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Amanda J Ashdown, Mark W Scerbo, Lee A Belfore, Stephen S Davis, Alfred Z Abuhamad
Objective This study examined the ability of clinicians to correctly categorize images of fetal heart rate (FHR) variability with and without the use of exemplars. Study Design A sample of 33 labor and delivery clinicians inspected static FHR images and categorized them into one of four categories defined by the National Institute of Child Health and Human Development (NICHD) based on the amount of variability within absent, minimal, moderate, or marked ranges. Participants took part in three conditions: two in which they used exemplars representing FHR variability near the center or near the boundaries of each range, and a third control condition with no exemplars...
October 2016: American Journal of Perinatology Reports
Yusuke Naito, Alfred Kihoon Lee, Hideto Takahashi
Tropomyosin-receptor-kinase (Trk) receptors have been extensively studied for their roles in kinase-dependent signaling cascades in nervous system development. Synapse organization is coordinated by trans-synaptic interactions of various cell adhesion proteins, a representative example of which is the neurexin-neuroligin complex. Recently, a novel role for TrkC as a synapse organizing protein has been established. Post-synaptic TrkC binds to pre-synaptic type-IIa receptor-type protein tyrosine phosphatase sigma (PTPσ)...
September 30, 2016: Neuroscience Research
Alexie Papanicolaou, Marc F Schetelig, Peter Arensburger, Peter W Atkinson, Joshua B Benoit, Kostas Bourtzis, Pedro Castañera, John P Cavanaugh, Hsu Chao, Christopher Childers, Ingrid Curril, Huyen Dinh, HarshaVardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Markus Friedrich, Giuliano Gasperi, Scott Geib, Georgios Georgakilas, Richard A Gibbs, Sarah D Giers, Ludvik M Gomulski, Miguel González-Guzmán, Ana Guillem-Amat, Yi Han, Artemis G Hatzigeorgiou, Pedro Hernández-Crespo, Daniel S T Hughes, Jeffery W Jones, Dimitra Karagkouni, Panagiota Koskinioti, Sandra L Lee, Anna R Malacrida, Mosè Manni, Kostas Mathiopoulos, Angela Meccariello, Shwetha C Murali, Terence D Murphy, Donna M Muzny, Georg Oberhofer, Félix Ortego, Maria D Paraskevopoulou, Monica Poelchau, Jiaxin Qu, Martin Reczko, Hugh M Robertson, Andrew J Rosendale, Andrew E Rosselot, Giuseppe Saccone, Marco Salvemini, Grazia Savini, Patrick Schreiner, Francesca Scolari, Paolo Siciliano, Sheina B Sim, George Tsiamis, Enric Ureña, Ioannis S Vlachos, John H Werren, Ernst A Wimmer, Kim C Worley, Antigone Zacharopoulou, Stephen Richards, Alfred M Handler
BACKGROUND: The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and manipulation of medfly has been subject to intensive study in an effort to improve SIT efficacy and other aspects of IPM control...
2016: Genome Biology
Hong-Jai Park, Hyeon-Soo Park, Jae-Ung Lee, Alfred L M Bothwell, Je-Min Choi
Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been recognized to regulate adaptive immunity through Th17 differentiation, Treg functions, and TFH responses. However, its role in adaptive immunity and autoimmune disease is still not clear, possibly due to sexual differences. Here, we investigated in vitro treatment study with the PPARγ agonist pioglitazone to compare Th1, Th2, and Th17 differentiation in male and female mouse splenic T cells. Pioglitazone treatment significantly inhibited various effector T cell differentiations including Th1, Th2, and Th17 cells from female naïve T cells, but it selectively reduced IL-17 production in male Th17 differentiation...
2016: International Journal of Molecular Sciences
Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Yixin Xiao, Danlei Wang, Audrey Tze Ting Khoo, Levena Sani, Hoang-Dai Tran, Paul Kim, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Bing Lim, Hyunsoo Shawn Je
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders. Patient-derived interneurons could provide a foundation for studying the pathogenesis of these diseases as well as for identifying potential therapeutic targets. Here, we identified a set of genetic factors that could robustly induce human pluripotent stem cells (hPSCs) into GABAergic neurons (iGNs) with high efficiency. We demonstrated that the human iGNs express neurochemical markers and exhibit mature electrophysiological properties within 6-8 weeks...
