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hypersplenism review

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https://www.readbyqxmd.com/read/27906797/non-cirrhotic-portal-fibrosis-in-pediatric-population
#1
Vikrant Sood, Bikrant Bihari Lal, Rajeev Khanna, Dinesh Rawat, Chhagan Bihari Sharma, Seema Alam
BACKGROUND: Non-cirrhotic portal fibrosis (NCPF) has been classically described as a disease of young to middle age with limited literature regarding its occurrence, onset or clinical presentation in children. We hereby present a series of 19 patients diagnosed and managed as NCPF in pediatric age group. METHODS: A retrospective review of all the patients presenting to the pediatric hepatology department (age < 18 years) and diagnosed as NCPF was done and data was evaluated...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27896406/evaluation-of-rex-shunt-on-cavernous-transformation-of-the-portal-vein-in-children
#2
Ruo-Yi Wang, Jun-Feng Wang, Xiao-Gang Sun, Qian Liu, Jia-Long Xu, Qi-Gang Lv, Wei-Xiu Chen, Jin-Liang Li
BACKGROUND: Children with cavernous transformation of the portal vein (CTPV) develop severe complications from prehepatic portal hypertension, such as recurrent variceal bleeding and thrombocytopenia. In this study, we reported the results of 30 children with symptomatic CTPV that were treated by a Rex shunt. The effectiveness of this surgical approach was evaluated. METHODS: A retrospective review was performed of 30 children aged between 3 and 18 years with CTPV, who underwent a Rex shunt between 2008 and 2015...
November 28, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27720430/the-role-of-splenectomy-before-liver-transplantation-in-biliary-atresia-patients
#3
Yoshiaki Takahashi, Toshiharu Matsuura, Yusuke Yanagi, Koichiro Yoshimaru, Tomoaki Taguchi
BACKGROUND/PURPOSE: There is currently no unified view regarding whether liver transplantation or splenectomy should be performed for hypersplenism before liver transplantation in biliary atresia (BA) patients. We herein describe the efficacy of splenectomy before liver transplantation. METHODS: Splenectomy was performed in ten patients with hypersplenism associated with BA. We retrospectively reviewed their perioperative and postoperative courses, the number of leukocytes and thrombocytes, and the MELD score...
September 26, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27703501/hypersplenism-history-and-current-status
#4
Yunfu Lv, Wan Yee Lau, Yejuan Li, Jie Deng, Xiaoyu Han, Xiaoguang Gong, Ning Liu, Hongfei Wu
Hypersplenism is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells. This review summarizes the history of hypersplenism, discuss its classification and pathogenesis, and examines its diagnosis and treatment options. We performed a comprehensive literature search using PubMed, Web of Knowledge and the China National Knowledge Infrastructure (CNKI) database, reviewed hypersplenism-related articles and summarized the major findings. According to its etiological causes, hypersplenism is characterized by splenomegaly and peripheral cytopenias...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27465326/laparoscopic-versus-traditional-open-splenectomy-for-hepatocellular-carcinoma-with-hypersplenism
#5
Han-Hua Dong, Bin Mei, Fei-Long Liu, Zhi-Wei Zhang, Bi-Xiang Zhang, Zhi-Yong Huang, Xiao-Ping Chen, Wan-Guang Zhang
This study aimed to examine the efficacy of the laparoscopic vs. traditional open splenectomy for hepatocellular carcinoma (HCC) with hypersplenism. Between 2002 and 2013, 51 Chinese HCC patients with hypersplenism underwent either simultaneous laparoscopic splenectomy plus anticancer therapies (Lap-S&A) (n=25) or traditional open splenectomy plus anti-cancer therapies (TOS&A) (n=26). The outcomes were reviewed during and after the operation. Anti-cancer therapies for HCC included laparoscopic hepatectomy (LH) and laparoscopic microwave ablation (LMA)...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27464949/laparoscopic-rfa-with-splenectomy-for-hepatocellular-carcinoma
