rare. Over the past five decades, the genetic basis of some of these disorders has been identified, and recently, high-throughput sequencing has become the primary means of identifying disease-causing genetic variants. OBJECTIVES: Knowledge of the clinical validity of a gene-disease relationship is essential to both providing an accurate diagnosis based on results of diagnostic gene panel tests and informing the construction of such panels...
November 26, 2023: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38015449/the-incidence-of-adverse-outcome-in-donors-after-living-donor-liver-transplantation-a-meta-analysis-of-60-829-donors
#17
JOURNAL ARTICLE
Jieling Xiao, Rebecca Wenling Zeng, Wen Hui Lim, Darren Jun Hao Tan, Jie Ning Yong, Clarissa Elysia Fu, Phoebe Tay, Nicholas Syn, Christen En Ya Ong, Elden Yen Hng Ong, Charlotte Hui Chung, Shi Yan Lee, Jia Hong Koh, Margaret Teng, Sameer Prakash, Eunice Xx Tan, Karn Wijarnpreecha, Anand V Kulkarni, Ken Liu, Pojsakorn Danpanichkul, Daniel Q Huang, Mohammad Shadab Siddiqui, Cheng Han Ng, Alfred Wei Chieh Kow, Mark D Muthiah
The scarcity of liver grafts has prompted developments in living donor liver transplantations (LDLT), with previous literature illustrating similar outcomes in recipients compared to deceased donor transplants. However, significant concerns regarding living donor morbidity and mortality have yet to be examined comprehensively. This study aims to provide estimates of the incidence of various outcomes in living liver donors. In this meta-analysis, Medline and Embase were searched from inception to July 2022 for articles assessing the incidence of outcomes in LDLT donors...
November 29, 2023: Liver Transplantation
https://read.qxmd.com/read/37984437/an-extended-tudor-domain-within-vreteno-interconnects-gtsf1l-and-ago3-for-pirna-biogenesis-in-bombyx-mori
#18
JOURNAL ARTICLE
Alfred W Bronkhorst, Chop Y Lee, Martin M Möckel, Sabine Ruegenberg, Antonio M de Jesus Domingues, Shéraz Sadouki, Rossana Piccinno, Tetsutaro Sumiyoshi, Mikiko C Siomi, Lukas Stelzl, Katja Luck, René F Ketting
Piwi-interacting RNAs (piRNAs) direct PIWI proteins to transposons to silence them, thereby preserving genome integrity and fertility. The piRNA population can be expanded in the ping-pong amplification loop. Within this process, piRNA-associated PIWI proteins (piRISC) enter a membraneless organelle called nuage to cleave their target RNA, which is stimulated by Gtsf proteins. The resulting cleavage product gets loaded into an empty PIWI protein to form a new piRISC complex. However, for piRNA amplification to occur, the new RNA substrates, Gtsf-piRISC, and empty PIWI proteins have to be in physical proximity...
November 20, 2023: EMBO Journal
https://read.qxmd.com/read/37938708/predicting-crystal-form-stability-under-real-world-conditions
#19
JOURNAL ARTICLE
Dzmitry Firaha, Yifei Michelle Liu, Jacco van de Streek, Kiran Sasikumar, Hanno Dietrich, Julian Helfferich, Luc Aerts, Doris E Braun, Anders Broo, Antonio G DiPasquale, Alfred Y Lee, Sarah Le Meur, Sten O Nilsson Lill, Walter J Lunsmann, Alessandra Mattei, Pierandrea Muglia, Okky Dwichandra Putra, Mohamed Raoui, Susan M Reutzel-Edens, Sandrine Rome, Ahmad Y Sheikh, Alexandre Tkatchenko, Grahame R Woollam, Marcus A Neumann
The physicochemical properties of molecular crystals, such as solubility, stability, compactability, melting behaviour and bioavailability, depend on their crystal form1 . In silico crystal form selection has recently come much closer to realization because of the development of accurate and affordable free-energy calculations2-4 . Here we redefine the state of the art, primarily by improving the accuracy of free-energy calculations, constructing a reliable experimental benchmark for solid-solid free-energy differences, quantifying statistical errors for the computed free energies and placing both hydrate crystal structures of different stoichiometries and anhydrate crystal structures on the same energy landscape, with defined error bars, as a function of temperature and relative humidity...
November 2023: Nature
https://read.qxmd.com/read/37886519/dda1-a-novel-factor-in-transcription-coupled-repair-modulates-crl4csa-dynamics-at-dna-damage-stalled-rna-polymerase-ii
#20
Alex Pines, Diana Llerena Schiffmacher, Shun-Hsiao Lee, Katarzyna Kliza, Arjan Theil, Masaki Akita, Angela Helfricht, Karel Bezstarosti, Camila Gonzalo-Hansen, Haico van Attikum, Matty Verlaan-de Vries, Alfred Vertegaal, Jan Hoeijmakers, Jurgen Marteijn, Hannes Lans, Jeroen Demmers, Michiel Vermeulen, Titia Sixma, Tomoo Ogi, Wim Vermeulen
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA polymerase II at DNA lesions, which triggers the assembly of the TC-NER-specific proteins CSA, CSB and UVSSA. CSA, a WD40-repeat containing protein, is the substrate receptor subunit of a cullin-RING ubiquitin ligase complex composed of DDB1, CUL4A/B and RBX1 (CRL4 CSA )...
October 12, 2023: Research Square
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