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https://www.readbyqxmd.com/read/29131894/evaluation-of-polycythemia-a-teachable-moment
#1
Mia Djulbegovic, Lydia S Dugdale, Alfred Ian Lee
No abstract text is available yet for this article.
November 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29122859/genome-sequences-of-12-cluster-an-arthrobacter-phages
#2
Julia Y Lee-Soety, Shantanu Bhatt, Tamarah L Adair, J Alfred Bonilla, Karen K Klyczek, Melinda Harrison, Rebecca A Garlena, Charles A Bowman, Daniel A Russell, Welkin H Pope, Deborah Jacobs-Sera, Steven G Cresawn, Graham F Hatfull
Twelve siphoviral phages isolated using Arthrobacter sp. strain ATCC 21022 were sequenced. The phages all have relatively small genomes, ranging from 15,319 to 15,556 bp. All 12 phages are closely related to previously described cluster AN Arthrobacter phages.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29104111/clinical-and-biological-significance-of-mir-193a-3p-targeted-kras-in-colorectal-cancer-pathogenesis
#3
Afraa Mamoori, Riajul Wahab, Farhadul Islam, Katherine Lee, Jelena Vider, Cu-Tai Lu, Vinod Gopalan, Alfred King-Yin Lam
This study was to investigate the expression pattern, mechanisms and clinicopathological implications of miR-193a-3p in colorectal cancer. Fresh frozen tissues from 70 matched colorectal adenocarciomas and the adjacent non-neoplastic mucosae were prospectively collected. Two colorectal cancer cell lines (SW480 and SW48) and a non-neoplastic colon cell line (FHC) were also used. The expression levels of miR193a-3p in the cells and tissues were measured by quantitative real-time polymerase chain reaction. The expression of KRAS protein as a predicted downstream target for miR-193a was studied by immunohistochemistry...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29101381/hot-carrier-cooling-mechanisms-in-halide-perovskites
#4
Jianhui Fu, Qiang Xu, Guifang Han, Bo Wu, Cheng Hon Alfred Huan, Meng Lee Leek, Tze Chien Sum
Halide perovskites exhibit unique slow hot-carrier cooling properties capable of unlocking disruptive perovskite photon-electron conversion technologies (e.g., high-efficiency hot-carrier photovoltaics, photo-catalysis, and photodetectors). Presently, the origins and mechanisms of this retardation remain highly contentious (e.g., large polarons, hot-phonon bottleneck, acoustical-optical phonon upconversion etc.). Here, we investigate the fluence-dependent hot-carrier dynamics in methylammonium lead triiodide using transient absorption spectroscopy, and correlate with theoretical modeling and first-principles calculations...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29097454/complete-genome-sequences-of-arthrobacter-phages-beans-franzy-jordan-piccoletto-shade-and-timinator
#5
Tamarah L Adair, J Alfred Bonilla, Karen K Klyczek, Julia Y Lee-Soety, German Rosas-Acosta, Melinda Harrison, Charles A Bowman, Steven G Cresawn, Rebecca A Garlena, Daniel A Russell, Welkin H Pope, Deborah Jacobs-Sera, Graham F Hatfull
We report here the genome sequences of six newly isolated bacteriophages infecting Arthrobacter sp. ATCC 21022. All six have myoviral morphologies and have double-stranded DNA genomes with circularly permuted ends. The six phages are closely related with average nucleotide identities of 73.4 to 93.0% across genomes lengths of 49,797 to 51,347 bp.
November 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29094630/the-role-of-public-health-nutrition-in-achieving-the-sustainable-development-goals-in-the-asia-pacific-region
#6
Colin Binns, Mi Kyung Lee, Wah Yun Low, Alfred Zerfas
The Sustainable Development Goals (SDGs) replaced the Millennium Development Goals (MDCs) in 2015, which included several goals and targets primarily related to nutrition: to eradicate extreme poverty and hunger and to reduce child mortality and improve maternal health. In the Asia-Pacific Academic Consortium for Public Health (APACPH) member countries as a group, infant and child mortality were reduced by more than 65% between 1990 and 2015, achieving the MDG target of two-thirds reduction, although these goals were not achieved by several smaller countries...
