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https://www.readbyqxmd.com/read/29045961/-effects-of-recent-upper-respiratory-tract-infections-on-incidence-of-the-perioperative-respiratory-adverse-events-in-children-a-prospective-cohort-study
#1
C Q Li, D X Wang, T Cheng, X Y Zheng
OBJECTIVE: To investigate the effects of the recent upper respiratory tract infections (URI) on the incidence of perioperative respiratory adverse events in children scheduled to undergo general anesthesia and elective surgery. METHODS: In the study, 232 children undergoing general anesthesia with laryngeal mask airway (LMA) for elective ophthalmic surgeries at Peking University First Hospital, Beijing, China, from Nov. 1, 2015 to May 10, 2016 were enrolled. On the day of the surgery, the parents of the children were preoperatively asked to fill out a questionnaire regarding the baseline characteristics and medical history of the children, including gender, age, height, weight, history of URI within the last 2 weeks before anesthesia, history of premature, long-term passive smoking exposure, habitual sleep snoring, and history of asthma...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045642/patient-and-tumor-characteristics-and-their-influence-on-early-therapy-persistence-with-letrozole-in-postmenopausal-patients-with-early-breast-cancer
#2
N Nabieva, S Kellner, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, N Fersis, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C Rauh, C M Bayer, A Jacob, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
Background: Patients' compliance and persistence with endocrine treatment has a significant effect on the prognosis in early breast cancer (EBC). The purpose of this analysis was to identify possible reasons for non-persistence, defined as premature cessation of therapy, on the basis of patient and tumor characteristics in individuals receiving adjuvant treatment with letrozole. Patients and methods: The EvAluate-TM Study is a prospective, multicenter, noninterventional study in which treatment with the aromatase inhibitor letrozole was evaluated in postmenopausal women with hormone receptor-positive EBC in the early therapy phase...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#3
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 17, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29045045/mesenchymal-stromal-cell-therapy-in-bronchopulmonary-dysplasia-systematic-review-and-meta-analysis-of-preclinical-studies
#4
Sajit Augustine, Marc T Avey, Brittany Harrison, Tiffany Locke, Mona Ghannad, David Moher, Bernard Thébaud
Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM)...
October 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29044351/surgical-management-of-necrotizing-enterocolitis-in-an-incredibly-low-birth-weight-infant-and-review-of-the-literature
#5
A Zangari, C Noviello, S Nobili, G Cobellis, C Gulia, R Piergentili, S Gigli, V Carnielli
Survival of preterm infants have dramatically improved over the last decades. Nonetheless, infants born preterm remain vulnerable to many complications, including necrotizing enterocolitis (NEC). The severity of the disease and the mortality rate are directly correlated with decreasing gestational age and birth weight. Despite surgical treatment mortality rate remains very high in extremely premature infants, especially in newborns at the lowest limit of viability. Survival of infants of birth weight (BW) below 750 g has been increasingly reported in recent years, however the overall mortality in extremely low "BW" infants (ELBW) requiring surgery for NEC has not decreased over the past years...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29044036/-five-decades-of-coronary-artery-disease-in-iceland-data-from-the-icelandic-heart-association
#6
Karl Andersen, Thor Aspelund, Elías Freyr Gudmundsson, Kristin Siggeirsdottir, Rosa Bjork Thorolfsdottir, Gunnar Sigurdsson, Vilmundur Gudnason
Coronary artery disease has been the leading cause of death and disability in Iceland during the past decades although in recent years, malignancy has taken over that position. A steady improvement in the level of major risk factors has been evident since 1980. This trend explains 72% of the decrease in premature mortality from coronary artery disease during the past three decades. However, an opposing trend in increasing obesity and type 2 diabetes has attenuated this decline in premature deaths. Unchanged risk factor trends will lead to increasing cardiovascular mortality in the years to come...