August 16, 2016: Cell Reports
Junghyun Jo, Yixin Xiao, Alfred Xuyang Sun, Engin Cukuroglu, Hoang-Dai Tran, Jonathan Göke, Zi Ying Tan, Tzuen Yih Saw, Cheng-Peow Tan, Hidayat Lokman, Younghwan Lee, Donghoon Kim, Han Seok Ko, Seong-Oh Kim, Jae Hyeon Park, Nam-Joon Cho, Thomas M Hyde, Joel E Kleinman, Joo Heon Shin, Daniel R Weinberger, Eng King Tan, Hyunsoo Shawn Je, Huck-Hui Ng
Recent advances in 3D culture systems have led to the generation of brain organoids that resemble different human brain regions; however, a 3D organoid model of the midbrain containing functional midbrain dopaminergic (mDA) neurons has not been reported. We developed a method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains distinct layers of neuronal cells expressing characteristic markers of human midbrain. Importantly, we detected electrically active and functionally mature mDA neurons and dopamine production in our 3D midbrain-like organoids (MLOs)...
August 4, 2016: Cell Stem Cell
Kavitha Thevakumar, Josephine Rebecca Chandren, Guillermo Ignacio Perez-Perez, Eng Guan Chua, Lay Kek Teh, Mohd Zaki Salleh, Jin Ai Mary Anne Tan, Alex Hwong Ruey Leow, Khean Lee Goh, Alfred Chin Yen Tay, Barry J Marshall, Jamuna Vadivelu, Mun Fai Loke, Li Ping Wong
The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia...
2016: PloS One
Rebecca K Papas, Benson N Gakinya, Michael M Mwaniki, Alfred K Keter, Hana Lee, Michelle P Loxley, Debra A Klein, John E Sidle, Steve Martino, Joyce B Baliddawa, Kathryn L Schlaudt, Stephen A Maisto
BACKGROUND: To counteract the syndemics of HIV and alcohol in Sub-Saharan Africa, international collaborations have developed interventions to reduce alcohol consumption. Reliable and accurate methods are needed to estimate alcohol use outcomes. A direct alcohol biomarker called phosphatidylethanol (PEth) has been shown to validate heavy, daily drinking, but the literature indicates mixed results for moderate and nondaily drinkers, including among HIV-infected populations. This study examined the associations of the PEth biomarker with self-report alcohol use at 2 time points in 127 HIV-infected outpatient drinkers in western Kenya...
August 2016: Alcoholism, Clinical and Experimental Research
María J Marquine, Matthew D Grilli, Steven Z Rapcsak, Alfred W Kaszniak, Lee Ryan, Katrin Walther, Elizabeth L Glisky
Functional neuroimaging has revealed that in healthy adults retrieval of personal trait knowledge is associated with increased activation in the medial prefrontal cortex (mPFC). Separately, neuropsychology has shown that the self-referential nature of memory can be disrupted in individuals with mPFC lesions. However, it remains unclear whether damage to the mPFC impairs retrieval of personal trait knowledge. Therefore, in this neuropsychological case study we investigated the integrity of personal trait knowledge in J...
August 2016: Neuropsychologia
Hong-Jai Park, Hyeon-Soo Park, Jae-Ung Lee, Alfred L M Bothwell, Je-Min Choi
Peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipocyte differentiation, has recently been connected with effector T cells, though its role is still not clear. Here, we investigated the roles of PPARγ in follicular helper T (TFH) cell responses regarding gender specificity. NP-OVA immunization in female but not male CD4-PPARγ(KO) mice induced higher proportions of TFH cells and germinal center (GC) B cells following immunization than were seen in wild type mice. Treatment with the PPARγ agonist pioglitazone significantly reduced TFH cell responses in female mice while pioglitazone and estradiol (E2) co-treatment ameliorated TFH cells and GC responses in male mice...
