keyword
MENU ▼
Read by QxMD icon Read
search

premature ageing

keyword
https://www.readbyqxmd.com/read/28102853/skin-to-skin-contact-after-birth-and-the-natural-course-of-neurosteroid-levels-in-healthy-term-newborns
#1
K R McCallie, N W Gaikwad, M E Castillo Cuadrado, M Aleman, J E Madigan, D K Stevenson, V K Bhutani
OBJECTIVE: To determine the postnatal course of neurosteroid levels in relation to gender, mode of delivery and the extent of skin-to-skin (STS) contact during the first days of life in healthy term newborns. STUDY DESIGN: Prospective observational study of 39 neonates in which parents recorded total duration of STS in the first 2 days and nine neurosteroids (dehydroepiandrosterone-sulfate, progesterone, pregnenolone, pregnenolone-sulfate, allopregnanolone, isopregnanolone, epipregnanolone, pregnanolone and pregnanolone-sulfate) were assayed from blood samples at birth and at 1-2 days of age...
January 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28102546/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#2
REVIEW
Aisha A Aslam, Colin Higgins, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis is a common life-shortening genetic disorder in the Caucasian population (less common in other ethnic groups) caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces and the mutation most notably affects the airways. In the lungs of people with cystic fibrosis, defective protein results in a dehydrated surface liquid and compromised mucociliary clearance...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28101907/increased-arf-p53-activity-in-stem-cells-aging-and-cancer
#3
REVIEW
Estefania Carrasco-Garcia, Manuel Moreno, Leire Moreno-Cugnon, Ander Matheu
Arf/p53 pathway protects the cells against DNA damage induced by acute stress. This characteristic is the responsible for its tumor suppressor activity. Moreover, it regulates the chronic type of stress associated with aging. This is the basis of its anti-aging activity. Indeed, increased gene dosage of Arf/p53 displays elongated longevity and delayed aging. At a cellular level, it has been recently shown that increased dosage of Arf/p53 delays age-associated stem cell exhaustion and the subsequent decline in tissue homeostasis and regeneration...
January 19, 2017: Aging Cell
https://www.readbyqxmd.com/read/28101838/renal-consequences-of-preterm-birth
#4
REVIEW
Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch, Abhay Lodha
BACKGROUND: The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viability in premature infants have been pushed to lower gestational ages, the long-term impact of prematurity on kidneys still remains a significant burden during hospital stay and beyond. OBJECTIVES: The purpose of this study is to summarize available evidence, mechanisms, and short- and long-term renal consequences of prematurity and identify nephroprotective strategies and areas of uncertainty...
December 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/28101199/ultrastructural-changes-during-lung-carcinogenesis-modulation-by-curcumin-and-quercetin
#5
Xin Wang, Lei Wang, Hao Zhang, Ke Li, Jiqin You
The aim of the present study was to examine the effectiveness of curcumin and quercetin in modulating ultrastructural changes during lung carcinogenesis. A total of 24 male laka mice were divided into the normal control, benzo[a]pyrene (BP)-treated, BP+curcumin-treated, BP+quercetin- treated, and BP+curcumin+quercetin-treated groups (n=6 per group). Lung carcinogenesis was induced by a single intraperitoneal injection of BP [100 mg/kg of body weight (b.wt.)]. Curcumin was supplemented to mice at a dose level of 60 mg/kg of b...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100483/electrophysiological-changes-in-12-year-old-children-born-mlp-reduced-vep-amplitude-in-mlp-children
#6
Lina H Raffa, Josefin Nilsson, Jovanna Dahlgren, Marita Andersson Grönlund
AIM: To study the electrophysiological changes in relation to fundus morphology in moderate-to-late preterm (MLP) children with no previous history of retinopathy of prematurity. METHODS: Visual acuity (VA), refraction and fundus variables measured by optical coherence tomography, pattern reversal visual evoked potentials and full-field electroretinography (ff-ERG) were obtained from 22 twelve-year-old MLP children (11 male, 11 female) and 21 full-term controls...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28099980/challenges-faced-in-translating-the-benefits-of-surfactant-replacement-therapy-to-a-resource-limited-setting
#7
N Hamilton, Helen Trotman
Aim To determine the challenges, if any, in translating the benefits of surfactant replacement therapy (SRT) to a resource-limited setting. Method This was a retrospective descriptive study comparing the outcome of 75 cases who received surfactant and 69 controls who did not at the University Hospital of the West Indies during the period 2001 to 2011. Descriptive analyses were performed. Statistical significance was taken at the level p < 0.05. Results Only 13% of neonates with respiratory distress syndrome received surfactant therapy...