October 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29043919/beyond-survival-5-year-neurodevelopmental-follow-up-of-a-cohort-of-preterm-infants-in-colombo-sri-lanka
#7
S P Sumanasena, D V Vipulaguna, M M Mendis, N S Gunawardena
BACKGROUND: There is a lack of information on long-term neurodevelopmental outcome in preterm neonates in low- and middle-income countries. OBJECTIVES: To describe the developmental attainments of preterm neonates followed up for 5 years and to identify the risk factors for impairment. METHOD: A prospective descriptive cohort study was undertaken in neonates of 34 weeks gestation born within a period of 12 months at a single tertiary maternity and neonatal unit in Colombo, Sri Lanka...
October 18, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29043398/oral-paracetamol-for-patent-ductus-arteriosus-rescue-closure
#8
Pramod Pharande, Hadley Watson, Kenneth Tan, Arvind Sehgal
The objective of this study was to ascertain the efficacy of oral paracetamol in closing a symptomatic patent ductus arteriosus (PDA) when used as 'rescue' option. After obtaining ethics approval, a retrospective appraisal of the data from April 2014 to July 2015 was performed. Infants who were administered oral paracetamol either after unsuccessful therapy with ibuprofen or where it was considered contraindicated were included. A previously published echocardiographic scoring schema to stratify for ductal disease severity was used...
October 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29043097/histological-study-on-the-effect-of-nicotine-on-adult-male-guinea-pig-thin-skin
#9
Sohair A Eltony, Safaa S Ali
Tobacco smoking has been identified as an important factor in premature skin aging to detect the histological changes occurred in adult male guinea pig thin skin under the influence of low and high doses of nicotine; which constitutes approximately 0.6%-3.0% of the dry weight of tobacco. Fifteen adult male pigmented guinea pigs were equally divided into three groups: group I, control; group IIA, low dose nicotine treated; 3 mg/kg subcutaneously for 4 weeks; and group IIB, high dose nicotine treated; 6 mg/kg subcutaneously for 4 weeks...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042930/relevance-of-clinical-features-in-the-prognosis-of-bronchopulmonary-dysplasia-in-premature-infants
#10
Zhifang Du, Xiangyong Kong, Yanli Ren, Zhichun Feng, Junjin Huang, Jia Chen, Ruijuan Wang
The aim of this study is to determine the accuracy rate of bronchopulmonary dysplasia (BPD) diagnosis and risk factors of short-term poor prognosis for premature infants. This study analyzed the clinical data of 81 premature infants (<32 weeks gestational age) with BPD, who were on oxygen therapy >28 days, and survived >36 weeks (corrected age). Outcome measures included treatments, conditions on the 28th day after birth, oxygen therapy conditions at the 36th week, occurrence of any serious complications during hospital stay...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042866/effects-of-cord-blood-vitamin-d-levels-on-the-risk-of-neonatal-sepsis-in-premature-infants
#11
Birgul Say, Nurdan Uras, Suzan Sahin, Halil Degirmencioglu, Serife Suna Oguz, Fuat Emre Canpolat
PURPOSE: Vitamin D plays a key role in immune function. Vitamin D deficiency may play a role in the pathogenesis of infections, and low levels of circulating vitamin D are strongly associated with infectious diseases. In this study, we aimed to evaluate the effects of low vitamin D levels in cord blood on neonatal sepsis in preterm infants. METHODS: One hundred seventeen premature infants with gestational age of <37 weeks were enrolled. In the present study, severe vitamin D deficiency (group 1) was defined as a 25-hydroxyvitamin D (25(OH)D) concentration <5 ng/mL; vitamin D insufficiency (group 2), 25(OH)D concentration ≥5 ng/mL and <15 ng/mL; and vitamin D sufficiency (group 3), 25(OH)D concentration ≥15 ng/mL...
