keyword
https://read.qxmd.com/read/38536822/immediate-postnatal-prediction-of-death-or-bronchopulmonary-dysplasia-among-very-preterm-and-very-low-birth-weight-infants-based-on-gradient-boosting-decision-trees-algorithm-a-nationwide-database-study-in-japan
#21
JOURNAL ARTICLE
Kota Yoneda, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe, Naoto Takahashi
INTRODUCTION: Bronchopulmonary dysplasia (BPD) poses a substantial global health burden. Individualized treatment strategies based on early prediction of the development of BPD can mitigate preterm birth complications; however, previously suggested predictive models lack early postnatal applicability. We aimed to develop predictive models for BPD and mortality based on immediate postnatal clinical data. METHODS: Clinical information on very preterm and very low birth weight infants born between 2008 and 2018 was extracted from a nationwide Japanese database...
2024: PloS One
https://read.qxmd.com/read/38536028/insights-on-obstetric-outcomes-in-pregnant-individuals-with-marfan-syndrome-evidence-from-the-national-inpatient-sample
#22
JOURNAL ARTICLE
Saeed Baradwan, Majed S Alshahrani, Khalid Khadawardi, Maha Tulbah, Osama Alomar, Abdullah Alyousef, Ibtihal A Bukhari, Ahmed Abu-Zaid
BACKGROUND: We investigated the potential association between Marfan Syndrome (MFS) and adverse obstetric outcomes using the National Inpatient Sample (NIS) database. METHODS: We utilized the International Classification of Diseases (ICD-10) system to identify relevant codes and extracted data from the NIS database covering the period 2016-2019. Descriptive statistics and χ2 tests were employed to summarize and compare baseline characteristics. Univariate and multivariate regression analyses (adjusted for age, race, hospital region, smoking status, and alcohol misuse) were conducted to evaluate association between MFS and adverse obstetric outcomes...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38536027/understanding-oocyte-ageing
#23
JOURNAL ARTICLE
Hayden A Homer
Females are born with a finite and non-renewable reservoir of oocytes, which therefore decline both in number and quality with advancing age. A striking characteristic of oocyte quality is that "ageing" effects manifest whilst women are in their thirties and are therefore still chronologically and physically young. Furthermore, this decline is unrelenting and not modifiable to any great extent by lifestyle or diet. Since oocyte quality is rate-limiting for pregnancy success, as the proportion of good-quality oocytes progressively deteriorate, the chance of successful pregnancy during each 6-12-month period also decreases, becoming exponential after 37 years...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38535513/suprapubic-and-transurethral-bladder-access-for-voiding-cystourethrography-in-pediatric-male-patients
#24
JOURNAL ARTICLE
Wiebke Schlötelburg, Clemens Benoit, Mandy Kasper, Bernhard Petritsch, Andreas Max Weng, Thorsten Alexander Bley, Simon Veldhoen
PURPOSE: To compare suprapubic access (SPA) and transurethral catheterization (TUC) in voiding cystourethrogram (VCUG). METHODS: Retrospective single-center evaluation of 311 VCUG performed in male patients under 12 years of age. Two study groups were built based on the bladder access method. TUC was performed in 213 patients, whereas 98 received SPA. The groups were compared regarding the procedural switch rate, the complication rate, radiation parameters, the amount of contrast media applied and the examination quality...
March 13, 2024: Pediatric Reports
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#25
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38534344/intrauterine-growth-restriction-need-to-improve-diagnostic-accuracy-and-evidence-for-a-key-role-of-oxidative-stress-in-neonatal-and-long-term-sequelae
#26
REVIEW
Eva Nüsken, Sarah Appel, Leon Saschin, Celien Kuiper-Makris, Laura Oberholz, Charlotte Schömig, Anne Tauscher, Jörg Dötsch, Angela Kribs, Miguel A Alejandre Alcazar, Kai-Dietrich Nüsken
Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the tenth percentile. IUGR can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnion, lack of growth in the interval, estimated weight below the third percentile) and can also be present in fetuses and neonates with weights above the tenth percentile...