October 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29074107/risk-factors-for-presence-and-severity-of-pulmonary-embolism-in-patients-with-deep-venous-thrombosis
#7
Nancy Huynh, Wassim H Fares, Kirstyn Brownson, Anand Brahmandam, Alfred I Lee, Alan Dardik, Timur Sarac, Cassius Iyad Ochoa Chaar
OBJECTIVE: The Caprini model estimates patients' risk for venous thromboembolism by 30 different factors. Hemodynamically significant pulmonary embolism (PE), defined as high-risk (massive) or intermediate-risk (submassive) PE, has high morbidity and mortality rates. This study tests whether the Caprini model and deep venous thrombosis (DVT) characteristics correlate with the prevalence of PE and hemodynamically significant PE in patients with DVT. METHODS: A retrospective review of patients diagnosed with DVT between January 2013 and August 2014 in a tertiary care center was performed...
October 23, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28951389/genetically-determined-plasma-lipid-levels-and-risk-of-diabetic-retinopathy-a-mendelian-randomization-study
#8
Lucia Sobrin, Yong He Chong, Qiao Fan, Alfred Gan, Lynn K Stanwyck, Georgia Kaidonis, Jamie E Craig, Jihye Kim, Wen-Ling Liao, Yu-Chuen Huang, Wen-Jane Lee, Yi-Jen Hung, Xiuqing Guo, Yang Hai, Eli Ipp, Samuela Pollack, Heather Hancock, Alkes Price, Alan Penman, Paul Mitchell, Gerald Liew, Albert V Smith, Vilmundur Gudnason, Gavin Tan, Barbara E K Klein, Jane Kuo, Xiaohui Li, Mark W Christiansen, Bruce M Psaty, Kevin Sandow, Richard A Jensen, Ronald Klein, Mary Frances Cotch, Jie Jin Wang, Yucheng Jia, Ching J Chen, Yii-Der Ida Chen, Jerome I Rotter, Fuu-Jen Tsai, Craig L Hanis, Kathryn P Burdon, Tien Yin Wong, Ching-Yu Cheng
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization (MR) approach. We pooled genome-wide association studies summary statistics from 18 studies for 2 DR phenotypes: any DR (N=2,969 case; 4,096 controls) and severe DR, (N=1,277 cases; 3,980 controls). Previously identified lipid-associated single nucleotide polymorphisms (SNPs) served as instrumental variables...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28888266/new-york-heart-association-class-and-the-survival-benefit-from-primary-prevention-implantable-cardioverter-defibrillators-a-pooled-analysis-of-4-randomized-controlled-trials
#9
REVIEW
Daniel J Friedman, Sana M Al-Khatib, Emily P Zeitler, JooYoon Han, Gust H Bardy, Jeanne E Poole, J Thomas Bigger, Alfred E Buxton, Arthur J Moss, Kerry L Lee, Richard Steinman, Paul Dorian, Riccardo Cappato, Alan H Kadish, Peter J Kudenchuk, Daniel B Mark, Lurdes Y T Inoue, Gillian D Sanders
BACKGROUND: Primary prevention implantable cardioverter defibrillator (ICD) reduce all-cause mortality by reducing sudden cardiac death. There are conflicting data regarding whether patients with more advanced heart failure derive ICD benefit owing to the competing risk of nonsudden death. METHODS: We performed a patient-level meta-analysis of New York Heart Association (NYHA) class II/III heart failure patients (left ventricular ejection fraction ≤35%) from 4 primary prevention ICD trials (MADIT-I, MADIT-II, DEFINITE, SCD-HeFT)...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28864826/igsf21-promotes-differentiation-of-inhibitory-synapses-via-binding-to-neurexin2%C3%AE
#10
Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W Linhoff, Hideto Takahashi
Coordinated development of excitatory and inhibitory synapses is essential for higher brain function, and impairment in this development is associated with neuropsychiatric disorders. In contrast to the large body of accumulated evidence regarding excitatory synapse development, little is known about synaptic adhesion and organization mechanisms underlying inhibitory synapse development. Through unbiased expression screens and proteomics, we identified immunoglobulin superfamily member 21 (IgSF21) as a neurexin2α-interacting membrane protein that selectively induces inhibitory presynaptic differentiation...