#6
Kunpeng Hu, Purun Lei, Zhicheng Yao, Chenhu Wang, Qingliang Wang, Shilei Xu, Zhiyong Xiong, He Huang, Ruiyun Xu, Meihai Deng, Bo Liu
BACKGROUND: The treatment of hepatocellular carcinoma (HCC) is complicated and challenging because of the frequent presence of cirrhosis. Therefore, we propose a novel surgical approach to minimize the invasiveness and risk in patients with HCC, hypersplenism, and esophagogastric varices. METHODS: This was a retrospective study carried out in 25 patients with HCC and hypersplenism and who underwent simultaneous laparoscopic-guided radio-frequency ablation and laparoscopic splenectomy with endoscopic variceal ligation...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26911860/recurrent-variceal-haemorrhage-managed-with-splenic-vein-stenting
#7
W El Kininy, L Kearney, N Hosam, P Broe, A Keeling
INTRODUCTION: Extrahepatic Portal Hypertension (EPH) is defined as extrahepatic hypertension of the portal venous system in the absence of liver cirrhosis. Isolated splenic vein stenosis/occlusion as one of the causes of extrahepatic portal hypertension is uncommon, comprising less than 5 % of all cases of portal hypertension. However, it is an increasingly recognised complication of both acute and chronic pancreatitis, and with the advent of more effective diagnostic methods, interventional radiological methods for its management are also becoming more effective...
February 25, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/26887878/-analysis-of-risk-factors-for-adverse-perinatal-outcomes-in-women-with-pancytopenia
#8
Xueyan Wang, Chao Zhang, Meiying Liang, Xiaohong Zhang, Jianliu Wang, Xia Zhang
OBJECTIVE: To explore the pregnancy outcomes of women with pancytopenia and the risk factors for the adverse perinatal outcomes. METHODS: A total of 106 pregnant women with pancytopenia were admitted to Peking University People's Hospital from Jan. 2005 to Sep. 2014. The clinical data and the pregnancy outcomes were reviewed retrospectively to investigate the risk factors for the adverse perinatal outcomes. RESULTS: (1 ) Eighty-four patients were found pancytopenia before pregnancy while 22 were found for the first time during pregnancy...
December 2015: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/26818539/postoperative-outcomes-after-open-splenectomy-versus-laparoscopic-splenectomy-in-cirrhotic-patients-a-meta-analysis
#9
Khaled Al-raimi, Shu-Sen Zheng
BACKGROUND: Laparoscopic splenectomy is considered the gold standard for resecting normal-to-moderately bigger spleens in benign conditions, and in addition could be tried for patients with malignant splenic disorders. However, the safety of laparoscopic splenectomy in patients with hypersplenism is not well-known. This study aimed to investigate the efficacy and safety of laparoscopic splenectomy for patients with hypersplenism secondary to liver cirrhosis by comparing with the open splenectomy...
February 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/26588331/gaucher-disease-clinical-biological-and-therapeutic-aspects
#10
REVIEW
Azza Dandana, Souhaira Ben Khelifa, Hinda Chahed, Abdelhédi Miled, Salima Ferchichi
We present a brief review of Gaucher disease (GD), the most common lysosomal storage disease. GD is a rare autosomal recessive disorder characterized by the defective function of the catabolic enzyme β-glucocerebrosidase (GBA), leading to an accumulation of its substrate, glucocerebroside. Clinical signs and symptoms include neurological dysfunctions, bone infarcts and malformations, hepatosplenomegaly and hypersplenism leading to anemia, neutropenia and thrombocytopenia. Enzyme replacement therapy with recombinant GBA is the mainstay of treatment for GD, which became the first successfully managed lipid storage disease...