January 18, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28099974/temporary-vacuum-assisted-closure-of-the-open-abdomen-in-neonates
#8
Kengo Hattori, Alp Numanoglu, Sharon Cox
Introduction The need for open abdomen in the treatment of severely ill neonates will increase in time as more complex abdominal procedures are undertaken. However, the experience of temporary closure of an open abdomen using vacuum-assisted closure (VAC) system is still relatively limited in premature and term neonates. The aim of this study is to describe and review our experience in the use of temporary VAC of the open abdomen for neonates with varying pathological processes. Materials and Methods A retrospective folder review of all neonates treated with VAC for open abdomen over the study period of 2010 to 2014 at our institution was performed...
January 18, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28098735/optical-coherence-tomography-angiography-of-the-fovea-in-children-born-preterm
#9
Khalil Ghasemi Falavarjani, Nicholas A Iafe, Federico G Velez, Steven D Schwartz, Srinivas R Sadda, David Sarraf, Irena Tsui
PURPOSE: To compare the foveal avascular zone (FAZ) area measured by optical coherence tomography angiography in children who had been born preterm with age-matched controls. METHODS: In this cross-sectional observational comparative case series, 43 eyes of 26 children (28 eyes of 15 former preterm infants and 15 eyes of 11 former term infants) between the ages of 4 and 12 years old were included. Optical coherence tomography angiography with a scan size of 3 × 3 was performed for all eyes...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098724/central-macular-thickness-in-6-5-year-old-children-born-extremely-preterm-is-strongly-associated-with-gestational-age-even-when-adjusted-for-risk-factors
#10
Anna E C Molnar, Rebecka M Rosén, Maria Nilsson, Eva K B Larsson, Gerd E Holmström, Kerstin M Hellgren
PURPOSE: To assess the macular thickness in 6.5-year-old children born extremely preterm (EPT) in comparison with children born at term and to investigate risk factors associated with the macular thickness in the preterm group. METHODS: A population-based study of 6.5-year-old children born before the gestational age of 27 weeks and age-matched control subjects. Macular assessments with optical coherence tomography were performed, and the results were compared with neonatal risk factors and sex...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098488/pulse-wave-velocity-and-myocardial-performance-index-in-premature-ovarian-insufficiency
#11
Muhammed Necati Murat Aksoy, Nermin Akdemir, Harun Kilic, Sabiye Yilmaz, Ramazan Akdemir, Huseyin Gunduz
OBJECTIVE: Epidemiological studies suggest that women with loss of ovarian function at early ages may be especially burdened by cardiovascular disease (CVD). In this study, we aimed to evaluate pulse wave velocity and myocardial performance index in patients with premature ovarian insufficiency (POI). DESIGN: We enrolled 51 female patients (mean age 38.9 ± 6.7 years) with POI and 49 healthy subjects (mean age 36.8 ± 5.2 years). All participants underwent a detailed echocardiographic examination and pulse wave velocity (PWV) measurement which is basically the velocity of pulse wave travelling from carotid to femoral artery...