September 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28862757/the-ccctc-binding-factor-ctcf-forkhead-box-protein-m1-axis-regulates-tumour-growth-and-metastasis-in-hepatocellular-carcinoma
#11
Bin Zhang, Yajing Zhang, Xiaoping Zou, Anthony Wh Chan, Rui Zhang, Terence Kin-Wah Lee, Hang Liu, Eunice Yuen-Ting Lau, Nicole Pui-Yu Ho, Paul Bs Lai, Yue-Sun Cheung, Ka-Fai To, Hoi Kin Wong, Kwong Wai Choy, Vincent W Keng, Larry Mc Chow, Kenrick Ky Chan, Alfred S Cheng, Ben Cb Ko
CCCTC-binding factor (CTCF) is a DNA-binding protein that interacts with a large number of highly divergent target sequences throughout the genome. It is implicated in a variety of functions, including chromatin organization and transcriptional control. The functional role of CTCF in tumour pathogenesis remains elusive. We showed that CTCF is frequently upregulated in a subset of primary hepatocellular carcinomas (HCCs) as compared with non-tumoural liver. Overexpression of CTCF was associated with shorter disease-free survival of patients...
September 1, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28744959/predicting-appropriate-shocks-in-patients-with-heart-failure-patient-level-meta-analysis-from-scd-heft-and-madit-ii
#12
Emily P Zeitler, Sana M Al-Khatib, Daniel J Friedman, Joo Yoon Han, Jeanne E Poole, Gust H Bardy, J Thomas Bigger, Alfred E Buxton, Arthur J Moss, Kerry L Lee, Paul Dorian, Riccardo Cappato, Alan H Kadish, Peter J Kudenchuk, Daniel B Mark, Lurdes Y T Inoue, Gillian D Sanders
BACKGROUND: No precise tools exist to predict appropriate shocks in patients with a primary prevention ICD. We sought to identify characteristics predictive of appropriate shocks in patients with a primary prevention implantable cardioverter defibrillator (ICD). METHODS: Using patient-level data from the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) and the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), we identified patients with any appropriate shock...
November 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28743888/multiplication-rate-variation-in-the-human-malaria-parasite-plasmodium-falciparum
#13
Lee Murray, Lindsay B Stewart, Sarah J Tarr, Ambroise D Ahouidi, Mahamadou Diakite, Alfred Amambua-Ngwa, David J Conway
It is important to understand intrinsic variation in asexual blood stage multiplication rates of the most virulent human malaria parasite, Plasmodium falciparum. Here, multiplication rates of long-term laboratory adapted parasite clones and new clinical isolates were measured, using a newly standardised assay of growth from low starting density in replicate parallel cultures with erythrocytes from multiple different donors, across multiple cycles. Multiplication rates of long-term established clones were between 7...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715480/tales-of-diversity-genomic-and-morphological-characteristics-of-forty-six-arthrobacter-phages
#14