2016: Scientific Reports
Alfred A Chan, Mina Bashir, Magali N Rivas, Karen Duvall, Peter A Sieling, Thomas R Pieber, Parag A Vaishampayan, Susan M Love, Delphine J Lee
The microbiome impacts human health and disease. Until recently, human breast tissue and milk were presumed to be sterile. Here, we investigated the presence of microbes in the nipple aspirate fluid (NAF) and their potential association with breast cancer. We compared the NAF microbiome between women with a history of breast cancer (BC) and healthy control women (HC) using 16S rRNA gene amplicon sequencing. The NAF microbiome from BC and HC showed significant differences in community composition. Two Operational Taxonomic Units (OTUs) showed differences in relative abundances between NAF collected from BC and HC...
2016: Scientific Reports
Alfred I Lee, Cassius I Ochoa Chaar
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 24-year-old woman with no..
June 2, 2016: New England Journal of Medicine
Heather Greenlee, Alfred I Neugut, Laura Falci, Grace Clarke Hillyer, Donna Buono, Jeanne S Mandelblatt, Janise M Roh, Isaac J Ergas, Marilyn L Kwan, Marion Lee, Wei Yann Tsai, Zaixing Shi, Lois Lamerato, Lawrence H Kushi, Dawn L Hershman
IMPORTANCE: Not all women initiate clinically indicated breast cancer adjuvant treatment. It is important for clinicians to identify women at risk for noninitiation. OBJECTIVE: To determine whether complementary and alternative medicine (CAM) use is associated with decreased breast cancer chemotherapy initiation. DESIGN, SETTING, AND PARTICIPANTS: In this multisite prospective cohort study (the Breast Cancer Quality of Care [BQUAL] study) designed to examine predictors of breast cancer treatment initiation and adherence, 685 women younger than 70 years with nonmetastatic invasive breast cancer were recruited from Columbia University Medical Center, Kaiser Permanente Northern California, and Henry Ford Health System and enrolled between May 2006 and July 31, 2010...
September 1, 2016: JAMA Oncology
Katherine Ting-Wei Lee, Juan-King Tan, Alfred King-Yin Lam, Sook-Yee Gan
Despite significant medical advancement, nasopharyngeal carcinoma (NPC) remains one of the most difficult cancers to detect and treat where it continues to prevail especially among the Asian population. miRNAs could act as tumour suppressor genes or oncogenes in NPC. They play important roles in the pathogenesis of NPC by regulating specific target genes which are involved in various cellular processes and pathways. In particular, studies on miRNAs related to the Epstein Barr virus (EBV)-encoded latent membrane protein one (LMP1) and EBVmiRNA- BART miRNA confirmed the link between EBV and NPC...
July 2016: Critical Reviews in Oncology/hematology
Do Hee Lee, Michael Y Sherman, Alfred L Goldberg
Cytoplasmic Hsp70s of SSA family, especially Ssa1p, are involved in the degradation of a variety of misfolded proteins in yeast. However the importance of other Ssa proteins in this process is unclear. To clarify the role(s) of individual Ssa proteins in proteolysis, we measured the breakdown of various cell proteins in mutants lacking different Ssa proteins. In mutants lacking Ssa1p and Ssa2p, the proteasomal degradation of short-lived proteins was reduced, which was not restored fully by the over-expression of Ssa1p...