2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26397320/an-overview-of-splenic-embolization
#11
REVIEW
Chaitanya Ahuja, Khashayar Farsad, Meghna Chadha
OBJECTIVE: The purpose of this article is to define the role of splenic embolization in trauma patients and in patients presenting for treatment of thrombocytopenia and portal hypertension. This article reviews the indications, technical considerations, outcomes, and complications of splenic artery embolization. CONCLUSION: Transcatheter splenic artery embolization has a major role in the management of traumatic splenic injuries and as an adjunctive procedure in the treatment of thrombocytopenia and portal hypertension...
October 2015: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/26205377/long-term-efficacy-of-subtotal-splenectomy-due-to-portal-hypertension-in-cirrhotic-patients
#12
Haibo Chu, Wei Han, Lei Wang, Yongbo Xu, Fengguo Jian, Weihua Zhang, Tao Wang, Jianhua Zhao
BACKGROUND: Portal hypertension (PHT) requires invasive measures to prevent rupture and bleeding of esophagogastric varices; however, the long-term results of subtotal splenectomy plus fixation of the retrosternal omentum majus (SSFROM) have not been reported. Specifically, the advantages and disadvantages of surgery that preserves the spleen and the long-term hematologic effects have not been described. STUDY DESIGN: Our studies relating to SSFROM commenced in February 1999...
2015: BMC Surgery
https://www.readbyqxmd.com/read/26111208/multimodality-imaging-of-primary-extrahepatic-portal-vein-obstruction-ehpvo-what-every-radiologist-should-know
#13
A Arora, S K Sarin
Portal vein thrombosis (PVT) is a frequent complication of liver cirrhosis, but it can also occur as a primary vascular disorder amid absent liver disease. Extrahepatic portal vein obstruction (EHPVO) refers to the obstruction of the extrahepatic portal vein with or without involvement of the intrahepatic portal vein branches, splenic and/or superior mesenteric vein. It is a distinct disorder that excludes PVT occurring in concurrence with liver cirrhosis or hepatocellular carcinoma. The term "EHPVO" implies chronicity and is principally reserved for a long-standing condition characterized by cavernous transformation of the portal vein...
August 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/26070848/laparoscopic-splenectomy-for-patients-with-liver-cirrhosis-improvement-of-liver-function-in-patients-with-child-pugh-class-b
#14
Naoki Yamamoto, Keiichi Okano, Minoru Oshima, Shitaro Akamoto, Masao Fujiwara, Joji Tani, Hisaaki Miyoshi, Hirohito Yoneyama, Tsutomu Masaki, Yasuyuki Suzuki
BACKGROUND: We aimed to assess the short-term outcomes of laparoscopic splenectomy (LS) and liver function at 1 year after splenectomy in the patients with liver cirrhosis. METHODS: Forty-five patients with liver cirrhosis and hypersplenism underwent LS. We reviewed electronic medical records regarding the liver functional reserve, the etiology of liver cirrhosis, and the presence of hepatocellular carcinoma and esophago-gastric varices. Prospectively collected data of perioperative variables, postoperative complications, and long-term liver function were analyzed...
December 2015: Surgery
https://www.readbyqxmd.com/read/26023944/multi-modality-imaging-of-primary-extra-hepatic-portal-vein-obstruction-ehpvo-what-every-radiologist-should-know
#15
Ankur Arora, Shiv Kumar Sarin
Portal vein thrombosis (PVT) is a frequent complication of liver cirrhosis but it can also occur as a primary vascular disorder amid absent liver disease. Extra-hepatic portal venous obstruction (EHPVO) refers to the obstruction of the extra-hepatic portal vein with or without involvement of the intra-hepatic portal vein branches, splenic and/or superior mesenteric vein. It is a distinct disorder that excludes PVT occurring in concurrence with liver cirrhosis or hepatocellular carcinoma. The term 'EHPVO' implies chronicity and is principally reserved for a long-standing condition characterized by cavernous transformation of the portal vein...