August 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29041825/cathepsin-l-deficiency-results-in-reactive-oxygen-species-ros-accumulation-and-vascular-cells-activation
#12
Guo-Xiang Fu, Alex F Chen, Qiu-Mei Xu, Bei-Bei Han, Gao-Zhong Huang, Yuan Zhong
Recent evidence suggests a link between cathepsin L (CTSL) and vascular diseases. However, its contribution to reactive oxygen species (ROS) homeostasis in the vasculature remains unknown. p66shc is a redox enzyme implicated in mitochondrial ROS generation and translation of oxidative signals. In this study, we explored the relationship between CTSL and oxidative damage in vasculature and whether the oxidative damage is mediated by p66shc.Carotid arteries from aged mice (24 months old) showed a reduction in CTSL expression compared with young wild-type mice (4 months old)...
October 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29040877/corpus-luteum-dynamics-after-ovulation-induction-with-or-without-previous-exposure-to-progesterone-in-prepubertal-nellore-heifers
#13
Dayane Priscila Vrisman, Natália Marins Bastos, Guilherme Fazan Rossi, Naiara Nantes Rodrigues, Luisa Pucci Bueno Borges, Augusto Ryonosuke Taira, Cláudia Cristina Paro de Paz, Guilherme de Paula Nogueira, Pedro Paulo Maia Teixeira, Fábio Morato Monteiro, Maria Emília Franco Oliveira
The objectives of this study were 1) to monitor corpus luteum (CL) dynamics after two different protocols of ovulation induction in prepubertal Nellore heifers, and 2) to determine differences in luteal function. Fifty-seven heifers (weight 289.61 ± 32.28 kg, BCS 5.66 ± 0.65, age 17.47 ± 0.81 months) were divided into two groups: GP4+GnRH received a progesterone (P4) device of 3rd use for 10 days, followed by the administration of 0.02 mg buserelin acetate (GnRH) 48 h after removal of the device, and GGnRH received only GnRH...
October 13, 2017: Theriogenology
https://www.readbyqxmd.com/read/29040557/divergence-and-convergence-in-cause-specific-premature-adult-mortality-in-mexico-and-us-mexican-hispanics-from-1995-to-2015-analyses-of-4-9-million-individual-deaths
#14
Luz Myriam Reynales-Shigematsu, Carlos Manuel Guerrero-López, Mauricio Hernández Ávila, Hyacinth Irving, Prabhat Jha
Background: Mexicans and US Mexican Hispanics share modifiable determinants of premature mortality. We compared trends in mortality at ages 30-69 in Mexico and among US Mexican Hispanics from 1995 to 2015. Methods: We examined nationally representative statistics on 4.2 million Mexican and 0.7 million US deaths to examine cause-specific mortality. We used lung cancer indexed methods to estimate smoking-attributable deaths stratified by high and lower burden Mexican states...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29039624/factors-associated-with-cessation-of-smoking-among-swiss-adults-between-1991-and-2011-results-from-the-sapaldia-cohort
#15
Diana Ayala-Bernal, Nicole Probst-Hensch, Thierry Rochat, Robert Bettschart, Otto Brändli, Pierre-Olivier Bridevaux, Luc Burdet, Martin Frey, Margaret Gerbase, Marco Pons, Thomas Rothe, Daiana Stolz, Jean-Marie Tschopp, Alexander Turk, Nino Künzli, Christian Schindler
INTRODUCTION: Smoking is still the most preventable cause of disease and premature death in Switzerland, as elsewhere. We aimed to assess the main determinants of smoking cessation in the population-based cohort of SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). METHODS: The SAPALDIA study was initiated in 1991 with 9651 participants aged 18 to 60 years from eight areas (S1). Follow-up assessments were conducted in 2002 (S2; 8047 participants) and 2010/11 (S3; 6088 participants)...