June 17, 2016: Biochemical and Biophysical Research Communications
A Adare, C Aidala, N N Ajitanand, Y Akiba, H Al-Bataineh, J Alexander, M Alfred, A Angerami, K Aoki, N Apadula, Y Aramaki, H Asano, E T Atomssa, R Averbeck, T C Awes, B Azmoun, V Babintsev, M Bai, G Baksay, L Baksay, N S Bandara, B Bannier, K N Barish, B Bassalleck, A T Basye, S Bathe, V Baublis, C Baumann, A Bazilevsky, M Beaumier, S Beckman, S Belikov, R Belmont, R Bennett, A Berdnikov, Y Berdnikov, J H Bhom, D S Blau, J S Bok, K Boyle, M L Brooks, J Bryslawskyj, H Buesching, V Bumazhnov, G Bunce, S Butsyk, S Campbell, A Caringi, C-H Chen, C Y Chi, M Chiu, I J Choi, J B Choi, R K Choudhury, P Christiansen, T Chujo, P Chung, O Chvala, V Cianciolo, Z Citron, B A Cole, Z Conesa Del Valle, M Connors, M Csanád, T Csörgő, T Dahms, S Dairaku, I Danchev, T W Danley, K Das, A Datta, M S Daugherity, G David, M K Dayananda, K DeBlasio, K Dehmelt, A Denisov, A Deshpande, E J Desmond, K V Dharmawardane, O Dietzsch, A Dion, P B Diss, J H Do, M Donadelli, L D'Orazio, O Drapier, A Drees, K A Drees, J M Durham, A Durum, D Dutta, S Edwards, Y V Efremenko, F Ellinghaus, T Engelmore, A Enokizono, H En'yo, S Esumi, B Fadem, N Feege, D E Fields, M Finger, M Finger, F Fleuret, S L Fokin, Z Fraenkel, J E Frantz, A Franz, A D Frawley, K Fujiwara, Y Fukao, T Fusayasu, C Gal, P Gallus, P Garg, I Garishvili, H Ge, F Giordano, A Glenn, H Gong, M Gonin, Y Goto, R Granier de Cassagnac, N Grau, S V Greene, G Grim, M Grosse Perdekamp, T Gunji, H-Å Gustafsson, T Hachiya, J S Haggerty, K I Hahn, H Hamagaki, J Hamblen, H F Hamilton, R Han, S Y Han, J Hanks, S Hasegawa, T O S Haseler, K Hashimoto, E Haslum, R Hayano, X He, M Heffner, T K Hemmick, T Hester, J C Hill, M Hohlmann, R S Hollis, W Holzmann, K Homma, B Hong, T Horaguchi, D Hornback, T Hoshino, N Hotvedt, J Huang, S Huang, T Ichihara, R Ichimiya, Y Ikeda, K Imai, M Inaba, A Iordanova, D Isenhower, M Ishihara, M Issah, D Ivanishchev, Y Iwanaga, B V Jacak, M Jezghani, J Jia, X Jiang, J Jin, B M Johnson, T Jones, K S Joo, D Jouan, D S Jumper, F Kajihara, J Kamin, S Kanda, J H Kang, J Kapustinsky, K Karatsu, M Kasai, D Kawall, M Kawashima, A V Kazantsev, T Kempel, J A Key, V Khachatryan, A Khanzadeev, K M Kijima, J Kikuchi, A Kim, B I Kim, C Kim, D J Kim, E-J Kim, G W Kim, M Kim, Y-J Kim, B Kimelman, E Kinney, Á Kiss, E Kistenev, R Kitamura, J Klatsky, D Kleinjan, P Kline, T Koblesky, L Kochenda, B Komkov, M Konno, J Koster, D Kotov, A Král, A Kravitz, G J Kunde, K Kurita, M Kurosawa, Y Kwon, G S Kyle, R Lacey, Y S Lai, J G Lajoie, A Lebedev, D M Lee, J Lee, K B Lee, K S Lee, S Lee, S H Lee, M J Leitch, M A L Leite, X Li, P Lichtenwalner, P Liebing, S H Lim, L A Linden Levy, T Liška, H Liu, M X Liu, B Love, D Lynch, C F Maguire, Y I Makdisi, M Makek, M D Malik, A Manion, V I Manko, E Mannel, Y Mao, H Masui, F Matathias, M McCumber, P L McGaughey, D McGlinchey, C McKinney, N Means, A Meles, M