March 13, 2024: Cells
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#27
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533463/association-between-maternal-stress-and-premature-milk-cortisol-milk-iga-and-infant-health-a-cohort-study
#28
JOURNAL ARTICLE
Casey B Rosen-Carole, Susan Greenman, Hongyue Wang, Sharvari Sonawane, Ravi Misra, Tom O'Connor, Kirsi Järvinen, Carl D'Angio, Bridget E Young
BACKGROUND: Maternal stress is pervasive in the neonatal intensive care unit (NICU). Maternal stress is associated with changes in human milk (HM) immunomodulatory agents, which may impact neonatal health. We sought to determine the association between maternal stress, HM immunoglobulin A (IgA) and cortisol, and to assess how these milk components correlate with infant immune and neurodevelopmental outcomes. We then compared how these associations persist over time. METHODS: The study design involved a cohort study of exclusively breastfeeding mothers and their singleton moderately preterm (28-34 weeks) infants admitted to the NICU...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38533296/retrospective-comparative-analysis-of-neonatal-mortality-and-morbidity-in-preterm-singleton-and-multiple-births-single-center-experience
#29
JOURNAL ARTICLE
Mohammad Alhasoon, Bader Alqahtani, Mohamad Alreefi, Abdulaziz Homedi, Ghadah Alnami, Saif Alsaif, Kamal Ali
Objective. To compare mortality and major neonatal morbidities between singleton preterm infants and preterm infants of multiple gestations born <33 weeks' gestation. Method. Case-control study of preterm multiples and singletons <33 weeks' born at King Abdul-Aziz Medical City Riyadh (KAMC-R) between January 2017 and December 2020. Out-born infants and infants with lethal congenital abnormalities were excluded from the study. Mortality and major neonatal morbidities including bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), sepsis and surgical necrotizing enterocolitis (NEC) were compared between preterm singletons and multiples...
2024: Global Pediatric Health
https://read.qxmd.com/read/38533181/silencing-circatxn1-in-aging-nucleus-pulposus-cell-alleviates-intervertebral-disc-degeneration-via-correcting-progerin-mislocalization
#30
JOURNAL ARTICLE
Chao Yu, Jing Zhao, Feng Cheng, Jiangjie Chen, Jinyang Chen, Haibin Xu, Kesi Shi, Kaishun Xia, Siwen Ding, Kanbin Wang, Ronghao Wang, Yazhou Chen, Yi Li, Hao Li, Qixin Chen, Xiaohua Yu, Fangwei Shao, Chengzhen Liang, Fangcai Li
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that a novel circATXN1 highly accumulates in aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, and inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous nuclear ribonucleoprotein A2B1-mediated splicing circularization, promotes progerin translocation from the cell nucleus to the cytoplasm and inhibits the expression of insulin-like growth factor 1 receptor (IGF-1R)...
2024: Research: a science partner journal
https://read.qxmd.com/read/38533131/progerin-inhibits-the-proliferation-and-migration-of-melanoma-cells-by-regulating-the-expression-of-paxillin
#31
JOURNAL ARTICLE
Weixian Liu, Xinxian Huang, Weizhao Luo, Xinguang Liu, Weichun Chen
OBJECTIVE: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality. This study aimed to elucidate the potential therapeutic role of progerin in melanoma. MATERIALS AND METHODS: We constructed the melanoma A375 cell line and M14 cell line with stable expression of progerin...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38532012/immunophenotypes-in-psychosis-is-it-a-premature-inflamm-aging-disorder
#32
REVIEW
Song Chen, Yunlong Tan, Li Tian
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of both innate and adaptive immune components in psychotic disorders such as schizophrenia. Nevertheless, researchers are facing dilemmas of discrepant findings of immunophenotypes both outside and inside the brains of psychotic patients, as discovered by recent meta-analyses. These discrepancies make interpretations and interrogations on their roles in psychosis remain vague and even controversial, regarding whether certain immune cells are more activated or less so, and whether they are causal or consequential, or beneficial or harmful for psychosis...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38531393/predictors-of-breastfeeding-among-women-admitted-with-severe-preeclampsia-before-34-weeks
#33
JOURNAL ARTICLE
Sara J Grundy, Carmen Maria Avram Santoli, Jacquelyn Dillon, Alice Darling, Gregory Ethan Zemtsov, Jennifer J Cate, Sarahn Wheeler, Sarah Dotters-Katz
BACKGROUND: Patients with severe preeclampsia(sPREX) face barriers to successful breastfeeding(BF), including an increased risk of maternal and newborn complications, prematurity, and low birth weight. Patients with early-onset sPREX (before 34 weeks' gestation) may be at even greater risk, yet there is little data available on factors associated with BF challenges in this population. OBJECTIVE(S): We describe rates of BF initiation at hospital discharge and BF continuation at postpartum visit, and identify factors associated with BF non-initiation and BF cessation among patients admitted with early onset sPREX...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38531323/large-neutral-amino-acids-moderate-the-effects-of-metabolic-syndrome-on-cognitive-performance-in-middle-aged-adults
#34
JOURNAL ARTICLE
Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Dietmar Fuchs, Hirofumi Tanaka, Andreana P Haley
Introduction Two large neutral amino acids (LNAA), tryptophan and tyrosine, are precursors to cerebral neurotransmitters and are involved in cognitive function. Higher levels of LNAA in young adults are associated with improved cognition, although these associations appear to reverse over time. Given that exposure to metabolic syndrome (MetS) may induce premature cognitive aging, the current project aims to fill the gap in the literature by examining the effect of LNAA on cognitive performance in midlife adults with metabolic risks...