January 18, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28097840/assessment-of-lipid-profile-and-some-risk-factors-of-atherosclerosis-in-children-whose-parents-had-early-onset-coronary-artery-disease
#12
Helen Bornaun, Naci Öner, Kemal Nişli, Kazım Öztarhan, Taner Yavuz, Ümit Türkoğlu, Aygün Dindar, Rukiye Eker Ömeroglu
BACKGROUND/AIM: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). POPULATION AND METHODS: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28096374/phylogenetic-analysis-of-the-human-antibody-repertoire-reveals-quantitative-signatures-of-immune-senescence-and-aging
#13
Charles F A de Bourcy, Cesar J Lopez Angel, Christopher Vollmers, Cornelia L Dekker, Mark M Davis, Stephen R Quake
The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and elderly individuals before and after influenza vaccination. We determined that BCR repertoires become increasingly specialized over a span of decades, but less plastic...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096041/advance-care-planning-in-adults-with-congenital-heart-disease-a-patient-priority
#14
Lisa X Deng, Lacey P Gleason, Abigail M Khan, David Drajpuch, Stephanie Fuller, Leah A Goldberg, Christopher E Mascio, Sara L Partington, Lynda Tobin, Yuli Y Kim, Adrienne H Kovacs
BACKGROUND: Adult congenital heart disease (ACHD) patients with moderate or great defect complexity are at risk for premature death. Although early engagement in advance care planning (ACP) is recommended, previous research suggests that it seldom occurs. METHODS: This study investigated ACHD patient preferences for ACP and factors that impact preferences. ACHD patients completed an ACP preferences questionnaire, the Hospital Anxiety and Depression Scale and a measure of attachment styles...
January 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28095501/birth-weight-and-its-relationship-with-the-cardiac-autonomic-balance-in-healthy-children
#15
Livia Victorino Souza, Vanessa Oliveira, Franciele De Meneck, Ana Paula Grotti Clemente, Maria Wany Louzada Strufaldi, Maria do Carmo Franco
Several studies indicate that the fetal environment plays a significant role in the development of cardiometabolic disease later in life. However, a few studies present conflicting data about the correlation between birth weight and the impairment of cardiac autonomic modulation. The purpose of the present study was to provide further knowledge to elucidate this contradictory relationship. One hundred children aged 5 and 14 years had anthropometric parameters, body composition and blood pressure levels determined...
2017: PloS One
https://www.readbyqxmd.com/read/28095477/the-burden-of-mental-disorders-in-the-eastern-mediterranean-region-1990-2013
#16
Raghid Charara, Mohammad Forouzanfar, Mohsen Naghavi, Maziar Moradi-Lakeh, Ashkan Afshin, Theo Vos, Farah Daoud, Haidong Wang, Charbel El Bcheraoui, Ibrahim Khalil, Randah R Hamadeh, Ardeshir Khosravi, Vafa Rahimi-Movaghar, Yousef Khader, Nawal Al-Hamad, Carla Makhlouf Obermeyer, Anwar Rafay, Rana Asghar, Saleem M Rana, Amira Shaheen, Niveen M E Abu-Rmeileh, Abdullatif Husseini, Laith J Abu-Raddad, Tawfik Khoja, Zulfa A Al Rayess, Fadia S AlBuhairan, Mohamed Hsairi, Mahmoud A Alomari, Raghib Ali, Gholamreza Roshandel, Abdullah Sulieman Terkawi, Samer Hamidi, Amany H Refaat, Ronny Westerman, Aliasghar Ahmad Kiadaliri, Ali S Akanda, Syed Danish Ali, Umar Bacha, Alaa Badawi, Shahrzad Bazargan-Hejazi, Imad A D Faghmous, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Jost B Jonas, Barthelemy Kuate Defo, Alem Mehari, Saad B Omer, Farshad Pourmalek, Olalekan A Uthman, Ali A Mokdad, Fadi T Maalouf, Foad Abd-Allah, Nadia Akseer, Dinesh Arya, Rohan Borschmann, Alexandra Brazinova, Traolach S Brugha, Ferrán Catalá-López, Louisa Degenhardt, Alize Ferrari, Josep Maria Haro, Masako Horino, John C Hornberger, Hsiang Huang, Christian Kieling, Daniel Kim, Yunjin Kim, Ann Kristin Knudsen, Philip B Mitchell, George Patton, Rajesh Sagar, Maheswar Satpathy, Kim Savuon, Soraya Seedat, Ivy Shiue, Jens Christoffer Skogen, Dan J Stein, Karen M Tabb, Harvey A Whiteford, Paul Yip, Naohiro Yonemoto, Christopher J L Murray, Ali H Mokdad
The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of life lost-YLLs) and nonfatal outcomes (years lived with disability-YLDs). DALYs are computed by adding YLLs and YLDs for each age-sex-country group...