Mendoza, B Meredith, Y Miake, T Mibe, A C Mignerey, K Miki, A Milov, D K Mishra, J T Mitchell, S Miyasaka, S Mizuno, A K Mohanty, P Montuenga, H J Moon, T Moon, Y Morino, A Morreale, D P Morrison, T V Moukhanova, T Murakami, J Murata, A Mwai, S Nagamiya, K Nagashima, J L Nagle, M Naglis, M I Nagy, I Nakagawa, H Nakagomi, Y Nakamiya, K R Nakamura, T Nakamura, K Nakano, S Nam, C Nattrass, P K Netrakanti, J Newby, M Nguyen, M Nihashi, T Niida, S Nishimura, R Nouicer, T Novák, N Novitzky, A S Nyanin, C Oakley, E O'Brien, S X Oda, C A Ogilvie, M Oka, K Okada, Y Onuki, J D Orjuela Koop, J D Osborn, A Oskarsson, M Ouchida, K Ozawa, R Pak, V Pantuev, V Papavassiliou, I H Park, J S Park, S Park, S K Park, W J Park, S F Pate, M Patel, H Pei, J-C Peng, H Pereira, D V Perepelitsa, G D N Perera, D Yu Peressounko, J Perry, R Petti, C Pinkenburg, R Pinson, R P Pisani, M Proissl, M L Purschke, H Qu, J Rak, B J Ramson, I Ravinovich, K F Read, S Rembeczki, K Reygers, D Reynolds, V Riabov, Y Riabov, E Richardson, T Rinn, D Roach, G Roche, S D Rolnick, M Rosati, C A Rosen, S S E Rosendahl, Z Rowan, J G Rubin, P Ružička, B Sahlmueller, N Saito, T Sakaguchi, K Sakashita, H Sako, V Samsonov, S Sano, M Sarsour, S Sato, T Sato, S Sawada, B Schaefer, B K Schmoll, K Sedgwick, J Seele, R Seidl, A Sen, R Seto, P Sett, A Sexton, D Sharma, I Shein, T-A Shibata, K Shigaki, M Shimomura, K Shoji, P Shukla, A Sickles, C L Silva, D Silvermyr, C Silvestre, K S Sim, B K Singh, C P Singh, V Singh, M Slunečka, M Snowball, R A Soltz, W E Sondheim, S P Sorensen, I V Sourikova, P W Stankus, E Stenlund, M Stepanov, S P Stoll, T Sugitate, A Sukhanov, T Sumita, J Sun, J Sziklai, E M Takagui, A Taketani, R Tanabe, Y Tanaka, S Taneja, K Tanida, M J Tannenbaum, S Tarafdar, A Taranenko, H Themann, D Thomas, T L Thomas, R Tieulent, A Timilsina, T Todoroki, M Togawa, A Toia, L Tomášek, M Tomášek, H Torii, C L Towell, R Towell, R S Towell, I Tserruya, Y Tsuchimoto, C Vale, H Valle, H W van Hecke, E Vazquez-Zambrano, A Veicht, J Velkovska, R Vértesi, M Virius, V Vrba, E Vznuzdaev, X R Wang, D Watanabe, K Watanabe, Y Watanabe, Y S Watanabe, F Wei, R Wei, J Wessels, A S White, S N White, D Winter, C L Woody, R M Wright, M Wysocki, B Xia, L Xue, S Yalcin, Y L Yamaguchi, K Yamaura, R Yang, A Yanovich, J Ying, S Yokkaichi, J H Yoo, I Yoon, Z You, G R Young, I Younus, H Yu, I E Yushmanov, W A Zajc, A Zelenski, S Zhou, L Zou
Jet production rates are measured in p+p and d+Au collisions at sqrt[s_{NN}]=200  GeV recorded in 2008 with the PHENIX detector at the Relativistic Heavy Ion Collider. Jets are reconstructed using the R=0.3 anti-k_{t} algorithm from energy deposits in the electromagnetic calorimeter and charged tracks in multiwire proportional chambers, and the jet transverse momentum (p_{T}) spectra are corrected for the detector response. Spectra are reported for jets with 12<p_{T}<50  GeV/c, within a pseudorapidity acceptance of |η|<0...