Karen K Klyczek, J Alfred Bonilla, Deborah Jacobs-Sera, Tamarah L Adair, Patricia Afram, Katherine G Allen, Megan L Archambault, Rahat M Aziz, Filippa G Bagnasco, Sarah L Ball, Natalie A Barrett, Robert C Benjamin, Christopher J Blasi, Katherine Borst, Mary A Braun, Haley Broomell, Conner B Brown, Zachary S Brynell, Ashley B Bue, Sydney O Burke, William Casazza, Julia A Cautela, Kevin Chen, Nitish S Chimalakonda, Dylan Chudoff, Jade A Connor, Trevor S Cross, Kyra N Curtis, Jessica A Dahlke, Bethany M Deaton, Sarah J Degroote, Danielle M DeNigris, Katherine C DeRuff, Milan Dolan, David Dunbar, Marisa S Egan, Daniel R Evans, Abby K Fahnestock, Amal Farooq, Garrett Finn, Christopher R Fratus, Bobby L Gaffney, Rebecca A Garlena, Kelly E Garrigan, Bryan C Gibbon, Michael A Goedde, Carlos A Guerrero Bustamante, Melinda Harrison, Megan C Hartwell, Emily L Heckman, Jennifer Huang, Lee E Hughes, Kathryn M Hyduchak, Aswathi E Jacob, Machika Kaku, Allen W Karstens, Margaret A Kenna, Susheel Khetarpal, Rodney A King, Amanda L Kobokovich, Hannah Kolev, Sai A Konde, Elizabeth Kriese, Morgan E Lamey, Carter N Lantz, Jonathan S Lapin, Temiloluwa O Lawson, In Young Lee, Scott M Lee, Julia Y Lee-Soety, Emily M Lehmann, Shawn C London, A Javier Lopez, Kelly C Lynch, Catherine M Mageeney, Tetyana Martynyuk, Kevin J Mathew, Travis N Mavrich, Christopher M McDaniel, Hannah McDonald, C Joel McManus, Jessica E Medrano, Francis E Mele, Jennifer E Menninger, Sierra N Miller, Josephine E Minick, Courtney T Nabua, Caroline K Napoli, Martha Nkangabwa, Elizabeth A Oates, Cassandra T Ott, Sarah K Pellerino, William J Pinamont, Ross T Pirnie, Marie C Pizzorno, Emilee J Plautz, Welkin H Pope, Katelyn M Pruett, Gabbi Rickstrew, Patrick A Rimple, Claire A Rinehart, Kayla M Robinson, Victoria A Rose, Daniel A Russell, Amelia M Schick, Julia Schlossman, Victoria M Schneider, Chloe A Sells, Jeremy W Sieker, Morgan P Silva, Marissa M Silvi, Stephanie E Simon, Amanda K Staples, Isabelle L Steed, Emily L Stowe, Noah A Stueven, Porter T Swartz, Emma A Sweet, Abigail T Sweetman, Corrina Tender, Katrina Terry, Chrystal Thomas, Daniel S Thomas, Allison R Thompson, Lorianna Vanderveen, Rohan Varma, Hannah L Vaught, Quynh D Vo, Zachary T Vonberg, Vassie C Ware, Yasmene M Warrad, Kaitlyn E Wathen, Jonathan L Weinstein, Jacqueline F Wyper, Jakob R Yankauskas, Christine Zhang, Graham F Hatfull
The vast bacteriophage population harbors an immense reservoir of genetic information. Almost 2000 phage genomes have been sequenced from phages infecting hosts in the phylum Actinobacteria, and analysis of these genomes reveals substantial diversity, pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here, we describe the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain...
2017: PloS One
https://www.readbyqxmd.com/read/28703439/laparoendoscopic-single-site-surgery-in-inguinal-hernia-repair
#15
REVIEW
Alfred Allen E Buenafe, Alembert C Lee-Ong
Laparoendoscopic single-site surgery (LESS) for laparoscopic inguinal hernia repair (IHR) offers the potential for excellent cosmetic outcomes and maximization of the inherent advantages of minimally invasive surgery. LESS IHR is associated with a steep learning curve, which is attributable to both the IHR technique itself and the single-site technique. The technical obstacles in the single-site technique may be mitigated by employing certain maneuvers and strategies that minimize clashing between instruments and improve freedom of movement...
