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Head & neck oncology

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https://www.readbyqxmd.com/read/29138137/the-next-frontier-head-and-neck-cancer-immunoprevention
#1
J Silvio Gutkind, Jack D Bui
Restoring T cell-mediated antitumor immunity by targeting immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) results in immunomodulation and durable remissions. However, the overall response rate to these immunotherapies in HNSCC is only approximately 20%. This raises the possibility that immunologic intervention earlier in the HNSCC continuum, such as in oral premalignant lesions (OPL) could elicit an increased therapeutic response. New experimental studies suggest that immune therapies can be used for HNSCC prevention rather than therapy...
November 14, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29135033/primary-and-salvage-laser-surgery-of-341-glottic-cancers-comparison-of-treatment-outcomes-between-university-head-neck-tertiary-referral-center-and-local-head-neck-department
#2
Piotr Winiarski, Artur Lewandowski, Grażyna Greczka, Jacek Banaszewski, Hanna Klimza, Małgorzata Wierzbicka
OBJECTIVE: The main goal was to compare the clinical data of patients with T1 and T2 glottic cancer treated with CO2 transoral laser microlaryngoscopy (TLM) in the Tertiary Referral University Department of Otolaryngology, Head Neck Surgery, Poznan and the local Department of Otolaryngology, Oncology and Maxillofacial Surgery, Bydgoszcz. MATERIAL AND METHODS: Unified databases for the 7-year period January 2005-December 2011 were created to compare these two cohorts...
November 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29130149/is-lipidomic-the-answer-to-the-search-of-a-biomarker-for-organ-preservation-protocol-in-head-and-neck-squamous-cell-carcinoma
#3
Ana Carolina Laus, Ismael Dale Cotrim Guerreiro da Silva, Fernanda Bertuccez Cordeiro, Edson Guimarães Lo Turco, Luciano de Souza Viana, André Lopes Carvalho
In the last decade organ preservation protocols based on chemoradiotherapy (CRT) has been showing the possibility of preserving function without jeopardizing survival for locally advanced head and neck squamous cell carcinoma (HNSCC). Still, only a percentage of the patients will benefit from this approach and, to date, no biomarkers are known to correctly predict these patients. More recently, modern mass spectrometry method has been used to determine metabolic profiles, and lipidomics, in particular, emerged as a new field of study in oncology and other diseases...
November 13, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29128003/pet-mr-imaging-in-head-and-neck-cancer-current-applications-and-future-directions
#4
REVIEW
Samuel J Galgano, Ryan V Marshall, Erik H Middlebrooks, Jonathan E McConathy, Pradeep Bhambhvani
Clinical PET/MR imaging is being implemented at institutions worldwide as part of the standard-of-care imaging for select oncology patients. This article focuses on oncologic applications of PET/MR imaging in cancers of the head and neck. Although current published literature is relatively sparse, the potential benefits of a hybrid modality of PET/MR imaging are discussed along with several possible areas of research. With the increasing number of PET/MR imaging scanners in clinical use and ongoing research, the role of PET/MR imaging in the management of head and neck cancer is likely to become more evident in the near future...
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29127998/spectral-computed-tomography-technique-and-applications-for-head-and-neck-cancer
#5
REVIEW
Almudena Pérez-Lara, Reza Forghani
Spectral computed tomography (CT) or dual-energy CT (DECT) is an advanced form of CT with increasing applications in head and neck radiology. This article provides an overview of the DECT technique and reviews current applications for the evaluation of neck pathology, focusing on oncologic applications. Included are an overview of the basic underlying principles and approaches for DECT scan acquisition and material characterization; a discussion of various DECT reconstructions and a brief overview of practical issues pertaining to DECT implementation, including those related to workflow impact of DECT; and a discussion of various applications of DECT for the evaluation of the neck, especially in oncology...
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29126489/dental-treatment-planning-for-the-patient-with-oral-cancer
#6
REVIEW
Lauren E Levi, Rajesh V Lalla
Oral cancer therapy is associated with a multitude of head and neck sequelae that includes, but is not limited to, hyposalivation, increased risk for dental caries, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. Preparing a comprehensive treatment plan for patients undergoing cancer therapy is essential to help minimize their risks for developing these oral and dental complications. In addition, dentists must take into account a patient's ongoing oncologic therapy for those patients who present to the dentist while concurrently receiving cancer treatment...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29124365/change-in-reimbursement-and-costs-in-german-oncological-head-and-neck-surgery-over-the-last-decade-ablative-tongue-cancer-surgery-and-reconstruction-with-split-thickness-skin-graft-vs-microvascular-radial-forearm-flap
#7
Sebastian Hoefert, Oliver Lotter
OBJECTIVES: Defects after ablative tongue cancer surgery can be reconstructed by split-thickness skin grafts or free microvascular flaps. The different surgical options may influence costs, reimbursement, and therefore possible profits. Our goal was to analyze the development of these parameters for different procedures in head and neck reconstruction in Germany over the last decade. MATERIALS AND METHODS: After tumor resection and neck dissection of tongue cancer, three different scenarios were chosen to calculate costs, reimbursement, length of stay (LoS), and profits...