2017: PloS One
https://www.readbyqxmd.com/read/28095451/comparing-human-metapneumovirus-and-respiratory-syncytial-virus-viral-co-detections-genotypes-and-risk-factors-for-severe-disease
#17
Nina Moe, Sidsel Krokstad, Inger Heimdal Stenseng, Andreas Christensen, Lars Høsøien Skanke, Kari Ravndal Risnes, Svein Arne Nordbø, Henrik Døllner
BACKGROUND: It is unclarified as to whether viral co-detection and human metapneumovirus (HMPV) genotypes relate to clinical manifestations in children with HMPV and lower respiratory tract infection (LRTI), and if the clinical course and risk factors for severe LRTI differ between HMPV and respiratory syncytial virus (RSV). METHODS: We prospectively enrolled hospitalized children aged <16 years with LRTI from 2006 to 2015. Children were clinically examined, and nasopharyngeal aspirates were analyzed using semi-quantitative, real-time polymerase chain reaction tests for HMPV, RSV and 17 other pathogens...
2017: PloS One
https://www.readbyqxmd.com/read/28093873/diagnostic-and-management-challenges-from-childhood-puberty-through-to-transition-in-severe-insulin-resistance-due-to-insulin-receptor-mutations
#18
Christina Wei, Christine P Burren
Two Caucasian girls, both of normal weight and body mass indices, were diagnosed with type A insulin resistance (IR) in childhood. Case 1 presented with premature adrenarche aged 7 years, then by age 12 years had hirsutism, acne, acanthosis nigricans, and asymptomatic diabetes. Subsequent investigation revealed raised adiponectin (15.3 mg/L) and heterozygous p.Pro1205Leu mutation in the INSR gene encoding the insulin receptor. She experienced postprandial hypoglycaemia on metformin; acarbose was trialled and discontinued aged 16 years, as she became normoglycaemic...
January 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28093682/association-between-ischemic-heart-disease-and-systemic-lupus-erythematosus-a-large-case-control-study
#19
Abdulla Watad, Arsalan Abu Much, Danielle Bracco, Naim Mahroum, Doron Comaneshter, Arnon D Cohen, Howard Amital
Ischemic heart disease (IHD) is a well identified cause of mortality in systemic lupus erythematosus (SLE) patients due to an accelerated premature atherosclerosis. We investigated the proportion of comorbid IHD among SLE patients derived from a large, national real-life database. Using data from the largest HMO in Israel, the Clalit Health Services, we selected for patients with SLE. These patients were compared with age and sex matched controls with regards to the proportion of IHD in a case-control study...
January 17, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28093442/rococo-study-a-real-world-evaluation-of-an-over-the-counter-medicine-in-acute-cough-a-multicentre-randomised-controlled-study
#20
S S Birring, J Brew, A Kilbourn, V Edwards, R Wilson, A H Morice
OBJECTIVES: To investigate the efficacy and safety of CS1002, an over-the-counter cough treatment containing diphenhydramine, ammonium chloride and levomenthol in a cocoa-based demulcent. DESIGN: A multicentre, randomised, parallel group, controlled, single-blinded study in participants with acute upper respiratory tract infection-associated cough. SETTING: 4 general practitioner (GP) surgeries and 14 pharmacies in the UK. PARTICIPANTS: Participants aged ≥18 years who self-referred to a GP or pharmacist with acute cough of <7 days' duration...
January 16, 2017: BMJ Open
keyword
keyword
104940
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"