May 29, 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/25910248/successful-splenectomy-for-hypersplenism-in-wilson-s-disease-a-single-center-experience-from-china
#16
Liang-Yong Li, Wen-Ming Yang, Huai-Zhen Chen, Yun-Hu Wu, Xiang Fang, Jing Zhang, Zhen Wang, Yong-Sheng Han, Yu Wang
Splenomegaly and pancytopenia are common in Wilson's disease (WD) and splenectomy is one of the conventional treatments for splenomegaly and the associated pancytopenia. However, splenectomy remained controversial for hypersplenism in WD as it was reported that splenectomy leaded to serious emotional and neurological deterioration in WD patients with hypersplenism. In the current study, we present our experiences in 70 WD patients with hypersplenism who had undergone splenectomy, outlining the safety and efficacy of splenectomy in WD...
2015: PloS One
https://www.readbyqxmd.com/read/25738479/solitary-perihepatic-splenosis-mimicking-liver-lesion-a-case-report-and-literature-review
#17
Chao Wu, Binhao Zhang, Lin Chen, Bixiang Zhang, Xiaoping Chen
Hepatic splenosis, one type of manifestation of ectopic spleen tissue, is rarely reported. It cannot be distinguished from hepatic malignancies because of lack of significant radiological features. By means of this case report and 31 literature reviews, potential treatment modalities concerning clinical diagnostics, patient's management could be discussed.The report presents the case of a 33-year-old man with a liver lesion. Finally, after a mini-incision laparotomy, the lesion was resected and the diagnosis confirmed it as hepatic splenosis...
March 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25513097/synchronous-splenectomy-and-hepatectomy-in-patients-with-hepatocellular-carcinoma-hypersplenism-and-liver-cirrhosis
#18
Rui Shi, Ya-Min Zhang, Zhi-Jun Zhu, Yong-Lin Deng, Cheng Pan, Hong Zheng, Zhong-Yang Shen
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) mainly arises from underlying liver disease. Complicated liver cirrhosis and secondary hypersplenism are the most risk factors preventing surgical treatment of patients with HCC. The present study aimed at investigating the safety and long term outcome of patients with HCC and liver cirrhosis undergoing synchronous hepatectomy and splenectomy. METHODOLOGY: The clinical data of 306 cases of patients with HCC and liver cirrhosis undergoing curative hepatectomy were reviewed...
July 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25436312/synchronous-splenectomy-and-hepatectomy-in-patients-with-hepatocellular-carcinoma-hypersplenism-and-liver-cirrhosis
#19
Rui Shi, Ya-Min Zhang, Zhi-Jun Zhu, Yong-Lin Deng, Cheng Pan, Hong Zheng, Zhong-Yang Shen
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) mainly arises from underlying liver disease. Complicated liver cirrhosis and secondary hypersplenism are the most risk factors preventing surgical treatment of patients with HCC. The present study aimed at investigating the safety and long term outcome of patients with HCC and liver cirrhosis undergoing synchronous hepatectomy and splenectomy. METHODOLOGY: The clinical data of 306 cases of patients with HCC and liver cirrhosis undergoing curative hepatectomy were reviewed...
July 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25232555/splenic-lymphoma-with-massive-splenomegaly-case-report-with-review-of-literature
#20
Sachin B Ingle, Chitra R Hinge Ingle
As per strict criteria of Das Gupta et al, primary splenic lymphoma is very rare. Herein, we are reporting an unusual case of primary large cell splenic lymphoma of B lineage in a middle aged female presenting with massive splenomegaly (3.8 kg) and hypersplenism. After performing therapeutic splenectomy for hypersplenism, a precise diagnosis of diffuse large B cell lymphoma was made on histopathology and confirmed by immunohistochemistry. The patient responded well to standard (Cyclophosphamide, Hydroxydaunorubicin, Oncovin (vincristine), Prednisone or prednisolone) regimen last year and is now in full remission...
September 16, 2014: World Journal of Clinical Cases
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