November 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29122486/trapezius-flaps-for-reconstruction-of-head-and-neck-defects-following-oncological-resection-a-systematic-review
#8
Conor M Sugrue, Grainne Rooney, Ryan M Sugrue
OBJECTIVE: Head and neck (H&N) reconstruction after cancer resection is challenging. Myocutaneous trapezius flaps provide an alternative reconstruction for patients not suitable for microvascular free tissue transfer. METHODS: A systematic review was performed on studies involving trapezius flaps for H&N reconstruction post oncological resection between the years 1985-2015. Data extracted included patient numbers and demographics, operative technique and complications...
October 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29121199/the-next-19-years-of-the-american-head-and-neck-society
#9
Jeffrey N Myers
Jeffrey N. Myers, MD, PhD, president of the American Head and Neck Society (AHNS) for 2016 to 2017, offered his perspectives on the AHNS's history, present-day activities, and future plans at this year's annual meeting of the society. The society was created from the 1998 merger of 2 societies, the Society for Head and Neck Surgeons (SHNS), founded in 1954, and the American Society for Head and Neck Surgery (ASHNS), founded in 1959, to become the largest organization in North America for the advancement of research and education in head and neck oncology...
November 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29116405/systematic-review-of-studies-reporting-positive-surgical-margins-after-bladder-neck-sparing-radical-prostatectomy
#10
REVIEW
Mariangela Bellangino, Clare Verrill, Tom Leslie, Richard W Bell, Freddie C Hamdy, Alastair D Lamb
PURPOSE OF REVIEW: Bladder neck preservation (BNP) during radical prostatectomy (RP) has been proposed as a method to improve early recovery of urinary continence after radical prostatectomy. However, there is concern over a possible increase in the risk of positive surgical margins and prostate cancer recurrence rate. A recent systematic review and meta-analysis reported improved early recovery and overall long-term urinary continence without compromising oncologic control. The aim of our study was to perform a critical review of the literature to assess the impact on bladder neck and base margins after bladder neck sparing radical prostatectomy...
November 7, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29114602/impact-on-quality-of-life-of-imrt-versus-3-d-conformal-radiation-therapy-in-head-and-neck-cancer-patients-a-case-control-study
#11
Edvard Abel, Ewa Silander, Jan Nyman, Mogens Bove, Leif Johansson, Thomas Björk-Eriksson, Eva Hammerlid
Objective: The purpose of this study was to prospectively and longitudinally compare the health-related quality of life (HRQOL) outcomes between head and neck (HN) cancer patients treated with parotid-sparing intensity modulated radiation therapy (IMRT) and patients treated with 3-dimensional conventional radiation therapy (3D-CRT). Methods and materials: Before and up to 12 months after treatment, HRQOL was recorded in patients with HN cancer who were referred to the Department of Oncology at Sahlgrenska University Hospital for curative IMRT...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29105781/prediction-of-mortality-and-morbidity-in-head-and-neck-cancer-patients-80-years-of-age-and-older-undergoing-surgery
#12
Heidi E L'Esperance, Dorina Kallogjeri, Shahnawaz Yousaf, Jay F Piccirillo, Jason T Rich
OBJECTIVES: To determine postoperative complications and mortality rates in octogenarian and older head and neck cancer patients undergoing ablative surgical resections and to identify factors associated with postoperative morbidity and mortality. METHODS: Retrospective cohort study investigating risk factors for 30-day serious complication risk and 90-day mortality risk for patients aged 80 years and older who underwent ablative head and neck oncologic surgical procedures at an academic tertiary care center between 2005 and 2015...
November 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29102390/comorbidities-clinical-features-and-prognostic-implications-of-cancer-patients-with-cerebrovascular-disease
#13
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, Héctor Spínola-Maroño, Gervith Reyes-Soto, Carlos Cantú-Brito
PURPOSE: The objective of this study was to identify and describe the comorbidities, clinical features, and prognostic implications of cancer patients with cerebrovascular disease. MATERIALS AND METHODS: All patients with cerebrovascular disease (CVD) seen in the neuro-oncology unit at a cancer referral center from April 2010 to November 2016 were included; demographic, oncologic diagnosis, risk factors, and prognostic considerations were presented as well. RESULTS: We report on 256 patients with CVD and cancer, of whom 66% were women...