March 26, 2024: Annals of Nutrition & Metabolism
https://read.qxmd.com/read/38530546/impact-of-left-ventricular-hypertrophy-on-frequency-and-complexity-of-ventricular-arrhythmia-among-hypertensive-egyptian-patients
#35
JOURNAL ARTICLE
Ahmed Mokhtar Abd El Azeem, Mohamed Ahmed Abd Elmoneim, Samir Morkos Rafla, Gehan Magdy Youssif
BACKGROUND: Left ventricular hypertrophy (LVH) is associated with an increased risk of ventricular arrhythmias and cardiovascular mortality. The study objective was to investigate the effect of LVH severity on the complexity and severity of ventricular arrhythmias among a subset of Egyptian hypertensive patients. RESULTS: The study cohort consisted of 60 hypertensive patients with LVH as diagnosed by echocardiography. Their mean age was (53.7 ± 12...
March 26, 2024: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/38529852/parenteral-nutrition-emulsion-inhibits-cyp3a4-in-an-ipsc-derived-liver-organoids-testing-platform
#36
JOURNAL ARTICLE
Sean P Harrison, Saphira F Baumgarten, Maria E Chollet, Benedicte Stavik, Anindita Bhattacharya, Runar Almaas, Gareth J Sullivan
OBJECTIVES: Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones. To optimize nutrition regimens, models are required to predict PNALD. METHODS: We have exploited induced pluripotent stem cell derived liver organoids to provide a testing platform for PNALD...
March 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38529500/sexually-dimorphic-renal-expression-of-klotho-is-directed-by-a-kidney-specific-distal-enhancer-responsive-to-hnf1b
#37
Jakub Jankowski, Hye Kyung Lee, Chengyu Liu, Julia Wilflingseder, Lothar Hennighausen
Transcription enhancers are genomic sequences regulating common and tissue-specific genes and their disruption can contribute to human disease development and progression. Klotho , a sexually dimorphic gene specifically expressed in kidney, is well-linked to kidney dysfunction and its deletion from the mouse genome leads to premature aging and death. However, the sexually dimorphic regulation of Klotho is not understood. Here, we characterize two candidate Klotho enhancers using H3K27ac epigenetic marks and transcription factor binding and investigate their functions, individually and combined, through CRISPR-Cas9 genome engineering...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38528568/an-epidemiological-investigation-of-high-risk-infants-for-respiratory-syncytial-virus-infections-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Michela Servadio, Marco Finocchietti, Chiara Vassallo, Riccardo Cipelli, Franca Heiman, Giulia Di Lucchio, Bianca Oresta, Antonio Addis, Valeria Belleudi
BACKGROUND: Respiratory Syncytial Virus (RSV) infections may lead to severe consequences in infants born preterm with breathing problems (such as bronchopulmonary dysplasia (BPD) and respiratory distress syndrome (RDS)) or congenital heart diseases (CHD). Since studies investigating the influence of different gestational age (WGA) and concomitant specific comorbidities on the burden of RSV infections are scarce, the present study aimed to better characterize these high-risk populations in the Italian context...
March 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38528508/triglyceride-glucose-index-in-early-pregnancy-predicts-the-risk-of-gestational-diabetes-a-prospective-cohort-study
#39
JOURNAL ARTICLE
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
OBJECTIVE: This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary objectives were to evaluate the predictive potential of the TyG index for GDM, determine the optimal threshold value of the TyG index for GDM assessment, and compare the predictive performance of the TyG index alone versus its combination with maternal age and pre-pregnancy body mass index on GDM...
March 25, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38527850/disruption-of-thyroid-hormone-receptor-thrab-leads-to-female-infertility-in-zebrafish
#40
JOURNAL ARTICLE
Nana Ai, Cho Rong Han, Hui Zhao, Sheue-Yann Cheng, Wei Ge
Thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are vital for development, growth, and metabolism. Thyroid dysfunction can also cause problems in fertility, suggesting involvement of THs in reproduction. In zebrafish, there exist two forms of TH receptor alpha gene (THRα: thraa and thrab). Disruption of these genes by CRISPR/Cas9 showed no reproductive irregularities in thraa mutant; however, inactivation of thrab gene resulted in female infertility. Although young female mutants (thrabm/m) showed normal ovarian development and folliculogenesis before sexual maturation, they failed to release eggs during oviposition after sexual maturation...
March 25, 2024: Endocrinology
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