October 17, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29039551/upregulation-of-rho7-in-the-temporal-lobe-tissue-of-humans-with-intractable-epilepsy
#16
Xinglong Yang, Baiyuan Yang, Haonan Li, Hui Ren
Patients with intractable epilepsy (IE) exhibit an increased risk of premature death, psychosocial dysfunction and decreasing quality of life. The present study aimed to investigate the alteration in the expression of Rho7 in brain tissue from patients with IE, and to examine the association between Rho7 protein expression and IE. Temporal lobe samples were collected from the temporal lobes of 33 patients with IE patients and 10 age‑ and gender‑matched histologically healthy controls. Immunohistochemical staining was conducted to assess the number of Rho7‑positive cells...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039043/layer-dependent-role-of-collagen-recruitment-during-loading-of-the-rat-bladder-wall
#17
Fangzhou Cheng, Lori A Birder, F Aura Kullmann, Jack Hornsby, Paul N Watton, Simon Watkins, Mark Thompson, Anne M Robertson
In this work, we re-evaluated long-standing conjectures as to the source of the exceptionally large compliance of the bladder wall. Whereas these conjectures were based on indirect measures of loading mechanisms, in this work we take advantage of advances in bioimaging to directly assess collagen fibers and wall architecture during biaxial loading. A custom biaxial mechanical testing system compatible with multiphoton microscopy was used to directly measure the layer-dependent collagen fiber recruitment in bladder tissue from 9 male Fischer rats (4 adult and 5 aged)...
October 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29038823/left-ventricular-twist-in-hypertrophic-cardiomyopathy-predictor-of-nonsustained-ventricular-tachycardia
#18
O Candan, C Gecmen, A Kalaycı, E Bayam, A Guner, S Gunduz, S Cersit, M Ozkan
BACKGROUND: We investigated the efficacy of clinical and classic echocardiographic parameters in predicting the occurrence of nonsustained ventricular tachycardia (NsVT) in patients with hypertrophic cardiomyopathy (HCM). METHODS: The study comprised 59 patients with HCM (47 male, [80%]; mean age, 48.48 ± 14.16 years). Clinical, electrocardiographic, as well as classic two-dimensional and speckle-tracking echocardiography (STE) data were collected. All patients had Holter monitoring within 24-72 h of the echocardiographic examination...
October 16, 2017: Herz
https://www.readbyqxmd.com/read/29038314/physical-activity-reduces-risk-of-premature-mortality-in-patients-with-type-1-diabetes-with-and-without-kidney-disease
#19
Heidi Tikkanen-Dolenc, Johan Wadén, Carol Forsblom, Valma Harjutsalo, Lena M Thorn, Markku Saraheimo, Nina Elonen, Heikki O Tikkanen, Per-Henrik Groop
OBJECTIVE: The aims of the study were to assess how baseline leisure-time physical activity (LTPA) and its exercise components intensity, duration, and frequency are associated with all-cause and cardiovascular mortality in patients with type 1 diabetes 1) overall, 2) stratified by presence or absence of chronic kidney disease (CKD), and 3) stratified by sex. RESEARCH DESIGN AND METHODS: The study design was prospective and observational and included 2,639 patients with type 1 diabetes from the ongoing nationwide multicenter Finnish Diabetic Nephropathy (FinnDiane) Study...
October 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29038202/brain-regional-blood-flow-and-working-memory-performance-predict-change-in-blood-pressure-over-2-years
#20
J Richard Jennings, Alicia F Heim, Lei K Sheu, Matthew F Muldoon, Christopher Ryan, H Michael Gach, Claudiu Schirda, Peter J Gianaros
Hypertension is a presumptive risk factor for premature cognitive decline. However, lowering blood pressure (BP) does not uniformly reverse cognitive decline, suggesting that high BP per se may not cause cognitive decline. We hypothesized that essential hypertension has initial effects on the brain that, over time, manifest as cognitive dysfunction in conjunction with both brain vascular abnormalities and systemic BP elevation. Accordingly, we tested whether neuropsychological function and brain blood flow responses to cognitive challenges among prehypertensive individuals would predict subsequent progression of BP...
October 16, 2017: Hypertension
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