October 25, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29100720/prognostic-factors-for-parotid-metastasis-of-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#14
C Bobin, P Ingrand, B Dréno, E Rio, O Malard, F Espitalier
BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) develops on the head in 80% of cases. Parotid metastasis (PM) is rare, but treatment, which associates surgery and radiation therapy, is heavy and prognosis poor. MATERIAL AND METHODS: All cases of parotidectomy for PM of CSCC of the head and neck between 2005 and 2015 were studied retrospectively. Epidemiologic, oncologic and therapeutic data were analyzed. Overall and specific survival were calculated following Kaplan-Meier...
October 31, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29098278/cranioplasty-using-a-mixture-of-biologic-and-nonbiologic-agents
#15
Demetri Arnaoutakis, Arash Bahrami, Jason E Cohn, Jesse E Smith
Importance: A surgeon faces challenges with cranioplasty techniques to achieve a successful result with relatively few complications. Objective: To describe a unique technique for incorporating both biologic autologous bone and nonbiologic allograft materials for defect coverage in cranioplasty with favorable outcomes and low occurrence of complications. Design, Setting, and Participants: A retrospective medical records review of all 26 patients who underwent primary cranioplasty procedure with a modified technique between January 2011 and December 2015 at a high-volume head and neck oncologic reconstructive practice was conducted; data analysis was also performed during that period...
November 2, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29097782/disease-relevant-signalling-pathways-in-head-and-neck-cancer-taspase1-s-proteolytic-activity-fine-tunes-tfiia-function
#16
Alena Gribko, Angelina Hahlbrock, Sebastian Strieth, Sven Becker, Jan Hagemann, Max Deichelbohrer, Andreas Hildebrandt, Negusse Habtemichael, Désirée Wünsch
Head and neck cancer (HNC) is the seventh most common malignancy in the world and its prevailing form, the head and neck squamous cell carcinoma (HNSCC), is characterized as aggressive and invasive cancer type. The transcription factor II A (TFIIA), initially described as general regulator of RNA polymerase II-dependent transcription, is part of complex transcriptional networks also controlling mammalian head morphogenesis. Posttranslational cleavage of the TFIIA precursor by the oncologically relevant protease Taspase1 is crucial in this process...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092758/navigation-guided-resection-of-maxillary-tumours-the-accuracy-of%C3%A2-computer-assisted-surgery-in-terms-of-control-of-resection-margins%C3%A2-a-feasibility-study
#17
Achille Tarsitano, Francesco Ricotta, Gennaro Baldino, Giovanni Badiali, Angelo Pizzigallo, Valerio Ramieri, Piero Cascone, Claudio Marchetti
INTRODUCTION: Surgical treatment of maxillary tumours is often highly complex. The three-dimensional anatomy of the mid-face renders both correct intraoperative orientation and adequate oncological safety difficult to obtain. Recently, computer-assisted techniques and intraoperative navigation have been applied to oncological surgery treating head and neck cancer. However, only a few studies have explored whether preoperative virtual resection planning and intraoperative control of resection margins allow assessment of the surgical margins of the tumour...
September 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29090194/the-pros-and-cons-of-computer-aided-surgery-for-segmental-mandibular-reconstruction-after-oncological-surgery
#18
REVIEW
Hyun Ho Han, Hak Young Kim, Jun Yong Lee
Computer-aided surgery (CAS) started being used for head and neck reconstruction in the late 2000s. Its use represented a paradigm shift, changing the concept of head and neck reconstruction as well as mandible reconstruction. Reconstruction using CAS proceeds through 4 phases: planning, modeling, surgery, and evaluation. Thus, it can overcome a number of trial-and-error issues which may occur in the operative field and reduce surgical time. However, if it is used for oncologic surgery, it is difficult to evaluate tumor margins during tumor surgery, thereby restricting pre-surgical planning...
September 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/29089727/european-society-of-cardiology-and-european-society-for-medical-oncology
#19
Walter Alexander
Key European Society of Cardiology sessions focused on reducing inflammation, lowering cardiovascular risk and cholesterol, and controlling hypertension, while significant clinical trials of medications for ovarian, lung, gastric, and head-and-neck cancers were presented at the European Society for Medical Oncology congress.
November 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29089142/survival-in-patients-with-parotid-gland-carcinoma-results-of-a-multi-center-study
#20
Keigo Honda, Shinzo Tanaka, Shogo Shinohara, Ryo Asato, Hisanobu Tamaki, Toshiki Maetani, Ichiro Tateya, Morimasa Kitamura, Shinji Takebayashi, Kazuyuki Ichimaru, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Masanobu Mizuta, Koichiro Yamada, Koichi Omori
BACKGROUND: Parotid gland carcinoma is a rare malignancy, comprising only 1-4% of head and neck carcinomas; therefore, it is difficult for a single institution to perform meaningful analysis on its clinical characteristics. The aim of this study was to update the clinical knowledge of this rare disease by a multi-center approach. METHODS: The study was conducted by the Kyoto University Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group (Kyoto-HNOG)...
October 24, 2017: American Journal of Otolaryngology
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