August 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28688814/proceedings-beyond-ultrasound-first-forum-on-improving-the-quality-of-ultrasound-imaging-in-obstetrics-and-gynecology
#16
Beryl R Benacerraf, Katherine K Minton, Carol B Benson, Bryann S Bromley, Brian D Coley, Peter M Doubilet, Wesley Lee, Samuel H Maslak, John S Pellerito, James J Perez, Eric Savitsky, Norman A Scarborough, Joseph Wax, Alfred Z Abuhamad
The Beyond Ultrasound First Forum was conceived to increase awareness that the quality of obstetric and gynecologic ultrasound can be improved, and is inconsistent throughout the country, likely due to multiple factors, including the lack of a standardized curriculum and competency assessment in ultrasound teaching. The forum brought together representatives from many professional associations; the imaging community including radiology, obstetrics and gynecology, and emergency medicine among others; in addition to government agencies, insurers, industry, and others with common interest in obstetric and gynecologic ultrasound...
July 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28659837/paper-vs-pixel-can-we-use-a-pen-and-paper-method-to-measure-athletes-implicit-doping-attitude
#17
Derwin K C Chan, Alfred S Y Lee, Tracy C W Tang, Daniel F Gucciardi, Patrick S H Yung, Martin S Hagger
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28659392/change-in-vision-related-quality-of-life-and-influencing-factors-in-asians-receiving-treatment-for-neovascular-age-related-macular-degeneration
#18
Eva K Fenwick, Gemmy Chui Ming Cheung, Alfred Tl Gan, Gavin Tan, Shu Yen Lee, Doric Wong, Ian Yeo, Ranjana Mathur, Tien Y Wong, Ecosse L Lamoureux
AIM: To assess the change in vision-related quality of life (VRQoL) after treatment for neovascular age-related macular degeneration (nAMD) and factors influencing this change in an Asian population. METHODS: In this longitudinal study, 116 patients (mean age±SD=66.5±9.9 years; 59.5% male) who underwent treatment for nAMD were recruited from a tertiary eye centre in Singapore. Best-corrected visual acuity (BCVA) and the Impact of Vision Impairment (IVI) questionnaire were evaluated at baseline and month 12...
June 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28623981/characteristics-of-provoked-deep-venous-thrombosis-in-a-tertiary-care-center
#19
Kirstyn E Brownson, Anand Brahmandam, Nancy Huynh, Jesse Reynolds, Wassim H Fares, Alfred Ian Lee, Alan Dardik, Cassius Iyad Ochoa Chaar
OBJECTIVE: Provoked deep venous thrombosis (DVT) is precipitated by a specific event. This paper compares the characteristics of provoked DVT in patients with transient risk (TR) factors and patients with continuous risk (CR) factors. METHODS: A retrospective review of records of all consecutive patients diagnosed with DVT between January 2013 and August 2014 was performed. Patients with provoked DVT were included in the TR group if the provoking event resolved in 2 weeks and they did not have ongoing risk of thrombosis...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28608921/whole-exome-sequencing-reveals-critical-genes-underlying-metastasis-in-oesophageal-squamous-cell-carcinoma
#20
Wei Dai, Josephine Mun Yee Ko, Sheyne Sta Ana Choi, Zhouyou Yu, Luwen Ning, Hong Zheng, Vinod Gopalan, Kin Tak Chan, Nikki Pui-Yue Lee, Kwok Wah Chan, Simon Ying-Kit Law, Alfred King-Yin Lam, Maria Li Lung
Oesophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers, owing to a high frequency of metastasis. However, little is known about the genomic landscape of metastatic ESCC. To identify the genetic alterations that underlie ESCC metastasis, whole-exome sequencing was performed for 41 primary tumours and 15 lymph nodes (LNs) with metastatic ESCCs. Eleven cases included matched primary tumours, synchronous LN metastases, and non-neoplastic mucosa. Approximately 50-76% of the mutations identified in primary tumours appeared in the synchronous LN metastases...
August 2017: Journal of Pathology
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