March 25, 2016: Physical Review Letters
Byung B Lee, Andrew N Nicolaides, Kenneth Myers, Mark Meissner, Evi Kalodiki, Claudio Allegra, Pier L Antignani, Niels Bækgaard, Kirk Beach, Giovanni Belcaro, Stephen Black, Lena Blomgren, Eliete Bouskela, Massimo Cappelli, Joseph Caprini, Patrick Carpentier, Attilio Cavezzi, Sylvain Chastanet, Jan T Christenson, Demetris Christopoulos, Heather Clarke, Alun Davies, Marianne Demaeseneer, Bo Eklöf, Stefano Ermini, Fidel Fernández, Claude Franceschi, Antonios Gasparis, George Geroulakos, Gianesini Sergio, Athanasios Giannoukas, Peter Gloviczki, Ying Huang, Veronica Ibegbuna, Stavros K Kakkos, Robert Kistner, Tilo Kölbel, Ralph L Kurstjens, Nicos Labropoulos, James Laredo, Christopher R Lattimer, Marzia Lugli, Fedor Lurie, Oscar Maleti, Jovan Markovic, Erika Mendoza, Javier L Monedero, Gregory Moneta, Hayley Moore, Nick Morrison, Giovanni Mosti, Olle Nelzén, Alfred Obermayer, Tomohiro Ogawa, Kurosh Parsi, Hugo Partsch, Fausto Passariello, Michel L Perrin, Paul Pittaluga, Seshadri Raju, Stefano Ricci, Antonio Rosales, Angelo Scuderi, Carl E Slagsvold, Anders Thurin, Tomasz Urbanek, Andre M VAN Rij, Michael Vasquez, Cees H Wittens, Paolo Zamboni, Steven Zimmet, Santiago Z Ezpeleta
There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolved in the latter part of the 20th century have dominated investigation. They have greatly improved our understanding of the anatomical patterns of venous reflux and obstruction...
June 2016: International Angiology: a Journal of the International Union of Angiology
Kayla Miller, Suraj Dixit, Amy-Lee Bredlau, Alfred Moore, Emilie McKinnon, Ann-Marie Broome
AIM: Glioblastoma multiforme is a devastating disease with no curative options due to the difficulty in achieving sufficient quantities of effective chemotherapies into the tumor past the blood-brain barrier. Micelles loaded with temozolomide (TMZ) were designed to increase the delivery of this drug into the brain. MATERIALS & METHODS: pH-responsive micelles composed of distearoyl phosphoethanolamine-PEG-2000-amine and N-palmitoyl homocysteine were surface-functionalized with PDGF peptide and Dylight 680 fluorophore...
March 2016: Nanomedicine
Rebecca A Kennedy, Mark W Scerbo, Brittany L Anderson-Montoya, Lee A Belfore, Alfred Z Abuhamad, Stephen S Davis
Objective To determine whether a visual aid overlaid on fetal heart rate (FHR) tracings increases detection of critical signals relative to images with no visual aid. Study Design In an experimental study, 21 undergraduate students viewed 240 images of simulated FHR tracings twice, once with the visual aids and once without aids. Performance was examined for images containing three different types of FHR signals (early deceleration, late deceleration, and acceleration) and four different FHR signal-to-noise ratios corresponding to FHR variability types (absent, minimal, moderate, and marked) identified by the National Institute of Child Health and Human Development (2008)...
March 2016: American Journal of Perinatology Reports
Gabriel C Brooks, Byron K Lee, Rajni Rao, Feng Lin, Daniel P Morin, Steven L Zweibel, Alfred E Buxton, Mark J Pletcher, Eric Vittinghoff, Jeffrey E Olgin
BACKGROUND: Persistent severe left ventricular (LV) systolic dysfunction after myocardial infarction (MI) is associated with increased mortality and is a class I indication for implantation of a cardioverter-defibrillator. OBJECTIVES: This study developed models and assessed independent predictors of LV recovery to >35% and ≥50% after 90-day follow-up in patients presenting with acute MI and severe LV dysfunction. METHODS: Our multicenter prospective observational study enrolled participants with ejection fraction (EF) of ≤35% at the time of MI (n = 231)...
March 15, 2016: Journal of the American College of Cardiology
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